CN116036053A - External gel preparation patch for neck, shoulder, waist and leg pain, and preparation method and application thereof - Google Patents
External gel preparation patch for neck, shoulder, waist and leg pain, and preparation method and application thereof Download PDFInfo
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- CN116036053A CN116036053A CN202310066638.4A CN202310066638A CN116036053A CN 116036053 A CN116036053 A CN 116036053A CN 202310066638 A CN202310066638 A CN 202310066638A CN 116036053 A CN116036053 A CN 116036053A
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses an external gel preparation patch for neck, shoulder, waist and leg pain, a manufacturing method and application thereof, which solves the technical problem that the external gel patch is easy to curl or fall off in the prior art, and comprises the following steps: a backing layer; a gel layer; wherein the gel layer comprises a cold gel and an oxide film gel; the backing layer comprises a main body area and a blank area, wherein the blank area is arranged at the edge of the main body area, the main body area comprises a convex area and a plane area, and the height of the convex area is larger than that of the plane area; the cold gel is arranged in the plane area and the bulge area, the oxide film gel is arranged in the bulge area, the back lining layer, the oxide film gel and the cold gel are sequentially stacked in the bulge area, and the contact surface of the oxide film gel and the cold gel is an arc surface.
Description
Technical Field
The invention relates to the technical field of medical application, in particular to an external gel preparation patch for neck, shoulder, waist and leg pain, a preparation method and application thereof.
Background
The gel products have good application performance with skin, and become the main choice of long-acting slow release of skin medicine. The gel products mainly have two forms, one is spray-coating type, has unstable performance and can be rapidly oxidized to form a film; the other is of gel type, has stable shape and is easy to be attached to the skin. The gel is used as a carrier to carry medicine components, and has the effects of relieving pain and treating.
The gel patch product mainly comprises a backing layer, cold gel and release paper. The backing layer is made of a nonwoven or other non-toxic, heat-fusible, adhesive material. The cold gel is prepared from novel high molecular hydrophilic gel and auxiliary materials, has the advantages of large drug loading and good slow release effect, plays a role in physical cooling through water absorption and swelling, and can reduce local body surface temperature.
However, in the use process of the gel patch product, the edge of the back lining layer is easy to adhere to other articles, so that the back lining layer is easy to tear off, and the gel patch is particularly applied to the gel patch outside the neck, waist and leg.
In many cases, users tend to use plaster on the body parts such as the neck, the waist and the legs, and the plaster is firmly adhered. However, the plaster has a small drug-loading quantity and only has a thin layer, so that the effects of large drug-loading quantity and long-acting slow release of the gel plaster are not achieved; secondly, the plaster is too firm to be stuck to the skin, skin allergy is easy to cause, the plaster is difficult to tear, and the tearing process often brings pain to a user.
Disclosure of Invention
In order to solve the above-mentioned prior art problems, the present invention provides an external gel preparation patch for neck, shoulder, waist and leg pain, comprising:
a backing layer;
a gel layer;
wherein the gel layer comprises a cold gel and an oxide film gel;
the backing layer comprises a main body area and a blank area, wherein the blank area is arranged at the edge of the main body area, the main body area comprises a convex area and a plane area, and the height of the convex area is larger than that of the plane area;
the cold gel is arranged in the plane area and the bulge area, the oxide film gel is arranged in the bulge area, the back lining layer, the oxide film gel and the cold gel are sequentially stacked in the bulge area, and the contact surface of the oxide film gel and the cold gel is an arc surface.
As some alternative embodiments of the present application, the oxide film gel comprises a polydimethyl siloxane and a polydimethyl siloxane cross-linked polymer.
As some optional embodiments of the present application, the components of the cryogel include a sizing agent that is a polyacrylic resin.
As some optional embodiments of the present application, the solvent includes one or more of glycerol, propylene glycol, and ethanol polyethylene glycol.
As some optional embodiments of the present application, further comprising: release paper;
the release paper is arranged on the condensation glue, and the size of the release paper is the same as that of the backing layer.
As some optional embodiments of the present application, the width of the blank area is 1-2mm.
In order to solve the above technical problems, the present application further provides a method for manufacturing an external gel patch for neck, shoulder, waist and leg pain according to any one of the embodiments, including:
paving a backing in a manufacturing mould, wherein the manufacturing mould comprises a first groove and a second groove, the second groove is positioned at the edge of the first groove, and the depth of the second groove is larger than that of the first groove;
injecting the oxide film gel into the second groove, and smearing the oxide film gel to form an arc surface;
injecting the cold gel into the manufacturing mould to fill the first groove;
covering release paper on the manufacturing mould so that the edge of the release paper is attached to the edge of the back lining;
demolding to obtain the external gel preparation patch for neck, shoulder, waist and leg pain.
As an optional embodiment of the present application, the first groove and the second groove are uniformly provided with a plurality of through holes, and the through holes are connected with a negative pressure device.
As an alternative embodiment of the present application, the depth of the first groove is 2mm-4mm, and the depth of the second groove is 3.5mm-6mm.
In order to solve the above technical problems, the present application further provides an application of the external gel patch for neck, shoulder, waist and leg pain according to any one of the embodiments, including:
and removing the release paper, attaching one side of a gel layer of the external gel preparation patch for neck, shoulder, waist and leg pain to the skin surface, and pressing the raised area of the back lining layer to enable the oxide film gel to extend to and extend out of the blank area so as to form an oxide film extension area on the skin surface.
In summary, the beneficial effects of the application are as follows:
the gel preparation patch for external use for neck, shoulder, waist and leg pain comprises a gel layer, wherein the gel layer comprises cold gel and oxide film gel; the cold gel can be used as a carrier to carry medicine components, plays roles in relieving pain and treating, and has the advantages of large medicine carrying amount and good slow release effect compared with the plaster in the prior art; through the arrangement of the oxide film gel, the oxide film gel is arranged in a convex area of a main body area of the back lining layer, the contact surface of the oxide film gel and the cold gel is an arc surface, when the external gel preparation for treating neck, shoulder, waist and leg pain is smooth and excessive, and is difficult to warp due to the fact that the contact surface is an arc surface, the oxide film gel can form tension on the back lining layer, so that the oxide film gel flows out and flows out from a blank area and forms an extension area; further, as the backing layer of the external gel preparation paste for neck, shoulder, waist and leg pain is provided with the raised area, when the edge of a product is raised, a user can naturally press the periphery of the product and smooth the product, the paste is attached to a plane, and the effect of self education of the user is achieved through the product.
Drawings
Fig. 1 is a schematic structural diagram of an external gel preparation patch for neck, shoulder, waist and leg pain provided by the invention;
fig. 2 is a schematic cross-sectional view of the external gel preparation patch for neck, shoulder, waist and leg pain provided by the invention;
FIG. 3 is a schematic diagram of a mold according to the present invention;
FIG. 4 is a schematic cross-sectional view of a mold according to the present invention
Fig. 5 is a schematic diagram of a manufacturing mold and an external gel preparation patch for neck, shoulder, waist and leg pain provided by the invention;
reference numerals:
1. a backing layer; 2. oxide film gel; 3. cold gel; 4. release paper; 11. a planar region; 12. a raised region; 13. blank area; 21. a first groove; 22. a second groove;
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1:
referring to fig. 1 to 2, in order to solve the above-mentioned problems of the prior art, the present invention provides an external gel patch for treating pain in neck, shoulder, waist and leg, which is characterized by comprising:
a backing layer 1;
a gel layer;
wherein the gel layer comprises a cold gel 3 and an oxide film gel 2;
the backing layer 1 comprises a main body area and a blank area 13 arranged at the edge of the main body area, wherein the main body area comprises a convex area 12 and a plane area 11, and the height of the convex area 12 is larger than that of the plane area 11;
the cold gel 3 is arranged in the plane area 11 and the raised area 12, the oxide film gel 2 is arranged in the raised area 12, the backing layer 1, the oxide film gel 2 and the cold gel 3 are sequentially stacked in the raised area 12, and the contact surface of the oxide film gel 2 and the cold gel 3 is an arc surface.
In one embodiment, the backing layer 1 is made of one or two of non-woven fabric, polyurethane and elastic non-woven fabric;
specifically, the gel preparation patch for external use for neck, shoulder, waist and leg pain comprises a gel layer, wherein the gel layer comprises a cold gel 3 and an oxide film gel 2; the cold gel 3 can be used as a carrier to carry medicine components to play roles in relieving pain and treating, and compared with the plaster in the prior art, the cold gel 3 has the advantages of large medicine carrying amount and good slow release effect, and the medicine carrying amount of the cold gel 3 is far greater than that of the plaster; through the arrangement of the oxide film gel 2, the oxide film gel 2 is arranged in the convex area 12 of the main body area of the backing layer 1, the contact surface between the oxide film gel 2 and the cold gel 3 is an arc surface, when the external gel preparation for treating neck, shoulder, waist and leg pain is smooth and excessive by pressing and flattening the convex area 12 on the backing layer 1, the oxide film gel 2 can form inward extrusion force on the cold gel 3, and because the contact surface is an arc surface, the oxide film gel 2 can form tension on the backing layer 1, so that the oxide film gel 2 flows out and flows out through a blank area to form an extension area, and the external gel preparation for treating neck, shoulder, waist and leg pain is not easy to warp; further, as the backing layer 1 of the external gel preparation patch for neck, shoulder, waist and leg pain is provided with the raised area 12, when the edge of a product is raised, a user can naturally press the periphery of the product and smooth the product, the effect of attaching the product to a plane is achieved, and the self-education effect of the user is achieved through the product.
In an embodiment, the shape of the side of the oxide film gel contacting the backing layer is spoon-shaped, that is, the curvature of the shape of the side of the oxide film gel contacting the backing layer gradually increases in a first direction, and the first direction is a direction from a blank area to a plane area.
As some alternative embodiments of the present application, the components of the oxide film gel 2 include polydimethylsiloxane and polydimethylsiloxane cross-linked polymer.
In particular, when the external gel preparation for neck, shoulder, waist and leg pain is applied to the parts of human body such as neck, waist and leg, and the like, the parts are often covered by clothes, repeated friction is easily generated between the parts and the clothes, the edges of the gel patch are easily rolled up, and the gel patch is further displaced and falls off, so that in order to avoid the situation, in the embodiment, the components of the oxide film gel 2 comprise polydimethylsiloxane and polydimethylsiloxane crosslinked polymer;
the polydimethyl polysiloxane is colorless and odorless transparent liquid, has low surface tension, high surface activity and good film forming property, does not contain residual catalyst and decomposition products thereof and metal ions, and has the characteristics of no toxicity, no smell and no smell, so that the polydimethyl polysiloxane is more outstanding, has no irritation to human bodies and does not cause anaphylactic reaction;
after the raised area 12 of the external gel preparation patch backing layer 1 for neck, shoulder, waist and leg pain is pressed and smoothed, the oxide film gel 2 can form tension on the backing layer 1, so that the oxide film gel 2 flows out and flows out through a blank area to form an extension area, and the polydimethyl polysiloxane in the extension area can react with oxygen quickly, so that an oxide film is formed in the extension area, the edge of the external gel preparation patch for neck, shoulder, waist and leg pain and the oxide film are smoothly transited, the edge of the gel patch is not easy to roll up, and the gel patch is shifted and falls off;
furthermore, the surface of the polydimethyl polysiloxane in the air presents low surface energy, and the main reason is that the silica single chain is very flexible, under the condition of contacting air, methyl connected with silicon atoms can turn over to the surface, so that the surface presents hydrophobicity, an oxide film formed in an extension area has waterproof capability, and the gel is not easy to fall off when meeting water.
As some optional embodiments of the present application, the component of the cryogel 3 includes a gelling agent, which is a polyacrylic resin.
Specifically, the polyacrylic resin is also called as carbopol resin, the carbopol resin can form aqueous gel after being swelled in water and then being neutralized by alkali such as triethanol gum, and the drug loading rate of the cold gel 3 is far greater than that of the plaster, and the carbopol resin has the advantages of large drug loading rate and good slow release effect; in addition, by means of the heat absorption effect of the cold gel 3, the burning sensation on the skin surface can be rapidly absorbed, so that cool and comfortable sensation is brought to a patient, and the inflammation-induced red swelling and heat pain sensation is effectively relieved.
As some optional embodiments of the present application, the solvent comprises one or more of glycerol, propylene glycol, ethanol polyethylene glycol acid;
specifically, in this embodiment, in order to improve transparency of the colloid and increase freezing resistance of the product, when the patient has symptoms of closed soft tissue injury, such as contusion, muscle strain, joint ligament strain, scapulohumeral periarthritis, osteoarthritis and the like, the injury needs to be cold compress on the injured part within twenty-four hours, and due to the arrangement of the solvent, freezing resistance of the external gel preparation patch for neck, shoulder, waist and leg pain can be enhanced, so that the user can freeze the external gel preparation patch for neck, shoulder, waist and leg pain and then apply the external gel preparation patch on the affected part, and pain relieving and detumescence effects are enhanced.
As some optional embodiments of the present application, further comprising: a pharmaceutical composition;
specifically, in one embodiment, the pharmaceutical composition comprises: methyl salicylate;
the methyl salicylate has local stimulation effect, can promote local blood circulation, can produce skin vasodilation, skin redness and other stimulation reactions by external application or local smearing, and can reflectively influence skin, muscle, nerve and joints of corresponding parts, thereby playing roles in detumescence, anti-inflammation and analgesia, and also has antipruritic effect. Can be used for treating sprain, contusion, lumbago, myalgia, neuralgia, and antipruritic;
in another embodiment, the pharmaceutical composition further comprises: fentanyl;
fentanyl is an opioid receptor agonist and belongs to a powerful narcotic analgesic with pharmacological actions similar to morphine. Animal experiments show that the analgesic efficacy is about 80 times that of morphine. The analgesic effect is quick, but the duration is shorter, the effect is achieved 1 minute after intravenous injection, the peak is reached for 4 minutes, and the effect is maintained for 30 minutes;
in this embodiment, the pharmaceutical composition further comprises: a transdermal absorption enhancer;
a transdermal absorption enhancer capable of penetrating into the skin, and reducing the resistance of the drug passing through the skin without impairing the normal physiological function of the skin;
the transdermal absorption enhancer may use any compound known to increase skin permeability. By way of example and not limitation, the transdermal absorption enhancer includes fatty acids, fatty alcohols, fatty acid esters or ethers, aromatic organic acids, aromatic alcohols, aromatic organic acid esters or ethers having a carbon number of 6-20. In addition, lactate, acetate, monoterpene, sesquiterpene, glycerin fatty acid ester, sorbitan fatty acid ester, polysorbate, polyethylene glycol fatty acid ester, polyoxyethylene hardened castor oil, sucrose fatty acid ester, and the like can be cited. As some optional embodiments of the present application, further comprising: a release paper 4;
wherein the size of the release paper 4 is the same as the backing layer 1.
Specifically, in this embodiment, the external gel patch for neck, shoulder, waist and leg pain further includes release paper 4, where the release paper 4 is used as an anti-adhesive layer to cover the backing layer 1 and the gel layer, so as to avoid the gel patch from being contaminated before use.
As some optional embodiments of the present application, the width of the blank area 13 is 1-2mm, and the thickness of the oxide film gel 2 is 0.5-1.5mm.
In this embodiment, the width of the blank area 13 of the backing layer 1 is 1-2mm, the thickness of the oxide film gel 2 is 0.5-1.5mm, and the oxide film gel 2 and the cold gel 3 are not present on the blank area 13, which has the advantages that the backing layer and the release paper 4 can be easily separated, which is convenient for users to use and improves user experience; in addition, as the width of the blank area 13 is 1-2mm, the thickness of the oxidation gel is 0.5-1.5mm, after the raised area 12 of the backing layer 1 is smoothed in use, the oxide film gel 2 can cover the blank area 13 and can extend towards the blank area 13 to form an extension area, and the width of the extension area is 5-8mm, so that the sticking edge of the external gel preparation for neck, shoulder, waist and leg pain is smooth and excessive, and the sticking edge even falls off due to clothes friction is not easy to cause.
Example 2
In order to solve the above technical problems, the present application further provides a method for manufacturing an external gel patch for neck, shoulder, waist and leg pain according to any one of the embodiments, including:
s1, paving a backing in a manufacturing mould, wherein the manufacturing mould comprises a first groove 21 and a second groove 22, the second groove 22 is positioned at the edge of the first groove 21, and the depth of the first groove 21 is larger than that of the first groove 21;
specifically, firstly, paving a back lining in a manufacturing mould so that the back lining and the manufacturing mould are completely attached, wherein, as shown in fig. 3-5, the manufacturing mould comprises a first groove 21 and a second groove 22, the first groove 21 corresponds to a plane area 11 of the back lining layer of the external gel preparation for neck, shoulder, waist and leg pain, the second groove 22 corresponds to a convex area 12 of the back lining layer, and the depth of the second groove 22 is larger than that of the first groove 21 so as to form the convex area 12;
in one embodiment, the depth of the first groove 21 is 2mm-4mm, and the depth of the second groove 22 is 3.5mm-6mm.
S2, injecting the oxide film gel 2 into the second groove 22, and smearing the oxide film gel 2 to form an arc surface;
specifically, in the step, the oxidation film gel 2 is injected into the second groove 22, then the injected oxidation film gel 2 is smeared to form an arc surface, the arc surface is arranged to enable the oxidation film gel to form tension on the backing cloth when the oxidation film gel is extruded and smeared by a user, so that the oxidation film gel 2 covers the blank area 13 and extends outwards to form an extension area of 5-8mm, and the sticking edge of the external gel preparation for neck, shoulder, waist and leg pain is smooth and excessive, and the sticking edge even falls off due to clothes friction is not easy to cause;
s3, injecting the cold gel 3 into the manufacturing mold to fill the first groove 21;
s4, covering release paper 4 on the manufacturing mould, so that the edge of the release paper 4 is attached to the edge of the back lining;
then injecting the cold gel 3 into the manufacturing mould, filling the first groove 21, covering the manufacturing mould with release paper 4, flattening the cold gel 3 by plane extrusion of the release paper 4, attaching the edge of the release paper 4 to the edge of the back lining, covering the release paper 4, and then attaching an external gel preparation plaster for neck, shoulder, waist and leg pain and the manufacturing mould as shown in fig. 5;
s5, demolding to obtain the external gel preparation patch for neck, shoulder, waist and leg pain.
Finally, the external gel preparation paste for neck, shoulder, waist and leg pain is obtained through demolding, and as the backing layer 1 of the gel paste is provided with the raised area 12, the user instinctively can press the periphery of the product, and then instinctively smoothes, the effect of fitting into a plane is achieved, the periphery of the edge of the product is raised, and the effect of self-education of the user is also achieved through the product.
As an alternative embodiment of the present application, the first groove 21 and the second groove 22 are uniformly provided with a plurality of through holes, and the through holes are connected with a negative pressure device.
Specifically, since the manufacturing die includes the first groove 21 and the second groove 22, after the backing is laid, it is difficult to ensure that the backing is completely attached to the manufacturing die in the whole manufacturing process, so in this embodiment, the first groove 21 and the second groove 22 are uniformly provided with a plurality of through holes, and the through holes are connected with a negative pressure device so as to provide negative pressure to the backing through the through holes, so that the backing is adsorbed on the manufacturing die.
Example 3
The application also provides an application of the external gel preparation patch for neck, shoulder, waist and leg pain, which is characterized by comprising the following steps:
and removing the release paper, attaching one side of a gel layer of the external gel preparation patch for neck, shoulder, waist and leg pain to the skin surface, and pressing the raised area of the back lining layer to enable the oxide film gel to extend to and extend out of the blank area so as to form an oxide film extension area on the skin surface.
Specifically, when the external gel preparation is used, the raised area on the backing layer is pressed and smoothed, the oxidized film gel can form an inward extrusion force on the cold gel, and as the contact surface is an arc surface, the oxidized film gel can form tension on the backing layer, so that the oxidized film gel flows out and flows out from the blank area to form an extension area, the external gel preparation for neck, shoulder, waist and leg pain is smooth and excessive in sticking edge and difficult to warp edge; further, as the backing layer of the external gel preparation paste for neck, shoulder, waist and leg pain is provided with the raised area, when the edge of a product is raised, a user can naturally press the periphery of the product and smooth the product, the paste is attached to a plane, and the effect of self education of the user is achieved through the product.
In describing embodiments of the present invention, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "center", "top", "bottom", "inner", "outer", "inside", "outside", etc. indicate orientations or positional relationships based on the drawings are merely for the purpose of describing the present invention and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention. Wherein "inside" refers to an interior or enclosed area or space. "peripheral" refers to the area surrounding a particular component or region.
In the description of embodiments of the present invention, the terms "first," "second," "third," "fourth" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first", "a second", "a third" and a fourth "may explicitly or implicitly include one or more such feature. In the description of the present invention, unless otherwise indicated, the meaning of "a plurality" is two or more.
In describing embodiments of the present invention, it should be noted that the terms "mounted," "connected," and "assembled" are to be construed broadly, as they may be fixedly connected, detachably connected, or integrally connected, unless otherwise specifically indicated and defined; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
In the description of embodiments of the invention, a particular feature, structure, material, or characteristic may be combined in any suitable manner in one or more embodiments or examples.
In the description of the embodiments of the present invention, it is to be understood that "-" and "-" denote the same ranges of the two values, and the ranges include the endpoints. For example, "A-B" means a range greater than or equal to A and less than or equal to B. "A-B" means a range of greater than or equal to A and less than or equal to B.
In describing embodiments of the present invention, the term "and" is used herein to describe only one association relationship of association objects, meaning that three relationships may exist, e.g., a and B, may represent: a exists alone, A and B exist together, and B exists alone. In addition, the character "/" herein generally indicates that the front and rear associated objects are an "or" relationship.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. An external gel preparation patch for neck, shoulder, waist and leg pain, comprising:
a backing layer;
a gel layer;
wherein the gel layer comprises a cold gel and an oxide film gel;
the backing layer comprises a main body area and a blank area, wherein the blank area is arranged at the edge of the main body area, the main body area comprises a convex area and a plane area, and the height of the convex area is larger than that of the plane area;
the cold gel is arranged in the plane area and the bulge area, the oxide film gel is arranged in the bulge area, the back lining layer, the oxide film gel and the cold gel are sequentially stacked in the bulge area, and the contact surface of the oxide film gel and the cold gel is an arc surface.
2. The patch for external use according to claim 1, wherein the oxide film gel comprises a polydimethyl siloxane and a polydimethyl siloxane cross-linked polymer.
3. The external gel preparation patch for neck, shoulder, waist and leg pain according to claim 1, wherein the component of the cold gel comprises a gel forming agent, and the gel forming agent is polyacrylic resin.
4. The patch for external use according to claim 2, wherein the component of the cryogel further comprises a solvent, the solvent comprising one or more of glycerol, propylene glycol, and ethanol polyethylene glycol.
5. The external gel preparation patch for neck, shoulder, waist and leg pain according to claim 1, further comprising: release paper;
the release paper is arranged on the condensation glue, and the size of the release paper is the same as that of the backing layer.
6. The patch for external use according to claim 1, wherein the width of the blank area is 1-2mm and the thickness of the oxide film gel is 0.5-1.5mm.
7. A method of manufacturing the gel preparation patch for external use for neck, shoulder, waist and leg pain according to any one of claims 1 to 6, comprising:
paving a backing in a manufacturing mould, wherein the manufacturing mould comprises a first groove and a second groove, the second groove is positioned at the edge of the first groove, and the depth of the second groove is larger than that of the first groove;
injecting the oxide film gel into the second groove, and smearing the oxide film gel to form an arc surface;
injecting the cold gel into the manufacturing mould to fill the first groove;
covering release paper on the manufacturing mould so that the edge of the release paper is attached to the edge of the back lining;
demolding to obtain the external gel preparation patch for neck, shoulder, waist and leg pain.
8. The manufacturing method according to claim 7, wherein the first groove and the second groove are uniformly provided with a plurality of through holes, and the through holes are connected with a negative pressure device.
9. The method of claim 7, wherein the first groove has a depth of 2mm to 4mm and the second groove has a depth of 3.5mm to 6mm.
10. Use of the gel preparation patch for external use for neck, shoulder, waist and leg pain according to any one of claims 1 to 6, comprising:
and removing the release paper, attaching one side of a gel layer of the external gel preparation patch for neck, shoulder, waist and leg pain to the skin surface, and pressing the raised area of the back lining layer to enable the oxide film gel to extend to and extend out of the blank area so as to form an oxide film extension area on the skin surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310066638.4A CN116036053A (en) | 2023-02-06 | 2023-02-06 | External gel preparation patch for neck, shoulder, waist and leg pain, and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310066638.4A CN116036053A (en) | 2023-02-06 | 2023-02-06 | External gel preparation patch for neck, shoulder, waist and leg pain, and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116036053A true CN116036053A (en) | 2023-05-02 |
Family
ID=86113128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310066638.4A Withdrawn CN116036053A (en) | 2023-02-06 | 2023-02-06 | External gel preparation patch for neck, shoulder, waist and leg pain, and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116036053A (en) |
-
2023
- 2023-02-06 CN CN202310066638.4A patent/CN116036053A/en not_active Withdrawn
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Application publication date: 20230502 |