CN116019496A

CN116019496A - Nucleic acid sampling device and working method thereof

Info

Publication number: CN116019496A
Application number: CN202310061324.5A
Authority: CN
Inventors: 刘晓敏; 李龙基; 陈亮; 李静远
Original assignee: Fuzhou University
Current assignee: Fuzhou University
Priority date: 2023-01-19
Filing date: 2023-01-19
Publication date: 2023-04-28
Anticipated expiration: 2043-01-19
Also published as: CN116019496B

Abstract

The invention relates to a nucleic acid sampling device and a working method thereof, which are characterized in that: the nucleic acid sampling device comprises a machine body, and a swab feeding device, a sampling device, a test tube storage mechanism, a test tube loading and taking cover device and a sample processing device which are arranged on the machine body; the swab feeding device comprises a funnel for placing swabs and a rotary drum which is arranged at the lower outlet part of the funnel and is driven to rotate by a motor, wherein a fixing sleeve is sleeved on the periphery of the rotary drum, an upper groove and a lower groove are formed in the fixing sleeve, the upper groove is communicated with the lower outlet part of the funnel, at least one concave rotary groove is formed in the surface of the rotary drum, and a swab supporting seat is arranged below the lower groove; the nucleic acid sampling device and the working method thereof have convenience, safety and standardization, can save medical resources and can also improve the collection efficiency.

Description

Nucleic acid sampling device and working method thereof

Technical Field

The invention relates to a device for nucleic acid sampling and a working method thereof.

Background

The traditional nucleic acid sampling mode mainly adopts a manual mode to sample swabs, and the personnel interaction risks involved in the practical operation of the nucleic acid sampling mode are approximately that firstly, personnel gathering caused by queuing of a sampled person, secondly, interaction of identity recognition of the sampled person by medical staff, and finally, interaction of direct contact with the sampled medical staff after a mask is taken down, so that cross infection problems such as spray infection or aerosol infection are easy to occur; manual sampling therefore places medical personnel at a greater risk of infection than ordinary people.

The name of the invention is disclosed at present: device and method for automatically sampling nucleic acid based on artificial intelligence, publication number: patent document CN114224391a, although it can realize 1, parameter input; 2. preparing a sampling article; 3. preparing before sampling; 4. sampling operation; 5. cyclic operation of the manipulator mechanism; 6. a specimen transfer operation; 7. sterilizing and preparing articles in a sealed operation room; it does not disclose some mechanical configurations embodying the corresponding steps, such as how to achieve storage of the test tubes, opening and closing of the test tubes, etc.

Disclosure of Invention

In view of the above-mentioned shortcomings of the prior art, an object of the present invention is to provide a nucleic acid sampling device and a working method thereof, wherein the nucleic acid sampling device realizes a nucleic acid sampling work through a specific structure, so that medical resources can be saved, and sampling efficiency can be improved.

In order to achieve the above purpose, the invention adopts the following technical scheme:

the nucleic acid sampling device of the invention is characterized in that: comprises a machine body, a swab feeding device, a sampling device, a test tube storage mechanism, a test tube cover taking device and a sample processing device which are arranged on the machine body;

the swab feeding device comprises a funnel for placing swabs and a rotary drum which is arranged at the lower outlet part of the funnel and is driven to rotate by a motor, wherein a fixing sleeve is sleeved on the periphery of the rotary drum, an upper groove and a lower groove are formed in the fixing sleeve, the upper groove is communicated with the lower outlet part of the funnel, at least one concave rotary groove is formed in the surface of the rotary drum, and a swab supporting seat is arranged below the lower groove;

wherein the sampling device comprises a mechanical claw which can move along the axial direction of the machine body X, Y, Z and is used for clamping the swab;

the test tube storage mechanism comprises a rotatable friction rotary disc and a spiral notch type supporting disc arranged above the friction rotary disc, test tubes to be sampled are arranged in the spiral notch type supporting disc, and the friction rotary disc is supported at the bottom of each test tube so as to drive the test tubes to move along the spiral notch of the spiral notch type supporting disc;

the test tube loading and unloading cover device comprises a turbine clamping piece which can move along the Z-axis direction and is used for clamping a test tube cover to realize cover unloading, wherein the test tube clamping piece which can move along the X-axis direction is arranged below the turbine clamping piece, the test tube clamping piece clamps a test tube positioned in a spiral notch type supporting disc when moving to a first station in the X-axis direction, and the test tube clamping piece is right under the turbine clamping piece when moving to a second station in the X-axis direction so as to clamp the test tube cover by the turbine clamping piece;

the sample processing device comprises a total support piece, a swab rod guide groove and a swab head guide groove which are arranged on the total support piece, a cutting knife used for cutting a swab is arranged between the swab rod guide groove and the upper end of the swab head guide groove, the swab rod falls into a dustbin located below the swab rod along the swab rod guide groove after the swab is cut, and the swab head falls into a test tube located on the test tube clamping piece along the swab head guide groove after the swab is cut.

Further, the swab supporting seat comprises two arc-shaped blocks which are oppositely arranged, the two arc-shaped blocks are placed in the groove-shaped fixing frame, and the arc-shaped surface of each arc-shaped block faces to the lower groove of the fixing sleeve.

Further, a cam rotating shaft with a cam is arranged on the bottom surface of the outer side of the funnel, a slave belt wheel is arranged at the rear end of the cam rotating shaft, and the slave belt wheel is driven by a motor to rotate.

Further, the mechanical claw comprises a claw integral fixing seat and two driven gears which are arranged on the claw integral fixing seat and meshed with each other, the driven gears are arranged at the first ends of driven wheel connecting rods, the second ends of the driven wheel connecting rods are rotatably hinged at the first ends of clamping hand end pieces, the second ends of the clamping hand end pieces are used for clamping swabs, a positioning connecting rod is arranged between the integral fixing seat and the middle part of the clamping hand end pieces, a connecting rod is arranged between the center of each driven gear and the first ends of the clamping hand end pieces, and each driven gear is meshed with a driving gear positioned on the claw integral fixing seat; the claw integral fixing seat is provided with a bottom sliding seat capable of sliding on the X-direction guide rail.

Further, be equipped with the Z to back shaft that two sets of each two Z set up on the above-mentioned organism, be equipped with the Z to the Z that sets up to setting up between two Z to back shafts of every group to the lead screw, the nut seat that Z to lead screw and platform support carries out threaded connection to realize the platform support and remove at the Z, be equipped with Y respectively on two platform supports to the Y that sets up to the guide rail, be equipped with between two Y guide rails X is to the guide rail.

Further, the spiral groove type supporting disc is characterized in that a spiral groove is formed in a plate body, an elastic clamp is arranged at the groove opening of the spiral groove, the elastic clamp is a swing piece hinged at the groove opening in a rotating mode, and a torsion spring is arranged on a hinge shaft of the swing piece; another group of lower spiral notch type supporting plates and lower friction rotating plates for collecting sampled test tubes are arranged below the friction rotating plates; the bottom of friction rotary disk and lower friction rotary disk all is equipped with the band pulley, the band pulley side is equipped with the pivot that the Z set up, the pivot is equipped with the main shaft band pulley, the cover is equipped with synchronous belt on main shaft band pulley and the band pulley, the main shaft band pulley passes through another synchronous belt drive rotation that the driving motor drove.

Further, the test tube clamping piece comprises a clamping support and a fixing support, the fixing support is provided with a rotary table and a connecting rod with a first end eccentrically connected to the rotary table, a second end of the connecting rod is hinged to the clamping piece, the clamping piece is opposite to the clamping support so as to clamp a test tube, the fixing support is arranged on a motor support frame, the motor support frame is fixed on a sliding seat, the sliding seat is slidably connected to a conveying guide rail arranged in the X direction, and a chute for guiding the test tube after sampling into a lower spiral notch type supporting disc is arranged below the test tube clamping piece when the test tube clamping piece is located at a second station.

Further, the turbine clamping piece is connected to the lifting platform support, two ends of the lifting platform support are connected to lifting seats on two sides, the clamping support is arranged on the lower surface of the lifting platform support, the turbine clamping piece is composed of a clamping gear and a clamping arm, the center of the clamping gear is rotationally hinged to the lower side portion of the clamping support, and the two groups of clamping gears are meshed with worm pieces penetrating through the lifting platform support.

Further, the cutting knife is provided with a cutting knife B side and a cutting knife A side, the cutting knife A side is connected with a first end of a rocker, and a second end of the rocker is eccentrically connected to a rotating wheel driven by a motor; the swab head guide groove is provided with a resistance heater and a disinfectant nozzle so as to disinfect the swab head guide groove.

Further, a shell is arranged on the machine body, and a swab feeding cover, a sampling window, a code scanner, a magnetic card identifier, a test tube storage taking and placing port, a screen and a camera are arranged on the shell.

The working method of the nucleic acid sampling device of the invention,

firstly, a person to be sampled needs to provide a two-dimensional code or a magnetic card for identity authentication to identify before a code scanner or a magnetic card identifier of a nucleic acid sampling device, a camera can measure the body temperature of the person to be sampled during the period and feed back total information on a screen, and after the identity is checked, the screen prompts a user to move to a nucleic acid sampling window positioned right left for waiting for sampling; the test tube storage device rotates out a test tube through a rotary friction turntable, the test tube clamping piece moves to a first station to clamp the test tube and then moves out of the test tube storage mechanism, the test tube clamping piece moves to a position right below a turbine clamping piece of a second station test tube loading and unloading cover device, the turbine clamping piece of the test tube loading and unloading cover device is matched with the test tube clamping piece to enable a test tube cover to be separated from a test tube body, and a test tube with the test tube cover opened is moved to a position right below a swab head guide groove of the sample processing device to wait for a swab sample to enter; the sampling step is carried out, the related devices are a swab feeding device and a sampling device respectively, firstly, the sampling device moves a mechanical claw to the test tube feeding device, one provided swab on a swab supporting seat of the test tube feeding device is taken down, then the mechanical claw moves to a window position, and the swab is inserted into the oral cavity of a person to be tested to carry out wiping track similar to a human hand to obtain a sample; after the sampling is completed, the mechanical claw moves the swab between shearing cutters of the sample processing device to conduct cutting operation, and the sheared swab head containing the sample falls into the swab head guide groove through gravity so as to slide into the test tube; the residual part of the swab slides into the dustbin through the swab rod guide groove; the nozzle is responsible for the spraying of antiseptic solution, and resistance heater is then responsible for carrying out heating disinfection treatment to the guide slot to in time evaporate residual antiseptic solution.

The invention is suitable for sampling work in various scenes, effectively avoids participation of medical staff in a sampling link, reduces the risk of mutual infection between the medical staff and sampled staff, and has higher efficiency, safety and low cost compared with pure manual operation.

The invention integrates the mechanisms required by each link in the sampling highly, and effectively meets each function requirement in the sampling work.

Drawings

FIG. 1 is an isometric view of the overall structure of the present invention;

FIG. 2 is a front view (with the outer shell removed, etc.) of the internal structure of the present invention;

FIG. 3 is a perspective view of FIG. 2;

FIG. 4 is an isometric view of a tube storage mechanism;

FIG. 5 is an isometric view of the cuvette handler;

FIG. 6 is an isometric view of the tube loading and unloading cap device;

FIG. 7 is an isometric view of a swab feeding device;

FIG. 8 is an isometric view of a sampling device;

FIG. 9 is an enlarged view of portion B of FIG. 8 (i.e., an isometric view of the sampling device gripper);

FIG. 10 is an isometric view of a sample processing device;

FIG. 11 is a perspective view of the other view of FIG. 3;

FIG. 12 is a partial view of FIG. 6;

wherein fig. 1: 1. the device comprises a shell, a swab feeding cover, a sampling window, a code scanner, a magnetic card identifier, a test tube storage and taking-out and placing port, a screen, a camera and a screen, wherein the shell, the swab feeding cover, the sampling window, the code scanner, the magnetic card identifier, the test tube storage and taking-out and placing port, the screen and the camera are arranged in sequence;

fig. 2: a1, a swab feeding device, A2, a sampling device, A3, a test tube storage mechanism, A4, a test tube cover taking device, A5, a sample processing device, A6 and a dustbin;

fig. 4: 301. the device comprises an elastic clamp holder 302, a spiral notch type supporting disc 303, a supporting disc bracket 304, a friction rotating disc 305, a rotating disc base 306, a storage mechanism fixing frame 307, a rotating disc rotating shaft 308, a rotating disc bracket 309, a belt wheel 310, a main shaft belt wheel 311, a rotating shaft bracket 312, a transmission motor 313, a motor main belt wheel 314, a storage mechanism shell 315, a rotating shaft 316 and a pipe transmission belt wheel; 317. a lower spiral slot support disc, 318, a lower friction rotating disc;

fig. 5: 401. the device comprises a motor fixing seat, 402, a transportation guide rail, 403, a clamping support, 404, a clamping piece, 405, a fixed support, 406, a connecting rod, 407, a turntable, 408, a motor support frame, 409, a sliding seat, 410 and a transmission belt wheel support;

fig. 6: 501. lifting guide rails, 502, z-direction brackets, 503, fixing bolts, 504, lifting seats, 505, lifting platform brackets, 506, rotating shaft brackets, 507, transmission main shafts, 508, sliding grooves, 509, guide grooves, 510, code scanner brackets, 511, worm pieces, 512, turbine clamping pieces, 513, clamping brackets, 514, cylindrical motors, 515 and rotating shaft seats; 516. clamping gears 517, clamping arms;

fig. 7: 601. funnel, 602, rotary groove, 603, cam rotary shaft, 604, cam, 605, slave pulley, 606, fixing frame, 607, spring, 608, swab supporting seat;

fig. 8: 701. a z-direction support shaft 702, a nut seat 703, a fixed nut seat 704, a motor fixing seat 705, an x-direction guide rail, 706, a main belt pulley 707, a y-direction main shaft 708, a support piece 709, a platform bracket 710, an x-direction motor fixing seat 711, a support fixing seat 712, a z-direction screw rod 713, a bottom motor fixing frame 714, a y-direction guide rail 715, a belt pulley bracket 716 and a belt pulley shaft;

fig. 9: 720. clamping end piece 721, positioning connecting rod 722, connecting rod 723, driving gear 724, claw integral fixing seat 725, bottom sliding seat 726, sliding support 727, support 728, driven wheel connecting rod 729 and camera; 730. a driven gear;

fig. 10: 801. the spray head fixing seat, 802, the spray nozzle, 803, the spray head support, 804, the total support, 805, the swab head guide groove, 806, the resistance heater, 807, the swab rod guide groove, 808, the shearing knife B side, 809, the shearing knife A side, 810, the rocker, 811, the rotating wheel, 812, the fixed guide, 813 and the upper support.

Detailed Description

The invention will be further described with reference to the accompanying drawings and examples.

It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the present application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

The nucleic acid sampling device comprises a machine body, and a swab feeding device A1, a sampling device A2, a test tube storage mechanism A3, a test tube cover loading device A4 and a sample processing device A5 which are arranged on the machine body.

The swab feeding device A1 comprises a funnel 601 for placing swabs and a rotary drum 609 which is arranged at the lower outlet part of the funnel and is driven by a motor to rotate, a fixed sleeve 610 is sleeved on the periphery of the rotary drum, an upper groove 611 and a lower groove 612 are arranged on the fixed sleeve, the upper groove is communicated with the lower outlet part of the funnel, at least one concave rotary groove 602, preferably 2-6 rotary grooves, are arranged on the surface of the rotary drum, and a swab supporting seat 608 is arranged below the lower groove; the swab supporting seat comprises two arc-shaped blocks which are oppositely arranged, the two arc-shaped blocks are placed in the groove-shaped fixing frame 606, the arc-shaped surfaces of the arc-shaped blocks face the lower groove of the fixing sleeve, the rotating drum 609 is driven by a motor to rotate, when a certain rotating groove 602 is aligned with the upper groove 611, a swab positioned at the lowest position in the funnel 601 falls into the rotating groove 602 through the lower outlet part and the upper groove of the funnel, and the swab falls into the swab supporting seat 608 along with the continuous rotation of the rotating drum 609 when the swab falling into the rotating groove 602 is rotated to a position opposite to the lower groove, and then the swab waits for a mechanical claw to grasp.

In order to prevent the swab from being blocked in the funnel 601, a cam rotating shaft 603 with a cam 604 is arranged on the bottom surface of the outer side of the funnel, a slave belt pulley 605 is arranged at the rear end of the cam rotating shaft, the slave belt pulley is driven by a belt driven by a motor to rotate, and the motor drives the cam rotating shaft 603 and the cam 604 to regularly shake the funnel.

The shell of the invention is provided with a swab feeding cover 2 which is opposite to the upper opening of the funnel 601, and the swab can be added by removing the swab feeding cover 2.

Wherein the sampling device A2 comprises a mechanical claw B which can move along the axial direction of the machine body X, Y, Z and is used for clamping the swab;

the mechanical claw B comprises a claw integral fixing seat 724 and two driven gears 730 which are arranged on the claw integral fixing seat and meshed with each other, wherein the driven gears are arranged at the first ends of driven wheel connecting rods 728, the second ends of the driven wheel connecting rods are rotatably hinged at the first ends of clamping end pieces 720, the second ends of the clamping end pieces are used for clamping swabs, a positioning connecting rod 721 is arranged between the integral fixing seat 724 and the middle part of the clamping end pieces 720, a connecting rod 722 is arranged between the center of each driven gear and the first ends of the clamping end pieces, and the driven gears 730 are meshed with a driving gear 723 positioned on the claw integral fixing seat; the claw integral fixing seat 724 is provided with a bottom sliding seat 725 capable of sliding on the X-direction guide rail, when the driving gear 723 is driven by a motor (not shown in the drawing) to work, the driving gear is driven to rotate, and the driven gear connecting rod and the clamping end piece swing to clamp or release the swab at the end of the clamping end piece; the bottom slider 725 and the sliding support 726 thereon are pulled by synchronous pulleys to realize sliding on the X-direction guide rail, and synchronous belts for driving the bottom slider and the sliding support to move are omitted in the drawing, and the synchronous belts, the pulleys and the driving pulleys are all in the prior art and are not tired here.

The machine body is provided with two groups of two Z-direction supporting shafts 701, a Z-direction screw rod 712 arranged in the Z direction is arranged between the two Z-direction supporting shafts of each group, the Z-direction screw rod is in threaded connection with a nut seat of a platform bracket 709 to realize the movement of the platform bracket in the Z direction, Y-direction guide rails 714 arranged in the Y direction are respectively arranged on the two platform brackets, an X-direction guide rail 705 is arranged between the two Y-direction guide rails, and when the machine works, the Z-direction screw rod 712 is driven to rotate by a synchronous belt in the Z-axis direction, so that the platform bracket 709 is driven to lift in the Z-axis direction; in the Y-axis direction, both ends of the x-direction guide rail 705 are supported by the Y-direction guide rail 714 to slide, both ends of the x-direction guide rail 705 are respectively driven by a timing belt to move in the Y-direction, and the gripper moves along the x-direction guide rail 705 and also is driven to slide by the timing belt.

The test tube storage mechanism A3 comprises a rotatable friction rotary disc 304 and a spiral notch type supporting disc 302 arranged above the friction rotary disc, test tubes to be sampled are arranged in the spiral notch type supporting disc 302, the spiral notch type supporting disc 302 is provided with a spiral groove on a plate body, each test tube is inserted in the spiral groove, and the friction rotary disc 302 is supported at the bottom of each test tube to drive the test tube to move along the spiral notch of the spiral notch type supporting disc; another group of lower spiral notch type supporting discs 317 and lower friction rotating discs 318 for collecting sampled test tubes are arranged below the friction rotating discs; the bottom of friction rotary disk and lower friction rotary disk all is equipped with band pulley 309, the band pulley side is equipped with the pivot 315 of Z to setting, pivot 315 is equipped with main shaft band pulley 310, the cover is equipped with synchronous belt on main shaft band pulley 310 and the band pulley 309, main shaft band pulley passes through driving motor and drives direct rotation, or the main shaft band pulley 310 that is equipped with in the pivot, be equipped with motor main band pulley 313 on the motor output shaft, the cover is equipped with synchronous belt on motor main band pulley 313 and the main shaft band pulley 310 to realize driving pivot 315 and friction rotary disk rotation, promptly drive each test tube to march along the heliciform groove through frictional force between the two when friction rotary disk rotates.

The spiral grooves of the friction rotating disk 304 and the lower spiral groove type supporting disk 317 are different in rotation direction, and the spiral grooves of the friction rotating disk 304 are arranged counterclockwise from the outside to the inside, and the spiral grooves of the lower spiral groove type supporting disk 317 are arranged clockwise from the outside to the inside, as viewed from the top.

In order to play a limiting effect on the output of the test tube, the notch position of the spiral groove is provided with the elastic clamp 301, the elastic clamp is a swing piece hinged to the notch position in a rotating way, a torsion spring is arranged on a hinge shaft of the swing piece, and the acting force of the torsion spring on the swing piece is larger than the friction force of the friction rotating disk on the bottom of the test tube, so that when the swing piece is blocked, the friction rotating disk generates relative motion on the bottom of the test tube.

Wherein test tube dress is got and is covered device A4 is including being used for pressing from both sides tight test tube lid in order to realize getting the turbine clamping piece 512 of lid that can follow Z axial direction removal, the below of turbine clamping piece is equipped with the test tube clamping piece 404 that can follow X axial direction and remove, the test tube clamping piece presss from both sides when moving to first station in X axial direction and gets the test tube that is located spiral slot type supporting disk, the test tube clamping piece is just under the turbine clamping piece when moving to the second station in X axial direction to let turbine clamping piece clamp get test tube lid.

Specifically, the above-mentioned test tube clamping member 404 includes clamping support 403 and fixed bolster 405, be equipped with carousel 407 and first end eccentric connection connecting rod 406 on the carousel on the fixed bolster 405, the second end of connecting rod is articulated each other with a clamping member 404, and the clamping member is relative with clamping support to realize the centre gripping to the test tube, the fixed bolster 405 is established on motor support frame 408, motor support frame 408 is fixed on sliding seat 409, sliding seat sliding connection is on the transportation guide rail 402 that X set up, when test tube clamping member was located the second station, the below of test tube clamping member was equipped with the spout 508 that will sample the test tube and guide into lower spiral notch formula supporting disk 317.

Further, the turbine clamping member 512 is connected to the lifting platform support 505, two ends of the lifting platform support 505 are connected to the lifting seats 504 on two sides, a grip bracket 513 is arranged on the lower surface of the lifting platform support, the turbine clamping member is composed of a clamping gear 516 and a clamping arm 517, the center of the clamping gear is rotatably hinged to the lower side portion of the grip bracket 513, two groups of clamping gears are meshed with a worm member 511 penetrating through the lifting platform support, the worm member 511 is driven to rotate by a cylindrical motor 514, so that the clamping gear 516 and the clamping arm 517 are driven to swing, clamping and loosening of a test tube cover are achieved, a through shaft connected with the cylindrical motor 514 is arranged on the lifting platform support, the through shaft is driven to rotate by a motor, so that the test tube cover is screwed out or screwed into the test tube (when the lower portion of the test tube is clamped by the test tube clamping member 404, when the test tube cover is not clamped by the turbine clamping member 512, the whole rotation of the test tube is achieved, and at this time, information on the test tube can be scanned by a scanner of the device, so that a tested person can correspond to information.

The sample processing device A5 comprises a total support 804, a swab rod guide groove 807 and a swab head guide groove 805 which are arranged on the total support 804, a cutting knife for cutting a swab is arranged between the swab rod guide groove 807 and the upper end of the swab head guide groove 805, the swab rod falls into a dustbin positioned below the swab rod along the swab rod guide groove after the swab is cut, and the swab head falls into a test tube positioned on the test tube clamping piece along the swab head guide groove after the swab is cut.

Specifically, the cutting knife is provided with a cutting knife B side and a cutting knife A side, the cutting knife A side is connected with a first end of a rocker 810, a second end of the rocker is eccentrically connected to a rotating wheel 811 driven by a motor, and the rotating wheel 811 is pressed towards or away from the cutting knife B side when driven by the motor, so that the cutting of a swab is realized; the swab head guide 807 is provided with a resistance heater 806 and a nozzle 802 for disinfectant, and the swab head guide can be disinfected through the resistance heater 806 and the nozzle 802 for disinfectant so as to avoid cross infection; the machine body is provided with a shell 1, and the shell is provided with a swab feeding cover 2, a sampling window 3, a code scanner 4, a magnetic card identifier 5, a test tube storage and taking opening 6, a screen 7 and a camera 8, wherein the opening of a person to be detected is aligned with the sampling window 3, so that a swab clamped by a mechanical claw extends out of the sampling window 3 and into the oral cavity of the person to be detected for sampling; the code scanner 4 and the magnetic card identifier 5 are used for scanning identity documents and the like of a person to be detected, the test tube storage taking and placing port 6 is opposite to the spiral notch type supporting disc, the test tube is convenient to supplement, the camera 8 is used for shooting the person to be detected, and the screen 7 is used for human-computer interaction.

The above-mentioned components (such as the slide base of fig. 5, the gripper of fig. 8) are moved along the rail of X, Y or Z-axis, and they can be driven by a linear motor, a screw-nut mechanism, or the like.

The working method of the nucleic acid sampling device of the invention,

The mechanism design of the scheme of the invention focuses on the utilization rate of space, optimizes the structure of each module as much as possible based on the functional target to be realized, thereby reducing the occupied space, comprehensively and comprehensively reducing the whole size of the machine, avoiding the redundant design of the mechanism in the module in the aspect of the integration level of the machine, tightly connecting the structure of each module in the machine and the functions thereof, and reducing the whole energy consumption while improving the compactness and the portability of the mechanism; in this application, carried out the function integration to identification registration module, adopted all integrated in the planar design of casing with camera, screen, two-dimensional code scanning and magnetic card recognition device, the purpose is the convenient operation of the user streamline dynamics of being convenient for. In the application, the scheme of pushing the test tube by the spiral notch type supporting disc of the test tube storage mechanism improves the convenience of test tube access, timely and efficiently provides test tubes for a machine and stores test tubes with samples, and in the application, the test tube transport module plays a role of connecting the test tube storage module, the test tube opening and closing module and the sample shearing module, so that the space utilization rate of each module inside the machine is improved under the condition of avoiding interference; for the opening and closing aspect of the test tube, the test tube opening and closing module of the machine adopts a gripper mechanism (turbine clamping piece) of a threaded screw mechanism, can provide enough torque and simultaneously prevent the gripper from loosening, and in the aspect of sampling, on the basis of ensuring the sampling precision and high-efficiency interaction of a sampled person, a three-dimensional movement mechanism driven by a motor is adopted, so that the cost is reduced and the space utilization rate is improved; in sample shearing after taking the sample, the present solution employs a crank-rocker mechanism that provides a reciprocating shearing motion to shear off the front end of the swab with the sample, allowing the sample to be taken into the test tube.

Advantages and uses of the product

The product can be suitable for sampling work under various scenes, effectively avoids participation of medical staff in a sampling link, reduces the risk of mutual infection between the medical staff and sampled staff, and has higher efficiency, safety and low cost compared with pure manual operation.

The functional device required by each link in the highly integrated sampling of the product effectively realizes each functional requirement in the sampling work, provides a comfortable and convenient way for the self-help nucleic acid sampling of the sampled person, avoids the aggregation of people and the germ transmission among medical staff, and is more safe and more worry-saving.

The automated storage and retrieval of the test tube is realized by the test tube storage mechanism adopted by the product, the internal space of the machine is saved, the test tube can be efficiently connected with each functional component, meanwhile, the storage of the test tube is separated from the outside, the test tube can be prevented from being attached to the external environment, especially germs, and the safety guarantee is provided for the follow-up test tube sampling detection. The test tube can be expanded to a certain extent in the existing quantity, and the size of the test tube can be correspondingly adapted at low cost.

This product has adopted rotatory sign indicating number integral type operation of sweeping to uncapping of test tube and sweeping sign indicating number registration processing, can discern the registration to the bar code of test tube when unscrewing to test tube cap, this smoothness of guaranteeing the flow has promoted the efficiency of sampling.

The swab feeding device can be used for rapidly feeding and clamping the swab, compared with the traditional manual tearing of the swab package and extraction of the swab, the feeding device effectively improves the feeding speed of the swab, abandons the independent package of the swab, and can reduce the purchase cost of the swab. The sealed inner cavity can also isolate the swab from the outside air, so that the safety and the sanitation of the swab are ensured.

The three-dimensional sampling tong device of lightweight has been adopted to this product, compares industry joint linkage formula manipulator, and the cost is reduced by a wide margin under the circumstances of guaranteeing the precision, and the control degree of difficulty also obtains certain decline simultaneously, is convenient for carry out the design and the control of sampling action, has realized the general suitability of lightweight nucleic acid automatic sampling device.

The product adopts a modularized design, and the whole device is simple and convenient, compact in structure, high in automation degree, convenient to operate, high in stability and working efficiency, and can be widely applied to public places such as hospitals, superproviders and the like.

The above-described embodiments are provided to further explain the objects, technical solutions, and advantageous effects of the present invention in detail. It should be understood that the foregoing is only illustrative of the present invention and is not intended to limit the scope of the present invention. It should be noted that any modifications, equivalent substitutions, improvements, etc. made by those skilled in the art without departing from the spirit and principles of the present invention are intended to be included in the scope of the present invention.

Claims

1. A nucleic acid sampling device, characterized in that: comprises a machine body, a swab feeding device, a sampling device, a test tube storage mechanism, a test tube cover taking device and a sample processing device which are arranged on the machine body;

2. The nucleic acid sampling device of claim 1, wherein: the swab supporting seat comprises two arc blocks which are oppositely arranged, the two arc blocks are placed in the groove type fixing frame, and the arc surface of each arc block faces to the lower groove of the fixing sleeve.

3. The nucleic acid sampling device of claim 2, wherein: the outer bottom surface of the funnel is provided with a cam rotating shaft with a cam, the rear end of the cam rotating shaft is provided with a slave belt wheel, and the slave belt wheel is driven by a motor to rotate.

4. The nucleic acid sampling device of claim 3, wherein: the mechanical claw comprises a claw integral fixing seat and two driven gears which are arranged on the claw integral fixing seat and meshed with each other, the driven gears are arranged at the first ends of driven wheel connecting rods, the second ends of the driven wheel connecting rods are rotatably hinged to the first ends of clamping hand end pieces, the second ends of the clamping hand end pieces are used for clamping swabs, a positioning connecting rod is arranged between the integral fixing seat and the middle part of the clamping hand end pieces, a connecting rod is arranged between the center of each driven gear and the first ends of the clamping hand end pieces, and each driven gear is meshed with a driving gear positioned on the claw integral fixing seat; the claw integral fixing seat is provided with a bottom sliding seat capable of sliding on the X-direction guide rail.

5. The nucleic acid sampling device of claim 4, wherein: the machine body is provided with two groups of Z-direction supporting shafts which are respectively arranged in the Z direction, a Z-direction screw rod which is arranged in the Z direction is arranged between the two Z-direction supporting shafts of each group, the Z-direction screw rod is in threaded connection with a nut seat of the platform support, so that the platform support can move in the Z direction, Y-direction guide rails which are respectively arranged in the Y direction are arranged on the two platform supports, and X-direction guide rails are arranged between the two Y-direction guide rails.

6. The nucleic acid sampling device of claim 5, wherein: the spiral groove type supporting disc is characterized in that a spiral groove is formed in a plate body, an elastic clamp is arranged at the groove opening of the spiral groove, the elastic clamp is a swing piece hinged at the groove opening in a rotating mode, and a torsion spring is arranged on a hinge shaft of the swing piece; another group of lower spiral notch type supporting plates and lower friction rotating plates for collecting sampled test tubes are arranged below the friction rotating plates; the bottom of friction rotary disk and lower friction rotary disk all is equipped with the band pulley, the band pulley side is equipped with the pivot that the Z set up, the pivot is equipped with the main shaft band pulley, the cover is equipped with synchronous belt on main shaft band pulley and the band pulley, the main shaft band pulley passes through another synchronous belt drive rotation that the driving motor drove.

7. The nucleic acid sampling device of claim 6, wherein: the test tube clamping piece comprises a clamping support and a fixing support, the fixing support is provided with a rotary table and a connecting rod with a first end eccentrically connected to the rotary table, the second end of the connecting rod is hinged to a clamping piece, the clamping piece is opposite to the clamping support so as to clamp a test tube, the fixing support is arranged on a motor support frame, the motor support frame is fixed on a sliding seat, the sliding seat is slidably connected to a transportation guide rail arranged in the X direction, and when the test tube clamping piece is located a second station, a chute for guiding the test tube after sampling into a lower spiral notch type supporting disc is arranged below the test tube clamping piece.

8. The nucleic acid sampling device of claim 7, wherein: the turbine clamping piece is connected to the lifting platform support, two ends of the lifting platform support are connected to lifting seats on two sides, a clamping hand support is arranged on the lower surface of the lifting platform support, the turbine clamping piece is composed of a clamping gear and a clamping arm, the center of the clamping gear is rotationally hinged to the lower side portion of the clamping hand support, and the two groups of clamping gears are meshed with worm pieces penetrating through the lifting platform support.

9. The nucleic acid sampling device of claim 8, wherein: the cutting knife is provided with a cutting knife B side and a cutting knife A side, the cutting knife A side is connected with a first end of a rocker, and a second end of the rocker is eccentrically connected to a rotating wheel driven by a motor; the swab head guide groove is provided with a resistance heater and a disinfectant nozzle so as to disinfect the swab head guide groove; the machine body is provided with a shell, and the shell is provided with a swab feeding cover, a sampling window, a code scanner, a magnetic card identifier, a test tube storage taking and placing port, a screen and a camera.

10. A method of operating a nucleic acid sampling device according to claim 9,