CN1160136C - Ultrasonic wave heat therapeutic apparatus and focus temp. pre-measuring method - Google Patents
Ultrasonic wave heat therapeutic apparatus and focus temp. pre-measuring method Download PDFInfo
- Publication number
- CN1160136C CN1160136C CNB011397160A CN01139716A CN1160136C CN 1160136 C CN1160136 C CN 1160136C CN B011397160 A CNB011397160 A CN B011397160A CN 01139716 A CN01139716 A CN 01139716A CN 1160136 C CN1160136 C CN 1160136C
- Authority
- CN
- China
- Prior art keywords
- temperature
- wave source
- focus
- focus temp
- temp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 27
- 230000001225 therapeutic effect Effects 0.000 title abstract description 11
- 239000000523 sample Substances 0.000 claims abstract description 5
- 238000000015 thermotherapy Methods 0.000 claims description 25
- 238000004364 calculation method Methods 0.000 claims description 14
- 238000009826 distribution Methods 0.000 claims description 12
- 206010020843 Hyperthermia Diseases 0.000 claims description 7
- 230000036031 hyperthermia Effects 0.000 claims description 7
- 238000005259 measurement Methods 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 230000008676 import Effects 0.000 claims description 3
- 230000006378 damage Effects 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 description 11
- 238000002604 ultrasonography Methods 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 4
- 238000006073 displacement reaction Methods 0.000 description 3
- 238000000053 physical method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010048038 Wound infection Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000004422 calculation algorithm Methods 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 230000003467 diminishing effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000007669 thermal treatment Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Surgical Instruments (AREA)
Abstract
The present invention relates to an ultrasonic wave heat therapeutic machine and a prediction method for focal temperature. The ultrasonic wave heat therapeutic machine comprises a high-energy focusing ultrasonic wave source, a probe of a B-scan machine, which is arranged in the wave source, a computer and a control stand, wherein the computer comprises an input unit for inputting treatment parameters, a focal temperature inquiry unit which is connected with the input unit and is used for inquiring a corrected temperature comparison table according to input parameters to obtain the focal temperature and an output unit for outputting the focal temperature. The heat therapeutic machine of the present invention can measure temperature for a focal point without loss, and thus, the prevent invention avoids the damage to a human body and ensures that the treatment parameters of every time can reach optimal therapeutic effect.
Description
Technical field
The present invention relates to the external ultrasound wave of a kind of patient of utilization (HIFU) wave source and send the medical treatment device that effect that high-energy concentration ultrasonic produces in focus is killed pathological tissues, particularly, relate to the Forecasting Methodology of ultrasonic hyperthermia machine and focus temp thereof.
Background technology
At present, the HIFU therapy equipment is one of focus of domestic and international medical research, and clinical practice has obtained good effect.Practical external HIFU heat therapy machine generally is made of following several sections:
A. high-energy concentration ultrasonic source and drive circuit---in order to produce high-energy concentration ultrasonic.
B. navigation system---be used to seek therapeutic goal and it is moved to ultrasonic transducer focus place.Comprise a medical video system (mostly being the B ultrasonic machine), a carrying patient's device (for example bed surface), and with the displacement system of this device with wave source catch cropping space relative displacement.
C. high-energy ultrasound conducting structure and transmitting medium processing system---because the ultrasound wave that HIFU is suitable for must import in patient's body by special transmitting medium (using the water of handling through the degassing) more, so must have in the place ahead of the high-energy concentration ultrasonic source surface of emission one hold the structure (as tank, water pocket etc.) of transmitting medium and add, the discharge transmitting medium reaches the device that medium is handled.
Use during the above-mentioned heat therapy machine, the direct method that obtain heat therapy machine focus place temperature is done physical measurement exactly, wherein is divided into again diminishing two kinds of thermometric and noninvasive temperature estimations:
It is fairly simple to diminish thermometric, wherein temperature sensor is directly inserted in the human body body, thereby the temperature at acquisition focus place owing to be direct measurement, can accurately obtain the temperature at focus place.But because this method need be inserted temperature sensor in the human body body, this not only can cause patient's misery, and can bring wound infection, so directly the physical measurement method is difficult to be applied in the actual therapeutic of heat therapy machine.
And noninvasive temperature estimation is exactly human body not to be caused physical injury, and directly obtains method of temperature in the human body, and the principle of noninvasive temperature estimation is a lot, as CT, ultrasound wave etc., but all is in theoretical research stage at present.
In fact, the parameter that the doctor is adopted when confirming to treat according to the actual therapeutic experience of oneself usually, the randomness of therefore treating the parameter selection is very big, can not guarantee that each treatment parameter can both reach best therapeutic effect.
This just need a kind ofly overcome the ultrasonic hyperthermia machine of above-mentioned defective of the prior art and the Forecasting Methodology of focus temp thereof, thereby directly instructs doctor's clinical treatment.
Summary of the invention
The object of the present invention is to provide a kind of can avoiding that the patient is used heat therapy machine and the focus temp Forecasting Methodology thereof that diminishes thermometric and can more accurately must obtain focus temp, wherein predict the temperature at focus place by computer Simulation calculation.
In order to realize above-mentioned purpose of the present invention, the invention provides a kind of ultrasonic hyperthermia machine, it comprises: the high-energy concentration ultrasonic source, be installed on the B ultrasonic machine probe of wave source inside, computer and control station, wherein: described computer comprises the input block that is used to import the treatment parameter, link to each other with input block and to be used for inquiring about revised temperature synopsis to obtain the focus temp query unit of focus temp according to input parameter, and the output unit that is used to export described focus temp, and wherein said focus temp query unit comprises: the Theoretical Calculation module, be used to calculate theoretical focal point temperature under the different condition to obtain the focus temp synopsis of heat therapy machine, and temperature synopsis correcting module, be used for temperature revised theory temperature synopsis according to actual measurement.
In addition, the present invention also provides a kind of heat therapy machine focus temp Forecasting Methodology, comprising following step: will treat parameter by input block and be input to the focus temp query unit; According to the condition of input, the revised focus temp synopsis that the inquiry of focus temp query unit is stored obtains focus temp; Described focus temp is exported by output unit, and the revised temperature synopsis in the wherein said focus temp query steps obtains like this: at first calculate the theoretical focal point temperature under the different condition, to obtain the theoretical focal point temperature synopsis of heat therapy machine; According to the temperature of actual measurement, revised theory temperature synopsis; And store described revised temperature synopsis.
Because the present invention inserts the patient's misery that causes in the human body body so the present invention has exempted with temperature sensor, and does not also have the wound infection problem without the temperature at direct physical measurement focus place.In addition, also overcome the random big problem of the treatment parameter selection that in the heat therapy machine of prior art, occurs.Because the principle of heat therapy machine is exactly that the high temperature that utilizes focus ultrasonic to produce comes the kill tumor cell, therefore, use this heat therapy machine and temp measuring method thereof in practice, the doctor can adjust the treatment parameter according to focus temp provided by the present invention, to guarantee that there is sufficiently high temperature at the focus place, has so just improved the actual therapeutic effect.
Description of drawings
Fig. 1 is the structure diagram of heat therapy machine of the present invention;
Fig. 2 is the main composition figure of the computer of heat therapy machine of the present invention;
Fig. 3 is the diagrammatic sketch that is used for the calculating of the disk sound intensity of the present invention;
Fig. 4 is the diagrammatic sketch that is used for wave source METHOD FOR SOUND POWER CALCULATION of the present invention;
Fig. 5 is the flow chart that the present invention is used to calculate focus temp;
Fig. 6 is that the present invention is used to calculate the sketch map of revising back temperature synopsis;
Fig. 7 is the sketch map of the Forecasting Methodology of heat therapy machine focus temp of the present invention.
The specific embodiment
Specifically describe a HIFU heat therapy machine example with reference to figure 1.Number in the figure 1 is the heat therapy machine control station; Label 2 is the computer on the control station; Label 3 is a B ultrasonic machine display; Label 12 is the therapeutic bed bed surface, is used to carry the patient; Label 4,5 is respectively and drives the mechanism of bed surface along horizontal longitudinal and transverse two directions displacement; Label 9 is the high-energy concentration ultrasonic source, and label 7 is for being installed on the B ultrasonic machine probe of wave source inside; Label 6,8 is respectively and drives Ultrasonic-B probe is made rotation, lifting moving in wave source mechanism; Label 10 holds the tank of transmitting medium for the wave source top; And label 11 is for driving the mechanism that wave source moves up and down.Content for prior art is not described in detail in this.To describe computer of the present invention in detail below.
The computer of heat therapy machine of the present invention has the forecast function of focus temp, and its main composition mainly comprises input block 21, focus temp query unit and output unit 22 as shown in Figure 2.Input block (as keyboard) is used for input treatment parameter.Focus temp query unit 23 links to each other with input block and is used for inquiring about revised temperature synopsis with the output focus temp according to input parameter, it links to each other with the temperature synopsis correcting module 25 that is used for according to the temperature revised theory temperature synopsis of actual measurement, obtains revised focus temp and it is stored in focus temp query unit 23 at correcting module 25 with the Theoretical Calculation module 24 and the actual measurement part 26 of the focus temp synopsis that obtains heat therapy machine by the theoretical focal point temperature that is used for calculating under the different condition that links to each other with input block.Output unit can be display or other known output device, is used for the focus temp that output (or demonstration) inquires by the focus temp query unit.
The concrete work process of Theoretical Calculation module is as described below:
At first by input block (as keyboard) input treatment parameter, described parameter can be the parameter that directly influences focus place temperature, for example: input electric power, emitter conversion efficiency, emission parameter, tissue characteristics, target skin distance, wave source characteristic.Wherein emission parameter comprises: launch time, intermittent time, single-point emitting times.The wave source characteristic comprises: initial angle that wafer radius, wave source distribute and end angle, disk number.Because what adopt in actual the use is a kind of wave source, so wave source parameter and emitter conversion efficiency are fixed.Carry out following algorithm then:
This algorithm mainly contains two parts and forms: the distribution of wave source sound field is calculated and the temperature field distributes calculates.
1. the wave source sound field distributes and calculates
Calculate focus temp, the sound field that at first must calculate wave source distributes.
Because actual wave source is made up of many sequins, so at first study single sequin at the sound intensity that the space produced.
The computational methods of the disk sound intensity
As shown in Figure 3, disk surfaces is divided into unlimited multi-facet unit.Each little bin can be regarded a point source as, is positioned at the utmost point and directly is ρ, and polar angle is the bin dS at φ place, and its source strength is dQ=UadS, and this bin in the acoustic pressure that point of observation P produces is:
U wherein
aBe the Oscillation Amplitude of wave source disk, h be wave source disk center to the space any distance, j is plural variable, t is a time variable, and θ is wave source disk center to certain any the line and the angle of wave source disk normal.
The disk position distribution is calculated in distribution according to the wave source mechanical parameter, calculates the acoustic pressure of wave source again according to the sound wave principle of stacking:
When r＞＞during a, the integration that obtains p is:
Wherein:
Then, carry out the wave source METHOD FOR SOUND POWER CALCULATION
Whole wave source is combined by 300-500 sequin, and according to the sound wave principle of stacking, space arbitrarily any field intensity is the stack of this hundreds of sequin, and wherein any one sequin can be obtained by (3) formula at the spatial sound intensity, as shown in Figure 4.
The field intensity of any 1 A in space is:
Sequin is uniform distribution on the sphere of R at radius, and initial angle of distribution is Φ 1, and stopping angle of distribution is Φ 2, and the total number of disk is N.
The wave source parameter is as follows:
The static density of wave source frequency of vibration: f=1MHz: ρ 0=998kg/m3
The velocity of sound: c0=1483m/s
Wafer radius: a=6mm spherical radius: R=340mm
Circular frequency: ω=2 π f wave numbers: k=ω/c0
2. the temperature field distributes and calculates
The initial value of design temperature field (initial temperature be zero) at first, according to following calculating principle, by the distribution of difference iterative search techniques accounting temperature field:
During with the ultrasound wave heat tissue, the in-house equation of heat conduction is (supposing that biological tissue is an isotropism):
P wherein, C, κ are respectively effective density, specific heat, the heat conductivity of tissue, Wb and Cb are respectively the specific heat of blood flow rate and blood flow, and Tb is the blood heat that enters the thermal treatment zone, and T is a tissue temperature, Qm is the biological metabolism heat generation rate, and Qv is the volume thermal source that the acoustic energy conversion brings.
Before supposing heating, the each point temperature is T0 in the tissue, and the blood flow rate is Wb0, and the blood heat that enters the thermal treatment zone is irrelevant with heating, then has:
T
0-T
b＝Q
m/(W
b0C
b)
(7)
Introduce temperature rise
Variable: then the equation of heat conduction can turn to:
Suppose that the blood flow rate is constant, can not consider the influence of Qm, because sound field has axial symmetry, adopt cylindrical coordinates, the equation of heat conduction can be changed to:
Wherein,
Q
v＝(α/ρc)pp
* (10)
Solve an equation (9) with calculus of finite differences, can obtain the time dependent scattergram in temperature field.
In the actual therapeutic process, employing be to be interrupted emission, in emission intermittently the time, owing to there is not sound field to distribute, at this moment
Qv＝0。
Fig. 5 shows the flow chart of the theoretical temperatures of aforementioned calculation focus, in theoretical computing module, by changing parameters such as input electric power, emission parameter, tissue characteristics and target skin distance, use said method and obtain theoretical focal point temperature under the different condition to obtain the focus temp synopsis of heat therapy machine, and store resulting synopsis data, condition changing scope wherein is as shown in the table:
| Input electric power | Emission parameter | Tissue characteristics | Target skin distance |
| From 600w to 2000w, interval 100w | Launch time, intermittent time is from 150ms to 1000ms, 50 milliseconds at interval, emitting times is from 20 times to 100 times, 5 times at interval | Be divided into: liver, pancreas, bladder, rectum, prostate | From 50 millimeters to 130 millimeters, 10 millimeters at interval |
Because result of calculation may be variant with the actual focal spot temperature,, therefore need carry out some corrections to result of calculation according to the result of actual tests for the accuracy that guarantees to predict the outcome.Therefore, at temperature synopsis correcting module, the temperature synopsis of being stored is carried out correcting process.But because the condition of temperature computation is very many, actual tests can't be verified one by one to these different conditions, has therefore chosen several representative conditions and has revised.
The execution flow process of this correcting module is as follows:
1. obtain the actual focal spot temperature of different tissues under 1000w transmitting power condition by diminishing the thermometric experiment respectively;
2. the actual tests result is compared with the result of calculation of above-mentioned theory computing module,, then revise the characterisitic parameter of this tissue, recomputate, make it to be complementary with experimental result if inequality;
3. utilize characterisitic parameter to calculate revised focus temp synopsis again through revising.
Fig. 6 and Fig. 7 show the flow chart of temperature synopsis after the aforementioned calculation correction and the sketch map of prediction focus temp respectively.Before carrying out the HIFU treatment, the doctor will treat parameter input computer; By the focus temp query unit, computer output calculates the intravital sound field distribution of patient, change of temperature field situation; The doctor can meet expectation until the result according to result of calculation adjustment treatment parameter computation of table lookup again; After the selected treatment parameter, doctor's begin treatment.
Although invention has been described; but it the invention is not restricted to above-mentioned description taken together with the accompanying drawings just for illustrative purposes, and those of ordinary skills can not break away from the various changes of spirit of the present invention to it; in addition, protection scope of the present invention is limited by the accompanying Claim book.
Claims (7)
1. ultrasonic hyperthermia machine, it comprises: the high-energy concentration ultrasonic source, be installed on the B ultrasonic machine probe of wave source inside, computer and control station, wherein: described computer comprises the input block that is used to import the treatment parameter, link to each other with input block and to be used for inquiring about revised temperature synopsis to obtain the focus temp query unit of focus temp according to input parameter, and the output unit that is used to export described focus temp, and wherein said focus temp query unit comprises: the Theoretical Calculation module, be used to calculate theoretical focal point temperature under the different condition to obtain the focus temp synopsis of heat therapy machine, and temperature synopsis correcting module, be used for temperature revised theory temperature synopsis according to actual measurement.
2, ultrasonic hyperthermia machine according to claim 1, it is characterized in that described Theoretical Calculation module carries out following computing: according to the distribution situation of wave source disk, calculating wave source sound field distributes and distributes with the field distribution of difference iterative search techniques accounting temperature by the sound field that obtains.
3, ultrasonic hyperthermia machine according to claim 1 and 2 is characterized in that: select in the described input parameter group below: input electric power, emitter conversion efficiency, emission parameter, tissue characteristics, target skin distance, wave source characteristic.
4, a kind of heat therapy machine focus temp Forecasting Methodology, comprising following step:
To treat parameter by input block and be input to the focus temp query unit;
According to the condition of input, the revised focus temp synopsis that the inquiry of focus temp query unit is stored obtains focus temp;
Described focus temp is exported by output unit,
Revised temperature synopsis in the wherein said focus temp query steps obtains like this: at first calculate the theoretical focal point temperature under the different condition, to obtain the theoretical focal point temperature synopsis of heat therapy machine; According to the temperature of actual measurement, revised theory temperature synopsis; And store described revised temperature synopsis.
5, heat therapy machine focus temp Forecasting Methodology according to claim 4, it is characterized in that described theory of computation focus temp comprises: according to the distribution situation of wave source disk, step that calculating wave source sound field distributes and the step that distributes the accounting temperature field distribution by the sound field that obtains.
6, heat therapy machine focus temp Forecasting Methodology according to claim 5 is characterized in that described wave source sound field distribution process comprises that further using infinite element method calculates step that the wave source disk sound intensity distributes and the step of calculating the wave source sound intensity by stack.
7,, it is characterized in that selecting in the described input parameter group below: input electric power, emitter conversion efficiency, emission parameter, tissue characteristics, target skin distance, wave source characteristic according to the described heat therapy machine focus temp of any one claim Forecasting Methodology among the claim 4-6.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011397160A CN1160136C (en) | 2001-11-28 | 2001-11-28 | Ultrasonic wave heat therapeutic apparatus and focus temp. pre-measuring method |
| AU2002242588A AU2002242588A1 (en) | 2001-11-28 | 2002-03-15 | An ultrasonic heat therapeutic machine and a predicting method of focus's temperature |
| PCT/CN2002/000165 WO2003045498A1 (en) | 2001-11-28 | 2002-03-15 | An ultrasonic heat therapeutic machine and a predicting method of focus's temperature |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011397160A CN1160136C (en) | 2001-11-28 | 2001-11-28 | Ultrasonic wave heat therapeutic apparatus and focus temp. pre-measuring method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1358549A CN1358549A (en) | 2002-07-17 |
| CN1160136C true CN1160136C (en) | 2004-08-04 |
Family
ID=4675358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011397160A Expired - Lifetime CN1160136C (en) | 2001-11-28 | 2001-11-28 | Ultrasonic wave heat therapeutic apparatus and focus temp. pre-measuring method |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN1160136C (en) |
| AU (1) | AU2002242588A1 (en) |
| WO (1) | WO2003045498A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100401975C (en) * | 2004-06-04 | 2008-07-16 | 北京源德生物医学工程有限公司 | Supersonic inverting method for measuring temperature of human or animal body |
| EP2341839B1 (en) * | 2008-09-22 | 2015-10-21 | Vessix Vascular, Inc. | System for vascular ultrasound treatments |
| CN102284136B (en) * | 2011-05-11 | 2014-06-25 | 常州瑞神安医疗器械有限公司 | In-vitro program-controlled device for implantable medical appliance |
| EP2638932A1 (en) * | 2012-03-14 | 2013-09-18 | Theraclion | Device for therapeutic treatment and method for controlling a treatment device |
| CN109960293B (en) * | 2017-12-26 | 2021-07-20 | 深圳先进技术研究院 | Temperature control method, device and system for thermal therapy |
| CN109999376B (en) * | 2019-03-19 | 2021-06-29 | 深圳市声科生物医学研究院 | HIFU equipment control system and nondestructive temperature measurement method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2664819B1 (en) * | 1990-07-23 | 1994-04-29 | Edap Int | ULTRA-FAST EXTRACORPOREAL ULTRASONIC HYPERTHERMAL APPARATUS. |
| US5558092A (en) * | 1995-06-06 | 1996-09-24 | Imarx Pharmaceutical Corp. | Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously |
| CN1160135C (en) * | 1999-03-09 | 2004-08-04 | 北京源德生物医学工程股份有限公司 | Power ultrasonic transmitter for high-energy ultrasonic external focusing heat therapy machine |
-
2001
- 2001-11-28 CN CNB011397160A patent/CN1160136C/en not_active Expired - Lifetime
-
2002
- 2002-03-15 AU AU2002242588A patent/AU2002242588A1/en not_active Abandoned
- 2002-03-15 WO PCT/CN2002/000165 patent/WO2003045498A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002242588A1 (en) | 2003-06-10 |
| CN1358549A (en) | 2002-07-17 |
| WO2003045498A1 (en) | 2003-06-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20240252846A1 (en) | Ultrasound autofocusing using reflections | |
| CN1294881C (en) | Systems and methods for reducing secondary hot spots in a phased array focused ultrasound system | |
| US20120143100A1 (en) | Extended depth-of-focus high intensity ultrasonic transducer | |
| WO2016134581A1 (en) | Dual-frequency confocal superimposed focused ultrasonic spherical splitting array and control method for splitting focus points | |
| CN107913477B (en) | Excitation method, device, equipment and storage medium of array ultrasonic transducer | |
| Duryea et al. | Removal of residual cavitation nuclei to enhance histotripsy fractionation of soft tissue | |
| CN1584524A (en) | Supersonic inverting method for measuring temperature of human or animal body | |
| CN1160136C (en) | Ultrasonic wave heat therapeutic apparatus and focus temp. pre-measuring method | |
| Ellens et al. | Frequency considerations for deep ablation with high‐intensity focused ultrasound: a simulation study | |
| CN105938467B (en) | High intensity focused ultrasound three-dimensional temperature field simulation algorithm based on Gaussian function convolution | |
| Kyriakou | Multi-physics computational modeling of focused ultrasound therapies | |
| Li et al. | Estimation of HIFU induced lesions in vitro: Numerical simulation and experiment | |
| Qian et al. | Uniform tissue lesion formation induced by high-intensity focused ultrasound along a spiral pathway | |
| RU2015116812A (en) | HEAT REDUCTION IN CONSISTENT NEARBOARD FIELDS FOR HIGH-INTENSE FOCUSED ULTRASOUND | |
| CN1342502A (en) | Focusing ultrasonic source | |
| CN101683550B (en) | High-intensity focused ultrasound therapy apparatus and method for determining therapeutic parameters thereof | |
| Cao et al. | Patient‐specific 3‐dimensional model for high‐intensity focused ultrasound treatment through the rib cage: a preliminary study | |
| CN104582587A (en) | Ultrasonic probe having gradient information and device for ultrasonic diagnosis and treatment using same | |
| Li et al. | A study of heating duration and scanning path in focused ultrasound surgery | |
| Zhang et al. | Numerical simulation of the transient temperature field from an annular focused ultrasonic transducer | |
| Ishida et al. | Development and animal experiment of variable focusing HIFU system for prostate cancer treatment | |
| CN2503914Y (en) | Focused ultrasonic wave source | |
| Karzova et al. | Nonlinear effects in ultrasound fields of diagnostic-type transducers used for kidney stone propulsion: Characterization in water | |
| Gao et al. | Focusing through the rib cage for MR-guided transcostal FUS | |
| Ma et al. | Hybrid MPI-OpenMP Accelerated Euler-Lagrange Simulations of Microbubble Enhanced HIFU |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: BEIJING YUANDE BIOLOGICAL MEDICAL ENGINEERING CO., Free format text: FORMER NAME OR ADDRESS: YUANDE BIO-MEDICINE ENGINEERING STOCK CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 100176 No. 24 North Yongchang Road, Beijing economic and Technological Development Zone, Beijing Patentee after: Yuande Biological Medicine Engineering Co., Ltd., Beijing Address before: 100176 No. 24 North Yongchang Road, Beijing economic and Technological Development Zone, Beijing Patentee before: Yuande Bio-Medical Engineering Co., Ltd., Beijing |
|
| ASS | Succession or assignment of patent right |
Owner name: HAIFUNING HIGH STRONG ULTRASOUND TECHNOLOGY ( BEIJ Free format text: FORMER OWNER: BEIJING YUANDE BIOLOGY MEDICINE ENGINEERING CO., LTD. Effective date: 20090327 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20090327 Address after: Beijing City, Daxing District Xihongmen Zhen Fu Wei Road No. 8 Building No. 4, 1 - 2 Patentee after: Haifuning High-strength Ultrasonic Technology (Beijing) Co., Ltd. Address before: No. 24, Yongchang North Road, Beijing economic and Technological Development Zone, Beijing Patentee before: Yuande Biological Medicine Engineering Co., Ltd., Beijing |
|
| CX01 | Expiry of patent term |
Granted publication date: 20040804 |
|
| CX01 | Expiry of patent term |