CN116013532A - Tumor ablation parameter optimization system adopting pulsed electric field - Google Patents
Tumor ablation parameter optimization system adopting pulsed electric field Download PDFInfo
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Abstract
The invention discloses a tumor ablation parameter optimization system adopting a pulse electric field, and particularly relates to the technical field of tumor ablation, which comprises a control module, a processing module, a pulse electric field module, a pulse switch, a cloud data storage module and an ablation control module, wherein the control module is used for controlling a computer interface to set pulse parameters and send the pulse parameters to the processing module, the processing module scans tumors by utilizing three-dimensional ultrasonic waves and establishes a three-dimensional model according to tumor volume data, a data analysis is carried out on pulse parameter objects by utilizing a quadratic regression equation method according to the tumor volume data, and then pulse optimization parameters are obtained through an optimization function.
Description
Technical Field
The invention relates to the technical field of tumor ablation, in particular to a tumor ablation parameter optimization system adopting a pulse electric field.
Background
Along with the irregular life style and unhealthy eating habits brought by the pressure of life rhythm and work, the health of human beings is gradually endangered, tumors are one of main factors endangering the health of human beings, and through the continuous accumulation of tumor treatment experience for decades, treatment methods comprise surgical excision, radiation treatment, chemical treatment and physical ablation treatment, wherein the physical ablation treatment utilizes a method of eliminating local tumor straight-line tumors by utilizing a physical technology, the in-vivo trauma of a patient after treatment is reduced to the minimum by utilizing the help of an image guiding basis, electroporation ablation is one of modes of physical ablation treatment, and the electroporation ablation is to accelerate electric pulses on a specific electric threshold by a high-voltage pulse electric field, so that electroporation breaks a fast lipid bilayer, increases cell permeability, leads to unstable cell membranes and forms nanoscale holes, forces cell contents to be removed, and leads to cell death.
The current pulsed electric field tumor ablation system comprises a control module, a processor module, a pulsed electric field generator and an ablation device, wherein the control module sets parameters and controls the pulsed electric field generator according to the treatment requirements of patients through an authority user, the processor module receives the setting data of the control module and analyzes and processes the setting data to generate a pulse serial number, and the pulsed electric field generator generates specific electric pulses according to the pulse serial number and transmits the specific electric pulses to tumor tissues needing to be ablated through the ablation device to complete ablation treatment.
Although the electroporation ablation reduces the influence of the treatment side effect on important tissues and organs, the shape of the tumor is irregular and the distribution is uneven, so that the electroporation ablation causes uneven conductivity when the set parameters are inaccurate, the use difficulty is increased for an operator, the pain of a patient is increased, and the tumor cells are regenerated and recurred under the condition that the ablation effect is possibly uneven.
Disclosure of Invention
In order to overcome the defects in the prior art, the embodiment of the invention provides a tumor ablation parameter optimization system adopting a pulse electric field, and an optimization function is set by a parameter optimization module of a processing module to obtain an optimal value of the pulse parameter, so that a controllable ablation area is accurately eliminated according to the size of a tumor, the uniform effect of the pulse electric field ablation is improved, the use and operation difficulty of an operator is reduced, and the pain of a patient is reduced, so that the problems in the background art are solved.
In order to achieve the above purpose, the present invention provides the following technical solutions: the utility model provides a tumor ablation parameter optimizing system adopting pulsed electric field, which comprises a control module, a processing module, the pulsed electric field module, the pulse switch, cloud data storage module and ablation control module, control module is used for user control computer interface to set up and send to the processing module to pulse parameter, the processing module utilizes three-dimensional ultrasonic wave to scan the tumor and set up three-dimensional model according to tumor volume data, through utilizing the quadratic regression equation method to pulse parameter object according to tumor volume data carries out data analysis, then obtain pulse optimization parameter through optimizing function, processing module is connected with pulse switch simultaneously, be used for the safe early warning when the pulsed electric field starts, pulse electric field module is connected with processing module, pulse electric field module carries out pulse electric field output according to the pulse parameter optimization result of processing module, pulse electric field module includes energy storage unit and pulse control unit, energy storage unit is used for producing the continuous adjustable pulsed electric field that parameter optimization module corresponds, pulse control unit is connected with parameter optimization module, obtain the data after the energy storage unit and control the electric pulse that the energy storage unit output, pulse switch is connected with pulse control unit, be used for controlling pulse and the pulse and be used for controlling pulse and outputting when the pulse electric field to be started and the pulse switch is connected with the real-time, the pulse device is used for receiving the pulse, when the pulse is connected with the pulse electric switch is connected with the real-time to the pulse output, the pulse control module is used for receiving the pulse, the pulse output and the real-time pulse output signal is used for the pulse, and the pulse output device is used for the pulse and has been connected with the pulse control module and has been optimized, the tumor cell tissue is ablated by an electrode, which is a bipolar electrode.
In a preferred embodiment, the processing module includes a data acquisition module, a logic processing module, a parameter optimization module and a safety pre-warning module, the data acquisition module performs communication conversion with the processing module, the data acquisition module acquires an electric signal, converts the electric signal into a digital signal and then transmits the digital signal to the logic processing module, the digital signal includes a pulse parameter object, the logic processing module performs data analysis on the pulse parameter object by using a quadratic regression equation, and the parameter optimization module establishes a pulse parameter target formula for the pulse parameter object of pulse output and sets a limiting condition to optimize pulse electric field output pulse parameters.
In a preferred embodiment, the processing mode of the processing module specifically includes the following steps:
a10, firstly, acquiring the size of a tumor volume through a data acquisition module and establishing a tumor three-dimensional model;
a20, sequentially determining the pulse parameter objects to be optimized by a logic processing module through a hierarchical sequence method;
a30, then establishing a pulse parameter target formula;
and a40, setting a feasible threshold value for optimizing the pulse parameter value by the final parameter optimization module and optimizing a function to obtain the pulse optimal parameter.
The pulse parameter target formula:
H(y)＝a 0 +a 1 x 1 +a 2 x 2 +...+a i x i +...+a i-1 x i-1 x is M, wherein y is an optimized response value, x is a target variable value of a pulse parameter to be optimized, M is a feasible threshold value of a target variable of the pulse parameter to be optimized and is a natural number, i is the number of the pulse parameter variables, and a is a tumor volume value;
the optimization function:
wherein H (y) is a target formula of pulse parameters to be optimized, n is the number of target formulas of pulse parameters to be optimized and the number is more than or equal to2, setting an optimization function through a parameter optimization module to obtain an optimal value of the pulse parameter, so that a controllable ablation area is accurately eliminated according to the size of the tumor, and the uniform ablation effect of the pulse electric field is improved.
In a preferred embodiment, the processing module further includes a safety pre-warning module, which is used for collecting and analyzing the digital signal of the pulse voltage or current in the pulse discharging loop, and when the digital signal of the pulse electric field exceeds the expected setting range, the safety pre-warning device is started to stop the pulse electric field from outputting the power supply to protect the pulse electric field and feeding back to the authority user computer interface, so as to ensure the safe and stable operation of the pulse electric field.
In a preferred embodiment, the control module sets the pulse electric field parameters by the control interface of the authority user computer and sends the parameters to the micro-processing single chip, and the micro-processing single chip utilizes the editable logic element to complete the pulse electric field intensity control of the processing module, wherein the pulse electric field intensity is positively related to the tumor volume and the pulse width.
In a preferred embodiment, the pulse electric field module is composed of an energy storage unit and a pulse control unit, the energy storage unit comprises a high-voltage direct current power supply for providing pulse output for the pulse electric field, optical fiber isolation elements are added between all power supplies in the energy storage unit, so that the energy storage unit is charged in parallel in a charging state, and is discharged in series in a tail-to-tail mode in a discharging state, the pulse electric field module achieves the pulse multiplication effect and the pulse controllable requirement, the pulse control unit comprises a pulse generator and a protection circuit device, and the pulse generator outputs a proper pulse electric field according to the optimized value of the parameters of the processing module under the condition that the high-voltage direct current power supply provides the power output and is protected by the protection circuit device to run safely.
In a preferred embodiment, when the pulse switch is started, digital signals of pulse voltage or current in the electric pulse discharging loop output by the pulse electric field module are obtained and stored in the cloud data storage module, and the cloud data storage module classifies the digital signals according to pulse parameter types, so that data call of the processing module is facilitated.
In a preferred embodiment, the ablation control module comprises an ablation device, different electric pulse characteristics are generated according to optimized pulse parameters, ultra-fast electric pulses are applied to tumor cell tissues, so that the electric pulse perforation breaks a lipid bilayer of the tumor cells, the permeability of the tumor cells is increased, the tumor cell membranes are unstable and form nanoscale holes, the tumor cell contents are forced to die after being discharged, the operation difficulty of an operator is reduced, and the pain of a patient is reduced.
In a preferred embodiment, the method comprises the following specific steps:
step S10, firstly, the control module is used for controlling a computer interface to set pulse parameters by a user and sending the pulse parameters to the processing module;
step S20, secondly, the processing module scans the tumor by utilizing three-dimensional ultrasonic waves, establishes a three-dimensional model according to tumor volume data, performs data analysis on a pulse parameter object by utilizing a quadratic regression equation, and then obtains pulse optimization parameters by utilizing an optimization function;
step S30, the pulse electric field module outputs a pulse electric field according to the pulse parameter optimization result processed by the processing module;
and S40, finally, controlling the ablation control module by the pulse switch and transmitting data to the cloud data storage module.
The invention has the technical effects and advantages that:
the invention sets the optimizing function to obtain the optimal value of the pulse parameter by the parameter optimizing module of the processing module, so that the controllable fusion area is precisely eliminated according to the tumor size, the uniform effect of pulse electric field ablation is improved, the using and operating difficulty of an operator is reduced, and the pain of a patient is reduced.
Drawings
Fig. 1 is a block diagram of a system architecture of the present invention.
FIG. 2 is a flow chart of the system operation steps of the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Embodiments of the present application may be applied to computer systems/servers that are operational with numerous other general purpose or special purpose computing system environments or configurations. Examples of well known computing systems, environments, and/or configurations that may be suitable for use with the computer system/server include, but are not limited to: personal computer systems, server computer systems, thin clients, thick clients, hand-held or laptop devices, microprocessor-based systems, set-top boxes, programmable consumer electronics, network personal computers, small computer systems, mainframe computer systems, and distributed cloud computing technology environments that include any of the foregoing, and the like.
A computer system/server may be described in the general context of computer-system-executable instructions, such as program modules, being executed by a computer system. Generally, program modules may include routines, programs, objects, components, logic, data structures, etc., that perform particular tasks or implement particular abstract data types. The computer system/server may be implemented in a distributed cloud computing environment in which tasks are performed by remote processing devices that are linked through a communications network. In a distributed cloud computing environment, program modules may be located in both local and remote computing system storage media including memory storage devices.
Examples
The embodiment provides a tumor ablation parameter optimization system adopting a pulsed electric field as shown in fig. 1, which comprises a control module, a processing module, a pulsed electric field module, a pulse switch, a cloud data storage module and an ablation control module.
The control module is used for controlling the computer interface to set pulse parameters by a user and sending the pulse parameters to the processing module.
The processing module scans the tumor by utilizing three-dimensional ultrasonic waves, establishes a three-dimensional model according to tumor volume data, analyzes the pulse parameter object by utilizing a quadratic regression equation method according to the tumor volume data, obtains pulse optimization parameters by an optimization function, and is connected with the pulse switch at the same time for safety early warning when a pulse electric field is started.
The pulse electric field module is connected with the processing module, the pulse electric field module outputs a pulse electric field according to a pulse parameter optimization result processed by the processing module, the pulse electric field module comprises an energy storage unit and a pulse control unit, the energy storage unit is used for generating a continuous adjustable pulse electric field corresponding to the parameter optimization module, and the pulse control unit is connected with the parameter optimization module, acquires data after parameter optimization and controls electric pulses output by the energy storage unit.
The pulse switch is connected with the pulse control unit and used for controlling the opening and closing of the electric pulse output by the pulse electric field, the pulse switch acquires the digital signal of the ablation control module in real time and is used for feeding back the real-time parameter output by the electric pulse and storing the real-time parameter output to the cloud data storage module, and the pulse switch is simultaneously connected with the safety early warning module and used for receiving the instruction of the safety early warning module to timely close the output of the electric pulse.
The ablation device is connected with the pulse switch, and when the pulse switch is started, the ablation device receives electric pulses and transmits the electric pulses to the electrode, and tumor tissues are ablated through the electrode, wherein the electrode is a bipolar electrode.
The present embodiment provides a method for operating a tumor ablation parameter optimization system using a pulsed electric field as shown in fig. 2: the method comprises the following specific steps:
step S10, firstly, the control module is used for controlling a computer interface to set pulse parameters by a user and sending the pulse parameters to the processing module;
the embodiment needs to specifically explain that the control module sets the pulse electric field parameters by the control interface of the authority user computer and sends the parameters to the micro-processing single chip, and the micro-processing single chip utilizes the editable logic element to complete the pulse electric field intensity control of the processing module, wherein the pulse electric field intensity is positively related to the tumor volume and the pulse width.
Step S20, secondly, the processing module scans the tumor by utilizing three-dimensional ultrasonic waves, establishes a three-dimensional model according to tumor volume data, performs data analysis on a pulse parameter object by utilizing a quadratic regression equation, and then obtains pulse optimization parameters by utilizing an optimization function;
the embodiment needs to be specifically explained that the processing module comprises a data acquisition module, a logic processing module, a parameter optimization module and a safety early warning module, the data acquisition module performs communication conversion with the processing module, the data acquisition module acquires an electric signal, converts the electric signal into a digital signal and then transmits the digital signal to the logic processing module, the digital signal comprises a pulse parameter object, the logic processing module performs data analysis on the pulse parameter object by using a quadratic regression equation, and the parameter optimization module establishes a pulse parameter target formula for the pulse parameter object of pulse output and sets a limiting condition to optimize pulse electric field output pulse parameters.
The processing mode of the processing module specifically comprises the following steps of:
a10, firstly, acquiring the size of a tumor volume through a data acquisition module and establishing a tumor three-dimensional model;
a20, sequentially determining the pulse parameter objects to be optimized by a logic processing module through a hierarchical sequence method;
a30, then establishing a pulse parameter target formula;
and a40, setting a feasible threshold value for optimizing the pulse parameter value by the final parameter optimization module and optimizing a function to obtain the pulse optimal parameter.
The layered sequence method in step a20 is to sequence each pulse parameter object according to the order of the primary and secondary, then convert each optimization problem into a unified target optimization problem, the pulse parameter object x includes pulse electric field voltage, pulse width, pulse number and pulse output length, the pulse output length is in a proportional relation with the bipolar electrode length of the ablation device, and in step a30, the pulse parameter target formula is obtained by the following formula:
H(y)＝a 0 +a 1 x 1 +a 2 x 2 +...+a i x i +...+a i-1 x i-1 x is M, wherein y is an optimized response value, x is a target variable value of a pulse parameter to be optimized, M is a feasible threshold value of a target variable of the pulse parameter to be optimized and is a natural number, i is the number of the pulse parameter variables, and a is a tumor volume value; optimization function of step a 40:
in the formula, H (y) is a target formula of the pulse parameters to be optimized, n is the number of the target formulas of the pulse parameters to be optimized, and the number is more than or equal to 2, and an optimal value of the pulse parameters is obtained by setting an optimization function through a parameter optimization module, so that a controllable ablation area is accurately eliminated according to the size of a tumor, and the uniform effect of pulse electric field ablation is improved.
The processing module is used for collecting and analyzing the digital signals of the pulse voltage or the pulse current in the pulse discharging loop, and when the digital signals of the pulse electric field exceed the expected setting range, the safety precaution device is started to stop the pulse electric field from outputting a power supply to protect the pulse electric field and feeding the power supply back to the authority user computer interface, so that the safe and stable operation of the pulse electric field is ensured.
Step S30, the pulse electric field module outputs a pulse electric field according to the pulse parameter optimization result processed by the processing module;
the embodiment needs to be specifically explained that the pulse electric field module is composed of an energy storage unit and a pulse control unit, the energy storage unit comprises a high-voltage direct current power supply for providing pulse output for a pulse electric field, optical fiber isolation elements are added between all power supplies in the energy storage unit, the energy storage unit is charged in parallel in a charging state, and is discharged in series in a tail-to-tail mode in a discharging state, so that the pulse multiplication effect and the pulse controllable requirement are achieved, the pulse control unit comprises a pulse generator and a protection circuit device, and the pulse generator outputs a proper pulse electric field according to the optimized value of the processing module parameters under the condition that the high-voltage direct current power supply provides power output and is protected by the protection circuit device to run safely.
And S40, finally, controlling the ablation control module by the pulse switch and transmitting data to the cloud data storage module.
The embodiment needs to specifically explain that when the pulse switch is started, digital signals of pulse voltage or current in an electric pulse discharging loop output by the pulse electric field module are acquired and stored in the cloud data storage module, the cloud data storage module classifies the digital signals according to pulse parameter types, the data call of the processing module is convenient, the ablation control module comprises an ablation device, different electric pulse characteristics are generated according to optimized pulse parameters, ultra-fast electric pulses are applied to tumor cell tissues, so that the electric pulse perforation breaks a lipid bilayer of the tumor cells, the permeability of the tumor cells is increased, the tumor cell membranes are unstable and form nanoscale holes, the tumor cell contents are forced to die after being removed, the operation difficulty of an operator is reduced, and the pain of a patient is reduced.
Finally: the foregoing description of the preferred embodiments of the invention is not intended to limit the invention to the precise form disclosed, and any such modifications, equivalents, and alternatives falling within the spirit and principles of the invention are intended to be included within the scope of the invention.
Claims (9)
1. A tumor ablation parameter optimization system adopting a pulsed electric field is characterized in that: comprises a control module, a processing module, a pulse electric field module, a pulse switch, a cloud data storage module and an ablation control module, wherein the control module is used for controlling a computer interface to set pulse parameters by a user and sending the pulse parameters to the processing module, the processing module scans tumors by utilizing three-dimensional ultrasonic waves and establishes a three-dimensional model according to tumor volume data, a pulse parameter object is subjected to data analysis by utilizing a quadratic regression equation method according to the tumor volume data, then pulse optimization parameters are obtained by an optimization function, the processing module is simultaneously connected with the pulse switch and used for safety early warning when a pulse electric field is started, the pulse electric field module is connected with the processing module and outputs a pulse electric field according to a pulse parameter optimization result processed by the processing module, the pulse electric field module comprises an energy storage unit and a pulse control unit, the energy storage unit is used for generating a continuous adjustable pulse electric field corresponding to the parameter optimization module, the pulse control unit is connected with the parameter optimization module, acquires data after parameter optimization and controls electric pulses output by the energy storage unit, the pulse switch is connected with the pulse control unit and is used for controlling the opening and closing of the electric pulses output by the pulse electric field, the pulse switch acquires digital signals of the ablation control module in real time and is used for feeding back real-time parameters output by the electric pulses and storing the real-time parameters to the cloud data storage module, the pulse switch is simultaneously connected with the safety early warning module and is used for receiving an instruction of the safety early warning module to timely close the output of the electric pulses, the ablation device is connected with the pulse switch, the ablation device receives the electric pulses to be transmitted to the electrode when the pulse switch is started and ablates tumor cell tissues through the electrode, the electrode is a bipolar electrode.
2. A tumor ablation parameter optimization system employing pulsed electric fields as in claim 1, wherein: the processing module comprises a data acquisition module, a logic processing module, a parameter optimization module and a safety early warning module, wherein the data acquisition module and the processing module are in communication conversion, the data acquisition module acquires an electric signal and converts the electric signal into a digital signal, the digital signal is transmitted to the logic processing module, the digital signal comprises a pulse parameter object, the logic processing module performs data analysis on the pulse parameter object by utilizing a quadratic regression equation, and the parameter optimization module establishes a pulse parameter target formula for the pulse parameter object of pulse output and sets limiting conditions to optimize pulse electric field output pulse parameters.
3. A tumor ablation parameter optimization system employing pulsed electric fields as in claim 2, wherein: the processing mode of the processing module specifically comprises the following steps:
a10, firstly, acquiring the size of a tumor volume through a data acquisition module and establishing a tumor three-dimensional model;
a20, sequentially determining the pulse parameter objects to be optimized by a logic processing module through a hierarchical sequence method;
a30, then establishing a pulse parameter target formula;
and a40, setting a feasible threshold value for optimizing the pulse parameter value by the final parameter optimization module and optimizing a function to obtain the pulse optimal parameter.
The pulse parameter target formula:
H(y)＝a 0 +a 1 x 1 +a 2 x 2 +...+a i x i +...+a i-1 x i-1 x is M, wherein y is an optimized response value, x is a target variable value of a pulse parameter to be optimized, M is a feasible threshold value of a target variable of the pulse parameter to be optimized and is a natural number, i is the number of the pulse parameter variables, and a is a tumor volume value;
the optimization function:
in the formula, H (y) is a target formula of the pulse parameter to be optimized, n is the number of the target formulas of the pulse parameter to be optimized, and the number is more than or equal to 2.
4. A tumor ablation parameter optimization system employing pulsed electric fields as in claim 2, wherein: the processing module further comprises a safety early warning module which is used for collecting and analyzing the digital signals of the pulse voltage or the pulse current in the pulse discharging loop, and when the digital signals of the pulse electric field exceed the expected setting range, the safety early warning module is started to stop the pulse electric field to output a power supply to protect the pulse electric field and feed back the power supply to the authority user computer interface, so that safe and stable operation of the pulse electric field is ensured.
5. A tumor ablation parameter optimization system employing pulsed electric fields as in claim 1, wherein: the control module is used for setting the pulse electric field parameters by the control interface of the authority user computer and sending the pulse electric field parameters to the micro-processing single chip, and the micro-processing single chip utilizes the editable logic element to complete the pulse electric field intensity control of the processing module, wherein the pulse electric field intensity is positively related to the tumor volume and the pulse width.
6. A tumor ablation parameter optimization system employing pulsed electric fields as in claim 1, wherein: the pulse electric field module consists of an energy storage unit and a pulse control unit, wherein the energy storage unit comprises a high-voltage direct-current power supply for providing pulse output for a pulse electric field, optical fiber isolation elements are added between all power supplies in the energy storage unit, so that the energy storage unit is charged in parallel in a charging state, and is subjected to tail-end series discharge in a discharging state, the pulse multiplication effect and the pulse controllable requirement are achieved, the pulse control unit comprises a pulse generator and a protection circuit device, and the pulse generator outputs a proper pulse electric field according to the optimized value of the parameters of the processing module under the scene that the high-voltage direct-current power supply provides power output, and the protection circuit device protects the pulse electric field to safely operate.
7. A tumor ablation parameter optimization system employing pulsed electric fields as in claim 1, wherein: when the pulse switch is started, digital signals of pulse voltage or current in an electric pulse discharging loop output by the pulse electric field module are obtained and stored in the cloud data storage module, and the cloud data storage module classifies the digital signals according to pulse parameter types so as to facilitate data call of the processing module.
8. A tumor ablation parameter optimization system employing pulsed electric fields as in claim 1, wherein: the ablation control module comprises an ablation device, different electric pulse characteristics are generated according to optimized pulse parameters, and ultra-fast electric pulses are applied to tumor cell tissues, so that the electric pulse perforation damages a lipid bilayer of the tumor cells, the permeability of the tumor cells is increased, the tumor cell membranes are unstable and form nanoscale holes, and the tumor cell contents are forced to die after being discharged.
9. A process for optimizing the operation of a tumor ablation parameter using pulsed electric fields according to any one of claims 1-8, wherein: comprises the following specific steps:
step S10, firstly, the control module is used for controlling a computer interface to set pulse parameters by a user and sending the pulse parameters to the processing module;
step S20, secondly, the processing module scans the tumor by utilizing three-dimensional ultrasonic waves, establishes a three-dimensional model according to tumor volume data, performs data analysis on a pulse parameter object by utilizing a quadratic regression equation, and then obtains pulse optimization parameters by utilizing an optimization function;
step S30, the pulse electric field module outputs a pulse electric field according to the pulse parameter optimization result processed by the processing module;
and S40, finally, controlling the ablation control module by the pulse switch and transmitting data to the cloud data storage module.
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