CN115999082A - Ultrasonic treatment equipment - Google Patents
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- CN115999082A CN115999082A CN202211696665.1A CN202211696665A CN115999082A CN 115999082 A CN115999082 A CN 115999082A CN 202211696665 A CN202211696665 A CN 202211696665A CN 115999082 A CN115999082 A CN 115999082A
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- 238000009210 therapy by ultrasound Methods 0.000 title claims abstract description 20
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 47
- 230000005284 excitation Effects 0.000 claims abstract description 36
- 238000001514 detection method Methods 0.000 claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 8
- 238000002604 ultrasonography Methods 0.000 claims description 52
- 238000002560 therapeutic procedure Methods 0.000 claims description 15
- 230000005540 biological transmission Effects 0.000 description 7
- 238000010586 diagram Methods 0.000 description 4
- 238000002592 echocardiography Methods 0.000 description 3
- 230000000644 propagated effect Effects 0.000 description 2
- 206010046798 Uterine leiomyoma Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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Abstract
The invention provides ultrasonic treatment equipment, belongs to the technical field of ultrasonic treatment, and can at least partially solve the problem that the existing ultrasonic treatment equipment cannot accurately control the size, shape and energy of a focal zone. The ultrasonic treatment equipment comprises a plurality of ultrasonic transmitting units, a plurality of detecting units and a control module; the ultrasonic transmitting units are used for transmitting ultrasonic waves to one focus; the detection units are in one-to-one correspondence with the ultrasonic emission units, and each detection unit is arranged at the corresponding ultrasonic emission unit; the control module is used for controlling the ultrasonic transmitting unit and the detecting unit to carry out the following working procedures: each ultrasonic transmitting unit transmits excitation ultrasonic waves by taking the position to be treated as a focus, and each detecting unit records the infrasonic wave parameters of the received secondary sound waves; determining target parameters of therapeutic ultrasonic waves emitted by each ultrasonic emission unit according to preset focal domain parameters and infrasonic wave parameters; and each ultrasonic transmitting unit takes the position to be treated as a focus and transmits therapeutic ultrasonic waves according to target parameters.
Description
Technical Field
The invention belongs to the technical field of ultrasonic treatment, and particularly relates to ultrasonic treatment equipment.
Background
The high intensity focused ultrasound (HIFU, high Intensity Focused Ultrasound) technique refers to a technique of focusing ultrasound emitted from a plurality of ultrasound transmitting units (e.g., array elements) at one focal point (target point) so as to generate high intensity ultrasound in the vicinity of the focal point (focal region). For example, ultrasound waves may be focused at tissue to be treated in the human body to treat the tissue to be treated (e.g., deform diseased tissue), i.e., ultrasound treatment.
Accurate control of the size, shape, energy, etc. of the focal zone is important to improve the therapeutic effect, which requires that the ultrasound waves emitted by each ultrasound transmitting unit reach the required parameters of phase, amplitude, etc. at the focal point at the same time. However, the change of the ultrasonic parameters is related to the passing acoustic medium, and the human body is a complex non-uniform acoustic medium, so that the ultrasonic waves emitted by different ultrasonic emission units pass through the acoustic medium in the human body differently and are difficult to predict, and it is difficult to ensure that the ultrasonic waves emitted by each ultrasonic emission unit reach the required parameters at the focus at the same time.
Disclosure of Invention
The invention at least partially solves the problem that the prior ultrasonic treatment equipment cannot accurately control the size, shape and energy of a focal domain, and provides the ultrasonic treatment equipment capable of controlling the size, shape and energy of the focal domain more accurately.
In a first aspect, an embodiment of the present invention provides an ultrasound therapy device, including a plurality of ultrasound emission units, a plurality of detection units, and a control module;
the ultrasonic transmitting units are used for transmitting ultrasonic waves to one focus;
the detection units are in one-to-one correspondence with the ultrasonic emission units, and each detection unit is arranged at the corresponding ultrasonic emission unit;
the control module is used for controlling the ultrasonic transmitting unit and the detecting unit to carry out the following working procedures:
each ultrasonic transmitting unit transmits excitation ultrasonic waves by taking a position to be treated as a focus, and each detecting unit records infrasonic wave parameters of the received infrasonic waves; the tissue vibration at the excitation focus of the excitation ultrasonic energy emits the secondary sound wave;
determining target parameters of the therapeutic ultrasonic waves emitted by each ultrasonic emission unit according to the preset focal domain parameters and the infrasonic wave parameters; the therapeutic ultrasound energy treats tissue at a focal point;
and each ultrasonic transmitting unit takes the position to be treated as a focus, and transmits the treatment ultrasonic waves according to the target parameters.
Optionally, the ultrasonic transmitting unit and the corresponding detecting unit are of an integrated structure.
Optionally, the focal zone parameters include at least one of a shape, a size, and an energy of the focal zone.
Optionally, the infrasonic wave parameter includes at least one of a receiving time of the infrasonic wave and an amplitude of the infrasonic wave.
Optionally, the target parameter includes at least one of a phase and an amplitude of the therapeutic ultrasound.
Optionally, the focal zone parameters include a shape and a size of a focal zone;
the infrasonic wave parameters comprise the receiving time of the receiving of the infrasonic wave;
the target parameter includes a phase of the therapeutic ultrasound;
wherein the earlier the reception time is detected, the later the phase of the therapeutic ultrasonic wave of the ultrasonic transmitting unit corresponding to the detecting unit is.
Optionally, the total power of the excitation ultrasonic waves emitted by each ultrasonic emission unit is 1W to 10W;
the total power of the therapeutic ultrasonic waves emitted by each ultrasonic emission unit is 20W to 500W.
Optionally, the frequency of the excitation ultrasonic wave is between 500kHz and 10 MHz;
the therapeutic ultrasound has a frequency between 500kHz and 10 MHz.
Optionally, the plurality of ultrasonic transmitting units are divided into a first group and a second group, wherein the first group comprises the plurality of ultrasonic transmitting units, and the second group comprises the plurality of ultrasonic transmitting units;
the excitation ultrasonic waves emitted by the plurality of ultrasonic emission units of the first group have a first frequency;
the excitation ultrasonic waves emitted by the plurality of ultrasonic emission units of the second group have a second frequency, and the first frequency is not equal to the second frequency.
Alternatively, the excitation ultrasonic wave is a pulsed ultrasonic wave or a continuous ultrasonic wave.
In the invention, focused excitation ultrasonic waves are generated at the position to be treated through each ultrasonic emission unit so as to excite tissue vibration at the focus to emit secondary sound waves, the secondary sound waves received by each detection unit are generated at the focus (namely the position to be treated) and then propagated to the detection unit, and the propagation path of the secondary sound waves is the propagation path of the therapeutic ultrasonic waves emitted by the ultrasonic emission unit corresponding to the detection unit; therefore, each detection unit can be controlled to emit therapeutic ultrasonic waves with specific parameters (target parameters) according to the condition of the secondary sound waves, so that the therapeutic ultrasonic waves emitted by each detection unit can simultaneously and accurately reach the required parameters such as phase, amplitude and the like at the focus, and the size, shape and energy of a focus area can be controlled more accurately and effectively.
Drawings
FIG. 1 is a block schematic diagram of an ultrasonic treatment apparatus according to an embodiment of the present invention;
FIG. 2 is a block diagram schematically illustrating the constitution of another ultrasonic treatment apparatus according to an embodiment of the present invention
FIG. 3 is a schematic workflow diagram of an ultrasonic treatment apparatus according to an embodiment of the present invention;
fig. 4 is a schematic diagram showing the relationship between an ultrasonic transducer and a focal point in another ultrasonic treatment apparatus according to an embodiment of the present invention.
Detailed Description
The present invention will be described in further detail below with reference to the drawings and detailed description for the purpose of better understanding of the technical solution of the present invention to those skilled in the art.
It is to be understood that the specific embodiments and figures described herein are merely illustrative of the invention, and are not limiting of the invention.
It is to be understood that the various embodiments of the invention and the features of the embodiments may be combined with each other without conflict.
It is to be understood that, for convenience of description, only portions related to the embodiments of the present invention are shown in the drawings, and portions unrelated to the embodiments of the present invention are not shown in the drawings.
In High Intensity Focused Ultrasound (HIFU) treatment, ultrasound waves emitted from a plurality of ultrasound emitting units are focused at a tissue to be treated in a human body to treat the tissue (e.g., deform diseased tissue).
Accurate control of the size, shape, energy, etc. of the focal zone is important to improve the therapeutic effect, which requires that the ultrasound waves emitted by each ultrasound transmitting unit reach the required parameters of phase, amplitude, etc. at the focal point at the same time. However, the change of the ultrasonic parameters is related to the passing acoustic medium, and the human body is a complex non-uniform acoustic medium, so that the ultrasonic waves emitted by different ultrasonic emission units pass through the acoustic medium in the human body differently and are difficult to predict, and it is difficult to ensure that the ultrasonic waves emitted by each ultrasonic emission unit reach the required parameters at the focus at the same time.
In some related art, a "Time Reversal" technique is used to adjust the parameters of the ultrasound waves. For example, each ultrasonic transmitting unit is used for transmitting ultrasonic waves and recording received echoes respectively, and the echoes represent the conditions of acoustic media experienced by the ultrasonic transmitting units, so that parameters of the ultrasonic waves transmitted by the ultrasonic transmitting units can be correspondingly adjusted according to the echoes. However, the above "echo" is a reflected ultrasonic wave, and many tissues in the human body may cause reflection, so the echo is not necessarily reflected from the focal point, and thus the situation of the echo cannot accurately reflect the condition of the acoustic medium between the ultrasonic transmitting unit and the focal point, and it is still difficult to achieve accurate control of the focal domain size, shape, and energy according to the echo.
In a first aspect, an embodiment of the present invention provides an ultrasound therapy device.
The ultrasonic treatment device of the embodiment of the invention is used for carrying out high-intensity focused ultrasound (HIFU) treatment on a patient, for example, the treatment of benign and malignant tumors such as hysteromyoma and the like by deforming pathological tissues through the high-intensity focused ultrasound.
Referring to fig. 1, an ultrasonic therapy apparatus of an embodiment of the present invention includes a plurality of ultrasonic transmitting units, a plurality of detecting units, and a control module;
the ultrasonic transmitting units are used for transmitting ultrasonic waves to one focus;
the detection units are in one-to-one correspondence with the ultrasonic emission units, and each detection unit is arranged at the corresponding ultrasonic emission unit.
The ultrasonic treatment equipment of the embodiment of the invention comprises a plurality of ultrasonic emission units (array elements), wherein each ultrasonic emission unit is arranged at a preset position and can emit ultrasonic waves in a preset direction, and the ultrasonic waves emitted by each ultrasonic emission unit pass through the same point (focus), so that the ultrasonic waves emitted by the whole ultrasonic treatment equipment are focused ultrasonic waves at the focus.
For example, referring to fig. 4, an ultrasonic therapy device may include an ultrasonic transducer having an emitting surface for emitting ultrasonic waves in a variety of forms, which may be generally a portion of a sphere, such as a spherical cap surface, a spherical segment surface, two opposing spherical cap surfaces, etc., for facilitating focusing.
The ultrasonic transmitting units are 'array elements' arranged at the positions of the transmitting surface of the ultrasonic transducer, each array element can emit ultrasonic waves (such as to the spherical center of the spherical surface) relatively independently, namely, the focus of each ultrasonic transmitting unit can be the spherical center, the ultrasonic transducer can be a 'phased array ultrasonic transducer', and 'phased array ultrasonic focusing' can be realized.
Each ultrasonic transmitting unit is correspondingly provided with a detecting unit, the corresponding ultrasonic transmitting units and the detecting units are arranged at the same or close positions, and the detecting units are used for detecting received sound waves (including ultrasonic waves), so that the detecting units can actually detect the sound waves received by the corresponding ultrasonic transmitting units.
The ultrasonic transmitting unit may be any device capable of emitting sound, such as a piezoelectric device.
The detection unit may be any device capable of sensing sound, such as a piezoelectric device.
Optionally, the ultrasonic transmitting unit and the corresponding detecting unit are of an integral structure.
As a way of an embodiment of the present invention, referring to fig. 4, the corresponding ultrasonic transmitting unit and detecting unit may be a "device (e.g., a piezoelectric device)", which can emit ultrasonic waves under drive and sense received acoustic waves.
It should be understood that it is also possible if the corresponding ultrasound transmission unit and detection unit are mutually independent devices.
It should be understood that if it is also possible that a plurality of closely located array elements in the ultrasound transducer correspond to one and the same detection unit, then the plurality of array elements is regarded as one ultrasound transmission unit.
It should be understood that referring to fig. 2, other modules may be included in the ultrasound therapy device according to the embodiment of the present invention, such as a power module for providing a driving signal to each ultrasound transmitting unit to make it emit an ultrasound wave, a driving module for driving each ultrasound transmitting unit (ultrasound transducer) to move to change a specific position of a focus, a supporting module for supporting a patient's body (such as a treatment couch), a medium module for containing an acoustic medium (such as deaerated water), a purifying module for providing an acoustic medium (such as a deaerating device), etc., which will not be described in detail herein.
The specific form, number, positional relationship, etc. of the above modules are various, and will not be described in detail herein.
Referring to fig. 3, in the ultrasound therapy device according to the embodiment of the present invention, the control module is configured to control the ultrasound transmitting unit and the detecting unit to perform the following working procedures:
s101, each ultrasonic transmitting unit sends out excitation ultrasonic waves by taking the position to be treated as a focus, and each detecting unit records the infrasonic wave parameters of the received infrasonic waves.
Wherein the excitation ultrasonic energy excites tissue vibrations at the focal spot to emit secondary sound waves.
S102, determining target parameters of the therapeutic ultrasonic waves emitted by each ultrasonic emission unit according to the preset focal domain parameters and the infrasonic wave parameters.
Wherein the therapeutic ultrasound energy treats tissue at the focal spot.
S103, each ultrasonic transmitting unit takes the position to be treated as a focus, and transmits therapeutic ultrasonic waves according to target parameters.
In the embodiment of the invention, the control module can control other devices of the ultrasonic treatment equipment to work according to a specific working flow.
Firstly, a certain position in a human body (a position to be treated) can be determined through a B ultrasonic image, artificial designation and other modes, and each ultrasonic transmitting unit is controlled to take the position as a focus to emit focused excitation ultrasonic waves.
The energy of the excitation ultrasonic wave is small, and the tissue at the focus is not damaged, so that the treatment effect is not achieved; but the excitation of ultrasound waves causes the tissue at the focal point to vibrate, which in turn causes new sound waves, i.e., secondary sound waves, to be emitted.
Each detection unit can receive the above secondary sound wave and analyze and obtain various parameters (secondary sound wave parameters) related to the secondary sound wave.
Obviously, the secondary sound waves received by each detection unit are transmitted to the corresponding ultrasonic transmission unit after being transmitted from the focus (tissue to be treated), and the ultrasonic waves transmitted by the ultrasonic transmission unit are transmitted to the focus (tissue to be treated) from the ultrasonic transmission unit, so that the transmission paths of the two sound waves are identical (of course, opposite directions), and the experienced sound medium conditions are identical (of course, the sound medium must be specific to one tissue to be treated, and the patient cannot move in the process).
The ultrasonic waves emitted by each ultrasonic emission unit are theoretically focused on a focus, but a region with high energy, namely a 'focal region', is actually formed near the focus, or the focal region is a truly existing focal region, and in order to achieve a required therapeutic effect, the focal region needs to be matched with certain characteristics (focal region parameters).
Therefore, the control module can analyze and determine the acoustic medium condition experienced by the therapeutic ultrasonic waves emitted by each ultrasonic emission unit when the therapeutic ultrasonic waves are transmitted to the focus according to the above infrasonic wave parameters, and further determine (or adjust) what parameters (target parameters) the therapeutic ultrasonic waves emitted by the ultrasonic emission units should take, so that the condition of the focus area can meet the required focus area parameters.
Therefore, each ultrasonic transmitting unit can send out therapeutic ultrasonic waves according to the determined target parameters by taking the position to be treated as a focus later, and the energy of the therapeutic ultrasonic waves is higher, so that the tissue at the position to be treated can be treated.
In the invention, focused excitation ultrasonic waves are generated at the position to be treated through each ultrasonic emission unit so as to excite tissue vibration at the focus to emit secondary sound waves, the secondary sound waves received by each detection unit are generated at the focus (namely the position to be treated) and then propagated to the detection unit, and the propagation path of the secondary sound waves is the propagation path of the therapeutic ultrasonic waves emitted by the ultrasonic emission unit corresponding to the detection unit; therefore, each detection unit can be controlled to emit therapeutic ultrasonic waves with specific parameters (target parameters) according to the condition of the secondary sound waves, so that the therapeutic ultrasonic waves emitted by each detection unit can simultaneously and accurately reach the required parameters such as phase, amplitude and the like at the focus, and the size, shape and energy of a focus area can be controlled more accurately and effectively.
Optionally, the total power of the excitation ultrasonic waves emitted by each ultrasonic emission unit is 1W to 10W;
the total power of the therapeutic ultrasonic waves emitted by each ultrasonic emission unit is 20W to 500W.
As a mode of the embodiment of the invention, the sum of the power of the excitation ultrasonic waves emitted by all ultrasonic emission units can be 1-10W, further can be 2-8W, further can be 4-6W; when all ultrasonic transmitting units transmit therapeutic ultrasonic waves, the sum of the power used can be 20-500W, further can be 50-400W, and further can be 100-350W.
Alternatively, the frequency of the excitation ultrasonic wave is between 500kHz and 10 MHz;
the therapeutic ultrasound has a frequency between 500kHz and 10 MHz.
Correspondingly, the frequency of the excitation ultrasonic wave can be between 0.5 and 10MHz, further can be between 1 and 8MHz, and further can be between 2 and 6MHz; the frequency of the therapeutic ultrasonic wave can be between 0.5 and 10MHz, further between 1 and 8MHz, and further between 2 and 6MHz.
Optionally, the focal zone parameters include at least one of a shape, a size, and an energy of the focal zone.
As a way of an embodiment of the present invention, by adjusting the target parameter, the shape, size, energy, etc. of the focal domain can be specifically controlled, for example, the size of the focal domain is made smaller, the energy is higher, and a desired predetermined shape is formed.
Alternatively, the excitation ultrasonic wave is a pulsed ultrasonic wave or a continuous ultrasonic wave.
As one mode of the embodiment of the present invention, the excitation ultrasonic wave may be specifically a pulsed ultrasonic wave or a continuous ultrasonic wave.
As one mode of the embodiment of the present invention, the therapeutic ultrasound may be specifically pulsed ultrasound or continuous ultrasound.
Optionally, the infrasonic wave parameter includes at least one of a receiving time of the received infrasonic wave and an amplitude of the infrasonic wave.
As a way of an embodiment of the present invention, for a received infrasonic wave, its specifically detectable infrasonic wave parameters include its receiving time, amplitude, etc.
Optionally, the target parameter includes at least one of a phase and an amplitude of the therapeutic ultrasound.
As a mode of the embodiment of the invention, the target parameters such as the phase and the amplitude of the therapeutic ultrasonic waves can be specifically adjusted according to the required focal domain parameters and the detected infrasonic wave parameters.
Optionally, the plurality of ultrasound transmitting units are divided into a first group and a second group, the first group comprising the plurality of ultrasound transmitting units, the second group comprising the plurality of ultrasound transmitting units;
the excitation ultrasonic waves emitted by the plurality of ultrasonic emission units of the first group have a first frequency;
the excitation ultrasonic waves emitted by the plurality of ultrasonic emission units of the second group have a second frequency, and the first frequency is not equal to the second frequency.
As a mode of the embodiment of the present invention, all the ultrasonic transmitting units may be divided into two groups (for example, the numbers of the two groups of ultrasonic transmitting units may be the same or as close as possible and distributed as uniformly as possible), and when the excitation ultrasonic wave is emitted, the ultrasonic transmitting units of the same group may be controlled to emit the excitation ultrasonic wave with the same frequency, and the frequencies of the excitation ultrasonic waves emitted by the two groups of ultrasonic transmitting units are different, and are the first frequency and the second frequency respectively; in this way, ultrasonic waves of a "difference frequency" are formed at the focal point, and a dynamic acoustic radiation force is generated by using the ultrasonic waves of the "difference frequency" to drive the tissue at the focal point to vibrate, so that the vibration frequency of the tissue at the focal point is substantially equal to the frequency of the "difference frequency" above.
It should be appreciated that it is also possible to excite the ultrasound waves with a frequency to cause vibrations of the tissue, if by other means. For example, when the emitting surface of the ultrasonic transducer includes two opposing spherical surfaces, excitation ultrasonic waves emitted from one spherical surface may be reflected back by the other spherical surface, thereby forming a standing wave at the focal point, through which vibrations of tissue at the focal point may also be induced.
Optionally, the focal zone parameters include a shape and size of the focal zone;
the infrasonic wave parameters comprise the receiving time of receiving the infrasonic wave;
the target parameters include the phase of the therapeutic ultrasound;
wherein, the earlier the detected receiving time is, the later the phase of the therapeutic ultrasonic wave of the ultrasonic transmitting unit corresponding to the detecting unit is.
The distance between each ultrasonic transmitting unit and the focus is generally equal, so if the detecting units should receive the secondary sound wave substantially simultaneously in a uniform sound medium, if the time (receiving time) of each detecting unit receiving the secondary sound wave is different, the difference of the receiving times is caused by the difference of delays caused by the sound mediums at different positions.
For this reason, the phase of the therapeutic ultrasonic wave emitted by each ultrasonic emission unit may be adjusted "reversely" according to the order in which each detection unit (i.e., the ultrasonic emission unit) receives the secondary acoustic wave, that is, the earlier the detection unit that receives the secondary acoustic wave, the later the corresponding ultrasonic emission unit emits the therapeutic ultrasonic wave (i.e., the later the phase of the emitted therapeutic ultrasonic wave).
It should be understood that the phase of the ultrasonic transmitting unit in the embodiment of the present invention refers to the case of any one phase of the ultrasonic wave being emitted by each ultrasonic transmitting unit at the same time.
The different phases of the ultrasonic waves emitted by the ultrasonic emission units at the same moment can be realized by a plurality of different specific modes. For example, each ultrasonic transmitting unit may start to emit ultrasonic waves with different initial phases at the same time; alternatively, each ultrasonic emission unit may emit ultrasonic waves at the same initial phase, but the time for starting the emission of ultrasonic waves may be different.
It should be appreciated that in addition to controlling the size, shape, etc. of the focal zone by adjusting the phase of the therapeutic ultrasound, other focal zone parameters may be controlled by controlling other target parameters. For example, the energy (including the energy distribution) of the focal zone may be controlled by adjusting the amplitude of the therapeutic ultrasound waves emitted by each ultrasound transmission unit.
It is to be understood that the above embodiments are merely illustrative of the application of the principles of the present invention, but not in limitation thereof. Various modifications and improvements may be made by those skilled in the art without departing from the spirit and substance of the invention, and are also considered to be within the scope of the invention.
Claims (10)
1. An ultrasonic treatment device is characterized by comprising a plurality of ultrasonic emission units, a plurality of detection units and a control module;
the ultrasonic transmitting units are used for transmitting ultrasonic waves to one focus;
the detection units are in one-to-one correspondence with the ultrasonic emission units, and each detection unit is arranged at the corresponding ultrasonic emission unit;
the control module is used for controlling the ultrasonic transmitting unit and the detecting unit to carry out the following working procedures:
each ultrasonic transmitting unit transmits excitation ultrasonic waves by taking a position to be treated as a focus, and each detecting unit records infrasonic wave parameters of the received infrasonic waves; the tissue vibration at the excitation focus of the excitation ultrasonic energy emits the secondary sound wave;
determining target parameters of the therapeutic ultrasonic waves emitted by each ultrasonic emission unit according to the preset focal domain parameters and the infrasonic wave parameters; the therapeutic ultrasound energy treats tissue at a focal point;
and each ultrasonic transmitting unit takes the position to be treated as a focus, and transmits the treatment ultrasonic waves according to the target parameters.
2. The ultrasonic therapy apparatus according to claim 1, wherein,
the ultrasonic transmitting unit and the corresponding detecting unit are of an integrated structure.
3. The ultrasonic therapy apparatus according to claim 1, wherein,
the focal zone parameters include at least one of a shape, a size, and an energy of the focal zone.
4. The ultrasonic therapy apparatus according to claim 1, wherein,
the infrasonic wave parameters include at least one of a receiving time of receiving the infrasonic wave and an amplitude of the infrasonic wave.
5. The ultrasonic therapy apparatus according to claim 1, wherein,
the target parameter includes at least one of a phase and an amplitude of the therapeutic ultrasound.
6. The ultrasonic therapy apparatus according to claim 1, wherein,
the focal domain parameters comprise the shape and size of the focal domain;
the infrasonic wave parameters comprise the receiving time of the receiving of the infrasonic wave;
the target parameter includes a phase of the therapeutic ultrasound;
wherein the earlier the reception time is detected, the later the phase of the therapeutic ultrasonic wave of the ultrasonic transmitting unit corresponding to the detecting unit is.
7. The ultrasonic therapy apparatus according to claim 1, wherein,
the total power of the excitation ultrasonic waves emitted by the ultrasonic emission units is 1W to 10W;
the total power of the therapeutic ultrasonic waves emitted by each ultrasonic emission unit is 20W to 500W.
8. The ultrasonic therapy apparatus according to claim 1, wherein,
the frequency of the excitation ultrasonic wave is between 500kHz and 10 MHz;
the therapeutic ultrasound has a frequency between 500kHz and 10 MHz.
9. The ultrasonic therapy apparatus according to claim 1, wherein,
the plurality of ultrasonic transmitting units are divided into a first group and a second group, wherein the first group comprises the plurality of ultrasonic transmitting units, and the second group comprises the plurality of ultrasonic transmitting units;
the excitation ultrasonic waves emitted by the plurality of ultrasonic emission units of the first group have a first frequency;
the excitation ultrasonic waves emitted by the plurality of ultrasonic emission units of the second group have a second frequency, and the first frequency is not equal to the second frequency.
10. The ultrasonic therapy apparatus according to claim 1, wherein,
the excitation ultrasonic wave is pulse ultrasonic wave or continuous ultrasonic wave.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211696665.1A CN115999082A (en) | 2022-12-28 | 2022-12-28 | Ultrasonic treatment equipment |
| PCT/CN2023/129530 WO2024139720A1 (en) | 2022-12-28 | 2023-11-03 | Ultrasound therapy device |
| DE112023004092.3T DE112023004092T5 (en) | 2022-12-28 | 2023-11-03 | Ultrasound therapy device |
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| CN202211696665.1A CN115999082A (en) | 2022-12-28 | 2022-12-28 | Ultrasonic treatment equipment |
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| DE (1) | DE112023004092T5 (en) |
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| WO2024139720A1 (en) * | 2022-12-28 | 2024-07-04 | 重庆融海超声医学工程研究中心有限公司 | Ultrasound therapy device |
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| JP5091617B2 (en) * | 2007-10-23 | 2012-12-05 | 株式会社東芝 | Ultrasonic diagnostic apparatus and ultrasonic diagnostic apparatus control program |
| BR112012015620A2 (en) * | 2009-12-28 | 2017-10-17 | Koninl Philips Electronics Nv | magnetic resonance guided high intensity focused ultrasound ablation (hifu) therapy planning tool and method |
| US20150335919A1 (en) * | 2012-12-31 | 2015-11-26 | Perseus-Biomed Inc. | Phased array energy aiming and tracking for ablation treatment |
| US11464482B2 (en) * | 2013-03-04 | 2022-10-11 | Sunnybrook Research Institute | System and method for measuring and correcting ultrasound phase distortions induced by aberrating media |
| US20160008633A1 (en) * | 2013-03-06 | 2016-01-14 | Kobi Vortman | Frequency optimization in ultrasound treatment |
| EP3487583A1 (en) * | 2016-07-25 | 2019-05-29 | Insightec Ltd. | Ultrasound autofocusing using reflections |
| CN108310687A (en) * | 2018-03-13 | 2018-07-24 | 重庆医科大学 | A kind of online test method of focus ultrasonic sound field |
| WO2021123906A1 (en) * | 2019-12-18 | 2021-06-24 | Insightec, Ltd. | Adaptive single-bubble-based autofocusing and power adjustment in ultrasound procedures |
| CN115999082A (en) * | 2022-12-28 | 2023-04-25 | 重庆融海超声医学工程研究中心有限公司 | Ultrasonic treatment equipment |
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| WO2024139720A1 (en) * | 2022-12-28 | 2024-07-04 | 重庆融海超声医学工程研究中心有限公司 | Ultrasound therapy device |
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| Publication number | Publication date |
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| DE112023004092T5 (en) | 2025-07-17 |
| WO2024139720A1 (en) | 2024-07-04 |
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