CN115989013A

CN115989013A - Personal care compositions

Info

Publication number: CN115989013A
Application number: CN202180052763.9A
Authority: CN
Inventors: 罗伯特·格鲁伊特奇; 希亚马拉·皮莱
Original assignee: Colgate Palmolive Co
Current assignee: Colgate Palmolive Co
Priority date: 2020-08-31
Filing date: 2021-08-27
Publication date: 2023-04-18
Also published as: WO2022047111A1; EP4185264A1; US20230320966A1; MX2023002169A

Abstract

Described herein are aerosol compositions useful for deodorant and/or antiperspirant applications. Such compositions are substantially free of cyclomethicone. Methods of making and using the same are also described.

Description

Personal care compositions

Cross Reference to Related Applications

The present application claims priority from U.S. provisional patent application Ser. No. 63/072,391, filed 8/31/2020, which is incorporated herein by reference in its entirety.

Background

Washing, cleaning and caring for their own bodies are fundamental human needs, which modern industry is continually attempting to meet in various ways. It is particularly important for daily hygiene to eliminate or at least reduce body odour. Body odor is produced in large part by bacteria decomposing individual components of sweat on the skin.

Many specific deodorant and antiperspirant personal care products are known in the art that have been developed for body parts with high density sweat glands, particularly in the underarm and on the foot. These products have been formulated into various dosage forms such as stick, pump sprays, liquid and gel roll-on, pastes, soaked flexible substrates (towels), and aerosol sprays.

Aerosols are mixtures of a propellant and a base (base) mixture, which is also commonly referred to as a concentrate. A binder is a mixture of materials that are generally classified as volatile materials. Typical materials used in the binder are, for example, cyclomethicones such as decamethylcyclopentasiloxane (D5), or isododecane. However, due to the stability and difficulty of decomposition of cyclomethicone, its use has been determined by regulatory authorities to be potentially harmful to the environment.

There is a need for such aerosol deodorants and/or antiperspirants: it is substantially free or free of cyclomethicone and it can still produce excellent properties such as providing consumer sensory and efficacy benefits, providing a compact spray area, and imparting substantial deposition of active ingredients.

In some embodiments, the present invention addresses these previous technical problems. More particularly, the present invention relates to aerosol compositions useful in deodorant and/or antiperspirant applications, wherein such compositions are substantially free of cyclomethicone, or are free of cyclomethicone.

Disclosure of Invention

This summary is intended merely to introduce a simplified summary of some aspects of one or more embodiments of the present disclosure. Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter. This summary is not an extensive overview nor is intended to identify key or critical elements of the teachings, nor is it intended to delineate the scope of the disclosure. Rather, its sole purpose is to present one or more concepts in a simplified form as a prelude to the more detailed description that is presented later.

The present invention relates to deodorant and/or antiperspirant compositions that can be dispensed by aerosol. Accept the concept of: aerosol spray products consist of an aerosol concentrate or base, and a propellant or propellant mixture, and the weight% of a given material can be expressed as weight% in the concentrate or can, such that the weight% in both terms is reported. We will use this concept and report the wt% or range of wt% in the concentrate, then the wt% in the tank in brackets. And the ratio of 15 wt% concentrate in the tank to 85 wt% propellant in the tank will be used as an example, although the ratio may range from 5 wt% to about 50 wt% concentrate and from 50 wt% to about 95 wt% propellant.

Applicants have discovered a personal care composition comprising: having (CH 3)₂CH(CH2)_7-9CH₃Volatile compounds of (a); organic derivatives of hectorite clay; and a silicone-containing gum blend comprising polydimethylsiloxane and dimethiconol. Such compositions are free of, or substantially free of, cyclomethicone and are useful in applications as aerosols for deodorants and/or antiperspirants. In certain embodiments, the volatile compound is isododecane. In certain embodiments, the volatile compound is present in an amount of about 5 wt% to about 75 wt% (0.75 wt% to about 11.25 wt%), 5 wt% to about 60 wt% (0.75 wt% to about 9.0 wt%), 5 wt% to about 20 wt% (0.75 wt% to about 3.0 wt%), or 40 wt% to about 65 wt% (6.0 wt% to about 9.75 wt%). In certain embodiments, the personal care composition is according to any of the preceding embodiments, wherein the derivative of hectorite clay is selected from the group consisting of sela-ammonium chloride hectorite (stearalkonium hectorite), disteare-dimethylammonium hectorite (disteardimonium hectorite), and combinations thereof. In certain embodiments, the personal care composition is according to any preceding embodiment, wherein the derivative of hectorite clay is present in an amount of about 1 wt.% to about 5 wt.% (0.15 wt.% to about 0.75 wt.%), about 1 wt.% to about 4 wt.% (0.15 wt.% to about 0.60 wt.%), or about 2 wt.% to about 5 wt.% (0.30 wt.% to about 0.75 wt.%). In some cases In embodiments, the viscosity of the silicone-containing gum blend is from about 6,000cp to about 16,000cp at 25 ℃. In further embodiments, the silicone-containing gum blend is present in an amount of about 2 wt.% to about 15 wt.% (0.30 wt.% to about 2.25 wt.%), about 2 wt.% to about 10 wt.% (0.30 wt.% to about 1.50 wt.%), about 2 wt.% to about 8 wt.% (0.30 wt.% to about 1.20 wt.%), or about 6 wt.% to about 10 wt.% (0.90 wt.% to about 1.50 wt.%). In a preferred embodiment, the composition is substantially free of cyclomethicone, or is free of cyclomethicone. In certain embodiments, a personal care composition according to any preceding embodiment, wherein the composition further comprises an emollient, and wherein the emollient is optionally selected from the group consisting of isopropyl myristate, isopropyl palmitate, myristyl palmitate, polydimethylsiloxane, diheptyl succinate and caprylyl glycerol/sebacic acid copolymer, octyldodecanol, PPG-14 butyl ether, and C12-15 alkyl benzoate, and combinations thereof. In certain embodiments, the emollient is present in an amount of about 2 to about 40 wt% (0.30 to about 6.0 wt%), about 2 to about 25 wt% (0.30 to about 3.75 wt%), about 2 to about 10 wt% (0.30 to about 1.50 wt%), about 2 to about 8 wt% (0.30 to about 1.20 wt%), or about 4 to about 8 wt% (0.60 to about 1.20 wt%). In certain embodiments, the personal care composition according to any preceding embodiment, wherein the polydimethylsiloxane is present up to 16 weight percent (2.40 weight percent). In certain embodiments, the composition is selected from the group consisting of deodorants, antiperspirants, and combinations of two or more thereof. In certain preferred embodiments, the composition is an aerosol.

In a further embodiment, the invention is a method of treating, preventing or ameliorating a symptom associated with a disease, disorder or condition of keratinous materials, comprising administering to a keratinous material in a subject in need thereof a personal care composition according to any of the preceding embodiments. In certain embodiments, the keratinous material is chosen from: skin, hair, and combinations thereof.

In a further embodiment, the invention is a personal care composition comprising: organic derivatives of hectorite clay; a silicone-containing gum blend comprising polydimethylsiloxane and dimethiconol; wherein the polydimethylsiloxane is present up to 16% by weight of the composition. In certain embodiments, the derivative of hectorite clay is selected from the group consisting of sela-chloranite hectorite, disteardimonium hectorite, and combinations thereof. In certain embodiments, the derivative of hectorite clay is present in an amount of about 1 wt.% to about 5 wt.% (0.15 wt.% to about 0.75 wt.%), about 1 wt.% to about 4 wt.% (0.15 wt.% to about 0.60 wt.%), or about 2 wt.% to about 5 wt.% (0.30 wt.% to about 0.75 wt.%). In certain embodiments, the viscosity of the silicone-containing gum blend is from about 6,000cp to about 16,000cp at 25 ℃. In certain embodiments, the personal care composition is according to any one of the embodiments of this paragraph, and wherein the silicone-containing gum blend is present in an amount of from about 2 wt.% to about 15 wt.% (0.30 wt.% to about 2.25 wt.%), from about 2 wt.% to about 10 wt.% (0.30 wt.% to about 1.50 wt.%), or from about 2 wt.% to about 8 wt.% (0.30 wt.% to about 1.20 wt.%). In certain embodiments, the personal care composition is according to any one of the embodiments of this paragraph, and wherein the composition is substantially free of cyclomethicone, or is free of cyclomethicone. In certain embodiments, the personal care composition is according to any one of the embodiments of this paragraph, and wherein the composition further comprises an emollient, wherein the emollient is optionally selected from isopropyl myristate, isopropyl palmitate, myristyl palmitate, dimethicone, diheptyl succinate and caprylyl glycerol/sebacic acid copolymer, octyldodecanol, PPG-14 butyl ether, and C12-15 alkyl benzoate, and combinations thereof. In certain embodiments, the emollient is present in an amount of about 2 to about 40 wt% (0.30 to about 6.0 wt%), about 2 to about 25 wt% (0.30 to about 3.75 wt%), about 2 to about 10 wt% (0.30 to about 1.50 wt%), about 2 to about 8 wt% (0.30 to about 1.20 wt%), or about 4 to about 8 wt% (0.60 to about 1.20 wt%). In certain embodiments, the personal care composition is according to any one of the embodiments of this paragraph, and wherein the composition is selected from the group consisting of deodorants, antiperspirants, and combinations of two or more thereof. In certain preferred embodiments, the composition is an aerosol.

In a further embodiment, the invention is a method of treating, preventing or ameliorating a symptom associated with a disease, disorder or condition of keratinous material comprising administering to a keratinous material in a subject in need thereof a personal care composition according to any of the embodiments described in the preceding paragraphs. In further embodiments, the keratinous substance is chosen from: skin, hair, and combinations thereof.

In a further embodiment, the invention is a personal care composition comprising: having (CH 3)₂CH(CH2)_7-9CH₃Volatile compounds of (a); and a silicone-containing gum blend comprising polydimethylsiloxane and dimethiconol. In certain embodiments, the volatile compound is isododecane. In further embodiments, the volatile compound is present in an amount of about 5 wt% to about 75 wt% (0.75 wt% to about 11.25 wt%), 5 wt% to about 60 wt% (0.75 wt% to about 9.0 wt%), 5 wt% to about 20 wt% (0.75 wt% to about 3.0 wt%), or 40 wt% to about 65 wt% (6.0 wt% to about 9.75 wt%). In certain embodiments, the personal care composition is according to any one of the embodiments of this paragraph, and wherein the viscosity of the silicone-containing gum blend is from about 6,000cp to about 16,000cp at 25 ℃. In certain embodiments, the personal care composition is according to any one of the embodiments of this paragraph, and wherein the silicone-containing gum blend is present in an amount of from about 2 wt.% to about 15 wt.% (0.30 wt.% to about 2.25 wt.%), from about 2 wt.% to about 10 wt.% (0.30 wt.% to about 1.50 wt.%), or from about 2 wt.% to about 8 wt.% (0.30 wt.% to about 1.20 wt.%). In certain embodiments, the personal care composition is according to any one of the embodiments of this paragraph, and wherein the composition is substantially The composition is free of cyclomethicone or cyclomethicone. In certain embodiments, the personal care composition is according to any one of the embodiments of this paragraph, and wherein the composition further comprises an emollient, wherein the emollient is optionally selected from isopropyl myristate, isopropyl palmitate, myristyl palmitate, dimethicone, diheptyl succinate and caprylyl glycerol/sebacic acid copolymer, octyldodecanol, PPG-14 butyl ether, and C12-15 alkyl benzoate, and combinations thereof. In further embodiments, the emollient is present in an amount of about 2 to about 40 wt% (0.30 to about 6.0 wt%), about 2 to about 25 wt% (0.30 to about 3.75 wt%), about 2 to about 10 wt% (0.30 to about 1.50 wt%), about 2 to about 8 wt% (0.30 to about 1.20 wt%), or about 4 to about 8 wt% (0.60 to about 1.20 wt%). In certain embodiments, the personal care composition is according to any one of the embodiments of this paragraph, and wherein the polydimethylsiloxane is present up to 16 weight percent (2.40 weight percent). In certain embodiments, the personal care composition is according to any one of the embodiments of this paragraph, and wherein the composition is selected from the group consisting of deodorants, antiperspirants, and combinations of two or more thereof. In certain preferred embodiments, the composition is an aerosol.

In a further embodiment, the invention is a method of treating, preventing or ameliorating a symptom associated with a disease, disorder or condition of keratinous material comprising administering to a keratinous material in a subject in need thereof a personal care composition according to any of the preceding paragraphs. In certain embodiments, the keratinous material is chosen from: skin, hair, and combinations thereof.

Further areas of applicability of the present invention will become apparent from the detailed description provided hereinafter. It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.

Detailed Description

For purposes of illustration, the principles of the present invention are described by reference to various exemplary embodiments thereof. Although certain embodiments of the present invention have been specifically described herein, those of ordinary skill in the art will readily recognize that the same principles are equally applicable and can be used in other applications and methods. It is to be understood that the invention is not limited in its application to the details of any particular embodiment shown. The terminology used herein is for the purpose of description and not of limitation of the invention, its application or use.

As used herein and in the appended claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. The singular form of any of the ingredients of the classes refers not only to one of the chemicals in that class but also to mixtures of these chemicals. The terms "a" (or "an"), "one or more" and "at least one" can be used interchangeably herein. The terms "comprising," "including," and "having" are used interchangeably. The term "comprising" should be interpreted as "including, but not limited to. The term "comprising" should be interpreted as "including, but not limited to.

As used throughout, ranges are used as shorthand for describing the individual values and each value that are within the range. Any value within the range can be selected as the end of the range.

According to the present application, the term "about" means +/-5% of the reference value. As used herein, the term "substantially free" is intended to mean less than about 1% by weight of the composition; preferably less than about 0.5% by weight of the composition, and more preferably less than about 0.25% by weight of the composition. As used herein, the term "free" is intended to mean that no detectable amount is present in the composition.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. All patents, patent applications, publications, and other references cited or referred to herein are incorporated by reference in their entirety for all purposes. In the event of a conflict between a definition in the present disclosure and a definition of a cited reference, the present disclosure controls.

An "antiperspirant" is a composition that relieves body odor and prevents perspiration by affecting sweat glands. The antiperspirant may be applied to any part of the body and is typically applied to the underarm. In a preferred embodiment, the antiperspirant is applied to the axilla or foot of a person. The term "antiperspirant composition" refers to any composition that contains an antiperspirant active and is intended for application to the skin.

The term "antiperspirant efficacy" refers to the amount of wetting protection provided by the application of an antiperspirant composition to keratinous material of a subject, such as the underarm area (or armpit).

"deodorant" is a composition that is applied to the human body to prevent the body odor caused by bacterial breakdown of sweat. The deodorant may be applied to any part of the body. Under selected embodiments, the deodorant may be applied to the underarm and foot of a person.

The term "propellant" refers to one or more gases used to pressurize the antiperspirant composition to facilitate the expulsion of the antiperspirant composition from the container. Some propellants may be a gas mixture (e.g., a mixture of isobutane, butane, and propane). The propellant may be in the form of a liquid (i.e. liquefied gas) when under pressure within the reservoir of the injection device. Furthermore, the propellant may be in its gaseous state within the headspace of the reservoir. The propellant may be present in the reservoir in both liquefied form and its gaseous state. Unless otherwise indicated (e.g., liquid propellants or gaseous propellants), the term propellants are intended to encompass both liquefied and gaseous forms, individually and collectively.

The term "volatile" refers to materials having a boiling point (at atmospheric pressure) below 250 ℃ and/or a vapor pressure of about 0.1mm Hg at 25 ℃.

The personal care compositions of the present invention are useful as aerosols for deodorant and/or antiperspirant applications.

In certain embodiments, the personal care composition is anhydrous. The anhydrous composition is free of water, or substantially free of water. In preferred embodiments, the composition comprises water in an amount of less than 10.0 wt%, less than 5.0 wt%, less than 3.0 wt%, less than 1.0 wt%, less than 0.1 wt%, less than 0.05 wt%, less than 0.01 wt%, less than 0.005 wt%, or less than 0.0001 wt%, based on the total weight of the composition. In certain preferred embodiments, the composition has less than 1% by weight free water, less than 0.1% by weight free water, no free water, or no added water other than any water combined with the active antiperspirant ingredient.

The compositions of the present invention control sweat and optionally body odor from a localized area of the body (e.g., the armpit). In one embodiment, the present invention relates to a personal care composition comprising: having the formula (CH)₃)₂CH(CH₂)_7-9CH₃Volatile compounds of (a); derivatives of hectorite clay; and a silicone-containing gum blend comprising polydimethylsiloxane and dimethiconol. In certain embodiments, the volatile compound is isododecane. In certain embodiments, the volatile compound is present in an amount of about 15 wt% to about 75 wt% (2.25 wt% to about 11.25 wt%), about 15 wt% to about 60 wt% (2.25 wt% to about 9.0 wt%), or about 15 wt% to about 55 wt% (2.25 wt% to about 8.25 wt%).

In certain embodiments, the derivative of hectorite clay is a modified clay, e.g., C_10-22Ammonium chloride-modified hectorite, distearyldimethylammonium chloride-modified hectorite, e.g., as described under the trade name

27 or

38 (Elementis plc). In certain embodiments, the derivative of hectorite clay is selected from the group consisting of sela-chloranite hectorite, disteardimonium hectorite, and combinations thereof. In certain embodiments, the derivative of hectorite clay is present in an amount of about 2 wt.% to about 20 wt.% (0.3 wt.% to about 3.0 wt.%), 2 wt.% to about 10 wt.% (0.3 wt.% to about 1.5 wt.%) An amount of from 2 wt% to about 5 wt% (0.3 wt% to about 0.75 wt%), from 3 wt% to about 10 wt% (0.45 wt% to about 1.5 wt%), from about 3 wt% to about 8 wt% (0.45 wt% to about 1.2 wt%), or from about 3 wt% to about 6 wt% (0.45 wt% to about 0.9 wt%).

The personal care compositions of the present invention comprise a gum blend. Gum blend materials are used because they are typically heavier in weight than volatile materials and thus can enhance delivery of the personal care composition to the desired area. For example, the gum blend material may provide adhesion of the base mixture to the skin. The gum blend material may include a polydimethyl siloxane alcohol (a viscous material dispersed in, for example, cyclomethicone or dimethicone). In certain embodiments, the viscosity of the silicone-containing gum blend is from about 6,000cp to about 16,000cp at 25 ℃. In certain embodiments, the silicone-containing gum blend is present in an amount of about 2 wt.% to about 15 wt.% (0.3 wt.% to about 2.25 wt.%), about 2 wt.% to about 10 wt.% (0.3 wt.% to about 1.5 wt.%), about 2 wt.% to about 8 wt.% (0.3 wt.% to about 1.2 wt.%), about 4 wt.% to about 10 wt.% (0.6 wt.% to about 1.5 wt.%), or about 4 wt.% to about 8 wt.% (0.6 wt.% to about 1.2 wt.%).

In certain embodiments, the composition is substantially free of cyclomethicone. In certain embodiments, the composition is free of cyclomethicone.

In certain embodiments, the composition further comprises an emollient. In certain embodiments, the emollient may comprise an alkyl ester oil or alkyl-aryl ester oil having a boiling point above 150 ℃ and a melting point below 20 ℃. Such ester oils include oils containing one or two alkyl groups of 12 to 24 carbon atoms in length, including isopropyl myristate, isopropyl palmitate and myristyl palmitate. Other ester oils include alkyl or aryl benzoates, e.g. C benzoate_12-15Alkyl esters, e.g.

TN or->

Sun. In certain embodiments, the emollient is selected from isopropyl myristate, isopropyl palmitate, myristyl palmitate, polydimethylsiloxane,/->

TN、/>

Sun, diheptyl succinate and caprylyl glycerol/sebacic acid copolymer (in LexFeel^TMN50, inolex, inc., sold), octyldodecanol, PPG-14 butyl ether, or a combination thereof. In certain embodiments, the emollient is present in the following amounts: about 2 wt% to about 40 wt% (0.3 wt% to about 6.0 wt%), about 2 wt% to about 30 wt% (0.3 wt% to about 4.5 wt%), about 2 wt% to about 25 wt% (0.3 wt% to about 3.75 wt%), about 2 wt% to about 10 wt% (0.3 wt% to about 1.5 wt%), about 2 wt% to about 8 wt% (0.3 wt% to about 1.2 wt%), about 4 wt% to about 8 wt% (0.6 wt% to about 1.2 wt%), about 6 wt% to about 20 wt% (0.9 wt% to about 3.0 wt%), or about 6 wt% to about 15 wt% (0.9 wt% to about 2.25 wt%). In certain embodiments, the emollient is isopropyl palmitate and is present in the following amounts: about 2 wt% to about 40 wt% (0.3 wt% to about 6.0 wt%), about 2 wt% to about 30 wt% (0.3 wt% to about 4.5 wt%), about 2 wt% to about 25 wt% (0.3 wt% to about 3.75 wt%), about 2 wt% to about 10 wt% (0.3 wt% to about 1.5 wt%), about 2 wt% to about 8 wt% (0.3 wt% to about 1.2 wt%), about 4 wt% to about 8 wt% (0.6 wt% to about 1.2 wt%), about 5 wt% to about 20 wt% (0.75 wt% to about 3.0 wt%), or about 6 wt% to about 15 wt% (0.9 wt% to about 2.25 wt%).

In some embodiments, the personal care composition further comprises a gelling agent and/or an emollient. Examples of other gellants/emollients include, but are not limited to, waxes, esters of fatty acids and fatty alcohols, triglycerides, partially or fully hydrogenated soybean oil, partially or fully hydrogenated castor oil, other partially or fully hydrogenated vegetable oils, stearyl alcohol, propylene carbonate, or other cosmetically acceptable materials that are solid or semi-solid at room temperature and provide a consistency suitable for application to the skin.

In certain embodiments, the composition is selected from the group consisting of deodorants, antiperspirants, and combinations thereof. In certain embodiments, the composition is an aerosol.

The personal care compositions of the present invention utilize one or more active antiperspirant ingredients. In some embodiments, the at least one active antiperspirant ingredient is selected from the group consisting of aluminum salts, zirconium salts, and zinc salts. Any known aluminum-containing antiperspirant active may be used in the compositions of the present invention. Antiperspirant actives include but are not limited to, aluminum chloride, aluminum chlorohydrate polyethylene glycol, aluminum chlorohydrate propylene glycol, aluminum dichloride, aluminum chlorohydrate polyethylene glycol, aluminum dichlorohydrate propylene glycol, aluminum sesquichloride polyethylene glycol, aluminum sesquichloride propylene glycol zirconium aluminum hydroxychloride, zirconium aluminum hydroxychloride glycerol, zirconium aluminum zirconium hydroxychloride, zirconium aluminum hydroxychloride, glycerol aluminum zirconium hydroxychloride, and combinations thereof. In some embodiments, the active ingredient is aluminum hydroxychloride, aluminum zirconium hydroxychloride, and mixtures thereof. In certain embodiments, the antiperspirant ingredients are preferably present in the compositions of the present invention in an amount of from about 2% to about 60% (0.6% to about 9.0%, from about 8% to about 55% (1.2% to about 8.25%) by weight, from about 10% to about 50% (1.5% to about 7.5%), from about 20% to about 50% (3.0% to about 7.5%), or from about 30% to about 50% (4.5% to about 7.5%) by weight), based on the total weight of the composition, the antiperspirant active may be incorporated in the composition in an amount of from 0.5% to 25% (based on the active) of the final composition, but the amount will depend on the formulation of the composition.

In certain embodiments, the composition may comprise any known deodorant active. Examples of deodorant actives include, but are not limited to, antimicrobial actives, alcohols, 2,4 '-trichloro-2' -hydroxydiphenyl ether (triclosan), phenethylammonium chloride, polyhexamethylene biguanide, triethyl citrate, 2-amino-2-methyl-1-propanol (AMP), cetyltrimethylammonium bromide, cetylpyridinium chloride

Farnesol (3, 7, 11-trimethyl-2, 6, 10-dodecatrien-1-ol), N- (4-chlorophenyl) -N' - (3, 4-dichlorophenyl) urea (triclocarban), silver halide, octoxyglycerol (sensiva. Tm. Sc 50), and various zinc salts (e.g., zinc ricinoleate), bactericides and/or bacteriostats. The deodorant active may be included in the composition, for example, in an amount of from 0 wt% to 5 wt% or from 0.01 wt% to 1 wt%, based on the total weight of the propellant-containing composition.

Additional components of the antiperspirant composition optionally include any component known in the art to be suitable for use in such compositions. Optionally, the composition further comprises one or more ingredients selected from the group consisting of: fragrances, preservatives, emulsifiers, antioxidants and emollients.

In certain embodiments, the personal care composition comprises a preservative. Examples of suitable preservatives include benzyl alcohol, piroctone olamine, phenoxyethanol, parabens (parabens), pentanediol, benzoic acid/sodium benzoate, sorbic acid/potassium sorbate, and other organic acids used to provide antimicrobial protection. The preservative promoting ingredients include anisoic acid, lactic acid, sorbitan octoate, ethylhexyl glycerol, xin Xianyi glycol, octanediol, and the like. Suitable preservatives are those having a "preservative" function as set out in International cosmetic ingredient dictionary and handbook (International Cosmetic Ingredient Dictionary and Handbook) 9 th editionIs a substance of (a). In at least one embodiment, the preservative is selected from the group consisting of phenoxyethanol, benzyl paraben, butyl paraben, ethyl paraben, isobutyl paraben, isopropyl paraben, methyl paraben, propyl paraben, iodopropynyl butylcarbamate, methyl dibromoglutaronitrile, DMDM hydantoin, and combinations thereof. In at least one embodiment, the composition comprises a preservative selected from the group consisting of: cetyl trimethyl ammonium chloride and cetyl pyridinium chloride

Benzylmethoxyethylammonium chloride, diisobutylethoxyethyldimethylbenzyl ammonium chloride, N-laurylsarcosine sodium, N-palmitoylsarcosine sodium, lauroyl sarcosine, N-myristoyl glycine, N-laurylsarcosine potassium, trimethylammonium chloride, aluminum sodium hydroxychloride chloride, triethyl citrate, tricetyl methyl ammonium chloride, 2, 4' -trichloro-2 ' -hydroxydiphenyl ether (triclosan), phenoxyethanol, 1, 5-pentanediol, 1, 6-hexanediol, 3, 4' -trichlorocarbanilide (triclocarban), diaminoalkylamide, L-lysine hexadecylamide, heavy metal citrate, salicylate, piroctone (piroctose), zinc salts, hydroxypyridylthione and its heavy metal salts, zinc pyrithione, zinc phenol sulfate, farnesol, ketoconazole, oxiconazole, bifonazole, sulfenitrol, fluconazole, triclosan-methyl butoconazole, chloroconazole, clotrimazole, econazole, enconazole, fenticonazole, isoconazole, miconazole, sulconazole, tioconazole, fluconazole, itraconazole, terconazole, naftifine, terbinafine, selenium disulfide, octopirox (octopirox. RTM.), methyl chloroisothiazolinone, methyl isothiazolinone, methyl dibromoglutaronitrile, agCl, chloroxylenol, sodium salt of diethylhexyl sulfosuccinic acid, sodium benzoate, phenoxyethanol, benzyl alcohol, phenoxyisopropanol, nipagin esters (such as butylnipagin ester, ethylnipagin ester, methylpnipagin ester and propylnipagin ester) and salts thereof, pentanediol, 1, 2-octanediol, ethylhexyl glycerol, benzyl alcohol, sorbic acid, benzoic acid, lactic acid, imidazolidinyl urea, diazolidinyl urea, dimethylol dimethyl hydantoin (DMDMH), sodium hydroxymethylglycine Salts, hydroxyethylglycine of sorbic acid, and combinations thereof. In at least one embodiment, the preservative is selected from the group consisting of phenoxyethanol, benzyl ester nipagin, butyl nipagin, ethyl nipagin, isobutyl nipagin, isopropyl nipagin, methyl nipagin, propyl nipagin, iodopropynyl butylcarbamate, methyl dibromoglutaronitrile, DMDM hydantoin, and combinations thereof. In certain embodiments, the preservative is present in an amount of about 0.1 wt.% to about 5 wt.% (0.015 wt.% to about 0.75 wt.%), about 0.5 wt.% to about 3 wt.% (0.075 wt.% to about 0.45 wt.%), about 0.7 wt.% to about 1.5 wt.% (0.105 wt.% to about 0.225 wt.%) or about 0.1 wt.% to about 1.5 wt.% (0.015 wt.% to about 0.225 wt.%). />

In certain embodiments, the personal care composition further comprises a polysaccharide. In certain embodiments, the polysaccharide comprises levan, inulin, xanthan gum, guar gum, alginate, xylose, carboxymethyl cellulose, and combinations thereof. In certain embodiments, the polysaccharide is present in an amount of about 0.01 wt.% to about 5 wt.% (about 0.0015 wt.% to about 0.75 wt.%), about 0.05 wt.% to about 3 wt.% (0.0075 wt.% to about 0.45 wt.%), about 0.05 wt.% to about 1 wt.% (about 0.0075 wt.% to about 0.15 wt.%) or about 0.05 wt.% to about 0.8 wt.% (about 0.0075 wt.% to about 0.12 wt.%).

In certain embodiments, the personal care composition further comprises a humectant. In certain embodiments, the humectant is selected from: glycerol; butyl octanol; hyaluronic acid; urea; sodium lactate; propylene glycol; glycolic acid; sorbitol; and combinations of two or more thereof. In further embodiments, the humectant is selected from glycerin; butyl octanol; and combinations thereof. In some embodiments, the humectant is present in an amount of about 0.05 wt% to about 10 wt% (about 0.0075 wt% to about 1.5 wt%), about 1 wt% to about 8 wt% (about 0.15 wt% to about 1.2 wt%), or about 5 wt% to about 8 wt% (about 0.75 wt% to about 1.2 wt%). In some embodiments, the humectant is butyl octanol. In certain embodiments, the humectant is 2-butyloctanol. In certain embodiments, butyl octanol may be present in an amount of about 0.01 wt.% to about 8 wt.% (about 0.0015 wt.% to about 1.2 wt.%) based on the total weight of the personal care composition. In some embodiments, butyl octanol may be present in an amount of about 1 wt.% to about 8 wt.% (about 0.15 wt.% to about 1.2 wt.%) based on the total weight of the personal care composition. In some embodiments, butyl octanol may be present in an amount of about 5 wt.% to about 8 wt.% (about 0.75 wt.% to about 1.2 wt.%) based on the total weight of the personal care composition. In some embodiments, butyl octanol may be present in an amount of up to 8 weight percent, based on the total weight of the personal care composition. In some embodiments, butyl octanol may be present in an amount of up to 7 weight percent, based on the total weight of the personal care composition.

The aerosol composition is packaged in a dispenser that includes an aerosol container capable of topically dispensing the composition to the armpit area of a subject. Such containers are known in the art. Typically, the container is a pressurized aerosol container.

The composition may further comprise at least one propellant which is a liquefied gas, typically a liquefied hydrocarbon, such as one or more of butane, propane and isobutane, for example a mixture of these three propellant components. The at least one propellant is typically present in an amount of about 50 wt% to 95 wt%, such as about 85 wt%, based on the total weight of the composition.

The droplet size distribution of the aerosol can be measured using a Malvern spray tec instrument (Malvern Analytical, malvern, UK) and using laser diffraction techniques. In a preferred embodiment, the droplet size distribution should be no greater than 125 μm, preferably no greater than 100 μm, more preferably no greater than 80 μm. In a preferred embodiment, the droplet size distribution should be no less than 5 μm, more preferably no less than 3 μm. This is to ensure that the drop percentage of the product spray is not too small (which may be detrimental to consumer health).

The present invention also relates to a method of preventing or improving body taste and/or wetness comprising applying a personal care composition according to any of the embodiments described herein to the skin or keratinous surface of a subject in need thereof. In certain embodiments of the method, the keratinous surface is selected from: skin, hair, and combinations of two or more thereof.

In some embodiments, the present invention also relates to methods of treating, preventing, or ameliorating a symptom associated with a disease, disorder, or condition of keratinous material, comprising administering to a keratinous material in a subject in need thereof a personal care composition according to any of the embodiments described herein. In some embodiments, the disease, disorder or condition of keratinous material is selected from: body taste or sweating. In some embodiments, the keratinous material is chosen from skin, hair, and combinations thereof.

In some embodiments, the personal care compositions described herein further comprise linseed oil. In further embodiments, the personal care compositions described herein further comprise a natural oil selected from the group consisting of: almond oil; olive oil, etc. In some embodiments, the personal care compositions described herein comprise aloe leaf juice.

The following examples further describe and demonstrate illustrative embodiments within the scope of the present invention. These examples are given solely for the purpose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention. Various modifications of the invention, in addition to those shown and described herein, should be apparent to those skilled in the art, and are intended to fall within the scope of the appended claims.

Examples

Example 1

Embodiment compositions and properties. Aerosol performance was evaluated for compositions comprising isododecane, isopropyl palmitate, and polydimethylsiloxane in dimethiconol. Briefly, to determine the spray area, the aerosol was sprayed for 3 seconds from a distance of 6 "onto a piece of 10" x 10 "plexiglass (plexiglass). The diameter of the spray profile was measured in centimeters in the horizontal and vertical directions of the plexiglas. The average of the two diameters is then applied to the formula pi r²To determine the area of the circle due toA circular deposit is produced for the spray. This is an important parameter, as a more compact, smaller spray area means that more spray is directed under the armpit, providing a more efficient product.

To determine the deposition amount, a similar procedure to the spray pattern scheme was performed, except that a piece of black cloth was bound to the plexiglas sheet. The cloth was weighed before and after spraying the can contents onto the cloth. Likewise, the canister is weighed before and after the injection event. The time of injection was also measured. Taking the weight difference of the tank will indicate how much is ejected from the tank. The difference in weight of the cloth is taken to account for how much spray falls on the target area. The weight difference of the product deposited on the cloth was divided by the weight difference dispensed from the tank and multiplied by 100 to give the% of the product deposited. This is an important parameter as it indicates how much concentrate (the part of the can product containing antiperspirant and malodour-preventing active) is directed to the underarm area and provides an indication of the efficacy of the sample.

The viscosity was measured at 25 ℃. The results are shown in table 1. Ideally, it is desirable to maximize the amount of deposited product while minimizing spray area while achieving a balance in the level of viscosity that can be charged into the tank. When these statistical results are analyzed with the above limitations, a small window of favorable material levels is found that provides the desired results.

TABLE 1

Example 2

Evaluating aerosol performance for a composition comprising a) Isododecane (IDD), and one or more of: b) Isopropyl palmitate (IPP), c) polydimethylsiloxane, d) dimethiconol in polydimethylsiloxane

3096 Viscosity at 25℃is 600 mpa.s; or->

1020 Viscosity at 25℃of 160 mPa.s, wacker), e) C in dimethiconol_11-13Isoparaffins, isohexadecane and polydimethylsiloxane (PMX-1502, dow) and f) polydimethylsiloxane and dimethiconol (PMX-1503, viscosity at 25 ℃ C. Of 1395mPa.s, dow). Samples were analyzed as described above. The results are shown in (below) table 2.

TABLE 2

The use of IDD and IPP alone provides a large spray area and low sediment concentration. Surprisingly, the composition with the addition of dimethiconol in the dimethicone improved both the spray area and the deposited concentrate. In addition, the higher viscosity of the dimethiconol in dimethicone solution provides a more compact spray area and high deposition. C used in polydimethylsiloxane alcohols _11-13Isoparaffins, isohexadecane and polydimethylsiloxane provide particularly compact spray areas and strong deposition.

Example 3

Table 3 describes suitable concentration ranges for exemplary embodiments of the personal care compositions of the present invention. It has been found that the exemplary compositions of the present invention (with the formulations reported in table 3) provide a high average spray area (cm)²) The deposited concentrate and average spray droplet size (μm) provide unexpected improvements.

TABLE 3 Table 3

Composition of the components	Weight percent
		Volatile compounds	15-60
Emollient(s)	5-10
		Gum blends	5-10
Active substances	4-60
		Hectorite clay derivatives	1-25

While the present invention has been described with reference to several embodiments, which have been set forth in considerable detail in order to fully disclose the invention, such embodiments are merely illustrative and are not intended to limit or represent an exhaustive list of all aspects of the invention. The scope of the invention should be determined from the claims that follow. Furthermore, it will be apparent to those skilled in the art that numerous changes in the details may be made without departing from the spirit and principles of the invention.

Claims

1. A personal care composition comprising:

having (CH 3)₂CH(CH2)_7-9CH₃Volatile compounds of (a);

organic derivatives of hectorite clay; and

a silicone-containing gum blend comprising

Polydimethyl siloxane; and

polydimethyl siloxane alcohol.

2. The personal care composition of claim 1, wherein the volatile compound is isododecane.

3. The personal care composition of claim 1 or claim 2, wherein the volatile compound is present in the aerosol concentrate in an amount of from about 5 wt% to about 75 wt%, from 5 wt% to about 60 wt%, from 5 wt% to about 20 wt%, or from 40 wt% to about 65 wt%, or from about 0.75 wt% to about 11.25 wt%, from about 0.75 wt% to about 9.0 wt%, from about 0.75 wt% to about 3.0 wt% or from about 6.0 wt% to about 9.75 wt%, calculated in the presence of a propellant (15 wt% concentrate and 85 wt% propellant).

4. The personal care composition of any of the preceding claims, wherein the derivative of hectorite clay is selected from the group consisting of sela-ammonium hectorite, disteardimonium hectorite, and combinations thereof.

5. The personal care composition of any of the preceding claims, wherein the derivative of hectorite clay is present in the aerosol concentrate in an amount of from about 1 wt% to about 5 wt%, from about 1 wt% to about 4 wt%, or from about 2 wt% to about 5 wt%, or when calculated in the presence of a propellant (15 wt% concentrate and 85 wt% propellant), from about 0.15 wt% to about 0.75 wt%, from about 0.15 wt% to about 0.6 wt%, or from about 0.3 wt% to about 0.75 wt%.

6. The personal care composition of any of the preceding claims, wherein the viscosity of the silicon-containing gum blend is from about 6,000cp to about 16,000cp at 25 ℃.

7. The personal care composition of any of the preceding claims, wherein the silicon-containing gum blend is present in the aerosol concentrate in an amount of from about 2 wt% to about 15 wt%, from about 2 wt% to about 10 wt%, from about 2 wt% to about 8 wt%, or from about 6 wt% to about 10 wt%, or when calculated in the presence of a propellant (15 wt% concentrate and 85 wt% propellant), from about 0.3 wt% to about 2.25 wt%, from about 0.3 wt% to about 1.5 wt%, from about 0.3 wt% to about 1.2 wt%, or from about 0.9 wt% to about 1.5 wt%.

8. The personal care composition of any of the preceding claims, wherein the composition is substantially free of cyclomethicone, or free of cyclomethicone.

9. The personal care composition of any preceding claim, wherein the composition further comprises an emollient, wherein the emollient is optionally selected from isopropyl myristate, isopropyl palmitate, myristyl palmitate, polydimethylsiloxane, diheptyl succinate, and caprylyl glycerol/sebacic acid copolymers, and combinations thereof.

10. The personal care composition of claim 9, wherein the emollient is present in the aerosol concentrate in an amount of from about 2 wt.% to about 40 wt.%, from about 2 wt.% to about 25 wt.%, from about 2 wt.% to about 10 wt.%, from about 2 wt.% to about 8 wt.%, or from about 4 wt.% to about 8 wt.%, or from about 0.3 wt.% to about 6.0 wt.%, from about 0.3 wt.% to about 3.75 wt.%, from about 0.3 wt.% to about 1.5 wt.%, from about 0.3 wt.% to about 1.2 wt.%, or from about 0.6 wt.% to about 1.2 wt.% calculated in the presence of the propellant (15 wt.% concentrate and 85 wt.% propellant).

11. The personal care composition of any of the preceding claims, wherein the polydimethylsiloxane is present up to 16 wt.%.

12. The personal care composition of any of the preceding claims, wherein the composition is selected from the group consisting of deodorants, antiperspirants, and combinations of two or more thereof.

13. The personal care composition of any preceding claim, wherein the composition is an aerosol.

14. A method of treating, preventing or ameliorating a symptom associated with a disease, disorder or condition of keratinous material, comprising administering to a keratinous material in a subject in need thereof a personal care composition according to any preceding claim.

15. The method of claim 14, wherein the keratinous material is selected from the group consisting of: skin, hair, and combinations thereof.

16. A personal care composition comprising:

organic derivatives of hectorite clay; and

a silicone-containing gum blend comprising:

polydimethyl siloxane; and

polydimethyl siloxane alcohol;

wherein the polydimethylsiloxane is present up to 16% by weight of the composition.

17. The personal care composition of claim 16, wherein the derivative of hectorite clay is selected from the group consisting of sela-chloranite hectorite, disteardimonium hectorite, and combinations thereof.

18. The personal care composition of any one of claims 16 or 17, wherein the derivative of hectorite clay is present in the aerosol concentrate in an amount of from about 1 wt.% to about 5 wt.%, from about 1 wt.% to about 4 wt.%, or from about 2 wt.% to about 5 wt.%, or from about 0.15 wt.% to about 0.75 wt.%, from about 0.15 wt.% to about 0.6 wt.%, or from about 0.3 wt.% to about 0.75 wt.% when calculated in the presence of a propellant (15 wt.% concentrate and 85 wt.% propellant).

19. The personal care composition of any one of claims 16-18, wherein the viscosity of the silicone-containing gum blend is from about 6,000cp to about 16,000cp at 25 ℃.

20. The personal care composition of any one of claims 16 to 19, wherein the silicon-containing gum blend is present in the aerosol concentrate in an amount of about 2 wt% to about 15 wt%, about 2 wt% to about 10 wt%, or about 2 wt% to about 8 wt%, or the silicon-containing gum blend is present in an amount of about 0.3 wt% to about 2.25 wt%, about 0.3 wt% to about 1.5 wt%, or about 0.3 wt% to about 1.2 wt%, when calculated in the presence of a propellant (15 wt% concentrate and 85 wt% propellant).

21. The personal care composition of any one of claims 16 to 20, wherein the composition is substantially free of cyclomethicone, or free of cyclomethicone.

22. The personal care composition of any one of claims 16 to 21, wherein the composition further comprises an emollient, wherein the emollient is optionally selected from isopropyl myristate, isopropyl palmitate, myristyl palmitate, polydimethylsiloxane, diheptyl succinate, and caprylyl glycerol/sebacic acid copolymer, and combinations thereof.

23. The personal care composition of claim 22, wherein the emollient is present in the aerosol concentrate in an amount of from about 2 wt.% to about 40 wt.%, from about 2 wt.% to about 25 wt.%, from about 2 wt.% to about 10 wt.%, from about 2 wt.% to about 8 wt.%, or from about 4 wt.% to about 8 wt.%, or from about 0.3 wt.% to about 6.0 wt.%, from about 0.3 wt.% to about 3.75 wt.%, from about 0.3 wt.% to about 1.5 wt.%, from about 0.3 wt.% to about 1.2 wt.%, or from about 0.6 wt.% to about 1.2 wt.% calculated in the presence of the propellant (15 wt.% concentrate and 85 wt.% propellant).

24. The personal care composition of any one of claims 16 to 23, wherein the composition is selected from the group consisting of deodorants, antiperspirants, and combinations of two or more thereof.

25. The personal care composition of any one of claims 16 to 24, wherein the composition is an aerosol.

26. A method of treating, preventing or ameliorating a symptom associated with a disease, disorder or condition of keratinous material, comprising administering to a keratinous material in a subject in need thereof a personal care composition according to any one of claims 16-25.

27. The method of claim 26, wherein the keratinous substance is chosen from: skin, hair, and combinations thereof.

28. A personal care composition comprising:

having (CH 3)₂CH(CH2)_7-9CH₃Volatile compounds of (a); and

a silicone-containing gum blend comprising:

polydimethyl siloxane; and

polydimethyl siloxane alcohol.

29. The personal care composition of claim 28, wherein the volatile compound is isododecane.

30. The personal care composition of claim 28 or claim 29, wherein the volatile compound is present in the aerosol concentrate in an amount of from about 5 wt% to about 75 wt%, from 5 wt% to about 60 wt%, from 5 wt% to about 20 wt%, or from 40 wt% to about 65 wt%, or from about 0.75 wt% to about 11.25 wt%, from about 0.75 wt% to about 9.0 wt%, from about 0.75 wt% to about 3.0 wt% or from about 6.0 wt% to about 9.75 wt%, calculated in the presence of a propellant (15 wt% concentrate and 85 wt% propellant).

31. The personal care composition of any one of claims 28-30, wherein the viscosity of the silicone-containing gum blend is from about 6,000cp to about 16,000cp at 25 ℃.

32. The personal care composition of any one of claims 28 to 31, wherein the silicon-containing gum blend is present in the aerosol concentrate in an amount of about 2 wt% to about 15 wt%, about 2 wt% to about 10 wt%, or about 2 wt% to about 8 wt%, or the silicon-containing gum blend is present in an amount of about 0.3 wt% to about 2.25 wt%, about 0.3 wt% to about 1.5 wt%, or about 0.3 wt% to about 1.2 wt%, when calculated in the presence of a propellant (15 wt% concentrate and 85 wt% propellant).

33. The personal care composition of any one of claims 28 to 32, wherein the composition is substantially free of cyclomethicone, or free of cyclomethicone.

34. The personal care composition of any one of claims 28 to 33, wherein the composition further comprises an emollient, wherein the emollient is optionally selected from isopropyl myristate, isopropyl palmitate, myristyl palmitate, polydimethylsiloxane, diheptyl succinate, and caprylyl glycerol/sebacic acid copolymer, and combinations thereof.

35. The personal care composition of claim 34, wherein the emollient is present in the aerosol concentrate in an amount of from about 2 wt.% to about 40 wt.%, from about 2 wt.% to about 25 wt.%, from about 2 wt.% to about 10 wt.%, from about 2 wt.% to about 8 wt.%, or from about 4 wt.% to about 8 wt.%, or from about 0.3 wt.% to about 6.0 wt.%, from about 0.3 wt.% to about 3.75 wt.%, from about 0.3 wt.% to about 1.5 wt.%, from about 0.3 wt.% to about 1.2 wt.%, or from about 0.6 wt.% to about 1.2 wt.% calculated in the presence of the propellant (15 wt.% concentrate and 85 wt.% propellant).

36. The personal care composition of any one of claims 28 to 35, wherein the polydimethylsiloxane is present up to 16 wt.%.

37. The personal care composition of any one of claims 28 to 36, wherein the composition is selected from the group consisting of deodorants, antiperspirants, and combinations of two or more thereof.

38. The personal care composition of any one of claims 28 to 37, wherein the composition is an aerosol.

39. A method of treating, preventing or ameliorating a symptom associated with a disease, disorder or condition of keratinous material, comprising administering to a keratinous material in a subject in need thereof a personal care composition according to any one of claims 28-38.

40. The method according to claim 39, wherein the keratinous material is chosen from: skin, hair, and combinations thereof.