CN115970491A - Ultrafiltration system - Google Patents

Abstract

The present disclosure relates to an ultrafiltration system comprising: a raw material tank configured to store a raw material solution of a biological product; a substitution liquid tank configured to store a substitution liquid; a cleaning liquid tank configured to store a cleaning liquid; an ultrafiltration membrane package configured to filter the feedstock solution; a switching device, connected to the raw material liquid tank, the displacement liquid tank and the cleaning liquid tank, in fluid communication with the ultrafiltration membrane module, and configured to selectively switch or close the fluid communication relationship among the raw material liquid tank, the displacement liquid tank, the cleaning liquid tank and the ultrafiltration membrane module; and the fluid driving unit is arranged on a flow path between the ultrafiltration membrane package and the switching device in series. Through this ultrafiltration system, can realize the automatic switch-over of different solutions, minimize manual operation reduces the cost of labor.

Description

Ultrafiltration system

Technical Field

The present disclosure relates to the field of bioengineering, and in particular, to an ultrafiltration system.

Background

In the process of preparing a biological product, it is often necessary to concentrate, purify, dialyze, replace, etc. the biological product. The traditional liquid dead-end filtration is most of microporous filtration, the flowing direction of the liquid is consistent with the filtering direction, the thickness of a filter cake layer or a gel layer formed on the surface of a filtering membrane is gradually increased along with the filtering, and the flow rate is gradually reduced. And tangential flow is a form of filtration where the direction of liquid flow is perpendicular to the direction of filtration.

Disclosure of Invention

The inventor researches and finds that the tangential flow ultrafiltration process of the related art needs to frequently replace corresponding solution joints according to different solutions required in the ultrafiltration step, and the labor cost is high.

In view of this, the disclosed embodiments provide an ultrafiltration system that minimizes manual operations.

In one aspect of the present disclosure, there is provided an ultrafiltration system comprising:

a raw material tank configured to store a raw material solution of a biological product;

a substitution liquid tank configured to store a substitution liquid;

a cleaning liquid tank configured to store a cleaning liquid;

an ultrafiltration membrane package configured to filter the feedstock solution;

a switching device, connected to the raw material liquid tank, the displacement liquid tank and the cleaning liquid tank, in fluid communication with the ultrafiltration membrane module, and configured to selectively switch or close the fluid communication relationship among the raw material liquid tank, the displacement liquid tank, the cleaning liquid tank and the ultrafiltration membrane module;

and the fluid driving unit is arranged on a flow path between the ultrafiltration membrane package and the switching device in series.

In some embodiments, wherein the switching means comprises:

the switching valve is provided with a plurality of connecting pipe openings and a fluid outlet, and the plurality of connecting pipe openings are respectively communicated with the raw material liquid tank, the displacement liquid tank and the cleaning liquid tank through pipelines;

the liquid collecting tank is communicated with the fluid outlet of the switching valve through a pipeline and is respectively communicated with the fluid driving unit and the ultrafiltration membrane package through pipelines;

and the controller is in signal connection with the switching valve and the fluid driving unit and is configured to control the switching and opening and closing of the switching valve and control the opening and closing of the fluid driving unit.

In some embodiments, the ultrafiltration system comprises:

the controller is in signal connection with the first liquid level sensor, and is configured to enable the switching valve to be switched to a state that the raw material liquid tank is communicated with the liquid collecting tank and start the fluid driving unit when receiving a first preset liquid level signal sent by the first liquid level sensor.

In some embodiments, the ultrafiltration system comprises:

a waste liquid tank in communication with the waste liquid outlet of the ultrafiltration membrane package, configured to collect waste liquid flowing out of the ultrafiltration membrane package;

the controller is in signal connection with the second liquid level sensor, and is configured to stop the operation of the fluid driving unit when receiving a second preset liquid level signal sent by the second liquid level sensor, and to continue the operation of the fluid driving unit when receiving a no liquid level signal sent by the second liquid level sensor.

In some embodiments, the ultrafiltration system comprises:

a third liquid level sensor positioned in the displacement liquid tank and configured to detect the liquid level of the displacement liquid tank;

a product liquid tank in communication with the product liquid outlet of the liquid tank configured to collect product liquid flowing out of the liquid tank;

the liquid discharge electromagnetic valve is arranged on a flow path between a finished product liquid outlet of the liquid collecting tank and the finished product liquid tank in series;

the controller is in signal connection with the first liquid level sensor, the third liquid level sensor and the liquid discharge electromagnetic valve, and is configured to enable the switching valve to be switched to a state that the replacement liquid tank and the liquid collection tank are communicated when a no-liquid-level signal sent by the first liquid level sensor is received, start the fluid driving unit, and enable the fluid driving unit to continue to operate for a first preset time and then open the liquid discharge electromagnetic valve when a no-liquid-level signal sent by the third liquid level sensor is received.

In some embodiments, the ultrafiltration system comprises:

and the controller is in signal connection with the fourth liquid level sensor, is configured to close the liquid discharge electromagnetic valve after being opened for a second preset time, then switches the switching valve to a state that the cleaning liquid tank is communicated with the liquid collecting tank, starts the fluid driving unit, and closes the fluid driving unit after running for a third preset time when receiving a no-liquid-level signal sent by the fourth liquid level sensor.

In some embodiments, the ultrafiltration system comprises:

a waste liquid tank in communication with the waste liquid outlet of the ultrafiltration membrane module, configured to collect waste liquid flowing out of the ultrafiltration membrane module;

the waste liquid electromagnetic valve is arranged on a flow path between the outlet of the ultrafiltration membrane package and the waste liquid groove in series;

and the controller is in signal connection with the waste liquid solenoid valve and the fourth liquid level sensor and is configured to close the waste liquid solenoid valve when receiving a no-liquid-level signal sent by the fourth liquid level sensor.

In some embodiments, the ultrafiltration system comprises:

and the one-way stop valve is serially arranged on a flow path between the ultrafiltration membrane package and the liquid collecting tank and is communicated from the liquid collecting tank to the ultrafiltration membrane package in a one-way mode.

In some embodiments, the ultrafiltration system comprises:

and the refrigerating assembly is positioned at the bottom of at least one of the raw material liquid tank, the displacement liquid tank and the cleaning liquid tank.

In some embodiments, the ultrafiltration system comprises:

and the touch screen is in signal connection with the controller.

In some embodiments, the ultrafiltration system comprises:

a housing, wherein the ultrafiltration membrane module, the fluid drive unit, the sump, the switching valve, and the controller are all disposed within the housing.

In some embodiments, the ultrafiltration system comprises:

and the controller, the raw material liquid tank, the replacement liquid tank and the cleaning liquid tank are fixedly arranged above the placing plate, and the liquid collecting tank, the ultrafiltration membrane module and the fluid driving unit are arranged below the placing plate.

In some embodiments, the ultrafiltration system comprises:

the partition plate is positioned below the placing plate;

and the refrigerating assembly is positioned at the bottom of at least one of the raw material liquid tank, the displacement liquid tank and the cleaning liquid tank and is positioned between the placing plate and the partition plate.

Therefore, according to the embodiment of the disclosure, the ultrafiltration system can automatically complete the alternative switching or closing of the communication relationship between different solution tanks and the ultrafiltration membrane package through the switching device without frequently switching the solution interfaces by a user, thereby reducing the manual operation as much as possible and reducing the labor cost.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the disclosure and together with the description, serve to explain the principles of the disclosure.

The present disclosure may be more clearly understood from the following detailed description, taken with reference to the accompanying drawings, in which:

FIG. 1 is a schematic diagram of the overall architecture of an ultrafiltration system according to some embodiments of the present disclosure;

FIG. 2 is a schematic view of an ultrafiltration system from a top view according to some embodiments of the present disclosure;

fig. 3 (a) and (b) are schematic diagrams of the internal structure of an ultrafiltration system according to some embodiments of the present disclosure, respectively, at different viewing angles.

It should be understood that the dimensions of the various parts shown in the figures are not drawn to scale. Further, the same or similar reference numerals denote the same or similar components.

Detailed Description

Various exemplary embodiments of the present disclosure will now be described in detail with reference to the accompanying drawings. The description of the exemplary embodiments is merely illustrative and is in no way intended to limit the disclosure, its application, or uses. The present disclosure may be embodied in many different forms and is not limited to the embodiments described herein. These embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art. It should be noted that: the relative arrangement of parts and steps, the composition of materials, numerical expressions and numerical values set forth in these embodiments are to be construed as merely illustrative, and not restrictive, unless specifically stated otherwise.

The use of "first," "second," and similar terms in this disclosure is not intended to indicate any order, quantity, or importance, but rather are used to distinguish one element from another. The word "comprising" or "comprises", and the like, means that the element preceding the word covers the element listed after the word, and does not exclude the possibility that other elements are also covered. "upper", "lower", "left", "right", and the like are used only to indicate relative positional relationships, and when the absolute position of the object to be described is changed, the relative positional relationships may also be changed by a preset.

In the present disclosure, when a specific device is described as being located between a first device and a second device, there may or may not be intervening devices between the specific device and the first device or the second device. When a particular device is described as being coupled to other devices, that particular device may be directly coupled to the other devices without intervening devices or may be directly coupled to the other devices with intervening devices.

All terms (including technical or scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs unless specifically defined otherwise. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.

Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate.

Fig. 1 is a schematic diagram of the overall architecture of an ultrafiltration system according to some embodiments of the present disclosure. Referring to fig. 1, in some embodiments, an ultrafiltration system comprises: a raw material liquid tank 1, a displacement liquid tank 2, a cleaning liquid tank 3, an ultrafiltration membrane package 4, a switching device and a fluid driving unit 5.

The raw material liquid tank 1 is configured to store raw material solution of biological products, the substitution liquid tank 2 is configured to store substitution liquid required in an ultrafiltration process, the cleaning liquid tank 3 is configured to store cleaning liquid, and the ultrafiltration membrane module 4 is configured to filter the raw material solution.

The switching device is connected with the raw material liquid tank 1, the displacement liquid tank 2 and the cleaning liquid tank 3, is communicated with the ultrafiltration membrane package 4 in a fluid mode, and is configured to switch or close the fluid communication relation among the raw material liquid tank 1, the displacement liquid tank 2, the cleaning liquid tank 3 and the ultrafiltration membrane package 4 alternatively.

The fluid driving unit 5 is arranged in series on the flow path between the ultrafiltration membrane package 4 and the switching device, and can drive the solution required in the ultrafiltration process into the ultrafiltration membrane package 4.

When the ultrafiltration process starts, the raw material liquid, the displacement liquid and the cleaning liquid are respectively filled into the corresponding raw material liquid tank 1, the displacement liquid tank 2 and the cleaning liquid tank 3, the circulation state between the required solution and the ultrafiltration membrane package 4 in the ultrafiltration process is selected through the switching device, and the fluid driving unit 5 controls the required solution to flow into the ultrafiltration membrane package 4 for corresponding operation.

Compared with the prior art, the ultrafiltration membrane package 4 and different solution tanks need to be manually connected through pipelines when different solutions are selected, a large amount of manpower is consumed by frequent operation, the switching device can be used for completing the switching or closing of the flow relations among the raw material liquid tank 1, the displacement liquid tank 2, the cleaning liquid tank 3 and the ultrafiltration membrane package 4, the manual operation is reduced as much as possible, and the labor cost is saved.

Fig. 2 is a schematic view of an ultrafiltration system from a top view perspective, according to some embodiments of the present disclosure. Fig. 3 (a) and (b) are schematic diagrams of the internal structure of an ultrafiltration system according to some embodiments of the present disclosure, respectively, at different viewing angles. Referring to fig. 1, 2 and 3 (a), in some embodiments, the switching device includes: a switching valve 6, a sump 7 and a controller 8. The switching valve 6 has a plurality of connecting ports 23 and fluid outlets, and the plurality of connecting ports 23 are respectively communicated with the raw material liquid tank 1, the displacement liquid tank 2 and the cleaning liquid tank 3 through pipelines. The liquid collecting tank 7 is communicated with the fluid outlet of the switching valve 6 through a pipeline, and is respectively communicated with the fluid driving unit 5 and the ultrafiltration membrane package 4 through pipelines. The controller 8 is in signal connection with the switching valve 6 and the fluid driving unit 5, and is configured to control the switching and opening and closing of the switching valve 6, and control the opening and closing of the fluid driving unit 5.

The controller 8 connects the connection pipe 23 of the switching valve 6 with a solution tank required in the ultrafiltration process, and causes the fluid driving unit 5 to drive the required solution to flow into the ultrafiltration membrane module 4 through the liquid collecting tank 7 for ultrafiltration.

Referring to fig. 1 and 2, in some embodiments, an ultrafiltration system comprises: a first level sensor 9. The first liquid level sensor 9 is located in the raw material liquid tank 1 and configured to detect the liquid level of the raw material liquid tank 1, wherein the controller 8 is in signal connection with the first liquid level sensor 9 and configured to switch the switching valve 6 to a state where the raw material liquid tank 1 is communicated with the liquid collecting tank 7 and start the fluid driving unit 5 when receiving a first preset liquid level signal sent by the first liquid level sensor 9.

Compared with the situation that the liquid level in the raw material liquid tank 1 needs to be monitored manually in the related art, the liquid level signal of the raw material liquid tank 1 is monitored in real time by the first liquid level sensor 9 in the embodiment, and the signal is sent to the controller 8. The user can set up first preset liquid level according to the required raw materials liquid volume value of ultrafiltration process, and when the liquid level in raw materials cistern 1 reached first preset liquid level, controller 8 just made diverter valve 6 switch to the state that raw materials cistern 1 and collecting tank 7 communicate, and the drive unit drive raw materials liquid in raw materials cistern 1 gets into ultrafiltration membrane package 4 and begins the ultrafiltration. The ultrafiltration process can be started without manual operation.

Referring to fig. 1, in some embodiments, an ultrafiltration system comprises: a waste liquid tank 10 and a second liquid level sensor 11. The waste liquid tank 10 is communicated with the waste liquid outlet of the ultrafiltration membrane module 4, and is configured to collect waste liquid flowing out of the ultrafiltration membrane module 4. A second liquid level sensor 11 is located in the waste liquid tank 10 and configured to detect the liquid level in the waste liquid tank 10, wherein the controller 8 is in signal connection with the second liquid level sensor 11 and configured to stop the operation of the fluid driving unit 5 when receiving a second preset liquid level signal sent by the second liquid level sensor 11 and to continue the operation of the fluid driving unit 5 when receiving a no liquid level signal sent by the second liquid level sensor 11.

Compared with the start and stop of the ultrafiltration process which needs to be manually controlled in the related art, the user can set a second preset liquid level according to the capacity of the waste liquid tank 10 in the embodiment, when the liquid level of the waste liquid tank 10 reaches the second preset liquid level, the ultrafiltration process is suspended by the controller 8, the waste liquid in the waste liquid tank 10 can be discharged at the moment, and the ultrafiltration process is recovered by the controller 8 when the waste liquid tank 10 is emptied.

Referring to fig. 1, fig. 2, and fig. 3 (b), in some embodiments, an ultrafiltration system comprises: a third liquid level sensor 12, a finished product liquid tank 13, a liquid discharge electromagnetic valve 14 and a first liquid level sensor 9. A third liquid level sensor 12 is located within the displacement fluid tank 2 and is configured to detect the liquid level of the displacement fluid tank 2. The product liquid tank 13 communicates with a product liquid outlet of the liquid tank 7 and is configured to collect the product liquid flowing out of the liquid tank 7. The liquid discharge solenoid valve 14 is arranged in series on a flow path between the product liquid outlet of the liquid collecting tank 7 and the product liquid tank 13. A first level sensor 9 is located within the raw material tank 1 and is configured to detect a level of the raw material tank 1.

The controller 8 is in signal connection with the first liquid level sensor 9, the third liquid level sensor 12 and the liquid discharge solenoid valve 14, and is configured to, when receiving a no-liquid-level signal sent by the first liquid level sensor 9, switch the switching valve 6 to a state in which the replacement liquid tank 2 and the liquid collection tank 7 are communicated, start the fluid driving unit 5, and, when receiving a no-liquid-level signal sent by the third liquid level sensor 12, cause the fluid driving unit 5 to continue to operate for a first preset time period and then open the liquid discharge solenoid valve 14.

Compared with the prior art in which the pipeline connection needs to be replaced manually to complete the switching of different solutions required in the ultrafiltration process, in this embodiment, after the first liquid level sensor 9 detects that all the raw material liquid in the raw material liquid tank 1 enters the ultrafiltration membrane module 4, the membrane module is automatically switched to be connected with the replacement liquid tank, and the replacement process is started. The user can set a third preset liquid level according to the volume of the replacement liquid, and set a first preset duration according to the duration of continuous driving of the driving unit required after the replacement is completed. When the third liquid level sensor 12 detects that all the replacement liquid in the replacement liquid tank 2 enters the ultrafiltration membrane package 4, the driving unit continues to operate for a first preset time, and the liquid discharge electromagnetic valve 14 discharges the finished product liquid in the liquid collection tank 7.

Referring to fig. 2, in some embodiments, an ultrafiltration system comprises: a fourth level sensor 15. A fourth liquid level sensor 15 is located in the cleaning liquid tank 3 and configured to detect the liquid level of the cleaning liquid tank 3, wherein the controller 8 is in signal connection with the fourth liquid level sensor 15 and configured to close the liquid discharge solenoid valve 14 after being opened for a second preset time period, then switch the switching valve 6 to a state where the cleaning liquid tank 3 is communicated with the liquid collection tank 7, start the fluid driving unit 5, and close the fluid driving unit 5 after running for a third preset time period when receiving a no-liquid-level signal sent by the fourth liquid level sensor 15.

Compared with the prior art in which the pipeline connection needs to be replaced manually to complete the switching of different solutions required in the ultrafiltration process, in this embodiment, the user can set the second preset time period according to the liquid discharge time period of the liquid discharge electromagnetic valve 14, and set the third preset time period according to the time period required for the driving unit to continue driving after the cleaning is completed. In the embodiment, after the fourth liquid level sensor 15 detects that all the cleaning liquid in the cleaning liquid tank 3 enters the ultrafiltration membrane package 4, the driving unit continues to operate for a third preset time period and then stops operating.

Referring to fig. 1 and fig. 3 (b), in some embodiments, an ultrafiltration system comprises: a waste liquid tank 10, a waste liquid solenoid valve 16, and a fourth level sensor 15. A waste liquid tank 10 is in communication with the waste liquid outlet of the ultrafiltration membrane module 4 and is configured to collect waste liquid flowing out of the ultrafiltration membrane module 4. A waste liquid electromagnetic valve 16 is arranged in series on a flow path between the outlet of the ultrafiltration membrane package 4 and the waste liquid groove 10.

A fourth liquid level sensor 15 is located in the cleaning liquid tank 3 and configured to detect the liquid level of the cleaning liquid tank 3, wherein the controller 8 is in signal connection with the waste liquid solenoid valve 16 and the fourth liquid level sensor 15 and configured to close the waste liquid solenoid valve 16 when receiving a no liquid level signal sent by the fourth liquid level sensor 15.

Compared with the prior art in which the pipeline connection needs to be replaced manually to complete the switching of different solutions required in the ultrafiltration process, the fourth liquid level sensor 15 in the embodiment detects that all the cleaning liquid in the cleaning liquid tank 3 enters the ultrafiltration membrane package 4, and then the waste liquid discharge is stopped.

Referring to fig. 3 (a), in some embodiments, an ultrafiltration system comprises: a one-way shut-off valve 17. The one-way stop valve 17 is arranged in series on a flow path between the ultrafiltration membrane package 4 and the liquid collecting tank 7, and is in one-way conduction from the liquid collecting tank 7 to the ultrafiltration membrane package 4. After cleaning, the ultrafiltration membrane module 4 is filled with a cleaning solution, and the one-way cutoff valve 17 prevents the reverse flow of the cleaning solution.

Referring to fig. 1, in some embodiments, an ultrafiltration system comprises: a refrigeration assembly 18. The refrigerating assembly 18 is positioned at the bottom of at least one of the raw material liquid tank 1, the displacement liquid tank 2 and the cleaning liquid tank 3.

Compared with the prior art that the solution needing low-temperature preservation lacks preservation conditions, the solution is kept at a certain temperature by continuously refrigerating through the refrigerating component 18.

Referring to fig. 2, in some embodiments, an ultrafiltration system comprises: a touch screen 19. The touch screen 19 is in signal connection with the controller 8. The user can operate the controller 8 to complete different commands through the touch screen 19.

Referring to fig. 1, in some embodiments, an ultrafiltration system comprises: a housing 20. A housing 20, the ultrafiltration membrane module 4, the fluid drive unit 5, the sump 7, the switching valve 6 and the controller 8 are all disposed within the housing 20. This embodiment integrates the ultrafiltration membrane module 4, the fluid drive unit 5, the sump 7, the switching valve 6 and the controller 8 such that the piping is hidden in the housing 20 to avoid entanglement.

Referring to fig. 1, in some embodiments, an ultrafiltration system comprises: the board 21 is placed. A placing plate 21 is arranged in the housing 20, the controller 8, the raw material liquid tank 1, the replacement liquid tank 2 and the cleaning liquid tank 3 are all fixedly arranged above the placing plate 21, and the liquid collecting tank 7, the ultrafiltration membrane module 4 and the fluid driving unit 5 are all arranged below the placing plate 21.

Referring to fig. 1, in some embodiments, an ultrafiltration system comprises: a partition 22 and a refrigeration assembly 18. A partition 22 is located below the placement plate 21 to separate the refrigeration unit 18 from the raw material liquid tank. The refrigerating assembly 18 is located at the bottom of at least one of the raw material tank 1, the displacement tank 2 and the cleaning tank 3, and is located between the placing plate 21 and the partition plate 22.

In some embodiments, the fluid drive unit 5 in the ultrafiltration system is a peristaltic pump.

In some embodiments, the refrigeration assembly 18 in the ultrafiltration system is a semiconductor refrigerator. The semiconductor assembly operates to maintain the solution at a temperature, which may be selected to be 0 to 8 ℃. And, the semiconductor cooler is small in size, so that the ultrafiltration system is more compact. In other embodiments, the refrigeration assembly may also take other configurations, such as heat exchangers, etc.

The operation of an example of the ultrafiltration system of the present disclosure is described below with reference to the foregoing embodiments and (b) of fig. 1-3.

Before the ultrafiltration starts, the raw material solution is filled into a raw material liquid tank 1, the replacement liquid is filled into a replacement liquid tank 2 and the cleaning liquid is filled into a cleaning liquid tank 3, and each pipeline is connected to a corresponding solution pipe connecting port. When the click starts on the touch screen 19, the ultrafiltration system starts to operate.

When the controller 8 receives a first preset liquid level signal sent by the first liquid level sensor 9, the fluid driving unit 5 drives the raw material solution to enter the ultrafiltration membrane package 4 through the liquid collecting tank 7, the inactivated virus solution is filtered, and the waste liquid flows into the waste liquid tank 10 through a waste liquid outlet of the ultrafiltration membrane package 4. When the controller 8 receives a second preset liquid level signal from the second liquid level sensor 11, the fluid driving unit 5 stops operating until the waste liquid in the waste liquid tank 10 is emptied. The effective solution in the ultrafiltration membrane package 4 will return to the liquid collecting tank 7 again until the first liquid level sensor 9 sends out no liquid level signal, then the switching valve 6 switches the liquid collecting tank 7 to the state communicated with the displacement liquid tank 2, and the fluid driving unit 5 drives the displacement liquid to enter the ultrafiltration membrane package 4 through the liquid collecting tank 7 for displacement. When the controller 8 receives a no-liquid-level signal sent by the third liquid level sensor 12, the liquid discharge electromagnetic valve 14 is opened after the fluid driving unit 5 continues to work for a first preset time period, and the finished product liquid is discharged into the finished product liquid tank 13. After the liquid discharge electromagnetic valve 14 discharges for a second preset time, the controller 8 closes the liquid discharge electromagnetic valve 14, and switches the switching valve 6 to a state that the liquid collecting tank 7 is communicated with the cleaning liquid tank 3, so as to clean the pipeline. When the fourth liquid level sensor 15 sends a no-liquid-level signal, the fluid driving unit 5 continues to operate for a third preset time period and then stops operating, and the waste liquid solenoid valve 16 is closed.

The cleaning solution is stored in the pipeline and the ultrafiltration membrane package 4, and the refrigeration component 18 continuously refrigerates the raw material liquid tank 1, the displacement liquid tank 2 and the cleaning solution tank 3 so as to keep the temperature of each solution at a preset temperature.

Thus, various embodiments of the present disclosure have been described in detail. Some details that are well known in the art have not been described in order to avoid obscuring the concepts of the present disclosure. Those skilled in the art can now fully appreciate how to implement the teachings disclosed herein, in view of the foregoing description.

Although some specific embodiments of the present disclosure have been described in detail by way of example, it should be understood by those skilled in the art that the above examples are for illustration only and are not intended to limit the scope of the present disclosure. It will be understood by those skilled in the art that various changes may be made in the above embodiments or equivalents may be substituted for elements thereof without departing from the scope and spirit of the present disclosure. The scope of the present disclosure is defined by the appended claims.

Claims (15)

1. An ultrafiltration system, comprising:

a raw material tank (1) configured to store a raw material solution of a biological product;

a replacement liquid tank (2) configured to store a replacement liquid;

a cleaning liquid tank (3) configured to store a cleaning liquid;

an ultrafiltration membrane package (4) configured to filter the raw material solution;

the switching device is connected with the raw material liquid tank (1), the displacement liquid tank (2) and the cleaning liquid tank (3), is communicated with the ultrafiltration membrane package (4) in a fluid mode, and is configured to switch or close the fluid communication relation among the raw material liquid tank (1), the displacement liquid tank (2), the cleaning liquid tank (3) and the ultrafiltration membrane package (4) in an alternative mode;

a fluid driving unit (5) arranged in series on the flow path between the ultrafiltration membrane package (4) and the switching device.

2. The ultrafiltration system of claim 1, wherein the switching device comprises:

the switching valve (6) is provided with a plurality of connecting pipe openings (23) and fluid outlets, and the plurality of connecting pipe openings (23) are respectively communicated with the raw material liquid tank (1), the displacement liquid tank (2) and the cleaning liquid tank (3) through pipelines;

a liquid collecting tank (7) which is communicated with a fluid outlet of the switching valve (6) through a pipeline and is respectively communicated with the fluid driving unit (5) and the ultrafiltration membrane package (4) through pipelines;

and the controller (8) is in signal connection with the switching valve (6) and the fluid driving unit (5) and is configured to control the switching, opening and closing of the switching valve (6) and control the opening and closing of the fluid driving unit (5).

3. The ultrafiltration system of claim 2, further comprising:

a first liquid level sensor (9) located within the raw material tank (1) and configured to detect a liquid level of the raw material tank (1),

the controller (8) is in signal connection with the first liquid level sensor (9), and is configured to enable the switching valve (6) to be switched to a state that the raw material liquid tank (1) is communicated with the liquid collecting tank (7) and start the fluid driving unit (5) when receiving a first preset liquid level signal sent by the first liquid level sensor (9).

4. The ultrafiltration system of claim 2, further comprising:

a waste liquid tank (10) communicated with the waste liquid outlet of the ultrafiltration membrane package (4) and configured to collect waste liquid flowing out of the ultrafiltration membrane package (4);

a second liquid level sensor (11) located in the waste liquid tank (10) and configured to detect a liquid level in the waste liquid tank (10),

wherein the controller (8) is in signal connection with the second liquid level sensor (11) and is configured to stop the operation of the fluid driving unit (5) when receiving a second preset liquid level signal sent by the second liquid level sensor (11) and to continue the operation of the fluid driving unit (5) when receiving a no liquid level signal sent by the second liquid level sensor (11).

5. The ultrafiltration system of claim 2, further comprising:

a third liquid level sensor (12) located within the displacement fluid tank (2) and configured to detect a liquid level of the displacement fluid tank (2);

a product liquid tank (13) in communication with a product liquid outlet of the liquid collection tank (7) configured to collect product liquid flowing out of the liquid collection tank (7);

the liquid discharge electromagnetic valve (14) is arranged on a flow path between a finished product liquid outlet of the liquid collecting tank (7) and the finished product liquid tank (13) in series;

a first liquid level sensor (9) located within the raw material tank (1) configured to detect a liquid level of the raw material tank (1),

the controller (8) is in signal connection with the first liquid level sensor (9), the third liquid level sensor (12) and the liquid discharge electromagnetic valve (14), and is configured to enable the switching valve (6) to be switched to a state that the displacement liquid tank (2) and the liquid collecting tank (7) are communicated when a no-liquid-level signal sent by the first liquid level sensor (9) is received, start the fluid driving unit (5), and enable the fluid driving unit (5) to continuously operate for a first preset time and then open the liquid discharge electromagnetic valve (14) when a no-liquid-level signal sent by the third liquid level sensor (12) is received.

6. The ultrafiltration system of claim 5, further comprising:

a fourth liquid level sensor (15) located within the cleaning liquid tank (3) configured to detect a liquid level of the cleaning liquid tank (3),

the controller (8) is in signal connection with the fourth liquid level sensor (15), and is configured to close the liquid discharge electromagnetic valve (14) after being opened for a second preset time period, then switch the switching valve (6) to a state that the cleaning liquid tank (3) is communicated with the liquid collecting tank (7), start the fluid driving unit (5), and close the fluid driving unit (5) after running for a third preset time period when receiving a no-liquid-level signal sent by the fourth liquid level sensor (15).

7. The ultrafiltration system of claim 2, further comprising:

a waste liquid tank (10) communicated with the waste liquid outlet of the ultrafiltration membrane package (4) and configured to collect waste liquid flowing out of the ultrafiltration membrane package (4);

a waste liquid electromagnetic valve (16) which is arranged on a flow path between the outlet of the ultrafiltration membrane package (4) and the waste liquid groove (10) in series;

a fourth liquid level sensor (15) located within the cleaning liquid tank (3) configured to detect a liquid level of the cleaning liquid tank (3),

wherein the controller (8) is in signal connection with the waste liquid solenoid valve (16) and the fourth liquid level sensor (15) and is configured to close the waste liquid solenoid valve (16) when receiving a no liquid level signal from the fourth liquid level sensor (15).

8. The ultrafiltration system of any one of claims 2 to 7, further comprising:

and the one-way stop valve (17) is arranged on a flow path between the ultrafiltration membrane package (4) and the liquid collecting tank (7) in series and is communicated with the ultrafiltration membrane package (4) from the liquid collecting tank (7) in a one-way mode.

9. The ultrafiltration system of any one of claims 1 to 7, further comprising:

and the refrigerating component (18) is positioned at the bottom of at least one of the raw material liquid tank (1), the replacement liquid tank (2) and the cleaning liquid tank (3).

10. The ultrafiltration system of any one of claims 2 to 7, further comprising:

and the touch screen (19) is in signal connection with the controller (8).

11. The ultrafiltration system of any one of claims 2 to 7, further comprising:

a housing (20), wherein the ultrafiltration membrane package (4), the fluid drive unit (5), the sump (7), the switching valve (6) and the controller (8) are all disposed within the housing.

12. The ultrafiltration system of claim 11, further comprising:

a placement plate (21) disposed within the housing,

the controller (8), the raw material liquid tank (1), the replacement liquid tank (2) and the cleaning liquid tank (3) are all fixedly arranged above the placing plate, and the liquid collecting tank (7), the ultrafiltration membrane module (4) and the fluid driving unit (5) are all arranged below the placing plate.

13. The ultrafiltration system of claim 12, further comprising:

a partition (22) located below the placement plate;

and the refrigerating assembly (18) is positioned at the bottom of at least one of the raw material liquid tank (1), the replacement liquid tank (2) and the cleaning liquid tank (3), and is positioned between the placing plate and the partition plate.

14. The ultrafiltration system according to any one of claims 1 to 7, wherein the fluid drive unit (5) is a peristaltic pump.

15. The ultrafiltration system of claim 9, wherein the refrigeration assembly is a semiconductor refrigerator.

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