CN115969821A - Medical oral paraffin oil composition for improving mouthfeel and application thereof - Google Patents
Medical oral paraffin oil composition for improving mouthfeel and application thereof Download PDFInfo
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- CN115969821A CN115969821A CN202310005497.5A CN202310005497A CN115969821A CN 115969821 A CN115969821 A CN 115969821A CN 202310005497 A CN202310005497 A CN 202310005497A CN 115969821 A CN115969821 A CN 115969821A
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- paraffin oil
- medical oral
- oil composition
- flavoring agent
- oral
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a medical oral paraffin oil composition for improving mouthfeel and application thereof, wherein the medical oral paraffin oil composition comprises medical oral paraffin oil and a flavoring agent, and the adding mass of the flavoring agent accounts for 0.5-10% of the total mass of the medical oral paraffin oil composition, or the adding volume of the flavoring agent accounts for 0.5-10% of the total volume of the medical oral paraffin oil composition. The correctant is selected from sweetener, or mixture of sweetener and aromatic, and is added into medical oral paraffin oil via correctant, dissolved, mixed well, and bottled to obtain the final product. The taste of the medical oral paraffin oil can be obviously improved by adding the flavoring agent, the medicine for treating the incomplete intestinal obstruction meets the requirements of special groups on the flavoring agent, the compliance of patients is improved, the application is wide, the operation is simple, the method is suitable for industrial production, and the market prospect is wide.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a medical oral paraffin oil composition for improving mouthfeel and application thereof.
Background
Intestinal obstruction is a common clinical disease, and medical oral paraffin oil is an important medicament for treating incomplete intestinal obstruction. The paraffin oil can relieve intestinal obstruction and restore intestinal canal smoothness by oral administration, and is an important medicament for conservative treatment of intestinal obstruction. However, poor taste is the main defect of medical paraffin oil, which affects the compliance of patients, especially children and old patients. The flavoring agent is added into the medical paraffin oil, so that the taste of the paraffin oil is improved, the pharmacological effect of the paraffin oil on relaxing bowel is kept, and the paraffin oil has the advantages of simple technology, low economic cost and obvious effect. At present, a plurality of medicines on the market and in research achieve the purpose of improving the mouthfeel by adding a flavoring agent, but no related report on improving the mouthfeel of medical oral paraffin oil by adding the flavoring agent is available.
Disclosure of Invention
In order to solve the problem of poor patient compliance caused by poor taste of the oral paraffin oil in the prior art, the invention aims to provide the medical oral paraffin oil composition with improved taste, and the medical oral paraffin oil composition is obtained by adding a flavoring agent, so that the taste is improved, and the patient compliance in taking medicine is improved.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a medical oral paraffin oil composition for improving mouthfeel, which comprises medical oral paraffin oil and a flavoring agent, wherein the adding mass of the flavoring agent accounts for 0.5-10% of the total mass of the medical oral paraffin oil composition, or the adding volume of the flavoring agent accounts for 0.5-10% of the total volume of the medical oral paraffin oil composition.
Preferably, the flavoring agent is a flavoring agent which disturbs the taste perception of medical oral paraffin oil by self taste and smell to human body taste and smell organs, and comprises a sweetening agent or a mixture of the sweetening agent and a flavoring agent, wherein:
the sweetener is selected from one or more of saccharin sodium, sucralose, aspartame, neotame and acesulfame potassium;
the aromatic is selected from one or more of herba Menthae type essence, fructus Citri Limoniae type essence, fructus Jujubae type essence, fructus Fortunellae margaritae type essence, flos Osmanthi Fragrantis type essence, cortex Cinnamomi type essence, vanillin, geraniol and citral.
The two flavoring agents are medicinal adjuvants and food additives with good solubility in medical paraffin oil, and can be mixed for use, wherein the sweetening agent has the main function of flavoring, and can be used alone or mixed with aromatic.
Preferably, the sweetening agent with high sweetness intensity is used alone to improve the mouthfeel of the medical paraffin oil, 2 or more than 2 sweetening agents are used simultaneously to effectively increase the sweetness of the medical oral paraffin oil, and the use of the aromatic agent can increase the fragrance of the liquid and play an auxiliary role in improving the taste.
The invention also provides a preparation method of the medical oral paraffin oil composition for improving mouthfeel, which comprises the following steps: adding the correctant into the medical oral paraffin oil, dissolving, mixing, and bottling.
Preferably, the flavoring agent is dissolved in the medical oral paraffin oil, and the dissolving and mixing method comprises ultrasonic, shaking and stirring.
Preferably, the sweetener and the aromatic are added into the same category, and the sweetener and the aromatic are not added sequentially and can be added simultaneously; when the sweetening agent and the aromatic are used at the same time, the sweetening agent is added firstly, and the adding process flow comprises mixing and standing; adding the flavoring agent, wherein the adding process comprises mixing and standing.
The invention also provides application of the medical oral paraffin oil composition with improved mouthfeel in preparing a medicament for treating incomplete intestinal obstruction.
Compared with the prior art, the invention has the beneficial effects that:
1. the flavoring agent proportion is the amount used when the taste of the medical oral paraffin oil is improved through experimental research, the curative effect of the medicine is not influenced, the clarity of the medicine is not influenced, and the safety of the medicine use is not influenced.
2. The sweetener used in the invention is a high sweetness multiple sweetener which is not metabolized by human body, the sweetness multiple can be adjusted, the taste types can be blended according to the requirements, different requirements of different people on the taste of the preparation are ensured, the taste is good, the application is wide, the requirements of special people on the flavoring agent are met, the product is particularly suitable for children, old people and patients with diabetes, the compliance of the patients is increased, and the market prospect is wide.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the described embodiments of the invention without inventive step, are within the scope of protection of the invention.
The medical oral paraffin oil composition for improving the mouthfeel provided by the following embodiment comprises medical oral paraffin oil and a flavoring agent, wherein the adding mass of the flavoring agent accounts for 0.5-10% of the total mass of the medical oral paraffin oil composition, or the adding volume of the flavoring agent accounts for 0.5-10% of the total volume of the medical oral paraffin oil composition; wherein the taste corrective is a taste corrective for disturbing human taste and olfactory organ to sense medical oral paraffin oil taste by self taste and odor, and comprises sweetener, or mixture of sweetener and aromatic, wherein the sweetener can be selected from one or more of saccharin sodium, sucralose, aspartame, neotame, and acesulfame potassium; the aromatic is selected from one or more of herba Menthae type essence, fructus Citri Limoniae type essence, fructus Jujubae type essence, fortunella margarita (lour.) Swingle type essence, flos Osmanthi Fragrantis type essence, cortex Cinnamomi type essence, vanillin, geraniol and citral.
Example 1
The embodiment provides a medical oral paraffin oil composition for improving mouthfeel, which comprises the following components: 1000mL of medical oral paraffin oil, 3g of saccharin sodium, 10g of acesulfame potassium and 10mL of red date type essence.
The preparation method comprises the following steps: taking 1000mL of medical oral paraffin oil, adding 3g of saccharin sodium, 10g of acesulfame potassium and 10mL of red date type essence, stirring to dissolve, and standing to obtain the oral paraffin oil.
The sweetening agent and the aromatic agent are added in the embodiment, so that the clarity of a final product can be guaranteed, the obtained medical oral paraffin oil composition is sweet in taste and fragrant in smell, and the dosage of a patient is unchanged when the composition is used.
The auxiliary materials for flavoring in the embodiment meet the requirements of pharmaceutical auxiliary materials and related food additives of Chinese pharmacopoeia in 2010, and can obviously improve the taste of the medical oral paraffin oil. Through the investigation of stability tests, after the test is accelerated for 6 months and the test is placed at room temperature for 18 months, the clarity of the medical oral paraffin oil adopting the flavoring method meets the requirements.
Example 2
The embodiment provides a medical oral paraffin oil composition for improving mouthfeel, which comprises the following components: 1000mL of paraffin oil and 10g of sucralose are taken orally.
The preparation method comprises the following steps: and adding 10g of sucralose into 1000mL of medical oral paraffin oil, uniformly mixing, and standing to obtain the oral liquid.
The sweetening agent is added in the embodiment, so that the clarity of a final product can be guaranteed, the obtained medical oral paraffin oil composition is slightly sweet at the entrance, and the dosage of a patient is unchanged.
The auxiliary materials for flavoring in the embodiment meet the requirements of pharmaceutical auxiliary materials and related food additives of Chinese pharmacopoeia in 2010, and can obviously improve the taste of the medical oral paraffin oil. Through stability test investigation, after accelerated investigation for 6 months and room temperature standing for 18 months, the clarity of the medical oral paraffin oil adopting the flavoring method meets the requirements.
Example 3
This example provides a medical paraffin oil composition for oral administration with improved mouthfeel, which comprises the following components: 2000mL of medical oral paraffin oil, 3g of saccharin sodium, 0.5g of neotame, 10mL of Hami melon essence and 4g of citral.
The preparation method comprises the following steps: adding 3g of saccharin sodium and 0.5g of neotame into 2000mL of medical oral paraffin oil; and mixing 10mL of Hami melon essence and 4g of citral, standing, and packaging.
The sweetening agent and the flavoring agent are added to ensure the clarity of the final product, and the oral paraffin oil prepared by the method has sweet taste and fragrant smell, and the dosage of a patient is not changed when the oral paraffin oil is used.
The auxiliary materials for flavoring in the embodiment meet the requirements of pharmaceutical auxiliary materials and related food additives of Chinese pharmacopoeia in 2010, and can obviously improve the taste of the medical oral paraffin oil. Through stability test investigation, after accelerated investigation for 6 months and room temperature standing for 18 months, the clarity of the medical oral paraffin oil adopting the flavoring method meets the requirements.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. It will be readily apparent to those skilled in the art that various modifications to these embodiments and the generic principles defined herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above-described embodiments. Those skilled in the art should appreciate that many modifications and variations are possible in light of the above teaching without departing from the scope of the invention.
Claims (9)
1. The medical oral paraffin oil composition for improving the mouthfeel is characterized by comprising medical oral paraffin oil and a flavoring agent, wherein the adding mass of the flavoring agent accounts for 0.5-10% of the total mass of the medical oral paraffin oil composition, or the adding volume of the flavoring agent accounts for 0.5-10% of the total volume of the medical oral paraffin oil composition.
2. The medical oral paraffin oil composition for improving mouthfeel according to claim 1, wherein the flavoring agent is a flavoring agent which disturbs human taste and smell organs to sense the taste of the medical oral paraffin oil by self taste and smell, and comprises a sweetener, or a mixture of the sweetener and a flavoring agent.
3. The medical oral paraffin oil composition for improving mouthfeel according to claim 2, wherein the sweetener is selected from one or more of saccharin sodium, sucralose, aspartame, neotame and acesulfame potassium.
4. The medical oral paraffin oil composition for improving mouthfeel according to claim 3, wherein the sweetener is selected from at least two or more of saccharin sodium, sucralose, aspartame, neotame and acesulfame potassium when used alone.
5. The medical oral paraffin oil composition for improving mouthfeel according to claim 2, wherein the aromatic is selected from one or more of mint type essence, lemon type essence, red date type essence, kumquat type essence, osmanthus type essence, cinnamon type essence, vanillin, geraniol and citral.
6. The method for preparing medical oral paraffin oil composition for improving mouthfeel according to any one of claims 1 to 5, which is characterized by comprising the following steps: and adding the flavoring agent into the medical oral paraffin oil, dissolving, uniformly mixing and bottling to obtain the oral paraffin oil.
7. The method for preparing medical oral paraffin oil composition for improving mouthfeel according to claim 6, wherein the flavoring agent is dissolved in the medical oral paraffin oil, and the dissolving and mixing method is selected from ultrasound, shaking and stirring.
8. The method for preparing the paraffin oil composition for oral administration for medical use according to claim 6, which improves mouthfeel,
the sweetening agent and the flavoring agent are added in no sequence when the same type is used independently, and can be added simultaneously;
when the sweetening agent and the aromatic agent are used simultaneously, the sweetening agent is added firstly, and the adding process comprises mixing and standing; adding the flavoring agent, and mixing and standing.
9. Use of the oral paraffin oil composition for medical use for improving mouthfeel according to any one of claims 1 to 5 for the preparation of a medicament for treating incomplete ileus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310005497.5A CN115969821A (en) | 2023-01-04 | 2023-01-04 | Medical oral paraffin oil composition for improving mouthfeel and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310005497.5A CN115969821A (en) | 2023-01-04 | 2023-01-04 | Medical oral paraffin oil composition for improving mouthfeel and application thereof |
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| CN115969821A true CN115969821A (en) | 2023-04-18 |
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| CN202310005497.5A Pending CN115969821A (en) | 2023-01-04 | 2023-01-04 | Medical oral paraffin oil composition for improving mouthfeel and application thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998002143A1 (en) * | 1996-07-16 | 1998-01-22 | Jørgen Kruuse A/S | An orally administrable, paste-like composition for veterinary use, a method for the preparation thereof, and the use of an oily vehicle for the manufacture of such composition |
| US5817330A (en) * | 1994-02-25 | 1998-10-06 | Doat; Bernard | Liquid paraffin oil and lactulose-based hypocaloric laxative jelly and method for its preparation |
-
2023
- 2023-01-04 CN CN202310005497.5A patent/CN115969821A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5817330A (en) * | 1994-02-25 | 1998-10-06 | Doat; Bernard | Liquid paraffin oil and lactulose-based hypocaloric laxative jelly and method for its preparation |
| WO1998002143A1 (en) * | 1996-07-16 | 1998-01-22 | Jørgen Kruuse A/S | An orally administrable, paste-like composition for veterinary use, a method for the preparation thereof, and the use of an oily vehicle for the manufacture of such composition |
Non-Patent Citations (3)
| Title |
|---|
| 于永文;: "石蜡油蓖麻油合剂治疗单纯性肠梗阻的体会", 中国临床医生, no. 4, pages 23 - 24 * |
| 徐晓波;张崇杰;马文博;吕渐成;: "石蜡油治疗粘连性肠梗阻52例临床观察", 中国医药指南, no. 05, pages 71 - 72 * |
| 王传堂;刘红;赵巍;: "腹部影像学检查前结肠清洁方法的研究进展", 中国中西医结合影像学杂志, no. 03, pages 211 - 214 * |
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