CN115956887B - Pulse wave signal processing method and device, electronic equipment and storage medium - Google Patents
Pulse wave signal processing method and device, electronic equipment and storage medium Download PDFInfo
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Abstract
The present invention relates to the field of pulse wave signal processing technologies, and in particular, to a pulse wave signal processing method, device, electronic apparatus, and storage medium. The pulse wave signal processing method comprises the following steps: continuously applying a first pressure at a first position of a target blood vessel, wherein the first position is an upstream position of the target blood vessel, applying an external pressure signal at a second position of the target blood vessel, wherein the second position is at a downstream position of the first position and adjacent to the first position, acquiring a first pulse wave signal of the downstream position of the target blood vessel, acquired by a data acquisition device, and determining a quantization index of the target blood vessel according to the external pressure signal and the first pulse wave signal, wherein the quantization index is a quantization index for indicating elasticity of the target blood vessel.
Description
Technical Field
The present invention relates to the field of pulse wave signal processing technologies, and in particular, to a pulse wave signal processing method, device, electronic apparatus, and storage medium.
Background
Vascular disease system assessment and intervention are one of the important detection and treatment projects in cardiovascular clinic at present. Besides visual imaging means, the elastic function detection can be performed, so that the detection of vascular structures and functional lesions is completed. In addition, detection by various biomarkers and the like is also possible, but these methods have different problems.
In various cardiovascular function models established based on nonlinear pulse wave theory, arterial elasticity is an important parameter or index for evaluating cardiovascular function of a human body. However, it is difficult to measure the exact values of the above parameters using only non-invasive means, so calculating other parameters using established non-linear models is extremely prone to large errors.
Disclosure of Invention
The embodiment of the invention provides a pulse wave signal processing method, a pulse wave signal processing device, electronic equipment and a storage medium, which can be used for noninvasively and accurately detecting the elasticity of blood vessels.
In a first aspect, an embodiment of the present application provides a method for processing a pulse wave signal, including: continuously applying a first pressure at a first position of a target blood vessel, wherein the first position is an upstream position of the target blood vessel, applying an external pressure signal at a second position of the target blood vessel, wherein the second position is at a downstream position of the first position and adjacent to the first position, acquiring a first pulse wave signal of the downstream position of the target blood vessel acquired by a data acquisition device, and determining a quantization index of the target blood vessel according to the external pressure signal and the first pulse wave signal, wherein the quantization index is a quantization index for indicating elasticity of the target blood vessel.
Optionally, the first pressure is greater than a systolic pressure of the user; the determining, according to the external pressure signal and the first pulse wave signal, a quantization index of a target blood vessel, where the quantization index is a quantization index for indicating elasticity of the target blood vessel, includes: and carrying out pull-type transformation on the external pressure signal to obtain a first objective function, carrying out pull-type transformation on the first pulse wave signal to obtain a second objective function, and determining the quantization index of the target blood vessel according to the first objective function and the second objective function.
Optionally, the first pressure is an average arterial pressure of the user, and the determining, according to the external pressure signal and the first pulse wave signal, a quantization index of the target blood vessel, where the quantization index is a quantization index for indicating elasticity of the target blood vessel, includes: obtaining a second pulse wave signal of a third position acquired by a data acquisition device, wherein the third position is a position on the other side of the user body corresponding to the downstream position of the target blood vessel, simulating the third pulse wave signal according to the second pulse wave signal, wherein the third pulse wave signal is a pulse wave signal of the downstream position of the target blood vessel, from which the influence of an external pressure signal is removed, obtaining a fourth pulse wave signal, which is the difference between the first pulse wave signal and the third pulse wave signal, performing pull-type transformation on the external pressure signal to obtain a first objective function, performing pull-type transformation on the fourth pulse wave signal to obtain a second objective function, and determining the quantization index of the target blood vessel according to the first objective function and the second objective function.
Optionally, the determining the quantization index of the target blood vessel according to the first objective function and the second objective function includes: and determining a first quantization index according to the maximum value and the equivalent width of the waveform amplitude of the first objective function and the maximum value and the equivalent width of the waveform amplitude of the second objective function, wherein the first quantization index is used for indicating the vascular elasticity of the target blood vessel.
Optionally, the determining the quantization index of the target blood vessel according to the first objective function and the second objective function includes: and determining a second quantization index according to the central frequency of the first objective function and the central frequency of the second objective function, wherein the second quantization index is used for indicating the vascular elasticity of the target blood vessel.
Optionally, the external pressure signal includes: the external pressure signal has a period of heart rate of the user, and the amplitude of the external pressure signal is larger than the diastolic pressure of the user and smaller than or equal to the average value of the systolic pressure and the mean arterial pressure of the user.
Optionally, before the continuously applying the first pressure at the first location of the target vessel, the method further comprises: the method comprises the steps of obtaining a fifth pulse wave signal of a downstream position of a target blood vessel, which is collected by a data collection device, continuously applying a second pressure at the first position, wherein the second pressure is larger than the contraction pressure of a user, stopping applying the second pressure after a preset time, obtaining a sixth pulse wave signal of the downstream position of the target blood vessel, which is collected by the data collection device, and determining a quantization index of the target blood vessel according to the fifth pulse wave signal and the sixth pulse wave signal, wherein the quantization index is a quantization index for indicating the elasticity of the target blood vessel.
In a second aspect, an embodiment of the present application provides a processing device for pulse wave signals, including a processor and a memory, where the memory stores computer instructions that, when executed by the processor, implement the steps of the method according to any one of the first aspect.
In a third aspect, an embodiment of the present application provides an electronic device, including a processor and a memory, where the memory stores computer instructions that, when executed by the processor, perform the steps of the method according to any one of the first aspect above.
In a fourth aspect, embodiments of the present application provide a storage medium having stored thereon computer instructions which, when executed by a processor, implement the steps of the method of any of the first aspects above.
The method has the advantages that the first pressure is continuously applied to the upstream position of the target blood vessel, the external pressure signal is applied to the position adjacent to the upstream position, the first pulse wave signal acquired by the data acquisition device at the downstream position of the target blood vessel is acquired, and the quantitative index indicating the elasticity of the blood vessel is determined according to the external pressure signal and the first pulse wave signal. By the method, the vascular elasticity of the target blood vessel can be indicated more accurately, and the problem of large measurement error of a non-invasive means is solved.
Other features of embodiments of the present invention and its advantages will become apparent from the following detailed description of exemplary embodiments of the invention, which refers to the accompanying drawings.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description, serve to explain the principles of the embodiments of the invention.
Fig. 1 shows a flowchart of a method for processing a pulse wave signal according to an embodiment of the present invention.
Fig. 2 is a schematic diagram showing an example of a pulse wave signal processing method according to an embodiment of the present invention.
Fig. 3 is a waveform diagram showing an example of a pulse wave signal processing method according to an embodiment of the present invention.
Fig. 4 is a waveform diagram showing another example of a processing method of a pulse wave signal according to an embodiment of the present invention.
Fig. 5 shows a block diagram of a pulse wave signal processing apparatus according to an embodiment of the present invention.
Detailed Description
Various exemplary embodiments of the present invention will now be described in detail with reference to the accompanying drawings. It should be noted that: the relative arrangement of the components and steps, numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless it is specifically stated otherwise.
The following description of at least one exemplary embodiment is merely exemplary in nature and is in no way intended to limit the invention, its application, or uses.
Techniques, methods, and apparatus known to one of ordinary skill in the relevant art may not be discussed in detail, but are intended to be part of the specification where appropriate.
In all examples shown and discussed herein, any specific values should be construed as merely illustrative, and not a limitation. Thus, other examples of exemplary embodiments may have different values.
It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further discussion thereof is necessary in subsequent figures.
Fig. 1 shows a flowchart of a method for processing a pulse wave signal according to an embodiment of the present invention. As shown in fig. 1, the method includes steps S11 to S14.
Step S11, continuously applying a first pressure at a first position of the target blood vessel, wherein the first position is an upstream position of the target blood vessel.
In one example of this embodiment, the target blood vessel may be any blood vessel in the user's body that needs to be detected, such as a section of blood vessel from the user's upper arm to the user's wrist or a section of blood vessel in the leg. The first position of the target vessel, which is the position upstream of the target vessel determined from the blood flow direction in the target vessel, may be a certain position of the upper arm in this example.
In one example of this embodiment, the first pressure is continuously applied at the first location of the target vessel, and the first pressure may be continuously applied to the first location of the target vessel through the cuff, for example, the cuff may be tied to the left arm of the user and inflated, and the magnitude of the first pressure is controlled by the magnitude of the first pressure at best so that the cuff continuously applies the first pressure to the upstream location of the target vessel.
In one example of this embodiment, the first pressure may be the mean arterial pressure of the user, and when the first pressure is kept at the mean arterial pressure of the user, the target blood vessel can be completely expanded and can be regarded as a rigid tube, and at this time, the target blood vessel is similar to a linear system, and a more accurate quantitative index of the blood vessel elasticity can be obtained.
In another example of this embodiment, the first pressure may be greater than the systolic pressure of the user, so that the pulse wave of the user himself in the target blood vessel is blocked, and it is convenient to determine the quantitative indicator of the elasticity of the target blood vessel.
It should be noted that, although the example describes that the magnitude of the first pressure may be the mean arterial pressure of the user or may be greater than the systolic pressure of the user, those skilled in the art will understand that the present invention is not limited thereto, and the specific magnitude of the first pressure may be flexibly set according to actual situations or personal preference.
Step S12, applying an external pressure signal at a second location of the target vessel, the second location being downstream of the first location and adjacent to the first location.
In one example of this embodiment, the second position is a position adjacent to and downstream of the first position, which may be an upstream position of the target blood vessel, for example, the cuff 1, when the target blood vessel is a segment of the blood vessel from the upper right arm to the wrist of the user, as shown in fig. 2, and the second position is a position downstream of and adjacent to the first position, which may be a position where the cuff 2 is located in fig. 2.
In one example of this embodiment, the external pressure signal includes: the period of the external pressure signal is the heart rate period of the user, and the amplitude of the external pressure signal is larger than the diastolic pressure of the user and smaller than or equal to the average value of the systolic pressure and the mean arterial pressure of the user.
In this embodiment, the type of the external pressure signal may be a triangle signal, a pulse signal, or a cosine signal, and the amplitude of the external pressure signal may be periodically fluctuated. For example, the external pressure signal may be a cosine signal f (t), the expression of f (t) being as shown in the formula:
wherein, a is the amplitude of the external pressure signal, T is the period of the external pressure signal, and specifically, the period of the external pressure signal may be the heart rate period of the user, and the amplitude of the external pressure signal should be greater than the diastolic pressure of the user and less than the systolic pressure of the user. In one example, to obtain a more accurate quantitative indicator, the amplitude of the external pressure signal may be greater than the user's diastolic pressure and less than or equal to the average of the user's systolic pressure and the mean arterial pressure, i.e.:
。
it should be noted that, although the examples describe that the type of the external pressure signal may be a triangle signal, a pulse signal, or a cosine signal, those skilled in the art can understand that the present invention is not limited thereto, and the type of the external pressure signal may be flexibly set according to actual circumstances.
Step S13, a first pulse wave signal of a downstream position of a target blood vessel acquired by the data acquisition device is acquired.
In one example of this embodiment, the data acquisition device may be a pulse sensor, which may be disposed at a position downstream of the target blood vessel, for example, when the target blood vessel is a segment of a blood vessel from an upper arm to a wrist of the user, the pulse sensor may be disposed at the wrist position to acquire a pulse wave signal at the position downstream of the target blood vessel.
Step S14, determining a quantization index of the target blood vessel according to the external pressure signal and the first pulse wave signal, wherein the quantization index is used for indicating the elasticity of the target blood vessel.
In this example, a first pressure is continuously applied to an upstream position of a target blood vessel, an external pressure signal is applied to a position adjacent to the upstream position, a first pulse wave signal acquired by a data acquisition device at a downstream position of the target blood vessel is acquired, and a quantization index indicating the elasticity of the blood vessel is determined based on the external pressure signal and the first pulse wave signal. By the method, the vascular elasticity of the target blood vessel can be indicated more accurately, and the problem of large measurement error of a non-invasive means is solved.
In one example of the present embodiment, the first pressure is greater than the systolic pressure of the user, and the quantization index of the target blood vessel is determined according to the external pressure signal and the first pulse wave signal, the quantization index being a quantization index for indicating the elasticity of the target blood vessel, including: carrying out pull-type transformation on the external pressure signal to obtain a first objective function, carrying out pull-type transformation on the first pulse wave signal to obtain a second objective function, and determining the quantization index of the target blood vessel according to the first objective function and the second objective function.
In one example of this embodiment, the first pressure may be greater than the systolic pressure of the user, so that the pulse wave signal of the user in the target blood vessel is blocked, and at this time, the first pulse wave signal of the data acquisition device at the position downstream of the target blood vessel is the output signal of the external pressure signal that does not overlap the pulse wave signal of the user and passes through the target blood vessel. Performing pull-type transformation on the external pressure signal to obtain a first objective function; and simultaneously, carrying out pull-type transformation on the first pulse wave signal to obtain a second objective function, and determining the quantization index of the target blood vessel according to the first objective function and the second objective function.
In this example, the first pressure greater than the systolic pressure of the user is continuously applied to the upstream position of the target blood vessel, so as to block the pulse wave signal of the user, thereby obtaining the first pulse wave signal which is acquired by the data acquisition device at the downstream position of the target blood vessel and is not overlapped by the pulse wave signal of the user. By the method, the first pulse wave signals meeting the requirements can be obtained without filtering the first pulse wave signals by a filter, and the quantitative index indicating the vascular elasticity of the target blood vessel can be obtained more accurately without processing the first pulse wave signals.
In one example of the present embodiment, determining a quantization index of a target vessel from a first objective function and a second objective function includes: and determining a first quantization index according to the maximum value and the equivalent width of the waveform amplitude of the first objective function and the maximum value and the equivalent width of the waveform amplitude of the second objective function, wherein the first quantization index is used for indicating the vascular elasticity of the target blood vessel.
In one example of this embodiment, the softer the vessel, the more energy that can be stored, the greater the energy that the external pressure signal loses to propagate in the target vessel, and the greater the waveform deformation of the external pressure signal after pull-type conversion, due to the elasticity of the vessel. The expression of the first quantization index P1 is thus as follows:
as shown in fig. 3, H1 is the maximum value of the waveform amplitude of the first objective function, H2 is the maximum value of the waveform amplitude of the second objective function, D1 is the equivalent width of the waveform of the first objective function, and D2 is the equivalent width of the waveform of the second objective function, that is, the waveform width when the waveform amplitude is greater than the preset threshold, where in this example, the preset threshold may be set to 30% of the waveform amplitude.
In this example, the first objective function and the second objective function are obtained through the pull transformation, so that the maximum value and the equivalent width of the waveform amplitude of the first objective function and the waveform amplitude of the second objective function can be determined, and further, the quantization index indicating the elasticity of the target blood vessel can be accurately determined according to the maximum value and the equivalent width of the waveform amplitude of the first objective function and the waveform amplitude of the second objective function.
In another example of the present embodiment, determining a quantization index of a target vessel according to a first objective function and a second objective function includes: and determining a second quantization index according to the central frequency of the first objective function and the central frequency of the second objective function, wherein the second quantization index is used for indicating the vascular elasticity of the target blood vessel.
In one example of the present embodiment, since the softer the blood vessel, the more energy can be stored, the greater the energy lost by the propagation of the external pressure signal in the target blood vessel, the more the external pressure signal changes in the frequency domain after the waveform of the pull-type transformation, the center frequency of which will shift to the left, resulting in the change of the S1 part area and the S2 part area as shown in fig. 4, and therefore the expression of the second quantization index P2 is as shown in the formula:
where S11 is the area under the curve of the pulse wave from the lower limit cutoff frequency fl to the center frequency f0 of the first objective function, S12 is the area under the curve of the pulse wave from the lower limit cutoff frequency fl to the center frequency f0 of the second objective function, S21 is the area under the curve of the pulse wave from the center frequency f0 to the upper limit cutoff frequency fh of the first objective function, and S22 is the area under the curve of the pulse wave from the center frequency f0 to the upper limit cutoff frequency fh of the second objective function.
In one example of the present embodiment, in order to obtain a better detection effect, the preset frequency may be used to replace the center frequency in the above example, for example, the preset frequency may be 5hz, the center frequencies of the first objective function and the second objective function are replaced with the preset frequency, and the second quantization index P2 is calculated.
In this example, the first objective function and the second objective function are obtained through the pull transformation, so that the center frequencies of the first objective function and the second objective function can be determined, and further, according to the center frequencies of the first objective function and the second objective function, the quantization index indicating the elasticity of the target blood vessel can be accurately determined.
In one example of the present embodiment, the transfer function of the target vessel is determined from the first and second objective functions.
In this embodiment, the transfer function TF(s) of the target blood vessel can also be calculated according to the first objective function X(s) and the second objective function Y(s), as shown in the formula:
in this embodiment, after the transfer function of the target blood vessel is obtained, the new cardiovascular related quantization index may be further analyzed or extracted according to the effective information including the human blood vessel function, such as the amplitude, the first derivative, the second derivative, the envelope shape, the amplitude-frequency characteristic, the phase-frequency characteristic, and the like of the transfer function curve.
In one example of the present embodiment, the first pressure is an average arterial pressure of the user, and the determining a quantization index of the target blood vessel according to the external pressure signal and the first pulse wave signal, the quantization index being a quantization index for indicating elasticity of the target blood vessel includes: and acquiring a second pulse wave signal of a third position acquired by the data acquisition device, wherein the third position is a position on the other side of the user body corresponding to the downstream position of the target blood vessel. And simulating a third pulse wave signal according to the second pulse wave signal, wherein the third pulse wave signal is a pulse wave signal of a target blood vessel downstream position, which is influenced by the external pressure signal, is removed, and a fourth pulse wave signal is obtained, and is the difference between the first pulse wave signal and the third pulse wave signal. Carrying out pull-type transformation on the external pressure signal to obtain a first objective function, carrying out pull-type transformation on the fourth pulse wave signal to obtain a second objective function, and determining the quantization index of the target blood vessel according to the first objective function and the second objective function.
When the first pressure is set as the mean arterial pressure of the user, the target blood vessel can be completely expanded, so that a more accurate quantitative index of the blood vessel elasticity is obtained. Meanwhile, the first pulse wave signals acquired by the data acquisition device are superposition of external pressure signals and pulse wave signals of the user, and filtering is needed for acquiring accurate second objective functions. For example, as shown in fig. 2, fig. 2 is a schematic diagram of the user's arms, and the target vessel is a section of the blood vessel from the user's upper right arm to the user's right wrist. The cuff 1 is inflated using an air pump such that the cuff 1 continuously applies a first pressure of a magnitude equal to the mean arterial pressure of the user at a first location of the target vessel and an external pressure signal is applied at a second location through the cuff 2.
A first pulse wave signal of a target blood vessel downstream position acquired by the pulse sensor 1 is acquired. In this example, the first pulse wave signal may be a mixed signal d (t) of the user' S own pulse wave signal P (t) and the output signal S (t) of the external pressure signal. In order to remove the influence of the pulse wave signal of the user, the data acquisition device arranged at the position of the other side of the user body corresponding to the downstream position of the target blood vessel, namely the pulse sensor at the left wrist, can be used for simulating the acquired second pulse wave signal P' (t), and the pulse wave signal P (t) of the user at the downstream position of the target blood vessel, which is influenced by the external pressure signal, is simulated by the formula
It can be seen that the output signal S (t) of the clean external pressure signal, i.e., the fourth pulse wave signal, can be obtained by subtracting p (t) from d (t). Performing pull-type transformation on the external pressure signal to obtain a first objective function; and simultaneously, carrying out pull-type transformation on the fourth pulse wave signal to obtain a second objective function, and determining the quantization index of the target blood vessel according to the first objective function and the second objective function.
In this example, by continuously applying the first pressure of the mean arterial pressure of the user at a location upstream of the target vessel, a more accurate quantitative indicator of vessel elasticity can be obtained. And the pulse wave signal of the user at the position of the downstream of the target blood vessel is simulated by the pulse wave signal of the position of the other side of the user body corresponding to the position of the downstream of the target blood vessel, so that the output signal of the clean external pressure signal is obtained. In this way, the first pulse wave signal may be filtered to obtain a satisfactory signal, and the signal may be further processed to obtain a more accurate quantitative indicator indicative of the vascular elasticity of the target blood vessel.
In one example of this embodiment, the method further comprises, prior to the continuously applying the first pressure at the first location of the target vessel: the method comprises the steps of obtaining a fifth pulse wave signal of a target blood vessel downstream position collected by a data collection device, continuously applying a second pressure at a first position, wherein the second pressure is larger than the contraction pressure of a user, stopping applying the second pressure after a preset time, obtaining a sixth pulse wave signal of the target blood vessel downstream position collected by the data collection device, and determining a quantization index of the target blood vessel according to the fifth pulse wave signal and the sixth pulse wave signal, wherein the quantization index is a quantization index for indicating the elasticity of the target blood vessel.
In one example of this embodiment, a second pressure greater than the user's systolic pressure may be continuously applied at a location upstream of the target vessel, allowing the target vessel to occlude for a period of time before releasing, i.e., a reactive hyperemia process. Since blood vessels before and after reactive congestion are dilated to cause a change in pulse wave signals, a quantitative indicator indicating the vascular elasticity of a target blood vessel can be determined by acquiring pulse wave signals before and after reactive congestion.
For example, as shown in fig. 2, the cuff 1 is located at a first position, and before the cuff 1 is inflated, a pulse wave signal before the reactive hyperemia of the user can be acquired by a pulse sensor at a position downstream of the target blood vessel, and after the acquisition, the cuff 1 can be inflated, and a second pressure greater than the systolic pressure of the user is continuously applied at the first position, so that the blood flow is blocked. After the preset time, in this example, the preset time may be 5 minutes, the cuff 1 is deflated, that is, the application of the second pressure is stopped, at this time, the pulse wave signal after the reactive hyperemia of the user is collected by the pulse sensor at the downstream position of the target blood vessel, and according to the pulse wave signals collected twice, in combination with the foregoing example, a quantization index indicating the blood vessel elasticity of the target blood vessel may be obtained.
In this example, the user is brought into the reactive hyperemia state by continuously applying the second pressure to the upstream position of the target blood vessel, pulse wave signals before and after the reactive hyperemia are measured, and a quantitative index indicating the elasticity of the target blood vessel is accurately determined from the pulse wave signals before and after the reactive hyperemia.
Referring to fig. 5, the present embodiment provides a processing apparatus 100 for pulse wave signals, including a processor 101 and a memory 102, where the memory 102 stores computer instructions, and each process of the above-mentioned processing method embodiment for pulse wave signals is implemented when the computer instructions are executed by the processor 101, and the same technical effects can be achieved, so that repetition is avoided and redundant description is omitted here.
The embodiment provides an electronic device, which includes a processor and a memory, where the memory stores computer instructions, and when the computer instructions are executed by the processor, the processes of the above-mentioned pulse wave signal processing method embodiment are implemented, and the same technical effects can be achieved, so that repetition is avoided, and no redundant description is provided herein.
The present embodiment provides a computer readable storage medium, in which executable commands are stored, where the executable commands implement each process of the above-mentioned pulse wave signal processing method embodiment when executed by a processor, and the same technical effects can be achieved, so that repetition is avoided, and no detailed description is given here.
The embodiments of the present invention are described in a progressive manner, and the same and similar parts of the embodiments are all referred to each other, and each embodiment is mainly described in the differences from the other embodiments. In particular, for the apparatus, device embodiments, since they are substantially similar to the method embodiments, the description is relatively simple, as relevant to see the section description of the method embodiments.
The foregoing describes certain embodiments of the present invention. Other embodiments are within the scope of the following claims. In some cases, the actions or steps recited in the claims can be performed in a different order than in the embodiments and still achieve desirable results. In addition, the processes depicted in the accompanying figures do not necessarily require the particular order shown, or sequential order, to achieve desirable results. In some embodiments, multitasking and parallel processing are also possible or may be advantageous.
Embodiments of the invention may be a system, method, and/or computer program product. The computer program product may include a computer readable storage medium having computer readable program instructions embodied thereon for causing a processor to implement aspects of embodiments of the present invention.
The computer readable storage medium may be a tangible device that can hold and store instructions for use by an instruction execution device. The computer readable storage medium may be, for example, but not limited to, an electronic storage device, a magnetic storage device, an optical storage device, an electromagnetic storage device, a semiconductor storage device, or any suitable combination of the foregoing. More specific examples (a non-exhaustive list) of the computer-readable storage medium would include the following: portable computer disks, hard disks, random Access Memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM or flash memory), static Random Access Memory (SRAM), portable compact disk read-only memory (CD-ROM), digital Versatile Disks (DVD), memory sticks, floppy disks, mechanical coding devices, punch cards or in-groove structures such as punch cards or grooves having instructions stored thereon, and any suitable combination of the foregoing. Computer-readable storage media, as used herein, are not to be construed as transitory signals per se, such as radio waves or other freely propagating electromagnetic waves, electromagnetic waves propagating through waveguides or other transmission media (e.g., optical pulses through fiber optic cables), or electrical signals transmitted through wires.
The computer readable program instructions described herein may be downloaded from a computer readable storage medium to a respective computing/processing device or to an external computer or external storage device over a network, such as the internet, a local area network, a wide area network, and/or a wireless network. The network may include copper transmission cables, fiber optic transmissions, wireless transmissions, routers, firewalls, switches, gateway computers and/or edge servers. The network interface card or network interface in each computing/processing device receives computer readable program instructions from the network and forwards the computer readable program instructions for storage in a computer readable storage medium in the respective computing/processing device.
Computer program instructions for carrying out operations of embodiments of the present invention may be assembly instructions, instruction Set Architecture (ISA) instructions, machine-related instructions, microcode, firmware instructions, state setting data, or source or object code written in any combination of one or more programming languages, including an object oriented programming language such as Smalltalk, c++ or the like and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The computer readable program instructions may be executed entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any kind of network, including a Local Area Network (LAN) or a Wide Area Network (WAN), or may be connected to an external computer (for example, through the Internet using an Internet service provider). In some embodiments, aspects of embodiments of the present invention are implemented by personalizing electronic circuitry, such as programmable logic circuitry, field Programmable Gate Arrays (FPGAs), or Programmable Logic Arrays (PLAs), with state information for computer readable program instructions, which may execute the computer readable program instructions.
Aspects of embodiments of the present invention are described herein with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems) and computer program products according to embodiments of the invention. It will be understood that each block of the flowchart illustrations and/or block diagrams, and combinations of blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer-readable program instructions.
These computer readable program instructions may be provided to a processor of a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions/acts specified in the flowchart and/or block diagram block or blocks. These computer readable program instructions may also be stored in a computer readable storage medium that can direct a computer, programmable data processing apparatus, and/or other devices to function in a particular manner, such that the computer readable medium having the instructions stored therein includes an article of manufacture including instructions which implement the function/act specified in the flowchart and/or block diagram block or blocks.
The computer readable program instructions may also be loaded onto a computer, other programmable data processing apparatus, or other devices to cause a series of operational steps to be performed on the computer, other programmable apparatus or other devices to produce a computer implemented process such that the instructions which execute on the computer, other programmable apparatus or other devices implement the functions/acts specified in the flowchart and/or block diagram block or blocks.
The flowcharts and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to various embodiments of the present invention. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of instructions, which comprises one or more executable instructions for implementing the specified logical function(s). In some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems which perform the specified functions or acts, or combinations of special purpose hardware and computer instructions. It is well known to those skilled in the art that implementation by hardware, implementation by software, and implementation by a combination of software and hardware are all equivalent.
The foregoing description of embodiments of the invention has been presented for purposes of illustration and description, and is not intended to be exhaustive or limited to the embodiments disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope of the various embodiments described. The terminology used herein was chosen in order to best explain the principles of the embodiments, the practical application, or the improvement of technology in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.
Claims (10)
1. A method for processing pulse wave signals, comprising:
continuously applying a first pressure at a first location of the target vessel, the first location being an upstream location of the target vessel;
applying an external pressure signal at a second location of the target vessel, the second location being downstream of and adjacent to the first location;
acquiring a first pulse wave signal of a downstream position of the target blood vessel acquired by a data acquisition device;
according to the external pressure signal and the first pulse wave signal, determining a quantization index of the target blood vessel, wherein the quantization index is used for indicating the elasticity of the target blood vessel, and the external pressure signal is a periodically-changing signal.
2. The process of claim 1 wherein the first pressure is greater than a user's systolic pressure; the determining, according to the external pressure signal and the first pulse wave signal, a quantization index of a target blood vessel, where the quantization index is a quantization index for indicating elasticity of the target blood vessel, includes:
carrying out pull-type transformation on the external pressure signal to obtain a first objective function;
carrying out pull-type transformation on the first pulse wave signal to obtain a second objective function;
and determining a quantization index of the target blood vessel according to the first objective function and the second objective function.
3. The method according to claim 1, wherein the first pressure is an average arterial pressure of the user, the determining a quantization index of the target blood vessel based on the external pressure signal and the first pulse wave signal, the quantization index being a quantization index indicating elasticity of the target blood vessel, comprises:
acquiring a second pulse wave signal of a third position acquired by a data acquisition device, wherein the third position is a position on the other side of the user body corresponding to the downstream position of the target blood vessel;
simulating a third pulse wave signal according to the second pulse wave signal, wherein the third pulse wave signal is a pulse wave signal of a position downstream of the target blood vessel, which is influenced by the external pressure signal, is removed;
acquiring a fourth pulse wave signal, wherein the fourth pulse wave signal is the difference between the first pulse wave signal and the third pulse wave signal;
carrying out pull-type transformation on the external pressure signal to obtain a first objective function;
carrying out pull-type transformation on the fourth pulse wave signal to obtain a second objective function;
and determining a quantization index of the target blood vessel according to the first objective function and the second objective function.
4. A method according to claim 2 or 3, wherein determining a quantization index of a target vessel from the first and second objective functions comprises:
and determining a first quantization index according to the maximum value and the equivalent width of the waveform amplitude of the first objective function and the maximum value and the equivalent width of the waveform amplitude of the second objective function, wherein the first quantization index is used for indicating the vascular elasticity of the target blood vessel.
5. A method according to claim 2 or 3, wherein determining a quantization index of a target vessel from the first and second objective functions comprises:
and determining a second quantization index according to the central frequency of the first objective function and the central frequency of the second objective function, wherein the second quantization index is used for indicating the vascular elasticity of the target blood vessel.
6. The processing method according to claim 1, wherein the external pressure signal comprises: any one of a triangle signal, a pulse signal and a cosine signal;
the period of the external pressure signal is the heart rate period of the user, and the amplitude of the external pressure signal is larger than the diastolic pressure of the user and smaller than or equal to the average value of the systolic pressure and the average arterial pressure of the user.
7. The method of treatment of claim 1, wherein prior to said continuously applying the first pressure at the first location of the target vessel, the method further comprises:
acquiring a fifth pulse wave signal of the downstream position of the target blood vessel acquired by the data acquisition device;
continuously applying a second pressure at the first location, the second pressure being greater than the user's systolic pressure;
stopping applying the second pressure after the preset time, and acquiring a sixth pulse wave signal of the downstream position of the target blood vessel, which is acquired by the data acquisition device;
and determining a quantization index of the target blood vessel according to the fifth pulse wave signal and the sixth pulse wave signal, wherein the quantization index is used for indicating the elasticity of the target blood vessel.
8. A pulse wave signal processing device comprising a memory and a processor, the memory for storing a computer program; the processor is configured to execute the computer program to implement the method according to any one of claims 1-7.
9. An electronic device comprising a processor and a memory having stored therein computer instructions which, when executed by the processor, implement the steps of the method of any of claims 1-7.
10. A storage medium having stored thereon computer instructions which, when executed by a processor, implement the steps of the method of any of claims 1-7.
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| CN103156583A (en) * | 2011-12-19 | 2013-06-19 | 国立大学法人广岛大学 | Apparatus for evaluating vascular endothelial function |
| CN113951846A (en) * | 2021-12-17 | 2022-01-21 | 北京麦邦光电仪器有限公司 | Pulse wave signal processing method and device and readable storage medium |
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| TWI359006B (en) * | 2008-04-18 | 2012-03-01 | Hsien Tsai Wu | A device and method for early blood vessel aging d |
| US20150374242A1 (en) * | 2014-06-27 | 2015-12-31 | Prolific Technology Inc. | Method for measureing blood vessel elasticity |
| EP4115799A1 (en) * | 2021-07-09 | 2023-01-11 | Terra Quantum AG | A method and system for converting physiological signals |
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| CN103156583A (en) * | 2011-12-19 | 2013-06-19 | 国立大学法人广岛大学 | Apparatus for evaluating vascular endothelial function |
| CN113951846A (en) * | 2021-12-17 | 2022-01-21 | 北京麦邦光电仪器有限公司 | Pulse wave signal processing method and device and readable storage medium |
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