CN115944858A - Optogenetic peripheral nerve stimulation device and system - Google Patents
Optogenetic peripheral nerve stimulation device and system Download PDFInfo
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- CN115944858A CN115944858A CN202310040381.5A CN202310040381A CN115944858A CN 115944858 A CN115944858 A CN 115944858A CN 202310040381 A CN202310040381 A CN 202310040381A CN 115944858 A CN115944858 A CN 115944858A
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Abstract
The invention relates to a device and a system for stimulating peripheral nerve by optogenetic, wherein the device comprises an implant and an extracorporeal machine, wherein the implant comprises a photoelectrode array and the extracorporeal machine; the photoelectrode array is wrapped on the nerve bundle to be repaired and used for emitting light rays with different wavelengths to realize optogenetic stimulation on the nerve bundle to be repaired; the in-vivo machine is connected with the photoelectrode array, and the in-vivo machine are connected in a wireless communication mode; the in-vivo machine is used for supplying power to the in-vivo machine and sending out a stimulation strategy, and the in-vivo machine is used for controlling the photoelectrode array to work according to the stimulation strategy.
Description
Technical Field
The invention relates to the technical field of nerve repair, in particular to a device and a system for stimulating peripheral nerve by optogenetic.
Background
For a patient with one side of brain injury caused by brain trauma, stroke and the like and left with contralateral limb dysfunction entering a plateau stage, the far end of the cervical 7 nerve which governs the paralyzed upper limb is connected to the near end of the cervical 7 nerve which governs the healthy side upper limb through the left and right cervical 7 cross displacement operation, a nerve conduction path of the healthy side hemicerebral governs the paralyzed upper limb is established, the healthy side cerebral hemisphere governs the paralyzed upper limb, and the motor function of the patient is recovered. At present, the recovery process after the cross displacement of the left and right necks 7 requires about 1 year, and along with the regeneration process of the necks 7 nerves, the recovery rule is as follows: improving the shoulder lifting function after about 3 months of operation, improving the elbow joint movement after 5 months of operation, improving the forearm rotation and wrist stretching function after 8-10 months of operation, and finishing the hand grasping and fine function improvement after nerve regeneration after 10-12 months of operation.
After the peripheral nerve injury such as the cervical 7 nerve is cut and sutured, the repair process is complex, the nerve regeneration speed is slow, and the recovery time required for the central nervous system to adapt to new nerve connection is slow. The functional recovery state after peripheral nerve injury is closely related to the treatment time, 1 percent of functions are lost every 6 days of delay, and the nerve regeneration speed still stays within the range of not more than 1 mm/day, so that the more effective intervention on peripheral nerves always needs to be comprehensive treatment.
Existing research shows that in the nerve repair process, certain electrical stimulation can accelerate the nerve repair process, but the electrical stimulation does not have selectivity because the electrical stimulation can activate all neurons in a large range due to the diffusion characteristic of an electric field. The clinical current electro photoluminescence physiotherapy equipment is mostly large-scale percutaneous electrical stimulation equipment, and the patient need go to the hospital many times and treat, has greatly increased the postoperative cost, and the dispersion of electro photoluminescence also can bring the misery for the patient.
Disclosure of Invention
The invention aims to provide a device and a system for stimulating peripheral nerve by optogenetic, which can provide more precise nerve regulation and promote the functional rehabilitation.
The technical scheme adopted by the invention for solving the technical problems is as follows: the optogenetic peripheral nerve stimulation device comprises an implant and an extracorporeal machine, wherein the implant comprises a photoelectrode array and the extracorporeal machine; the photoelectrode array is wrapped on the nerve bundle to be repaired and used for emitting light rays with different wavelengths to realize optogenetic stimulation on the nerve bundle to be repaired; the in-vivo machine is connected with the photoelectrode array, and the in-vivo machine is connected with the in-vivo machine in a wireless communication mode; the in-vivo machine is used for supplying power to the in-vivo machine and sending out a stimulation strategy, and the in-vivo machine is used for controlling the photoelectrode array to work according to the stimulation strategy.
The photoelectrode array comprises a slender flexible substrate, a plurality of LEDs capable of emitting light rays with different wavelengths are arranged along the length direction of the slender flexible substrate, the slender flexible substrate is twisted into a spiral sleeve, the LEDs are located on the inner side of the spiral sleeve, and the LEDs are connected with the internal machine through leads.
The stimulation strategy is based on the LED lighting time and position generated by the rehabilitation evaluation result of the patient, the rehabilitation evaluation result comprises the evaluation result of the muscle function and action of the patient and the image information of the nerve bundle to be repaired, the LED lighting time is generated according to the evaluation result of the muscle function and action of the patient, and the LED lighting position is generated according to the image information of the nerve bundle to be repaired; different muscle functions and actions correspond to the nerve branches in the nerve bundle to be repaired, and the light rays with different wavelengths correspond to the nerve branches in the nerve bundle to be repaired.
The in-vivo machine comprises a packaging shell and a receiving coil, an in-vivo machine circuit board is arranged in the packaging shell, an in-vivo single chip microcomputer, a carrier receiving circuit and a power circuit are arranged on the in-vivo machine circuit board, the carrier receiving circuit is connected with the receiving coil through an input interface, and the receiving coil is used for receiving energy and information sent by the in-vivo machine; the input end of the in-vivo singlechip is connected with the carrier receiving circuit, and the output end of the in-vivo singlechip is connected with the photoelectrode array through an output interface, and is used for acquiring the stimulation strategy from the received information and controlling the photoelectrode array according to the stimulation strategy; and the power supply circuit is connected with the carrier receiving circuit and used for supplying energy to the singlechip from the received energy.
The in-vivo single chip microcomputer comprises a storage unit, the storage unit is used for storing the stimulation strategy, and when the in-vivo single chip microcomputer does not receive a new stimulation strategy, the in-vivo single chip microcomputer sends a control instruction to the photoelectrode array according to the stimulation strategy in the storage unit.
The receiving coil is packaged in the coil packaging shell, a magnetic core is arranged in the middle of the receiving coil, and a magnetism isolating sheet is arranged between the receiving coil and the coil packaging shell.
The external machine comprises a transmitting coil and an external machine circuit board, an external singlechip and a carrier transmitting circuit which are connected with each other are arranged on the external machine circuit board, the carrier transmitting circuit is connected with the transmitting coil through an interface, and the external singlechip transmits the stimulation strategy to the internal machine through the carrier transmitting circuit and the transmitting coil.
And the external machine circuit board is also provided with a computer interface connected with the external single chip microcomputer.
And the external machine circuit board is also provided with a power supply module for supplying power to the external singlechip.
The technical scheme adopted by the invention for solving the technical problem is as follows: a peripheral nerve stimulation system of optogenetic comprises the peripheral nerve stimulation device of optogenetic, a computer system and a direct current power supply, wherein the computer system and the direct current power supply are connected with an extracorporeal machine, and the computer system is used for generating the stimulation strategy and transmitting the stimulation strategy to the extracorporeal machine; the direct current power supply is used for supplying power to the external machine.
Advantageous effects
Due to the adoption of the technical scheme, compared with the prior art, the invention has the following advantages and positive effects: according to the invention, through the design of the in-vivo machine, the in-vitro machine and the photoelectrode array, after the equipment is implanted, a patient can communicate and control the implant through the in-vitro machine, so that accurate optogenetic stimulation can be realized in the rehabilitation course, and targeted function rehabilitation can be carried out. The whole system of the invention adopts a modular design, has the characteristics of miniaturization and portability, and enables a patient to start optogenetic nerve stimulation at any time and any place to promote nerve repair.
Drawings
FIG. 1 is a block diagram of a first embodiment of the present invention;
FIG. 2 is a schematic view of an implant according to a first embodiment of the present invention;
fig. 3 is a schematic view of the internal structure of an external unit according to a first embodiment of the present invention;
FIG. 4 is a block diagram of a second embodiment of the present invention;
figures 5-10 are illustrations of a particular embodiment of a prototype of the invention applied to peripheral nerves of rodents.
Detailed Description
The invention will be further illustrated with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention can be made by those skilled in the art after reading the teaching of the present invention, and these equivalents also fall within the scope of the claims appended to the present application.
A first embodiment of the present invention relates to a optogenetic peripheral nerve stimulation device, as shown in fig. 1, comprising an implant comprising a photoelectrode array and an extracorporeal machine; the photoelectrode array is wrapped on the nerve bundle to be repaired and used for emitting light rays with different wavelengths to realize optogenetic stimulation on the nerve bundle to be repaired; the in-vivo machine is connected with the photoelectrode array, and the in-vivo machine are connected in a wireless communication mode; the in-vivo machine is used for supplying power to the in-vivo machine and sending out a stimulation strategy, and the in-vivo machine is used for controlling the photoelectrode array to work according to the stimulation strategy.
As shown in fig. 2, the photoelectrode array 1 includes an elongated flexible substrate, a plurality of mini-LEDs capable of emitting light with different wavelengths are arranged along the length direction of the elongated flexible substrate, the elongated flexible substrate is twisted into a spiral sleeve, and the mini-LEDs are located inside the spiral sleeve, and the mini-LEDs are connected with the internal machine through wires. It is easy to find that the flexible substrate on which the mini-LED array is disposed is twisted into the spiral sleeve in this embodiment, so that the implanted photo-electrode array can be ensured to completely wrap the nerve bundle, and the spiral sleeve can be ensured to uniformly dispose the mini-LED array at each position of the nerve bundle. When a specific mini-LED is lighted, the light emitted by the mini-LED can illuminate the nerve bundle aimed by the mini-LED; when the optogenetic protein is expressed well in the nerve bundle, the illumination from the mini-LED will activate its neural activity.
The in-vivo machine in the embodiment comprises a packaging shell 2 and a receiving coil 3, wherein an in-vivo machine circuit board 4 is arranged in the packaging shell 2, an in-vivo singlechip 5, a carrier receiving circuit and a power circuit are arranged on the in-vivo machine circuit board 4, the carrier receiving circuit is connected with the receiving coil 3 through an input interface, and the receiving coil 3 is used for receiving energy and information sent by the in-vitro machine; the input end of the in-vivo singlechip 5 is connected with the carrier receiving circuit, and the output end of the in-vivo singlechip 5 is connected with the photoelectrode array through an output interface, and is used for receiving the stimulation strategy and controlling the photoelectrode array according to the stimulation strategy; and the power supply circuit is connected with the carrier receiving circuit and used for supplying energy to the singlechip from the received energy.
Receiving coil 3 among this embodiment encapsulates in coil encapsulation casing, the centre of receiving coil 3 is provided with magnetic core 6, be provided with the magnetism sheet between receiving coil and the coil encapsulation casing. The magnetic core is arranged in the middle of the receiving coil, so that on one hand, the inductive property of the receiving coil can be enhanced, and on the other hand, the receiving coil and an external machine can be attracted mutually after being implanted into a body, and the fixation of the external machine is facilitated. The magnetism isolating sheet is arranged between the receiving coil and the coil packaging shell, so that electromagnetic signals can be prevented from being absorbed and attenuated by the metal material of the packaging shell, and the energy conversion efficiency is guaranteed. The coil packaging shell and the packaging shell in the embodiment are both packaged by the titanium shell, and have good waterproofness and biocompatibility, so that the implant can work normally.
As shown in fig. 3, the extracorporeal machine includes an extracorporeal machine housing, the extracorporeal machine housing includes a transmitting coil 7 and an extracorporeal machine circuit board 8, the extracorporeal machine circuit board 8 is provided with an extracorporeal single chip microcomputer and a carrier transmitting circuit, which are connected with each other, the carrier transmitting circuit is connected with the transmitting coil 7 through an interface, and the extracorporeal single chip microcomputer transmits the stimulation strategy to the extracorporeal machine through the carrier transmitting circuit and the transmitting coil. The external machine circuit board 8 is also provided with a computer interface 9, the computer interface 9 is connected with the external single chip microcomputer, and the external single chip microcomputer can be connected with an external computer system through the computer interface. The external machine circuit board 8 is also provided with a power module 10 for supplying power to the external single chip microcomputer, and the power module 10 can be a lithium battery.
When the optogenetic peripheral nerve stimulating device of the embodiment is used, the photoelectrode array is required to be wrapped to the nerve bundle to be repaired, then the in-vivo machine is implanted into a patient, when stimulation is carried out, the transmitting coil of the in-vitro machine is aligned to the receiving coil of the in-vivo machine, the power module of the in-vitro machine supplies power to the in-vitro machine, the in-vitro single chip microcomputer is driven to work, and meanwhile, electric energy is transmitted to an implant body in a wireless power supply mode. After the in-vitro single chip microcomputer is started, if a new stimulation strategy exists, the new stimulation strategy is sent by the transmitting coil in a coil carrier communication mode. Then, the external machine enters a loop for monitoring the operation condition of the implant, and periodically sends an operation log to the upper computer for a doctor or a user to evaluate the operation condition of the instrument in real time.
At the end of the implant, after receiving the electric energy of wireless power supply, the in-vivo singlechip of the in-vivo machine is started and waits for the in-vitro machine to start first, so as to confirm whether the in-vitro machine requests communication or not, and further determine whether a new stimulation strategy needs to be received from the in-vitro machine or not. If the external machine does not send a new stimulation strategy, the internal single chip reads the stored stimulation strategy from the EEPROM of the internal single chip to control the photoelectrode array to work and execute the operation circularly. If the in-vivo machine receives a new strategy sent by the in-vitro machine, the new strategy is stored in the EEPROM, and then the in-vivo machine starts to circularly execute the stimulation strategy to control the photoelectrode array to work
When the implant starts to circularly execute the stimulation strategy, the implant can periodically send the running condition to the upper computer in the modes of Bluetooth and the like. If the upper computer receives the communication of the abnormal operation of the implant, the external machine is controlled to be interrupted and cut off, and the whole device is restarted at a proper and safe time.
The stimulation strategy in the embodiment is that an upper computer generates LED lighting time and position based on a rehabilitation evaluation result of a patient, the rehabilitation evaluation result comprises an evaluation result of muscle function and action of the patient and image information of a nerve bundle to be repaired, the LED lighting time is generated according to the evaluation result of the muscle function and action of the patient, and the LED lighting position is generated according to the image information of the nerve bundle to be repaired; different muscle functions and actions correspond to the nerve branches in the nerve bundle to be repaired, and the light rays with different wavelengths correspond to the nerve branches in the nerve bundle to be repaired.
Because the photoelectrode array in the embodiment adopts a spiral design, the photoelectrode array can be wound on a nerve bundle to be repaired, and the mini-LED of the photoelectrode array can be sequentially lightened on time and space according to a stimulation strategy under the control of the stimulation device. With the stimulation device of the present embodiment, the physician can make different nerve branches respond to different wavelengths of light stimulation by selectively expressing different characteristics of the optogenetic proteins (e.g., npHR optogenetic protein responds to yellow light, chR2 optogenetic protein responds to blue light, etc.) on different nerve branches. Because different nerve branches correspond to different muscle functions and actions, single or multiple nerve branches in a nerve bundle can be stimulated in a targeted mode by controlling a mini-LED which is integrated in a photoelectrode array and can emit light with different wavelengths (so as to emit light with different colors). For example, when the recovery effect of the finger joint muscles is poor and the recovery effect of the wrist joint muscles is good in the evaluation result of the muscle functions and actions of the patient, the doctor can prolong the irradiation time of the mini-LED corresponding to the nerve branch affecting the finger joint muscles, so that the accurate adjustment on the time is realized. The doctor can also acquire which position of the optogenetic protein in the nerve bundle to be repaired of the patient is sufficiently expressed based on the image information, and at the moment, the mini-LED at the position can be controlled to be turned on, so that finer nerve regulation and control are provided, the functional rehabilitation of the patient is promoted, and the obtained lighting time and position of the mini-LED are a stimulation strategy. Therefore, compared with the traditional electrical stimulation system, the stimulation device of the embodiment has higher time and space resolution, can selectively stimulate different types of neurons in heterogeneous tissues by utilizing a transgenic means, and has higher treatment pertinence and targeting property.
A second embodiment of the present invention relates to a peripheral nerve stimulation system, as shown in fig. 4, including the peripheral nerve stimulation device of the first embodiment, a computer system and a dc power supply, wherein the computer system and the dc power supply are connected to the extracorporeal machine, and the computer system is configured to generate the stimulation strategy and transmit the stimulation strategy to the extracorporeal machine; the direct current power supply is used for supplying power to the external machine.
In this embodiment, the dc power supply can supply power to the external machine, and the external machine can also supply power through the lithium battery built in the power module. The in vitro single chip microcomputer of the in vitro machine is responsible for interacting with the computer system, and the interaction is usually IDE software (integrated development environment) in the computer system, and the IDE software can read and write programs to the single chip microcomputer or record communication data (wired communication modes such as serial ports or wireless communication modes such as bluetooth) of the single chip microcomputer. The external singlechip transmits the stimulation strategy issued by the computer system to the implant through the carrier transmitting circuit and the transmitting coil.
The implant receives energy and information transmitted from an extra-corporeal unit through the receiving coil. The carrier receiving circuit rectifies and interprets the energy and information received by the coil. The power management module of the implant derives power from the rectification of the carrier receiving circuit to power the circuitry of the implant and to charge the implant battery. The implant battery can enable the implant to provide reasonable duration of endurance under the condition of losing external energy supply. And after the in-vivo singlechip of the implant receives the stimulation strategy interpreted by the carrier receiving circuit, the in-vivo singlechip executes the stimulation strategy. The singlechip in the body sends stimulation pulses to the photoelectrode array according to a stimulation strategy to activate the corresponding photoelectrode. The photoelectrode can activate or inhibit the irradiated nerve bundle with the expression of the optogenetic protein, thereby achieving the effect of nerve regulation.
The invention is further illustrated by the following specific example.
The in-vivo device and the photoelectrode array in this embodiment are shown in fig. 5, the photoelectrode array 1 includes a flexible shape memory fiber and a plurality of mini-LEDs, the flexibility of the flexible shape memory fiber can be adjusted according to the diameter of a nerve, the flexible shape memory fiber is wound around the nerve in a spiral cuff shape, 4-8 mini-LEDs are arranged on the inner surface of the spiral, and the mini-LEDs can emit light rays with different wavelengths. It can be easily found that the mini-LED array can be uniformly arranged at each position of the nerve bundle by twisting the flexible substrate on which the mini-LED array is arranged into the spiral sleeve in the embodiment. When a particular mini-LED is illuminated, the light emitted by the mini-LED will shine towards the nerve bundle at which it is aimed. When the optogenetic protein is expressed well in the nerve bundle, the illumination from the mini-LED will activate its neural activity. The mini-LED is connected with the in-vivo machine through a lead 2 and protected by an encapsulation coating.
The in-vivo machine in the embodiment comprises a packaging shell 3 and a receiving coil 4, wherein an in-vivo machine circuit board 5 is arranged in the packaging shell 3, an in-vivo singlechip 6, a carrier receiving circuit and a power circuit are arranged on the in-vivo machine circuit board 5, the carrier receiving circuit is connected with the receiving coil 4 through an input interface, and the receiving coil 4 is used for receiving energy and information sent by the in-vivo machine; the input end of the in-vivo singlechip 6 is connected with the carrier receiving circuit, and the output end of the in-vivo singlechip is connected with the photoelectrode array through an output interface, and is used for receiving the stimulation strategy and controlling the photoelectrode array according to the stimulation strategy; and the power supply circuit is connected with the carrier receiving circuit and used for supplying energy to the singlechip from the received energy. The coil packaging shell and the packaging shell in the embodiment both adopt M31CL waterproof resin, PDMS and other silicon medical packaging materials, and have good waterproofness and biocompatibility, so that the normal work of the implant can be ensured.
A photograph of an animal experiment in which the in vivo machine and the photoelectrode array are partially implanted into the cervical seven nerve roots of a mouse is shown in figure 6, an arc incision A is designed on the surface of the pectoralis major of the mouse, the in vivo machine is placed on the pectoralis major and the surface of the thoracic cavity on one side of the mouse, and the middle parts of the in vivo machine and a receiving coil are sutured and fixed with the chest wall muscle by 8-0prolene micro-suture. The photoelectrode array and the flexible shape memory fiber are wound around the root of the seven cervical nerves for a circle below the incision B of the pectoralis major, and the lead part is fixed at a plurality of positions by 8-0prolene micro suture to prevent the nerve from being damaged by the traction of the lead in the moving process of the mouse.
The flexible memory fiber and the photoelectrode array are wound on the mouse cervical seven nerve root in the animal experiment, the photograph is shown in fig. 7, the flexible spiral memory fiber surrounds the cervical seven nerve root for a circle, the internal machine part can be driven through the external machine transmitting coil, the mini-LED on the flexible spiral memory fiber is powered through the conducting wire, light with different wavelengths is emitted, and the blue light corresponding to the ChR2 optogenetic protein is emitted in the embodiment.
A photograph of an incision made in vivo after partial implantation in a mouse is shown in FIG. 8, where an arcuate incision A can be sutured by 8-0prolene micro-sutures without tension, and the body is located under the incision, pectoralis major and subcutaneous to the surface of the chest wall. The picture of the in vitro machine driving after the in vivo machine part is implanted into the mouse is shown in fig. 9, the in vivo machine part is implanted into the chest wall of the mouse and then the incision is sutured, the in vitro driver can drive the in vivo machine through skin, the mini-LED lights up to prompt the in vivo machine to work normally, the mini-LED on the photoelectrode array surrounding the cervical seven nerve roots can light up respectively to induce a plurality of different actions of the cervical seven innervation, such as the shoulder adduction, the wrist extension, the elbow extension and the like of the right forelimb of the transgenic Thy1-ChR2-eYFP mouse. The picture of the in vitro machine driving 20 days after the in vivo machine is partially implanted into the mouse is shown in fig. 10, the in vitro machine can still drive the in vivo machine to work through the skin of the mouse, and the fact that the in vivo machine of the implantation system can still work for a long time after being fully implanted under the skin of the mouse is prompted.
It is easy to find that the invention enables the patient to communicate and control the implant body through the external machine after the equipment is implanted through the design of the internal machine, the external machine and the photoelectrode array, thereby realizing accurate optogenetic stimulation in the rehabilitation course of treatment and carrying out targeted function rehabilitation. The whole system of the invention adopts a modular design, has the characteristics of miniaturization and portability, and enables a patient to start optogenetic nerve stimulation at any time and any place to promote nerve repair.
Claims (10)
1. The optogenetic peripheral nerve stimulation device is characterized by comprising an implant body and an extracorporeal machine, wherein the implant body comprises a photoelectrode array and the extracorporeal machine; the photoelectrode array is wrapped on the nerve bundle to be repaired and used for emitting light rays with different wavelengths to realize optogenetic stimulation on the nerve bundle to be repaired; the in-vivo machine is connected with the photoelectrode array, and the in-vivo machine are connected in a wireless communication mode; the in-vivo machine is used for supplying power to the in-vivo machine and sending out a stimulation strategy, and the in-vivo machine is used for controlling the photoelectrode array to work according to the stimulation strategy.
2. The optogenetic peripheral nerve stimulation device of claim 1, wherein the photoelectrode array comprises an elongated flexible substrate, a plurality of LEDs capable of emitting light of different wavelengths are arranged along a length direction of the elongated flexible substrate, the elongated flexible substrate is twisted into a helical cuff such that the LEDs are located inside the helical cuff, and the LEDs are connected to the internal device through wires.
3. The optogenetic peripheral nerve stimulation device of claim 2, wherein the stimulation strategy is an LED lighting time and position generated based on a rehabilitation evaluation result of the patient, the rehabilitation evaluation result including an evaluation result of a muscle function and an action of the patient and image information of the nerve bundle to be repaired, the LED lighting time is generated according to the evaluation result of the muscle function and the action of the patient, and the LED lighting position is generated according to the image information of the nerve bundle to be repaired; different muscle functions and actions correspond to the nerve branches in the nerve bundle to be repaired, and the light rays with different wavelengths correspond to the nerve branches in the nerve bundle to be repaired.
4. The optogenetic peripheral nerve stimulation device of claim 1, wherein the in vivo machine comprises an encapsulation housing and a receiving coil, wherein an in vivo machine circuit board is arranged in the encapsulation housing, an in vivo single chip microcomputer, a carrier receiving circuit and a power circuit are arranged on the in vivo machine circuit board, the carrier receiving circuit is connected with the receiving coil through an input interface, and the receiving coil is used for receiving energy and information sent by the in vivo machine; the input end of the in-vivo singlechip is connected with the carrier receiving circuit, and the output end of the in-vivo singlechip is connected with the photoelectrode array through an output interface, and the in-vivo singlechip is used for acquiring the stimulation strategy from the received information and controlling the photoelectrode array according to the stimulation strategy; and the power supply circuit is connected with the carrier receiving circuit and used for supplying energy to the singlechip from the received energy.
5. The optogenetic peripheral nerve stimulation device of claim 4, wherein the in vivo single chip microcomputer comprises a storage unit for storing the stimulation strategy, and the in vivo single chip microcomputer sends a control instruction to the photoelectrode array according to the stimulation strategy in the storage unit when a new stimulation strategy is not received.
6. The device for peripheral nerve stimulation according to claim 4, wherein the receiving coil is encapsulated in a coil encapsulating shell, a magnetic core is arranged in the middle of the receiving coil, and a magnetic shielding sheet is arranged between the receiving coil and the coil encapsulating shell.
7. The optogenetic peripheral nerve stimulation device of claim 1, wherein the extra-corporeal unit comprises a transmitting coil and an extra-corporeal circuit board, an extra-corporeal singlechip and a carrier transmitting circuit are arranged on the extra-corporeal unit circuit board and are connected with each other, the carrier transmitting circuit is connected with the transmitting coil through an interface, and the extra-corporeal singlechip transmits the stimulation strategy to the extra-corporeal unit through the carrier transmitting circuit and the transmitting coil.
8. The optogenetic peripheral nerve stimulation device of claim 6, wherein the external machine circuit board is further provided with a computer interface connected with the external singlechip.
9. The optogenetic peripheral nerve stimulation device of claim 6, wherein a power module for supplying power to the in vitro single chip microcomputer is further arranged on the in vitro machine circuit board.
10. An optogenetic peripheral nerve stimulation system, comprising the optogenetic peripheral nerve stimulation device according to any one of claims 1 to 9, a computer system and a direct current power supply, wherein the computer system and the direct current power supply are connected to the extracorporeal machine, and the computer system is configured to generate the stimulation strategy and transmit the stimulation strategy to the extracorporeal machine; the direct current power supply is used for supplying power to the external machine.
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| CN202310040381.5A CN115944858A (en) | 2023-01-12 | 2023-01-12 | Optogenetic peripheral nerve stimulation device and system |
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| CN202310040381.5A CN115944858A (en) | 2023-01-12 | 2023-01-12 | Optogenetic peripheral nerve stimulation device and system |
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