CN115944791A - Antibacterial metal base material, metal component and implantable medical device - Google Patents
Antibacterial metal base material, metal component and implantable medical device Download PDFInfo
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- CN115944791A CN115944791A CN202211345960.2A CN202211345960A CN115944791A CN 115944791 A CN115944791 A CN 115944791A CN 202211345960 A CN202211345960 A CN 202211345960A CN 115944791 A CN115944791 A CN 115944791A
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The present disclosure provides a metal substrate, a metal component and an implantable medical device having antibacterial properties. This metal substrate includes the metal base, first coating and second coating, the metal base has the texturing outer surface, first coating sets up in at least partly texturing outer surface, first coating includes insulating material, the second coating sets up in the surface of first coating, and the second coating includes degradable material and antibiotic medicine, in this application, the metal substrate can be processed into the medical component that can implant in vivo, utilize self coating to realize implantable medical device's antibacterial effect, thereby reduce the inflammatory response after implantable medical device implants, and reduce operation complexity and cost.
Description
Technical Field
The disclosure relates to the technical field of medical instruments, in particular to a metal base material with antibacterial property, a metal part and an implanted medical instrument.
Background
Implantable medical devices are medical devices that are implanted into a living body to treat diseases, and may be classified into active implantable medical devices and passive implantable medical devices. Active implantable medical devices are hermetically encapsulated electronic devices implanted in the human body, which infuse electrical pulses or drugs to a target location through a wire or catheter to achieve the purpose of treating or ameliorating symptoms. These electronic devices may be cardiac pacemakers, various neurostimulators (deep brain stimulator, vagus nerve stimulator, spinal cord stimulator, sacral nerve stimulator), drug infusion pumps, etc., and are generally hermetically encapsulated with a metal shell and provided with a channel connected to a lead or catheter.
In clinical practice, a certain proportion of patients will cause inflammatory reaction at the implanted part after the implantation of medical devices, especially in a period of time after the implantation operation is just completed, so that a new technical scheme is needed to solve the problem that the implanted medical devices frequently cause inflammatory reaction.
Disclosure of Invention
In order to reduce the inflammatory reaction of the implantable medical device after being implanted into the body and reduce the complexity and cost of the operation, the disclosure provides a metal base material with antibacterial property, a metal part and an implantable medical device.
In a first aspect, the present disclosure provides a metal substrate having antimicrobial properties, comprising:
a metal substrate having a textured outer surface;
a first coating disposed on at least a portion of the textured outer surface, the first coating comprising an insulating material; and
the second coating is arranged on the outer surface of the first coating and comprises a degradable material and an antibacterial drug.
In some alternative embodiments, the insulating material comprises at least one of parylene and polyurethane.
In some alternative embodiments, the antimicrobial drug comprises at least one of minocycline and rifampin.
In some alternative embodiments, the degradable material comprises at least one of collagen, cellulose, chitosan, polyester, polylactic acid and polyglycolic acid.
In some alternative embodiments, the outer surface of the first coating mirrors the surface structure of the textured outer surface, forming the outer surface of the textured first coating.
In some alternative embodiments, the outer surface of the second coating mirrors the surface structure of the outer surface of the first coating, forming a textured outer surface of the second coating.
A metal component for implantation within a living body, comprising:
a metal component body having a textured outer surface;
a first coating disposed on at least a portion of the textured outer surface, the first coating comprising an insulating material; and
the second coating is arranged on the outer surface of the first coating and comprises degradable materials and antibacterial drugs.
In some alternative embodiments, the insulating material comprises at least one of parylene and polyurethane.
In some alternative embodiments, the antibacterial drug comprises at least one of minocycline and rifampin.
In some alternative embodiments, the degradable material comprises at least one of collagen, cellulose, chitosan, polyester, polylactic acid and polyglycolic acid.
In some alternative embodiments, the outer surface of the first coating maps out the surface structure of the textured outer surface, forming the outer surface of the textured first coating.
In some alternative embodiments, the outer surface of the second coating maps out the surface structure of the outer surface of the first coating, forming a textured outer surface of the second coating.
In some alternative embodiments, the textured outer surface of the metal component body includes a first region and a second region;
the first region is provided with the first coating layer and the second coating layer, the second coating layer is positioned on the outer surface of the first coating layer, the first coating layer is used for insulation between the metal part body and a living body, and the second region is used for electric contact between the metal part body and the living body.
An implantable medical device comprises the metal component.
In some alternative embodiments, the implantable medical device comprises an implantable pulse generator, and the metal component comprises a housing component of the implantable pulse generator.
In some alternative embodiments, the implantable medical device includes an implantable electrode, and the metal component includes an electrode body of the implantable electrode.
According to the antibacterial metal base material, the metal part and the implantable medical device, the metal base body and the metal part body are provided with the textured outer surfaces, so that the metal base material and the metal part have long-acting antibacterial capacity, and the textured outer surfaces further enhance the binding property of the metal base body and the metal part body with the first coating respectively. The first coating improves the biocompatibility and basic antibacterial property of the metal matrix or the metal part body and the bonding property of the metal matrix or the metal part body and the second coating, the first coating comprises an insulating material and can realize the insulation between the metal part and an organism, when the coating is applied to an active implanted medical instrument, the first coating is selectively arranged on the surface of the instrument, the damage of current to human organs when a shell part of the implanted medical instrument stimulates or signals are collected can be avoided, the resistance of the first coating is increased relative to a plane on the textured outer surface, the service life of the first coating is prolonged, the second coating comprises a degradable material and an antibacterial drug, the drug can be slowly released when the second coating is degraded according to the designed slow release rate, the sterilization, antibacterial and bacteriostatic effects of one or more weeks are realized, the inflammatory reaction of the implanted medical instrument after being implanted into the body is reduced, and the complexity and the cost of an operation are reduced.
Drawings
Other features, objects and advantages of the present disclosure will become more apparent upon reading of the detailed description of non-limiting embodiments made with reference to the following drawings:
FIG. 1 is a schematic illustration of an implantable medical device for deep brain nerve stimulation;
FIG. 2 is a partial schematic view of a metal matrix according to an embodiment of the present disclosure;
FIG. 3 is a partial schematic view of a metal substrate provided with a first coating in accordance with an embodiment of the present disclosure;
4-5 are partial schematic views of a metal substrate according to embodiments of the present disclosure;
fig. 6 and 7 are schematic diagrams of a first embodiment of an implantable pulse generator according to the present disclosure;
fig. 8 is a schematic diagram of a second embodiment of an implantable pulse generator according to the present disclosure;
fig. 9 is a schematic diagram of a third embodiment of an implantable pulse generator according to the present disclosure.
Description of the symbols:
1. a top cover member; 2. a housing body; 3. coating; 31. a first coating layer; 32. a second coating layer; 4. a metal substrate; 41. texturing the outer surface;
601. a pulse generator; 602. an extension wire; 603. a joint; 604. an electrode fixing device; 605. an electrode; 606. a target point;
81. a top cover member; 82. a housing body; 821. an uncovered area; 83. coating; 831. an opening feature;
91. a top cover member; 92. a housing body; 921. an uncovered area; 93. coating; 931. an opening feature.
Detailed Description
The present disclosure is described in further detail below with reference to the accompanying drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the relevant invention and not restrictive of the invention. It should be noted that, for convenience of description, only the portions related to the present invention are shown in the drawings.
In the description of the present disclosure, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships and are only used for convenience in describing the present disclosure and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present disclosure. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present disclosure, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and the like are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; may be directly connected or indirectly connected through an intermediate. The specific meaning of the above terms in the present disclosure can be understood as a specific case by a person of ordinary skill in the art.
In the description of the present disclosure, it should be noted that the embodiments and features of the embodiments in the present disclosure may be combined with each other without conflict.
The implantable medical device shown in fig. 1 is used for deep brain nerve stimulation. As shown in FIG. 1, the implanted portion includes a pulse generator 601, an extension lead 602, a junction 603, an electrode fixture 604, and an electrode 605. The electrode fixture 604 secures the electrode 605 to the human head. The pulse generator 601 generates a stimulation signal that is transmitted through the extension lead 602 to the electrode 605, and the electrode 605 applies a stimulus to the target point 606 in accordance with the stimulation signal.
The implantable pulse generator 601 in fig. 1 includes a metal housing and a top cover made of a polymer material, and the electrode 605 includes a metal electrode body, which shows clinically that there is a phenomenon of capsular infection after a certain proportion of patients are implanted into the pulse generator, and there is also a phenomenon of brain tissue infection after a certain proportion of patients are implanted into the electrode. In this regard, the disclosed embodiments propose an antimicrobial solution to reduce the inflammatory response.
The embodiment of the present disclosure provides an antibacterial metal substrate, which includes a metal base 4, a first coating 31 and a second coating 32, wherein the metal base 4 has a textured outer surface 41, the first coating 31 is disposed on at least a portion of the textured outer surface 41, and the second coating 32 is disposed on an outer surface of the first coating 31.
In the embodiment of the present disclosure, the metal base 4 is, for example, a sheet or plate material used as a raw material. By surface-treating the metal base 4, a corresponding metal base material can be obtained. The metal substrate can be further used for manufacturing metal parts, such as a shell, an electrode and the like. It is understood that, when the metal base 4 is plate-shaped, the outer surface is the plate surface thereof, when the metal base 4 is column rib, the outer surface is the circumferential surface thereof, the outer surface may also include the surface which is located on the outermost side of the component in the use state after the component is processed, that is, an area which can be located on the outer side of the component is preset on the metal base 4 according to the structure of the component, the surface in the area can be defined as the outer surface, and the outer surface of the metal base 4 is textured to form the textured outer surface 41.
FIG. 2 is a partial schematic view of a metal matrix according to an embodiment of the disclosure. FIG. 3 is a partial schematic view of a metal substrate provided with a first coating in accordance with an embodiment of the present disclosure. 4-5 are partial schematic views of a metal substrate according to embodiments of the present disclosure;
the material of the metal matrix 4 in fig. 2 is, for example, titanium. The textured outer surface 41 may be formed by laser machining, micro-nano ultrasonic machining, electrochemical etching, surface ion sputtering, electrical discharge machining, or the like. The textured outer surface 41 may be micro-nano sized, for example, between 0.01 μm and 100 μm. The textured outer surface 41 may have a predetermined pattern and pattern depth.
As shown in fig. 3, the first coating 31 is made of an insulating polymer material, such as parylene, polyurethane, etc., and is formed on the textured outer surface 41 by means of pulling, chemical vapor deposition, sol-gel method, etc., the minimum thickness of the first coating 31 may be between 0.1 μm and 100 μm, and when the first coating 31 covers the textured outer surface 41 and the outer surface of the first coating 31 is planar, the thickness of the first coating 31 varies with the textured outer surface 41. Optionally, the thickness of the first coating 31 is adjustable, and the first coating 31 controllably maps the textured features of the metal substrate to form the textured outer surface of the first coating 31.
The second coating 32 is a degradable composite drug coating, and comprises a degradable high polymer material and an antibacterial drug. The degradable high molecular material is collagen, cellulose, chitosan, polyester, polylactic acid or polyglycolic acid, for example. The antibacterial agent is for example minocycline or rifampin. The degradable composite drug coating is prepared on the outer surface of the first coating 31 with a plane surface or textured characteristics by a dip coating method, a spraying method, a layer-by-layer self-assembly method, an electrostatic spinning method, a sol-gel method and the like, so as to form a second coating 32. The outer surface of the second coating 32 can be planar, the second coating 32 can overlay the textured features of the first coating 31 (see fig. 4), and the second coating 32 can also controllably map the textured features of the surface of the first coating 31 to form the outer surface of the textured second coating 32 (see fig. 5).
In the embodiment of the present disclosure, the surface of the metal substrate 4 is the textured outer surface 41, and the textured outer surface 41 can enhance the bonding strength with the first coating 31, increase the resistance of the first coating 31 to a certain extent, and improve the service life of the first coating. The first coating 31 has good biocompatibility, the first coating 31 maps the texturing characteristics of the metal matrix to form the outer surface of the textured first coating 31, so that the bacterial adhesion and proliferation of the outer surface of the first coating 31 can be reduced, the sterilization effect is improved, the infection risk is reduced, and the antibacterial effect of the combination of the high polymer material and the micro-texture is realized. The first coating 31 is made of insulating high polymer materials, when the metal base material is used for an active implantable medical device, the first coating 31 is selectively arranged on the metal base 4, so that the local insulation of parts of the implantable medical device can be realized, the damage to human organs caused by the current generated when electronic parts (such as a pulse generator) of the implantable medical device stimulate or signals are collected can be avoided, meanwhile, the first coating 31 can effectively isolate potential harmful microorganisms from the medical device, body fluid, moisture and chemical medicines can be efficiently separated, the body of a patient can be protected from the release of harmful substances contained in metal and plastic, and the medical device can be protected from the permeation of the body fluid of the human body.
The first coating 31 is preferably parylene, which has good biocompatibility, antimicrobial properties, reduced friction and enhanced bonding of the metal matrix 4 to the second coating 32.
The second coating 32 can slowly release the drug according to the designed slow release rate, so that the antibacterial effect of one week or several weeks is realized, the degradable high polymer material is gradually degraded in the implantation environment, the first coating 31 is exposed, the bacteria adsorption of the first coating can be reduced, the basic antibacterial performance is improved, the outer surface of the textured first coating 31 can play a continuous antibacterial effect, and the stable and controllable antibacterial effect is realized.
The invention integrates the physicochemical properties of a micro-nano structure and a high polymer material, combines the parylene and the micro-texture, regulates the topological structure and the hydrophilicity and hydrophobicity of the metal surface, realizes long-acting antibiosis and local insulation of the metal (titanium) surface, adopts a degradable drug-loaded coating on the outermost layer, and realizes short-term strong antibiosis, sterilization and bacteriostasis. The metal base material is used for the implantable medical device, and the antibacterial effect of the device can be improved, so that the inflammatory reaction of the implantable medical device after implantation is reduced, and the complexity and cost of the operation are reduced.
The disclosed embodiments also provide a metal part that includes a metal part body having a textured outer surface 41. Referring to fig. 2-5, at least a portion of the textured outer surface 41 is provided with the first and second coatings 31, 32 as previously described.
The metal member body is, for example, a metal main body portion of the metal member, and corresponds to a state after the metal material molding process and before the surface treatment. By surface-treating the metal member body, a corresponding metal member can be obtained. Illustratively, the metal stock material may be processed into a shell-like or other desired shape as the metal component body by a forming process such as stamping, forging, casting, cutting, or the like. And texturing the outer surface of the metal member body to form a textured outer surface 41, and providing a coating on at least a portion of the textured outer surface 41 to form the metal member. In this application, the outer surface of the metal member body refers to a surface exposed to the outside (a surface of the metal member which is used to be in direct contact with a human body after being implanted into the body) after being processed into a shell shape or other desired shape, and a surface which is located inside the shell or inside the other-shaped member and is not exposed is referred to as an inner surface, and the outer surface of the metal member body is textured to form a textured outer surface 41.
In some examples, the textured outer surface 41 of the metal component body includes a first region and a second region; the first region is provided with a first coating 31 and a second coating 32, the second coating 32 being located on the outer surface of the first coating 31, the first coating 32 serving as insulation between the metal member body and the living body, and the second region serving as an electrical contact region between the metal member body and the living body. Specifically, when the metal component is used as a component of an implantable medical device (such as a shell component of a pulse generator), the area of the metal component body, which is used for being in contact with a human organ, is defined as a first area, and a first coating 31 is arranged in the first area, so that the local insulation of the metal component is realized, and the damage of the current generated when the pulse generator stimulates or collects signals on the human organ is avoided.
The first coating 31 is made of insulating high polymer materials such as parylene and polyurethane, the first coating 31 has good biocompatibility, the first coating 31 is mapped to the texturing feature of the metal part body, the outer surface of the textured first coating 31 is formed, bacteria adsorption can be reduced, the sterilization effect is improved, the infection texturing risk is reduced, and the high polymer materials and the micro-structure are combined to resist bacteria. The first coating 31 can also effectively isolate potentially harmful microorganisms from the medical device, can efficiently block body fluids, moisture and chemicals, and can protect the body of a patient from the release of harmful substances contained in metals and plastics and also protect the medical device from the penetration of body fluids of the human body. The second coating layer 32 includes a degradable polymer material such as collagen, cellulose, chitosan, polyester, polylactic acid or polyglycolic acid, and an antibacterial drug such as minocycline or rifampin. According to the slow release rate of design slowly-releasing medicine, realize antibiotic, antibacterial and bactericidal action for a week or several weeks, degradable macromolecular material degrades gradually in implanting the environment, exposes first coating 31, and the reducible bacterial adsorption of first coating 31 of high-molecular material, the surface of textured first coating 31 has antibacterial effect, can play and last antibacterial action to realize stable and controllable antibacterial effect.
The application also provides an implantable medical device, which can be a deep brain stimulator, a vagus nerve stimulator, a spinal cord stimulator or a sacral nerve stimulator, and the implantable medical device comprises a pulse generator, wherein the pulse generator is provided with the metal component, and the metal component comprises a shell component of the pulse generator.
Fig. 6 and 7 are schematic diagrams of a first embodiment of an implantable pulse generator according to the present disclosure. As shown in fig. 6 and 7, the implantable pulse generator includes a cap member 1 and a housing member including a housing body 2 (i.e., a metal member body) and a coating layer 3. The coating 3 is provided on the outside of the case body 2. The outer side surface of the housing body 2 is machined to the textured outer surface 41 as described above, and the coating 3 may be a coating in different states as shown in fig. 3 to 5. As shown in fig. 3, the coating 3 only includes a first coating, and the first coating 31 is mapped on the textured outer surface 41 of the shell body 2 and combined with the textured structure through a polymer material for antibiosis; or, as shown in fig. 4, the coating 3 includes a first coating 31 and a second coating 32, the first coating 31 is mapped on the textured outer surface 41 of the shell body 2, and the outer surface of the second coating 32 is a plane, so as to realize drug antibiosis, high molecular material and textured structure combination antibiosis; alternatively, as shown in fig. 5, the coating 3 includes a first coating 31 and a second coating 32, the first coating 31 is mapped to the textured outer surface 41 of the shell body 2, and the second coating 32 is mapped to the textured surface formed by the first coating 31, so that the second coating 32 can be both pharmaceutically antibacterial and textured antibacterial.
Fig. 8 is a schematic diagram of a second embodiment of an implantable pulse generator according to the present disclosure. As shown in fig. 8, the implantable pulse generator has a cap member 81 and a housing member, which includes a housing body 82 (i.e., a metal member body) and a coating 83. The coating 83 is arranged on the outer side wall of the shell body 82, the coating 83 is provided with an opening feature 831, the opening feature 831 is close to the middle area of the shell component, and the shape of the opening feature 831 can be set according to requirements. The housing body at the opening feature 831 is exposed and can serve as a contact for stimulation or signal acquisition. The textured outer surface 41 is processed on the outer side surface of the shell body 82, which is in contact with the coating 83, and the coating 83 can be coatings in different states as shown in fig. 3-5, that is, the coating 83 can only comprise the first coating 31, the first and second coatings 32, the first coating 31 and the second coating 32, and the outer surface of the second coating 32 is textured, and the first coating 31 realizes local insulation of the shell component, so that the pulse generator is prevented from damaging human organs through current generated when the shell component stimulates or collects signals. The area within the opening feature 831 is an uncovered area 821, and it will be appreciated that the second area includes the uncovered area 821 within the opening feature 831, and the uncovered area 821 of the housing body 82 may be a surface formed by a general process or a textured surface, and the textured surface may serve to enhance the antibacterial effect of the housing component, enhance the charge infusion capability, and the like.
Fig. 9 is a schematic diagram of a third embodiment of an implantable pulse generator according to the present disclosure. As shown in fig. 9, the implantable pulse generator has a cap member 91 and a housing member including a housing body 92 (i.e., a metal member body) and a coating 93. The coating 93 is provided on the outer side wall of the case body 92, the coating 93 is provided with a plurality of opening features 931 to form multipoint contact with the human body, and the opening features 931 may be circular, square, or other irregular shapes thereof. The area within the opening feature 931 is the uncovered area 921, and the housing body at the uncovered area 921 is exposed and can be used as a contact for stimulation or signal acquisition. The outer surface of the housing body 92 outside the region in contact with the coating 93 is textured, and the coating 93 can be a coating in different states as shown in fig. 3-5, i.e., the coating 93 can comprise only the first coating 31, comprise the first coating 31 and the second coating 32, and have the outer surface of the second coating 32 textured. The shell body 92 in the uncovered area 921 may be a surface formed by a general process or a textured surface that may function to enhance the antimicrobial effect, enhance the charge infusion capability, and the like.
The implantable medical device in this embodiment has similar technical effects to the coating 3, and will not be described herein again.
In some embodiments, the implantable medical device includes an implantable electrode, and the metal component may be an electrode body of the implantable electrode. One end of the electrode body is connected with a lead, and the other end of the electrode body is a free end. One side of the free end of the electrode body is provided with a plurality of electrical stimulation areas, and the rest areas are insulation areas. The surface of the metal substrate corresponding to the insulating region of the electrode body is provided with the first coating 31 and the second coating 32.
In some embodiments, the implantable medical device may also be an implantable cardiac pacemaker or implantable drug pump, and the parts (e.g., housing parts) that contact the human body may be replaced with the above-described metal parts to reduce the inflammatory response after implantation in the human body.
The metal surface antibacterial effect is realized by combining the textured outer surface, the insulating coating and the degradable drug coating, and the metal surface antibacterial effect can be applied to metal substrates, formed metal parts or implantable medical devices. Taking the housing component of the implantable pulse generator as an example: the first coating 31 and the second coating 32 are arranged on at least one part of the textured outer surface 41 of the shell component, and the textured outer surface 41 enables the shell component to have long-acting antibacterial capacity, improves the charge infusion capacity of the shell component, can also enhance the bonding strength of the shell component and the first coating 31, and also increases the resistance of the first coating 31 to a certain extent and prolongs the service life of the shell component. The first coating 31 is made of an insulating high polymer material, so that the shell component and the human organ can be insulated, preferably parylene, the first coating 31 has good biocompatibility, the basic antibacterial capacity is improved, the friction between the shell component and the human body is reduced, and the binding property between the shell component and the second coating 32 is improved, the surface of the first coating 31 is microtextured, or the first coating 31 is mapped on the textured outer surface 41 of the shell component, so that the combined antibacterial effect of parylene and microtexture can be realized, and the shell component has long-acting antibacterial capacity. The second coating 32 is a degradable composite drug coating, the drug is slowly released in the degradation process, the antibacterial, bacteriostatic and bactericidal effects within one or more weeks are realized, and the second coating 32 is mapped on the first coating 31 to form a textured surface, so that the bacteria can be further inhibited.
It can be understood that the application carries out antibacterial design based on the recovery state of the human wound, the requirement of the early stage of wound recovery mainly lies in antibacterial strength, and the second coating 32 is decomposed to release the medicament, so that the medicament can carry out strong antibacterial effect, and the infection risk is reduced; after one or more weeks, the second coating 32 is degraded, the wound tends to be stable, the requirement of wound recovery at this time is mainly that the antibacterial duration is long, the first coating 31 is combined with the microtexture to realize long-acting antibacterial and reduce the risk of wound inflammation, and the first coating 31 made of the insulating material can also prevent the injury of the human organs caused by the current generated when the implanted electronic component stimulates or the signal is collected.
The foregoing description is only exemplary of the preferred embodiments of the disclosure and is illustrative of the principles of the technology employed. It will be appreciated by those skilled in the art that the scope of the invention in the present disclosure is not limited to the specific combination of the above-mentioned features, but also encompasses other embodiments in which any combination of the above-mentioned features or their equivalents is possible without departing from the inventive concept as defined above. For example, the above features and (but not limited to) the features disclosed in this disclosure having similar functions are replaced with each other to form the technical solution.
Claims (10)
1. A metal base material having antibacterial properties, comprising:
a metal substrate having a textured outer surface;
a first coating disposed on at least a portion of the textured outer surface, the first coating comprising an insulating material; and
the second coating is arranged on the outer surface of the first coating and comprises degradable materials and antibacterial drugs.
2. The metal substrate of claim 1, wherein the outer surface of the first coating layer mirrors the surface structure of the textured outer surface, forming the outer surface of the textured first coating layer.
3. The metal substrate of claim 2, wherein the outer surface of the second coating layer mirrors the surface texture of the outer surface of the first coating layer, forming a textured outer surface of the second coating layer.
4. A metal component for implantation in a living body, comprising:
a metal component body having a textured outer surface;
a first coating disposed on at least a portion of the textured outer surface, the first coating comprising an insulating material; and
the second coating is arranged on the outer surface of the first coating and comprises a degradable material and an antibacterial drug.
5. The metal component of claim 4, wherein the outer surface of the first coating layer mirrors the surface structure of the textured outer surface, forming the outer surface of the textured first coating layer.
6. The metal part of claim 5, wherein the outer surface of the second coating maps out the surface texture of the outer surface of the first coating, forming a textured outer surface of the second coating.
7. The metal component of claim 4, wherein the textured outer surface of the metal component body comprises a first region and a second region;
the first region is provided with the first coating and the second coating, the second coating is positioned on the outer surface of the first coating, the first coating is used for insulation between the metal part body and a living body, and the second region is used for electric contact between the metal part body and the living body.
8. An implantable medical device, characterized in that it comprises a metal part according to any one of claims 4 to 7.
9. The implantable medical device of claim 8, wherein the implantable medical device comprises an implantable pulse generator, and wherein the metallic component comprises a housing component of the implantable pulse generator.
10. The implantable medical device of claim 9, wherein the implantable medical device comprises an implantable electrode, and wherein the metallic component comprises an electrode body of the implantable electrode.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211345960.2A CN115944791A (en) | 2022-10-31 | 2022-10-31 | Antibacterial metal base material, metal component and implantable medical device |
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| CN202211345960.2A CN115944791A (en) | 2022-10-31 | 2022-10-31 | Antibacterial metal base material, metal component and implantable medical device |
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| CN202211345960.2A Pending CN115944791A (en) | 2022-10-31 | 2022-10-31 | Antibacterial metal base material, metal component and implantable medical device |
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| CN (1) | CN115944791A (en) |
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