CN115919682A - Coated supermolecule oil-control antibacterial composition, preparation method and application thereof - Google Patents
Coated supermolecule oil-control antibacterial composition, preparation method and application thereof Download PDFInfo
- Publication number
- CN115919682A CN115919682A CN202211457975.8A CN202211457975A CN115919682A CN 115919682 A CN115919682 A CN 115919682A CN 202211457975 A CN202211457975 A CN 202211457975A CN 115919682 A CN115919682 A CN 115919682A
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- CN
- China
- Prior art keywords
- oil
- cyclodextrin
- acid
- supermolecule
- organic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a coated supermolecule oil-control bacteriostatic composition, a preparation method and application thereof. The supermolecule-wrapped oil-control bacteriostatic composition consists of organic acid, basic amino acid and cyclodextrin, wherein the organic acid is selected from one or more of salicylic acid, caprylyl glycine, azelaic acid and succinic acid, the organic acid and the basic amino acid are combined into the supermolecule organic acid through hydrogen bond connection, and the composition contains a cyclodextrin inclusion compound formed by wrapping organic acid supermolecules with the cyclodextrin. The oil-control bacteriostatic composition disclosed by the invention wraps organic acid supermolecules through cyclodextrin molecules, and has the advantages of good water solubility, low irritation, easiness in compatibility, high bioavailability, difficulty in separation of active components and the like. The combination of the organic acid can also generate a synergistic effect, and the oil control and bacteriostasis effects are better.
Description
Technical Field
The invention belongs to the technical field of cosmetics, relates to a cosmetic intermediate component with oil control and bacteriostasis functions, and particularly relates to a coated supermolecule oil control and bacteriostasis composition as well as a preparation method and application thereof.
Background
Various active substances or functional additives are often added into cosmetics to achieve better effects. For example, anti-dandruff agents are often added to hair shampoo products. Dandruff formation is associated with seborrheic dermatitis of the scalp, which is caused by an excessive proliferation of malassezia furfur, a dermatophyte. Literature data show that malassezia and scalp lipids are essential factors for dandruff production. The hair oil and malassezia are the root causes of scalp problems, so that the oil-controlling and bacteriostatic components added into the shampoo product can achieve better dandruff-removing effect.
Caprylyl glycine, azelaic acid, succinic acid, salicylic acid and the like are common additive components in cosmetics and have the effects of regulating skin, sterilizing, inhibiting bacteria and the like. For example, succinic acid is a good surfactant, and also has antibacterial effect, and has inhibitory effect on Staphylococcus aureus, catalpus, etc., and can be used as pH regulator, surfactant, antioxidant, astringent, antibacterial agent, etc. in cosmetics.
Capryloyl glycine is the major component of dermal structural proteins, and one of the important functions is to balance the pH of the skin. The pH of the skin is around 5.5 because of the presence of various weak acids, proteins and fats. When the different components react with the skin's fatty proteins, these proteins undergo decarboxylation reactions, thereby changing the skin pH. Neither too high nor too low a pH is good, especially for pox skins. Many studies have shown that: the skin pH of the pox muscle is high. The presence of capryloyl glycine can provide free carboxyl groups, maintaining the balance of skin pH. Caprylyl glycine can also be used as a conditioner, a foaming agent and the like in cosmetics, has good affinity with skin, and can also effectively convey other components, so that the using effect of products with other effects can be improved. Meanwhile, caprylyl glycine has certain effects on effectively inhibiting the activation of elastase, preventing the decomposition of elastin, reducing skin wrinkles, regulating the self-repair of skin and the like. In addition, the capryloyl glycine has a good bacteriostatic effect, has a strong inhibiting effect on staphylococcus aureus, propionibacterium acnes and the like, can resist excessive sebum secretion, and has a relatively obvious effect on preventing and treating acnes. However, caprylyl glycine is a fat-soluble substance, and is added into an aqueous system to be dissolved and dispersed by a solubilizer or a surfactant, so that the application of caprylyl glycine is limited in some aqueous systems.
Azelaic acid (also known as azelaic acid) has antibacterial effect and can be used as food antiseptic; can directly inhibit and kill bacteria on skin surface and in hair follicle, and eliminate pathogen. Azelaic acid is also known as a compound for regulating the secretion of skin oil, is used in hair care products together with vitamin B6, is suitable for treating male hormone alopecia with vigorous internal secretion in males, and simultaneously stimulates the growth of hair. However, azelaic acid is substantially insoluble in water and is difficult to be incorporated directly into cosmetics. Disodium or dipotassium salts thereof are often used in cosmetic formulations, but affect their physiological activity or functionality.
Salicylic acid has effects of regulating cutin, dredging pores, shrinking pores, controlling oil, resisting inflammation, etc., and can be widely used in cosmetics. The salicylic acid has the solubility of 2g/L in water at 20 ℃, is almost insoluble in water, is easy to generate crystal precipitation when being directly added into a formula of a skin care product, and reduces the bioavailability of the salicylic acid. Salicylic acid itself is poorly water-soluble and emits strong pungent odor, and is often made into supramolecular preparations in practical use to enhance water solubility. The method for solving the application problem of salicylic acid in cosmetics also comprises chemical modification, lipidization, microencapsulation and the like. Salicylic acid derivatives include betaine salicylate, octanoyl salicylic acid, tridecyl alcohol salicylate, etc., and such substances obtained by chemical modification improve the solubility or irritation to some extent, but do not substantially solve the problems.
In order to ensure the stability of the product and avoid crystallization of caprylyl glycine, salicylic acid and the like, a large amount of solvent is usually used in practical application, for example, after the caprylyl glycine, salicylic acid and the like are dissolved in alcohol, a large amount of surfactant is added to help the caprylyl glycine, salicylic acid and the like to be dissolved in water. However, high levels of alcohol and surfactants in cosmetics can cause irritation to the skin, scalp, etc., and consumers dislike cosmetics containing high levels of alcohol, thus limiting their addition to formulations in sufficient amounts, resulting in products that are not as effective.
Disclosure of Invention
The invention aims to provide a coated supermolecule oil-controlling and bacteriostatic composition and a preparation method thereof, aiming at the defects and defects of the prior art, the coated supermolecule oil-controlling and bacteriostatic composition has oil-controlling and bacteriostatic effects, good water solubility, low irritation and good bioavailability, is used as a cosmetic intermediate component, is greatly improved in solubility, permeability, irritation and stability, and is convenient to add and apply.
The invention also aims to provide a cosmetic intermediate with oil control and bacteriostasis functions.
The invention also aims to provide an application of the wrapped supermolecule oil-control bacteriostatic composition in cosmetics.
In order to achieve the purpose, the invention adopts the following technical scheme:
a supermolecule-wrapped oil-control bacteriostatic composition consists of organic acid, basic amino acid and cyclodextrin, wherein the organic acid is selected from one or more of salicylic acid, caprylyl glycine, azelaic acid and succinic acid, the organic acid and the basic amino acid are connected and combined into the supermolecule organic acid through hydrogen bonds, and the composition contains a cyclodextrin inclusion compound formed by wrapping supermolecule of the organic acid with the cyclodextrin.
Inclusion compounds (inclusions) are inclusions of one species of molecule (active) embedded in a cavity structure of another species of molecule (constituent), also known as "molecular capsules". Among them, an inclusion molecule having a cavity structure is referred to as a host molecule, and an embedded molecule is referred to as a guest molecule. The oil-controlling bacteriostatic composition is a cyclodextrin inclusion compound mainly using cyclodextrin as a main molecule, wherein a guest molecule is a supermolecule organic acid consisting of organic acid such as caprylyl glycine and the like and basic amino acid. The cyclodextrin inclusion compound consists of a host molecule, namely cyclodextrin, and a guest molecule, namely supramolecular organic acid, wrapped in the host molecule, or is called as wrapped supramolecular organic acid. The supramolecular organic acid is embedded into the inner cavity of the cyclodextrin through molecular wrapping to form the oil-control bacteriostatic composition wrapped in the form of the supramolecular organic acid.
Further, the mass ratio of the organic acid to the basic amino acid is 1-10, preferably 1:5-5:1, and more preferably 1:3-3:1.
Wherein the mass ratio of the supramolecular organic acid to the cyclodextrin is 1-20, the preferable ratio is 1.
Preferably, in the coated supramolecular oil-controlling and bacteriostatic composition, the organic acid is selected from salicylic acid and caprylyl glycine, wherein the mass ratio of the salicylic acid to the caprylyl glycine is 1:10-10:1. the pH value of the supermolecule-wrapped organic acid solution of salicylic acid and caprylyl glycine is 3-7, the preferable pH value range is 3.5-6.5, and the more preferable pH value range is 4.0-6.0.
In the wrapped supermolecule oil-controlling bacteriostatic composition, the main molecule cyclodextrin is alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin or derivatives thereof, preferably one or a combination of more than two of beta-cyclodextrin, gamma-cyclodextrin, hydroxyethyl-beta-cyclodextrin, hydroxypropyl-beta-cyclodextrin, dihydroxypropyl-beta-cyclodextrin, methyl-beta-cyclodextrin, glucose cyclodextrin, maltose cyclodextrin or carboxymethyl cyclodextrin.
In the wrapped supermolecule oil-control bacteriostatic composition, a guest molecule is supermolecule organic acid consisting of organic acid and basic amino acid, and the organic acid and the basic amino acid are connected through a carboxyl group of the organic acid and an amino group of the basic amino acid through a hydrogen bond to form the supermolecule organic acid. Wherein the basic amino acid is selected from arginine, histidine or lysine, or one or more of their derivatives, or plant extract amino acids containing the basic amino acids, including sesame amino acid, apple amino acid, corn amino acid, wheat amino acid or other plant amino acids.
The preparation method of the supermolecule-wrapped oil-control bacteriostatic composition comprises the following steps: adding basic amino acid, organic acid and cyclodextrin into water to form a mixed solution, stirring until the mixed solution is transparent and uniform to obtain a supramolecular-wrapped organic acid aqueous solution, and drying and dehydrating the aqueous solution to obtain the supramolecular-wrapped oil-control antibacterial composition.
Further, the mixture is kept at a certain temperature, such as 30-80 ℃ under stirring, preferably 40-70 ℃, more preferably 50-60 ℃.
Further, a spray drying method is adopted for drying and dehydrating, and the powder of the oil-controlling bacteriostatic composition can be obtained after the aqueous solution is dried and dehydrated. Preferably, the water content of the obtained powder is controlled to be lower than 5%.
According to the preparation method, the powder wrapping the supermolecule oil-control antibacterial composition can be obtained after dehydration. The supermolecule-wrapped oil-controlling bacteriostatic composition can be prepared into an aqueous solution in practical application, and the step of drying and dehydration can be omitted. Further, in the above preparation method, the solid-to-liquid ratio of the mixed solution can be controlled, for example, the ratio of the solid to the water is 10:90-90:10, preferably in a ratio of 50:50-80:20, more preferably in a ratio of 60:40-70:30, preparing the supermolecule-wrapped organic acid aqueous solution.
Based on the oil-control bacteriostatic composition, whether powder or aqueous solution thereof, a cosmetic intermediate with oil-control bacteriostatic effect can be obtained, wherein the coated supermolecule oil-control bacteriostatic composition is contained.
The cosmetic intermediate may further comprise a chelating agent and/or an antioxidant. The chelating agent includes but is not limited to tetrasodium glutamate diacetate, trisodium dihydroxymethyl alanine, EDTA2Na, EDTA4Na and the like; the antioxidant includes, but is not limited to, sodium bisulfite, sodium metabisulfite, ve acetate and the like.
The invention also relates to application of the coated supermolecule oil-control antibacterial composition in cosmetics. The coated supermolecule oil-controlling bacteriostatic composition can be used for personal washing and care products, including but not limited to shampoos, hair conditioners, cleansing products, bath products and hand washing products; it can also be used in skin care products, skin caring products, makeup removing products, sunscreen products, etc. The product dosage forms employed include, but are not limited to, aqueous solutions, emulsions, creams, powders, sprays, foams, and the like.
The supermolecule-wrapped oil-controlling bacteriostatic composition has good water solubility, low irritation and easy compatibility, and completely keeps the activity or the efficacy of functional components in the composition, and the composition shows better oil-controlling and bacteriostatic effects due to the synergistic interaction between the compound components. The composition can be used in cosmetics without the assistance of a large amount of organic solvents and surfactants, particularly meets the later-stage application of cosmetics and personal care products, and has the advantages of high bioavailability, difficult precipitation and crystallization of organic acid of the later-stage products and the like.
Has the beneficial effects that: the invention utilizes the molecular characteristic that cyclodextrin molecules have ring-shaped cavities, can form a cyclodextrin inclusion compound with supermolecule organic acid, and a main molecule has a larger cavity structure, so that guest molecules, namely supermolecule organic acid formed by basic amino acid and specific organic acid, can be contained to form a molecular capsule. By the molecular wrapping, the supermolecule organic acid has the advantages of better water solubility, low irritation, higher bioavailability and the like, and can improve the inhibition rate of organic acids such as caprylyl glycine, salicylic acid and the like on harmful bacteria such as acne bacillus, malassezia and the like, and improve the effects of caprylyl glycine, salicylic acid and the like on the problems of excessive secretion of acne, dandruff, grease and the like. The organic acid caprylyl glycine, salicylic acid and the like can play a role in synergy through compounding, and have better oil control and bacteriostatic effects.
Drawings
FIG. 1 shows dark field photographs under a polarizing microscope of a wrapped supramolecular oil-controlling bacteriostatic composition (left) and unwrapped salicylic acid supramolecules (right);
fig. 2 shows the bacteriostatic effect of the transparent shampoo containing different oil-control bacteriostatic components on malassezia furfur (1.
Detailed Description
Example 1
The supermolecule wrapped oil-control bacteriostatic composition is a cyclodextrin inclusion compound and consists of the following components in parts by weight: 24 parts of salicylic acid, 6 parts of caprylyl glycine, 15 parts of arginine, 15 parts of histidine and 40 parts of hydroxypropyl beta-cyclodextrin.
The cyclodextrin inclusion compound consists of a host molecule and a guest molecule included in the host molecule, wherein the host molecule is a hydroxypropyl beta-cyclodextrin compound, and the guest molecule is supermolecule salicylic acid/supermolecule caprylyl glycine consisting of salicylic acid, caprylyl glycine, arginine and histidine.
The preparation method comprises the following steps: mixing and stirring 15 parts of histidine, 15 parts of arginine, 40 parts of hydroxypropyl beta-cyclodextrin, 24 parts of salicylic acid and 6 parts of caprylyl glycine in water, keeping the temperature at 65 ℃, and stirring until the solid is completely dissolved to obtain a transparent solution, wherein the ratio of the solid matter to the water is 2:1; and then the water solution is subjected to spray drying to remove water to obtain powder, the water content of the obtained powder is controlled to be lower than 5%, and the supermolecule salicylic acid/capryloyl glycine coated oil-control antibacterial composition is obtained. The pH value of a 10% aqueous solution wrapping the supermolecule salicylic acid/caprylyl glycine oil-controlling and bacteriostasis composition is 5.0.
The obtained solid is not in a crystalline form when wrapping the supermolecule oil-control bacteriostatic composition in appearance, and is close to a glassy state appearance; the dark field under the polarization microscope is in an amorphous state (figure 1), belongs to the characteristic of an isotropic structure, and is in an amorphous structure. The appearance of the non-coated salicylic acid, the caprylyl glycine or the supramolecules of the salicylic acid and the caprylyl glycine has crystallinity, and the crystal form can be seen under a polarizing microscope dark field and is characterized by an anisotropic crystal structure.
Example 2
The supermolecule wrapped oil-control bacteriostatic composition is a cyclodextrin inclusion compound and consists of the following components in parts by weight: 30 parts of salicylic acid, 20 parts of caprylyl glycine, 30 parts of histidine and 20 parts of gamma-cyclodextrin.
The cyclodextrin inclusion compound consists of a main molecule and guest molecules included in the main molecule, wherein the main molecule is gamma-cyclodextrin, and the guest molecules are supermolecule organic acid consisting of salicylic acid, caprylyl glycine and histidine.
The preparation method comprises the following steps: a mixture of 30 parts histidine, 20 parts caprylylglycine, 30 parts salicylic acid, 20 parts gamma-cyclodextrin was stirred in water, maintaining 60 ℃, stirring was continued until a clear solution was obtained. The ratio of solids to water was 1:1. and drying the aqueous solution to remove water to obtain powder. Controlling the water content of the obtained powder to be lower than 5 percent. The wrapped supermolecule oil-controlling and bacteria-inhibiting agent is obtained. The pH of the resulting 10% solution of wrapped supramolecular salicylic acid was 5.8.
Example 3
The supermolecule wrapped oil-control bacteriostatic composition is a cyclodextrin inclusion compound and consists of the following components in parts by weight: 40 parts of salicylic acid, 5 parts of caprylyl glycine, 15 parts of lysine, 25 parts of arginine and 15 parts of hydroxypropyl beta-cyclodextrin.
The cyclodextrin inclusion compound consists of a host molecule and a guest molecule included in the host molecule, wherein the host molecule is hydroxypropyl beta-cyclodextrin, and the guest molecule is supermolecule organic acid formed by salicylic acid, caprylyl glycine, lysine and arginine.
The preparation method comprises the following steps: and (2) stirring and dissolving a mixture of 15 parts of lysine, 25 parts of arginine, 15 parts of hydroxypropyl beta-cyclodextrin, 40 parts of salicylic acid and 5 parts of caprylyl glycine in 50 parts of water, keeping the temperature at 70 ℃, and stirring until the solid is completely dissolved to obtain a transparent and uniform solution, namely the aqueous solution wrapping the supermolecule oil-controlling antibacterial composition. The pH of the aqueous solution was 5.1.
Example 4
The supermolecule wrapped oil-control bacteriostatic composition is a cyclodextrin inclusion compound and consists of the following components in parts by weight: 20 parts of salicylic acid, 20 parts of azelaic acid, 10 parts of caprylyl glycine, 30 parts of arginine and 20 parts of hydroxypropyl beta-cyclodextrin.
The cyclodextrin inclusion compound consists of a host molecule and a guest molecule included in the host molecule, wherein the host molecule is hydroxypropyl beta-cyclodextrin, and the guest molecule is supermolecule organic acid consisting of salicylic acid, azelaic acid, caprylyl glycine and arginine.
The preparation method comprises the following steps: stirring a mixture of 30 parts of arginine, 20 parts of hydroxypropyl beta-cyclodextrin, 20 parts of salicylic acid, 20 parts of azelaic acid and 10 parts of caprylyl glycine in water, keeping the temperature at 70 ℃, stirring until the solid is completely dissolved to obtain a transparent uniform solution, performing spray drying on the aqueous solution to obtain powder, and controlling the water content of the obtained powder to be lower than 5%, thereby obtaining the oil-controlling and antibacterial composition wrapping the supermolecule salicylic acid, the supermolecule azelaic acid and the supermolecule caprylyl glycine. The pH value of a 10% aqueous solution wrapping the supermolecule oil-controlling bacteriostatic composition is 5.2.
Example 5
The supermolecule wrapped oil-control bacteriostatic composition is a cyclodextrin inclusion compound and consists of the following components in parts by weight: the cyclodextrin inclusion compound comprises a main molecule and a guest molecule included in the main molecule, wherein the main molecule is hydroxypropyl gamma-cyclodextrin, and the guest molecule is supramolecular succinic acid formed by succinic acid, lysine and arginine.
The preparation method comprises the following steps: stirring a mixture of 45 parts of arginine, 20 parts of hydroxypropyl gamma-cyclodextrin and 35 parts of succinic acid in water, keeping the temperature at 70 ℃, stirring until the solid is completely dissolved to obtain a transparent and uniform solution, then carrying out spray drying on the solution to obtain powder, and controlling the water content of the obtained powder to be lower than 5% to obtain the supermolecule succinic acid-coated oil-controlling antibacterial composition. The pH value of a 10% aqueous solution wrapping the supermolecule succinic acid oil-controlling bacteriostatic composition is 5.0.
Example 6
The supermolecule-wrapped oil-controlling bacteriostatic composition is a cyclodextrin inclusion compound and consists of the following components in parts by weight: the cyclodextrin inclusion compound comprises a main molecule and guest molecules included in the main molecule, wherein the main molecule is hydroxypropyl gamma-cyclodextrin, and the guest molecules are supramolecular salicylic acid formed by salicylic acid and histidine.
The preparation method comprises the following steps: stirring a mixture of 45 parts of histidine, 15 parts of hydroxypropyl gamma-cyclodextrin and 40 parts of salicylic acid in water, keeping the temperature at 60 ℃, stirring until the solid is completely dissolved to obtain a transparent and uniform solution, then carrying out spray drying on the solution to obtain powder, and controlling the water content of the obtained powder to be lower than 5% to obtain the supermolecule salicylic acid-coated oil-controlling antibacterial composition. The pH value of a 10% aqueous solution wrapping the supramolecular salicylic acid oil-control bacteriostatic composition is 4.7.
Comparative example 1
The supramolecular salicylic acid composition comprises the following components in parts by weight: 40 parts of salicylic acid, 45 parts of histidine and 15 parts of glucan.
The preparation method comprises the following steps: stirring a mixture of 45 parts of histidine, 40 parts of salicylic acid and 15 parts of glucan in water, keeping the temperature at 85 ℃, stirring until the solid is completely dissolved to obtain a transparent solution, then carrying out spray drying on the aqueous solution to remove water to obtain powder, and controlling the water content of the obtained powder to be lower than 5% to obtain the non-coated supramolecular salicylic acid composition. The pH of a 10% aqueous solution of the unencapsulated supramolecular salicylic acid was 4.75.
Example 7
The supramolecular-wrapped oil-controlling and bacteriostatic composition obtained in example 1 and supramolecular salicylic acid and salicylic acid monomers obtained in comparative example 1 were applied to a transparent amino acid surfactant shampoo, wherein the shampoo has the following formula 1:
TABLE 1
And (3) carrying out bacteriostasis test on the shampoo samples, wherein the test strain is malassezia furfur.
The test method is according to the evaluation method of the antibacterial and bacteriostatic effects of QB/T2738-2012 daily chemical products. The test strain sample was 1:10 dilution with water. The test results are shown in FIG. 2. The results show that the shampoo added with the wrapped supermolecule oil-control bacteriostatic composition has the bacteriostatic rate of 96.86 percent, the shampoo added with the unwrapped supermolecule salicylic acid has the bacteriostatic rate of 15.2 percent, the shampoo added with the salicylic acid monomer has the bacteriostatic rate of only 7 percent, and the bacteriostatic rate of the unwrapped supermolecule salicylic acid is higher than that of the salicylic acid monomer, but the bacteriostatic rates of the unwrapped supermolecule salicylic acid and the shampoo to malassezia furfur are both lower than 20 percent.
Example 8
Shampoo test of formulation 1 in example 7 was analyzed for relative expression levels of the oil secretion gene.
The testing principle is as follows: sebaceous glands secrete a mixture of lipids including squalene, monoester waxes, free fatty acids, triglycerides, glycerol ether diesters, cholesterol and cholesterol esters, etc., which pass through the hair follicles to the skin surface, forming what is commonly referred to as "oil", also known as free sebum. In a laboratory, the effectiveness of the oil control shampoo on scalp oil secretion control is indirectly determined by testing the influence of the oil control shampoo on the activity of human sebaceous gland cells. The addition of the oil inducer (DHT) can induce the enhancement of the activity of the sebaceous gland cells, and on the contrary, the addition of the oil inducer can induce the enhancement of the sebaceous gland cells and then the addition of the oil-controlling shampoo can indicate that the oil-controlling shampoo can effectively inhibit the secretion of oil if the activity of the sebaceous acyl cells can be re-inhibited.
Comparing the blank group, adding a grease inducer (DHT) into the model group, and indicating that the average expression quantity of the model group exceeds that of the blank control group, so that the model group data has reference value; the test group added 0.016% of the oil-controlling and anti-dandruff shampoo of example 7 on the basis of the same amount of the oil-fat inducer (DHT), and the results are shown in Table 2, wherein the average expression level of the oil-controlling and anti-dandruff shampoo is obviously lower than that of the model group, which indicates that the oil-controlling shampoo has the oil-controlling effect.
TABLE 2 statistical results of the sample experiment group and blank control group
According to the data analysis result, compared with the experimental group using the test product in example 7 and the model group not using the test product, the oil secretion gene is obviously reduced (P < 0.05), and the shampoo in example 7 has obvious oil control effect.
After the shampoo product added with the oil-controlling and anti-dandruff composition is used in an experimental group, the oil secretion genes are obviously lower than those of a model control group, the statistical difference P is less than 0.05, and the difference is obvious.
Example 9
A cosmetic intermediate with oil control and bacteriostasis functions comprises the following components:
100 parts of wrapped supermolecule oil-control bacteriostatic composition in example 1
Glutamic acid diacetic acid tetrasodium 0.1 part
0.1 part of sodium bisulfite.
The above description is only for the purpose of illustrating the technical solutions of the present invention and not for the purpose of limiting the same, and other modifications or equivalent substitutions made by those skilled in the art to the technical solutions of the present invention should be covered within the scope of the claims of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A supermolecule-wrapped oil-control bacteriostatic composition is characterized by comprising organic acid, basic amino acid and cyclodextrin, wherein the organic acid is selected from one or more of salicylic acid, caprylyl glycine, azelaic acid and succinic acid, the organic acid and the basic amino acid are connected and combined into supermolecule organic acid through hydrogen bonds, and the composition contains a cyclodextrin inclusion compound formed by wrapping supermolecule of the organic acid with the cyclodextrin.
2. The wrapped supramolecular oil-controlling and bacteriostatic composition as claimed in claim 1, wherein the mass ratio of the organic acid to the basic amino acid is 1.
3. The wrapped supramolecular oil-controlling and bacteriostatic composition as claimed in claim 1, wherein the mass ratio of the supramolecular organic acid to the cyclodextrin is 1.
4. The wrapped supramolecular oil-controlling and bacteriostatic composition as claimed in claim 1, wherein said organic acid is selected from salicylic acid and caprylyl glycine, the mass ratio of salicylic acid to caprylyl glycine is 1:10-10:1.
5. the wrapped supramolecular oil-controlling and bacteriostatic composition as claimed in claim 1, wherein the cyclodextrin is α -cyclodextrin, β -cyclodextrin, γ -cyclodextrin or derivatives thereof.
6. The coated supramolecular oil-controlling and bacteriostatic composition as claimed in claim 1, wherein said basic amino acid is selected from arginine, histidine or lysine, or one or more of their derivatives, or plant-extracted amino acids containing the above basic amino acids.
7. A method for preparing the coated supermolecule oil-controlling antibacterial composition according to claim 1, wherein the coated supermolecule oil-controlling antibacterial composition is prepared by adding basic amino acid, organic acid and cyclodextrin into water to form a mixed solution, stirring until the mixed solution is transparent and uniform to obtain an aqueous solution of the coated supermolecule organic acid, and drying and dehydrating the aqueous solution.
8. A cosmetic intermediate comprising the coated supramolecular oil-controlling bacteriostatic composition of claim 1.
9. The cosmetic intermediate of claim 8, comprising a chelating agent and/or an antioxidant.
10. Use of the coated supramolecular oil-controlling and bacteriostatic composition disclosed in claim 1 in cosmetics.
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| CN202211457975.8A CN115919682A (en) | 2022-11-16 | 2022-11-16 | Coated supermolecule oil-control antibacterial composition, preparation method and application thereof |
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| CN107970165A (en) * | 2017-12-26 | 2018-05-01 | 广州在路上信息科技有限公司 | A kind of oil-control dandruff control shampoo containing and preparation method thereof |
| CN114028265A (en) * | 2021-12-16 | 2022-02-11 | 爱西美(珠海)生物技术有限公司 | Supermolecule embedded salicylic acid and preparation method thereof |
| CN114306123A (en) * | 2021-11-19 | 2022-04-12 | 深圳市萱嘉生物科技有限公司 | Preparation method and application of salicylic acid ionic salt/eutectic cyclodextrin inclusion liposome |
| CN114366692A (en) * | 2022-01-26 | 2022-04-19 | 山东福瑞达生物股份有限公司 | Oil-control acne-removing composition and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107970165A (en) * | 2017-12-26 | 2018-05-01 | 广州在路上信息科技有限公司 | A kind of oil-control dandruff control shampoo containing and preparation method thereof |
| CN114306123A (en) * | 2021-11-19 | 2022-04-12 | 深圳市萱嘉生物科技有限公司 | Preparation method and application of salicylic acid ionic salt/eutectic cyclodextrin inclusion liposome |
| CN114028265A (en) * | 2021-12-16 | 2022-02-11 | 爱西美(珠海)生物技术有限公司 | Supermolecule embedded salicylic acid and preparation method thereof |
| CN114366692A (en) * | 2022-01-26 | 2022-04-19 | 山东福瑞达生物股份有限公司 | Oil-control acne-removing composition and application thereof |
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