CN115916256A - 抗sars冠状病毒2型刺突蛋白抗体 - Google Patents
抗sars冠状病毒2型刺突蛋白抗体 Download PDFInfo
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- CN115916256A CN115916256A CN202180029893.0A CN202180029893A CN115916256A CN 115916256 A CN115916256 A CN 115916256A CN 202180029893 A CN202180029893 A CN 202180029893A CN 115916256 A CN115916256 A CN 115916256A
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1002—Coronaviridae
- C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
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- G—PHYSICS
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- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/10—Detection of antigens from microorganism in sample from host
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
Abstract
本公开提供了特异性识别SARS‑CoV‑2S蛋白的抗体或其抗原结合片段。本公开所述的抗体或其抗原结合片段可配制成药物组合物和/或用于各种诊断、治疗或分子生物学应用。
Description
相关申请的交叉引用
本申请要求2020年4月24日提交的第63/015,037号美国临时专利申请的优先权,该专利申请的全部内容通过引用并入本文。
并入序列表
本专利申请包含一个序列表,该序列表通过电子方式随同本申请提交,其全部内容通过引用并入本文。ASCII副本创建于2021年4月23日,命名为SCT0013-401-PC_序列_列表_ST25.txt,大小为485,209字节。
背景技术
冠状病毒(CoV)是普通感冒的常见病因,可在全世界所有年龄段人群中引起上呼吸道感染(Greenberg,2011)。对比严重急性呼吸综合征冠状病毒(SARS-CoV)和中东呼吸综合征冠状病毒(MERS-CoV),这两者均为人畜共患病毒,会分别在受影响个体中引起严重的呼吸系统疾病,即SARS和MERS(Fehr等人,2017)。SARS于2002年在全球传播,共确诊8,096例,死亡774例(de Wit等人,2016)。MERS于2012年在沙特阿拉伯吉达出现。截至2016年8月11日,已确诊感染MERS-CoV患者1,791例,死亡640例(http://www.who.int/emergencies/mers-cov/en/)。目前,尚无对抗SARS或MERS的特效抗病毒药物或获批疫苗,2002年和2003年的SARS大流行最终是通过常规控制措施而得以阻止,MERS疫情爆发也是如此。
一种被称为新型冠状病毒肺炎(COVID-19)的疾病在患者体内检出,与SARS-CoV(SARS病毒)密切相关,即SARS冠状病毒2型(SARS-CoV-2),被认为是COVID-19的病原体(Zhu等人,2020)。
其症状类似普通感冒。截至2020年4月15日,全球确诊病例1,918,138例,相关死亡病例123,126例(https://covid19.who.int/)。
事实证明,在2002-2003年SARS疫情爆发期间,隔离措施能有效控制住疫情,同样的策略似乎也适用于COVID-19大流行,但截至2020年4月,还尚无成熟的治疗方法。因此,仍亟需针对COVID-19的靶向有效治疗。
该病毒在感染后约5~6天达到SARS-CoV-2病毒载量峰值,从而能够开展有效的暴露后治疗(Pan等人,2020)。一种可能限制病毒复制并因此限制其传播的治疗方式是采用中和重组人单克隆抗体(mAb)进行被动免疫。在疾病前驱期进行这种治疗有助于快速清除该病毒,并限制不良临床结局和“人传人”现象,而不会出现与使用皮质类固醇、动物血清或人血清相关的副作用。
SARS-CoV-2会借助密集的糖基化刺突(S)蛋白进入宿主细胞。以下是关于SARS-CoV的发现,但由于SARS-CoV-2与其在DNA序列水平上密切相关,因此其中许多发现也与SARS-CoV-2相关。S蛋白是一种三聚体I类融合蛋白,以亚稳态融合前构象存在,经过显著的结构重排,使病毒膜与宿主细胞膜融合(Li,2016;Bosch等人,2003)。当S1亚基与宿主细胞受体结合时,会触发这一过程。受体结合会使融合前三聚体结构变得不稳定,导致S1亚基脱落和S2亚基转变为稳定的融合后构象(Walls等人,2017)。为与宿主细胞受体结合,S1的受体结合结构域(RBD)会进行铰链样构象运动,从而暂时隐藏或暴露受体结合的决定簇。S蛋白的S2结构域会通过构象变化介导病毒和宿主膜的融合,使S蛋白的两个保守螺旋区(HR1和HR2)结合在一起形成一个六螺旋束融合核心,从而导致靶细胞受到感染(He等人,2005a)。
S蛋白是引起保护性免疫反应的主要抗原,包括受感染人类和动物中产生的中和抗体(Bisht等人,2004;Buchholz等人,2004;Cheng等人,2005;Greenough等人,2005;He等人,2005b;Hofmann等人,2004)。采用对S序列进行编码的DNA疫苗免疫小鼠(不含细胞质结构域和/或跨膜结构域),会产生中和抗体以及CD4+和CD8+T细胞应答(Yang等人,2004)。然而,抑制病毒复制的并非是细胞免疫,而是体液(IgG)成分免疫(Yang等人,2004)。事实上,中国的恢复期血浆疗法已取得相当成效(Duan等人,2020)。总之,这些研究表明,SARS-CoV复制主要是依靠抗体进行抑制,且被动转移抗SARS-CoV的中和抗体具有潜在治疗价值。S蛋白的免疫原性包括其诱导产生中和抗体的能力及其在病毒附着和融合中发挥的重要作用,使其成为开发预防SARS-CoV-2感染的有效免疫疗法的理想靶标。
在疫情爆发期间,冠状病毒可能会产生突变并表现出抗原变异。事实上,序列分析表明,临床分离株可分为早期、中期和晚期分离株(Sui等人,2005)。这有助于后续分离株依靠能有效中和早期分离株的单克隆抗体来逃逸中和作用(Yang等人,2005)。因此,生产对具有抗原多样性的广泛临床分离株有效的中和性单克隆抗体(mAb)非常重要。由于抗原变体会发生潜在进化,因此针对SARS-CoV-2的有效被动疗法将可能包含以不同表位和/或入侵过程(如阻断受体结合和融合或Fc信号转导)中的步骤为靶标的中和抗体混合物。
用合适的抗病毒免疫球蛋白(如本发明中公开的免疫球蛋白)经过适当的人源化后进行被动治疗,可提供即时保护。因此,仍然迫切需要用于治疗SARS-CoV-2感染的有效广谱抗体疗法。
发明内容
本公开提供的抗体可识别SARS-CoV-2S蛋白并与之进行特异性结合。在一个实施例中,本公开提供了与SEQ ID NO:1结合的一种抗体。
序列说明
表1
附图说明
图1.所示为所选抗SARS-CoV-2抗体亚组的表位区段(bin)图。而圆圈内的抗体要么具有相同表位,要么具有在很大程度上重叠的表位。重叠圆圈表示BLI测定在描绘区段的确切边界方面的局限性。
重叠区段可能意味着表位重叠程度较低。例如,SCT-La190和SCT-La115不在单独的区段中,而SCT-La102肯定在单独的区段中。
图2.所示为所选抗体亚组的滴定图,该图显示了其抑制报告病毒颗粒(rvp)感染适当宿主细胞的能力。数据点显示,在较低浓度下具有显著抑制水平的抗体效力更高。每种抗体的IC50值可根据所示数据点合理计算得出。
具体实施方式
本公开提供了与SARS-CoV-2S蛋白进行结合的抗体。在一个实施例中,本公开提供了与SEQ ID NO:1结合的一种分离的抗体。
抗体
本公开提供了与SEQ ID NO:1进行特异性结合的抗体。本文所用“抗体”一词包括全长免疫球蛋白以及与BCMA进行结合的抗体片段。该等抗体可以是单克隆抗体、多克隆抗体、嵌合抗体、人源化抗体或单链抗体等。如本文所用,“抗原结合片段”、“片段”和“抗体片段”等词可互换使用,是指包含全长抗体一部分的任何片段,通常至少是抗原结合部分或其可变区。抗体片段示例包括但不限于纳米抗体、双抗体、双特异性T细胞接合物、单链抗体分子、多特异性抗体(例如,双特异性)、Fab、Fab’、F(ab')2、Fv或scFv。
考虑了包含本文所述所有抗体抗原结合片段的组合物。
如本文所用,“赋形剂”一词是指与药物活性成分一同进行配制的天然或合成物质,包括用于长期稳定、填充固体制剂的目的,或为了赋予最终剂型中活性成分治疗增强作用,如促进药物吸收、降低粘度或增强溶解性。
短语“治疗上有效”旨在限定治疗疾病或病症或影响临床终点用活性成分的量。
“治疗上可接受”一词是指那些适于与患者组织接触,而无过度毒性、刺激和过敏反应,效益/风险比合理,并对其预期用途有效的化合物(或盐、前药、互变异构体、两性离子形式等)。
本文所用“治疗”等词是指改善疾病,从而减少、改善或消除其病因、进展、严重程度或一种或多种症状,或者以有益的方式改变受试者的疾病。提及的患者“治疗”旨在包括预防。治疗本质上也可以是先驱性治疗,即可以包括帮助暴露于疾病或有患病风险的受试者预防疾病。预防疾病可能涉及完全防止疾病,例如在预防病原体感染的情况下,或者可能涉及预防疾病进展。例如,预防疾病可能并不意味着在任何水平上完全排除与疾病相关的任何影响,而可能意味着将疾病症状防治到临床上显著或可检测的水平。预防疾病也可以指预防疾病发展到疾病的晚期。
“受试者”和“患者”等词在本文中可互换使用,是指包括人在内的所有哺乳动物。受试者的示例包括但不限于人、猴子、狗、猫、马、牛、山羊、绵羊、猪和兔子。在一个实施例中,受试者或患者是人。
如本文所用,“中症COVID-19”是指通过临床评估或成像具有下呼吸道疾病迹象,并且海平面室内空气中氧饱和度(SpO2)≥94%的个体。虽然可以基于临床依据来作出诊断;但胸部成像(X光片、CT扫描、超声波)可能有助于诊断和确定或排除肺部并发症。
如本文所用,“护理标准”或“SOC”是指临床医生对于特定类型的患者、疾病或临床情况应遵循的诊断和治疗过程。SOC可包括给予临床实践中用于治疗COVID-19的药物(例如,洛匹那韦/利托那韦;达芦那韦/科比司他;羟基氯喹、妥昔单抗等),但用于另一项临床试验的药物除外。
如本文所用,“急性呼吸窘迫综合征”或“ARDS”是一种呼吸衰竭,其特征是肺部广泛炎症快速发作。症状包括气短、呼吸急促和皮肤发绀。
在某些实施例中,本公开所提供的抗体可用于识别感染SARS-CoV-2的患者,方法是通过其S蛋白来特异性地检测病毒。
这种检测很有必要,有助于保护一线医护人员,使之与感染病毒的人员隔离,并在他们病情恶化之前对其进行治疗。流行病学家可以可靠地确定高发地区的已感染受试者,以便更好地衡量疫情的程度,政府官员也可利用这些结果来帮助决定何时以及如何恢复居民的日常生活。最重要的是,这是经济复苏的关键,因为可以识别和隔离受感染人群,使社会其余部分能够正常运作。
在一方面,本公开提供了一种组合物或试剂盒,包含如上文或本文所述并与另一种治疗剂结合使用的抗体或抗原结合片段。
在一方面,本发明提供了一种药物组合物,包含如上文或本文所述的抗原结合蛋白、抗体或抗原结合片段和药学上可接受的载体,以及可选的另一种治疗剂。在一些实施例中,该另一种治疗剂是抗病毒药物或疫苗。在一些实施例中,该另一种治疗剂选自以下药物的组合:抗炎剂和抗疟疾剂。在某些情况下,该抗疟疾剂为氯喹或羟基氯喹。在某些情况下,该抗炎剂为抗体,如沙立芦人单抗、托珠单抗或瑾司鲁单抗。在一些实施例中,该另一种治疗剂是包含表3的HCDR1、HCDR2、HCDR3、LCDR1、LCDR2和LCDR3序列的第二抗体或抗原结合片段。
在一方面,本公开提供了一种药物组合物,包含如上文或本文所述的分离抗体或其抗原结合片段,以及药学上可接受的载体或稀释剂。在一些实施例中,该药物组合物包含一种或多种赋形剂。
在一些实施例中,该药物组合物还包含第二种治疗剂。在一些情况下,第二种治疗剂选自以下药物的组合:第二种抗体或其抗原结合片段(与包含SEQ ID NO:1中所述氨基酸序列的SARS-CoV-2刺突蛋白结合)、抗炎剂和抗疟疾剂。
本公开提供了与SEQ ID NO:1进行特异性结合的抗体。本文所用“抗体”一词包括全长免疫球蛋白和与相同抗原结合的抗体片段。该等抗体可以是单克隆抗体、多克隆抗体、嵌合抗体、人源化抗体或单链抗体等。
所提供的抗体可用于诊断、治疗或监测SARS-CoV-2病毒感染。
在一些实施例中,本文所述抗体或其片段可用于各种体外分子生物学应用,如酶联免疫吸附测定(ELISA)、免疫印迹试验、免疫组织化学、免疫细胞化学、流式细胞术和荧光激活细胞分选(FACS)、免疫沉淀和/或酶联免疫斑点检测。在一些实施例中,抗体或其片段可被包装在试剂盒中,其中有或没有本领域技术人员已知的用于实施上述任何分子生物学技术的附加试剂。
在另一方面,本公开提供了一种预防或治疗有需要的受试者的SARS-CoV-2感染的方法,包括向受试者施用治疗上或预防上有效量的药物组合物,其中包含一种或多种本文所述抗体。这种方法可包括按照任何剂量施用有效改善或治疗SARS-CoV-2感染症状的本文所述抗体。
在一些实施例中,可对暴露于SARS-CoV-2的受试者施用包含一种或多种本文所述抗体的药物组合物。在一些实施例中,本文所述药物组合物可单独施用或与临床医师或从业者认为合适的其他疗法组合施用。在一些实施例中,本文所述药物组合物可将COVID-19症状的天数减少一天或多天,例如将症状减少1、2、3、4、5、6、7、8、9、10、11、12、13、14天。
在另一方面,本公开提供了减少、延缓或以其他方式抑制已确诊COVID-19个体中SARS-CoV-2生长和/或复制的方法,包括施用包含一种或多种本文所述抗体的药物组合物。
在一些实施例中,COVID-19的严重程度为中症。在一些实施例中,本文所述一种或多种抗体的预防或治疗剂量的用药在疾病发作的24至72小时内或个体确诊患有COVID-19开始,以较早者为准。在一些实施例中,在疾病发作24小时内或个体确认患有COVID-19时开始用药,以较早者为准。
在一些实施例中,个体暴露于SARS-CoV-2的风险较高。在一些实施例中,个体是卫生保健工作者。在一些实施例中,个体位于已报告SARS-CoV-2正在社区传播的区域。在一些实施例中,个体与一名或多名COVID-19患者有过密切接触。
在一些实施例中,个体患严重疾病的风险较高。在一些实施例中,个体为60岁或以上。在一些实施例中,个体患有严重的慢性疾病。在一些实施例中,慢性疾病选自肺病、糖尿病(2型)、需要口服药物或胰岛素治疗、高血压、心血管疾病。
在一些实施例中,个体在静息时的基线血压收缩压低于110mmHg。在一些实施例中,个体的体重指数≥30。
在一些实施例中,方法进一步包括检测个体的SARS-CoV-2感染。在一些实施例中,测试包括通过实时逆转录-聚合酶链式反应(rRT-PCR)测定来检测鼻咽和口咽拭子。此测定方法的描述以及rRT-PCR组引物和探针的序列信息可在2019-nCoV的CDC实验室信息网站(https://www.cdc.gov/coronavirus/2019-nCoV/lab/index.html)上获得,其全部内容通过引用并入本文。
本公开提供了抗体SCT-La001、SCT-La002、SCT-La003、SCT-La004,SCT-La005,SCT-La006,SCT-La007,SCT-La008,SCT-La009,SCT-La010,SCT-La011,SCT-La012,SCT-La013,SCT-La014,SCT-La015,SCT-La016,SCT-La017,SCT-La018,SCT-La019,SCT-La020,SCT-La021,SCT-La022,SCT-La023,SCT-La024,SCT-La025,SCT-La026,SCT-La027,SCT-La028,SCT-La029,SCT-La030,SCT-La031,SCT-La032,SCT-La033,SCT-La034,SCT-La035,SCT-La036,SCT-La037,SCT-La038,SCT-La039,SCT-La040,SCT-La041,SCT-La042,SCT-La043,SCT-La044,SCT-La045,SCT-La046,SCT-La047,SCT-La048,SCT-La049,SCT-La050,SCT-La051,SCT-La052,SCT-La053,SCT-La054,SCT-La055,SCT-La056,SCT-La057,SCT-La058,SCT-La059,SCT-La060,SCT-La061,SCT-La062,SCT-La063,SCT-La064,SCT-La065,SCT-La066,SCT-La067,SCT-La068,SCT-La069,SCT-La070,SCT-La071,SCT-La072,SCT-La073,SCT-La074,SCT-La075,SCT-La076,SCT-La077,SCT-La078,SCT-La079,SCT-La080,SCT-La081,SCT-La082,SCT-La083,SCT-La084,SCT-La085,SCT-La086,SCT-La087,SCT-La088,SCT-La089,SCT-La090,SCT-La091,SCT-La092,SCT-La093,SCT-La094,SCT-La095,SCT-La096,SCT-La097,SCT-La098,SCT-La099,SCT-La100,SCT-La101,SCT-La102,SCT-La103,SCT-La104,SCT-La105,SCT-La106,SCT-La107,SCT-La108,SCT-La109,SCT-La110,SCT-La111,SCT-La112,SCT-La113,SCT-La114,SCT-La115,SCT-La116,SCT-La117,SCT-La118,SCT-La119,SCT-La120,SCT-La121,SCT-La122,SCT-La123,SCT-La124,SCT-La125,SCT-La126,SCT-La127,SCT-La128,SCT-La129,SCT-La130,SCT-La131,SCT-La132,SCT-La133,SCT-La134,SCT-La135,SCT-La136,SCT-La137,SCT-La138,SCT-La139,SCT-La140,SCT-La141,SCT-La142,SCT-La143,SCT-La144,SCT-La145,SCT-La146,SCT-La147,SCT-La148,SCT-La149,SCT-La150,SCT-La151,SCT-La152,SCT-La153,SCT-La154,SCT-La155,SCT-La156,SCT-La157,SCT-La158,SCT-La159,SCT-La160,SCT-La161,SCT-La162,SCT-La163,SCT-La164,SCT-La165,SCT-La166,SCT-La167,SCT-La168,SCT-La169,SCT-La170,SCT-La171,SCT-La172,SCT-La173,SCT-La174,SCT-La175,SCT-La176,SCT-La177,SCT-La178,SCT-La179,SCT-La180,SCT-La181,SCT-La182,SCT-La183,SCT-La184,SCT-La185,SCT-La186,SCT-La187,SCT-La188,SCT-La189,SCT-La190,SCT-La191,SCT-La192,SCT-La193,SCT-La194,SCT-La195,SCT-La196,SCT-La197,SCT-La198,SCT-La199,SCT-La200,SCT-La201,SCT-La202,SCT-La203,SCT-La204,SCT-La205,SCT-La206,SCT-La207,SCT-La208,SCT-La209,SCT-La210,SCT-La211,SCT-La212,SCT-La213,SCT-La214,SCT-La215,SCT-La216,SCT-La217,SCT-La218,SCT-La219,SCT-La220,SCT-La221,SCT-La222,SCT-La223,SCT-La224,and SCT-La225。其中每一种都是鼠单克隆抗体。
此外,重组抗SARS-CoV-2S蛋白抗体,例如嵌合和人源化单克隆抗体,包含人和非人部分,其可使用标准重组DNA技术制备,也包含在本公开的范围内。此类嵌合和人源化单克隆抗体可通过重组DNA技术来生产,例如第7,112,421号美国专利;Better等人(1988)《科学》240:1041-1043;或Liu等人(1987)《美国国家科学院院刊》84,3439-3443中描述的方法。
抗体可变结构域序列
本公开的抗体可包含以下重链可变结构域序列:SEQ ID NO:5、SEQ ID NO:6、SEQID NO:7、SEQ ID NO:8、SEQ ID NO:9,SEQ ID NO:10,SEQ ID NO:11,SEQ ID NO:12,SEQ IDNO:13,SEQ ID NO:14,SEQ ID NO:15,SEQ ID NO:16,SEQ ID NO:17,SEQ ID NO:18,SEQ IDNO:19,SEQ ID NO:20,SEQ ID NO:21,SEQ ID NO:22,SEQ ID NO:23,SEQ ID NO:24,SEQ IDNO:25,SEQ ID NO:26,SEQ ID NO:27,SEQ ID NO:28,SEQ ID NO:29,SEQ ID NO:30,SEQ IDNO:31,SEQ ID NO:32,SEQ ID NO:33,SEQ ID NO:34,SEQ ID NO:35,SEQ ID NO:36,SEQ IDNO:37,SEQ ID NO:38,SEQ ID NO:39,SEQ ID NO:40,SEQ ID NO:41,SEQ ID NO:42,SEQ IDNO:43,SEQ ID NO:44,SEQ ID NO:45,SEQ ID NO:46,SEQ ID NO:47,SEQ ID NO:48,SEQ IDNO:49,SEQ ID NO:50,SEQ ID NO:51,SEQ ID NO:52,SEQ ID NO:53,SEQ ID NO:54,SEQ IDNO:55,SEQ ID NO:56,SEQ ID NO:57,SEQ ID NO:58,SEQ ID NO:59,SEQ ID NO:60,SEQ IDNO:61,SEQ ID NO:62,SEQ ID NO:63,SEQ ID NO:64,SEQ ID NO:65,SEQ ID NO:66,SEQ IDNO:67,SEQ ID NO:68,SEQ ID NO:69,SEQ ID NO:70,SEQ ID NO:71,SEQ ID NO:72,SEQ IDNO:73,SEQ ID NO:74,SEQ ID NO:75,SEQ ID NO:76,SEQ ID NO:77,SEQ ID NO:78,SEQ IDNO:79,SEQ ID NO:80,SEQ ID NO:81,SEQ ID NO:82,SEQ ID NO:83,SEQ ID NO:84,SEQ IDNO:85,SEQ ID NO:86,SEQ ID NO:87,SEQ ID NO:88,SEQ ID NO:89,SEQ ID NO:90,SEQ IDNO:91,SEQ ID NO:92,SEQ ID NO:93,SEQ ID NO:94,SEQ ID NO:95,SEQ ID NO:96,SEQ IDNO:97,SEQ ID NO:98,SEQ ID NO:99,SEQ ID NO:100,SEQ ID NO:101,SEQ ID NO:102,SEQID NO:103,SEQ ID NO:104,SEQ ID NO:105,SEQ ID NO:106,SEQ ID NO:107,SEQ ID NO:108,SEQ ID NO:109,SEQ ID NO:110,SEQ ID NO:111,SEQ ID NO:112,SEQ ID NO:113,SEQID NO:114,SEQ ID NO:115,SEQ ID NO:116,SEQ ID NO:117,SEQ ID NO:118,SEQ ID NO:119,SEQ ID NO:120,SEQ ID NO:121,SEQ ID NO:122,SEQ ID NO:123,SEQ ID NO:124,SEQID NO:125,SEQ ID NO:126,SEQ ID NO:127,SEQ ID NO:128,SEQ ID NO:129,SEQ ID NO:130,SEQ ID NO:131,SEQ ID NO:132,SEQ ID NO:133,SEQ ID NO:134,SEQ ID NO:135,SEQID NO:136,SEQ ID NO:137,SEQ ID NO:138,SEQ ID NO:139,SEQ ID NO:140,SEQ ID NO:141,SEQ ID NO:142,SEQ ID NO:143,SEQ ID NO:144,SEQ ID NO:145,SEQ ID NO:146,SEQID NO:147,SEQ ID NO:148,SEQ ID NO:149,SEQ ID NO:150,SEQ ID NO:151,SEQ ID NO:152,SEQ ID NO:153,SEQ ID NO:154,SEQ ID NO:155,SEQ ID NO:156,SEQ ID NO:157,SEQID NO:158,SEQ ID NO:159,SEQ ID NO:160,SEQ ID NO:161,SEQ ID NO:162,SEQ ID NO:163,SEQ ID NO:164,SEQ ID NO:165,SEQ ID NO:166,SEQ ID NO:167,SEQ ID NO:168,SEQID NO:169,SEQ ID NO:170,SEQ ID NO:171,SEQ ID NO:172,SEQ ID NO:173,SEQ ID NO:174,SEQ ID NO:175,SEQ ID NO:176,SEQ ID NO:177,SEQ ID NO:178,SEQ ID NO:179,SEQID NO:180,SEQ ID NO:181,SEQ ID NO:182,SEQ ID NO:183,SEQ ID NO:184,SEQ ID NO:185,SEQ ID NO:186,SEQ ID NO:187,SEQ ID NO:188,SEQ ID NO:189,SEQ ID NO:190,orSEQ ID NO:191.重链可变结构域序列基本上可包含SEQ ID NO:5、SEQ ID NO:6,SEQ IDNO:7,SEQ ID NO:8,SEQ ID NO:9,SEQ ID NO:10,SEQ ID NO:11,SEQ ID NO:12,SEQ IDNO:13,SEQ ID NO:14,SEQ ID NO:15,SEQ ID NO:16,SEQ ID NO:17,SEQ ID NO:18,SEQ IDNO:19,SEQ ID NO:20,SEQ ID NO:21,SEQ ID NO:22,SEQ ID NO:23,SEQ ID NO:24,SEQ IDNO:25,SEQ ID NO:26,SEQ ID NO:27,SEQ ID NO:28,SEQ ID NO:29,SEQ ID NO:30,SEQ IDNO:31,SEQ ID NO:32,SEQ ID NO:33,SEQ ID NO:34,SEQ ID NO:35,SEQ ID NO:36,SEQ IDNO:37,SEQ ID NO:38,SEQ ID NO:39,SEQ ID NO:40,SEQ ID NO:41,SEQ ID NO:42,SEQ IDNO:43,SEQ ID NO:44,SEQ ID NO:45,SEQ ID NO:46,SEQ ID NO:47,SEQ ID NO:48,SEQ IDNO:49,SEQ ID NO:50,SEQ ID NO:51,SEQ ID NO:52,SEQ ID NO:53,SEQ ID NO:54,SEQ IDNO:55,SEQ ID NO:56,SEQ ID NO:57,SEQ ID NO:58,SEQ ID NO:59,SEQ ID NO:60,SEQ IDNO:61,SEQ ID NO:62,SEQ ID NO:63,SEQ ID NO:64,SEQ ID NO:65,SEQ ID NO:66,SEQ IDNO:67,SEQ ID NO:68,SEQ ID NO:69,SEQ ID NO:70,SEQ ID NO:71,SEQ ID NO:72,SEQ IDNO:73,SEQ ID NO:74,SEQ ID NO:75,SEQ ID NO:76,SEQ ID NO:77,SEQ ID NO:78,SEQ IDNO:79,SEQ ID NO:80,SEQ ID NO:81,SEQ ID NO:82,SEQ ID NO:83,SEQ ID NO:84,SEQ IDNO:85,SEQ ID NO:86,SEQ ID NO:87,SEQ ID NO:88,SEQ ID NO:89,SEQ ID NO:90,SEQ IDNO:91,SEQ ID NO:92,SEQ ID NO:93,SEQ ID NO:94,SEQ ID NO:95,SEQ ID NO:96,SEQ IDNO:97,SEQ ID NO:98,SEQ ID NO:99,SEQ ID NO:100,SEQ ID NO:101,SEQ ID NO:102,SEQID NO:103,SEQ ID NO:104,SEQ ID NO:105,SEQ ID NO:106,SEQ ID NO:107,SEQ ID NO:108,SEQ ID NO:109,SEQ ID NO:110,SEQ ID NO:111,SEQ ID NO:112,SEQ ID NO:113,SEQID NO:114,SEQ ID NO:115,SEQ ID NO:116,SEQ ID NO:117,SEQ ID NO:118,SEQ ID NO:119,SEQ ID NO:120,SEQ ID NO:121,SEQ ID NO:122,SEQ ID NO:123,SEQ ID NO:124,SEQID NO:125,SEQ ID NO:126,SEQ ID NO:127,SEQ ID NO:128,SEQ ID NO:129,SEQ ID NO:130,SEQ ID NO:131,SEQ ID NO:132,SEQ ID NO:133,SEQ ID NO:134,SEQ ID NO:135,SEQID NO:136,SEQ ID NO:137,SEQ ID NO:138,SEQ ID NO:139,SEQ ID NO:140,SEQ ID NO:141,SEQ ID NO:142,SEQ ID NO:143,SEQ ID NO:144,SEQ ID NO:145,SEQ ID NO:146,SEQID NO:147,SEQ ID NO:148,SEQ ID NO:149,SEQ ID NO:150,SEQ ID NO:151,SEQ ID NO:152,SEQ ID NO:153,SEQ ID NO:154,SEQ ID NO:155,SEQ ID NO:156,SEQ ID NO:157,SEQID NO:158,SEQ ID NO:159,SEQ ID NO:160,SEQ ID NO:161,SEQ ID NO:162,SEQ ID NO:163,SEQ ID NO:164,SEQ ID NO:165,SEQ ID NO:166,SEQ ID NO:167,SEQ ID NO:168,SEQID NO:169,SEQ ID NO:170,SEQ ID NO:171,SEQ ID NO:172,SEQ ID NO:173,SEQ ID NO:174,SEQ ID NO:175,SEQ ID NO:176,SEQ ID NO:177,SEQ ID NO:178,SEQ ID NO:179,SEQID NO:180,SEQ ID NO:181,SEQ ID NO:182,SEQ ID NO:183,SEQ ID NO:184,SEQ ID NO:185,SEQ ID NO:186,SEQ ID NO:187,SEQ ID NO:188,SEQ ID NO:189,SEQ ID NO:190、或SEQ ID NO:191。
本公开的抗体可包含以下轻链可变结构域序列:SEQ ID NO:192、SEQ ID NO:193、SEQ ID NO:194、SEQ ID NO:195、SEQ ID NO:196,SEQ ID NO:197,SEQ ID NO:198,SEQ IDNO:199,SEQ ID NO:200,SEQ ID NO:201,SEQ ID NO:202,SEQ ID NO:203,SEQ ID NO:204,SEQ ID NO:205,SEQ ID NO:206,SEQ ID NO:207,SEQ ID NO:208,SEQ ID NO:209,SEQ IDNO:210,SEQ ID NO:211,SEQ ID NO:212,SEQ ID NO:213,SEQ ID NO:214,SEQ ID NO:215,SEQ ID NO:216,SEQ ID NO:217,SEQ ID NO:218,SEQ ID NO:219,SEQ ID NO:220,SEQ IDNO:221,SEQ ID NO:222,SEQ ID NO:223,SEQ ID NO:224,SEQ ID NO:225,SEQ ID NO:226,SEQ ID NO:227,SEQ ID NO:228,SEQ ID NO:229,SEQ ID NO:230,SEQ ID NO:231,SEQ IDNO:232,SEQ ID NO:233,SEQ ID NO:234,SEQ ID NO:235,SEQ ID NO:236,SEQ ID NO:237,SEQ ID NO:238,SEQ ID NO:239,SEQ ID NO:240,SEQ ID NO:241,SEQ ID NO:242,SEQ IDNO:243,SEQ ID NO:244,SEQ ID NO:245,SEQ ID NO:246,SEQ ID NO:247,SEQ ID NO:248,SEQ ID NO:249,SEQ ID NO:250,SEQ ID NO:251,SEQ ID NO:252,SEQ ID NO:253,SEQ IDNO:254,SEQ ID NO:255,SEQ ID NO:256,SEQ ID NO:257,SEQ ID NO:258,SEQ ID NO:259,SEQ ID NO:260,SEQ ID NO:261,SEQ ID NO:262,SEQ ID NO:263,SEQ ID NO:264,SEQ IDNO:265,SEQ ID NO:266,SEQ ID NO:267,SEQ ID NO:268,SEQ ID NO:269,SEQ ID NO:270,SEQ ID NO:271,SEQ ID NO:272,SEQ ID NO:273,SEQ ID NO:274,SEQ ID NO:275,SEQ IDNO:276,SEQ ID NO:277,SEQ ID NO:278,SEQ ID NO:279,SEQ ID NO:280,SEQ ID NO:281,SEQ ID NO:282,SEQ ID NO:283,SEQ ID NO:284,SEQ ID NO:285,SEQ ID NO:286,SEQ IDNO:287,SEQ ID NO:288,SEQ ID NO:289,SEQ ID NO:290,SEQ ID NO:291,SEQ ID NO:292,SEQ ID NO:293,SEQ ID NO:294,SEQ ID NO:295,SEQ ID NO:296,SEQ ID NO:297,SEQ IDNO:298,SEQ ID NO:299,SEQ ID NO:300,SEQ ID NO:301,SEQ ID NO:302,SEQ ID NO:303,SEQ ID NO:304,SEQ ID NO:305,SEQ ID NO:306,SEQ ID NO:307,SEQ ID NO:308,SEQ IDNO:309,SEQ ID NO:310,SEQ ID NO:311,SEQ ID NO:312,SEQ ID NO:313,SEQ ID NO:314,SEQ ID NO:315,SEQ ID NO:316,SEQ ID NO:317,SEQ ID NO:318,SEQ ID NO:319,SEQ IDNO:320,SEQ ID NO:321,SEQ ID NO:322,SEQ ID NO:323,SEQ ID NO:324,SEQ ID NO:325,SEQ ID NO:326,SEQ ID NO:327,SEQ ID NO:328,SEQ ID NO:329,SEQ ID NO:330,SEQ IDNO:331,SEQ ID NO:332,SEQ ID NO:333,SEQ ID NO:334,SEQ ID NO:335,SEQ ID NO:336,SEQ ID NO:337,SEQ ID NO:338,SEQ ID NO:339,SEQ ID NO:340,SEQ ID NO:341,SEQ IDNO:342,SEQ ID NO:343,SEQ ID NO:344,SEQ ID NO:345,SEQ ID NO:346,SEQ ID NO:347,SEQ ID NO:348,SEQ ID NO:349,SEQ ID NO:350,SEQ ID NO:351,SEQ ID NO:352,SEQ IDNO:353,SEQ ID NO:354,SEQ ID NO:355,SEQ ID NO:356,SEQ ID NO:357,SEQ ID NO:358,SEQ ID NO:359,SEQ ID NO:360,SEQ ID NO:361,SEQ ID NO:362,SEQ ID NO:363,SEQ IDNO:364,SEQ ID NO:365,SEQ ID NO:366,SEQ ID NO:367,SEQ ID NO:368,SEQ ID NO:369,SEQ ID NO:370,SEQ ID NO:371,SEQ ID NO:372,SEQ ID NO:373,SEQ ID NO:374,SEQ IDNO:375,SEQ ID NO:376、SEQ ID NO:377、SEQ ID NO:378、SEQ ID NO:379、SEQ ID NO:380、或SEQ ID NO:381。轻链可变结构域序列基本上可包含SEQ ID NO:192,SEQ ID NO:193,SEQID NO:194,SEQ ID NO:195,SEQ ID NO:196,SEQ ID NO:197,SEQ ID NO:198,SEQ ID NO:199,SEQ ID NO:200,SEQ ID NO:201,SEQ ID NO:202,SEQ ID NO:203,SEQ ID NO:204,SEQID NO:205,SEQ ID NO:206,SEQ ID NO:207,SEQ ID NO:208,SEQ ID NO:209,SEQ ID NO:210,SEQ ID NO:211,SEQ ID NO:212,SEQ ID NO:213,SEQ ID NO:214,SEQ ID NO:215,SEQID NO:216,SEQ ID NO:217,SEQ ID NO:218,SEQ ID NO:219,SEQ ID NO:220,SEQ ID NO:221,SEQ ID NO:222,SEQ ID NO:223,SEQ ID NO:224,SEQ ID NO:225,SEQ ID NO:226,SEQID NO:227,SEQ ID NO:228,SEQ ID NO:229,SEQ ID NO:230,SEQ ID NO:231,SEQ ID NO:232,SEQ ID NO:233,SEQ ID NO:234,SEQ ID NO:235,SEQ ID NO:236,SEQ ID NO:237,SEQID NO:238,SEQ ID NO:239,SEQ ID NO:240,SEQ ID NO:241,SEQ ID NO:242,SEQ ID NO:243,SEQ ID NO:244,SEQ ID NO:245,SEQ ID NO:246,SEQ ID NO:247,SEQ ID NO:248,SEQID NO:249,SEQ ID NO:250,SEQ ID NO:251,SEQ ID NO:252,SEQ ID NO:253,SEQ ID NO:254,SEQ ID NO:255,SEQ ID NO:256,SEQ ID NO:257,SEQ ID NO:258,SEQ ID NO:259,SEQID NO:260,SEQ ID NO:261,SEQ ID NO:262,SEQ ID NO:263,SEQ ID NO:264,SEQ ID NO:265,SEQ ID NO:266,SEQ ID NO:267,SEQ ID NO:268,SEQ ID NO:269,SEQ ID NO:270,SEQID NO:271,SEQ ID NO:272,SEQ ID NO:273,SEQ ID NO:274,SEQ ID NO:275,SEQ ID NO:276,SEQ ID NO:277,SEQ ID NO:278,SEQ ID NO:279,SEQ ID NO:280,SEQ ID NO:281,SEQID NO:282,SEQ ID NO:283,SEQ ID NO:284,SEQ ID NO:285,SEQ ID NO:286,SEQ ID NO:287,SEQ ID NO:288,SEQ ID NO:289,SEQ ID NO:290,SEQ ID NO:291,SEQ ID NO:292,SEQID NO:293,SEQ ID NO:294,SEQ ID NO:295,SEQ ID NO:296,SEQ ID NO:297,SEQ ID NO:298,SEQ ID NO:299,SEQ ID NO:300,SEQ ID NO:301,SEQ ID NO:302,SEQ ID NO:303,SEQID NO:304,SEQ ID NO:305,SEQ ID NO:306,SEQ ID NO:307,SEQ ID NO:308,SEQ ID NO:309,SEQ ID NO:310,SEQ ID NO:311,SEQ ID NO:312,SEQ ID NO:313,SEQ ID NO:314,SEQID NO:315,SEQ ID NO:316,SEQ ID NO:317,SEQ ID NO:318,SEQ ID NO:319,SEQ ID NO:320,SEQ ID NO:321,SEQ ID NO:322,SEQ ID NO:323,SEQ ID NO:324,SEQ ID NO:325,SEQID NO:326,SEQ ID NO:327,SEQ ID NO:328,SEQ ID NO:329,SEQ ID NO:330,SEQ ID NO:331,SEQ ID NO:332,SEQ ID NO:333,SEQ ID NO:334,SEQ ID NO:335,SEQ ID NO:336,SEQID NO:337,SEQ ID NO:338,SEQ ID NO:339,SEQ ID NO:340,SEQ ID NO:341,SEQ ID NO:342,SEQ ID NO:343,SEQ ID NO:344,SEQ ID NO:345,SEQ ID NO:346,SEQ ID NO:347,SEQID NO:348,SEQ ID NO:349,SEQ ID NO:350,SEQ ID NO:351,SEQ ID NO:352,SEQ ID NO:353,SEQ ID NO:354,SEQ ID NO:355,SEQ ID NO:356,SEQ ID NO:357,SEQ ID NO:358,SEQID NO:359,SEQ ID NO:360,SEQ ID NO:361,SEQ ID NO:362,SEQ ID NO:363,SEQ ID NO:364,SEQ ID NO:365,SEQ ID NO:366,SEQ ID NO:367,SEQ ID NO:368,SEQ ID NO:369,SEQID NO:370,SEQ ID NO:371,SEQ ID NO:372,SEQ ID NO:373,SEQ ID NO:374,SEQ ID NO:375,SEQ ID NO:376,SEQ ID NO:377,SEQ ID NO:378,SEQ ID NO:379,SEQ ID NO:380,orSEQ ID NO:381.
本公开还提供了一种可变结构域序列,其包含与选自以下的序列至少80%、至少85%、至少90%或至少95%相同的序列:SEQ ID NO:5、SEQ ID NO:6、SEQ ID NO:7、SEQ IDNO:8、SEQ ID NO:9,SEQ ID NO:10,SEQ ID NO:11,SEQ ID NO:12,SEQ ID NO:13,SEQ IDNO:14,SEQ ID NO:15,SEQ ID NO:16,SEQ ID NO:17,SEQ ID NO:18,SEQ ID NO:19,SEQ IDNO:20,SEQ ID NO:21,SEQ ID NO:22,SEQ ID NO:23,SEQ ID NO:24,SEQ ID NO:25,SEQ IDNO:26,SEQ ID NO:27,SEQ ID NO:28,SEQ ID NO:29,SEQ ID NO:30,SEQ ID NO:31,SEQ IDNO:32,SEQ ID NO:33,SEQ ID NO:34,SEQ ID NO:35,SEQ ID NO:36,SEQ ID NO:37,SEQ IDNO:38,SEQ ID NO:39,SEQ ID NO:40,SEQ ID NO:41,SEQ ID NO:42,SEQ ID NO:43,SEQ IDNO:44,SEQ ID NO:45,SEQ ID NO:46,SEQ ID NO:47,SEQ ID NO:48,SEQ ID NO:49,SEQ IDNO:50,SEQ ID NO:51,SEQ ID NO:52,SEQ ID NO:53,SEQ ID NO:54,SEQ ID NO:55,SEQ IDNO:56,SEQ ID NO:57,SEQ ID NO:58,SEQ ID NO:59,SEQ ID NO:60,SEQ ID NO:61,SEQ IDNO:62,SEQ ID NO:63,SEQ ID NO:64,SEQ ID NO:65,SEQ ID NO:66,SEQ ID NO:67,SEQ IDNO:68,SEQ ID NO:69,SEQ ID NO:70,SEQ ID NO:71,SEQ ID NO:72,SEQ ID NO:73,SEQ IDNO:74,SEQ ID NO:75,SEQ ID NO:76,SEQ ID NO:77,SEQ ID NO:78,SEQ ID NO:79,SEQ IDNO:80,SEQ ID NO:81,SEQ ID NO:82,SEQ ID NO:83,SEQ ID NO:84,SEQ ID NO:85,SEQ IDNO:86,SEQ ID NO:87,SEQ ID NO:88,SEQ ID NO:89,SEQ ID NO:90,SEQ ID NO:91,SEQ IDNO:92,SEQ ID NO:93,SEQ ID NO:94,SEQ ID NO:95,SEQ ID NO:96,SEQ ID NO:97,SEQ IDNO:98,SEQ ID NO:99,SEQ ID NO:100,SEQ ID NO:101,SEQ ID NO:102,SEQ ID NO:103,SEQ ID NO:104,SEQ ID NO:105,SEQ ID NO:106,SEQ ID NO:107,SEQ ID NO:108,SEQ IDNO:109,SEQ ID NO:110,SEQ ID NO:111,SEQ ID NO:112,SEQ ID NO:113,SEQ ID NO:114,SEQ ID NO:115,SEQ ID NO:116,SEQ ID NO:117,SEQ ID NO:118,SEQ ID NO:119,SEQ IDNO:120,SEQ ID NO:121,SEQ ID NO:122,SEQ ID NO:123,SEQ ID NO:124,SEQ ID NO:125,SEQ ID NO:126,SEQ ID NO:127,SEQ ID NO:128,SEQ ID NO:129,SEQ ID NO:130,SEQ IDNO:131,SEQ ID NO:132,SEQ ID NO:133,SEQ ID NO:134,SEQ ID NO:135,SEQ ID NO:136,SEQ ID NO:137,SEQ ID NO:138,SEQ ID NO:139,SEQ ID NO:140,SEQ ID NO:141,SEQ IDNO:142,SEQ ID NO:143,SEQ ID NO:144,SEQ ID NO:145,SEQ ID NO:146,SEQ ID NO:147,SEQ ID NO:148,SEQ ID NO:149,SEQ ID NO:150,SEQ ID NO:151,SEQ ID NO:152,SEQ IDNO:153,SEQ ID NO:154,SEQ ID NO:155,SEQ ID NO:156,SEQ ID NO:157,SEQ ID NO:158,SEQ ID NO:159,SEQ ID NO:160,SEQ ID NO:161,SEQ ID NO:162,SEQ ID NO:163,SEQ IDNO:164,SEQ ID NO:165,SEQ ID NO:166,SEQ ID NO:167,SEQ ID NO:168,SEQ ID NO:169,SEQ ID NO:170,SEQ ID NO:171,SEQ ID NO:172,SEQ ID NO:173,SEQ ID NO:174,SEQ IDNO:175,SEQ ID NO:176,SEQ ID NO:177,SEQ ID NO:178,SEQ ID NO:179,SEQ ID NO:180,SEQ ID NO:181,SEQ ID NO:182,SEQ ID NO:183,SEQ ID NO:184,SEQ ID NO:185,SEQ IDNO:186,SEQ ID NO:187,SEQ ID NO:188,SEQ ID NO:189,SEQ ID NO:190,or SEQ ID NO:191.本公开还提供了一种可变结构域序列,其包含与选自以下的序列至少80%、至少85%、至少90%或至少95%相同的序列:SEQ ID NO:192、SEQ ID NO:193、SEQ ID NO:194、SEQ IDNO:195、SEQ ID NO:196,SEQ ID NO:197,SEQ ID NO:198,SEQ ID NO:199,SEQ ID NO:200,SEQ ID NO:201,SEQ ID NO:202,SEQ ID NO:203,SEQ ID NO:204,SEQ ID NO:205,SEQ IDNO:206,SEQ ID NO:207,SEQ ID NO:208,SEQ ID NO:209,SEQ ID NO:210,SEQ ID NO:211,SEQ ID NO:212,SEQ ID NO:213,SEQ ID NO:214,SEQ ID NO:215,SEQ ID NO:216,SEQ IDNO:217,SEQ ID NO:218,SEQ ID NO:219,SEQ ID NO:220,SEQ ID NO:221,SEQ ID NO:222,SEQ ID NO:223,SEQ ID NO:224,SEQ ID NO:225,SEQ ID NO:226,SEQ ID NO:227,SEQ IDNO:228,SEQ ID NO:229,SEQ ID NO:230,SEQ ID NO:231,SEQ ID NO:232,SEQ ID NO:233,SEQ ID NO:234,SEQ ID NO:235,SEQ ID NO:236,SEQ ID NO:237,SEQ ID NO:238,SEQ IDNO:239,SEQ ID NO:240,SEQ ID NO:241,SEQ ID NO:242,SEQ ID NO:243,SEQ ID NO:244,SEQ ID NO:245,SEQ ID NO:246,SEQ ID NO:247,SEQ ID NO:248,SEQ ID NO:249,SEQ IDNO:250,SEQ ID NO:251,SEQ ID NO:252,SEQ ID NO:253,SEQ ID NO:254,SEQ ID NO:255,SEQ ID NO:256,SEQ ID NO:257,SEQ ID NO:258,SEQ ID NO:259,SEQ ID NO:260,SEQ IDNO:261,SEQ ID NO:262,SEQ ID NO:263,SEQ ID NO:264,SEQ ID NO:265,SEQ ID NO:266,SEQ ID NO:267,SEQ ID NO:268,SEQ ID NO:269,SEQ ID NO:270,SEQ ID NO:271,SEQ IDNO:272,SEQ ID NO:273,SEQ ID NO:274,SEQ ID NO:275,SEQ ID NO:276,SEQ ID NO:277,SEQ ID NO:278,SEQ ID NO:279,SEQ ID NO:280,SEQ ID NO:281,SEQ ID NO:282,SEQ IDNO:283,SEQ ID NO:284,SEQ ID NO:285,SEQ ID NO:286,SEQ ID NO:287,SEQ ID NO:288,SEQ ID NO:289,SEQ ID NO:290,SEQ ID NO:291,SEQ ID NO:292,SEQ ID NO:293,SEQ IDNO:294,SEQ ID NO:295,SEQ ID NO:296,SEQ ID NO:297,SEQ ID NO:298,SEQ ID NO:299,SEQ ID NO:300,SEQ ID NO:301,SEQ ID NO:302,SEQ ID NO:303,SEQ ID NO:304,SEQ IDNO:305,SEQ ID NO:306,SEQ ID NO:307,SEQ ID NO:308,SEQ ID NO:309,SEQ ID NO:310,SEQ ID NO:311,SEQ ID NO:312,SEQ ID NO:313,SEQ ID NO:314,SEQ ID NO:315,SEQ IDNO:316,SEQ ID NO:317,SEQ ID NO:318,SEQ ID NO:319,SEQ ID NO:320,SEQ ID NO:321,SEQ ID NO:322,SEQ ID NO:323,SEQ ID NO:324,SEQ ID NO:325,SEQ ID NO:326,SEQ IDNO:327,SEQ ID NO:328,SEQ ID NO:329,SEQ ID NO:330,SEQ ID NO:331,SEQ ID NO:332,SEQ ID NO:333,SEQ ID NO:334,SEQ ID NO:335,SEQ ID NO:336,SEQ ID NO:337,SEQ IDNO:338,SEQ ID NO:339,SEQ ID NO:340,SEQ ID NO:341,SEQ ID NO:342,SEQ ID NO:343,SEQ ID NO:344,SEQ ID NO:345,SEQ ID NO:346,SEQ ID NO:347,SEQ ID NO:348,SEQ IDNO:349,SEQ ID NO:350,SEQ ID NO:351,SEQ ID NO:352,SEQ ID NO:353,SEQ ID NO:354,SEQ ID NO:355,SEQ ID NO:356,SEQ ID NO:357,SEQ ID NO:358,SEQ ID NO:359,SEQ IDNO:360,SEQ ID NO:361,SEQ ID NO:362,SEQ ID NO:363,SEQ ID NO:364,SEQ ID NO:365,SEQ ID NO:366,SEQ ID NO:367,SEQ ID NO:368,SEQ ID NO:369,SEQ ID NO:370,SEQ IDNO:371,SEQ ID NO:372,SEQ ID NO:373,SEQ ID NO:374,SEQ ID NO:375,SEQ ID NO:376,SEQ ID NO:377,SEQ ID NO:378,SEQ ID NO:379,SEQ ID NO:380,or SEQ ID NO:381.
本公开还提供了以下抗体:其包含与SEQ ID NO:35至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:296至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:77至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:278至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:175至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:353至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:97至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:354至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:142至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:356至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:131至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:337至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQID NO:173至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:361至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:47至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:345至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:19至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:296至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:37至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:297至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:105至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:235至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:21至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:262至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:94至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:201至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:21至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ IDNO:260至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:93至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:248至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:80至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:281至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:56至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:197至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:62至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:206至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:50至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:295至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:10至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:296至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:172至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:244至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:115至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:307至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:29至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:296至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:104至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:310至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:12至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:296至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:143至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:234至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:133至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:230至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:185至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:371至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:5至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:274至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:152至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:266至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:152至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:338至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:171至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:245至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:31至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ IDNO:297至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:174至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:358至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:21至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:342至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:27至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:250至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:119至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:202至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:124至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:309至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:135至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:212至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:111至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:237至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:125至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:362至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:81至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:276至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:121至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:381至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:54至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:261至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:101至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:242至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQID NO:116至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:290至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:106至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:235至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:44至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:240至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:187至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:378至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:89至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:268至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:48至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:299至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:8至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:259至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:75至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:228至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:51至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:297至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:46至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:343至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:76至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:289至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:59至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:195至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:25至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:369至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:110至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:267至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:24至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:368至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:147至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:317至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:44至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:249至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:134至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ IDNO:216至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:136至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:226至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:189至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:308至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:78至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:277至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:32至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:297至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQID NO:13至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:296至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:13至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:291至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:83至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:287至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:23至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:258至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:150至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:327至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:71至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:196至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:157至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:223至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQID NO:66至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:224至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:30至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:297至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:118至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:194至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:155至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:324至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:43至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:293至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:140至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:359至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:146至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:321至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:23至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:264至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:17至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:292至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:127至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:331至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQID NO:23至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:257至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:191至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:315至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:22至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:255至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:42至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:263至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:61至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:198至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:33至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:297至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:178至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:232至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:130至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:210至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:85至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:279至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:40至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:258至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:95至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:200至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:108至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:238至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:65至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:193至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:49至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:296至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:20至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:251至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:87至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:334至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:162至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:346至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:161至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ IDNO:366至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:64至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:208至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:64至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:326至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:21至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:252至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:141至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:356至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:21至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:256至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:70至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:207至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:153至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:328至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:122至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:269至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:156至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:311至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:84至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ IDNO:284至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:159至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:367至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:153至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:323至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:128至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:213至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:67至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:227至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:92至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:241至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:21至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:236至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:23至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ IDNO:229至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:166至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:363至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:11至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:300至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:15至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:297至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:103至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:319至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQID NO:69至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:205至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:53至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:263至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:183至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:375至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:9至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:265至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:16至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:303至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:183至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:341至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:55至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:261至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:190至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ IDNO:377至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:23至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:254至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:176至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:379至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQID NO:34至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:314至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:154至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:335至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:160至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:273至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:102至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:218至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:102至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:320至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:158至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:308至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:5至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:272至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQID NO:79至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:286至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:74至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:285至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:180至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:373至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQID NO:18至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:296至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:182至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:372至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:113至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:332至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:57至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:204至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:26至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:260至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:26至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:344至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:179至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:203至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:99至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:357至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:91至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:246至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:45至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:250至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:52至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:294至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:41至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:260至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQID NO:177至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:380至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:28至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:302至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:112至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:233至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:163至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:351至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:6至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:192至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:164至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:365至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:183至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:374至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQID NO:21至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:253至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:60至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:222至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:126至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:220至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:72至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:247至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:169至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:271至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:88至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:322至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:168至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:273至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:184至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ IDNO:347至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:50至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:260至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:138至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:352至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQID NO:109至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:239至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:40至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:262至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:188至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:306至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:129至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:337至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:144至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:221至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:103至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:318至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:100至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:301至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:63至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:336至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:27至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:254至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:14至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:298至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:117至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:316至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:181至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:349至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:153至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:329至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:120至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:340至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:21至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ IDNO:373至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:181至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:348至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:86至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:282至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:98至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:360至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:58至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:199至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:38至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:313至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:68至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:219至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:107至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:238至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:132至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:231至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:137至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:214至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:98至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:217至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:114至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:217至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:90至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:243至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:7至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:225至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:7至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:376至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:186至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:370至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:39至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:270至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:145至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:355至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:139至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:356至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:64至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:209至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:123至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:312至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:36至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:305至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:148至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:266至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:148至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:339至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开还提供了以下抗体:其包含与SEQ ID NO:16至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:304至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:16至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:192至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:73至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:283至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:151至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:325至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:149至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:337至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:149至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:211至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:151至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:215至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:83至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:280至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ IDNO:167至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQID NO:275至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:83至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:288至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:165至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:364至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:82至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:282至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:163至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:350至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:170至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:330至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。本公开还提供了以下抗体:其包含与SEQ ID NO:96至少80%、至少85%、至少90%或至少95%相同的重链可变结构域序列,以及与SEQ ID NO:333至少80%、至少85%、至少90%或至少95%相同的轻链可变结构域序列。
本公开所提供的抗体经过适当的人源化后,可用于通过阻断S蛋白与人血管紧张素转换酶2(huACE2)的结合来治疗和预防SARS-CoV-2感染。研究表明,此类结合事件是病毒进入细胞并繁殖的多步过程的一部分(Hoffmann等人,2020)。本公开所提供的抗体经过适当的人源化后,可用于为一线医护人员提供被动免疫以预防感染。
关于发现和开发本领域内众所周知的针对SARS-CoV-2S蛋白的抗体疗法,请参见第10,975,139号美国专利,其描述了发现和开发针对SARS-CoV-2的抗体疗法,其全部内容通过引用并入本文。
药物组合物
还考虑了包含本公开的抗体或抗体片段的药物组合物,并且其可用于本公开所披露的方法。
药物组合物可包含本公开所述的一种或多种抗体或抗体片段以及药学上可接受的载体或赋形剂。尽管载体或赋形剂可促进用药,但其本身不应诱导产生对接受该组合物的受试者或个体有害的抗体;也不应有毒。合适的载体可以是较大、代谢缓慢的大分子,例如蛋白质、多肽、脂质体、多糖、聚乳酸、聚乙醇酸、聚氨基酸、氨基酸共聚物和无活性的病毒颗粒,并且是本领域技术人员已知的。
本公开所述的抗体或抗原结合片段或本公开所披露的药物组合物可通过多种途径用药,包括但不限于口服、静脉内、肌内、动脉内、髓内、腹膜内、鞘内、心室内、透皮、经皮、局部、皮下、鼻内、肠内、舌下、阴道内或直肠途径。通常情况下,治疗组合物可制备成可注射的液体溶液或悬浮液。也可制备成适于在注射前溶解或悬浮在液体溶媒中的固体形式。
在一个实施例中,抗体或其抗原结合片段或药物组合物通过静脉用药。在另一个实施例中,抗体或其抗原结合片段或药物组合物通过静脉输注用药。
组合物的直接递送通常通过注射、皮下、腹膜内、静脉内或肌肉内完成,或者递送至组织间隙。组合物也可递送至病变部位中。
剂量治疗可以是单剂量用药法或多剂量用药法。已知基于抗体的药物提供了关于用药频率的指南,例如,药物是否应该每日、每周、每月等用药。频率和剂量也可能取决于症状的严重程度。
应当理解,组合物中的活性成分将是抗体分子、抗体片段或其变体和衍生物。因此,其易于在胃肠道中降解。因此,如果组合物通过胃肠道途径用药,则其将需要含有能保护抗体免于降解但在胃肠道中被吸收后就会释放抗体的制剂。
本公开的方法可使用如上所述的抗体或其抗原结合片段,该抗体或其抗原结合片段可单独使用或与其它药物活性化合物进行组合使用,来治疗诸如上文所述的疾病。附加药物活性化合物可以同时用药(以相同或不同的剂型)或按顺序用药。因此,在一个实施例中,本公开包括通过向受试者施用治疗上有效量的本公开抗体或其抗原结合片段以及一种或多种额外药物活性化合物来治疗疾病的方法。
表1提供了本公开所述SARS-CoV-2S蛋白特异性抗体的总结:
实施例
提出以下实施例是为了向本领域普通技术人员提供关于如何制作和使用本公开的完整描述,不旨在限制发明人所认为的其公开内容的范围,也不旨在表示以下实验是可以进行的全部或唯一实验。我们已努力确保所用数字的准确性(如数量、温度等),但也应考虑到一些实验误差和偏差。
除非另有说明,否则份数是指重量的份数,分子量是指重量平均分子量,温度是指摄氏度,压力是指大气压或接近大气压。
实施例1:鼠抗SARS-CoV-2S蛋白抗体免疫的分离和单细胞悬浮液的产生
重组SARS-CoV-2S1蛋白(His标签,目录号:40591-V08H,Sino Biological,中国北京,SEQ ID NO:2)用于免疫年轻CD-1小鼠,每只小鼠在Sigma Adjuvant系统(Sigma-Aldrich,密苏里州圣路易斯)中使用抗体溶液(加利福尼亚州圣克拉拉)的快速免疫方案,使用80μg蛋白免疫35天。在第35天收获淋巴结。产生淋巴结的单细胞悬浮液,并使用70μm网(BD Bioscience)过滤悬浮液以清除团块。
浆细胞分离、抗体捕获和抗原询问
使用基于CD138(Miltenyi,加利福尼亚州奥本)的细胞表面表达的试剂盒对过滤后的淋巴细胞悬浮液进行富集,以获得活跃分泌IgG的浆细胞。使用第9,328,172号美国专利描述的方法,将新鲜富集的血浆细胞沉积到PDMS器械上,以允许单细胞沉积到器械的微孔中。将每个血浆细胞分泌的抗体捕获到衍生的显微镜载玻片上。通过使用不同浓度的以His(ACROBiosystems,中国北京,目录号:SPN-C52H4,SEQ ID NO:3)标记的荧光标记全长SARS-CoV-2S蛋白来询问抗体捕获载玻片,并使用His标记的(Sino Biological,中国北京,目录号:40150-V08B1,SEQ ID NO:4)SARS-CoV Spike/S1蛋白进行反向筛选来识别抗原特异性抗体分泌细胞,以检测潜在广谱可识别抗体和/或中和抗体。使用试剂盒(AnaSpec,加利福尼亚州佛瑞蒙,AS-72046,AnaTagTM HiLyteTM Fluor 555微量蛋白标记试剂盒*超方便*)进行标记。
mRNA捕获
抗体捕获后,除去培养基,使用裂解缓冲液作为代替,然后用定制寡核苷酸微阵列(Agilent,加利福尼亚州圣克拉拉)迅速封闭微孔顶部。此过程之前在第9,328,172号美国专利中有所描述。制备定制寡核苷酸微阵列,使得每个特征不仅包含指定其坐标的独特标签,还包含用于鼠IgG重链、鼠Igκ轻链所有亚类(1、2a、2b和3)的捕获探针。
cDNA合成、PCR扩增和下一代测序
进一步处理在定制微阵列上捕获的mRNA,以合成每个mRNA的cDNA,其中包括每个特征上原有的独特标签。
然后使用Taq聚合酶(Promega,威斯康辛州麦迪逊)和合适的引物组来扩增cDNA,以便扩增下列基因:IgG重链亚类的可变结构域和Igκ轻链的可变结构域。虽然现在将每个基因的这些片段从细胞中释放出来,但是它们都用定制寡核苷酸微阵列的独特标签进行标记,表明其起始位置。进一步操作扩增子以在两端连接合适的序列,从而能够在SeqMaticLLC(加利福尼亚州佛瑞蒙)的Illumina MiSeq仪器上使用2 x 250bp化学(长度)进行测序。
图像和DNA序列的生物信息学分析
处理来自MiSeq的测序读数,识别每个读数中嵌入的标签并将其转换成坐标。
绘制坐标以产生所回收mRNA的合成图。大多数坐标形成簇,为回收的mRNA序列指定起源细胞的位置。接下来,根据与通过适当荧光标记的第二抗体显现的抗体斑点位置相匹配的簇,鉴定和比较存在于每个坐标读数中的CDR3基序。将给定抗体斑点中相同或几乎相同的CDR3组织起来,并形成一致的VH和VL序列对。鉴定含有经鉴定CDR3的VH或VL序列的剩余部分,将相关测序读数组装成VH和VL的全长cDNA序列。与每个抗原特异性抗体斑点相关的亲和力测量值与这对全长cDNA相关联。
实施例2:抗SARS-CoV-2S抗体的分子重建和重组表达
服务提供商根据已知技术将成对VH和VL抗SARS-CoV-2S抗体序列用于合成相应的基因片段将所得基因片段克隆到合适的质粒载体中,并转染到合适的哺乳动物宿主(如HEK293)中,用于重组表达以产生全IgG形式的抗体制剂。通过在OD280测量以评估产生的量,并通过PAGE上的凝胶电泳以评估产生的抗体链大小,从而表征抗体制剂。
实施例3:重组抗SARS-CoV-2S抗体的表征
通过本领域已知的方法,重组表达抗SARS-CoV-2S抗体的选择亚组,并用于在生物膜层干涉(BLI)仪器(如Octet RED96e)上评估抗体对His标记的重组SARS-CoV-2S1蛋白(目录号:40591-V08H,中国北京Sino Biological,SEQ ID NO:2)和His标记的重组全长SARS-CoV-2S蛋白(中国北京ACROBiosystems,目录号:SPN-C52H4,SEQ ID NO:3)的亲和力。针对上述2种蛋白质的亲和力测量结果如表2所示。
实施例4:患者血浆中SARS-CoV-2S蛋白的ELISA分析
将开发一种检测患者血浆中SARS-CoV-2S蛋白的ELISA检测方法。简而言之,将使用来自本公开的第一种预定抗SARS-CoV-2S蛋白抗体作为捕获抗体来对96孔聚苯乙烯微孔板进行包被。
然后将板用含0.01% Tween 20的PBS洗涤6次,用含0.01% Tween 20的PBS中的BSA在37℃封闭1至3小时,用含0.01% Tween 20的PBS洗涤。将来自患者的100μL血浆加入96孔聚苯乙烯微孔板的每个孔中。
然后将于室温下对该混合物孵育两小时。在使用标准技术进行辣根过氧化物酶-酶缀合后,将使用来自本公开的第二种预定抗SARS-CoV-2S蛋白抗体来检测SARS-CoV-2S蛋白,该抗体与第一种预定抗SARS-CoV-2S蛋白抗体具有不同的表位。将板孵育12个小时。然后用含有0.01% Tween 20的PBS将孔洗涤6次。加入100单位基质用于显色,并在持续摇动下孵育15至30min。然后用15μL氯化钠终止反应,再用450nm的波长读取板。将使用已知量的重组SARS-CoV-2S蛋白的系列稀释液来生成标准曲线。
实施例5:用于检测SARS-CoV-2的横向流动免疫测定器械
以下检测旨在通过横流装置上配置的免疫层析测试来检测患者标本中的病毒抗原。
可以检测来自疑似感染SARS-CoV-2患者的人血清样本。可以使用20μL的血清样本。施加样本30s后,将施加100μL的PBS缓冲液(0.01M磷酸盐缓冲液、0.0027M氯化钾和0.137M氯化钠,pH7.4)。样本将移动穿过加样区、结合垫,并通过硝酸纤维素带,直至捕获区。将允许检测显色或反应30min,然后对其进行目视分析,即,两条红线,一条在条带顶部,另一条在下部(分别为对照线和测试线),显示由本公开所披露的抗体检测到存在的病毒抗原。
表2
使用本领域已知的方法,通过BLI检测进行表位鉴定,以进一步表征重组表达抗SARS-CoV-2S抗体的亚组。表位区段图如图1所示。
通过使用代表D614G变体的SARS-CoV-2报告病毒颗粒制剂(RVP,IntegralMolecular,美国宾夕法尼亚州费城)来评估其中和活性,进一步表征重组表达抗SARS-CoV-2S抗体的亚组。RVP是复制缺陷型假型病毒颗粒,能够安全地进行病毒感染性和中和检测。这些RVP携带作为报告基因的荧光素酶,感染合适的宿主细胞(用人ACE2基因构建体稳定转染的稳定293细胞)将显示生物发光。
能够阻止RVP进入宿主细胞的抗体不会显示任何信号。此类中和检测的结果如图2所示。
本公开列出了从上述抗体活动中回收的抗体。本公开所述的抗SARS-CoV-2S抗体的CDR序列及VH和VL序列分别在表3和表4中描述。
表3
表4
上文仅说明了本公开的原理。应当理解,本领域的技术人员将能够设计出各种排列,虽然本文没有明确对其进行描述或示出,但是其体现了本公开的原理,并且在本公开的原理的精神和范围之内。此外,本公开所述的所有实施例和条件语言主要旨在帮助读者理解本公开的原理和发明人为促进本技术所贡献的概念,并且应解释为不限于该等具体叙述的实施例和条件。此外,描述本公开的原理、方面和实施例及其具体示例的所有陈述旨在涵盖其结构和功能等同物。此外,此类等同物旨在包括当前已知等同物和将来开发的等同物,即,所开发执行相同功能的任何元素,而无论其结构如何。因此,本公开的范围并非旨在仅限于本公开所示及所述的示例性实施例。相反,本公开的范围和精神由所附权利要求来体现。
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序列表
<110> 单细胞科技公司
北京百普赛斯生物科技股份有限公司
<120> 抗 SARS-CoV-2刺突蛋白抗体
<130> SCT0013-401-PC
<150> US 63/015,037
<151> 2020-04-24
<160> 784
<170> PatentIn 版本 3.5
<210> 1
<211> 1273
<212> PRT
<213> SARS-CoV-2
<400> 1
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val
1 5 10 15
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe
20 25 30
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu
35 40 45
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp
50 55 60
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp
65 70 75 80
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu
85 90 95
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser
100 105 110
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile
115 120 125
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr
130 135 140
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr
145 150 155 160
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu
165 170 175
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe
180 185 190
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr
195 200 205
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu
210 215 220
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr
225 230 235 240
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser
245 250 255
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro
260 265 270
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala
275 280 285
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys
290 295 300
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val
305 310 315 320
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys
325 330 335
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala
340 345 350
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu
355 360 365
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro
370 375 380
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe
385 390 395 400
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly
405 410 415
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys
420 425 430
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn
435 440 445
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe
450 455 460
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys
465 470 475 480
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly
485 490 495
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val
500 505 510
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys
515 520 525
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn
530 535 540
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu
545 550 555 560
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val
565 570 575
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe
580 585 590
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val
595 600 605
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile
610 615 620
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser
625 630 635 640
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val
645 650 655
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala
660 665 670
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala
675 680 685
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser
690 695 700
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile
705 710 715 720
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val
725 730 735
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu
740 745 750
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr
755 760 765
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln
770 775 780
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe
785 790 795 800
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser
805 810 815
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly
820 825 830
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp
835 840 845
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu
850 855 860
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly
865 870 875 880
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile
885 890 895
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr
900 905 910
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn
915 920 925
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala
930 935 940
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn
945 950 955 960
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val
965 970 975
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln
980 985 990
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val
995 1000 1005
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn
1010 1015 1020
Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys
1025 1030 1035
Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro
1040 1045 1050
Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val
1055 1060 1065
Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His
1070 1075 1080
Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn
1085 1090 1095
Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln
1100 1105 1110
Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val
1115 1120 1125
Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro
1130 1135 1140
Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn
1145 1150 1155
His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn
1160 1165 1170
Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu
1175 1180 1185
Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu
1190 1195 1200
Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu
1205 1210 1215
Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met
1220 1225 1230
Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys
1235 1240 1245
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro
1250 1255 1260
Val Leu Lys Gly Val Lys Leu His Tyr Thr
1265 1270
<210> 2
<211> 681
<212> PRT
<213> 人工序列
<220>
<223> SARS-CoV-2 S蛋白S1亚基His标签蛋白序列
<400> 2
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser
1 5 10 15
Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val
20 25 30
Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr
35 40 45
Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe
50 55 60
Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr
65 70 75 80
Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp
85 90 95
Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val
100 105 110
Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val
115 120 125
Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val
130 135 140
Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe
145 150 155 160
Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu
165 170 175
Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His
180 185 190
Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu
195 200 205
Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln
210 215 220
Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser
225 230 235 240
Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln
245 250 255
Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp
260 265 270
Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu
275 280 285
Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg
290 295 300
Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu
305 310 315 320
Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr
325 330 335
Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val
340 345 350
Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser
355 360 365
Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser
370 375 380
Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr
385 390 395 400
Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly
405 410 415
Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly
420 425 430
Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro
435 440 445
Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro
450 455 460
Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr
465 470 475 480
Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val
485 490 495
Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro
500 505 510
Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe
515 520 525
Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe
530 535 540
Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala
545 550 555 560
Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser
565 570 575
Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln
580 585 590
Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala
595 600 605
Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly
610 615 620
Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His
625 630 635 640
Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys
645 650 655
Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ala His
660 665 670
His His His His His His His His His
675 680
<210> 3
<211> 1216
<212> PRT
<213> 人工序列
<220>
<223> SARS-CoV-2全长S蛋白His标签蛋白序列
<400> 3
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser
1 5 10 15
Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val
20 25 30
Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr
35 40 45
Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe
50 55 60
Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr
65 70 75 80
Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp
85 90 95
Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val
100 105 110
Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val
115 120 125
Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val
130 135 140
Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe
145 150 155 160
Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu
165 170 175
Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His
180 185 190
Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu
195 200 205
Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln
210 215 220
Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser
225 230 235 240
Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln
245 250 255
Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp
260 265 270
Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu
275 280 285
Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg
290 295 300
Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu
305 310 315 320
Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr
325 330 335
Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val
340 345 350
Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser
355 360 365
Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser
370 375 380
Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr
385 390 395 400
Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly
405 410 415
Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly
420 425 430
Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro
435 440 445
Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro
450 455 460
Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr
465 470 475 480
Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val
485 490 495
Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro
500 505 510
Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe
515 520 525
Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe
530 535 540
Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala
545 550 555 560
Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser
565 570 575
Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln
580 585 590
Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala
595 600 605
Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly
610 615 620
Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His
625 630 635 640
Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys
645 650 655
Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Ala Ala Ala Ser Val
660 665 670
Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn
675 680 685
Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr
690 695 700
Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser
705 710 715 720
Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn
725 730 735
Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu
740 745 750
Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala
755 760 765
Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly
770 775 780
Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg
785 790 795 800
Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala
805 810 815
Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg
820 825 830
Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro
835 840 845
Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala
850 855 860
Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln
865 870 875 880
Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val
885 890 895
Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe
900 905 910
Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser
915 920 925
Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu
930 935 940
Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser
945 950 955 960
Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val
965 970 975
Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr
980 985 990
Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn
995 1000 1005
Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys
1010 1015 1020
Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro
1025 1030 1035
Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val
1040 1045 1050
Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His
1055 1060 1065
Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn
1070 1075 1080
Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln
1085 1090 1095
Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val
1100 1105 1110
Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro
1115 1120 1125
Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn
1130 1135 1140
His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn
1145 1150 1155
Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu
1160 1165 1170
Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu
1175 1180 1185
Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Gly Gly Gly Ser Gly
1190 1195 1200
Gly Gly Ser His His His His His His His His His His
1205 1210 1215
<210> 4
<211> 665
<212> PRT
<213> 人工序列
<220>
<223> SARS-CoV S蛋白S1亚基His标签蛋白序列
<400> 4
Ser Asp Leu Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn
1 5 10 15
Tyr Thr Gln His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu
20 25 30
Ile Phe Arg Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro
35 40 45
Phe Tyr Ser Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Asp
50 55 60
Asn Pro Val Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu
65 70 75 80
Lys Ser Asn Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn
85 90 95
Lys Ser Gln Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile
100 105 110
Arg Ala Cys Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser
115 120 125
Lys Pro Met Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe
130 135 140
Asn Cys Thr Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser
145 150 155 160
Glu Lys Ser Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn
165 170 175
Lys Asp Gly Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val
180 185 190
Val Arg Asp Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys
195 200 205
Leu Pro Leu Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala
210 215 220
Phe Ser Pro Ala Gln Asp Thr Trp Gly Thr Ser Ala Ala Ala Tyr Phe
225 230 235 240
Val Gly Tyr Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn
245 250 255
Gly Thr Ile Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu
260 265 270
Leu Lys Cys Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln
275 280 285
Thr Ser Asn Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro
290 295 300
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys
305 310 315 320
Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val
325 330 335
Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys
340 345 350
Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn
355 360 365
Val Tyr Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile
370 375 380
Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro
385 390 395 400
Asp Asp Phe Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp
405 410 415
Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His
420 425 430
Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser
435 440 445
Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro
450 455 460
Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro
465 470 475 480
Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr
485 490 495
Val Cys Gly Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val
500 505 510
Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser
515 520 525
Ser Lys Arg Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp
530 535 540
Phe Thr Asp Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile
545 550 555 560
Ser Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn
565 570 575
Ala Ser Ser Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp
580 585 590
Val Ser Thr Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile
595 600 605
Tyr Ser Thr Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile
610 615 620
Gly Ala Glu His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly
625 630 635 640
Ala Gly Ile Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ala His
645 650 655
His His His His His His His His His
660 665
<210> 5
<211> 118
<212> PRT
<213> 小鼠
<400> 5
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly
20 25 30
Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
35 40 45
Met Gly Tyr Ile Ser Tyr Asp Asp Ser Asn Ser Tyr Asn Pro Ser Leu
50 55 60
Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65 70 75 80
Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Arg Gln Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 6
<211> 116
<212> PRT
<213> 小鼠
<400> 6
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly
20 25 30
Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
35 40 45
Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65 70 75 80
Leu Lys Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Thr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
100 105 110
Thr Val Ser Ser
115
<210> 7
<211> 118
<212> PRT
<213> 小鼠
<400> 7
Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Arg Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Phe Ser Ile Asn Ser Asp
20 25 30
Cys Tyr Trp Ile Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Tyr
35 40 45
Ile Gly Tyr Thr Phe Tyr Ser Gly Ile Thr Tyr Tyr Asn Pro Ser Leu
50 55 60
Glu Ser Arg Thr Tyr Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Ile Thr Thr Arg Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 8
<211> 120
<212> PRT
<213> 小鼠
<400> 8
Glu Val Lys Phe Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Gly Val Ala Ser Gly Phe Thr Phe Asn Asn Tyr
20 25 30
Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Leu Lys Ser Asp Asn Tyr Ala Thr His Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Val Asp Trp Glu Glu Trp Tyr Phe Asp Val Trp Gly Thr
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 9
<211> 118
<212> PRT
<213> 小鼠
<400> 9
Glu Val Lys Ile Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala Lys Asn His Ala Thr Asp Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Thr Val Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 10
<211> 119
<212> PRT
<213> 小鼠
<400> 10
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gly Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr
85 90 95
Tyr Cys Thr Arg Arg Val Thr Ser Gly Gly Asp Tyr Trp Gly Arg Gly
100 105 110
Asn Ser Val Thr Val Ser Ser
115
<210> 11
<211> 119
<212> PRT
<213> 小鼠
<400> 11
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Ile Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr
85 90 95
Tyr Cys Ile Arg Arg Val Thr Ser Gly Gly Asp Tyr Trp Gly Arg Gly
100 105 110
Asn Ser Val Thr Val Ser Ser
115
<210> 12
<211> 119
<212> PRT
<213> 小鼠
<400> 12
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Asn
65 70 75 80
Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Ile Tyr
85 90 95
Tyr Cys Thr Arg Arg Val Thr Ser Gly Gly Asp Tyr Trp Gly Arg Gly
100 105 110
Asn Ser Val Thr Val Ser Ser
115
<210> 13
<211> 119
<212> PRT
<213> 小鼠
<400> 13
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Ile Tyr
85 90 95
Tyr Cys Thr Arg Arg Val Thr Ser Gly Gly Asp Tyr Trp Gly Arg Gly
100 105 110
Asn Ser Val Thr Val Ser Ser
115
<210> 14
<211> 119
<212> PRT
<213> 小鼠
<400> 14
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Cys Ala Glu
50 55 60
Ser Val Lys Gly Ser Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Gly Leu Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Ser Val Thr Val Ser Ser
115
<210> 15
<211> 119
<212> PRT
<213> 小鼠
<400> 15
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Glu Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Ser Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Gly Leu Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Ser Val Thr Val Ser Ser
115
<210> 16
<211> 119
<212> PRT
<213> 小鼠
<400> 16
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Gln Leu Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 17
<211> 119
<212> PRT
<213> 小鼠
<400> 17
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ala
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Ser His Leu Ser Gly Ile Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 18
<211> 118
<212> PRT
<213> 小鼠
<400> 18
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile
35 40 45
Thr Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Lys Gly Leu Ser Phe Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 19
<211> 120
<212> PRT
<213> 小鼠
<400> 19
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Ala Met Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Ser Lys Leu Thr Gly Pro Asn Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 20
<211> 118
<212> PRT
<213> 小鼠
<400> 20
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala His Asn His Ala Thr Asp Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Thr Val Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 21
<211> 118
<212> PRT
<213> 小鼠
<400> 21
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala Lys Asn His Ala Thr Asp Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Thr Val Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 22
<211> 118
<212> PRT
<213> 小鼠
<400> 22
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala Lys Asn Gln Ala Thr Asn Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Ile Trp Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 23
<211> 118
<212> PRT
<213> 小鼠
<400> 23
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Thr Asp Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Thr Val Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 24
<211> 118
<212> PRT
<213> 小鼠
<400> 24
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala Tyr Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Pro Asn Trp Asp Val Val Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 25
<211> 118
<212> PRT
<213> 小鼠
<400> 25
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala Tyr Thr His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Pro Asn Trp Asp Val Val Asp Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 26
<211> 118
<212> PRT
<213> 小鼠
<400> 26
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Gly Lys Asn Tyr Ala Thr Asp Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Thr Val Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 27
<211> 118
<212> PRT
<213> 小鼠
<400> 27
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Met Arg Asn Lys Ala Asn Asn His Ala Thr Asp Tyr Gly Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Thr Val Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 28
<211> 119
<212> PRT
<213> 小鼠
<400> 28
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Lys Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Pro Leu Ser Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Ser Val Thr Val Ser Ser
115
<210> 29
<211> 119
<212> PRT
<213> 小鼠
<400> 29
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Lys Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Pro Leu Ser Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Ser Val Thr Val Ser Ser
115
<210> 30
<211> 119
<212> PRT
<213> 小鼠
<400> 30
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Gly
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Ser His Leu Thr Gly Ile Phe Asp Tyr Trp Gly Gln Ala
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 31
<211> 119
<212> PRT
<213> 小鼠
<400> 31
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Ser Ser His Leu Thr Gly Ile Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 32
<211> 119
<212> PRT
<213> 小鼠
<400> 32
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Ser His Leu Thr Gly Ile Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 33
<211> 119
<212> PRT
<213> 小鼠
<400> 33
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Ser His Leu Thr Trp Ile Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 34
<211> 119
<212> PRT
<213> 小鼠
<400> 34
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Tyr Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Phe Cys Thr Arg Gly Ile Thr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 35
<211> 119
<212> PRT
<213> 小鼠
<400> 35
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Asn Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Gly Ile Thr Tyr Phe Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 36
<211> 118
<212> PRT
<213> 小鼠
<400> 36
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Thr Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Leu Gly Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 37
<211> 119
<212> PRT
<213> 小鼠
<400> 37
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Val Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Ser His Leu Thr Gly Ile Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 38
<211> 119
<212> PRT
<213> 小鼠
<400> 38
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Val Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Gly Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Gly Leu Ser Tyr Thr Met Asp Ser Trp Gly Gln Gly
100 105 110
Thr Ser Val Thr Val Ser Ser
115
<210> 39
<211> 119
<212> PRT
<213> 小鼠
<400> 39
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Thr Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Gln Leu Ala Gly Thr Arg Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 40
<211> 118
<212> PRT
<213> 小鼠
<400> 40
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Thr Asp Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Thr Val Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 41
<211> 118
<212> PRT
<213> 小鼠
<400> 41
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Ala Trp Val
35 40 45
Ala His Ile Arg Leu Lys Ser Asp Asn Tyr Ala Thr His Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Gly His Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 42
<211> 118
<212> PRT
<213> 小鼠
<400> 42
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala His Ile Arg Leu Lys Ser Asp Asn Tyr Ala Thr His Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Gly His Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 43
<211> 119
<212> PRT
<213> 小鼠
<400> 43
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Arg Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr
85 90 95
Tyr Cys Ile Arg Gly Leu Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Ser Val Thr Val Ser Ser
115
<210> 44
<211> 118
<212> PRT
<213> 小鼠
<400> 44
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Tyr Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala Lys Asn His Ala Thr Asp Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Thr Val Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 45
<211> 118
<212> PRT
<213> 小鼠
<400> 45
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Val Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Met Arg Asn Lys Ala Asn Asn His Ala Thr Asp Tyr Gly Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Thr Val Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 46
<211> 118
<212> PRT
<213> 小鼠
<400> 46
Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser
1 5 10 15
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Asn Tyr Asp Gly Ile Ser Thr Phe Tyr Leu Asp Ser Leu
50 55 60
Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Ala Ala Gln Ala Leu Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 47
<211> 118
<212> PRT
<213> 小鼠
<400> 47
Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser
1 5 10 15
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Asn Tyr Asp Gly Ser Ser Ile Tyr Tyr Leu Asp Ser Leu
50 55 60
Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Ala Ala Gln Ala Leu Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 48
<211> 119
<212> PRT
<213> 小鼠
<400> 48
Glu Val Lys Pro Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Ala Ser His Leu Thr Gly Ile Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 49
<211> 118
<212> PRT
<213> 小鼠
<400> 49
Glu Val Lys Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Ser Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Leu Gly Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 50
<211> 118
<212> PRT
<213> 小鼠
<400> 50
Glu Val Lys Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Leu Gly Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 51
<211> 119
<212> PRT
<213> 小鼠
<400> 51
Glu Val Lys Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Gly Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Gly Leu Ser Tyr Thr Met Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Ser Val Thr Val Ser Ser
115
<210> 52
<211> 119
<212> PRT
<213> 小鼠
<400> 52
Glu Val Lys Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Gly Ile Thr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 53
<211> 118
<212> PRT
<213> 小鼠
<400> 53
Glu Val Lys Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala His Ile Arg Leu Lys Ser Asp Asn Tyr Ala Thr His Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Gly His Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 54
<211> 118
<212> PRT
<213> 小鼠
<400> 54
Glu Val Asn Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala Lys Asn His Ala Thr Asp Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Thr Val Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 55
<211> 118
<212> PRT
<213> 小鼠
<400> 55
Glu Val Asn Leu Glu Glu Ser Gly Gly Val Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala Lys Asn His Ala Thr Asp Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Thr Val Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 56
<211> 120
<212> PRT
<213> 小鼠
<400> 56
Glu Val Gln Leu Leu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Tyr Ile Lys Asp Asp
20 25 30
Ser Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Glu Ser Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Thr Leu Pro Leu Tyr Tyr Asp Tyr Val Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 57
<211> 120
<212> PRT
<213> 小鼠
<400> 57
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Glu Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Glu Pro Asp Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Thr Leu Ile Tyr Tyr Tyr Gly Ser Ala Ser Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 58
<211> 120
<212> PRT
<213> 小鼠
<400> 58
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Ile His Trp Met Lys Leu Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Glu Lys Ala Val Thr Glu Tyr Ala Ser Arg Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Leu Pro Leu Tyr Tyr Asp Tyr Pro Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 59
<211> 121
<212> PRT
<213> 小鼠
<400> 59
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Ile His Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Ala Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Asn Phe Gly Ser Ser Gln Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 60
<211> 121
<212> PRT
<213> 小鼠
<400> 60
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Asp Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr His Tyr Gly Ser Ser Tyr Ala Phe Tyr Ala Leu Asp Cys Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 61
<211> 121
<212> PRT
<213> 小鼠
<400> 61
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Gly Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Asn Tyr Gly Ser Ser Gln Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 62
<211> 120
<212> PRT
<213> 小鼠
<400> 62
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Asp Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Thr Leu Ile Tyr Tyr Tyr Gly Ser Cys Ser Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 63
<211> 119
<212> PRT
<213> 小鼠
<400> 63
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Leu Leu Ser Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Gly Asp Ser Asn Tyr Arg Tyr Ala Leu Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Ser Val Thr Val Ser Ser
115
<210> 64
<211> 120
<212> PRT
<213> 小鼠
<400> 64
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Asn Leu Ile Tyr Tyr Tyr Gly Ser Ser Pro Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 65
<211> 121
<212> PRT
<213> 小鼠
<400> 65
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Thr Trp Gly Tyr Thr Asn Tyr Val Glu Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 66
<211> 121
<212> PRT
<213> 小鼠
<400> 66
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Thr Tyr Gly Ser Ser Tyr Val Tyr Tyr Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 67
<211> 120
<212> PRT
<213> 小鼠
<400> 67
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Asn Leu Leu Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 68
<211> 119
<212> PRT
<213> 小鼠
<400> 68
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ser Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Gly Asp Ser Asn Tyr Arg Tyr Ala Leu Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Ser Val Thr Val Ser Ser
115
<210> 69
<211> 120
<212> PRT
<213> 小鼠
<400> 69
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Met Asn Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Thr Leu Ile Tyr Tyr Tyr Gly Ser Cys Pro Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 70
<211> 120
<212> PRT
<213> 小鼠
<400> 70
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Tyr Ile Lys Asp Asp
20 25 30
Tyr Leu His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Glu Asn Gly Asp Ala Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Thr Leu Ile Tyr Tyr Tyr Gly Ser Asn Ser Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 71
<211> 121
<212> PRT
<213> 小鼠
<400> 71
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Val Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Asn Ser Gly Ser Ser Gln Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 72
<211> 114
<212> PRT
<213> 小鼠
<400> 72
Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Ser Met Asn Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Asn Thr Gly Asp Thr Thr Tyr Asn Gln Arg Phe
50 55 60
Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ala Gly Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
100 105 110
Ser Ala
<210> 73
<211> 117
<212> PRT
<213> 小鼠
<400> 73
Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Trp Asp His Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 74
<211> 117
<212> PRT
<213> 小鼠
<400> 74
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Leu Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Met Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Trp Asp Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 75
<211> 114
<212> PRT
<213> 小鼠
<400> 75
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Ser Met Asn Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Leu
35 40 45
Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Tyr Asn Gln His Phe
50 55 60
Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ala Gly Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
100 105 110
Ser Ala
<210> 76
<211> 117
<212> PRT
<213> 小鼠
<400> 76
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr
20 25 30
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Trp Asp Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 77
<211> 117
<212> PRT
<213> 小鼠
<400> 77
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met Asp Trp Val Lys Gln Ser His Gly Glu Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Val Phe Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Trp Asp Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 78
<211> 117
<212> PRT
<213> 小鼠
<400> 78
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asp Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Trp Asp Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 79
<211> 117
<212> PRT
<213> 小鼠
<400> 79
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Lys Asn Gly Gly Thr Val Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asp Gly Ser Lys Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 80
<211> 117
<212> PRT
<213> 小鼠
<400> 80
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Ile Ile Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Trp Asp Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 81
<211> 117
<212> PRT
<213> 小鼠
<400> 81
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gly Ser Lys Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 82
<211> 117
<212> PRT
<213> 小鼠
<400> 82
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Trp Asp Asn Ala Met Asp Tyr Trp Gly Pro Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 83
<211> 117
<212> PRT
<213> 小鼠
<400> 83
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Trp Asp Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 84
<211> 117
<212> PRT
<213> 小鼠
<400> 84
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Trp Asp Thr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 85
<211> 117
<212> PRT
<213> 小鼠
<400> 85
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Thr Asn Gly Gly Thr Val Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Trp Asp Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 86
<211> 117
<212> PRT
<213> 小鼠
<400> 86
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met Asp Trp Val Lys Gln Ser His Gly Met Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Val Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Asp Trp Asp Asn Ala Met Asp Tyr Trp Gly Pro Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 87
<211> 121
<212> PRT
<213> 小鼠
<400> 87
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Asp Thr Phe Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Met Asp Tyr Tyr Asp Leu His Trp Tyr Phe Asp Val Trp Gly
100 105 110
Thr Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 88
<211> 121
<212> PRT
<213> 小鼠
<400> 88
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly His Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Lys Asn Gly Gly Asn Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Asp Tyr Tyr Asp Leu His Trp Tyr Phe Asp Val Trp Gly
100 105 110
Ser Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 89
<211> 114
<212> PRT
<213> 小鼠
<400> 89
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Gln Met Asn Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Arg Thr Gly Gly Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Ala Lys Ala Thr Leu Thr Val Asp Ile Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ala Gly Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
100 105 110
Ser Ala
<210> 90
<211> 114
<212> PRT
<213> 小鼠
<400> 90
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Ser Met Asn Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Ile Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ala Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
100 105 110
Ser Ala
<210> 91
<211> 114
<212> PRT
<213> 小鼠
<400> 91
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Ser Met Asn Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ala Gly Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
100 105 110
Phe Ala
<210> 92
<211> 114
<212> PRT
<213> 小鼠
<400> 92
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Ser Met Asn Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Ser Thr Gly Thr Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ala Gly Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
100 105 110
Ser Ala
<210> 93
<211> 114
<212> PRT
<213> 小鼠
<400> 93
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Arg Ala Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
100 105 110
Ser Ser
<210> 94
<211> 116
<212> PRT
<213> 小鼠
<400> 94
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Cys
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Thr Gly Gly Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asn Trp Val Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ala
115
<210> 95
<211> 116
<212> PRT
<213> 小鼠
<400> 95
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Ser
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asn Trp Val Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ala
115
<210> 96
<211> 121
<212> PRT
<213> 小鼠
<400> 96
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Gly Tyr Lys Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Asp Tyr Tyr Asp Leu His Trp Tyr Phe Asp Val Trp Gly
100 105 110
Thr Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 97
<211> 118
<212> PRT
<213> 小鼠
<400> 97
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr
65 70 75 80
Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Ile Tyr Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 98
<211> 118
<212> PRT
<213> 小鼠
<400> 98
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Glu Gly Thr Tyr Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 99
<211> 118
<212> PRT
<213> 小鼠
<400> 99
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Ile Tyr Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 100
<211> 116
<212> PRT
<213> 小鼠
<400> 100
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Arg His Gly Thr Arg Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu
100 105 110
Thr Val Ser Ser
115
<210> 101
<211> 120
<212> PRT
<213> 小鼠
<400> 101
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Gly Thr Ala Tyr
65 70 75 80
Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Ser Cys
85 90 95
Ala Arg Ser Tyr Tyr Gly Ser Gln Tyr Gln Leu Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 102
<211> 121
<212> PRT
<213> 小鼠
<400> 102
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Tyr Tyr Phe Ala Leu Tyr Tyr Ser Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 103
<211> 121
<212> PRT
<213> 小鼠
<400> 103
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Tyr Tyr Tyr Ala Leu Tyr Tyr Ser Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 104
<211> 120
<212> PRT
<213> 小鼠
<400> 104
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Tyr Gly Ser Pro Trp Gly Phe Phe Asp Val Trp Gly Thr
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 105
<211> 114
<212> PRT
<213> 小鼠
<400> 105
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asp Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Val Asn Ser Asn Trp Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val
100 105 110
Ser Ser
<210> 106
<211> 114
<212> PRT
<213> 小鼠
<400> 106
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asn Pro Asp Asn Gly Asp Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Val Asn Ser Asn Trp Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val
100 105 110
Ser Ser
<210> 107
<211> 114
<212> PRT
<213> 小鼠
<400> 107
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asn Pro Asp Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Ala Leu Thr Ile Asn Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Val Asn Ser Asn Trp Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val
100 105 110
Ser Ser
<210> 108
<211> 114
<212> PRT
<213> 小鼠
<400> 108
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asn Pro Asp Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Val Asn Ser Asn Trp Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val
100 105 110
Ser Ser
<210> 109
<211> 114
<212> PRT
<213> 小鼠
<400> 109
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asn Pro Asn Asp Gly Gly Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Val Asn Ser Asn Trp Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val
100 105 110
Ser Ser
<210> 110
<211> 114
<212> PRT
<213> 小鼠
<400> 110
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Val Asn Ser Asn Trp Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val
100 105 110
Ser Ser
<210> 111
<211> 114
<212> PRT
<213> 小鼠
<400> 111
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Val
35 40 45
Gly Tyr Ile Asn Pro Asp Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Val Asn Ser Asn Trp Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val
100 105 110
Ser Ser
<210> 112
<211> 114
<212> PRT
<213> 小鼠
<400> 112
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asn Pro Asp Asn Gly Gly Pro Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Met Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Val Asn Ser Asn Trp Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val
100 105 110
Ser Ser
<210> 113
<211> 121
<212> PRT
<213> 小鼠
<400> 113
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Met Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe
50 55 60
Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Met Asp Tyr Tyr Asp Leu Gln Trp Tyr Phe Asp Val Trp Gly
100 105 110
Thr Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 114
<211> 118
<212> PRT
<213> 小鼠
<400> 114
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Tyr Pro Asn Asn Gly Gly Asn Gly Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ala Gly Pro Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 115
<211> 120
<212> PRT
<213> 小鼠
<400> 115
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asn Asn Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Tyr Gly Ser Gly Trp Gly Phe Phe Asp Val Trp Gly Thr
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 116
<211> 116
<212> PRT
<213> 小鼠
<400> 116
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg His Gly Thr Arg Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu
100 105 110
Thr Val Ser Ser
115
<210> 117
<211> 117
<212> PRT
<213> 小鼠
<400> 117
Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Tyr Asn Gly Gly Ala Ser Tyr Ser Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Arg Leu Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 118
<211> 121
<212> PRT
<213> 小鼠
<400> 118
Glu Val Gln Leu Gln Gln Ser Arg Ala Glu Phe Val Arg Pro Gly Ala
1 5 10 15
Ser Val Met Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Asn Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Ala Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Asn Phe Gly Ser Ser Gln Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 119
<211> 119
<212> PRT
<213> 小鼠
<400> 119
Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Pro Ser Gly Phe Asn Ile Lys Asp Thr
20 25 30
Tyr Met His Trp Val Gln Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Ala Asn Gly Tyr Ala Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Asp Ile Tyr Pro Tyr Val Ile Gly Phe Ser Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ala
115
<210> 120
<211> 122
<212> PRT
<213> 小鼠
<400> 120
Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Gly Leu His Trp Val Arg Gln Ala Pro Glu Asn Gly Leu Glu Trp Val
35 40 45
Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Arg Leu Tyr Asp Tyr Asp Val Ser Tyr Ala Met Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 121
<211> 122
<212> PRT
<213> 小鼠
<400> 121
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Arg Val Tyr Asp Phe Asp Val Ser Tyr Ala Met Asp Tyr Trp
100 105 110
Gly Arg Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 122
<211> 119
<212> PRT
<213> 小鼠
<400> 122
Glu Val Gln Pro Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Gln Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Gly Leu Ser Tyr Thr Met Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Ser Val Thr Val Ser Ser
115
<210> 123
<211> 120
<212> PRT
<213> 小鼠
<400> 123
Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Ser Ile His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile
35 40 45
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Thr Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asp Gly Tyr Pro Arg Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 124
<211> 120
<212> PRT
<213> 小鼠
<400> 124
Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Ser Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile
35 40 45
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn His Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ser Val Tyr Phe Cys
85 90 95
Ala Arg Asp Gly Tyr Pro Arg Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 125
<211> 116
<212> PRT
<213> 小鼠
<400> 125
Gln Gly Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Thr Gly Tyr Arg Phe Thr Gly Tyr
20 25 30
Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys
85 90 95
Ala Ser Ser Gly Thr Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
100 105 110
Thr Val Ser Ser
115
<210> 126
<211> 120
<212> PRT
<213> 小鼠
<400> 126
Gln Gly Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Trp Ile Val Trp Ala Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Glu Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Ser Lys Gly Leu Thr Gly Thr Leu Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 127
<211> 118
<212> PRT
<213> 小鼠
<400> 127
Gln Ile Gln Phe Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Val Tyr Thr Phe Thr Glu Tyr
20 25 30
Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Trp Ile His Thr Tyr Ser Gly Glu Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Trp Arg Phe Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 128
<211> 122
<212> PRT
<213> 小鼠
<400> 128
Gln Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Leu Ile Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Pro Tyr Phe Cys
85 90 95
Val Arg Gly Gly Tyr Gly Asn Tyr Val Arg Trp Tyr Phe Asp Val Trp
100 105 110
Gly Thr Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 129
<211> 118
<212> PRT
<213> 小鼠
<400> 129
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Gly Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Gly Arg Asp Asp Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 130
<211> 122
<212> PRT
<213> 小鼠
<400> 130
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Glu Tyr Thr Leu Thr Glu Tyr
20 25 30
Leu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Met Ile Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Val Arg Gly Gly Tyr Gly Asn Tyr Val Arg Trp Tyr Phe Asp Val Trp
100 105 110
Gly Thr Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 131
<211> 118
<212> PRT
<213> 小鼠
<400> 131
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Thr Tyr
20 25 30
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Ala Gly Val Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Lys Tyr Phe Cys
85 90 95
Thr Arg Asp Asp Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 132
<211> 114
<212> PRT
<213> 小鼠
<400> 132
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Met Ile Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Val Arg Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
100 105 110
Ser Ser
<210> 133
<211> 113
<212> PRT
<213> 小鼠
<400> 133
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Ala Met His Gly Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Met Ile Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Val Asn Ser Asn Leu Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser
100 105 110
Ser
<210> 134
<211> 122
<212> PRT
<213> 小鼠
<400> 134
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Leu Met His Trp Val Lys Gln Ala Pro Gly Lys Asp Phe Lys Trp Met
35 40 45
Gly Met Thr Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Val Arg Gly Gly Tyr Gly Asn Tyr Val Arg Trp Tyr Phe Asp Val Trp
100 105 110
Gly Thr Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 135
<211> 122
<212> PRT
<213> 小鼠
<400> 135
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Leu Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Met Ile Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Leu Cys
85 90 95
Val Arg Gly Gly Tyr Gly Asn Tyr Val Arg Trp Tyr Phe Asp Val Trp
100 105 110
Gly Thr Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 136
<211> 116
<212> PRT
<213> 小鼠
<400> 136
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Pro Met His Trp Met Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Met Ile Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Arg Asp Tyr Gly Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val
100 105 110
Thr Val Ser Ser
115
<210> 137
<211> 122
<212> PRT
<213> 小鼠
<400> 137
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Asp Phe Lys Trp Met
35 40 45
Gly Met Thr Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Glu Asp Ser
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Thr Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Val Arg Gly Gly Tyr Gly Asn Tyr Val Arg Trp Tyr Phe Asp Val Trp
100 105 110
Gly Thr Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 138
<211> 118
<212> PRT
<213> 小鼠
<400> 138
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Leu Ile Tyr Ser Asp Thr Gly Glu Pro Thr His Ala Glu Glu Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Val Arg Gly Glu Asn Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 139
<211> 118
<212> PRT
<213> 小鼠
<400> 139
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Leu Ile Tyr Thr Asp Thr Gly Asp Pro Thr Tyr Ala Glu Glu Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ser Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Val Arg Gly Glu Asn Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 140
<211> 118
<212> PRT
<213> 小鼠
<400> 140
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Leu Ile Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Glu Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Val Arg Gly Glu Asn Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 141
<211> 118
<212> PRT
<213> 小鼠
<400> 141
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Leu Ile Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Val Arg Gly Glu Asn Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 142
<211> 118
<212> PRT
<213> 小鼠
<400> 142
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Met Ile Tyr Ser Asp Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Arg Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Val Arg Gly Glu Asn Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 143
<211> 116
<212> PRT
<213> 小鼠
<400> 143
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Met Ile Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asp Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Val Arg Glu Gly Ser Ser Pro Asp Tyr Trp Gly Gln Gly Thr Thr Leu
100 105 110
Thr Val Ser Ser
115
<210> 144
<211> 116
<212> PRT
<213> 小鼠
<400> 144
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Met Ile Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Val Arg Ser Arg Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu
100 105 110
Thr Val Ser Ser
115
<210> 145
<211> 118
<212> PRT
<213> 小鼠
<400> 145
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
35 40 45
Gly Met Ile Tyr Thr Asp Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Val Arg Gly Glu Asn Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Pro Leu Thr Val Ser Ser
115
<210> 146
<211> 118
<212> PRT
<213> 小鼠
<400> 146
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe
20 25 30
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ser Thr Tyr Phe Cys
85 90 95
Ala Arg Asp Asp Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 147
<211> 118
<212> PRT
<213> 小鼠
<400> 147
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe
20 25 30
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Ala Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Asp Asp Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 148
<211> 119
<212> PRT
<213> 小鼠
<400> 148
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Phe Ser Gly Val Ala Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Ser Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Asn Trp Asp Trp Tyr Phe Asp Val Trp Gly Thr Gly
100 105 110
Thr Thr Val Thr Val Ser Ser
115
<210> 149
<211> 118
<212> PRT
<213> 小鼠
<400> 149
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Lys Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ser Arg Asp Asp Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 150
<211> 118
<212> PRT
<213> 小鼠
<400> 150
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Asp Asp Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 151
<211> 118
<212> PRT
<213> 小鼠
<400> 151
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Asp Asp Asp Tyr Glu Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 152
<211> 119
<212> PRT
<213> 小鼠
<400> 152
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Asn Trp Asp Trp Tyr Phe Asp Val Trp Gly Thr Gly
100 105 110
Thr Thr Val Thr Val Ser Ser
115
<210> 153
<211> 118
<212> PRT
<213> 小鼠
<400> 153
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ser Arg Asp Asp Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 154
<211> 118
<212> PRT
<213> 小鼠
<400> 154
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Ile Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Asp Asp Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 155
<211> 118
<212> PRT
<213> 小鼠
<400> 155
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Leu
35 40 45
Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Asp Asp Gly Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Asp Asp Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 156
<211> 117
<212> PRT
<213> 小鼠
<400> 156
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
1 5 10 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
20 25 30
Ala Ile Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Ile Ile Trp Thr Thr Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala
85 90 95
Arg Asn Trp Val Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 157
<211> 121
<212> PRT
<213> 小鼠
<400> 157
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
1 5 10 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn
20 25 30
Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Thr Gly Gly Gly Ile Asn Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Glu Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala
85 90 95
Arg Trp Asp Tyr Tyr Tyr Gly Ser Arg Trp Tyr Phe Asp Val Trp Gly
100 105 110
Thr Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 158
<211> 117
<212> PRT
<213> 小鼠
<400> 158
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
1 5 10 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Ile Ile Trp Thr Thr Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala
85 90 95
Arg Asn Trp Val Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 159
<211> 117
<212> PRT
<213> 小鼠
<400> 159
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
1 5 10 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr
20 25 30
Gly Ile His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Ser Gly Gly Ser Thr Tyr Tyr Asn Ala Ala Phe Ile
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Ile Ser Lys Ser Gln Val Phe Phe
65 70 75 80
Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Thr Tyr Tyr Cys Ala
85 90 95
Ser Pro Lys Trp Asp Asp Ala Leu Asp Tyr Trp Gly Gln Gly Ser Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 160
<211> 114
<212> PRT
<213> 小鼠
<400> 160
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Met Arg Pro Gly Ser
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Tyr Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Ile Thr Gly Thr Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
100 105 110
Ser Ser
<210> 161
<211> 122
<212> PRT
<213> 小鼠
<400> 161
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Trp Met His Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Met Ile His Pro Asn Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Arg Gly Tyr Tyr Ser Asn Tyr Gly Asp Ala Met Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 162
<211> 123
<212> PRT
<213> 小鼠
<400> 162
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Arg Tyr Tyr Gly Ser Arg Arg Asp Trp Tyr Phe Asp Val
100 105 110
Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 163
<211> 122
<212> PRT
<213> 小鼠
<400> 163
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Met Ile His Pro Asn Ser Gly Asn Thr Asn Tyr Asn Ala Lys Phe
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Gly Arg Arg Gly Tyr Tyr Ser Asn Tyr Gly Asp Ala Met Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 164
<211> 122
<212> PRT
<213> 小鼠
<400> 164
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Met Ile His Pro Asn Ser Gly Asn Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Gly Arg Arg Gly Tyr Tyr Ser Asn Tyr Gly Asp Ala Met Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 165
<211> 122
<212> PRT
<213> 小鼠
<400> 165
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Met Ile His Pro Asn Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Gly Arg Arg Gly Phe Tyr Ser Asn Tyr Gly Asp Ala Met Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 166
<211> 122
<212> PRT
<213> 小鼠
<400> 166
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Met Ile His Pro Asn Ser Gly Ser Thr Asn Tyr Asn Glu Lys Leu
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Gly Arg Arg Gly Tyr Tyr Ser Asn Tyr Gly Asp Ala Met Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 167
<211> 114
<212> PRT
<213> 小鼠
<400> 167
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly His Ile Tyr Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Glu Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Ile Thr Gly Thr Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
100 105 110
Ser Ser
<210> 168
<211> 114
<212> PRT
<213> 小鼠
<400> 168
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Tyr Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Ile Thr Gly Thr Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
100 105 110
Ser Ser
<210> 169
<211> 114
<212> PRT
<213> 小鼠
<400> 169
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Tyr Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Ile Thr Gly Thr Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
100 105 110
Ser Ser
<210> 170
<211> 118
<212> PRT
<213> 小鼠
<400> 170
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Ala Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gly Ile Gly Trp Pro Leu Gly His Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 171
<211> 114
<212> PRT
<213> 小鼠
<400> 171
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asn Pro Ser Asp Gly Asp Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
100 105 110
Ser Ser
<210> 172
<211> 114
<212> PRT
<213> 小鼠
<400> 172
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asp Pro Ser Asn Gly Asp Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Gly Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Leu
100 105 110
Ser Ser
<210> 173
<211> 116
<212> PRT
<213> 小鼠
<400> 173
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Ser Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Phe Thr Ala Asp Pro Ser Ser Asn Thr Val Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys
85 90 95
Ala Ser Ser Gly Thr Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
100 105 110
Thr Val Ser Ser
115
<210> 174
<211> 116
<212> PRT
<213> 小鼠
<400> 174
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Trp Leu Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Leu Pro Gly Ser Gly Lys Thr Asn Ser Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys
85 90 95
Ala Ser Ser Gly Thr Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
100 105 110
Thr Val Ser Ser
115
<210> 175
<211> 116
<212> PRT
<213> 小鼠
<400> 175
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Trp Val Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Leu Pro Gly Ser Gly Ser Ser Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Val Asn
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys
85 90 95
Ala Ser Ser Gly Thr Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val
100 105 110
Thr Val Ser Ser
115
<210> 176
<211> 113
<212> PRT
<213> 小鼠
<400> 176
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Arg Asp
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Gln Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser
100 105 110
Ser
<210> 177
<211> 113
<212> PRT
<213> 小鼠
<400> 177
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Arg Tyr
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Val Gln Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser
100 105 110
Ser
<210> 178
<211> 114
<212> PRT
<213> 小鼠
<400> 178
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Phe
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Asn Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val
100 105 110
Ser Ser
<210> 179
<211> 120
<212> PRT
<213> 小鼠
<400> 179
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Ser
20 25 30
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Arg Ile Arg Asp Tyr Gly Thr Ser Val Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 180
<211> 118
<212> PRT
<213> 小鼠
<400> 180
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asp Gly Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asp Phe Gly Pro Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 181
<211> 117
<212> PRT
<213> 小鼠
<400> 181
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60
Lys Gly Glu Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Tyr Gly Ser Arg Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr
100 105 110
Val Thr Val Ser Ser
115
<210> 182
<211> 118
<212> PRT
<213> 小鼠
<400> 182
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asp Phe Gly Pro Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 183
<211> 117
<212> PRT
<213> 小鼠
<400> 183
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Arg Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr
100 105 110
Val Thr Val Ser Ser
115
<210> 184
<211> 117
<212> PRT
<213> 小鼠
<400> 184
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Tyr Gly Ser Arg Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr
100 105 110
Val Thr Val Ser Ser
115
<210> 185
<211> 118
<212> PRT
<213> 小鼠
<400> 185
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Glu Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asp Phe Gly Pro Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 186
<211> 118
<212> PRT
<213> 小鼠
<400> 186
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Arg Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Ala Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asp Phe Gly Pro Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr
100 105 110
Thr Val Ser Val Ser Ser
115
<210> 187
<211> 117
<212> PRT
<213> 小鼠
<400> 187
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30
Trp Met Thr Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60
Glu Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ala Leu Trp Leu Pro Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 188
<211> 117
<212> PRT
<213> 小鼠
<400> 188
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asn Asp Tyr Asp Glu Gly Glu Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 189
<211> 117
<212> PRT
<213> 小鼠
<400> 189
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Tyr Ser
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Ser Gly Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asn Asp Tyr Asp Glu Gly Glu Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 190
<211> 117
<212> PRT
<213> 小鼠
<400> 190
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Val Phe Ser Ser Ser
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Tyr Gly Ser Arg Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr
100 105 110
Val Thr Val Ser Ser
115
<210> 191
<211> 121
<212> PRT
<213> 小鼠
<400> 191
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Ser Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val
65 70 75 80
Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Arg Ala Asn Gly Tyr Tyr Ala Tyr Phe Asp Val Trp Gly
100 105 110
Thr Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 192
<211> 107
<212> PRT
<213> 小鼠
<400> 192
Asp Phe Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Thr Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 193
<211> 107
<212> PRT
<213> 小鼠
<400> 193
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Cys Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Arg
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 194
<211> 106
<212> PRT
<213> 小鼠
<400> 194
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Ile Ser Tyr
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Arg Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 195
<211> 106
<212> PRT
<213> 小鼠
<400> 195
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Asn Tyr
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Arg Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 196
<211> 106
<212> PRT
<213> 小鼠
<400> 196
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Phe
20 25 30
Leu Ile Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Arg Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 197
<211> 107
<212> PRT
<213> 小鼠
<400> 197
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 198
<211> 106
<212> PRT
<213> 小鼠
<400> 198
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Arg Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 199
<211> 107
<212> PRT
<213> 小鼠
<400> 199
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Pro Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Asn Tyr
20 25 30
Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ala Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Ala Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 200
<211> 107
<212> PRT
<213> 小鼠
<400> 200
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
35 40 45
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 201
<211> 107
<212> PRT
<213> 小鼠
<400> 201
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
35 40 45
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 202
<211> 107
<212> PRT
<213> 小鼠
<400> 202
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr
20 25 30
Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Glu Arg Phe Ser Gly
50 55 60
Ser Trp Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 80
Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 203
<211> 107
<212> PRT
<213> 小鼠
<400> 203
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr
20 25 30
Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly
50 55 60
Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 80
Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Cys Ala Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 204
<211> 107
<212> PRT
<213> 小鼠
<400> 204
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr
20 25 30
Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile
35 40 45
His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Arg Asn Leu Glu Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Pro Arg
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 205
<211> 106
<212> PRT
<213> 小鼠
<400> 205
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr
20 25 30
Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile
35 40 45
His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Arg Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 206
<211> 107
<212> PRT
<213> 小鼠
<400> 206
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr
20 25 30
Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile
35 40 45
His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro
65 70 75 80
Glu Asp Ile Val Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Pro Arg
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 207
<211> 107
<212> PRT
<213> 小鼠
<400> 207
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Asn Phe
20 25 30
Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile
35 40 45
His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Gly Gly Ser Gly Arg Asp Tyr Ser Phe Thr Ile Ser Asn Leu Glu Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asp Leu Pro Arg
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 208
<211> 106
<212> PRT
<213> 小鼠
<400> 208
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Asn Tyr
20 25 30
Ile Ala Trp Cys Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile
35 40 45
His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Asn Asn Leu Glu Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 209
<211> 106
<212> PRT
<213> 小鼠
<400> 209
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Asn Tyr
20 25 30
Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile
35 40 45
His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Asn Asn Leu Glu Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 210
<211> 107
<212> PRT
<213> 小鼠
<400> 210
Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser Glu Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ile Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Met Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr
65 70 75 80
Glu Asp Val Ala Ser Tyr Tyr Cys Gln Gln Tyr Trp Asn Ile Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 211
<211> 107
<212> PRT
<213> 小鼠
<400> 211
Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser Val Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Phe Asn Arg
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Ile Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 212
<211> 107
<212> PRT
<213> 小鼠
<400> 212
Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser Val Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Thr Ser Leu Glu Thr Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Asn Ile Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Val Ile Lys
100 105
<210> 213
<211> 107
<212> PRT
<213> 小鼠
<400> 213
Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser Val Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Asn Thr Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 214
<211> 107
<212> PRT
<213> 小鼠
<400> 214
Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser Val Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Asn Ile Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 215
<211> 107
<212> PRT
<213> 小鼠
<400> 215
Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser Val Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Arg
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 216
<211> 107
<212> PRT
<213> 小鼠
<400> 216
Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser Val Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Thr Thr Ser Val Gln Thr
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Asn Thr Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 217
<211> 107
<212> PRT
<213> 小鼠
<400> 217
Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly
1 5 10 15
Gly Arg Val Thr Ile Pro Cys Arg Ala Ser Asp His Ile Asn Asn Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 218
<211> 107
<212> PRT
<213> 小鼠
<400> 218
Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly
1 5 10 15
Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 219
<211> 107
<212> PRT
<213> 小鼠
<400> 219
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Thr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 220
<211> 107
<212> PRT
<213> 小鼠
<400> 220
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Phe
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 221
<211> 107
<212> PRT
<213> 小鼠
<400> 221
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Phe
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Val Asn Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 222
<211> 107
<212> PRT
<213> 小鼠
<400> 222
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Ile Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 223
<211> 107
<212> PRT
<213> 小鼠
<400> 223
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Pro
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 224
<211> 107
<212> PRT
<213> 小鼠
<400> 224
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 225
<211> 107
<212> PRT
<213> 小鼠
<400> 225
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asn Ser Ser Leu Pro Ile Asn Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 226
<211> 107
<212> PRT
<213> 小鼠
<400> 226
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Asn Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 227
<211> 107
<212> PRT
<213> 小鼠
<400> 227
Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Phe
20 25 30
Leu Gly Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Ser Arg Ala Ser Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 228
<211> 111
<212> PRT
<213> 小鼠
<400> 228
Asp Ile Val Leu Thr Gln Ser Leu Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr
20 25 30
Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Val Tyr Phe Cys Gln Gln Ser Arg
85 90 95
Lys Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 229
<211> 111
<212> PRT
<213> 小鼠
<400> 229
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Ile Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 230
<211> 111
<212> PRT
<213> 小鼠
<400> 230
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Leu Ser Leu Gly
1 5 10 15
Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Ile Ile
20 25 30
Gly Thr Asn Leu Ile Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr His Thr Ser Asn Leu Glu Thr Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65 70 75 80
Pro Val Glu Glu Asp Asp Val Ala Ile Tyr Tyr Cys Leu Gln Ser Arg
85 90 95
Lys Ile Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 231
<211> 111
<212> PRT
<213> 小鼠
<400> 231
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Met Ser Leu Gly
1 5 10 15
Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Ile Ile
20 25 30
Gly Ala Asn Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Phe His Ala Ser Asn Leu Glu Thr Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65 70 75 80
Pro Val Glu Glu Asp Asp Val Ala Ile Tyr Tyr Cys Leu Gln Ser Arg
85 90 95
Lys Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 232
<211> 111
<212> PRT
<213> 小鼠
<400> 232
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Met Ser Leu Gly
1 5 10 15
Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Ile Ile
20 25 30
Gly Thr Asn Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Phe His Ala Ser Asn Leu Glu Thr Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65 70 75 80
Pro Val Glu Glu Asp Asp Val Ala Ile Tyr Tyr Cys Leu Gln Ser Lys
85 90 95
Lys Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 233
<211> 111
<212> PRT
<213> 小鼠
<400> 233
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Met Ser Leu Gly
1 5 10 15
Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Ile Ile
20 25 30
Gly Thr Asn Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Phe His Ala Ser Asn Leu Glu Thr Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65 70 75 80
Pro Val Glu Glu Asp Asp Val Ala Ile Tyr Tyr Cys Leu Gln Ser Arg
85 90 95
Lys Ile Pro Tyr Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys
100 105 110
<210> 234
<211> 111
<212> PRT
<213> 小鼠
<400> 234
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Met Ser Leu Gly
1 5 10 15
Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Ile Ile
20 25 30
Gly Thr Asn Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr His Ala Ser Asn Leu Glu Thr Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65 70 75 80
Pro Val Glu Glu Asp Asp Val Ala Ile Tyr Tyr Cys Leu Gln Ser Arg
85 90 95
Lys Ile Pro Cys Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 235
<211> 111
<212> PRT
<213> 小鼠
<400> 235
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Met Ser Leu Gly
1 5 10 15
Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Ile Ile
20 25 30
Gly Thr Asn Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr His Ala Ser Asn Leu Glu Thr Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65 70 75 80
Pro Val Glu Glu Asp Asp Val Ala Ile Tyr Tyr Cys Leu Gln Ser Arg
85 90 95
Lys Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 236
<211> 111
<212> PRT
<213> 小鼠
<400> 236
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Phe Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 237
<211> 111
<212> PRT
<213> 小鼠
<400> 237
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Ile Ile
20 25 30
Gly Ala Asn Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Phe His Ala Ser Asn Leu Glu Thr Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Ile Tyr Phe Cys Leu Gln Ser Arg
85 90 95
Lys Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 238
<211> 111
<212> PRT
<213> 小鼠
<400> 238
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Ile Ile
20 25 30
Gly Ala Asn Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr His Ala Ser Asn Leu Glu Thr Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Ile Tyr Tyr Cys Leu Gln Ser Arg
85 90 95
Lys Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 239
<211> 111
<212> PRT
<213> 小鼠
<400> 239
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Ile Ile
20 25 30
Gly Ala Asn Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr His Ala Ser Asn Leu Glu Thr Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Ile Tyr Tyr Cys Leu Gln Ser Arg
85 90 95
Lys Ile Pro Tyr Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys
100 105 110
<210> 240
<211> 111
<212> PRT
<213> 小鼠
<400> 240
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Lys Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Gly Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Ala Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 241
<211> 111
<212> PRT
<213> 小鼠
<400> 241
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Ala Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr
20 25 30
Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Asp Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg
85 90 95
Lys Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 242
<211> 111
<212> PRT
<213> 小鼠
<400> 242
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp
20 25 30
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Thr Gly Ile Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Thr Asn
85 90 95
Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 243
<211> 111
<212> PRT
<213> 小鼠
<400> 243
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Arg Glu Asn Leu Glu Tyr Tyr
20 25 30
Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg
85 90 95
Lys Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 244
<211> 111
<212> PRT
<213> 小鼠
<400> 244
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Phe Glu Tyr Tyr
20 25 30
Gly Thr Ser Phe Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg
85 90 95
Lys Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 245
<211> 111
<212> PRT
<213> 小鼠
<400> 245
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr
20 25 30
Gly Thr Gly Phe Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile His Ala Ala Ala Asn Val Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg
85 90 95
Lys Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 246
<211> 111
<212> PRT
<213> 小鼠
<400> 246
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr
20 25 30
Gly Thr Ser Leu Leu Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg
85 90 95
Lys Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 247
<211> 111
<212> PRT
<213> 小鼠
<400> 247
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr
20 25 30
Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Asp Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Asp Asp Val Ala Met Tyr Phe Cys Gln Gln Ser Arg
85 90 95
Lys Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 248
<211> 111
<212> PRT
<213> 小鼠
<400> 248
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr
20 25 30
Gly Thr Ser Leu Val Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Thr Arg
85 90 95
Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 249
<211> 111
<212> PRT
<213> 小鼠
<400> 249
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Gly Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Ala Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 250
<211> 111
<212> PRT
<213> 小鼠
<400> 250
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Gly Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 251
<211> 111
<212> PRT
<213> 小鼠
<400> 251
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Asp Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 252
<211> 111
<212> PRT
<213> 小鼠
<400> 252
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 253
<211> 111
<212> PRT
<213> 小鼠
<400> 253
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Phe Met His Trp Tyr His Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 254
<211> 111
<212> PRT
<213> 小鼠
<400> 254
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 255
<211> 111
<212> PRT
<213> 小鼠
<400> 255
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 256
<211> 111
<212> PRT
<213> 小鼠
<400> 256
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 257
<211> 111
<212> PRT
<213> 小鼠
<400> 257
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Val Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 258
<211> 111
<212> PRT
<213> 小鼠
<400> 258
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Tyr Ile His Trp Tyr Gln Gln Gln Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 259
<211> 111
<212> PRT
<213> 小鼠
<400> 259
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Phe Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 260
<211> 111
<212> PRT
<213> 小鼠
<400> 260
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 261
<211> 111
<212> PRT
<213> 小鼠
<400> 261
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Val Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 262
<211> 111
<212> PRT
<213> 小鼠
<400> 262
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Val Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 263
<211> 111
<212> PRT
<213> 小鼠
<400> 263
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Pro Ile Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 264
<211> 111
<212> PRT
<213> 小鼠
<400> 264
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Val Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 265
<211> 111
<212> PRT
<213> 小鼠
<400> 265
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Ser Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
85 90 95
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 266
<211> 107
<212> PRT
<213> 小鼠
<400> 266
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly
1 5 10 15
Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile
35 40 45
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr
65 70 75 80
Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Tyr Ile Trp Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 267
<211> 111
<212> PRT
<213> 小鼠
<400> 267
Asp Ile Val Leu Thr Gln Ser Pro Thr Ser Leu Ala Met Ser Leu Gly
1 5 10 15
Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Ile Ile
20 25 30
Gly Thr Asn Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Phe His Ala Ser Asn Leu Glu Thr Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65 70 75 80
Pro Val Glu Gly Asp Asp Val Ala Ile Tyr Tyr Cys Leu Gln Ser Arg
85 90 95
Lys Ile Pro Tyr Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 268
<211> 111
<212> PRT
<213> 小鼠
<400> 268
Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr
20 25 30
Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Asp Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg
85 90 95
Lys Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 269
<211> 107
<212> PRT
<213> 小鼠
<400> 269
Asp Ile Val Met Ala Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Ala Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 270
<211> 107
<212> PRT
<213> 小鼠
<400> 270
Asp Ile Val Met Thr His Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Val Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 271
<211> 107
<212> PRT
<213> 小鼠
<400> 271
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Asn Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ser Lys
100 105
<210> 272
<211> 107
<212> PRT
<213> 小鼠
<400> 272
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ala Ser Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Asn Leu Glu Leu Lys
100 105
<210> 273
<211> 107
<212> PRT
<213> 小鼠
<400> 273
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 274
<211> 107
<212> PRT
<213> 小鼠
<400> 274
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Thr Ser Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Asn Leu Glu Leu Lys
100 105
<210> 275
<211> 107
<212> PRT
<213> 小鼠
<400> 275
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 276
<211> 113
<212> PRT
<213> 小鼠
<400> 276
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly His Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Asn Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Phe Gly Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp His Arg Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 277
<211> 113
<212> PRT
<213> 小鼠
<400> 277
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser
20 25 30
Gly His Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Ile Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp His Arg Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 278
<211> 113
<212> PRT
<213> 小鼠
<400> 278
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly Asp Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 279
<211> 113
<212> PRT
<213> 小鼠
<400> 279
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly Asp Gln Met His Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 280
<211> 113
<212> PRT
<213> 小鼠
<400> 280
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly His Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Asn
85 90 95
Asp His Arg Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 281
<211> 113
<212> PRT
<213> 小鼠
<400> 281
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly His Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp His Arg Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 282
<211> 113
<212> PRT
<213> 小鼠
<400> 282
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly His Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp His Thr Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 283
<211> 113
<212> PRT
<213> 小鼠
<400> 283
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly Asn Gln Glu Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 284
<211> 113
<212> PRT
<213> 小鼠
<400> 284
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Phe Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 285
<211> 113
<212> PRT
<213> 小鼠
<400> 285
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 286
<211> 113
<212> PRT
<213> 小鼠
<400> 286
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly Tyr Gln Lys Ile Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp His Thr Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 287
<211> 113
<212> PRT
<213> 小鼠
<400> 287
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly Tyr Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp His Arg Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 288
<211> 113
<212> PRT
<213> 小鼠
<400> 288
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Arg Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly His Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Phe Gly Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp His Arg Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 289
<211> 113
<212> PRT
<213> 小鼠
<400> 289
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly His Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp His Arg Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 290
<211> 107
<212> PRT
<213> 小鼠
<400> 290
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Glu Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Phe Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln Tyr Trp Ile Tyr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 291
<211> 107
<212> PRT
<213> 小鼠
<400> 291
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Phe Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys
100 105
<210> 292
<211> 107
<212> PRT
<213> 小鼠
<400> 292
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val His Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 293
<211> 107
<212> PRT
<213> 小鼠
<400> 293
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Phe Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 294
<211> 107
<212> PRT
<213> 小鼠
<400> 294
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ile Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 295
<211> 107
<212> PRT
<213> 小鼠
<400> 295
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Ile Tyr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 296
<211> 107
<212> PRT
<213> 小鼠
<400> 296
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 297
<211> 107
<212> PRT
<213> 小鼠
<400> 297
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 298
<211> 107
<212> PRT
<213> 小鼠
<400> 298
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn
100 105
<210> 299
<211> 107
<212> PRT
<213> 小鼠
<400> 299
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 300
<211> 107
<212> PRT
<213> 小鼠
<400> 300
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 301
<211> 107
<212> PRT
<213> 小鼠
<400> 301
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln Tyr Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 302
<211> 107
<212> PRT
<213> 小鼠
<400> 302
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ser Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 303
<211> 107
<212> PRT
<213> 小鼠
<400> 303
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Thr Leu Ile
35 40 45
Phe Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 304
<211> 107
<212> PRT
<213> 小鼠
<400> 304
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Thr Leu Ile
35 40 45
Phe Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Val Leu Lys
100 105
<210> 305
<211> 107
<212> PRT
<213> 小鼠
<400> 305
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Thr
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 306
<211> 108
<212> PRT
<213> 小鼠
<400> 306
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Phe Asn Ser Tyr Pro Leu
85 90 95
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 307
<211> 107
<212> PRT
<213> 小鼠
<400> 307
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Gly Thr Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Ser Lys Leu Glu Ile Lys
100 105
<210> 308
<211> 108
<212> PRT
<213> 小鼠
<400> 308
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu
85 90 95
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 309
<211> 107
<212> PRT
<213> 小鼠
<400> 309
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 310
<211> 107
<212> PRT
<213> 小鼠
<400> 310
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 311
<211> 108
<212> PRT
<213> 小鼠
<400> 311
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Thr Tyr Pro Leu
85 90 95
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 312
<211> 107
<212> PRT
<213> 小鼠
<400> 312
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Ser Thr Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 313
<211> 107
<212> PRT
<213> 小鼠
<400> 313
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ile Val Arg Thr Ala
20 25 30
Val Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 314
<211> 107
<212> PRT
<213> 小鼠
<400> 314
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Ser Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 315
<211> 107
<212> PRT
<213> 小鼠
<400> 315
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Thr Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 316
<211> 107
<212> PRT
<213> 小鼠
<400> 316
Asp Asn Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 317
<211> 112
<212> PRT
<213> 小鼠
<400> 317
Asp Val Gly Met Thr Gln Thr Pro Leu Ser Leu Pro Val Arg Leu Gly
1 5 10 15
Ala Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 318
<211> 112
<212> PRT
<213> 小鼠
<400> 318
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Val
85 90 95
Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 319
<211> 112
<212> PRT
<213> 小鼠
<400> 319
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Val
85 90 95
Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 320
<211> 112
<212> PRT
<213> 小鼠
<400> 320
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Arg
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Val
85 90 95
Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 321
<211> 112
<212> PRT
<213> 小鼠
<400> 321
Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Phe Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Ile Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 322
<211> 112
<212> PRT
<213> 小鼠
<400> 322
Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Tyr Gly Asp Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 323
<211> 112
<212> PRT
<213> 小鼠
<400> 323
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Thr Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 324
<211> 112
<212> PRT
<213> 小鼠
<400> 324
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Ile Leu Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 325
<211> 112
<212> PRT
<213> 小鼠
<400> 325
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Asn Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 326
<211> 113
<212> PRT
<213> 小鼠
<400> 326
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu His Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 327
<211> 112
<212> PRT
<213> 小鼠
<400> 327
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Ile Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 328
<211> 112
<212> PRT
<213> 小鼠
<400> 328
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Ile Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 329
<211> 112
<212> PRT
<213> 小鼠
<400> 329
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser His Ser
85 90 95
Thr Leu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 330
<211> 112
<212> PRT
<213> 小鼠
<400> 330
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 331
<211> 112
<212> PRT
<213> 小鼠
<400> 331
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 332
<211> 112
<212> PRT
<213> 小鼠
<400> 332
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Tyr Gly Asn Thr Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 333
<211> 112
<212> PRT
<213> 小鼠
<400> 333
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Tyr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 334
<211> 112
<212> PRT
<213> 小鼠
<400> 334
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Tyr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Asn Leu Leu Ile Tyr Lys Val Ser Val Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 335
<211> 112
<212> PRT
<213> 小鼠
<400> 335
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 336
<211> 112
<212> PRT
<213> 小鼠
<400> 336
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Gly
85 90 95
Thr His Ile Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 337
<211> 112
<212> PRT
<213> 小鼠
<400> 337
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 338
<211> 112
<212> PRT
<213> 小鼠
<400> 338
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Ala Ser Phe Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Phe Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
85 90 95
Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 339
<211> 112
<212> PRT
<213> 小鼠
<400> 339
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Ala Ser Phe Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Thr Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
85 90 95
Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 340
<211> 107
<212> PRT
<213> 小鼠
<400> 340
Asn Val Val Leu Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Tyr Asp
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Tyr Ala Phe Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Asn Ser Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 341
<211> 106
<212> PRT
<213> 小鼠
<400> 341
Gln Phe Val Leu Pro Gln Ser Pro Ala Ile Met Pro Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Phe Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 342
<211> 106
<212> PRT
<213> 小鼠
<400> 342
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Ala Cys Arg Ala Ser Ser Ser Ile Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
35 40 45
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ser Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser His Pro Leu Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 343
<211> 106
<212> PRT
<213> 小鼠
<400> 343
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Leu Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Ser Trp Ile Tyr
35 40 45
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ile Pro Phe Thr
85 90 95
Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 344
<211> 106
<212> PRT
<213> 小鼠
<400> 344
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
35 40 45
Ala Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Gly Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 345
<211> 106
<212> PRT
<213> 小鼠
<400> 345
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
35 40 45
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Asn Pro Phe Thr
85 90 95
Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 346
<211> 106
<212> PRT
<213> 小鼠
<400> 346
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
35 40 45
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Leu Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 347
<211> 106
<212> PRT
<213> 小鼠
<400> 347
Gln Ile Val Leu Thr Pro Ser Pro Ala Ile Met Ser Ala His Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Asn Tyr Met
20 25 30
Phe Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 348
<211> 106
<212> PRT
<213> 小鼠
<400> 348
Gln Ile Val Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Phe Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Thr Tyr Pro Pro Thr
85 90 95
Phe Gly Ala Gly Thr Asn Leu Glu Leu Lys
100 105
<210> 349
<211> 106
<212> PRT
<213> 小鼠
<400> 349
Gln Ile Val Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met
20 25 30
Phe Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Tyr Pro Pro Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 350
<211> 106
<212> PRT
<213> 小鼠
<400> 350
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Phe Pro Gly
1 5 10 15
Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Ser Trp Ile Tyr
35 40 45
Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 351
<211> 106
<212> PRT
<213> 小鼠
<400> 351
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Phe Pro Gly
1 5 10 15
Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Ser Trp Ile Tyr
35 40 45
Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 352
<211> 108
<212> PRT
<213> 小鼠
<400> 352
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Leu Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
85 90 95
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 353
<211> 108
<212> PRT
<213> 小鼠
<400> 353
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Phe His Arg Ser Pro
85 90 95
Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 354
<211> 108
<212> PRT
<213> 小鼠
<400> 354
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Phe Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Gln
85 90 95
Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 355
<211> 108
<212> PRT
<213> 小鼠
<400> 355
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
85 90 95
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 356
<211> 108
<212> PRT
<213> 小鼠
<400> 356
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
85 90 95
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 357
<211> 108
<212> PRT
<213> 小鼠
<400> 357
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Gln
85 90 95
Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 358
<211> 108
<212> PRT
<213> 小鼠
<400> 358
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Phe His Arg Ser Pro
85 90 95
Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 359
<211> 108
<212> PRT
<213> 小鼠
<400> 359
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
85 90 95
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 360
<211> 108
<212> PRT
<213> 小鼠
<400> 360
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Thr Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Phe His His Ser Gln
85 90 95
Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 361
<211> 108
<212> PRT
<213> 小鼠
<400> 361
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu Leu Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Phe His Arg Ser Pro
85 90 95
Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 362
<211> 108
<212> PRT
<213> 小鼠
<400> 362
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Tyr Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Phe His Arg Ser Pro
85 90 95
Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 363
<211> 106
<212> PRT
<213> 小鼠
<400> 363
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Ser
35 40 45
Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 364
<211> 106
<212> PRT
<213> 小鼠
<400> 364
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Ser Trp Ile Cys
35 40 45
Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Asn Tyr Pro Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 365
<211> 106
<212> PRT
<213> 小鼠
<400> 365
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Ser Trp Ile Tyr
35 40 45
Arg Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 366
<211> 106
<212> PRT
<213> 小鼠
<400> 366
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Ser Gly Ser Ser Pro Lys Ser Trp Ile His
35 40 45
Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 367
<211> 108
<212> PRT
<213> 小鼠
<400> 367
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
85 90 95
Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 368
<211> 106
<212> PRT
<213> 小鼠
<400> 368
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Arg Ser Asp Ile Asn Tyr Ile
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Phe Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr Tyr Pro Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 369
<211> 106
<212> PRT
<213> 小鼠
<400> 369
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Arg Ser Gly Val Asn Tyr Ile
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Phe Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr Tyr Pro Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 370
<211> 106
<212> PRT
<213> 小鼠
<400> 370
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Glu Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 371
<211> 106
<212> PRT
<213> 小鼠
<400> 371
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Asn Tyr Tyr Pro Trp Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 372
<211> 106
<212> PRT
<213> 小鼠
<400> 372
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Met Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 373
<211> 106
<212> PRT
<213> 小鼠
<400> 373
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Met Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Thr Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Ala Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 374
<211> 106
<212> PRT
<213> 小鼠
<400> 374
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Phe Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Tyr Pro Pro Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 375
<211> 106
<212> PRT
<213> 小鼠
<400> 375
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Phe Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Tyr Pro Pro Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg
100 105
<210> 376
<211> 106
<212> PRT
<213> 小鼠
<400> 376
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 377
<211> 106
<212> PRT
<213> 小鼠
<400> 377
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met
20 25 30
Phe Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 378
<211> 106
<212> PRT
<213> 小鼠
<400> 378
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Thr Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Tyr Pro Leu Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 379
<211> 106
<212> PRT
<213> 小鼠
<400> 379
Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr
35 40 45
Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Phe Thr
85 90 95
Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 380
<211> 106
<212> PRT
<213> 小鼠
<400> 380
Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr
35 40 45
Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 381
<211> 107
<212> PRT
<213> 小鼠
<400> 381
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser His Asp
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Leu Thr Gly
50 55 60
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
Ala Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Phe
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 382
<211> 8
<212> PRT
<213> 小鼠
<400> 382
Gly Phe Thr Phe Ser Asp Ala Trp
1 5
<210> 383
<211> 9
<212> PRT
<213> 小鼠
<400> 383
Ile Arg Asn Lys Ala Asn Asn His Ala
1 5
<210> 384
<211> 10
<212> PRT
<213> 小鼠
<400> 384
Thr Arg Gly Ile Thr Tyr Phe Phe Asp Tyr
1 5 10
<210> 385
<211> 8
<212> PRT
<213> 小鼠
<400> 385
Gly Tyr Thr Phe Thr Asp Tyr Asn
1 5
<210> 386
<211> 7
<212> PRT
<213> 小鼠
<400> 386
Ile Asn Pro Asn Asn Gly Gly
1 5
<210> 387
<211> 10
<212> PRT
<213> 小鼠
<400> 387
Ala Arg Asp Trp Asp Asn Ala Met Asp Tyr
1 5 10
<210> 388
<211> 8
<212> PRT
<213> 小鼠
<400> 388
Gly Tyr Thr Phe Thr Gly Tyr Trp
1 5
<210> 389
<211> 7
<212> PRT
<213> 小鼠
<400> 389
Ile Leu Pro Gly Ser Gly Ser
1 5
<210> 390
<211> 9
<212> PRT
<213> 小鼠
<400> 390
Ala Ser Ser Gly Thr Asp Phe Asp Tyr
1 5
<210> 391
<211> 8
<212> PRT
<213> 小鼠
<400> 391
Gly Tyr Thr Phe Thr Asp Tyr Tyr
1 5
<210> 392
<211> 11
<212> PRT
<213> 小鼠
<400> 392
Ala Arg Glu Gly Ile Tyr Gly Tyr Phe Asp Val
1 5 10
<210> 393
<211> 8
<212> PRT
<213> 小鼠
<400> 393
Gly Tyr Thr Phe Thr Glu Tyr Pro
1 5
<210> 394
<211> 7
<212> PRT
<213> 小鼠
<400> 394
Ile Tyr Ser Asp Thr Gly Glu
1 5
<210> 395
<211> 11
<212> PRT
<213> 小鼠
<400> 395
Val Arg Gly Glu Asn Trp Tyr Tyr Phe Asp Tyr
1 5 10
<210> 396
<211> 8
<212> PRT
<213> 小鼠
<400> 396
Gly Tyr Ile Phe Thr Thr Tyr Gly
1 5
<210> 397
<211> 7
<212> PRT
<213> 小鼠
<400> 397
Ile Asn Thr Tyr Ala Gly Val
1 5
<210> 398
<211> 11
<212> PRT
<213> 小鼠
<400> 398
Thr Arg Asp Asp Asp Tyr Asp Gly Phe Ala Tyr
1 5 10
<210> 399
<211> 8
<212> PRT
<213> 小鼠
<400> 399
Gly Phe Thr Phe Ser Asp Tyr Tyr
1 5
<210> 400
<211> 7
<212> PRT
<213> 小鼠
<400> 400
Ile Asn Tyr Asp Gly Ser Ser
1 5
<210> 401
<211> 11
<212> PRT
<213> 小鼠
<400> 401
Ala Arg Glu Gly Ala Ala Gln Ala Leu Asp Tyr
1 5 10
<210> 402
<211> 9
<212> PRT
<213> 小鼠
<400> 402
Met Arg Asn Lys Ala Asn Asn His Ala
1 5
<210> 403
<211> 11
<212> PRT
<213> 小鼠
<400> 403
Thr Ser Lys Leu Thr Gly Pro Asn Phe Asp Tyr
1 5 10
<210> 404
<211> 10
<212> PRT
<213> 小鼠
<400> 404
Thr Ser His Leu Thr Gly Ile Phe Asp Tyr
1 5 10
<210> 405
<211> 7
<212> PRT
<213> 小鼠
<400> 405
Ile Asp Pro Asn Asn Gly Gly
1 5
<210> 406
<211> 7
<212> PRT
<213> 小鼠
<400> 406
Val Asn Ser Asn Trp Asp Val
1 5
<210> 407
<211> 9
<212> PRT
<213> 小鼠
<400> 407
Ile Arg Asn Lys Ala Lys Asn His Ala
1 5
<210> 408
<211> 9
<212> PRT
<213> 小鼠
<400> 408
Thr Thr Val Gly Tyr Ala Met Asp Tyr
1 5
<210> 409
<211> 8
<212> PRT
<213> 小鼠
<400> 409
Gly Tyr Thr Phe Thr Asp Cys Tyr
1 5
<210> 410
<211> 7
<212> PRT
<213> 小鼠
<400> 410
Ile Asn Pro Asn Thr Gly Gly
1 5
<210> 411
<211> 9
<212> PRT
<213> 小鼠
<400> 411
Ala Ala Asn Trp Val Trp Phe Ala Tyr
1 5
<210> 412
<211> 8
<212> PRT
<213> 小鼠
<400> 412
Gly Tyr Ser Phe Thr Gly Tyr Tyr
1 5
<210> 413
<211> 7
<212> PRT
<213> 小鼠
<400> 413
Ile Asn Pro Ser Thr Gly Gly
1 5
<210> 414
<211> 7
<212> PRT
<213> 小鼠
<400> 414
Ala Arg Gly Arg Ala Asp Tyr
1 5
<210> 415
<211> 8
<212> PRT
<213> 小鼠
<400> 415
Gly Phe Tyr Ile Lys Asp Asp Ser
1 5
<210> 416
<211> 7
<212> PRT
<213> 小鼠
<400> 416
Ile Asp Pro Glu Ser Gly Asp
1 5
<210> 417
<211> 13
<212> PRT
<213> 小鼠
<400> 417
Thr Thr Leu Pro Leu Tyr Tyr Asp Tyr Val Met Asp Tyr
1 5 10
<210> 418
<211> 8
<212> PRT
<213> 小鼠
<400> 418
Gly Phe Asn Ile Lys Asp Asp Tyr
1 5
<210> 419
<211> 7
<212> PRT
<213> 小鼠
<400> 419
Ile Asp Pro Asp Asn Gly Asp
1 5
<210> 420
<211> 13
<212> PRT
<213> 小鼠
<400> 420
Thr Thr Leu Ile Tyr Tyr Tyr Gly Ser Cys Ser Asp Tyr
1 5 10
<210> 421
<211> 8
<212> PRT
<213> 小鼠
<400> 421
Gly Phe Ser Phe Ser Asp Ala Trp
1 5
<210> 422
<211> 9
<212> PRT
<213> 小鼠
<400> 422
Thr Arg Leu Gly Trp Tyr Phe Asp Val
1 5
<210> 423
<211> 10
<212> PRT
<213> 小鼠
<400> 423
Thr Arg Arg Val Thr Ser Gly Gly Asp Tyr
1 5 10
<210> 424
<211> 8
<212> PRT
<213> 小鼠
<400> 424
Gly Tyr Thr Phe Thr Ser Tyr Trp
1 5
<210> 425
<211> 7
<212> PRT
<213> 小鼠
<400> 425
Ile Asp Pro Ser Asn Gly Asp
1 5
<210> 426
<211> 7
<212> PRT
<213> 小鼠
<400> 426
Ala Arg Gly Gly Ser Asp Tyr
1 5
<210> 427
<211> 13
<212> PRT
<213> 小鼠
<400> 427
Ala Arg Asp Tyr Gly Ser Gly Trp Gly Phe Phe Asp Val
1 5 10
<210> 428
<211> 10
<212> PRT
<213> 小鼠
<400> 428
Thr Pro Leu Ser Asn Tyr Ala Met Asp Tyr
1 5 10
<210> 429
<211> 13
<212> PRT
<213> 小鼠
<400> 429
Ala Arg Asp Tyr Gly Ser Pro Trp Gly Phe Phe Asp Val
1 5 10
<210> 430
<211> 7
<212> PRT
<213> 小鼠
<400> 430
Ile Tyr Thr Asp Thr Gly Glu
1 5
<210> 431
<211> 9
<212> PRT
<213> 小鼠
<400> 431
Val Arg Glu Gly Ser Ser Pro Asp Tyr
1 5
<210> 432
<211> 8
<212> PRT
<213> 小鼠
<400> 432
Gly Tyr Thr Phe Thr Glu Tyr Ala
1 5
<210> 433
<211> 6
<212> PRT
<213> 小鼠
<400> 433
Val Asn Ser Asn Leu Val
1 5
<210> 434
<211> 8
<212> PRT
<213> 小鼠
<400> 434
Gly Tyr Ala Phe Ser Ser Ser Trp
1 5
<210> 435
<211> 7
<212> PRT
<213> 小鼠
<400> 435
Ile Tyr Pro Gly Asp Gly Asp
1 5
<210> 436
<211> 11
<212> PRT
<213> 小鼠
<400> 436
Ala Arg Asp Phe Gly Pro Trp Tyr Phe Asp Val
1 5 10
<210> 437
<211> 9
<212> PRT
<213> 小鼠
<400> 437
Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr
1 5
<210> 438
<211> 6
<212> PRT
<213> 小鼠
<400> 438
Ile Ser Tyr Asp Asp Ser
1 5
<210> 439
<211> 11
<212> PRT
<213> 小鼠
<400> 439
Ala Arg Glu Gly Arg Gln Asn Tyr Phe Asp Tyr
1 5 10
<210> 440
<211> 8
<212> PRT
<213> 小鼠
<400> 440
Gly Tyr Thr Phe Thr Thr Tyr Gly
1 5
<210> 441
<211> 7
<212> PRT
<213> 小鼠
<400> 441
Ile Asn Thr Tyr Ser Gly Val
1 5
<210> 442
<211> 12
<212> PRT
<213> 小鼠
<400> 442
Ala Arg Gly Gly Asn Trp Asp Trp Tyr Phe Asp Val
1 5 10
<210> 443
<211> 8
<212> PRT
<213> 小鼠
<400> 443
Gly Tyr Thr Phe Ala Ser Tyr Trp
1 5
<210> 444
<211> 7
<212> PRT
<213> 小鼠
<400> 444
Ile Asn Pro Ser Asp Gly Asp
1 5
<210> 445
<211> 7
<212> PRT
<213> 小鼠
<400> 445
Ala Arg Gly Gly Leu Asp Tyr
1 5
<210> 446
<211> 10
<212> PRT
<213> 小鼠
<400> 446
Ser Ser His Leu Thr Gly Ile Phe Asp Tyr
1 5 10
<210> 447
<211> 7
<212> PRT
<213> 小鼠
<400> 447
Ile Leu Pro Gly Ser Gly Lys
1 5
<210> 448
<211> 8
<212> PRT
<213> 小鼠
<400> 448
Gly Phe Asn Ile Lys Asp Thr Tyr
1 5
<210> 449
<211> 7
<212> PRT
<213> 小鼠
<400> 449
Ile Asp Pro Ala Asn Gly Tyr
1 5
<210> 450
<211> 12
<212> PRT
<213> 小鼠
<400> 450
Ala Asp Ile Tyr Pro Tyr Val Ile Gly Phe Ser Tyr
1 5 10
<210> 451
<211> 8
<212> PRT
<213> 小鼠
<400> 451
Gly Tyr Thr Phe Thr Ser Tyr Ser
1 5
<210> 452
<211> 7
<212> PRT
<213> 小鼠
<400> 452
Ile Tyr Pro Gly Asn Gly Asp
1 5
<210> 453
<211> 13
<212> PRT
<213> 小鼠
<400> 453
Ala Arg Asp Gly Tyr Pro Arg Tyr Tyr Ala Leu Asp Tyr
1 5 10
<210> 454
<211> 8
<212> PRT
<213> 小鼠
<400> 454
Gly Tyr Thr Phe Thr Glu Tyr Leu
1 5
<210> 455
<211> 15
<212> PRT
<213> 小鼠
<400> 455
Val Arg Gly Gly Tyr Gly Asn Tyr Val Arg Trp Tyr Phe Asp Val
1 5 10 15
<210> 456
<211> 7
<212> PRT
<213> 小鼠
<400> 456
Ile Asn Pro Asp Asn Gly Gly
1 5
<210> 457
<211> 8
<212> PRT
<213> 小鼠
<400> 457
Gly Tyr Arg Phe Thr Gly Tyr Trp
1 5
<210> 458
<211> 10
<212> PRT
<213> 小鼠
<400> 458
Ala Arg Asp Gly Ser Lys Ala Met Asp Tyr
1 5 10
<210> 459
<211> 8
<212> PRT
<213> 小鼠
<400> 459
Gly Phe Thr Phe Ser Asp Tyr Gly
1 5
<210> 460
<211> 7
<212> PRT
<213> 小鼠
<400> 460
Ile Ser Ser Gly Ser Ser Thr
1 5
<210> 461
<211> 15
<212> PRT
<213> 小鼠
<400> 461
Ala Arg Arg Val Tyr Asp Phe Asp Val Ser Tyr Ala Met Asp Tyr
1 5 10 15
<210> 462
<211> 13
<212> PRT
<213> 小鼠
<400> 462
Ala Arg Ser Tyr Tyr Gly Ser Gln Tyr Gln Leu Asp Tyr
1 5 10
<210> 463
<211> 9
<212> PRT
<213> 小鼠
<400> 463
Ala Arg His Gly Thr Arg Gly Asp Tyr
1 5
<210> 464
<211> 7
<212> PRT
<213> 小鼠
<400> 464
Ile Asn Pro Asp Asn Gly Asp
1 5
<210> 465
<211> 10
<212> PRT
<213> 小鼠
<400> 465
Ala Arg Ala Leu Trp Leu Pro Phe Asp Tyr
1 5 10
<210> 466
<211> 8
<212> PRT
<213> 小鼠
<400> 466
Gly Tyr Ser Phe Thr Gly Tyr Gln
1 5
<210> 467
<211> 7
<212> PRT
<213> 小鼠
<400> 467
Ile Asn Pro Arg Thr Gly Gly
1 5
<210> 468
<211> 7
<212> PRT
<213> 小鼠
<400> 468
Ala Arg Gly Ala Gly Thr Tyr
1 5
<210> 469
<211> 10
<212> PRT
<213> 小鼠
<400> 469
Ala Ser His Leu Thr Gly Ile Phe Asp Tyr
1 5 10
<210> 470
<211> 8
<212> PRT
<213> 小鼠
<400> 470
Gly Phe Thr Phe Asn Asn Tyr Trp
1 5
<210> 471
<211> 9
<212> PRT
<213> 小鼠
<400> 471
Ile Arg Leu Lys Ser Asp Asn Tyr Ala
1 5
<210> 472
<211> 11
<212> PRT
<213> 小鼠
<400> 472
Thr Val Asp Trp Glu Glu Trp Tyr Phe Asp Val
1 5 10
<210> 473
<211> 8
<212> PRT
<213> 小鼠
<400> 473
Gly Tyr Ser Phe Thr Gly Tyr Ser
1 5
<210> 474
<211> 10
<212> PRT
<213> 小鼠
<400> 474
Thr Arg Gly Leu Ser Tyr Thr Met Asp Tyr
1 5 10
<210> 475
<211> 7
<212> PRT
<213> 小鼠
<400> 475
Ile Asn Tyr Asp Gly Ile Ser
1 5
<210> 476
<211> 8
<212> PRT
<213> 小鼠
<400> 476
Gly Phe Thr Phe Thr Asp Tyr Asn
1 5
<210> 477
<211> 7
<212> PRT
<213> 小鼠
<400> 477
Ile Asp Pro Glu Asn Gly Asp
1 5
<210> 478
<211> 14
<212> PRT
<213> 小鼠
<400> 478
Thr Asn Phe Gly Ser Ser Gln Tyr Tyr Tyr Ala Met Asp Tyr
1 5 10
<210> 479
<211> 9
<212> PRT
<213> 小鼠
<400> 479
Ile Arg Asn Lys Ala Tyr Thr His Ala
1 5
<210> 480
<211> 9
<212> PRT
<213> 小鼠
<400> 480
Thr Arg Pro Asn Trp Asp Val Val Asp
1 5
<210> 481
<211> 9
<212> PRT
<213> 小鼠
<400> 481
Ile Arg Asn Lys Ala Tyr Asn His Ala
1 5
<210> 482
<211> 9
<212> PRT
<213> 小鼠
<400> 482
Thr Arg Pro Asn Trp Asp Val Val Tyr
1 5
<210> 483
<211> 8
<212> PRT
<213> 小鼠
<400> 483
Gly Tyr Thr Phe Thr Thr Phe Gly
1 5
<210> 484
<211> 11
<212> PRT
<213> 小鼠
<400> 484
Ala Arg Asp Asp Asp Tyr Asp Gly Phe Ala Tyr
1 5 10
<210> 485
<211> 7
<212> PRT
<213> 小鼠
<400> 485
Thr Tyr Thr Asp Thr Gly Glu
1 5
<210> 486
<211> 9
<212> PRT
<213> 小鼠
<400> 486
Arg Asp Tyr Gly Gly Tyr Phe Asp Val
1 5
<210> 487
<211> 8
<212> PRT
<213> 小鼠
<400> 487
Gly Tyr Thr Phe Ser Tyr Ser Trp
1 5
<210> 488
<211> 10
<212> PRT
<213> 小鼠
<400> 488
Ala Arg Asn Asp Tyr Asp Glu Gly Glu Tyr
1 5 10
<210> 489
<211> 14
<212> PRT
<213> 小鼠
<400> 489
Thr Asn Ser Gly Ser Ser Gln Tyr Tyr Tyr Ala Met Asp Tyr
1 5 10
<210> 490
<211> 8
<212> PRT
<213> 小鼠
<400> 490
Gly Phe Ser Leu Thr Ser Asn Ala
1 5
<210> 491
<211> 6
<212> PRT
<213> 小鼠
<400> 491
Ile Trp Thr Gly Gly Gly
1 5
<210> 492
<211> 15
<212> PRT
<213> 小鼠
<400> 492
Ala Arg Trp Asp Tyr Tyr Tyr Gly Ser Arg Trp Tyr Phe Asp Val
1 5 10 15
<210> 493
<211> 14
<212> PRT
<213> 小鼠
<400> 493
Thr Thr Tyr Gly Ser Ser Tyr Val Tyr Tyr Ala Met Asp Tyr
1 5 10
<210> 494
<211> 8
<212> PRT
<213> 小鼠
<400> 494
Gly Phe Asn Ile Lys Asp Asp Asn
1 5
<210> 495
<211> 10
<212> PRT
<213> 小鼠
<400> 495
Ile Arg Gly Leu Ser Tyr Ala Met Asp Tyr
1 5 10
<210> 496
<211> 10
<212> PRT
<213> 小鼠
<400> 496
Thr Ser His Leu Ser Gly Ile Phe Asp Tyr
1 5 10
<210> 497
<211> 8
<212> PRT
<213> 小鼠
<400> 497
Val Tyr Thr Phe Thr Glu Tyr Pro
1 5
<210> 498
<211> 7
<212> PRT
<213> 小鼠
<400> 498
Ile His Thr Tyr Ser Gly Glu
1 5
<210> 499
<211> 11
<212> PRT
<213> 小鼠
<400> 499
Ala Arg Trp Arg Phe Tyr Trp Tyr Phe Asp Val
1 5 10
<210> 500
<211> 10
<212> PRT
<213> 小鼠
<400> 500
Gly Phe Ser Leu Ser Thr Ser Gly Met Gly
1 5 10
<210> 501
<211> 6
<212> PRT
<213> 小鼠
<400> 501
Ile Tyr Trp Asp Asp Asp
1 5
<210> 502
<211> 13
<212> PRT
<213> 小鼠
<400> 502
Ala Arg Arg Ala Asn Gly Tyr Tyr Ala Tyr Phe Asp Val
1 5 10
<210> 503
<211> 9
<212> PRT
<213> 小鼠
<400> 503
Ile Arg Asn Lys Ala Lys Asn Gln Ala
1 5
<210> 504
<211> 9
<212> PRT
<213> 小鼠
<400> 504
Thr Ile Trp Gly Tyr Ala Met Asp Tyr
1 5
<210> 505
<211> 8
<212> PRT
<213> 小鼠
<400> 505
Gly Phe Thr Phe Ser Asn Tyr Trp
1 5
<210> 506
<211> 9
<212> PRT
<213> 小鼠
<400> 506
Thr Gly His Pro Gly Ala Met Asp Tyr
1 5
<210> 507
<211> 14
<212> PRT
<213> 小鼠
<400> 507
Thr Asn Tyr Gly Ser Ser Gln Tyr Tyr Tyr Ala Met Asp Tyr
1 5 10
<210> 508
<211> 10
<212> PRT
<213> 小鼠
<400> 508
Thr Ser His Leu Thr Trp Ile Phe Asp Tyr
1 5 10
<210> 509
<211> 8
<212> PRT
<213> 小鼠
<400> 509
Gly Tyr Thr Phe Ser Ser Phe Trp
1 5
<210> 510
<211> 7
<212> PRT
<213> 小鼠
<400> 510
Ala Arg Gly Gly Met Asp Tyr
1 5
<210> 511
<211> 8
<212> PRT
<213> 小鼠
<400> 511
Glu Tyr Thr Leu Thr Glu Tyr Leu
1 5
<210> 512
<211> 7
<212> PRT
<213> 小鼠
<400> 512
Ile Asn Pro Thr Asn Gly Gly
1 5
<210> 513
<211> 8
<212> PRT
<213> 小鼠
<400> 513
Gly Ile Thr Phe Ser Asp Ala Trp
1 5
<210> 514
<211> 8
<212> PRT
<213> 小鼠
<400> 514
Gly Tyr Thr Phe Thr Asp Ser Tyr
1 5
<210> 515
<211> 14
<212> PRT
<213> 小鼠
<400> 515
Thr Thr Trp Gly Tyr Thr Asn Tyr Val Glu Ala Met Asp Tyr
1 5 10
<210> 516
<211> 9
<212> PRT
<213> 小鼠
<400> 516
Ile Arg Asn Lys Ala His Asn His Ala
1 5
<210> 517
<211> 8
<212> PRT
<213> 小鼠
<400> 517
Gly Asp Thr Phe Thr Asp Tyr Tyr
1 5
<210> 518
<211> 14
<212> PRT
<213> 小鼠
<400> 518
Thr Arg Met Asp Tyr Tyr Asp Leu His Trp Tyr Phe Asp Val
1 5 10
<210> 519
<211> 8
<212> PRT
<213> 小鼠
<400> 519
Gly Tyr Thr Phe Thr Asn Tyr Trp
1 5
<210> 520
<211> 7
<212> PRT
<213> 小鼠
<400> 520
Ile Asp Pro Ser Asp Ser Tyr
1 5
<210> 521
<211> 16
<212> PRT
<213> 小鼠
<400> 521
Ala Arg Gly Arg Tyr Tyr Gly Ser Arg Arg Asp Trp Tyr Phe Asp Val
1 5 10 15
<210> 522
<211> 7
<212> PRT
<213> 小鼠
<400> 522
Ile His Pro Asn Ser Gly Ser
1 5
<210> 523
<211> 15
<212> PRT
<213> 小鼠
<400> 523
Ala Arg Arg Gly Tyr Tyr Ser Asn Tyr Gly Asp Ala Met Asp Tyr
1 5 10 15
<210> 524
<211> 13
<212> PRT
<213> 小鼠
<400> 524
Thr Asn Leu Ile Tyr Tyr Tyr Gly Ser Ser Pro Asp Tyr
1 5 10
<210> 525
<211> 8
<212> PRT
<213> 小鼠
<400> 525
Gly Phe Tyr Ile Lys Asp Asp Tyr
1 5
<210> 526
<211> 13
<212> PRT
<213> 小鼠
<400> 526
Thr Thr Leu Ile Tyr Tyr Tyr Gly Ser Asn Ser Asp Tyr
1 5 10
<210> 527
<211> 11
<212> PRT
<213> 小鼠
<400> 527
Ser Arg Asp Asp Asp Tyr Asp Gly Phe Ala Tyr
1 5 10
<210> 528
<211> 8
<212> PRT
<213> 小鼠
<400> 528
Gly Phe Thr Phe Thr Asp Ala Trp
1 5
<210> 529
<211> 8
<212> PRT
<213> 小鼠
<400> 529
Gly Phe Ser Leu Thr Asn Tyr Ala
1 5
<210> 530
<211> 6
<212> PRT
<213> 小鼠
<400> 530
Ile Trp Thr Thr Gly Gly
1 5
<210> 531
<211> 11
<212> PRT
<213> 小鼠
<400> 531
Ala Arg Asn Trp Val Asp Tyr Ala Met Asp Tyr
1 5 10
<210> 532
<211> 10
<212> PRT
<213> 小鼠
<400> 532
Ala Arg Asp Trp Asp Thr Ala Met Asp Tyr
1 5 10
<210> 533
<211> 8
<212> PRT
<213> 小鼠
<400> 533
Gly Phe Ser Leu Ser Ser Tyr Gly
1 5
<210> 534
<211> 6
<212> PRT
<213> 小鼠
<400> 534
Ile Trp Ser Gly Gly Ser
1 5
<210> 535
<211> 11
<212> PRT
<213> 小鼠
<400> 535
Ala Ser Pro Lys Trp Asp Asp Ala Leu Asp Tyr
1 5 10
<210> 536
<211> 13
<212> PRT
<213> 小鼠
<400> 536
Thr Asn Leu Leu Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr
1 5 10
<210> 537
<211> 7
<212> PRT
<213> 小鼠
<400> 537
Ile Asn Pro Ser Thr Gly Thr
1 5
<210> 538
<211> 7
<212> PRT
<213> 小鼠
<400> 538
Ala Arg Gly Ala Gly Ser Tyr
1 5
<210> 539
<211> 15
<212> PRT
<213> 小鼠
<400> 539
Gly Arg Arg Gly Tyr Tyr Ser Asn Tyr Gly Asp Ala Met Asp Tyr
1 5 10 15
<210> 540
<211> 10
<212> PRT
<213> 小鼠
<400> 540
Ile Arg Arg Val Thr Ser Gly Gly Asp Tyr
1 5 10
<210> 541
<211> 8
<212> PRT
<213> 小鼠
<400> 541
Gly Phe Thr Phe Gly Asp Ala Trp
1 5
<210> 542
<211> 10
<212> PRT
<213> 小鼠
<400> 542
Thr Arg Gly Leu Ser Tyr Ala Met Asp Tyr
1 5 10
<210> 543
<211> 14
<212> PRT
<213> 小鼠
<400> 543
Ala Arg Tyr Tyr Tyr Ala Leu Tyr Tyr Ser Ala Met Asp Tyr
1 5 10
<210> 544
<211> 13
<212> PRT
<213> 小鼠
<400> 544
Thr Thr Leu Ile Tyr Tyr Tyr Gly Ser Cys Pro Asp Tyr
1 5 10
<210> 545
<211> 10
<212> PRT
<213> 小鼠
<400> 545
Ala Arg Gly Gly Arg Gly Tyr Phe Asp Val
1 5 10
<210> 546
<211> 8
<212> PRT
<213> 小鼠
<400> 546
Gly Phe Thr Phe Asn Asp Ala Trp
1 5
<210> 547
<211> 10
<212> PRT
<213> 小鼠
<400> 547
Thr Arg Gln Leu Thr Gly Thr Arg Asp Tyr
1 5 10
<210> 548
<211> 8
<212> PRT
<213> 小鼠
<400> 548
Gly Tyr Val Phe Ser Ser Ser Trp
1 5
<210> 549
<211> 10
<212> PRT
<213> 小鼠
<400> 549
Ala Tyr Gly Ser Arg Gly Tyr Phe Asp Val
1 5 10
<210> 550
<211> 8
<212> PRT
<213> 小鼠
<400> 550
Gly Tyr Ala Phe Ser Arg Asp Trp
1 5
<210> 551
<211> 6
<212> PRT
<213> 小鼠
<400> 551
Ala Gln Tyr Phe Asp Tyr
1 5
<210> 552
<211> 10
<212> PRT
<213> 小鼠
<400> 552
Thr Arg Gly Ile Thr Tyr Tyr Phe Asp Tyr
1 5 10
<210> 553
<211> 7
<212> PRT
<213> 小鼠
<400> 553
Ile Tyr Pro Ser Asp Ser Glu
1 5
<210> 554
<211> 7
<212> PRT
<213> 小鼠
<400> 554
Ala Ile Thr Gly Thr Asp Tyr
1 5
<210> 555
<211> 14
<212> PRT
<213> 小鼠
<400> 555
Ala Arg Tyr Tyr Phe Ala Leu Tyr Tyr Ser Ala Met Asp Tyr
1 5 10
<210> 556
<211> 8
<212> PRT
<213> 小鼠
<400> 556
Gly Phe Ser Leu Thr Ser Tyr Ala
1 5
<210> 557
<211> 7
<212> PRT
<213> 小鼠
<400> 557
Ile Asn Pro Lys Asn Gly Gly
1 5
<210> 558
<211> 9
<212> PRT
<213> 小鼠
<400> 558
Thr Lys Gly Leu Ser Phe Met Asp Tyr
1 5
<210> 559
<211> 14
<212> PRT
<213> 小鼠
<400> 559
Thr Arg Met Asp Tyr Tyr Asp Leu Gln Trp Tyr Phe Asp Val
1 5 10
<210> 560
<211> 7
<212> PRT
<213> 小鼠
<400> 560
Ile Glu Pro Asp Asn Gly Asp
1 5
<210> 561
<211> 13
<212> PRT
<213> 小鼠
<400> 561
Thr Thr Leu Ile Tyr Tyr Tyr Gly Ser Ala Ser Asp Tyr
1 5 10
<210> 562
<211> 9
<212> PRT
<213> 小鼠
<400> 562
Ile Arg Asn Lys Gly Lys Asn Tyr Ala
1 5
<210> 563
<211> 8
<212> PRT
<213> 小鼠
<400> 563
Gly Tyr Ala Phe Thr Asn Ser Leu
1 5
<210> 564
<211> 7
<212> PRT
<213> 小鼠
<400> 564
Ile Asn Pro Gly Ser Gly Gly
1 5
<210> 565
<211> 13
<212> PRT
<213> 小鼠
<400> 565
Ala Arg Arg Ile Arg Asp Tyr Gly Thr Ser Val Asp Tyr
1 5 10
<210> 566
<211> 8
<212> PRT
<213> 小鼠
<400> 566
Gly Tyr Ala Phe Ser Arg Tyr Trp
1 5
<210> 567
<211> 6
<212> PRT
<213> 小鼠
<400> 567
Val Gln Tyr Phe Asp Tyr
1 5
<210> 568
<211> 7
<212> PRT
<213> 小鼠
<400> 568
Ile His Pro Asn Ser Gly Asn
1 5
<210> 569
<211> 6
<212> PRT
<213> 小鼠
<400> 569
Ile Ser Tyr Asp Gly Ser
1 5
<210> 570
<211> 9
<212> PRT
<213> 小鼠
<400> 570
Ala Arg Glu Gly Thr Tyr Phe Asp Tyr
1 5
<210> 571
<211> 14
<212> PRT
<213> 小鼠
<400> 571
Thr His Tyr Gly Ser Ser Tyr Ala Phe Tyr Ala Leu Asp Cys
1 5 10
<210> 572
<211> 7
<212> PRT
<213> 小鼠
<400> 572
Ile Tyr Pro Gly Gly Gly Tyr
1 5
<210> 573
<211> 13
<212> PRT
<213> 小鼠
<400> 573
Ala Arg Ser Lys Gly Leu Thr Gly Thr Leu Phe Asp Tyr
1 5 10
<210> 574
<211> 7
<212> PRT
<213> 小鼠
<400> 574
Ile Asn Pro Asn Thr Gly Asp
1 5
<210> 575
<211> 8
<212> PRT
<213> 小鼠
<400> 575
Gly His Thr Phe Thr Asp Tyr Tyr
1 5
<210> 576
<211> 14
<212> PRT
<213> 小鼠
<400> 576
Ala Arg Met Asp Tyr Tyr Asp Leu His Trp Tyr Phe Asp Val
1 5 10
<210> 577
<211> 7
<212> PRT
<213> 小鼠
<400> 577
Ile Asn Pro Asn Asp Gly Gly
1 5
<210> 578
<211> 8
<212> PRT
<213> 小鼠
<400> 578
Gly Tyr Ala Phe Ser Tyr Ser Trp
1 5
<210> 579
<211> 11
<212> PRT
<213> 小鼠
<400> 579
Gly Arg Asp Asp Asp Tyr Asp Gly Phe Ala Tyr
1 5 10
<210> 580
<211> 9
<212> PRT
<213> 小鼠
<400> 580
Val Arg Ser Arg Leu Leu Leu Asp Tyr
1 5
<210> 581
<211> 9
<212> PRT
<213> 小鼠
<400> 581
Thr Arg His Gly Thr Arg Gly Asp Tyr
1 5
<210> 582
<211> 12
<212> PRT
<213> 小鼠
<400> 582
Thr Gly Asp Ser Asn Tyr Arg Tyr Ala Leu Asp Tyr
1 5 10
<210> 583
<211> 7
<212> PRT
<213> 小鼠
<400> 583
Ile Asn Pro Tyr Asn Gly Gly
1 5
<210> 584
<211> 10
<212> PRT
<213> 小鼠
<400> 584
Ala Arg Gly Arg Leu Ala Tyr Phe Asp Tyr
1 5 10
<210> 585
<211> 15
<212> PRT
<213> 小鼠
<400> 585
Ala Arg Arg Leu Tyr Asp Tyr Asp Val Ser Tyr Ala Met Asp Tyr
1 5 10 15
<210> 586
<211> 10
<212> PRT
<213> 小鼠
<400> 586
Thr Arg Asp Trp Asp Asn Ala Met Asp Tyr
1 5 10
<210> 587
<211> 11
<212> PRT
<213> 小鼠
<400> 587
Ala Arg Glu Gly Thr Tyr Gly Tyr Phe Asp Val
1 5 10
<210> 588
<211> 7
<212> PRT
<213> 小鼠
<400> 588
Ile Asp Pro Glu Lys Ala Val
1 5
<210> 589
<211> 13
<212> PRT
<213> 小鼠
<400> 589
Ala Thr Leu Pro Leu Tyr Tyr Asp Tyr Pro Met Asp Tyr
1 5 10
<210> 590
<211> 9
<212> PRT
<213> 小鼠
<400> 590
Ile Arg Asn Lys Ala Asn Asn His Val
1 5
<210> 591
<211> 10
<212> PRT
<213> 小鼠
<400> 591
Thr Arg Gly Leu Ser Tyr Thr Met Asp Ser
1 5 10
<210> 592
<211> 8
<212> PRT
<213> 小鼠
<400> 592
Gly Tyr Thr Phe Thr Asp Tyr Pro
1 5
<210> 593
<211> 7
<212> PRT
<213> 小鼠
<400> 593
Val Arg Ser Gly Phe Asp Tyr
1 5
<210> 594
<211> 7
<212> PRT
<213> 小鼠
<400> 594
Ile Tyr Pro Asn Asn Gly Gly
1 5
<210> 595
<211> 11
<212> PRT
<213> 小鼠
<400> 595
Ala Arg Gly Ala Gly Pro Pro Trp Phe Ala Tyr
1 5 10
<210> 596
<211> 7
<212> PRT
<213> 小鼠
<400> 596
Ala Arg Gly Ala Gly Ala Tyr
1 5
<210> 597
<211> 9
<212> PRT
<213> 小鼠
<400> 597
Gly Phe Ser Ile Asn Ser Asp Cys Tyr
1 5
<210> 598
<211> 6
<212> PRT
<213> 小鼠
<400> 598
Thr Phe Tyr Ser Gly Ile
1 5
<210> 599
<211> 11
<212> PRT
<213> 小鼠
<400> 599
Ala Arg Ile Thr Thr Arg Gly Ala Met Asp Tyr
1 5 10
<210> 600
<211> 10
<212> PRT
<213> 小鼠
<400> 600
Thr Arg Gln Leu Ala Gly Thr Arg Asp Tyr
1 5 10
<210> 601
<211> 7
<212> PRT
<213> 小鼠
<400> 601
Ile Tyr Thr Asp Thr Gly Asp
1 5
<210> 602
<211> 7
<212> PRT
<213> 小鼠
<400> 602
Ile Asn Thr Phe Ser Gly Val
1 5
<210> 603
<211> 10
<212> PRT
<213> 小鼠
<400> 603
Ala Arg Asp Trp Asp His Ala Met Asp Tyr
1 5 10
<210> 604
<211> 11
<212> PRT
<213> 小鼠
<400> 604
Ala Arg Asp Asp Asp Tyr Glu Gly Phe Ala Tyr
1 5 10
<210> 605
<211> 15
<212> PRT
<213> 小鼠
<400> 605
Gly Arg Arg Gly Phe Tyr Ser Asn Tyr Gly Asp Ala Met Asp Tyr
1 5 10 15
<210> 606
<211> 7
<212> PRT
<213> 小鼠
<400> 606
Ile Ala Pro Ser Asp Ser Tyr
1 5
<210> 607
<211> 11
<212> PRT
<213> 小鼠
<400> 607
Ala Arg Asp Gly Ile Gly Trp Pro Leu Gly His
1 5 10
<210> 608
<211> 6
<212> PRT
<213> 小鼠
<400> 608
Gln Asn Val Arg Thr Ala
1 5
<210> 609
<211> 3
<212> PRT
<213> 小鼠
<400> 609
Leu Ala Ser
1
<210> 610
<211> 9
<212> PRT
<213> 小鼠
<400> 610
Leu Gln His Trp Asn Tyr Pro Leu Thr
1 5
<210> 611
<211> 12
<212> PRT
<213> 小鼠
<400> 611
Gln Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr
1 5 10
<210> 612
<211> 3
<212> PRT
<213> 小鼠
<400> 612
Gly Ala Ser
1
<210> 613
<211> 9
<212> PRT
<213> 小鼠
<400> 613
Gln Asn Asp His Ser Tyr Pro Leu Thr
1 5
<210> 614
<211> 7
<212> PRT
<213> 小鼠
<400> 614
Ser Ser Val Ser Ser Ser Tyr
1 5
<210> 615
<211> 3
<212> PRT
<213> 小鼠
<400> 615
Ser Thr Ser
1
<210> 616
<211> 9
<212> PRT
<213> 小鼠
<400> 616
His Gln Phe His Arg Ser Pro Trp Thr
1 5
<210> 617
<211> 9
<212> PRT
<213> 小鼠
<400> 617
His Gln Tyr His Arg Ser Gln Trp Thr
1 5
<210> 618
<211> 9
<212> PRT
<213> 小鼠
<400> 618
His Gln Tyr His Arg Ser Pro Leu Thr
1 5
<210> 619
<211> 11
<212> PRT
<213> 小鼠
<400> 619
Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 620
<211> 3
<212> PRT
<213> 小鼠
<400> 620
Lys Val Ser
1
<210> 621
<211> 9
<212> PRT
<213> 小鼠
<400> 621
Ser Gln Ser Thr His Val Pro Trp Thr
1 5
<210> 622
<211> 5
<212> PRT
<213> 小鼠
<400> 622
Ser Ser Val Ser Tyr
1 5
<210> 623
<211> 3
<212> PRT
<213> 小鼠
<400> 623
Ala Thr Ser
1
<210> 624
<211> 9
<212> PRT
<213> 小鼠
<400> 624
Gln Gln Trp Asn Ser Asn Pro Phe Thr
1 5
<210> 625
<211> 10
<212> PRT
<213> 小鼠
<400> 625
Glu Ser Val Ser Ile Ile Gly Thr Asn Leu
1 5 10
<210> 626
<211> 3
<212> PRT
<213> 小鼠
<400> 626
His Ala Ser
1
<210> 627
<211> 9
<212> PRT
<213> 小鼠
<400> 627
Leu Gln Ser Arg Lys Ile Pro Tyr Thr
1 5
<210> 628
<211> 10
<212> PRT
<213> 小鼠
<400> 628
Gln Ser Val Ser Thr Ser Ser Tyr Ser Phe
1 5 10
<210> 629
<211> 3
<212> PRT
<213> 小鼠
<400> 629
Tyr Ala Ser
1
<210> 630
<211> 9
<212> PRT
<213> 小鼠
<400> 630
Gln His Ser Trp Glu Ile Pro Tyr Thr
1 5
<210> 631
<211> 6
<212> PRT
<213> 小鼠
<400> 631
Glu Asn Ile Tyr Ser Tyr
1 5
<210> 632
<211> 3
<212> PRT
<213> 小鼠
<400> 632
Asn Ala Lys
1
<210> 633
<211> 9
<212> PRT
<213> 小鼠
<400> 633
Gln His His Tyr Gly Thr Pro Tyr Thr
1 5
<210> 634
<211> 10
<212> PRT
<213> 小鼠
<400> 634
Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr
1 5 10
<210> 635
<211> 10
<212> PRT
<213> 小鼠
<400> 635
Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu
1 5 10
<210> 636
<211> 3
<212> PRT
<213> 小鼠
<400> 636
Ala Ala Ser
1
<210> 637
<211> 9
<212> PRT
<213> 小鼠
<400> 637
Gln Gln Thr Arg Lys Val Pro Trp Thr
1 5
<210> 638
<211> 12
<212> PRT
<213> 小鼠
<400> 638
Gln Ser Leu Leu Asn Ser Gly His Gln Lys Asn Tyr
1 5 10
<210> 639
<211> 9
<212> PRT
<213> 小鼠
<400> 639
Gln Asn Asp His Arg Tyr Pro Leu Thr
1 5
<210> 640
<211> 6
<212> PRT
<213> 小鼠
<400> 640
Gln Asp Ile Asn Ser Tyr
1 5
<210> 641
<211> 3
<212> PRT
<213> 小鼠
<400> 641
Arg Ala Asn
1
<210> 642
<211> 9
<212> PRT
<213> 小鼠
<400> 642
Leu Gln Tyr Asp Glu Phe Pro Phe Thr
1 5
<210> 643
<211> 6
<212> PRT
<213> 小鼠
<400> 643
Gln Asp Ile Asn Lys Tyr
1 5
<210> 644
<211> 3
<212> PRT
<213> 小鼠
<400> 644
Tyr Thr Ser
1
<210> 645
<211> 9
<212> PRT
<213> 小鼠
<400> 645
Leu Gln Tyr Asp Asn Leu Pro Arg Thr
1 5
<210> 646
<211> 9
<212> PRT
<213> 小鼠
<400> 646
Leu Gln His Trp Ile Tyr Pro Leu Thr
1 5
<210> 647
<211> 10
<212> PRT
<213> 小鼠
<400> 647
Glu Ser Phe Glu Tyr Tyr Gly Thr Ser Phe
1 5 10
<210> 648
<211> 9
<212> PRT
<213> 小鼠
<400> 648
Gln Gln Ser Arg Lys Val Pro Tyr Thr
1 5
<210> 649
<211> 6
<212> PRT
<213> 小鼠
<400> 649
Gln Asn Val Gly Thr Asn
1 5
<210> 650
<211> 3
<212> PRT
<213> 小鼠
<400> 650
Ser Ala Ser
1
<210> 651
<211> 9
<212> PRT
<213> 小鼠
<400> 651
Gln Gln Tyr Gly Thr Tyr Pro Tyr Thr
1 5
<210> 652
<211> 9
<212> PRT
<213> 小鼠
<400> 652
Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr
1 5
<210> 653
<211> 9
<212> PRT
<213> 小鼠
<400> 653
Leu Gln Ser Arg Lys Ile Pro Cys Thr
1 5
<210> 654
<211> 3
<212> PRT
<213> 小鼠
<400> 654
His Thr Ser
1
<210> 655
<211> 9
<212> PRT
<213> 小鼠
<400> 655
Leu Gln Ser Arg Lys Ile Pro Trp Thr
1 5
<210> 656
<211> 5
<212> PRT
<213> 小鼠
<400> 656
Ser Ser Ile Ser Tyr
1 5
<210> 657
<211> 3
<212> PRT
<213> 小鼠
<400> 657
Asp Thr Ser
1
<210> 658
<211> 9
<212> PRT
<213> 小鼠
<400> 658
His Gln Arg Asn Tyr Tyr Pro Trp Thr
1 5
<210> 659
<211> 6
<212> PRT
<213> 小鼠
<400> 659
Gln Asp Val Gly Thr Ala
1 5
<210> 660
<211> 3
<212> PRT
<213> 小鼠
<400> 660
Trp Ala Ser
1
<210> 661
<211> 9
<212> PRT
<213> 小鼠
<400> 661
Gln Gln Tyr Ser Thr Ser Pro Tyr Thr
1 5
<210> 662
<211> 6
<212> PRT
<213> 小鼠
<400> 662
Gln Ser Ile Ser Asn Tyr
1 5
<210> 663
<211> 9
<212> PRT
<213> 小鼠
<400> 663
Gln Gln Ser Tyr Ile Trp Pro Leu Thr
1 5
<210> 664
<211> 11
<212> PRT
<213> 小鼠
<400> 664
Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr
1 5 10
<210> 665
<211> 3
<212> PRT
<213> 小鼠
<400> 665
Leu Val Ser
1
<210> 666
<211> 9
<212> PRT
<213> 小鼠
<400> 666
Trp Gln Gly Thr His Phe Pro Arg Thr
1 5
<210> 667
<211> 10
<212> PRT
<213> 小鼠
<400> 667
Glu Ser Val Glu Tyr Tyr Gly Thr Gly Phe
1 5 10
<210> 668
<211> 3
<212> PRT
<213> 小鼠
<400> 668
Ala Ala Ala
1
<210> 669
<211> 9
<212> PRT
<213> 小鼠
<400> 669
Gln Gln Trp Ser Ser His Pro Leu Thr
1 5
<210> 670
<211> 10
<212> PRT
<213> 小鼠
<400> 670
Gln Ser Val Ser Thr Ser Ser Tyr Gly Phe
1 5 10
<210> 671
<211> 6
<212> PRT
<213> 小鼠
<400> 671
Gln Glu Ile Ser Gly Tyr
1 5
<210> 672
<211> 9
<212> PRT
<213> 小鼠
<400> 672
Leu Gln Tyr Ala Ser Tyr Pro Trp Thr
1 5
<210> 673
<211> 9
<212> PRT
<213> 小鼠
<400> 673
Gln Gln Tyr Asn Ser Tyr Pro Trp Thr
1 5
<210> 674
<211> 6
<212> PRT
<213> 小鼠
<400> 674
Glu Asp Ile Tyr Asn Arg
1 5
<210> 675
<211> 3
<212> PRT
<213> 小鼠
<400> 675
Gly Ala Thr
1
<210> 676
<211> 9
<212> PRT
<213> 小鼠
<400> 676
Gln Gln Tyr Trp Asn Ile Pro Phe Thr
1 5
<210> 677
<211> 10
<212> PRT
<213> 小鼠
<400> 677
Glu Ser Val Ser Ile Ile Gly Ala Asn Leu
1 5 10
<210> 678
<211> 7
<212> PRT
<213> 小鼠
<400> 678
Ser Ser Val Tyr Ser Ser Tyr
1 5
<210> 679
<211> 6
<212> PRT
<213> 小鼠
<400> 679
Gln Ser Val Ser His Asp
1 5
<210> 680
<211> 9
<212> PRT
<213> 小鼠
<400> 680
Gln Gln Asp Tyr Ser Ser Pro Phe Thr
1 5
<210> 681
<211> 10
<212> PRT
<213> 小鼠
<400> 681
Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr
1 5 10
<210> 682
<211> 9
<212> PRT
<213> 小鼠
<400> 682
Gln Gln Thr Asn Glu Asp Pro Phe Thr
1 5
<210> 683
<211> 6
<212> PRT
<213> 小鼠
<400> 683
Glu Asn Val Arg Thr Ala
1 5
<210> 684
<211> 9
<212> PRT
<213> 小鼠
<400> 684
Leu Gln Tyr Trp Ile Tyr Pro Leu Thr
1 5
<210> 685
<211> 10
<212> PRT
<213> 小鼠
<400> 685
Gln Ser Val Ser Thr Ser Gly Tyr Ser Phe
1 5 10
<210> 686
<211> 5
<212> PRT
<213> 小鼠
<400> 686
Ser Ser Val Thr Tyr
1 5
<210> 687
<211> 9
<212> PRT
<213> 小鼠
<400> 687
Gln Gln Trp Asn Ser Tyr Pro Leu Thr
1 5
<210> 688
<211> 9
<212> PRT
<213> 小鼠
<400> 688
Gln His Ser Trp Glu Ile Pro Arg Thr
1 5
<210> 689
<211> 5
<212> PRT
<213> 小鼠
<400> 689
Leu Ser Val Ser Tyr
1 5
<210> 690
<211> 9
<212> PRT
<213> 小鼠
<400> 690
Gln Gln Trp Ser Ser Ile Pro Phe Thr
1 5
<210> 691
<211> 6
<212> PRT
<213> 小鼠
<400> 691
Gln Asp Ile Asn Asn Tyr
1 5
<210> 692
<211> 8
<212> PRT
<213> 小鼠
<400> 692
Leu Gln Tyr Asp Glu Phe Arg Thr
1 5
<210> 693
<211> 5
<212> PRT
<213> 小鼠
<400> 693
Ser Gly Val Asn Tyr
1 5
<210> 694
<211> 3
<212> PRT
<213> 小鼠
<400> 694
Asp Thr Phe
1
<210> 695
<211> 9
<212> PRT
<213> 小鼠
<400> 695
Gln Gln Trp Ser Thr Tyr Pro Tyr Thr
1 5
<210> 696
<211> 9
<212> PRT
<213> 小鼠
<400> 696
Leu Gln Ser Arg Lys Ile Pro Tyr Ala
1 5
<210> 697
<211> 5
<212> PRT
<213> 小鼠
<400> 697
Ser Asp Ile Asn Tyr
1 5
<210> 698
<211> 9
<212> PRT
<213> 小鼠
<400> 698
Gln Gln Tyr Trp Asn Thr Pro Phe Thr
1 5
<210> 699
<211> 6
<212> PRT
<213> 小鼠
<400> 699
Gln Asp Ile Ser Asn Tyr
1 5
<210> 700
<211> 9
<212> PRT
<213> 小鼠
<400> 700
Gln Gln Gly Asn Thr Leu Pro Tyr Thr
1 5
<210> 701
<211> 10
<212> PRT
<213> 小鼠
<400> 701
Gln Gln Tyr Asn Ser Tyr Pro Leu Leu Thr
1 5 10
<210> 702
<211> 12
<212> PRT
<213> 小鼠
<400> 702
Gln Ser Leu Phe Asn Ser Gly His Gln Lys Asn Tyr
1 5 10
<210> 703
<211> 6
<212> PRT
<213> 小鼠
<400> 703
Gln Asn Val Gly Thr Ala
1 5
<210> 704
<211> 9
<212> PRT
<213> 小鼠
<400> 704
Gln Gln Tyr Ser Ser Phe Pro Phe Thr
1 5
<210> 705
<211> 12
<212> PRT
<213> 小鼠
<400> 705
Gln Ser Leu Leu Asn Ser Gly Tyr Gln Lys Asn Tyr
1 5 10
<210> 706
<211> 11
<212> PRT
<213> 小鼠
<400> 706
Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 707
<211> 3
<212> PRT
<213> 小鼠
<400> 707
Ile Val Ser
1
<210> 708
<211> 9
<212> PRT
<213> 小鼠
<400> 708
Ser Gln Ser Thr His Leu Pro Trp Thr
1 5
<210> 709
<211> 6
<212> PRT
<213> 小鼠
<400> 709
Gln Asp Ile Asn Ser Phe
1 5
<210> 710
<211> 9
<212> PRT
<213> 小鼠
<400> 710
Gln Gln Gly Asn Thr Leu Pro Pro Thr
1 5
<210> 711
<211> 9
<212> PRT
<213> 小鼠
<400> 711
Gln Gln Gly Asn Thr Leu Pro Trp Thr
1 5
<210> 712
<211> 6
<212> PRT
<213> 小鼠
<400> 712
Gln Asp Ile Ile Ser Tyr
1 5
<210> 713
<211> 3
<212> PRT
<213> 小鼠
<400> 713
Ile Leu Ser
1
<210> 714
<211> 11
<212> PRT
<213> 小鼠
<400> 714
Gln Ser Leu Val Phe Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 715
<211> 9
<212> PRT
<213> 小鼠
<400> 715
Gln His Ser Trp Glu Ile Pro Pro Thr
1 5
<210> 716
<211> 6
<212> PRT
<213> 小鼠
<400> 716
Gln Asn Val His Thr Ala
1 5
<210> 717
<211> 9
<212> PRT
<213> 小鼠
<400> 717
Ser Gln Ser Thr His Val Pro Tyr Thr
1 5
<210> 718
<211> 9
<212> PRT
<213> 小鼠
<400> 718
Gln Gln Tyr Ser Ser Tyr Pro Leu Thr
1 5
<210> 719
<211> 9
<212> PRT
<213> 小鼠
<400> 719
Gln His Ser Trp Glu Leu Pro Pro Thr
1 5
<210> 720
<211> 9
<212> PRT
<213> 小鼠
<400> 720
Leu Gln Ser Lys Lys Ile Pro Tyr Thr
1 5
<210> 721
<211> 12
<212> PRT
<213> 小鼠
<400> 721
Gln Ser Leu Leu Asn Ser Gly Asp Gln Met His Tyr
1 5 10
<210> 722
<211> 6
<212> PRT
<213> 小鼠
<400> 722
Gln Asp Ile Tyr Asn Tyr
1 5
<210> 723
<211> 9
<212> PRT
<213> 小鼠
<400> 723
Leu Gln Tyr Asp Glu Phe Pro Arg Thr
1 5
<210> 724
<211> 11
<212> PRT
<213> 小鼠
<400> 724
Gln Ser Leu Val His Ser Tyr Gly Asn Thr Tyr
1 5 10
<210> 725
<211> 9
<212> PRT
<213> 小鼠
<400> 725
Gln Gln Trp Ser Ser Asn Leu Tyr Thr
1 5
<210> 726
<211> 3
<212> PRT
<213> 小鼠
<400> 726
Arg Thr Ser
1
<210> 727
<211> 9
<212> PRT
<213> 小鼠
<400> 727
Gln Gln Tyr His Ser Tyr Pro Tyr Thr
1 5
<210> 728
<211> 8
<212> PRT
<213> 小鼠
<400> 728
Leu Gln Tyr Asp Asn Leu Tyr Thr
1 5
<210> 729
<211> 10
<212> PRT
<213> 小鼠
<400> 729
Ser Gln Ser Thr His Val Pro Pro Tyr Thr
1 5 10
<210> 730
<211> 6
<212> PRT
<213> 小鼠
<400> 730
Gln Asp Ile Asn Asn Phe
1 5
<210> 731
<211> 9
<212> PRT
<213> 小鼠
<400> 731
Leu Gln Tyr Asp Asp Leu Pro Arg Thr
1 5
<210> 732
<211> 10
<212> PRT
<213> 小鼠
<400> 732
Gln Gln Tyr Asn Thr Tyr Pro Leu Leu Thr
1 5 10
<210> 733
<211> 12
<212> PRT
<213> 小鼠
<400> 733
Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr
1 5 10
<210> 734
<211> 9
<212> PRT
<213> 小鼠
<400> 734
His Gln Trp Ser Ser Tyr Pro Phe Thr
1 5
<210> 735
<211> 9
<212> PRT
<213> 小鼠
<400> 735
Gln Gln Tyr Gln Asn Thr Pro Phe Thr
1 5
<210> 736
<211> 3
<212> PRT
<213> 小鼠
<400> 736
Arg Ala Ser
1
<210> 737
<211> 9
<212> PRT
<213> 小鼠
<400> 737
Leu Gln Tyr Asp Glu Phe Pro Tyr Thr
1 5
<210> 738
<211> 9
<212> PRT
<213> 小鼠
<400> 738
Leu Gln His Trp Ser Tyr Pro Leu Thr
1 5
<210> 739
<211> 11
<212> PRT
<213> 小鼠
<400> 739
Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 740
<211> 9
<212> PRT
<213> 小鼠
<400> 740
Phe Gln Val Ser His Val Pro Trp Thr
1 5
<210> 741
<211> 8
<212> PRT
<213> 小鼠
<400> 741
Leu Gln Tyr Asp Asn Leu Arg Thr
1 5
<210> 742
<211> 9
<212> PRT
<213> 小鼠
<400> 742
Gln Gln Trp Asn Ser Tyr Pro Pro Thr
1 5
<210> 743
<211> 9
<212> PRT
<213> 小鼠
<400> 743
Gln Gln Trp Ser Ser Tyr Pro Pro Thr
1 5
<210> 744
<211> 3
<212> PRT
<213> 小鼠
<400> 744
Leu Thr Ser
1
<210> 745
<211> 9
<212> PRT
<213> 小鼠
<400> 745
Gln Gln Trp Ser Ser Tyr Pro Phe Thr
1 5
<210> 746
<211> 6
<212> PRT
<213> 小鼠
<400> 746
Gln Asn Val Arg Ser Ala
1 5
<210> 747
<211> 9
<212> PRT
<213> 小鼠
<400> 747
Gln Gln Tyr Ser Ser Tyr Pro Trp Thr
1 5
<210> 748
<211> 6
<212> PRT
<213> 小鼠
<400> 748
Asp His Ile Asn Asn Trp
1 5
<210> 749
<211> 9
<212> PRT
<213> 小鼠
<400> 749
Gln Gln Tyr Trp Ser Ile Pro Leu Thr
1 5
<210> 750
<211> 9
<212> PRT
<213> 小鼠
<400> 750
Gln Gln Tyr Ser Ala Ser Pro Tyr Thr
1 5
<210> 751
<211> 12
<212> PRT
<213> 小鼠
<400> 751
Gln Ser Leu Leu Asn Ser Gly Tyr Gln Lys Ile Tyr
1 5 10
<210> 752
<211> 9
<212> PRT
<213> 小鼠
<400> 752
Gln Asn Asp His Thr Tyr Pro Leu Thr
1 5
<210> 753
<211> 5
<212> PRT
<213> 小鼠
<400> 753
Ser Ser Met Ser Tyr
1 5
<210> 754
<211> 9
<212> PRT
<213> 小鼠
<400> 754
His Gln Arg Ser Ser Tyr Pro Trp Thr
1 5
<210> 755
<211> 9
<212> PRT
<213> 小鼠
<400> 755
Gln Gln Trp Ser Ser Asn Pro Leu Thr
1 5
<210> 756
<211> 9
<212> PRT
<213> 小鼠
<400> 756
Leu Gln Cys Ala Asn Tyr Pro Leu Thr
1 5
<210> 757
<211> 9
<212> PRT
<213> 小鼠
<400> 757
Gln Gln Trp Ser Ser Tyr Pro Tyr Thr
1 5
<210> 758
<211> 3
<212> PRT
<213> 小鼠
<400> 758
Tyr Ile Ser
1
<210> 759
<211> 6
<212> PRT
<213> 小鼠
<400> 759
Gln Asp Ile Ser Asn Phe
1 5
<210> 760
<211> 9
<212> PRT
<213> 小鼠
<400> 760
Gln Gln Gly Asp Thr Leu Pro Tyr Thr
1 5
<210> 761
<211> 11
<212> PRT
<213> 小鼠
<400> 761
Gln Ser Leu Val His Ser Tyr Gly Asp Thr Tyr
1 5 10
<210> 762
<211> 5
<212> PRT
<213> 小鼠
<400> 762
Ser Ser Val Asn Tyr
1 5
<210> 763
<211> 10
<212> PRT
<213> 小鼠
<400> 763
Gln Gln Phe Asn Ser Tyr Pro Leu Leu Thr
1 5 10
<210> 764
<211> 9
<212> PRT
<213> 小鼠
<400> 764
Gln Gln Val Asn Thr Leu Pro Tyr Thr
1 5
<210> 765
<211> 11
<212> PRT
<213> 小鼠
<400> 765
Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 766
<211> 9
<212> PRT
<213> 小鼠
<400> 766
Leu Gln Tyr Trp Asn Tyr Pro Leu Thr
1 5
<210> 767
<211> 9
<212> PRT
<213> 小鼠
<400> 767
Ser Gln Gly Thr His Ile Pro Trp Thr
1 5
<210> 768
<211> 9
<212> PRT
<213> 小鼠
<400> 768
Ser His Ser Thr Leu Val Pro Trp Thr
1 5
<210> 769
<211> 6
<212> PRT
<213> 小鼠
<400> 769
Gln Ser Val Ser Tyr Asp
1 5
<210> 770
<211> 3
<212> PRT
<213> 小鼠
<400> 770
Tyr Ala Phe
1
<210> 771
<211> 9
<212> PRT
<213> 小鼠
<400> 771
Gln Gln Asp Tyr Asn Ser Pro Tyr Thr
1 5
<210> 772
<211> 9
<212> PRT
<213> 小鼠
<400> 772
Gln Gln Trp Asn Thr Tyr Pro Pro Thr
1 5
<210> 773
<211> 9
<212> PRT
<213> 小鼠
<400> 773
His Gln Phe His His Ser Gln Trp Thr
1 5
<210> 774
<211> 6
<212> PRT
<213> 小鼠
<400> 774
Gln Ile Val Arg Thr Ala
1 5
<210> 775
<211> 9
<212> PRT
<213> 小鼠
<400> 775
Gln Gln Gly Asn Thr Leu Pro Leu Thr
1 5
<210> 776
<211> 9
<212> PRT
<213> 小鼠
<400> 776
Gln Gln Tyr Trp Ser Thr Pro Leu Thr
1 5
<210> 777
<211> 10
<212> PRT
<213> 小鼠
<400> 777
Glu Asn Leu Glu Tyr Tyr Gly Thr Ser Leu
1 5 10
<210> 778
<211> 6
<212> PRT
<213> 小鼠
<400> 778
Gln Asn Val Arg Thr Thr
1 5
<210> 779
<211> 12
<212> PRT
<213> 小鼠
<400> 779
Gln Ser Leu Leu Asn Ser Gly Asn Gln Glu Thr Tyr
1 5 10
<210> 780
<211> 6
<212> PRT
<213> 小鼠
<400> 780
Glu Asp Ile Phe Asn Arg
1 5
<210> 781
<211> 9
<212> PRT
<213> 小鼠
<400> 781
Gln Gln Tyr Trp Thr Ile Pro Phe Thr
1 5
<210> 782
<211> 9
<212> PRT
<213> 小鼠
<400> 782
Gln Gln Tyr Trp Ser Thr Pro Arg Thr
1 5
<210> 783
<211> 9
<212> PRT
<213> 小鼠
<400> 783
Gln Gln Tyr His Asn Tyr Pro Tyr Thr
1 5
<210> 784
<211> 9
<212> PRT
<213> 小鼠
<400> 784
Ser Gln Ser Thr His Val Pro Leu Thr
1 5
Claims (19)
1.一种结合SARS-CoV-2S蛋白(SEQ ID NO:1)的抗体或其抗原结合片段,其特征在于包含下列组合之一:
a)氨基酸序列为SEQ ID NO:382的HCDR1,氨基酸序列为SEQ ID NO:383的HCDR2,氨基酸序列为SEQ ID NO:446的HCDR3,氨基酸序列为SEQ ID NO:608的LCDR1,氨基酸序列为SEQID NO:609的LCDR2,和氨基酸序列为SEQ ID NO:610的LCDR3;
b)氨基酸序列为SEQ ID NO:519的HCDR1,氨基酸序列为SEQ ID NO:522的HCDR2,氨基酸序列为SEQ ID NO:523的HCDR3,氨基酸序列为SEQ ID NO:622的LCDR1,氨基酸序列为SEQID NO:726的LCDR2,和氨基酸序列为SEQ ID NO:727的LCDR3;
c)氨基酸序列为SEQ ID NO:391的HCDR1,氨基酸序列为SEQ ID NO:386的HCDR2,氨基酸序列为SEQ ID NO:581的HCDR3,氨基酸序列为SEQ ID NO:608的LCDR1,氨基酸序列为SEQID NO:609的LCDR2,和氨基酸序列为SEQ ID NO:766的LCDR3。
2.根据权利要求1所述的抗体或其抗原结合片段,其中所述HCDR1的氨基酸序列为SEQID NO:382,所述HCDR2的氨基酸序列为SEQ ID NO:383,所述HCDR3的氨基酸序列为SEQ IDNO:446,所述LCDR1的氨基酸序列为SEQ ID NO:608,所述LCDR2的氨基酸序列为SEQ ID NO:609,及所述LCDR3的氨基酸序列为SEQ ID NO:610。
3.根据权利要求1所述的抗体或其抗原结合片段,其中所述HCDR1的氨基酸序列为SEQID NO:519,所述HCDR2的氨基酸序列为SEQ ID NO:522,所述HCDR3的氨基酸序列为SEQ IDNO:523,所述LCDR1的氨基酸序列为SEQ ID NO:622,所述LCDR2的氨基酸序列为SEQ ID NO:726,及所述LCDR3的氨基酸序列为SEQ ID NO:727。
4.根据权利要求1所述的抗体或其抗原结合片段,其中所述HCDR1的氨基酸序列为SEQID NO:391,所述HCDR2的氨基酸序列为SEQ ID NO:386,所述HCDR3的氨基酸序列为SEQ IDNO:581,所述LCDR1的氨基酸序列为SEQ ID NO:608,所述LCDR2的氨基酸序列为SEQ ID NO:609,及所述LCDR3的氨基酸序列为SEQ ID NO:766。
5.一种结合SARS-CoV-2S蛋白(SEQ ID NO:1)的抗体或其抗原结合片段,其特征在于包含下述组合之一:
a)一个VH,其氨基酸序列为SEQ ID NO:31,及一个VL,其氨基酸序列为SEQ ID NO:297;
b)一个VH,其氨基酸序列为SEQ ID NO:161,及一个VL,其氨基酸序列为SEQ ID NO:366;
c)一个VH,其氨基酸序列为SEQ ID NO:100,及一个VL,其氨基酸序列为SEQ ID NO:301。
6.根据权利要求5所述的抗体或其抗原结合片段,其中所述VH的氨基酸序列为SEQ IDNO:31,及所述VL的氨基酸序列为SEQ ID NO:297。
7.根据权利要求5所述的抗体或其抗原结合片段,其中所述VH的氨基酸序列为SEQ IDNO:161,及所述VL的氨基酸序列为SEQ ID NO:366。
8.根据权利要求5所述的抗体或其抗原结合片段,其中所述VH的氨基酸序列为SEQ IDNO:100,及所述VL的氨基酸序列为SEQ ID NO:301。
9.一种结合SARS-CoV-2S蛋白(SEQ ID NO:1)的抗体或其抗原结合片段,其特征在于包含下述组合之一:
a)一条重链,其包含氨基酸序列SEQ ID NO:31,以及一条轻链,其包含氨基酸序列SEQID NO:297;
b)一条重链,其包含氨基酸序列SEQ ID NO:161,以及一条轻链,其包含氨基酸序列SEQID NO:366;
c)一条重链,其包含氨基酸序列SEQ ID NO:100,以及一条轻链,其包含氨基酸序列SEQID NO:301。
10.根据权利要求9所述的抗体或其抗原结合片段,其中所述重链包含氨基酸序列SEQID NO:31,及所述轻链包含氨基酸序列SEQ ID NO:297。
11.根据权利要求9所述的抗体或其抗原结合片段,其中所述重链包含氨基酸序列SEQID NO:161,及所述轻链包含氨基酸序列SEQ ID NO:366。
12.根据权利要求9所述的抗体或其抗原结合片段,其中所述重链包含氨基酸序列SEQID NO:100,及所述轻链包含氨基酸序列SEQ ID NO:301。
13.一种药物组合物,其包含权利要求1-12中任一项的抗体或其抗原结合片段。
14.一种试剂盒,其包含权利要求1-13中任一项的抗体或其抗原结合片段。
15.一种预防或治疗暴露于SARS-CoV-2的受试者感染SARS-CoV-2的方法,包括施用权利要求13所述的药物组合物。
16.根据权利要求15所述的方法,其中,所述药物组合物经由皮下、静脉内、肠胃外或肌肉内途径施用。
17.根据权利要求16所述的方法,其中,所述药物组合物通过皮下注射或静脉输注施用。
18.一种减少、延缓或以其它方式抑制已确诊COVID-19个体中SARS-CoV-2的生长和/或复制的方法,包括施用权利要求13所述的药物组合物。
19.一种治疗SARS-CoV-2感染的方法,包括为有此需求的受试者施用能够与SARS-CoV-2S蛋白相结合的抗体或其抗原结合片段,其量为治疗COVID-19的有效量,其中所述抗体或其抗原结合片段包含下述组合之一:
a)一个重链可变区(VH),其包含氨基酸序列为SEQ ID NO:382的HCDR1、氨基酸序列为SEQ ID NO:383的HCDR2、以及氨基酸序列为SEQ ID NO:446的HCDR3;和一个轻链可变区(VL),其包含氨基酸序列为SEQ ID NO:608的LCDR1、氨基酸序列为SEQ ID NO:609的LCDR2、以及氨基酸序列为SEQ ID NO:610的LCDR3;
b)一个重链可变区(VH),其包含氨基酸序列为SEQ ID NO:519的HCDR1、氨基酸序列为SEQ ID NO:522的HCDR2、以及氨基酸序列为SEQ ID NO:523的HCDR3;和一个轻链可变区(VL),其包含氨基酸序列为SEQ ID NO:622的LCDR1、氨基酸序列为SEQ ID NO:726的LCDR2、以及氨基酸序列为SEQ ID NO:727的LCDR3;
c)一个重链可变区(VH),其包含氨基酸序列为SEQ ID NO:391的HCDR1、氨基酸序列为SEQ ID NO:386的HCDR2、以及氨基酸序列为SEQ ID NO:581的HCDR3;和一个轻链可变区(VL),其包含氨基酸序列为SEQ ID NO:608的LCDR1、氨基酸序列为SEQ ID NO:609的LCDR2、以及氨基酸序列为SEQ ID NO:766的LCDR3。
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