CN115900245A - Chemical bulk drug drying method and drying equipment with nitrogen protection - Google Patents

Chemical bulk drug drying method and drying equipment with nitrogen protection Download PDF

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Publication number
CN115900245A
CN115900245A CN202211421947.0A CN202211421947A CN115900245A CN 115900245 A CN115900245 A CN 115900245A CN 202211421947 A CN202211421947 A CN 202211421947A CN 115900245 A CN115900245 A CN 115900245A
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drying
nitrogen
drying device
bulk drug
chemical
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CN202211421947.0A
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王荣
高山
潘俊
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LINGNAN PHARMACEUTICAL Ltd
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LINGNAN PHARMACEUTICAL Ltd
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/10Process efficiency

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Abstract

The invention relates to the technical field of chemical raw material medicines, in particular to a drying method and drying equipment of a chemical raw material medicine with nitrogen protection. According to the chemical bulk drug drying method and the drying equipment with the nitrogen protection function, internal oxygen can be discharged to the maximum degree, internal gas is dried, and the maximum efficacy of the internal chemical bulk drug is guaranteed.

Description

Chemical bulk drug drying method and drying equipment with nitrogen protection
[ technical field ] A method for producing a semiconductor device
The invention relates to the technical field of chemical raw material medicines, in particular to a drying method and drying equipment for a chemical raw material medicine with nitrogen protection.
[ background of the invention ]
The conventional drying methods of the chemical raw material medicines comprise blast drying and vacuum drying, but some chemical raw material medicines are easy to react with oxygen in the air, so that the degradation is caused, the product quality is reduced, and even diseases cannot be treated. For chemical raw material medicines with the properties, vacuum drying is generally adopted, namely, a vacuum pump is adopted to carry out vacuumizing operation firstly, and then a drying box is opened to carry out drying treatment, but absolute vacuum is difficult to realize in reality, partial oxygen still exists inevitably, the vacuum pump is required to be continuously adopted to carry out vacuumizing operation on the drying box, and the energy consumption is increased during the operation of the vacuum pump.
[ summary of the invention ]
The invention aims to provide a drying method and drying equipment for chemical bulk drugs with nitrogen protection, which can discharge oxygen in the chemical bulk drugs to the greatest extent, ensure the drying of internal gas and ensure the maximum efficacy of the chemical bulk drugs in the chemical bulk drugs.
The application is realized by the following technical scheme: a drying method of chemical bulk drugs with nitrogen protection comprises the following steps:
step S1: respectively assembling a vacuumizing device, a nitrogen conveying device, an oxygen concentration detector, an alarm device and a timing device with a drying device to build chemical raw material drying equipment;
step S2: placing the chemical bulk drug in a drying device, vacuumizing the drying device by a vacuumizing device, and closing the vacuumizing device and starting a nitrogen conveying device after the vacuum degree in the drying device reaches a set vacuum degree;
and step S3: and after the drying device is filled with nitrogen, repeating the operation of the step S2 for N times, starting the drying device to perform heating drying, simultaneously reducing the flow rate of the nitrogen conveying device to a set flow rate, closing the drying device after the timing device reaches the set time, and maintaining the set flow rate by the nitrogen conveying device so as to continuously introduce the nitrogen into the drying device.
In the method for drying the chemical bulk drug with nitrogen protection, when the oxygen concentration detector detects that the oxygen concentration in the drying device reaches the set concentration in step S3, the alarm device is triggered to alarm, and the nitrogen delivery device is regulated and controlled to increase the nitrogen delivery flow.
According to the method for drying the chemical bulk drug with the nitrogen protection function, the set concentration is 3-10%.
In the method for drying the chemical raw material drug with the nitrogen protection, the set flow rate in the step S3 is 0.05-0.2L/min.
In the method for drying the chemical bulk drug with the nitrogen protection, the number N of times in the step S3 is 1-3.
The utility model provides a chemical raw material medicine drying equipment with nitrogen protection, includes drying device, and intercommunication drying device's evacuating device and nitrogen gas conveyor, be equipped with the holding chamber that is used for placing chemical raw material medicine in the drying device, evacuating device includes evacuation pump, intercommunication evacuation pump with the pipeline in holding chamber and install in first valve on the pipeline, the last second valve that is provided with of nitrogen gas conveyor, the last observation port that still is equipped with of drying device.
The chemical bulk drug drying equipment with nitrogen protection comprises a nitrogen storage tank, a communicating valve arranged on the nitrogen storage tank, and a conveying pipe for communicating the communicating valve with the accommodating cavity, wherein the second valve is arranged on the conveying pipe, and the nitrogen conveying device further comprises a flow meter arranged on one side of an air outlet end of the second valve and electrically connected with the communicating valve so as to detect the flow rate of nitrogen in the conveying pipe.
The chemical bulk drug drying device with the nitrogen protection function further comprises a vacuum degree meter which is arranged on the drying device and communicated with the accommodating cavity, wherein the vacuum degree meter is electrically connected with the vacuum pumping pump so as to detect the vacuum degree in the accommodating cavity and control the vacuum pumping pump to be turned on/off.
According to the chemical bulk drug drying equipment with nitrogen protection, the drying device is further provided with the alarm device and the timing device, the timing device is respectively electrically connected with the drying device and the alarm device, and the timing device closes the drying device when timing is finished and triggers the alarm device to give an alarm.
The chemical bulk drug drying device with nitrogen protection further comprises an oxygen concentration detector arranged in the accommodating cavity, the oxygen concentration detector is electrically connected with the alarm device and the flowmeter respectively, the oxygen concentration detector detects the oxygen concentration in the accommodating cavity and transmits detection signals to the alarm device and the flowmeter so as to trigger the alarm device to alarm, and the nitrogen conveying device increases/maintains the conveying flow of nitrogen.
Compared with the prior art, the method has the following advantages:
according to the chemical bulk drug drying method and drying equipment with nitrogen protection, the vacuumizing device is used for vacuumizing, the nitrogen conveying device is used for introducing nitrogen into the drying device after vacuumizing operation is carried out, the drying device is started for drying after the operation is repeated twice, internal oxygen can be discharged to the maximum degree, internal gas is dried, and the maximum efficacy of the chemical bulk drugs in the drying device is guaranteed.
[ description of the drawings ]
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
Fig. 1 is a schematic structural diagram of a chemical bulk drug drying device in an embodiment of the present application.
Fig. 2 is a usage state diagram of the chemical bulk drug drying device according to the embodiment of the present application.
Fig. 3 is a flow chart of a chemical bulk drug drying method according to an embodiment of the present application.
[ detailed description ] embodiments
In order to make the technical problems, technical solutions and advantageous effects solved by the present application more clear and obvious, the present application is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application.
As shown in fig. 1-2, the present application provides a method for drying a chemical raw material drug with nitrogen protection, which includes the following steps:
step S1: respectively assembling a vacuumizing device, a nitrogen conveying device, an oxygen concentration detector, an alarm device and a timing device with a drying device to build chemical raw material drying equipment;
step S2: placing the chemical bulk drug in a drying device, vacuumizing the drying device by a vacuumizing device, and closing the vacuumizing device and starting a nitrogen conveying device after the vacuum degree in the drying device reaches a set vacuum degree;
and step S3: after the drying device is filled with nitrogen, repeating the operation of the step S2 for N times, starting the drying device for heating and drying, simultaneously reducing the flow rate of the nitrogen conveying device to a set flow rate, closing the drying device after the timing device reaches the set time, and maintaining the set flow rate by the nitrogen conveying device so as to continuously introduce the nitrogen into the drying device;
in the step S3, when the oxygen concentration detector detects that the oxygen concentration in the drying device reaches the set concentration, the alarm device is triggered to alarm, and the nitrogen conveying device is regulated and controlled to increase the nitrogen conveying flow; the set concentration is 3-10%; the set flow rate in the step S3 is 0.05-0.2L/min; the number N of times in the step S3 is 1-3.
In the application, the drying device is vacuumized through the vacuumizing device, most of air in the drying device is pumped out, the nitrogen conveying device fills nitrogen into the drying device, after the drying device is filled with nitrogen, the gas in the drying device is diluted, the content of internal oxygen is reduced, the operations are repeated for 2 times, vacuumizing operation and nitrogen conveying operation are sequentially performed, the oxygen in the drying device is discharged to the maximum extent, drying operation is performed, meanwhile, the flow rate of the nitrogen conveying device is reduced to 0.1L/min, absolute sealing of the drying device is difficult to guarantee, absolute vacuum is difficult to achieve through the vacuumizing device, the oxygen concentration in the drying device is kept at a low level as far as possible through continuous nitrogen introduction and detection of the internal oxygen concentration, the reaction time of contact of chemical bulk drugs with oxygen or moisture is delayed, the service life of the chemical bulk drugs is greatly prolonged, and the maximum potency of the chemical bulk drugs is guaranteed.
A chemical bulk drug drying device with nitrogen protection comprises a drying device 1, a vacuumizing device 2 and a nitrogen conveying device 3, wherein the vacuumizing device 2 and the nitrogen conveying device 3 are communicated with the drying device 1, a containing cavity 11 for containing a chemical bulk drug is arranged in the drying device 1, the vacuumizing device 2 comprises a vacuumizing pump 21, a pipeline 22 communicated with the vacuumizing pump 21 and the containing cavity 11, and a first valve 23 arranged on the pipeline 22, a second valve 31 is arranged on the nitrogen conveying device 3, when the chemical bulk drug is placed in the containing cavity 11, the first valve 23 is opened, the vacuumizing pump 21 carries out vacuumizing operation, the first valve 23 is closed, the nitrogen conveying device 3 fills nitrogen into the containing cavity 11 when the second valve 31 is opened, the drying device 1 is opened after the containing cavity 11 is filled with nitrogen, when the drying device is used, the chemical bulk drug is placed in the containing cavity 11, the first valve 23 is opened, the vacuumizing operation is carried out by the vacuumizing device 21, when the vacuum degree in the containing cavity 11 reaches a set value, the first valve 23 is opened, the second valve 23 is opened, the drying device 2 is used for drying bulk drug, and the internal drying device 1 can discharge the maximum drying gas, and the drying degree of the chemical bulk drug is ensured.
The nitrogen conveying device 3 comprises a nitrogen storage tank 32, a communicating valve arranged on the nitrogen storage tank 32, and a conveying pipe 33 communicating the communicating valve with the accommodating cavity 11, the second valve 31 is arranged on the conveying pipe 33, the nitrogen conveying device 3 further comprises a flow meter 34 arranged on one side of the air outlet end of the second valve 31 and electrically connected with the communicating valve so as to detect the flow rate of nitrogen in the conveying pipe 33, and after the operation, because the flow meter is not in a completely closed state, the situations of nitrogen loss and oxygen entering may exist, and after the drying device 1 performs drying operation, the nitrogen conveying device 3 injects nitrogen into the accommodating cavity 11 at the flow rate of 0.1L/min so as to prevent the chemical bulk drugs from being oxidized.
The chemical bulk drug drying device further comprises a vacuum degree meter 4 which is arranged on the drying device 1 and is communicated with the accommodating cavity 11, wherein the vacuum degree meter 4 is electrically connected with the vacuum-pumping pump 21 so as to detect the vacuum degree in the accommodating cavity 11 and control the vacuum-pumping pump 21 to be turned on/off, and the actual extraction condition of the vacuum-pumping device 2 can be ensured so as to ensure the actual condition of internal vacuum pumping.
The drying device 1 is further provided with an alarm device 5 and a timing device 6, the timing device 6 is respectively electrically connected with the drying device 1 and the alarm device 5, the timing device 6 closes the drying device 1 when timing is finished and triggers the alarm device 5 to give an alarm, the drying device 1 can be controlled to be closed in time, the influence of over-drying on the drug potency of the chemical raw drug is avoided, and an operator can be reminded to perform the next operation.
This chemical bulk drug drying device is still including installing in oxygen concentration detector 7 in holding chamber 11, oxygen concentration detector 7 respectively with alarm device 5 with flowmeter 34 electricity is connected, oxygen concentration detector 7 detects the oxygen concentration in holding chamber 11, and with detecting signal transmission to alarm device 5 with flowmeter 34, in order to trigger alarm device 5 reports to the police, nitrogen gas conveyor 3 increases/maintains nitrogen gas delivery flow, and it can detect the oxygen in holding chamber 11, and when detecting oxygen concentration rise, it probably has the leakage of external oxygen, sets up oxygen concentration detector 7, and it can avoid chemical bulk drug to contact too much oxygen, guarantees the maximum effect of medicine.
The drying device 1 comprises a drying box body 12 and a cover body 13 covering the drying box body 12, the accommodating cavity 11 is arranged in the drying box body 12, a sealing rubber ring 14 is arranged on one side, facing the drying box body 12, of the cover body 13, a sealing environment is formed in the drying box body 12 to the greatest extent, and leakage of internal and external gases is avoided; the cover body 13 is also provided with a handle 15 for grasping, and the handle 15 is 7-shaped, so that an operator can conveniently open/close the drying device 1; still be equipped with an observation port 16 on the lid 13, observation port 16 is the translucent cover body, and the inside medicine state of the audio-visual observation of operating personnel of being convenient for need not frequently to open/close drying device 1 avoids medicine and the too much contact of air.
In summary, the present application has, but is not limited to, the following beneficial effects:
the invention relates to chemical bulk drug drying equipment with nitrogen protection, which comprises a drying device 1, a vacuumizing device 2 and a nitrogen conveying device 3, wherein the vacuumizing device 2 and the nitrogen conveying device 3 are communicated with the drying device 1, an accommodating cavity 11 for accommodating a chemical bulk drug is arranged in the drying device 1, the vacuumizing device 2 comprises a vacuumizing pump 21, a pipeline 22 for communicating the vacuumizing pump 21 with the accommodating cavity 11, and a first valve 23 arranged on the pipeline 22, a second valve 31 is arranged on the nitrogen conveying device 3, when the chemical bulk drug is placed in the accommodating cavity 11, the first valve 23 is opened, and after the vacuumizing pump 21 carries out vacuumizing operation, the first valve 23 is closed, the nitrogen conveying device 3 fills nitrogen into the accommodating cavity 11 when the second valve 31 is opened, the drying device 1 is opened after the accommodating cavity 11 is filled with nitrogen, when in use, the chemical bulk drug is placed in the accommodating cavity 11, the first valve 23 is opened, the vacuumizing pump 21 carries out vacuumizing operation, when the accommodating cavity 11 is filled with nitrogen, the first valve 23 is closed, the first valve is opened, the first valve 23 is opened, the internal vacuum degree of the chemical bulk drug is opened, the drying device 3, the internal drying device can discharge the drying device 1, and the drying device can discharge the maximum drying effect of the chemical bulk drug, and the internal drying device is ensured.
The foregoing is illustrative of one or more embodiments provided in connection with the detailed description and is not intended to limit the disclosure to the particular forms disclosed. Similar or identical methods, structures, etc. as used herein, or several technical inferences or substitutions made on the concept of the present application should be considered as the scope of the present application.

Claims (10)

1. A drying method of chemical bulk drugs with nitrogen protection is characterized by comprising the following steps:
step S1: respectively assembling a vacuumizing device, a nitrogen conveying device, an oxygen concentration detector, an alarm device and a timing device with a drying device to build chemical raw material drying equipment;
step S2: placing the chemical bulk drug in a drying device, vacuumizing the drying device by a vacuumizing device, and closing the vacuumizing device and starting a nitrogen conveying device after the vacuum degree in the drying device reaches a set vacuum degree;
and step S3: and after the drying device is filled with nitrogen, repeating the operation of the step S2 for N times, starting the drying device to perform heating drying, simultaneously reducing the flow rate of the nitrogen conveying device to a set flow rate, closing the drying device after the timing device reaches the set time, and maintaining the set flow rate by the nitrogen conveying device so as to continuously introduce the nitrogen into the drying device.
2. The chemical bulk drug drying method with nitrogen protection as claimed in claim 1, wherein in step S3, when the oxygen concentration detector detects that the oxygen concentration in the drying device reaches a set concentration, an alarm device is triggered to alarm, and the nitrogen delivery device is regulated to increase the nitrogen delivery flow.
3. The method for drying a chemical bulk drug with nitrogen protection according to claim 2, wherein the set concentration is 3-10%.
4. The method for drying a chemical bulk drug with nitrogen protection according to claim 1, wherein the set flow rate in step S3 is 0.05-0.2L/min.
5. The method for drying a chemical bulk drug with nitrogen protection according to claim 1, wherein the number of times N in the step S3 is 1-3.
6. The utility model provides a chemical raw material medicine drying equipment with nitrogen protection, its characterized in that, includes drying device (1) and intercommunication evacuating device (2) and nitrogen gas conveyor (3) of drying device (1), be equipped with holding chamber (11) that are used for placing chemical raw material medicine in drying device (1), evacuating device (2) are including evacuation pump (21), intercommunication evacuation pump (21) with pipeline (22) in holding chamber (11) and install in first valve (23) on pipeline (22), be provided with second valve (31) on nitrogen gas conveyor (3), still be equipped with an observation mouth (16) on drying device (1).
7. The chemical bulk drug drying equipment with nitrogen protection function according to claim 6, wherein the nitrogen delivery device (3) comprises a nitrogen storage tank (32), a communication valve installed on the nitrogen storage tank (32), and a delivery pipe (33) communicating the communication valve with the accommodating cavity (11), the second valve (31) is installed on the delivery pipe (33), and the nitrogen delivery device (3) further comprises a flow meter (34) installed on one side of the air outlet end of the second valve (31) and electrically connected with the communication valve, so as to detect the flow rate of nitrogen in the delivery pipe (33).
8. The chemical bulk drug drying equipment with nitrogen protection according to claim 6, further comprising a vacuum degree meter (4) installed on the drying device (1) and communicated with the accommodating cavity (11), wherein the vacuum degree meter (4) is electrically connected with the vacuum pumping pump (21) so as to detect the vacuum degree in the accommodating cavity (11) and control the vacuum pumping pump (21) to be turned on/off.
9. The chemical bulk drug drying equipment with nitrogen protection as claimed in claim 6, wherein the drying device (1) is further provided with an alarm device (5) and a timing device (6), the timing device (6) is electrically connected with the drying device (1) and the alarm device (5) respectively, and the timing device (6) closes the drying device (1) when timing is over and triggers the alarm device (5) to give an alarm.
10. The chemical bulk drug drying device with nitrogen protection as claimed in claim 7 or 9, further comprising an oxygen concentration detector (7) installed in the accommodating chamber (11), wherein the oxygen concentration detector (7) is electrically connected to the alarm device (5) and the flow meter (34), respectively, and the oxygen concentration detector (7) detects the oxygen concentration in the accommodating chamber (11) and transmits a detection signal to the alarm device (5) and the flow meter (34) to trigger the alarm device (5) to alarm and the nitrogen delivery device (3) to increase/maintain the nitrogen delivery flow.
CN202211421947.0A 2022-11-14 2022-11-14 Chemical bulk drug drying method and drying equipment with nitrogen protection Pending CN115900245A (en)

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CN202211421947.0A CN115900245A (en) 2022-11-14 2022-11-14 Chemical bulk drug drying method and drying equipment with nitrogen protection

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Application Number Priority Date Filing Date Title
CN202211421947.0A CN115900245A (en) 2022-11-14 2022-11-14 Chemical bulk drug drying method and drying equipment with nitrogen protection

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CN115900245A true CN115900245A (en) 2023-04-04

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000043717A1 (en) * 1999-01-22 2000-07-27 Heatwave Systems International Pty. Ltd. Drying apparatus and methods
CN208238401U (en) * 2018-05-18 2018-12-14 陶國君 A kind of medicinal raw material baking oven
CN209445733U (en) * 2018-12-13 2019-09-27 天津药物研究院药业有限责任公司 A kind of medicinal drying box
CN210861961U (en) * 2019-11-11 2020-06-26 艾希尔(深圳)药物研发有限公司 Vacuum drying oven
CN213542981U (en) * 2020-10-10 2021-06-25 上海耀大生物科技有限公司 Multifunctional vacuum drying oven for drug analysis
CN218821336U (en) * 2022-11-14 2023-04-07 广东岭南制药有限公司 Chemical raw material medicine drying device with nitrogen protection

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000043717A1 (en) * 1999-01-22 2000-07-27 Heatwave Systems International Pty. Ltd. Drying apparatus and methods
CN208238401U (en) * 2018-05-18 2018-12-14 陶國君 A kind of medicinal raw material baking oven
CN209445733U (en) * 2018-12-13 2019-09-27 天津药物研究院药业有限责任公司 A kind of medicinal drying box
CN210861961U (en) * 2019-11-11 2020-06-26 艾希尔(深圳)药物研发有限公司 Vacuum drying oven
CN213542981U (en) * 2020-10-10 2021-06-25 上海耀大生物科技有限公司 Multifunctional vacuum drying oven for drug analysis
CN218821336U (en) * 2022-11-14 2023-04-07 广东岭南制药有限公司 Chemical raw material medicine drying device with nitrogen protection

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