CN115887903A - Microneedle patch drug delivery assembly and drug delivery method - Google Patents

Abstract

A microneedle patch drug delivery assembly and a drug delivery method relate to the technical field of microneedle drug delivery, and are used for acquiring microneedle patches one by one and adding drugs into microneedles. The patch storage module comprises a storage cylinder and a shell which are arranged inside and outside, one end of the storage cylinder is provided with a storage cavity, the other end of the storage cylinder is provided with a plug hole, and the plug hole is communicated with the storage cavity through a taking-out hole; the patch acquisition module comprises a handheld cylinder body, a sliding block, a telescopic unit and a negative pressure generation device, wherein one end of the handheld cylinder body is detachably connected with the insertion hole, and the other end of the handheld cylinder body is detachably connected with the dosing box; the slider slides and sets up in the one end of handing the barrel, and flexible unit is located the removal of ordering about the slider in handing the barrel, and slider one end tip has the sucking disc, and negative pressure generating device is located handheld barrel and is connected with the sucking disc, makes the sucking disc adsorb the micropin paster under the negative pressure generating device effect. The invention can realize the one-by-one acquisition of the microneedle patches and the dosing of the microneedles.

Description

Microneedle patch drug delivery assembly and drug delivery method

Technical Field

The invention relates to the technical field of microneedle drug delivery, in particular to a microneedle patch drug delivery assembly and a drug delivery method.

Background

The microneedle is in an injection form, and can promote the absorption of the drug into the skin. When the microneedle patch is used for drug delivery in the prior art, a drug is first added to the microneedle, and then the microneedle patch is attached to the skin. The micro-needle patch is characterized in that the micro-needle patch is provided with a micro-needle, wherein the micro-needle is connected with the micro-needle, and the micro-needle is connected with the micro-needle. When the microneedle patch is small, it is not easy to take the microneedle patch and add drugs into the microneedle.

Disclosure of Invention

The invention aims to provide a microneedle patch drug delivery assembly and a drug delivery method, which are used for acquiring microneedle patches one by one and adding drugs into microneedles.

The technical scheme adopted by the invention for solving the technical problems is as follows: the microneedle patch administration assembly comprises a patch storage module, a patch acquisition module and an administration box, wherein the patch storage module comprises a storage cylinder and a shell which are arranged inside and outside, the storage cylinder is in threaded connection with the shell, one end of the storage cylinder is provided with a storage cavity for placing a microneedle patch, the other end of the storage cylinder is provided with an insertion hole, the insertion hole is communicated with the storage cavity through a taking hole, and the inner diameter of the taking hole is smaller than that of the storage cavity; the medicine adding box is a hollow structure with one open end; the patch acquisition module comprises a handheld cylinder, a sliding block, a telescopic unit and a negative pressure generation device, wherein one end of the handheld cylinder is detachably connected with the insertion hole, and the other end of the handheld cylinder is detachably connected with the open end of the dosing box; the slider slides and sets up in the one end of handing the barrel, flexible unit is located handheld barrel and orders about the removal of slider, slider one end tip has the sucking disc, negative pressure generating device is located handheld barrel and is connected with the sucking disc, flexible unit effect orders about behind the one end of slider stretches into the storage intracavity negative pressure generating device effect makes the sucking disc adsorb the micropin paster.

Furthermore, the shell is of a hollow structure with one open end, the outer wall of the other end of the storage cylinder is provided with an external thread, and the external thread is in threaded connection with the inserting hole.

Further, a gasket is arranged on the inner side of the sealed end of the shell and is in contact with the micro-needles of the micro-needle patch.

Further, a plurality of suction holes are formed in the end face of one end of the sucker, side holes are formed in the end face of the other end of the sucker, and the suction holes and the side holes are communicated through a collecting cavity located in the sucker.

Further, be connected through the pipe connection between negative pressure generating device and the sucking disc, the pipeline includes hard tube and spiral helicine hose, the one end and the side opening intercommunication of hard tube, the other end of hard tube is connected with the one end of hose, the other end and the negative pressure generating device of hose are connected.

Furthermore, the telescopic unit comprises a motor, a gear fixed at the output end of the motor and a rack meshed with the gear, and the rack is fixedly connected with the sliding block.

Further, have first mounting panel and second mounting panel in the handheld barrel, the battery has between first mounting panel and the second mounting panel, negative pressure generating device fixes on first mounting panel, handheld barrel other end tip has the ultraviolet lamp.

Furthermore, a guide rail is fixed on the first mounting plate, and the rack is connected with the guide rail in a sliding mode.

Furthermore, the sucking holes are eccentrically arranged on the sucking disc, and the center of the sucking disc is provided with a rubber surface.

The invention also provides a drug delivery method of the microneedle patch, which comprises the following steps:

(1) Separating the handheld barrel from the dosing box, and adding a proper amount of medicine into the dosing box;

(2) Pushing the end part of one end of the sliding block into the storage cylinder through the telescopic unit, and starting the negative pressure adsorption device to enable the sucker to suck the microneedle patch;

(3) The slide block is moved out of the storage cylinder, and one end of the handheld cylinder body is connected with the dosing box in an inserting mode;

(4) After the handheld cylinder body is placed at the upper part and the dosing box is placed at the lower part for a period of time, the handheld cylinder body is separated from the dosing box, and the microneedle patch is attached to the surface of the skin to administer the drug.

The invention has the beneficial effects that: the microneedle patch storage module is arranged to store microneedle patches, and the microneedle patches are acquired one by one from the patch storage module through the arrangement of the patch acquisition module; the medicine is added into the medicine adding box, and after the patch obtaining module is connected with the open end of the medicine adding box, the micro-needle on the micro-needle patch is immersed in the medicine, so that the medicine can enter the micro-needle. The components of the invention are mutually matched to realize the one-by-one acquisition of the microneedle patches and the addition of the medicines, thereby being beneficial to the drug delivery of the microneedle patches.

Drawings

Figure 1 is a front view of a dosing assembly according to the invention;

FIG. 2 is a cross-sectional view of a patch storage module;

FIG. 3 is a three-dimensional view of the cartridge;

FIG. 4 is a front view of the patch acquisition module;

FIG. 5 is a schematic diagram of the internal structure of the patch acquisition module;

FIG. 6 is a cross-sectional view of a patch acquisition module;

FIG. 7 is a partial view of the portion of FIG. 5 from the A direction;

FIG. 8 is a three-dimensional perspective view of the suction cup;

FIG. 9 is a schematic view of the patch acquisition module extending into the patch storage module;

FIG. 10 is a cross-sectional view of the dosing cartridge;

fig. 11 is a schematic view of a microneedle patch placed within a kit;

FIG. 12 is a rear view of the present invention;

in the figure: the device comprises a shell, 11 stepped holes, 12 gaskets, 2 storage cylinders, 21 splicing holes, 22 storage cavities, 23 taking holes, 24 external threads, 3 handheld cylinders, 30 charging interfaces, 31 splicing ends, 32 thread mounting ends, 33 first switches, 34 second switches, 35 slider cavities, 36 first mounting plates, 37 second mounting plates, 38 partition plates, 39 positioning plates, 391 avoiding holes, 4 sliders, 41 sucker grooves, 42 suckers, 421 rubber surfaces, 422 sucking holes, 423 collecting cavities, 424 side holes, 43 hard tubes, 44 transitional connecting holes, 45 hoses, 46 negative pressure generating devices, 5 motors, 51 gears, 52 racks, 53 guide rails, 6 storage batteries, 7 ultraviolet lamps, 71 third switches, 8 medicine adding boxes, 81 internal threads, 82 limiting rings, 9 microneedle patches, 91 microneedles and 10 liquid medicines.

Detailed Description

As shown in fig. 1 to 12, the administration set of the present invention comprises a patch storage module, a patch retrieval module and a medicated cassette 8, and the present invention will be described in detail below with reference to the accompanying drawings.

As shown in fig. 1 to 12, the microneedle patch administration assembly includes a patch storage module, a patch acquisition module and a dosing box 8, the patch storage module includes an internal and external storage cylinder 2 and a housing 1, as shown in fig. 2 and 3, the storage cylinder 2 is a cylindrical structure, one end of the storage cylinder 2 is large, the other end is small, the housing 1 is a cylindrical structure with one end open, the inner side of the housing 1 is a step hole 11, and the large hole of the step hole 11 is located at one side of the open end of the housing 1. The step surface at the intersection of the two ends of the storage cylinder 2 is used for contacting with the step surface of the step hole 11, so that the storage cylinder 2 is positioned when being installed in the shell 1. As shown in fig. 3, the outer wall of one end of the storage cylinder 2 has an external thread 24, and the external thread 24 is engaged with the thread of the large hole of the stepped hole 11 to realize the threaded connection between the storage cylinder 2 and the housing 1. The inner side of one end of the storage cylinder 2 is provided with a plug hole 21, the inner side of the other end of the storage cylinder 2 is provided with a storage cavity 22, and the storage cavity 22 is used for storing and placing the microneedle patch 9. The inserting hole 21 is communicated with the storage cavity 22 through the taking-out hole 23, the inner diameter of the taking-out hole 23 is smaller than that of the storage cavity 22, and the inner diameter of the storage cavity 22 is smaller than that of the inserting hole 21. The inner cavity of the whole storage cylinder 2 forms an inserting hole 21, a taking-out hole 23 and a storage cavity 22 which are sequentially arranged and communicated along the axial direction, when the microneedle patch holder is used, the storage cylinder 2 is separated from the shell 1, then the microneedle patch 9 is neatly stacked and placed in the storage cavity 22, and the inner diameter of the storage cavity 22 is slightly larger than the outer diameter of the microneedle patch 9, so that the microneedle patch 9 can move in the storage cavity 22. The inner diameter of the taking-out hole 23 is smaller than the inner diameter of the storage cavity 22 and slightly smaller than the outer diameter of the microneedle patch 9, so that the microneedle patch 9 can be prevented from entering the insertion hole 21 through the taking-out hole 23. The inner wall of the other end (i.e. the sealing end) of the housing 1 is provided with a flexible gasket 12, and the gasket 12 is arranged so that the microneedles 91 of the microneedle patch 9 are protected after contacting the gasket 12.

As shown in fig. 10, the medicine adding box 8 is a hollow structure with an open end, the inner wall of one end of the medicine adding box 8 is provided with an internal thread 81, and the inner wall of the middle part of the medicine adding box 8 is provided with a circular limiting ring 82.

As shown in fig. 4 to 9, the patch acquiring module includes a handheld barrel 3, a slider 4, a telescopic unit and a negative pressure generating device 46, the handheld barrel 3 is a cylindrical structure, as shown in fig. 4, one end of the handheld barrel 3 is a plugging end 31, and the plugging end 31 is used for being plugged and connected with the plugging hole 21. The outer wall of the insertion end 31 is rough, so that after the insertion end 31 is inserted into the insertion hole 21, a large friction force exists between the handheld barrel body 3 and the storage barrel 2, and the storage barrel 2 and the handheld barrel body 3 cannot be easily separated. The other end of the handheld barrel 3 is a thread mounting end 32, and the thread mounting end 32 is used for being matched with an internal thread 81 at the open end of the dosing box 8, so that the thread mounting end 32 is in threaded connection with the dosing box 8. As shown in fig. 5, the inner side of one end of the handheld barrel 1 is a circular slider cavity 35, and the cylindrical slider 4 is slidably mounted in the slider cavity 35. As shown in fig. 6, the slider 4 is a hollow structure with an open end, one end of the slider 4 is located in the slider cavity 35, the other end of the slider 4 extends out of one end of the handheld cylinder 3 (i.e. the slider cavity 35), and the telescopic unit is located in the handheld cylinder 3 to drive the slider 4 to move. As shown in fig. 6, the telescopic unit includes a motor 5, a gear 51 fixed at an output end of the motor 5, and a rack 52 engaged with the gear 51, wherein one end of the rack 52 extends into the slider 4 and is fixedly connected with the slider 4. In order to ensure the meshing precision of the gear 51 and the rack 52, the handheld barrel 3 is internally provided with a first mounting plate 36 and a second mounting plate 37, a guide rail 53 is fixed on the first mounting plate 36, and the other end of the rack 52 extends into the guide rail 53 and is in sliding connection with the guide rail 53. In order to supply electric energy to the motor 5, the first mounting plate 36 and the second mounting plate 37 are provided with the storage battery 6 therebetween, and the storage battery 6 is electrically connected with the motor 5.

As shown in fig. 7, a circular suction cup groove 41 is formed in the end surface of the other end of the slider 4, and a suction cup 42 is formed in the suction cup groove 41, as shown in fig. 8, the suction cup 42 has a circular structure, a plurality of eccentrically arranged suction holes 422 are formed in the end surface of one end of the suction cup 42, and the suction holes 422 are uniformly arranged on the same circumference. The end surface of one end of the suction cup 42 is also provided with a glue surface 421, and the glue surface 421 is positioned at the center of the suction cup 42. The suction cup 42 has a side hole 424 on the end surface at the other end, and the suction hole 422 and the side hole 424 are communicated with each other through a collection chamber 423 in the suction cup 42. One end of the sliding block 4 is provided with a transition connecting hole 44, and after the suction cup 42 is placed in the suction cup groove 41, the side hole 424 is communicated with the transition connecting hole 44. A pipeline is arranged between the negative pressure generating device 46 and the transition connecting hole 44, the pipeline comprises a hard pipe 43 and a hose 45, one end of the hard pipe 43 is communicated with the transition connecting hole 44, the other end of the hard pipe 43 is connected with one end of the hose 45, and the other end of the hose 45 is connected with the negative pressure generating device 45. The hose 45 is a spiral tube, and when the slider 4 moves in the slider cavity 35, the spiral design of the hose 45 can be extended and retracted. The first mounting plate 36 is fixed with a negative pressure generating device 46, the first mounting plate 36 is also vertically provided with a partition plate 38, one end of the partition plate 38 is in contact with the first mounting plate 36, the other end of the partition plate 38 is fixed with a positioning plate 39, and the positioning plate 39 is fixed in the inner cavity of the handheld barrel 3. The positioning plate 39 is provided with an avoiding hole 391, and the avoiding hole 391 is used for avoiding the hose 45 and the hard tube 43 so as to facilitate the passing of the hose 45 and the hard tube 43. The negative pressure generating device 46 is electrically connected to the battery 6.

Under the non-use state, in order to realize the disinfection to adding medicine box 8, handheld barrel 3 other end tip has ultraviolet lamp 7. The ultraviolet lamp 7 is electrically connected with the storage battery 6, and after the ultraviolet lamp 7 is turned on, the medicine adding box 8 is disinfected.

As shown in fig. 4, the outer wall of the handheld barrel 3 is provided with a first switch 33, a second switch 34 and a third switch 71, the first switch 33 is used for controlling the working state of the motor 5, the second switch 34 is used for controlling the working state of the negative pressure generating device 46, and the third switch 71 is used for controlling the working state of the ultraviolet lamp 7. As shown in fig. 12, the outer wall of the handheld barrel 3 further has a charging interface 30 to facilitate charging of the storage battery 6.

The method of use of the invention is described below:

(1) When the handheld barrel 3 needs to be separated from the patch storage module, the handheld barrel 3 is pulled out forcibly, so that the handheld barrel 3 is separated from the storage barrel 2;

(2) When the handheld cylinder 3 needs to be separated from the medicine adding box 8, the separating box 8 is rotated;

(3) When the microneedle patch 9 needs to be obtained, as shown in fig. 9, the first switch 33 is pressed down to make the slider 4 extend out of the handheld barrel 3 by a section, then the slider 4 extends into the storage cylinder 2 to make the suction cup 42 contact with the microneedle patch 9, the second switch 34 is pressed down to make the suction cup 42 suck the microneedle patch 9, and then one end of the slider 4 is moved out of the storage cylinder 2;

(4) When the micro-needle 91 needs to be dosed, as shown in fig. 11, a certain amount of medicine 10 is added into the dosing box 8, the insertion end 31 is inserted into the dosing box 8, when the insertion end 31 contacts the limiting ring 82, it is shown that the handheld cylinder 3 and the dosing box 8 are assembled in place, and at this time, the needle point of the micro-needle 91 is immersed in the medicine 10, and the medicine enters the micro-needle 91 under the capillary phenomenon principle.

The invention also provides a drug delivery method of the microneedle patch, which comprises the following steps:

(1) Separating the handheld cylinder 3 from the medicine adding box 8, and adding a proper amount of medicine 10 into the medicine adding box 8;

(2) Pushing the end part of one end of the sliding block 4 into the storage cylinder 2 through the telescopic unit, and starting the negative pressure adsorption device 46 to enable the sucker 42 to suck the microneedle patch 9;

(3) The slide block 4 is moved out of the storage cylinder 2, and one end of the handheld cylinder body 3 is connected with the dosing box 8 in an inserting mode;

(4) After the handheld cylinder 3 is placed at the upper part and the dosing box 8 is placed at the lower part for a period of time, the handheld cylinder 3 is separated from the dosing box 8, and the microneedle patch 9 is attached to the surface of the skin to administer the drug.

The microneedle patch storage module is arranged to store microneedle patches, and the microneedle patches are acquired one by one from the patch storage module through the arrangement of the patch acquisition module; the medicine is added into the medicine adding box, and after the patch obtaining module is connected with the open end of the medicine adding box, the micro-needle on the micro-needle patch is immersed in the medicine, so that the medicine can enter the micro-needle. The components of the invention are mutually matched to realize the one-by-one acquisition of the microneedle patches and the addition of the medicines, thereby being beneficial to the drug delivery of the microneedle patches.

Claims (10)

1. The microneedle patch administration assembly is characterized by comprising a patch storage module, a patch acquisition module and an administration box, wherein the patch storage module comprises a storage cylinder and a shell which are arranged inside and outside, the storage cylinder is in threaded connection with the shell, one end of the storage cylinder is provided with a storage cavity for placing a microneedle patch, the other end of the storage cylinder is provided with an insertion hole, the insertion hole is communicated with the storage cavity through a taking-out hole, and the inner diameter of the taking-out hole is smaller than that of the storage cavity; the medicine adding box is a hollow structure with one open end; the patch acquisition module comprises a handheld cylinder, a sliding block, a telescopic unit and a negative pressure generation device, wherein one end of the handheld cylinder is detachably connected with the insertion hole, and the other end of the handheld cylinder is detachably connected with the open end of the dosing box; the slider slides and sets up in the one end of handheld barrel, flexible unit is located handheld barrel and orders about the removal of slider, slider one end tip has the sucking disc, negative pressure generating device is located handheld barrel and is connected with the sucking disc, flexible unit effect orders about after the one end of slider stretches into the storage intracavity negative pressure generating device effect makes the sucking disc adsorb the micropin paster.

2. A microneedle patch delivery assembly according to claim 1, wherein the housing is a hollow structure with one end open, and the outer wall of the other end of the storage cylinder has an external thread, and the external thread is in threaded connection with the insertion hole.

3. A microneedle patch delivery assembly according to claim 2, wherein said housing has a gasket on the inside of the closed end, said gasket contacting the microneedles of the microneedle patch.

4. A microneedle patch delivery assembly according to claim 1, wherein the suction cup has a plurality of suction holes on an end face at one end thereof, and a side hole on an end face at the other end thereof, the suction holes and the side hole being in communication via a collection chamber located in the suction cup.

5. A microneedle patch delivery assembly according to claim 4, wherein the negative pressure generating device is connected with the suction cup through a pipe, the pipe comprises a hard pipe and a spiral hose, one end of the hard pipe is communicated with the side hole, the other end of the hard pipe is connected with one end of the hose, and the other end of the hose is connected with the negative pressure generating device.

6. A microneedle patch delivery assembly according to claim 5, wherein the telescopic unit comprises a motor, a gear fixed at an output end of the motor, and a rack engaged with the gear, and the rack is fixedly connected with the slider.

7. A microneedle patch delivery assembly according to claim 6, wherein the hand-held cylinder has a first mounting plate and a second mounting plate therein, a storage battery is provided between the first mounting plate and the second mounting plate, the negative pressure generating device is fixed on the first mounting plate, and an ultraviolet lamp is provided at the other end of the hand-held cylinder.

8. A microneedle patch delivery assembly according to claim 7, wherein a guide rail is further fixed to the first mounting plate, and the rack is slidably connected to the guide rail.

9. A microneedle patch delivery assembly according to claim 4, wherein said suction holes are provided in plurality eccentrically on a suction cup having an adhesive face in its center.

10. A method of administering a microneedle patch delivery assembly according to any one of claims 1 to 9, comprising the steps of:

(1) Separating the handheld cylinder body from the dosing box, and adding a proper amount of medicine into the dosing box;

(2) Pushing the end part of one end of the sliding block into the storage cylinder through the telescopic unit, and starting the negative pressure adsorption device to enable the sucker to suck the microneedle patch;

(3) The slide block is moved out of the storage cylinder, and one end of the handheld cylinder body is connected with the dosing box in an inserting mode;

(4) After the handheld cylinder body is placed at the upper part and the dosing box is placed at the lower part for a period of time, the handheld cylinder body is separated from the dosing box, and the microneedle patch is attached to the surface of the skin to administer the drug.

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