CN115886920A - Stent, embolic device and interventional system - Google Patents

Abstract

The invention provides a stent, an embolization device and an interventional system. The bracket comprises a bracket body and a plurality of fixing pieces; the proximal end of the stent body is folded into the fixing piece to avoid the bare end from puncturing the aneurysm. And the mounting is close to towards the interlude to make the relative interlude of near-end sunken, not contact with tumor cavity wall, improve blood flow direction effect and shutoff effect. Furthermore, the far end can be folded into the fixing piece, and the near end and the far end are both in a concave shape so as to avoid impacting the tumor cavity. And the stent body is formed by weaving a plurality of weaving wires, at least part of the weaving wires are reversely woven after being woven to the near end and the far end and extend to the middle section, so that the metal coverage rate of the near end and the far end is increased, the plugging effect of the near end is improved, the endothelialization is accelerated to be generated, the supporting force of the far end and the near end is enhanced, and the stability and the anchoring property of the stent are improved. Meanwhile, the middle section has certain radial supporting force, and the metal coverage rate is lower, so that the flexibility and the adherence of the stent are ensured.

Description

Stent, embolic device and interventional system

Technical Field

The invention relates to the technical field of medical instruments, in particular to a stent, an embolization device and an interventional system.

Background

Aneurysms are the manifestations of localized or diffuse dilatation or bulging of the arterial wall due to lesions or lesions of the arterial wall, and are common cardiovascular and cerebrovascular diseases. Aneurysms can occur anywhere in the arterial system. Once the aneurysm is ruptured, serious consequences can be caused, such as rupture of intracranial aneurysm, subarachnoid hemorrhage, vasospasm of severe patients can be caused to cause large-scale cerebral infarction, and further hemiplegia and coma, hemorrhagic shock or serious intracranial hypertension are caused, and the death rate is extremely high. The current treatment options for aneurysms are primarily open surgical and endovascular interventions. Open surgical treatment schemes require opening the body cavity that encloses the aneurysm, such as craniotomy and thoracotomy, causing significant damage to the patient's body and long post-operative recovery periods. The intravascular interventional therapy of the aneurysm becomes the preferred clinical treatment scheme of many medical experts at present due to the advantages of minimal invasion, safety and effectiveness.

The current clinical major vascular intervention techniques include stent assisted coil embolization, blood flow guide placement, and covered stent placement. Stent assisted coil embolization can alter the hemodynamic state of the aneurysm and act as a "scaffold" for vascular endothelial growth. The stent-assisted spring ring embolization interventional operation also has higher risk and high cost, the operation needs to fill the aneurysm cavity by passing a microcatheter through a stent mesh to convey a spring ring, the operation difficulty of passing the microcatheter through a stent gap is very high, vascular tissues are easy to puncture, so the risk is higher, the cost is also higher, and meanwhile, the risk of relapse and rupture exists after the aneurysm operation. The blood flow guiding device mainly utilizes the change of blood flow in the parent artery at the neck of the aneurysm, greatly reduces the blood flow entering the aneurysm, and simultaneously ensures the smoothness of branch vessels. However, there is also a risk of occluding other fine branches if the stent metal coverage is too high. The therapeutic principle of stent graft is to isolate the blood flow in the aneurysm and induce thrombosis in the aneurysm. While stent grafts can occlude blood flow in an aneurysm, they risk blocking normal blood flow by covering other branch arteries of the blood vessel, thereby causing post-operative stroke complications. Meanwhile, due to the adoption of the covered stent, the flexibility of the conveying system is not enough, the capability of the conveying system for treating intracranial tortuous vascular diseases is limited, and the application range is limited.

Therefore, a new interventional device is needed to solve the above problems.

Disclosure of Invention

The invention aims to provide a stent, an embolization device and an interventional system, so as to solve at least one problem of reducing the influence on a parent artery and improving the treatment effect of aneurysm.

In order to solve the technical problem, the invention provides a bracket, which comprises a bracket body and a plurality of fixing pieces; the proximal end of the stent body is connected with at least one fixing piece, at least part of the stent body is bound in the fixing piece, and the fixing piece is close to the middle section of the stent body so that the proximal end is sunken relative to the middle section;

the stent body is formed by weaving a plurality of weaving wires, and at least part of the weaving wires are reversely woven after being woven to the near end and the far end of the stent body and extend to the middle section.

Optionally, in the stent, when the number of the fixing elements is greater than or equal to 2, the distal end is connected with at least one fixing element and is bound in the fixing element, and the fixing element approaches towards the middle section of the stent body, so that the distal end is recessed relative to the middle section.

Optionally, in the stent, the connection between the proximal end and the distal end and the fixing member includes: welding or medical glue bonding.

Optionally, in the stent, the porosity of the proximal and distal ends is less than the porosity of the intermediate section.

Optionally, in the stent, the range covered by the reverse braiding at the two opposite ends of the middle section respectively occupies 1/4 to 1/3 of the outer surface of the middle section.

Optionally, in the stent, at least some of the braided filaments are braided back and forth between the proximal end and the intermediate section, and between the distal end and the intermediate section.

Optionally, in the stent, the braided wire has 48 to 288 strands.

Optionally, in the stent, the stent body is a self-expanding braided stent having an expanded state and a compressed state; and in the expanded state, the outer profile of the intermediate section is arcuate or cylindrical.

Optionally, in the stent, in the expanded state, the maximum diameter of the stent body ranges from 3mm to 16mm.

Optionally, in the stent, in the expanded state, the middle section is fitted to a tumor lumen wall, and the proximal end faces the blood vessel to close off a tumor orifice.

Optionally, in the stent, the stent body includes a developing member, and the developing member is woven into a mesh with the woven wire.

Optionally, in the stent, the developing member comprises the braided wire and a developing coil; the developing coil is wound on the weaving wire and covers at least part of the weaving wire.

Optionally, in the bracket, the developing coil material includes one or more of platinum-tungsten alloy, platinum-iridium alloy, pure platinum, gold, and tantalum wire.

Optionally, in the bracket, the fixing member includes: the ring, the dome and the spiral pipe fitting, just the material of mounting includes development material.

Based on the same inventive concept, the invention also provides an embolism device which comprises a conveying rod and the bracket, wherein the bracket is connected with the conveying rod through a release wire.

Based on the same inventive concept, the invention also provides an interventional system, which comprises a microcatheter, a micro guide wire and the embolism device, wherein the microcatheter and the micro guide wire are used for conveying the embolism device.

In summary, the present invention provides a stent, an embolization device and an interventional system. The stent is used for plugging aneurysm and comprises a stent body and a plurality of fixing pieces, and the near end of the stent body is folded into the corresponding fixing pieces so as to prevent the bare end of the stent body from puncturing aneurysm cavities. Simultaneously, the fastener approaches towards the midsection, so that the proximal end is recessed relative to the midsection. Furthermore, the far end of the stent body can be bound in the fixing piece, so that the near end and the far end are both in a concave shape and are not in contact with the tumor cavity wall, and the far end is prevented from impacting the tumor cavity. The stent body is formed by weaving a plurality of weaving wires, at least part of the weaving wires are reversely woven after being woven to the near end and the far end and extend to the middle section, so that the metal coverage rate of the near end and the far end is increased, the blood flow guiding effect and the blocking effect of the near end are better played, the endothelialization of the near end is accelerated, and the aneurysm treatment effect is favorably improved; and the supporting force of the near end is enhanced, and the stability of the bracket is improved. Simultaneously, the interlude has certain radial holding power, and the metal coverage is lower, and the porosity is higher to can guarantee the compliance and the adherence of support.

Therefore, the stent, the embolization device and the interventional system provided by the invention not only can avoid the influence on the parent artery, but also can improve the treatment effect of the aneurysm.

Drawings

Fig. 1 is a schematic structural view of a first bracket according to an embodiment of the present invention.

FIG. 2 is a schematic representation of a first stent positioned in a tumor lumen in an embodiment of the present invention.

FIG. 3 is a schematic longitudinal sectional view of a developing member in the embodiment of the present invention.

Fig. 4 is a schematic view of the structure of the proximal end of the stent in an embodiment of the invention.

Fig. 5 is a schematic view of the distal end of a stent in an embodiment of the invention.

Fig. 6 is a schematic structural view of a second bracket according to an embodiment of the present invention.

FIG. 7 is a schematic structural view of a third stent in an embodiment of the present invention.

FIG. 8 is a schematic representation of a third stent positioned in the lumenal of an embodiment of the present invention.

Fig. 9 is a schematic structural view of a fourth stent in an embodiment of the present invention.

Wherein the drawings are described as follows:

10-a stent body; 101-a proximal end; 102-an intermediate section; 103-a distal end; 20-a fixing member; 30-an aneurysm; 40-blood vessels; a-weaving silk; b-a developing member; b 1-weaving filaments in the developing member; b 2-developing coil.

Detailed Description

To further clarify the objects, advantages and features of the present invention, a more particular description of the invention will be rendered by reference to specific embodiments thereof which are illustrated in the appended drawings. It is to be noted that the drawings are in simplified form and are not to scale, but are provided for the purpose of facilitating and clearly illustrating embodiments of the present invention. Further, the structures illustrated in the drawings are often part of actual structures. In particular, the drawings are intended to show different emphasis, sometimes in different proportions. It should also be understood that the terms "first," "second," "third," and the like in the description are used for distinguishing between various components, elements, steps, and the like, and not for describing a sequential or logical relationship between various components, elements, steps, or the like, unless otherwise specified or indicated.

The definitions of "proximal" and "distal" herein are: "distal" generally refers to the end of the medical device that first enters the patient during normal operation, while "proximal" generally refers to the end of the medical device that is near the operator during normal operation.

In order to solve the above technical problem, the present embodiment provides a bracket. Referring to fig. 1, the bracket includes a bracket body 10 and a plurality of fixing members 20; the proximal end 101 of the stent body is connected with at least one fixing piece 20, at least part of the stent body 10 is restrained in the fixing piece 20, the fixing piece 20 approaches to the middle section 102 of the stent body 10, so that the proximal end 101 is recessed relative to the middle section 102; the stent body 10 is formed by weaving a plurality of weaving wires a, and at least some of the weaving wires a are woven to the proximal end 101 and the distal end 103 of the stent body 10, then are woven in opposite directions, and extend to the middle section 102.

The stent provided by the embodiment can relieve the influence on the parent artery and improve the treatment effect of the aneurysm. The support provided in this embodiment is described in detail below with reference to fig. 1-6.

Referring to fig. 1-2, the stent provided in this embodiment is used in a blood vessel containing an aneurysm 30 to occlude the aneurysm. The stent comprises a stent body 10 and a plurality of fixing pieces 20. Wherein, the bracket body 10 is provided with a proximal end 101, a middle section 102 and a distal end 103 which are connected in sequence. Further, the stent body 10 is a woven stent having self-expanding characteristics, has an expanded state and a compressed state, and is woven by a plurality of weaving filaments a. Optionally, the stent body 10 is woven by 48 to 288 knitting filaments a to form a mesh structure, for example, 48 knitting filaments a or 144 knitting filaments a are selected, which is not limited in this embodiment. Further, the knitting filaments a are knitted from a middle position toward both sides to form a tubular knitting structure, and when the knitting filaments a are knitted to the proximal end 101 and the distal end 103, at least a part of the knitting filaments a are reversely knitted until extending to the middle section 102, which aims to increase the metal coverage of the proximal end 101 and the distal end 103 and reduce the porosity. Of course, according to the specific porosity requirement, all the knitting filaments a may be knitted in the reverse direction, or a part of the knitting filaments a may be knitted in the reverse direction, or at least a part of the knitting filaments a may be knitted back and forth between the proximal end 101 and the middle section 102, and between the distal end 103 and the middle section 102, so as to increase the metal coverage of the proximal end 101 and the distal end 103 and reduce the porosity.

The reverse knitting is a knitting in which the knitting yarn a is folded back after being knitted to the proximal end 101 or the distal end 103 and then knitted toward the intermediate section 102. The back and forth knitting refers to knitting in which the knitting yarn a is folded back from the proximal end 101 or the distal end 103 and then knitted toward the intermediate section 102, and then folded back again and knitted toward the proximal end 101 or the distal end 103 after reaching the intermediate section 102, and thus the knitting is repeated. Furthermore, when the folding is carried out each time, part of the knitting silk a at part of the positions is selected to continue knitting, or all the knitting silk a is folded and knitted, so that the requirements of different porosities are met.

Based on this, the metal coverage of the proximal end 101 and the distal end 103 of the stent body 10 is greater than the middle section 102, and the porosity of the proximal end 101 and the distal end 103 is less than the middle section. As shown in fig. 2, after the stent is implanted in the aneurysm 30, the distal end 103 extends into the interior of the aneurysm 30, the middle section 102 fits against the aneurysm cavity wall of the aneurysm 30, and the proximal end 101 seals off at the aneurysm opening, facing the blood vessel 40. It can be appreciated that the proximal end 101 is reverse woven to increase metal coverage and reduce porosity for the purpose of enhancing blood flow guidance and improving occlusion. Namely, the higher metal coverage can accelerate the intimal hyperplasia of the neck of the tumor, induce the thrombosis of the neck of the tumor and improve the plugging effect; and guiding the blood flow in the blood vessel 40 to flow along the extending direction of the blood vessel, so as to avoid the damage of the aneurysm 30 rupture caused by the blood flow in the blood vessel 40 impacting into the aneurysm 30. Similarly, the distal end 103 is woven reversely to increase the metal coverage and reduce the porosity, and the proliferated intima is also used to improve the anchoring property of the stent body 10, thereby avoiding other complications caused by displacement or slipping of the stent body 10. In addition, the increased metal coverage of the distal end 103 also enhances the supporting force of the stent body 10.

The metal coverage of the intermediate section 102 is smaller than that of the proximal end 101 and the distal end 102, and the porosity of the intermediate section 102 is larger than that of the proximal end 101 and the distal end 102, so as to ensure the flexibility and adherence of the intermediate section 102. The intermediate section 102 is adapted to expand rapidly when the expansion state is changed from the compressed state to the expanded state, and is attached to the wall of the tumor cavity to stabilize the stent and ensure the occlusion effect. Therefore, the intermediate section 102 needs to have good anchoring and compliance. The porosity of the middle section 102 provided by this embodiment is greater than the porosity of the proximal end 101 and the distal end 103, so as to ensure the adherence and anchoring property of the middle section 102, prevent the stent body 10 from slipping and falling off from the aneurysm 30, and the middle section 102 also has self-elasticity, and can be applied to the corresponding aneurysm 30 more gently. In addition, the middle section 102 also needs to have radial supporting force to ensure the adherence effect. Therefore, the opposite ends of the middle section 102 are covered by the reverse braiding to occupy 1/4 to 1/3 of the outer surface of the middle section 102. In other words, the braided wires braided in the proximal end 101 and the distal end 103 of the stent body 10 in opposite directions extend and braid onto the middle section 102, and the metal coverage of the two ends of the middle section 102, which are connected with the proximal end 101 and the distal end 103, is correspondingly increased, so as to improve the radial supporting force of the middle section 102. To ensure compliance of the intermediate section 102, the reverse braid wires do not completely cover the intermediate section 102. Thus, the surface area of the reverse-knitted filaments covering either end of the intermediate section 102 is only 1/4 to 1/3 of the total surface area of the intermediate section 102. For example, if the middle section 102 is cylindrical and has the same cross-section throughout, the axial length of the area covered by the reverse braided wires at the end of the middle section 102 near the proximal end 101 is 1/4 of the total axial length of the middle section 102. Further, barbs are disposed on the middle section 102 to further improve the anchoring property of the stent body 10.

Referring to fig. 3 to 5, the braided wire a is made of a biocompatible material containing nickel, titanium, and other elements and having a shape memory property, including but not limited to nickel-titanium alloy, cobalt-chromium alloy, tantalum wire, or a noble metal material and a composite material having a developing effect. In addition, the stent body 10 further includes a developing member b which is woven into a mesh structure with the weaving filaments a. Further, the developing member b includes the knitting yarn b1 and a developing coil b2; the developing coil b2 is wound on the weaving wire b1 and covers at least part of the weaving wire b1. The knitting yarn b1 in the developing member b is the same as the knitting yarn a of the knitted stent body 10. Referring to the sectional view of the developing member b shown in fig. 3, the developing coil b2 is fixed to the weaving wire b1 in the form of a wound spring. Alternatively, the developing coil b2 completely covers the knitting wire b1 along the axial direction of the knitting wire b1, that is, the outer surface of the knitting wire b1 is in contact with the developing coil b2, so that when the developing member b is knitted into a net along with the knitting wire a, a stent structure as shown in fig. 4 and 5 can be formed. Further, the developing coil b2 may also cover only a part of the knitting yarn b1. For example, a plurality of developing coils b2 are wound on the knitting yarn b1, and along the axial direction of the knitting yarn b1, the developing coils b2 are arranged at equal intervals or at equal proportional intervals to meet different developing requirements, which is not specifically limited in this embodiment. Preferably, the developing coil b2 is made of one or a plurality of materials selected from platinum-tungsten alloy, platinum-iridium alloy, pure platinum, gold and tantalum wire. In summary, the developing member b provided by the present embodiment is woven in the stent, which can meet the requirement for obtaining key information such as stent shape, position, state, etc. in the operation. And, the developing coil b2 is tightly wound on the braided wire b1, so that the developing stability of the bracket can be improved, a better developing effect is ensured, and the expansion recovery performance of the bracket is favorably ensured.

Referring to fig. 1-2 and 6, the proximal end 101 is connected to the fixing member 20, at least a portion of the stent body 10 is constrained in the fixing member 20, and the fixing member 20 approaches toward the middle section 102 of the stent body 10, such that the proximal end 101 is recessed relative to the middle section 102. It can be understood that the proximal end 101 of the stent body 10 is folded in the fixing member 20, so that the proximal end 101 is in a closed state, which not only can prevent the bare end of the braided wire located at the proximal end 101 from puncturing the aneurysm cavity wall and the blood vessel wall of the aneurysm 30, but also is beneficial for the proximal end 101 to generate endothelialization, and thus, the blood flow guiding effect and the blocking effect are realized. In this embodiment, the number of the fixing members 20 is not limited, and all the bare ends of the proximal end 101 can be folded by one fixing member 20; it is also possible to split two or three of the securing members 20 to collapse the entire bare end of the proximal end 101. Further, the present embodiment does not specifically limit the shape of the distal end 103 of the stent body 10. Alternatively, as shown in fig. 1-2, the distal end 103 may also be folded in at least one of the fasteners 20; alternatively, as shown in fig. 6, the distal end 103 is free and open.

With continued reference to the first stent shown in fig. 1-2, the proximal end 101 and the distal end 103 are collapsed into the corresponding securing members 20 to avoid the bare ends from puncturing the lumen of the aneurysm 30. The proximal end 101 and the distal end 103 may respectively correspond to one fixing member 20, or two or more fixing members 20 may be correspondingly disposed. The corresponding fixing member 20 approaches toward the middle section 102, so that the proximal end 101 and the distal end 103 are recessed relative to the middle section 101, and then in the aneurysm cavity of the aneurysm 30, the middle section 102 is expanded to be able to fit the cavity wall of the aneurysm, and the proximal end 101 and the distal end 103 are recessed and do not contact with the cavity wall of the aneurysm. The distal end 103 is folded in the fixing member 20 and is recessed toward the middle section 102, so that the distal end 103 can be prevented from impacting the tumor cavity. Collapsing the proximal end 101 within the fixation element 20 and recessing toward the intermediate section 102 can provide good blood flow guidance and occlusion.

With continued reference to the second stent shown in fig. 6, the proximal end 101 is folded in at least one fastener 20, and the distal end 103 is open, and adheres to the aneurysm 30 wall along with the middle section 102, so as to ensure radial support and anchoring of the stent. Preferably, the braided wires a at the free ends of the distal ends 103 are all circular. That is, the knitting of each knitting wire a is reversed toward the intermediate section 102 after being folded to the edge of the distal end 103, so that the tip of the knitting wire a of the distal end 103 is prevented from pricking the cavity wall of the tumor.

Further, the fixing member 20 is made of a thin metal-walled member, including but not limited to a circular ring, a circular cap, and a spiral pipe. The fixing member 20 is fixedly connected to the proximal end 101 and the distal end 103, so as to restrain free ends of the proximal end 101 and the distal end 103 and avoid collapse of the braided wire a due to a radial force generated by the increase of the metal coverage. Wherein, the connection mode includes but is not limited to medical glue bonding, riveting, ion welding or laser welding and the like. Preferably, the material of the fixing member 20 includes a developing material to perform a positioning function.

Because the aneurysm 30 has a different shape, a heat treatment setting may be used to better conform to the wall of the aneurysm cavity so that the stent has a different shape in the expanded state. Specifically, in the expanded state of the stent, the proximal end 101 and the distal end 103 are recessed into the middle section 102, and the middle section 102 is expanded to fit the inner wall of the aneurysm 30, so that the outer contour of the middle section 102 includes, but is not limited to, an arch or a cylinder. Such as the first stent shown in fig. 1-2, the middle section 102 of the first stent is cylindrical. Alternatively, in the second stent shown in fig. 6 and the third stent shown in fig. 7 to 8, the corresponding middle section 102 is non-spherical. Alternatively, as shown in the fourth bracket of fig. 9, the middle section 102 is arched. Of course, the stent provided by the embodiment is not limited to the above shape, and may also be in a semicircular shape or a semi-elliptical shape. It will be appreciated that the outer profile of the intermediate section 102 is rounded, without bulges or sharp corners, so that the aneurysm 30 is not damaged by concentrated stresses.

Based on the same inventive concept, the present embodiment also provides an embolization device. The embolism device includes the transfer bar and the support, the support with the transfer bar is through the separation silk connection. After the stent is conveyed to the corresponding lesion position, the stent is separated from the conveying rod through the release wire, so that the stent can be released to the lesion position.

Based on the same inventive concept, the embodiment also provides an interventional system. The interventional system comprises a microcatheter, a micro guide wire and the embolism device, wherein the microcatheter and the micro guide wire are used for conveying the embolism device. Specifically, before the aneurysm 30 is blocked by the stent, contrast is first performed to clarify the position, size, neck range, and distribution of branch vessels of the aneurysm 30, and a stent having an appropriate shape and an appropriate specification is selected. Then, the stent is connected with the delivery rod through the release wire to constitute the embolization device, and the embolization device is installed in the interventional system. During operation, the micro guide wire is firstly placed near the position of the corresponding vascular lesion, then the micro catheter reaches the corresponding lesion along the micro guide wire, and then the micro guide wire is taken out. Finally, the embolic device is placed into and through the microcatheter lumen, pushing the stent to the lesion site. And after the release of the stent is completed, the release wire is disconnected, so that the stent is separated from the conveying rod, and the release of the stent is realized.

In summary, the present embodiments provide a stent, an embolization device and an interventional system. The stent is used for sealing aneurysm, and comprises a stent body 10 and a plurality of fixing pieces 20, wherein the proximal end 101 of the stent body 10 is folded into the corresponding fixing piece 20, so that the aneurysm cavity is prevented from being punctured by the naked end of the stent. At the same time, the fastener 20 is moved closer to the middle section 102, so that the proximal end 101 is recessed relative to the middle section 102. Further, the distal end 103 of the stent body 10 may also be bound in the fixing member 20, so that the proximal end 101 and the distal end 103 are recessed and do not contact with the tumor cavity wall, thereby avoiding the impact of the distal end 103 on the tumor cavity. Moreover, the stent body 10 is formed by weaving a plurality of weaving wires, and at least part of the weaving wires a are woven to the proximal end 101 and the distal end 103 and then reversely woven, and extend to the middle section 102, so as to increase the metal coverage of the proximal end 101 and the distal end 103, so that the proximal end 101 can better exert the blood flow guiding effect and the blocking effect, accelerate the generation of endothelialization of the proximal end 101, and be beneficial to improving the aneurysm treatment effect; and, the support force of the distal end 103 is enhanced, improving the stability of the stent. Meanwhile, the middle section 102 has a certain radial supporting force, the metal coverage rate is low, and the porosity is high, so that the flexibility and the adherence of the stent can be guaranteed, and the middle section is attached to the cavity wall of the aneurysm 30 in the expansion state. Therefore, the stent, the embolization device and the interventional system provided by the embodiment not only can relieve the influence on the parent artery, but also can improve the treatment effect of the aneurysm.

It should be understood, however, that the intention is not to limit the invention to the particular embodiments described. It will be apparent to those skilled in the art from this disclosure that many changes and modifications can be made, or equivalents modified, in the embodiments of the invention without departing from the scope of the invention. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention will still fall within the protection scope of the technical solution of the present invention.

Claims (16)

1. A bracket is characterized by comprising a bracket body and a plurality of fixing pieces; the proximal end of the stent body is connected with at least one fixing piece, at least part of the stent body is bound in the fixing piece, and the fixing piece is close to the middle section of the stent body so that the proximal end is sunken relative to the middle section;

the stent body is formed by weaving a plurality of weaving wires, and at least part of the weaving wires are reversely woven after being woven to the near end and the far end of the stent body and extend to the middle section.

2. The stent of claim 1, wherein when the number of the fasteners is greater than or equal to 2, the distal end is engaged with and constrained in at least one of the fasteners, and the fasteners are closer to a middle section of the stent body so that the distal end is recessed relative to the middle section.

3. The stent of claim 2, wherein the proximal and distal ends are connected to the anchor by means comprising: welding or medical glue bonding.

4. The stent of claim 1, wherein the proximal end and the distal end have a porosity less than a porosity of the intermediate section.

5. The stent of claim 1, wherein the opposite ends of the middle section are covered with the reverse weave in a range of 1/4 to 1/3 of the outer surface of the middle section, respectively.

6. The stent of claim 1, wherein at least some of the braided filaments are braided back and forth between the proximal end and the intermediate segment, and between the distal end and the intermediate segment.

7. The stent of claim 1, wherein the braided filaments are 48 to 288 strands.

8. The stent of claim 1, wherein the stent body is a self-expanding braided stent having an expanded state and a compressed state; and in the expanded state, the outer profile of the intermediate section is arcuate or cylindrical.

9. The stent of claim 8, wherein a maximum diameter of the stent body in the expanded state ranges from 3mm to 16mm.

10. A stent according to claim 8 wherein in the expanded state the intermediate section conforms to the wall of the tumour cavity and the proximal end faces the blood vessel to occlude the ostium of the tumour cavity.

11. The stent of claim 1, wherein the stent body comprises a visualization member woven into a mesh with the woven wire.

12. The holder of claim 11, wherein the development member comprises the woven wire and a development coil; the developing coil is wound on the weaving wire and covers at least part of the weaving wire.

13. The cradle of claim 12, wherein the developing coil material comprises one or more of platinum-tungsten alloy, platinum-iridium alloy, pure platinum, gold, and tantalum wire.

14. The bracket of claim 1, wherein the securing member comprises: the ring, the dome and the spiral pipe fitting, just the material of mounting includes development material.

15. An embolization device comprising a delivery rod and a stent according to any one of claims 1 to 14, the stent being connected to the delivery rod by a release wire.

16. An interventional system comprising a microcatheter, and the embolic device of claim 15, the microcatheter and the microcatheter for delivery of the embolic device.

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