CN115872339A - Succinyl gelatin injection production line perfusion system and technology - Google Patents
Succinyl gelatin injection production line perfusion system and technology Download PDFInfo
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- CN115872339A CN115872339A CN202310019143.6A CN202310019143A CN115872339A CN 115872339 A CN115872339 A CN 115872339A CN 202310019143 A CN202310019143 A CN 202310019143A CN 115872339 A CN115872339 A CN 115872339A
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Abstract
The invention relates to the technical field of perfusion equipment, in particular to a succinyl gelatin injection production line perfusion system and a perfusion process thereof; by designing a new filling unit, the filling bin is driven to rotate by the rotating device, when the filling bin rotates to the discharge port, the discharge plug moves inwards due to extrusion of the filling bin, and when the sensing piece at the top of the discharge plug is contacted with the sensing piece at the discharge port, the succinyl gelatin injection liquid flows into the discharge plug from the discharge port; therefore, the bottles can be filled while being moved, so that the whole filling work can be regarded as a continuous process, the filling efficiency can be increased, and unnecessary waste caused by the fact that the succinylated gelatin injection is scattered by vibration is prevented.
Description
Technical Field
The invention relates to the technical field of filling equipment, in particular to a filling system of a succinyl gelatin injection production line and a filling process thereof.
Background
The succinyl gelatin injection is a western medicine and can be mainly used for blood dilution in clinic; extracorporeal circulation or hypotension symptoms possibly occurring after spinal cord or epidural anesthesia have certain prevention effect; succinylated gelatin injection is mainly prepared from components such as succinylated gelatin, and generally is a clear light yellow liquid, slightly viscous and sometimes slightly opalescent.
The succinylated gelatin injection is a colloidal plasma substitute, and can increase the plasma volume, increase the venous return, arterial blood pressure and peripheral perfusion, and the produced osmotic diuresis function is helpful for maintaining the renal function of shock patients. The combined effect of succinylated gelatin injection helps to improve oxygen supply to the tissues: the relative viscosity of the succinylated gelatin injection is similar to that of blood plasma, and the generated blood dilution effect reduces the relative viscosity of blood, improves circulation, increases cardiac output and accelerates blood flow rate. The input of succinylated gelatin injection can reduce the hematocrit and influence the oxygen supply capacity of blood. However, as blood viscosity is reduced and microcirculation is improved, cardiac load is reduced, cardiac output is increased, and oxygen consumption of cardiac muscle is not increased. Thus, the overall effect of infusion of succinylated gelatin injection is increased oxygen transport (e.g., hematocrit of no less than 25%, not less than 30% for the elderly). The oncotic pressure of succinylated gelatin injections is used to prevent and reduce tissue edema, which tends to limit the oxygen utilization of the tissue. When peripheral tissues are anoxic, the release of hemoglobin to oxygen is increased, which is beneficial to supplying oxygen to the tissues.
In the prior art, an automatic filling machine is mostly adopted for filling, the automatic filling machine is suitable for procedures of tincture with small dose, sugar filling and cap rolling in a pharmaceutical factory, the whole machine can finish procedures of bottle arrangement, bottle conveying, quantitative filling, cap arrangement, cap conveying and cap rolling, all parts in contact with medicines are made of 316L stainless steel or PTFE, and the machine has the functions of bottle-free non-filling, variable frequency speed regulation and the like; meanwhile, the automatic filling machine adopts automatic bottle feeding and automatic filling, has high filling precision, can randomly adjust the filling quantity and the bottle size according to bottles with different specifications, and can be matched with an automatic assembly line; the product is simpler and more convenient in the aspects of use operation, precision error, installation adjustment, equipment cleaning, maintenance and the like.
However, because different filling materials are filled, different filling equipment is required, and therefore more and more manufacturers invent different automatic filling systems; for example: the chutian scientific and technological limited company provides a filling method of a liquid medicine filling device (application number: CN202010779570.0 published: 2022-02-18), the device comprises a front weighing station, a filling station, a rear weighing station, a liquid separation container and a movable filling needle frame, the bottom of the liquid separation container is obliquely arranged and is provided with a plurality of liquid outlets along the length direction, the filling needle frame is provided with a plurality of filling needles which are arranged side by side, each liquid outlet is respectively connected with each filling needle through a hose, each hose is provided with a filling pump, and the filling method comprises the following steps: the front weighing station carries out front weighing on the empty bottle; each filling needle is moved to the position above the rear weighing station; quantitatively filling the medicine bottles on a post-weighing station, and weighing and replenishing liquid to enable the medicine amount in each medicine bottle to reach the standard; and weighing at a post-weighing station, filling one by one or synchronously, and filling the medicine bottles with unqualified filling amount with the medicine liquid by a low-level filling needle. The filling method has the advantages of improving the production efficiency, reducing the waste amount of the liquid medicine and the like.
The atomic high-tech company of limited invented a high-precision automatic dispensing equipment for radioactive liquid medicine (application number: CN201710739281.6 published: 2022-09-23), which comprises: a filling and plugging system, a subpackaging system and a control system; the split charging equipment is arranged between the penicillin bottle sample introduction column and the penicillin bottle sample discharge column and is positioned on the station conveying device; conveying the penicillin bottle row seat and the penicillin bottles placed in the penicillin bottle row seat to a penicillin bottle outlet column along a straight line from an inlet station positioned on the penicillin bottle inlet column by using a station conveying device; the equipment has the characteristics of radiation resistance, high micro-packaging precision, high packaging speed, high automation degree and the like, and provides a technical basis for packaging various radioactive liquid medicines.
The filling process of a general large infusion bottle comprises the steps of firstly conveying a bottle to be filled to a bottle washing machine through a bottle supplying machine to preliminarily clean the bottle, then conveying the bottle to a tunnel type sterilization oven for high-temperature sterilization, conveying the bottle to a filling station for filling after the bottle is sterilized, conveying the bottle to a capping station and a labeling station for capping and labeling after the filling is finished, and particularly carrying out the whole process, particularly the process after the sterilization, in an aseptic environment.
However, in the prior art, linear filling or carousel filling is mostly adopted, but the above filling is performed periodically, that is, when a group or a group of bottles moves to a filling station, the bottles can be filled only after staying for a period of time, so that the filling period is prolonged, and the working efficiency is affected; moreover, as the periodic filling is adopted in the filling process, the bottle can move periodically, and the bottle can vibrate in the moving process, so that the liquid medicine is sprayed out;
therefore, the invention provides a succinyl gelatin injection production line perfusion system, which can improve the problems.
Disclosure of Invention
The technical problems to be solved by the invention are as follows: the succinyl gelatin injection production line filling system is provided, and the problem of low filling efficiency caused by periodic filling in the prior art is solved by designing a new filling unit; and the filling speed of the filling unit is not required to be slowed down, so that the filling efficiency is improved.
The invention provides the following technical scheme: the succinyl gelatin injection production line perfusion system comprises a bracket, a control unit, a perfusion unit, a conveying unit, a labeling unit and a capping unit, wherein the bracket is fixedly arranged on the ground and is used for providing support for the whole perfusion system; the bracket is fixedly provided with a control unit, and the control unit is used for controlling the whole perfusion system; the perfusion unit is fixedly arranged on the bracket and is used for perfusing succinyl gelatin injection; the conveying unit is fixedly arranged on the ground and is used for filling the succinyl gelatin injection into the bottle in cooperation with the filling unit; the labeling units are fixedly arranged on two sides of the conveying unit and used for labeling labels on bottles; the capping unit is fixedly arranged on the conveying unit and is used for sealing the bottles;
preferably, the filling unit comprises a liquid storage tank, a rotating device, a filling bin, a discharge hole, a first electromagnetic valve, a spring, a discharge plug and an induction sheet; the liquid storage tank is fixedly arranged on the bracket and used for storing succinyl gelatin injection; rotating devices are fixedly arranged on two sides of the liquid storage box, are symmetrically arranged about the liquid storage box, and are used for driving the filling bin to rotate; a filling bin is arranged in the rotating device in a sliding manner and is used for filling the succinyl gelatin injection into the bottle; the bottom of the liquid storage tank is provided with a discharge port, and the discharge port is used for adding the succinyl gelatin injection into the filling bin; a first electromagnetic valve is fixedly arranged in the discharge port and used for controlling the opening and closing of the water outlet; one ends of springs are symmetrically and fixedly arranged on two sides of the discharge hole, and the springs are used for resetting the discharge plug; the other end of the spring is fixedly provided with a discharge plug, and the discharge plug is used for being matched with the filling bin to add the succinyl gelatin injection into the filling bin; the top of the discharging plug and the discharging port are fixedly provided with induction sheets, and the induction sheets are used for inducing the position relation between the discharging plug and the discharging port;
after the succinyl gelatin injection is injected into the liquid storage tank by a worker, the control unit drives the rotating device to rotate, the rotating device drives the filling bin to rotate, when the filling bin rotates to the discharge port, the discharge plug moves inwards due to extrusion of the filling bin, when an induction sheet at the top of the discharge plug is in contact with an induction sheet at the discharge port, the control unit controls the electromagnetic valve to be opened, at the moment, the succinyl gelatin injection flows into the discharge plug from the discharge port, and when the filling bin is discharged from the discharge port, the control unit controls the electromagnetic valve to be closed; at the moment, the mobile unit just moves the bottle to the position right below the filling bin, the rotating speed of the rotating device is consistent with the moving speed of the mobile unit, and the filling bin fills the succinyl gelatin injection into the bottle in the process that the bottle and the filling bin are started together;
preferably, the bottom of the filling bin is set to be conical, so that succinyl gelatin injection in the filling bin can be completely filled into a bottle.
Preferably, a groove is formed in the rotating device and used for mounting the rotating gear and the rotating chain; a rotating chain is fixedly arranged in the groove and used for rotating to drive the filling bin to rotate; the rotating chain is fixedly connected with the filling bin, a rotating gear is fixedly installed in the rotating device and meshed with the rotating chain, and the rotating gear is used for driving the rotating chain to rotate;
the control unit controls the rotating motor to drive the rotating gear to rotate, the rotating gear rotates to drive the rotating chain to rotate, and the rotating chain drives the filling bin to rotate;
adopt rack and pinion meshing to rotate and compare in traditional belt drive, have higher stability to can prevent the filling storehouse shake at the in-process that removes the pipe, thereby avoided succinyl gelatin injection to spill from the filling storehouse.
Preferably, the conveying unit comprises a conveying frame, a conveying belt and a fixing plate, the conveying frame is fixedly arranged on the ground, and the conveying frame is used for providing support for each transmission unit; the conveying belt is arranged on the conveying frame in a sliding manner and is used for driving the bottles to move; the transmission belt is fixedly provided with a fixing plate, and the fixing plate is used for supporting the bottle; the conveying belt is provided with through holes which correspond to the bottle openings one by one, and the through holes are used for fixing the bottles in the conveying unit;
the control unit drives the conveyor belt to rotate through the conveying motor, the conveyor belt rotates to drive the bottles to rotate, the rotating conveyor belt is used for fixing the bottle openings, the bottles can be guaranteed to be stable in the moving process and move forwards at the same speed with the filling bin all the time, and therefore the filling effect is guaranteed.
Preferably, ejection of compact stopper is cylindrical, and the fillet has been seted up on the top, sets up ejection of compact stopper to cylindrical so that slide from top to bottom at the discharge gate for the convenience, has seted up the fillet on the top simultaneously so that the filling bin can be better when extrusion ejection of compact stopper is the upward motion of ejection of compact stopper for the convenience.
Preferably, the labeling unit comprises a labeling frame, a first rotating cylinder, a second rotating cylinder, a baffle and a pressing brush, the labeling frame is symmetrically arranged on two sides of the conveying frame, and the labeling frame is used for supporting the labeling unit; a first rotary drum is rotatably arranged on the labeling frame; the first rotary drum is used for rotating so that the labeling cloth slides out of the first rotary drum; a second rotary drum is rotatably arranged on the labeling rack and used for driving labeling cloth to be wound on the second rotary drum in a rotating mode; the conveying frame is fixedly provided with a baffle plate, and the baffle plate is used for separating the labeling cloth from the label; a compaction brush is arranged right in front of the baffle, the compaction brush is rotatably arranged on the conveying frame, and the compaction brush is used for compacting the label on the bottle;
adopt the cylinder to paste among the prior art usually and mark, this kind of mode is applicable to the plane generally and pastes the mark, and when pasting the mark on the cylinder, leads to the label to drop easily to lead to pasting the mark effect not good, and adopt above-mentioned mark unit of pasting to paste the label on cylindrical bottle under the effect that compresses tightly the brush, owing to adopt a pivot and No. two pivot mode of mutually supporting, the production efficiency of improvement simultaneously.
Preferably, the capping unit comprises a capping frame, a pressing head and a capping barrel, the capping frame is fixedly mounted on the conveying frame, and the capping frame is used for providing support for the capping unit; the pressing head is fixedly arranged on the cap sealing frame and is used for pressing the cap in the cap storage barrel into the bottleneck; the cap storage cylinder is fixedly arranged on the cap sealing frame and is used for storing the bottle caps;
after labeling is completed, no bottle is transported to the capping unit, when the bottle mouth of the bottle is transported to the bottom of the capping unit, the bottle cap in the capping cylinder is pressed into the bottle mouth by the pressing head in the capping unit, and at the moment, the succinyl gelatin injection is transported to the production line.
Preferably, a hollow telescopic rod is fixedly installed at the bottom end of the filling bin, an infrared sensing device is fixedly installed at the joint of the filling bin and the hollow telescopic rod, and the hollow telescopic rod is used for extending into a bottle mouth to carry out filling, so that air in the bottle can be squeezed out, and the liquid medicine is prevented from being oxidized; infrared induction device is used for responding to whether bottle aligns with the filling storehouse, and when infrared induction device sensed the bottle, the hollow telescopic link of the control unit control stretched out, stopped when the hollow telescopic link stretched out to the bottle bottom, started the filling this moment.
A filling process of a succinyl gelatin injection production line comprises the following steps:
s1: adding water for injection into gelatin by a worker to swell the gelatin, heating the gelatin to be dissolved after swelling, adding sodium hydroxide into the gelatin solution to crack the gelatin solution, adding hydrochloric acid to neutralize the gelatin solution, adding succinic anhydride into the gelatin solution to acidify the gelatin solution, adding sodium hydroxide or hydrochloric acid to adjust the pH value, filling the solution into a sealed container, adding active carbon, heating the solution to 120 ℃ for 20 minutes, taking out the solution, and filtering the active carbon to obtain succinylated gelatin solution;
s2: adding the prepared succinyl gelatin injection into a liquid storage tank for filling;
s3: after the whole liquid storage tank is filled with the succinyl gelatin injection, the control unit controls the rotating device to start, the started rotating device drives the filling bin to rotate, when the filling bin passes through the discharge port, the movable filling bin can extrude the discharge plug inwards, at the moment, the top of the discharge plug is contacted with the sensing piece at the top of the discharge port, the first electromagnetic valve is opened, and the succinyl gelatin injection flows into the filling bin;
s4: when the filling bin moves, the conveying unit drives the bottles to be filled to move, the bottles to be filled correspond to the filling bin one by one, when the filling bin moves to a discharge port, the hollow telescopic rods on the filling bin stretch out to the interior of the bottles, the hollow telescopic rods on the filling bin are in contact with a chamber at the bottom of the bottles, and at the moment, the electromagnetic valve II on the filling bin is opened, so that the succinyl gelatin injection is filled into the bottles;
s5: after filling, the bottle is transported to a capping unit, and when the bottle mouth of the bottle is transported to the bottom of the capping unit, a pressing head in the capping unit presses the bottle cap in the capping cylinder into the bottle mouth;
s6: after the sealing is finished, the conveying unit drives the succinyl gelatin injection to enter a water bath sterilization cabinet for sterilization, and the sterilized succinyl gelatin injection moves forwards continuously along with the conveying unit;
s7: after water bath sterilization, the second rotary drum in the labeling unit rotates to drive the labeling cloth to move, the moving labeling cloth drives the first rotary drum to rotate, in the circulating process, due to the blocking of the baffle, the label on the labeling cloth can be separated from the labeling cloth, at the moment, the conveying unit drives the bottle to move to the label position, the label can be automatically attached to the bottle, and the label is pressed by the pressing brush, at the moment, labeling is completed; the conveying unit drives the succinyl gelatin injection and transports the succinyl gelatin injection to the production line.
The invention has the following beneficial effects:
1. according to the invention, a new filling unit is designed, the filling bin is driven to rotate by the rotating device, when the filling bin rotates to the discharge port, the discharge plug moves inwards due to the extrusion of the filling bin, and when the sensing piece at the top of the discharge plug is contacted with the sensing piece at the discharge port, succinyl gelatin injection liquid flows into the discharge plug from the discharge port; and can move the bottle and carry out the filling to the bottle simultaneously, make whole filling work regard as a continuous process, can increase the efficiency of filling, also prevented simultaneously that the vibration from spilling succinyl gelatin injection, causing unnecessary waste.
2. According to the invention, a new sealing unit is designed, a second rotating shaft in a labeling unit rotates to drive a second rotating drum to rotate, the second rotating drum rotates to drive labeling cloth to move, the moving labeling cloth drives a first rotating shaft and a first rotating drum to rotate, and in the circulating process, a label on the labeling cloth can be separated from the labeling cloth due to the blocking of a baffle plate, and at the moment, a conveying unit drives a bottle to move to the label position, so that the label can be automatically attached to the bottle; can paste the label on cylindrical bottle under the effect that compresses tightly the brush, simultaneously owing to adopt a pivot and No. two pivot mode of mutually supporting, can also paste the mark in the canning, the production efficiency of improvement.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is an overall schematic view of the present invention;
FIG. 2 is a schematic view of a filling unit of the present invention;
FIG. 3 is a schematic view of the position of the discharge plug of the present invention;
FIG. 4 is a schematic view of the shape of the discharge plug of the present invention;
FIG. 5 is a schematic view of a discharge port of the present invention;
FIG. 6 is a schematic view of the shape of the filler bin of the present invention;
FIG. 7 is a schematic view of the sprocket chain of the present invention;
FIG. 8 is a schematic view of a transfer unit of the present invention;
FIG. 9 is a schematic view of a labeling unit of the present invention;
FIG. 10 is a schematic view of a capping unit of the present invention;
FIG. 11 is a schematic view of the hollow telescopic shaft of the present invention;
FIG. 12 is a process flow diagram of the present invention.
In the figure: 1. a support; 2. a control unit; 3. a perfusion unit; 31. a liquid storage tank; 32. a rotating device; 321. rotating the chain; 322. a rotating gear; 33. filling a bin; 331. a hollow telescopic rod; 332. an infrared sensing device; 34. a discharge port; 35. a first electromagnetic valve; 36. a spring; 37. a discharging plug; 38. an induction sheet; 4. a transfer unit; 41. a transfer frame; 42. a conveyor belt; 43. a fixing plate; 5. a labeling unit; 51. label sticking frame; 52. a first rotating drum; 53. a second rotating drum; 54. a baffle plate; 55. a compaction brush; 6. a capping unit; 61. a cover sealing frame; 62. a pressing head; 63. a cover storage cylinder.
Detailed Description
In order to better understand the technical solution, the technical solution will be described in detail with reference to the drawings and the specific embodiments.
First embodiment
Fig. 1 is an overall view of a succinylated gelatin injection line perfusion system, in which the front end of the succinylated gelatin injection line perfusion system is shown on the left side of the figure and the back end of the succinylated gelatin injection line perfusion system is shown on the right side of the figure by definition.
As shown in fig. 1 to 11, the succinylated gelatin injection production line perfusion system of the present invention comprises a bracket 1, a control unit 2, a perfusion unit 3, a conveying unit 4, a labeling unit 5 and a capping unit 6, wherein the bracket 1 is fixedly installed on the ground, and the bracket 1 is used for providing support for the whole perfusion system; the bracket 1 is fixedly provided with a control unit 2, and the control unit 2 is used for controlling the whole perfusion system; the perfusion unit 3 is fixedly arranged on the bracket 1, and the perfusion unit 3 is used for perfusing succinyl gelatin injection; the conveying unit 4 is fixedly arranged on the ground, and the conveying unit 4 is used for being matched with the pouring unit 3 to pour the succinyl gelatin injection liquid into the bottle; the labeling units 5 are fixedly arranged at two sides of the conveying unit 4, and the labeling units 5 are used for labeling the bottles; the capping unit 6 is fixedly mounted on the conveying unit 4, and the capping unit 6 is used for sealing the bottles;
in the prior art, labeling and sealing are carried out after filling is finished, so that the production line is prolonged, and meanwhile, the occupied area is increased; the succinyl gelatin injection production line filling system can be adopted to label while filling; meanwhile, the filling units are continuously filled in the filling process, so that the filling efficiency is improved.
On the basis of the above embodiment 1, as shown in fig. 2 to 7, the filling unit 3 includes a liquid storage tank 31, a rotating device 32, a filling bin 33, a discharge port 34, a first electromagnetic valve 35, a spring 36, a discharge plug 37 and a sensing piece 38; the liquid storage tank 31 is fixedly arranged on the bracket 1, and the liquid storage tank 31 is used for storing succinyl gelatin injection; the two sides of the liquid storage tank 31 are fixedly provided with rotating devices 32, the rotating devices 32 are symmetrically arranged relative to the liquid storage tank 31, and the rotating devices 32 are used for driving the filling bin 33 to rotate; a filling bin 33 is arranged in the rotating device 32 in a sliding manner, and the filling bin 33 is used for filling the succinyl gelatin injection into a bottle; a discharge port 34 is formed in the bottom of the liquid storage tank 31, and the discharge port 34 is used for adding the succinyl gelatin injection into the filling bin 33; a first electromagnetic valve 35 is fixedly installed in the discharge port 34, and the first electromagnetic valve 35 is used for controlling the opening and closing of the water outlet; one ends of springs 36 are symmetrically and fixedly arranged on two sides of the discharge hole 34, and the springs 36 are used for resetting the discharge plug 37; the other end of the spring 36 is fixedly provided with a discharge plug 37, and the discharge plug 37 is used for matching with the filling bin 33 to add the succinyl gelatin injection into the filling bin 33; an induction sheet 38 is fixedly arranged on the top of the discharging plug 37 and the discharging port 34, and the induction sheet 38 is used for inducing the position relation between the discharging plug 37 and the discharging port 34;
when the succinyl gelatin injection liquid injection device works, after a worker injects succinyl gelatin injection liquid into the liquid storage tank 31, the control unit 2 drives the rotating device 32 to rotate, the rotating device 32 drives the filling bin 33 to rotate, when the filling bin 33 rotates to the position of the discharge hole 34, the discharge plug 37 moves inwards due to extrusion of the filling bin 33, when the sensing piece 38 at the top of the discharge plug 37 is in contact with the sensing piece 38 of the discharge hole 34, the control unit 2 controls the electromagnetic valve to be opened, at the moment, the succinyl gelatin injection liquid flows into the discharge plug 37 from the discharge hole 34, and when the filling bin 33 is discharged from the discharge hole 34, the control unit 2 controls the electromagnetic valve to be closed; at this time, the mobile unit moves the bottle to be right below the filling bin 33, the rotating speed of the rotating device 32 is consistent with the moving speed of the mobile unit, and the filling bin 33 fills the succinylated gelatin injection into the bottle in the process that the bottle and the filling bin 33 are started together;
by adopting the filling unit, the bottle can be filled while being moved, the whole filling work can be regarded as a continuous process, the filling efficiency can be increased, and unnecessary waste caused by the sprinkling of the succinylated gelatin injection liquid by vibration can be prevented.
On the basis of the above embodiment 1, as shown in the figure, the bottom of the filling bin 33 is set to be conical, so as to facilitate the complete filling of the succinyl gelatin injection in the filling bin 33 into the bottle, compared with the conventional rectangular filling bin 33, the filling bin 33 with the conical bottom is adopted, and due to the inclined angle, the succinyl gelatin injection can flow into the bottle from the filling bin 33 more cleanly, so that the succinyl gelatin injection residue in the filling bin 33 is avoided.
On the basis of the above embodiment 1, as shown in the figure, a groove is formed in the rotating device 32, and the groove is used for mounting the rotating gear 322 and the rotating chain 321; a rotating chain 321 is fixedly arranged in the groove, and the rotating chain 321 is used for rotating to drive the filling bin 33 to rotate; the rotating chain 321 is fixedly connected with the filling bin 33, a rotating gear 322 is fixedly installed in the rotating device 32, the rotating gear 322 is meshed with the rotating chain 321, and the rotating gear 322 is used for driving the rotating chain 321 to rotate;
during operation, the control unit 2 controls the rotating motor to drive the rotating gear 322 to rotate, the rotating gear 322 rotates to drive the rotating chain 321 to rotate, and the rotating chain 321 drives the filling bin 33 to rotate;
compared with the traditional belt transmission, the gear and rack meshing rotation has higher stability, and can prevent the filling bin 33 from shaking in the process of moving the tube, thereby preventing the succinyl gelatin injection from spilling out of the filling bin 33.
On the basis of the above embodiment 1, as shown in fig. 8, the conveying unit 4 includes a conveying frame 41, a conveying belt 42 and a fixing plate 43, the conveying frame 41 is fixedly installed on the ground, and the conveying frame 41 is used for providing support for each transmission unit; a conveyor belt 42 is slidably mounted on the conveyor frame 41, and the conveyor belt 42 is used for driving the bottles to move; a fixing plate 43 is fixedly arranged on the transmission belt, and the fixing plate 43 is used for supporting the bottle; through holes which correspond to bottle openings one by one are formed in the conveying belt 42 and used for fixing the bottles in the conveying unit 4;
the control unit 2 drives the conveying belt 42 to rotate through the conveying motor, the conveying belt 42 rotates to drive the bottles to rotate, the rotating conveying belt 42 is used for fixing the bottle openings, the bottles can be guaranteed to be stable in the moving process and move forwards at the same speed with the filling bin 33 all the time, and therefore the filling effect is guaranteed.
On the basis of the above embodiment 1, as shown in fig. 4, the discharge plug 37 is cylindrical, and the top end of the discharge plug 37 is provided with a round corner, the discharge plug 37 is cylindrical so as to slide up and down at the discharge port 34, and the round corner is provided at the top end so as to facilitate the upward movement of the discharge plug 37 when the filling bin 33 extrudes the discharge plug 37.
On the basis of the foregoing embodiment 1, as shown in fig. 9, the labeling unit 5 includes a labeling frame 51, a first rotating drum 52, a second rotating drum 53, a baffle 54 and a pressing brush 55, the labeling frame 51 is symmetrically installed on two sides of the conveying frame 41, and the labeling frame 51 is used for providing support for the labeling unit 5; a first rotating drum 52 is rotatably arranged on the label sticking frame 51; drum number one 52 is used for rotating so as to enable the labeling cloth to slide out of drum number one 52; a second rotary drum 53 is rotatably mounted on the labeling frame 51 and used for driving labeling cloth to be wound on the second rotary drum 53 in a rotating manner; the conveying frame 41 is fixedly provided with a baffle plate 54, and the baffle plate 54 is used for separating the labeling cloth from the labels; a pressing brush 55 is arranged right in front of the baffle 54, the pressing brush 55 is rotatably arranged on the conveying frame 41, and the pressing brush 55 is used for pressing a label on a bottle;
after water bath sterilization, the second rotating drum 53 in the labeling unit 5 rotates, the second rotating drum 53 rotates to drive the labeling cloth to move, the moving labeling cloth drives the first rotating drum 52 to rotate, in the circulating process, due to the blocking of the baffle 54, the labels on the labeling cloth can be separated from the labeling cloth, the conveying unit 4 drives the bottles to move to the labels, the labels can be automatically attached to the bottles, and the labels are pressed by the pressing brush 55, so that the labeling is completed; the conveying unit 4 drives the succinyl gelatin injection and transports the succinyl gelatin injection to the production line;
adopt the cylinder to paste the mark usually among the prior art, this kind of mode is applicable to the plane and pastes the mark usually, and when pasting the mark on the cylinder, leads to the label to drop easily to lead to pasting a mark effect not good, and adopt above-mentioned subsides mark unit 5 can paste the label on cylindrical bottle under the effect that compresses tightly brush 55, owing to adopt a pivot and No. two pivot mode of mutually supporting, the production efficiency who improves simultaneously.
On the basis of the above embodiment 1, as shown in fig. 10, the capping unit 6 includes a capping frame 61, a pressing head 62 and a capping cylinder 63, the capping frame 61 is fixedly mounted on the conveying frame 41, and the capping frame 61 is used for providing support for the capping unit 6; the pressing head 62 is fixedly arranged on the cap sealing frame 61, and the pressing head 62 is used for pressing the cap in the cap storage barrel 63 into the bottleneck; the cap storage cylinder 63 is fixedly arranged on the cap sealing frame 61, and the cap storage cylinder 63 is used for storing a bottle cap;
after labeling is completed, the bottle is transported to the capping unit 6, and when the mouth of the bottle is transported to the bottom of the capping unit 6, the pressing head 62 in the capping unit 6 presses the cap in the capping cylinder into the mouth, at which time the succinylated gelatin injection solution is transported out of the production line.
Second embodiment
As shown in fig. 11, fig. 11 is a second embodiment of the succinylated gelatin injection solution production line perfusion system. The construction and the installation, locking, fitting and removal of the succinylated gelatin injection line filling system of this embodiment are substantially similar to those of the succinylated gelatin injection line filling system of fig. 1 of the first embodiment, and the description thereof will not be repeated, and only the differences with respect to the first embodiment will be described. The difference lies in that a hollow telescopic rod 331 is fixedly installed at the bottom end of the filling bin 33, an infrared sensing device 332 is fixedly installed at the joint of the filling bin 33 and the hollow telescopic rod 331, and the hollow telescopic rod 331 is used for extending into a bottle mouth for filling, so that air in the bottle can be extruded out, liquid medicine is prevented from being oxidized, and meanwhile, bubbles are prevented from being generated in the filling process; the infrared sensing device 332 is used for sensing whether the bottles are aligned with the filling bin 33 or not, when the infrared sensing device 332 senses the bottles, the control unit 2 controls the hollow telescopic rod 331 to extend out, and when the hollow telescopic rod 331 extends out to the bottom of the bottles, the filling is started. This embodiment overcomes the problem of the easy generation of air bubbles when the filling cartridge 33 fills the succinylated gelatin injection into the bottle.
As shown in fig. 12, the filling process of the succinylated gelatin injection production line is as follows:
s1: adding water for injection into gelatin by a worker to swell the gelatin, heating the gelatin to be dissolved after swelling, adding sodium hydroxide into the gelatin solution to crack the gelatin solution, adding hydrochloric acid to neutralize the gelatin solution, adding succinic anhydride into the gelatin solution to acidify the gelatin solution, adding sodium hydroxide or hydrochloric acid to adjust the pH value, filling the solution into a sealed container, adding active carbon, heating the solution to 120 ℃ for 20 minutes, taking out the solution, and filtering the active carbon to obtain succinylated gelatin solution;
s2: adding the prepared succinyl gelatin injection into a liquid storage tank 31 and waiting for filling;
s3: after the whole liquid storage tank 31 is filled with the succinyl gelatin injection, the control unit 2 controls the rotating device 32 to be started, the started rotating device 32 drives the filling bin 33 to rotate, when the filling bin 33 passes through the discharge port 34, the movable filling bin 33 extrudes the discharge plug 37 inwards, the top of the discharge plug 37 is in contact with the sensing sheet 38 at the top of the discharge port 34, the first electromagnetic valve 35 is opened, and the succinyl gelatin injection flows into the filling bin 33;
s4: when the filling bin 33 moves, the conveying unit 4 drives the bottles to be filled to move, the bottles to be filled correspond to the filling bins 33 one by one, when the filling bin 33 moves to the discharge port 34, the hollow telescopic rod 331 on the filling bin 33 extends to the interior of the bottles, the hollow telescopic rod 331 on the filling bin 33 is in contact with a contact chamber at the bottom of the bottles, at the moment, the electromagnetic valve II on the filling bin 33 is opened, and the succinyl gelatin injection is filled into the bottles;
s5: after filling, the bottles are transported to the capping unit 6, and when the bottle openings of the bottles are conveyed to the bottom of the capping unit 6, the bottle caps in the capping cylinders are pressed into the bottle openings by the pressing heads 62 in the capping unit 6;
s6: after the sealing is finished, the conveying unit 4 drives the succinyl gelatin injection to enter a water bath sterilization cabinet for sterilization, and the sterilized succinyl gelatin injection moves forwards continuously along with the conveying unit 4;
s7: after water bath sterilization, the second rotary drum 53 in the labeling unit 5 rotates, the second rotary drum 53 rotates to drive the labeling cloth to move, the moving labeling cloth drives the first rotary drum 52 to rotate, in the circulating process, due to the blocking of the baffle 54, the label on the labeling cloth can be separated from the labeling cloth, the conveying unit 4 drives the bottle to move to the label, the label can be automatically attached to the bottle, and the label is pressed by the pressing brush 55, so that labeling is completed; the conveying unit 4 drives the succinyl gelatin injection solution and transports the succinyl gelatin injection solution to the production line.
When the succinyl gelatin injection filling machine works, after the whole liquid storage tank 31 is filled with succinyl gelatin injection, the control unit 2 controls the rotating device 32 to be started, the started rotating device 32 drives the filling bin 33 to rotate, when the filling bin 33 passes through the discharge port 34, the movable filling bin 33 extrudes the discharge plug 37 inwards, the top of the discharge plug 37 is in contact with the sensing piece 38 at the top of the discharge port 34, the first electromagnetic valve 35 is opened, and the succinyl gelatin injection flows into the filling bin 33;
when the filling bin 33 moves, the conveying unit 4 drives the bottles to be filled to move, the bottles to be filled correspond to the filling bins 33 one by one, when the filling bin 33 moves to the discharge port 34, the hollow telescopic rod 331 on the filling bin 33 extends to the interior of the bottles, the hollow telescopic rod 331 on the filling bin 33 is in contact with a contact chamber at the bottom of the bottles, at the moment, the electromagnetic valve II on the filling bin 33 is opened, and the succinyl gelatin injection is filled into the bottles;
when the filling unit 3 fills and moves forwards, the second rotary drum 53 in the labeling unit 5 rotates, the second rotary drum 53 rotates to drive the labeling cloth to move, the moving labeling cloth drives the first rotary drum 52 to rotate, in the circulating process, due to the blocking of the baffle 54, the label on the labeling cloth can be separated from the labeling cloth, the conveying unit 4 drives the bottle to move to the label position, the label can be automatically attached to the bottle, and the label is compressed by the compression brush 55, so that the labeling is completed;
after labeling is completed, the bottle is transported to the capping unit 6, and when the mouth of the bottle is transported to the bottom of the capping unit 6, the pressing head 62 in the capping unit 6 presses the cap in the capping cylinder into the mouth, at which time the succinylated gelatin injection solution is transported out of the production line.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. The succinyl gelatin injection production line perfusion system comprises a bracket (1), a control unit (2), a perfusion unit (3), a conveying unit (4), a labeling unit (5) and a capping unit (6), and is characterized in that the bracket (1) is fixedly arranged on the ground, and the bracket (1) is used for providing support for the whole perfusion system; the bracket (1) is fixedly provided with a control unit (2), and the control unit (2) is used for controlling the whole perfusion system; the perfusion unit (3) is fixedly arranged on the bracket (1), and the perfusion unit (3) is used for perfusing succinyl gelatin injection; the conveying unit (4) is fixedly arranged on the ground, and the conveying unit (4) is used for being matched with the filling unit (3) to fill the succinyl gelatin injection liquid into the bottle; the labeling units (5) are fixedly arranged on two sides of the conveying unit (4), and the labeling units (5) are used for labeling the bottles; the capping unit (6) is fixedly arranged on the conveying unit (4), and the capping unit (6) is used for sealing the bottle.
2. The succinylated gelatin injection production line perfusion system of claim 1, characterized in that: the filling unit (3) comprises a liquid storage tank (31), a rotating device (32), a filling bin (33), a discharge hole (34), a first electromagnetic valve (35), a spring (36), a discharge plug (37) and an induction sheet (38); the liquid storage tank (31) is fixedly arranged on the support (1), the two sides of the liquid storage tank (31) are fixedly provided with rotating devices (32), and the rotating devices (32) are symmetrically arranged relative to the liquid storage tank (31); the rotating device (32) is internally provided with a filling bin (33) in a sliding way; a discharge port (34) is formed in the bottom of the liquid storage tank (31), and a first electromagnetic valve (35) is fixedly installed in the discharge port (34); one ends of springs (36) are symmetrically and fixedly installed at two sides of the discharge hole (34), and a discharge plug (37) is fixedly installed at the other end of each spring (36); and the top of the discharging plug (37) and the discharging hole (34) are fixedly provided with induction sheets (38).
3. The succinylated gelatin injection production line perfusion system of claim 2, characterized in that: the bottom of the filling bin (33) is conical.
4. The succinylated gelatin injection liquid production line perfusion system of claim 3, characterized in that: the packaging bin is characterized in that a groove is formed in the rotating device (32), a rotating chain (321) is fixedly mounted in the groove, the rotating chain (321) is fixedly connected with the packaging bin (33), a rotating gear (322) is fixedly mounted in the rotating device (32), and the rotating gear (322) is meshed with the rotating chain (321).
5. The succinylated gelatin injection production line perfusion system of claim 4, characterized in that: conveying unit (4) are including conveying frame (41), conveyer belt (42) and soft conveying board, conveying frame (41) fixed mounting is subaerial, slidable mounting has conveyer belt (42) on conveying frame (41), fixed mounting has fixed plate (43) on conveying frame (41), set up the through-hole with bottleneck one-to-one on conveyer belt (42).
6. The succinylated gelatin injection liquid production line perfusion system of claim 5, characterized in that: the discharging plug (37) is cylindrical, and the top end of the discharging plug is provided with a round angle.
7. The succinylated gelatin injection production line perfusion system of claim 6, characterized in that: the labeling unit (5) comprises a labeling frame (51), a first rotating cylinder (52), a second rotating cylinder (53), a baffle (54) and a pressing brush (55), the labeling frame (51) is symmetrically installed on two sides of the conveying frame (41), the labeling frame (51) is rotatably installed with the first rotating cylinder (52), the labeling frame (51) is rotatably installed with the second rotating cylinder (53), the conveying frame (41) is fixedly installed with the baffle (54), the pressing brush (55) is installed right in front of the baffle (54), and the pressing brush (55) is rotatably installed on the conveying frame (41).
8. The succinylated gelatin injection production line perfusion system of claim 7, characterized in that: the capping unit (6) comprises a capping frame (61), a pressing head (62) and a capping barrel (63), the capping frame (61) is fixedly arranged on the conveying frame (41), and the pressing head (62) is fixedly arranged on the capping frame (61); the cover storage barrel (63) is fixedly arranged on the cover sealing frame (61).
9. The succinylated gelatin injection production line perfusion system of claim 8, wherein: the bottom end of the filling bin (33) is fixedly provided with a hollow telescopic rod (331), and the joint of the filling bin (33) and the hollow telescopic rod (331) is fixedly provided with an infrared sensing device (332).
10. The infusion process of the succinyl gelatin injection production line is characterized in that: a succinylated gelatin injection solution production line perfusion system comprising a process as claimed in any one of claims 1 to 9, the process comprising the steps of:
s1: adding water for injection into gelatin by a worker to swell the gelatin, heating the gelatin to be dissolved after swelling, adding sodium hydroxide into the gelatin solution to crack the gelatin solution, adding hydrochloric acid to neutralize the gelatin solution, adding succinic anhydride into the gelatin solution to acidify the gelatin solution, adding sodium hydroxide or hydrochloric acid to adjust the pH value, filling the solution into a sealed container, adding active carbon, heating the solution to 120 ℃ for 20 minutes, taking out the solution, and filtering the active carbon to obtain succinylated gelatin solution;
s2: adding the prepared succinyl gelatin injection into a liquid storage tank (31) for filling;
s3: after the succinyl gelatin injection fills the whole liquid storage tank (31), the control unit (2) controls the rotating device (32) to start, the rotating device (32) after starting drives the filling bin (33) to rotate, when the filling bin (33) passes through the discharge hole (34), the movable filling bin (33) extrudes the discharge plug (37) inwards, at the moment, the top of the discharge plug (37) is contacted with the sensing sheet (38) at the top of the discharge hole (34), the first electromagnetic valve (35) is opened, and the succinyl gelatin injection flows into the filling bin (33);
s4: when the filling bin (33) moves, the conveying unit (4) drives the bottles to be filled to move, the bottles to be filled correspond to the filling bin (33) one by one, when the filling bin (33) moves to the discharge port (34), the hollow telescopic rod (331) on the filling bin (33) extends to the interior of the bottles, the hollow telescopic rod (331) on the filling bin (33) is in contact with a chamber at the bottom of the bottles, at the moment, the electromagnetic valve II on the filling bin (33) is opened, and the succinyl gelatin injection is filled into the bottles;
s5: when the filling unit (3) is filled and moves forwards, the second rotary drum (53) in the labeling unit (5) rotates, the second rotary drum (53) rotates to drive the labeling cloth to move, the moving labeling cloth drives the first rotary drum (52) to rotate, in the circulating process, due to the blocking of the baffle (54), the label on the labeling cloth can be separated from the labeling cloth, at the moment, the conveying unit (4) drives the bottle to move to the label position, the label can be automatically attached to the bottle and is pressed by the pressing brush (55), and at the moment, labeling is finished;
s6: after labeling is completed, the bottle is transported to a capping unit (6), and when the bottle mouth of the bottle is transported to the bottom of the capping unit (6), a pressing head (62) in the capping unit (6) presses the bottle cap in a capping cylinder into the bottle mouth, and at the moment, the succinyl gelatin injection liquid is transported to the production line.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202310019143.6A CN115872339B (en) | 2023-01-06 | 2023-01-06 | Succinyl gelatin injection production line filling system and filling process thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202310019143.6A CN115872339B (en) | 2023-01-06 | 2023-01-06 | Succinyl gelatin injection production line filling system and filling process thereof |
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| CN115872339B CN115872339B (en) | 2023-07-28 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3797537A (en) * | 1972-01-10 | 1974-03-19 | Sybron Corp | No-can no-fill feeding star wheel |
| JPS4957988A (en) * | 1972-07-17 | 1974-06-05 | ||
| CN101734595A (en) * | 2009-12-25 | 2010-06-16 | 广州市万世德包装机械有限公司 | Filling valve and process for filling materials using same |
| CN103449348A (en) * | 2013-09-12 | 2013-12-18 | 成都硅宝科技股份有限公司 | Automatic packaging machine for packaging viscous fluids |
-
2023
- 2023-01-06 CN CN202310019143.6A patent/CN115872339B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3797537A (en) * | 1972-01-10 | 1974-03-19 | Sybron Corp | No-can no-fill feeding star wheel |
| JPS4957988A (en) * | 1972-07-17 | 1974-06-05 | ||
| CN101734595A (en) * | 2009-12-25 | 2010-06-16 | 广州市万世德包装机械有限公司 | Filling valve and process for filling materials using same |
| CN103449348A (en) * | 2013-09-12 | 2013-12-18 | 成都硅宝科技股份有限公司 | Automatic packaging machine for packaging viscous fluids |
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| CN115872339B (en) | 2023-07-28 |
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