CN115856139A - Microfluidic multi-channel synchronous detection system for food safety rapid analysis - Google Patents
Microfluidic multi-channel synchronous detection system for food safety rapid analysis Download PDFInfo
- Publication number
- CN115856139A CN115856139A CN202211607399.0A CN202211607399A CN115856139A CN 115856139 A CN115856139 A CN 115856139A CN 202211607399 A CN202211607399 A CN 202211607399A CN 115856139 A CN115856139 A CN 115856139A
- Authority
- CN
- China
- Prior art keywords
- sample
- food safety
- channel
- communicated
- current
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Abstract
The invention discloses a microfluidic multichannel synchronous detection system for food safety rapid analysis, which comprises: the peristaltic pump is communicated with the input end of the eight-way valve and is used for quantitatively transmitting the sample to be processed to the eight-way valve; the injection pump is communicated with the input end of the eight-way valve and is used for quantitatively transmitting the current to the eight-way valve; the micro-fluidic chip is communicated with the output end of the eight-way valve and is used for mixing a sample to be processed with a carrier and enriching heavy metals or rare earth elements of the sample to be detected to form the sample to be detected; the micro atomizer is communicated with the output end of the microfluidic chip and is used for obtaining a sample to be detected and simultaneously injecting the sample to be detected into a food safety risk substance analysis instrument for detection; the data acquisition device is in data interaction with the food safety risk substance analysis instrument and is used for acquiring a detection result and generating a detection report; compared with the conventional one-by-one detection, the method shortens the detection time, improves the detection efficiency, has the characteristic of high flux, and can detect multiple indexes simultaneously.
Description
Technical Field
The invention relates to the technical field of food safety detection, in particular to a microfluidic multi-channel synchronous detection system for food safety rapid analysis.
Background
At present, food and agricultural product safety quality is more and more strictly supervised, sampling frequency is higher and higher, a plurality of food safety rapid analysis instruments are put into use in the market, but the applied technical means mainly include methods such as spectrophotometry, enzyme inhibition, colloidal gold and the like, a large amount of time is needed for sample pretreatment, and a detected result has certain errors and can only be used as a reference for risk control. At present, the rapid detection project mainly detects organic phosphorus, carbamates, clenbuterol, chloromycetin, malachite green, nitrofuran metabolites, common food additives, illegal additives and the like, and for monitoring carcinogenic substances such as organic substances (such as benzopyrene and bisphenol A) and rare earth elements, the substances are often ignored due to the lack of a rapid and effective detection method, and in fact, the substances cause great harm to the health of human beings and the immunologic function of organisms.
At present, conventional instrument analysis methods for dangerous substances in food safety mainly comprise LC/MS, GC/MS, LC-MS/MS and the like, although results are relatively accurate, the pretreatment process is relatively complex, the instrument equipment investment and maintenance cost is high, the requirement on the operation level of detection personnel is high, the detection and analysis time is 2-6 hours, an analysis report usually needs 3-20 days to be taken, most of foods, especially edible agricultural products, flow into the market before the detection result comes out, and even are eaten by consumers. Therefore, it is urgently needed to develop a novel, rapid and effective technology for detecting such substances, and to perform high-throughput and high-sensitivity hazard identification and novel hazard-related detection on the food safety hazardous substances.
Disclosure of Invention
In order to solve the problems, the invention aims to design a microfluidic multichannel synchronous detection system for food safety and rapid analysis, a microfluidic chip technology is adopted for preprocessing a sample to be detected, a plurality of analysis instruments at the rear section are combined for detecting rare earth elements and organic pollutants in food, the combined use of the rare earth elements and the organic pollutants integrates the advantages of the rare earth elements and the organic pollutants, and the total metal amount and the morphological analysis of a trace sample can be realized.
In order to achieve the above technical object, the present application provides a microfluidic multi-channel synchronous detection system for rapid analysis of food safety, comprising:
the peristaltic pump is communicated with the input end of the eight-way valve and is used for quantitatively transmitting the sample to be processed to the eight-way valve;
the injection pump is communicated with the input end of the eight-way valve and is used for quantitatively transmitting the carrier flow to the eight-way valve;
the micro-fluidic chip is communicated with the output end of the eight-way valve and is used for mixing a sample to be processed with a carrier and enriching heavy metals or rare earth elements of the sample to be detected to form the sample to be detected;
the micro atomizer is communicated with the output end of the microfluidic chip and is used for acquiring a sample to be detected and simultaneously injecting the sample to be detected into a food safety risk substance analysis instrument for detection;
and the data acquisition device is in data interaction with the food safety risk substance analysis instrument and is used for acquiring a detection result and generating a detection report.
Preferably, the eight-way valve is communicated with the microfluidic chip through a PTFE tube with the inner diameter of 0.25 mm; the inner diameter of the tube of the peristaltic pump was 0.19mm, and the flow rate was 50. Mu.L/min.
Preferably, the microfluidic chip comprises:
the atomizer connecting port is communicated with the micro atomizer,
the third sampling channel is used for being communicated with the atomizer connecting port,
the second sampling channel is respectively communicated with one end of the third sampling channel and one end of the fourth current-carrying channel, the other end of the fourth current-carrying channel is provided with a waste liquid outlet,
the first sampling channel is used for being respectively communicated with the second sampling channel, and is provided with a first current-carrying channel with a first current-carrying inlet, a second current-carrying channel with a second current-carrying inlet, and a third current-carrying channel with a sample inlet;
the waste liquid outlet, the first current-carrying inlet, the second current-carrying inlet and the sample inlet are respectively communicated with the output end of the eight-way valve.
Preferably, the lengths of the first sampling channel, the second sampling channel and the third sampling channel are respectively 5-30mm and adjustable, and the sample output of the micro atomizer is 40-200 muL and adjustable.
Preferably, the lengths of the second sampling channel and the third sampling channel are the same, and the length of the first sampling channel is 2-4 times of the sum of the lengths of the second sampling channel and the third sampling channel;
the first sampling channel, the second sampling channel and the third sampling channel have the same channel cross section, the upper bottom and the lower bottom of the channel cross section are respectively 60 and 140 micrometers, the depth is 40 micrometers, and the sectional area is 0.008mm 2 。
Preferably, the turning direction of the second current carrying channel faces the direction of the connecting port of the atomizer.
Preferably, the flow rate at which the micro-nebulizer is injected into the sample to be tested is greater than 4.77 μ L/min, wherein the flow rate at which the micro-nebulizer is injected into the sample to be tested is 5.25 μ L/min when the flow rate of the carrier fluid output by the syringe pump is 20 μ L/min.
Preferably, the number of the micro-atomizers is 1 or more, when the number of the micro-atomizers is more than one, each micro-atomizer is connected with a food safety risk substance analysis instrument, and different types of samples to be detected are transmitted by the aid of an injection pump according to the functions of the food safety risk substance analysis instrument; when the quantity of micro atomizer was 1, set up the transmission path with the output intercommunication of this micro atomizer, through the boosting of syringe pump, in the food safety risk substance analysis instrument of difference is transmitted to the sample that will await measuring simultaneously.
Preferably, the micro atomizer is communicated with a plurality of food safety risk substance analysis instruments and is used for synchronously obtaining a sample to be detected, detecting whether the sample to be detected contains one or more of heavy metals, rare earth elements and organic pollutants, and giving specific content.
Preferably, the data acquisition device is a mobile terminal, and the data acquisition device establishes a wireless parallel data interaction channel with various food safety risk substance analysis instruments, acquires a detection result and generates a detection report.
The invention discloses the following technical effects:
the invention integrates a plurality of steps of sample detection on a small chip by utilizing the microfluidic technology, integrates the operation steps by matching and combining the size and the curvature of a flow passage, a micro valve and a cavity design, and finally realizes the miniaturization and the automation of the whole detection integration. The micro-fluidic chip has the characteristics of controllable liquid flow, extremely less consumption of samples and reagents, ten-fold or hundred-fold improvement of analysis speed and the like, can simultaneously analyze hundreds of samples in a few minutes or even shorter time, and can realize the whole processes of pretreatment and analysis of the samples on line. The rapid analysis and detection can be carried out by connecting platforms such as GC-MS, LC-MS, ICP-MS and the like in series. The microfluidic system can be designed into a multi-channel, so that a sample to be detected can be simultaneously distributed to a plurality of reaction units through a micro-channel network, and the reaction units are isolated from each other, so that the reactions are not interfered with each other, and the detection of a plurality of items can be performed on the same sample in parallel according to the requirement. Compared with the conventional one-by-one item detection, the method greatly shortens the detection time, improves the detection efficiency, has the characteristic of high flux, and can detect multiple indexes simultaneously. The problems that sample pretreatment is time-consuming and labor-consuming, and consumption of detection samples and detection reagents is high are solved, and time, labor cost and reagent consumable cost are saved. Meanwhile, due to the integration function of the microfluidic chip, all the operations which need to be manually completed in a laboratory can be automatically completed by integrating the operations on the chip, so that the pollution of the sample to the environment during manual operation is reduced to the minimum degree.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a schematic diagram of a system according to an embodiment of the present invention;
fig. 2 is a schematic diagram of an ICP-MS injection sample introduction system according to an embodiment of the present invention, in which a represents a sample filling process, B represents an injection process, PP represents a peristaltic pump, SP represents an injection pump (not shown in fig. 1), SV represents an eight-way valve, a represents a first carrier flow inlet, B represents a second carrier flow inlet, C represents a sample inlet, D represents a waste liquid outlet, T represents an atomizer connection port, P1 → P2 represents a first sampling channel, P2 → P3 represents a second sampling channel, P3 → T represents a third sampling channel, a → P1 represents a first carrier flow channel, B → P3 represents a second carrier flow channel, C → P1 represents a third carrier flow channel, D → P2 represents a fourth carrier flow channel, and T represents an atomizer connection port for communicating with a micro atomizer.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all the embodiments. The components of the embodiments of the present application, generally described and illustrated in the figures herein, can be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present application, presented in the accompanying drawings, is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present application without making any creative effort, shall fall within the protection scope of the present application.
As shown in fig. 1-2, the present invention provides a microfluidic multi-channel synchronous detection system for rapid analysis of food safety, comprising:
the peristaltic pump PP is communicated with the input end of the eight-way valve SV and is used for quantitatively transmitting the sample to be processed to the eight-way valve SV;
the injection pump SP is communicated with the input end of the eight-way valve SV and is used for quantitatively transmitting a current to the eight-way valve SV;
the micro-fluidic chip is communicated with the output end of the eight-way valve SV and is used for mixing a sample to be processed with a carrier and forming a sample to be detected after enriching heavy metals or rare earth elements of the sample to be detected;
the micro atomizer is communicated with the output end of the microfluidic chip and is used for obtaining a sample to be detected and simultaneously injecting the sample to be detected into a food safety risk substance analysis instrument for detection;
and the data acquisition device is in data interaction with the food safety risk substance analysis instrument and is used for acquiring a detection result and generating a detection report.
Further preferably, the eight-way valve SV is communicated with the microfluidic chip through a PTFE tube having an inner diameter of 0.25 mm; the inner diameter of the tube of the peristaltic pump PP was 0.19mm and the flow rate was 50. Mu.L/min.
Further preferably, the microfluidic chip comprises:
the atomizer connecting port T is communicated with the micro atomizer,
the third sampling passage P3 → T is for communication with the nebulizer connection port T,
the second sampling passage P2 → P3 communicates with the third sampling passage P3 → T and the fourth current carrying passage D → one end of P2, respectively, the other end of the fourth current carrying passage D → P2 has a waste liquid outlet,
the first sampling channel P1 → P2 is used to communicate with the second sampling channel P2 → P3, the first current carrying channel A → P1 with the first current carrying inlet A, the second current carrying channel B → P3 with the second current carrying inlet B, the third current carrying channel C → P1 with the sample inlet C, respectively;
the waste liquid outlet, the first current-carrying inlet A, the second current-carrying inlet B and the sample inlet C are respectively communicated with the output end of the eight-way valve SV.
Further preferably, the lengths of the first sampling channel P1 → P2, the second sampling channel P2 → P3 and the third sampling channel P3 → T are respectively adjustable within 5-30mm, and the sample output of the micro-atomizer is adjustable within 40-200 μ L.
Further preferably, the lengths of the second sampling channel P2 → P3 and the third sampling channel P3 → T mentioned in the present invention are the same, and the first sampling channel P1 → P2 is 2 to 4 times the sum of the lengths of the second sampling channel P2 → P3 and the third sampling channel P3 → T;
the first sampling channel P1 → P2, the second sampling channel P2 → P3 and the third sampling channel P3 → T have the same channel cross section, the upper and lower bottoms of the channel cross section are respectively 60 and 140 μm, the depth is 40 μm, and the cross section is 0.008mm 2 。
Further preferably, the turning direction of the second current carrying passage B → P3 mentioned in the present invention is toward the atomizer connecting port T.
Further preferably, the flow rate of the carrier fluid output by the syringe pump SP is greater than 4.77 μ L/min, and the flow rate of the carrier fluid output by the syringe pump SP is 5.25 μ L/min.
Further preferably, the number of the micro atomizers is 1 or more, when the number of the micro atomizers is more than one, each micro atomizer is connected with a food safety risk substance analysis instrument, and different types of samples to be detected are transmitted by the aid of the injection pump SP according to the functions of the food safety risk substance analysis instrument; when the quantity of micro atomizer was 1, set up the transmission path with the output intercommunication of this micro atomizer, through the boosting of syringe pump SP, in the food safety risk material analytical instrument of difference is transmitted to simultaneously with the sample that awaits measuring.
Further preferably, the micro atomizer provided by the invention is communicated with various food safety risk substance analysis instruments, and is used for synchronously obtaining a sample to be detected, detecting whether the sample to be detected contains one or more of heavy metals, rare earth elements and organic pollutants, and giving specific content.
Further preferably, the data acquisition device provided by the invention is a mobile terminal, and a wireless parallel data interaction channel is established with various food safety risk substance analysis instruments, so that a detection result is obtained, and a detection report is generated.
Further preferably, the multi-channel synchronous detection system of the present invention has a filling process and an injection process, wherein,
the sample filling process comprises the steps that a standard solution or a sample to be processed sequentially passes through a peristaltic pump PP, an eight-way valve SV and a sample inlet C, enters a first sampling channel P1 → P2, and finally flows out of a waste liquid outlet through a second sampling channel P2 → P3; meanwhile, carrying current flows through the eight-way valve SV through the injection pump SP at the flow rate of 20 muL/min, part of the carrying current enters the micro-atomizer through the second carrying current inlet B and the third sampling channel P3 → T, and the other part of the carrying current flows out of the micro-fluidic control module from the waste liquid outlet, wherein the carrying current is used for carrying a standard solution or a sample and enters the micro-atomizer, the sample filling time is 5s, and the flow rate of the carrying current flowing into the atomizer during sample filling is about 5.25 muL/min;
the injection process comprises the steps of closing the second current-carrying inlet B, the waste liquid outlet and the sample inlet C and opening the first current-carrying inlet A by controlling the eight-way valve SV; the syringe pump SP is controlled to introduce a carrier fluid through the first carrier fluid inlet a into a sampling passage formed by the first sampling passage P1 → P2, the second sampling passage P2 → P3, and the third sampling passage P3 → T, and to push a sample charge in the micro nebulizer to a detection device in a communicating relationship with the micro nebulizer.
The invention also provides a computer application program which is used for realizing the system logic function of the multi-channel synchronous detection system through the computer program, is embedded into the mobile terminal, realizes the control logic of the multi-channel synchronous detection system and realizes the remote control of the multi-channel synchronous detection system.
Example 1, as shown in fig. 1-2, the eight-way valve and the chip were connected as shown in the above figures, and the connecting lines were PTFE tubes each having an inner diameter of 0.25 mm. The inner diameter of the peristaltic pump tube is 0.19mm, and the flow rate is 50 mu L/min. Before the experiment, the chip and all pipelines are washed by ultrapure water and then by current-carrying washing for 30s. The sample injection process comprises two steps of sample filling and injection, wherein in the first step, as shown in a in figure 2, a standard solution or a sample sequentially passes through a peristaltic pump, an eight-way valve and a sampling channel of a chip and finally flows out of a hole D; simultaneously, carrier current (20 muL/min flow rate) flows through the eight-way valve and the chip, part of the carrier current enters the micro atomizer through the P1-T, and the other part of the carrier current flows out of the chip from the hole D. Second, the eight-way valve is switched to the injecting position shown in B in fig. 2, at which time the holes B, C and D are simultaneously closed by the eight-way valve; the carrier current carries the sample plug of the sampling channel into the d-CMN while the ICP-MS acquires the signal in TRA mode. The sample filling time is 5s, the sample injection and analysis time is 40s, and the sample inlet pipeline needs to be flushed by the sample for 30s when the sample is replaced.
As the size of the micro-channel of the micro-fluidic chip is further reduced, the introduction of the nano-liter sample into the ICP-MS is realized. The flow rate of partial carrier flow entering the ICP-MS is measured by a gravimetric method, when the flow rate of the carrier flow is 20 mu L/min, the flow rate flowing into the atomizer during sample filling is about 5.25 mu L/min, and the self-priming effect (the self-priming flow is 4.77 mu L/min) of the atomizer is prevented from interfering the sample filling process. As can be seen from fig. 1, the shape of the sample plug depends on the sampling channel. The upper and lower bottoms of the cross section of the sampling channel are respectively 60 and 140 μm, the depth is 40 μm, and the cross section is 0.008mm 2 . The sample size of the ICP-MS can be varied in the range of 40-200 μ L when the sampling channel length is varied in the range of 5-25 mm. The microfluidic injection system has the advantages of low sample consumption, almost zero sample introduction dead volume, easiness in processing and the like.
Micro and quick pretreatment is carried out by utilizing a micro-fluidic technology, and potential pollutant identification and hazard risk assessment technologies such as food organic pollutants (such as benzopyrene and bisphenol A) and rare earth elements in agricultural products are researched by means of a quick mass spectrum, or ICP-MS, ultraviolet spectroscopy and other series platforms. The research of the technical level is at the leading position in China, and the application and popularization of the technology are not found at present, so that the detection technology and the product of the project have obvious advantages when entering the market.
The invention adopts the micro-fluidic chip technology to carry out the pretreatment of a sample to be detected, and combines the ICP-MS of a back-end mass spectrometer to detect rare earth elements in food and the LC-MS or GC-MS to detect organic pollutants in food. The microfluidic analysis chip has the characteristics of high analysis efficiency, less sample consumption, easiness in miniaturization and portability and the like, and is a research hotspot of current chemistry and biology. The plasma mass spectrometry (ICP.MS) has the characteristics of high sensitivity, wide linear range (7-9 orders of magnitude), simultaneous measurement of multiple elements, simple spectral line, low background and the like, and is one of the best methods for analyzing metal elements. The combination of the two integrates respective advantages, and the metal total amount and the morphological analysis of a trace sample can be solved.
The present invention is described with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems), and computer program products according to embodiments of the invention. It will be understood that each flow and/or block of the flow diagrams and/or block diagrams, and combinations of flows and/or blocks in the flow diagrams and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, embedded processor, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.
In the description of the present invention, it is to be understood that the terms "first", "second" and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implying any number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (10)
1. A microfluidic multi-channel synchronous detection system for rapid analysis of food safety is characterized by comprising:
the peristaltic pump is communicated with the input end of the eight-way valve and is used for quantitatively transmitting the sample to be processed to the eight-way valve;
the injection pump is communicated with the input end of the eight-way valve and is used for quantitatively transmitting the current to the eight-way valve;
the micro-fluidic chip is communicated with the output end of the eight-way valve and is used for mixing the sample to be processed with the carrier current and enriching the heavy metal or rare earth element of the sample to be detected to form a sample to be detected;
the micro atomizer is communicated with the output end of the microfluidic chip and is used for obtaining the sample to be detected and simultaneously injecting the sample to be detected into a food safety risk substance analysis instrument for detection;
and the data acquisition device performs data interaction with the food safety risk substance analysis instrument, is used for acquiring a detection result and generating a detection report.
2. The microfluidic multichannel synchronous detection system for the rapid analysis of food safety according to claim 1, characterized in that:
the eight-way valve is communicated with the microfluidic chip through a PTFE tube with the inner diameter of 0.25 mm;
the inner diameter of the tube of the peristaltic pump is 0.19mm, and the flow rate is 50 mu L/min.
3. The microfluidic multichannel synchronous detection system for the rapid analysis of food safety according to claim 2, characterized in that:
the microfluidic chip includes:
the atomizer connecting port is communicated with the micro atomizer,
the third sampling channel is used for being communicated with the atomizer connecting port,
the second sampling channel is respectively communicated with one end of the third sampling channel and one end of the fourth current-carrying channel, the other end of the fourth current-carrying channel is provided with a waste liquid outlet,
the first sampling channel is used for being respectively communicated with the second sampling channel, the first current-carrying channel with a first current-carrying inlet, the second current-carrying channel with a second current-carrying inlet and the third current-carrying channel with a sample inlet;
the waste liquid outlet, the first current-carrying inlet, the second current-carrying inlet and the sample inlet are respectively communicated with the output end of the eight-way valve.
4. A microfluidic multi-channel synchronous detection system for food safety rapid analysis according to claim 3, characterized in that:
the lengths of the first sampling channel, the second sampling channel and the third sampling channel are respectively 5-30mm and adjustable, and the sample output of the micro atomizer is 40-200 mu L and adjustable.
5. The microfluidic multichannel synchronous detection system for the rapid analysis of food safety according to claim 4, characterized in that:
the lengths of the second sampling channel and the third sampling channel are the same, and the length of the first sampling channel is 2-4 times of the sum of the lengths of the second sampling channel and the third sampling channel;
the first sampling channel, the second sampling channel and the third sampling channel have the same channel cross section, the upper bottom and the lower bottom of the channel cross section are respectively 60 and 140 micrometers, the depth is 40 micrometers, and the sectional area is 0.008mm 2 。
6. The microfluidic multichannel synchronous detection system for the rapid analysis of food safety according to claim 5, characterized in that:
and the turning direction of the second current-carrying channel faces the direction of the connecting port of the atomizer.
7. The microfluidic multichannel synchronous detection system for the rapid analysis of food safety according to claim 6, characterized in that:
the flow rate of the carrier fluid output by the injection pump is 20 mu L/min, and the flow rate of the carrier fluid injected into the sample to be detected by the micro atomizer is 5.25 mu L/min.
8. The microfluidic multichannel synchronous detection system for the rapid analysis of food safety according to claim 7, characterized in that:
the number of the micro atomizers is 1 or more, when the number of the micro atomizers is more, each micro atomizer is connected with one food safety risk substance analysis instrument, and different types of samples to be detected are transmitted through the boosting of the injection pump according to the functions of the food safety risk substance analysis instrument; when the quantity of micro atomizer is 1, set up the transmission path with the output intercommunication of this micro atomizer, through the boosting of syringe pump, will the sample that awaits measuring transmits simultaneously to the difference in the food safety risk material analysis instrument.
9. A microfluidic multichannel synchronous detection system for rapid analysis of food safety according to claim 8, characterized in that:
the micro atomizer is communicated with multiple food safety risk substance analysis instruments and is used for synchronously acquiring the sample to be detected, detecting whether the sample to be detected contains one or more of heavy metals, rare earth elements and organic pollutants, and giving specific content.
10. A microfluidic multichannel synchronous detection system for rapid analysis of food safety according to claim 9, characterized in that:
the data acquisition device is a mobile terminal, and establishes a wireless parallel data interaction channel with various food safety risk substance analysis instruments to acquire the detection result and generate the detection report.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211607399.0A CN115856139A (en) | 2022-12-14 | 2022-12-14 | Microfluidic multi-channel synchronous detection system for food safety rapid analysis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211607399.0A CN115856139A (en) | 2022-12-14 | 2022-12-14 | Microfluidic multi-channel synchronous detection system for food safety rapid analysis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115856139A true CN115856139A (en) | 2023-03-28 |
Family
ID=85672923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211607399.0A Pending CN115856139A (en) | 2022-12-14 | 2022-12-14 | Microfluidic multi-channel synchronous detection system for food safety rapid analysis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115856139A (en) |
-
2022
- 2022-12-14 CN CN202211607399.0A patent/CN115856139A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Miró et al. | Recent advances and future prospects of mesofluidic Lab-on-a-Valve platforms in analytical sciences–A critical review | |
| CN105388309B (en) | The automatic quick determination method of trace iron ions and system and application in Power Plant Water Vapor | |
| US6290910B1 (en) | Continuously variable volume chamber for flow injection analysis | |
| Alexovič et al. | A single-valve sequential injection manifold (SV-SIA) for automation of air-assisted liquid-phase microextraction: stopped flow spectrophotometric determination of chromium (VI) | |
| CA2861452C (en) | Spectrometric device for the analysis of environmental and geological samples | |
| US20150004714A1 (en) | Spectrometric device for the analysis of environmental and geological samples | |
| CN104237217B (en) | A kind of various trace heavy metal ion Simultaneous Detections based on visualization technique | |
| Xu et al. | Flow injection techniques in aquatic environmental analysis: Recent applications and technological advances | |
| US3186235A (en) | Sample supply means for analysis apparatus | |
| CN1749750A (en) | High efficiency liquid phase chromatograph | |
| CN115856139A (en) | Microfluidic multi-channel synchronous detection system for food safety rapid analysis | |
| Marshall | Sequential-injection analysis | |
| CN110044867B (en) | In-situ collection and detection device and method for pesticide residues on surfaces of fruits | |
| US20060210961A1 (en) | Method and system for analysing a liquid sample | |
| CN101959580A (en) | Apparatus system and method for mass analysis of a sample | |
| CN111239097A (en) | Integrated surface enhanced Raman and microfluidic drug fast detection system | |
| CN105424792B (en) | Chip electrophoresis separates and the chip analysis system of plasma mass detection | |
| WO2004009230A1 (en) | A sampling apparatus | |
| Liu et al. | Plug-volume-modulated dilution generator for flask-free chemistry | |
| US10357770B2 (en) | Microfluidic probe for modulating insertion of liquid spacers | |
| CN115902282A (en) | Series injection sampling system based on micro-fluidic technology | |
| van Staden et al. | On-line separation, simultaneous dilution and spectrophotometric determination of zinc in fertilisers with a sequential injection system and xylenol orange as complexing agent | |
| CN206114528U (en) | Atomic fluorescence spectrograph | |
| CN207163915U (en) | A kind of Rapid pesticide residue detection device based on atomic emission spectrum | |
| CN205656123U (en) | Online atomic absorption spectrometer of heavy metal in quality of water |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |