CN115845213A - Closed-loop nerve regulation and control system and regulation and control method based on endogenous brain signals - Google Patents
Closed-loop nerve regulation and control system and regulation and control method based on endogenous brain signals Download PDFInfo
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Abstract
The invention relates to the field of noninvasive neuromodulation, and particularly discloses a closed-loop neuromodulation system and a closed-loop neuromodulation method based on endogenous brain signals, wherein the neuromodulation system comprises a display unit and a control unit, wherein the display unit is used for displaying a stimulation picture to a testee; the electroencephalogram signal collecting unit is used for receiving the electroencephalogram signals after the testee sees the stimulation pictures; the electroencephalogram signal processing unit is used for receiving and analyzing the electroencephalogram signals in real time and judging whether the electroencephalogram signals of the testee are abnormal or not; the transcranial alternating current stimulation unit is used for receiving the abnormal command signals sent by the electroencephalogram signal processing unit and electrically stimulating the target area of the testee.
Description
Technical Field
The invention relates to the field of noninvasive nerve regulation, in particular to a closed-loop nerve regulation system and a regulation method based on endogenous brain signals.
Background
In recent years, the neural regulation and control technology has become the interdisciplinary subject with the fastest development of the combination of neuroscience and biomedical engineering, and has also become the key focus of scientific research, clinical treatment and medical instrument investment. The cranial nerve regulation and control technology is an important method for changing the transfer of brain endogenous nerve signals by invasive or non-invasive means and physical or chemical external technical means such as light, magnetism, electricity, ultrasound and the like so as to cause the change of brain functions. The neural regulation can not only cause the change of the neuron structure in a short time, but also can cause the change of a neural function loop by a specially designed regulation paradigm, thereby restoring or improving the plasticity of the neural synapse connection, being a powerful tool for analyzing the neuron signal conduction, researching the neural loop and explaining the cause and effect relationship between brain functions and behaviors, and being an important means for treating clinical nervous system and psychiatric diseases.
Transcranial alternating current stimulation (tACS) is a non-invasive technique in which a low intensity sinusoidal current is delivered to the scalp to modulate the activity of the cortical brain region, with the frequency of activity of the neuron population at the target brain region being brought to the same frequency as the alternating current is applied. Compared to other neuromodulation devices, during tACS, the spiking activity in the target brain region is increasingly phase locked to the externally applied rhythmic electric field, and the effect observed during stimulation may persist if the applied frequency is similar to the natural frequency of the network. Through the temporal reorganization of specific frequencies of ongoing neuronal activity and the subsequent modulation of synaptic plasticity, tACS is well suited for rehabilitative neuromodulation in populations with neuropsychiatric disorders.
Chinese patent CN114366126A proposes a closed-loop electroencephalogram control method and system, takes electroencephalogram theta rhythm as a marker, and carries out closed-loop electroencephalogram control through a noninvasive brain nerve control technology, but the technical scheme is not targeted, when a tested person only has partial cognition problems and the other part does not have the cognition problems, the tested nerve cannot be controlled, chinese patent CN 113040790A proposes a closed-loop nerve control system based on endogenous brain signals, the technical scheme only indicates how to carry out nerve control under the tasks of opening and closing eyes, and the application range is narrow.
Disclosure of Invention
Aiming at the existing problems, the invention provides a closed-loop nerve regulation and control system and a regulation and control method based on endogenous brain signals, which can effectively solve the problems in the background art.
In order to solve the problems, the invention adopts the following technical scheme:
a closed-loop neuromodulation system based on endogenous brain signals, comprising,
the display unit is used for displaying stimulation pictures to a testee, wherein the stimulation pictures comprise negative pictures, positive pictures and neutral pictures;
the electroencephalogram signal collecting unit is used for receiving the electroencephalogram signals after the testee sees the stimulation pictures;
the electroencephalogram signal processing unit is used for receiving and analyzing the electroencephalogram signals in real time, judging whether the electroencephalogram signals of the testee are abnormal or not, and if the electroencephalogram signals of the testee are abnormal, sending an abnormal instruction;
and the transcranial alternating current stimulation unit is used for receiving the abnormal command signal sent by the electroencephalogram signal processing unit and electrically stimulating the target area of the testee.
As a still further scheme of the invention: the display unit comprises a computer and a display, the computer is connected with the display, the computer stores the stimulation picture and displays the stimulation picture to a testee through the display, the picture is displayed, and specific ERP components are induced.
As a still further scheme of the invention: the stimulus picture is selected from the picture library of the international mood picture system (IAPS library).
As a still further scheme of the invention: the stimulated pictures in the display are displayed for 6s each time, the time of the black screen between adjacent pictures is 12s, and the display time and the time of the black screen can be modified and adjusted according to requirements.
As a still further scheme of the invention: the computer is connected with the electroencephalogram signal processing unit and is used for sending the image tags to the electroencephalogram signal processing unit, and the negative image sending tag 1, the positive image sending tag 2 and the neutral image sending tag 3 are used.
As a still further scheme of the invention: the electroencephalogram signal processing unit judges whether the image is a negative image or not, if the image is the negative image, the ERP score and the theta synchronous score of the testee at the moment are calculated, if unqualified items exist in the two scores, the electrical stimulation is given to the testee through the transcranial alternating current stimulation unit, if the two scores are qualified, the testee is not stimulated, and if the image is not the negative image, the testee is not stimulated.
Also provided is a closed-loop neuromodulation method based on endogenous brain signals, comprising the following steps:
1) Configuring the number of blocks and the rest duration, configuring the presentation time and the stimulation interval time of a stimulation picture of each block and the rest time of each block, configuring a channel of a brain wave component N170, determining qualified scores of ERP (enterprise resource planning) score and theta synchronous score, and setting a target brain area of theta wave band detection;
2) And (3) displaying a stimulation picture: sequentially displaying the stimulation pictures to the testee through a display unit, displaying the pictures and inducing specific ERP components;
3) The electroencephalogram signal processing unit judges whether the stimulation picture is a negative picture, and if not, the display unit displays the next picture after the stimulation interval time;
4) After each negative picture is displayed, the electroencephalogram signal collecting unit receives an electroencephalogram signal and transmits the electroencephalogram signal to the electroencephalogram signal processing unit, the electroencephalogram signal processing unit respectively superposes the ERP obtained by each channel, detects the N170 component of the superposed EPR, scores the superposed EPR, compares the scores with the qualified scores of the ERP scores, and if the scores are lower than the qualified scores of the ERP scores, gives target electrical stimulation to the testee, and the electrical stimulation is continued; if the score is higher than the qualified score of the ERP score, the next step is carried out;
5) And the electroencephalogram signal processing unit respectively calculates the mean value of the theta wave band energy of the left and right frontal lobes under the stimulation of the negative picture, scores the theta wave band energy, compares the scores with the qualified scores of the theta synchronous score and the ERP score, gives target area electrical stimulation to the tested object if the scores are lower than the qualified scores of the theta synchronous score, and displays the next picture after the stimulation interval time if the scores are higher than the qualified scores of the ERP score until all stimulation pictures are displayed.
Compared with the prior art, the invention has the beneficial effects that: 1) The brain activity condition of the testee can be obtained in real time, and the brain activity condition can be regulated and controlled in time under the condition of abnormal electroencephalogram of the testee. The regulation and control are not carried out under the condition that the tested electroencephalogram is normal; 2) The invention carries out fine adjustment on emotion management based on a human-computer interaction mode, and the tested person needs to adjust own emotion and judge subjectively and is objectively monitored by electroencephalogram measurement; 3) The invention introduces an electrical stimulation system to assist the nervous system to adjust the electrical activity and frequency of the neuron group, and can improve the effect of nerve regulation and control; the present invention can be used for treating mood disorders including depression, and restoring abnormal brain waves of patients to normal.
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FIG. 1 is a schematic diagram of a closed-loop neuromodulation system based on endogenous brain signals;
fig. 2 is a flow chart of a closed-loop neuromodulation method based on endogenous brain signals.
In the figure: 1. a display unit; 11. a computer; 12. a display; 2. an electroencephalogram signal collection unit; 3. an electroencephalogram signal processing unit; 4. a transcranial alternating current stimulation unit; 5. a subject.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
As shown in fig. 1, in this embodiment, the present embodiment provides a closed-loop neural regulation and control system based on an endogenous brain signal, which includes a display unit 1, an electroencephalogram signal collection unit 2, an electroencephalogram signal processing unit 3, and a transcranial alternating current stimulation unit 4, where the display unit 1 displays a stimulation picture to a subject 5, the stimulation picture includes a negative picture, a positive picture, and a neutral picture, the stimulation picture is selected from an IAPS library, the display unit 1 includes a computer 11 and a display 12, the computer 11 is electrically connected to the display 12, the computer 11 stores the stimulation picture and displays the stimulation picture to the subject 5 via the display 12, the picture is presented, a specific ERP component is induced, the stimulation picture in the display 12 is presented for 6s each time, and the black screen time between adjacent pictures is 12s, the computer 11 is connected to the electroencephalogram signal processing unit 3 and is used for sending a picture tag to the electroencephalogram signal processing unit 3, and the negative picture sending tag 1, the positive picture sending tag 2 and the neutral picture sending tag 3, the electroencephalogram signal collection unit receives an electroencephalogram signal after the stimulation picture is viewed by the subject 5, and transmits the electroencephalogram signal to the brain signal processing unit 3, and judges whether an electroencephalogram signal processing unit 4, and if an electroencephalogram signal processing unit receives an electroencephalogram signal processing instruction to send an abnormal electroencephalogram signal, and sends an electroencephalogram signal, if an electroencephalogram signal processing unit 4 exists; the transcranial alternating current stimulation unit 4 is a tACS, receives an abnormal command signal sent by the electroencephalogram signal processing unit 3, and electrically stimulates a target area of the testee 5, specifically, the electroencephalogram signal processing unit 3 judges whether the picture is a negative picture, if the picture is the negative picture, the ERP score and the theta synchronous score of the testee 5 at the moment are calculated, if the two scores have unqualified items, the electrical stimulation is given to the testee 5 through the transcranial alternating current stimulation unit 4, if both scores are qualified, the testee is not stimulated, and if the picture is not the negative picture, the testee is not stimulated.
As shown in fig. 2, in this embodiment, a closed-loop neuromodulation method based on an endogenous brain signal is provided, which includes the following steps:
1) Selecting 100 stimulation pictures from an IAPS (inter-personal area service) library, wherein 40 negative pictures, 40 positive pictures and 20 neutral pictures are played randomly through a display connected with a computer and divided into four blocks, 25 pictures are displayed in each block respectively, each picture displays 6s, the black screen time between every two pictures is 12s and serves as stimulation interval time, five-minute rest time exists between every two blocks, an experiment is ended after the four blocks are ended, a channel of an electroencephalogram component N170 is configured in an electroencephalogram signal processing unit, qualified scores of an ERP score and a theta synchronous score are determined, the qualified scores of the ERP score and the theta synchronous score are 80, and a target brain area of theta waveband detection is set;
2) The method comprises the steps that stimulation pictures are displayed to a testee in sequence through a display unit, the pictures are presented, specific ERP components are induced, picture tags are sent to an electroencephalogram signal processing unit, a negative picture sending tag 1, a positive picture sending tag 2 and a neutral picture sending tag 3 are sent;
3) The electroencephalogram signal processing unit judges whether the stimulation picture is a negative picture, and if not, the display unit displays the next picture after 12 s;
4) After each negative picture is displayed, the electroencephalogram signal collecting unit receives the electroencephalogram signals and transmits the electroencephalogram signals to the electroencephalogram signal processing unit, the electroencephalogram signal processing unit respectively superposes the ERP obtained by each channel, N170 component detection is carried out on the superposed EPR, and the detection parameters comprise: latency (ms) and response amplitude (uV), and the scoring is as follows:
therein is negative n170Amp Average amplitudes of all configured channels representing the negative picture evoked N170;
in n170Amp The average amplitude of all channels representing the neutral pictures taken before the experiment induced N170.
Comparing the score with the qualified score of the ERP score, and if the score is lower than the qualified score of the ERP score, carrying out alternating current stimulation of 2mA of a forehead leaf (dlPFC) on the back outer side of the target area on the tACS for 10 seconds; if the score is higher than the qualified score of the ERP score, the next step is carried out;
5) After the display of each negative picture is finished, the electroencephalogram signal processing unit respectively calculates the mean value of theta wave band energy of the left and right frontal lobes under the stimulation of the negative picture and carries out grading, and the grading formula is as follows:
wherein, theta L negativity Is the mean value of the theta band energy of the left prefrontal lobe under the stimulation of a negative picture, theta R is negative Is the mean value of the theta band energy of the right frontal lobe under the stimulation of a negative picture, theta L is neutral Is the mean value of the theta band energy of the left prefrontal lobe under the stimulation of a neutral picture, theta R is neutral Is the mean value of the theta band energy of the right prefrontal lobe under stimulation of neutral pictures.
And comparing the scores with the qualified scores of the theta synchronous score and the ERP score, if the scores are scored 2 If the score is lower than the qualified score of theta synchronous score, the tACS gives 2mA electrical stimulation to the target area (dlPFC) to be tested, the electrical stimulation lasts for 10 seconds, and if the score is higher than the qualified score of ERP score, the next picture is displayed after the screen blacking time is 12 seconds until all stimulation pictures are displayed.
In each negative picture, the steps 4) and 5) are circularly operated until the grade and the grade are obtained 2 Is higher than the qualified score of the corresponding ERP score and theta sync score.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. A closed-loop neuromodulation system based on endogenous brain signals, comprising,
the display unit is used for displaying stimulation pictures to a testee, wherein the stimulation pictures comprise negative pictures, positive pictures and neutral pictures;
the electroencephalogram signal collecting unit is used for receiving the electroencephalogram signals after the testee sees the stimulation pictures;
the electroencephalogram signal processing unit is used for receiving and analyzing the electroencephalogram signals in real time, judging whether the electroencephalogram signals of the testee are abnormal or not, and if the electroencephalogram signals of the testee are abnormal, sending an instruction to display the abnormal;
and the transcranial alternating current stimulation unit is used for receiving the abnormal command signal sent by the electroencephalogram signal processing unit and electrically stimulating the target area of the testee.
2. The system and the method for closed-loop neuromodulation based on the intrinsic brain signal as claimed in claim 1, wherein the display unit comprises a computer and a display, the computer is electrically connected with the display, the computer stores a stimulation picture and displays the stimulation picture to the subject through the display, the picture is displayed, and the specific ERP component is induced.
3. The system and method for closed-loop neuromodulation based on intrinsic brain signals as in claim 2, wherein the stimulation picture is selected from a library of pictures of the international mood picture system.
4. The system and method of claim 2, wherein the stimulation pictures in the display each show 6s each time with a black screen time of 12s between adjacent pictures.
5. The system and the method for closed-loop neuromodulation based on the endogenous brain signals according to claim 2, wherein the computer is connected with the electroencephalogram signal processing unit and is used for sending tags to the electroencephalogram signal processing unit, and the negative picture sending tag 1, the positive picture sending tag 2 and the neutral picture sending tag 3 are used.
6. The system and method of claim 1, wherein the EEG processing unit determines whether the image is a negative image, and if the image is a negative image, the ERP score and the theta synchronous score of the subject are calculated, if the two scores are not qualified, the subject is electrically stimulated by the transcranial AC stimulation unit, if the two scores are qualified, the subject is not stimulated, and if the image is not a negative image, the subject is not stimulated.
7. A closed-loop nerve regulation and control method based on endogenous brain signals is characterized by comprising the following steps:
1) Configuring the number of pictures and the rest time of each block, configuring the presentation time, the stimulation interval time and the rest time among 2 blocks of each picture, configuring a channel of an electroencephalogram component N170, determining qualified scores of ERP (enterprise resource planning) score and theta synchronous score, and setting a target brain area of theta wave band detection;
2) The display unit displays the stimulating pictures to the testee in sequence, displays the pictures and induces specific ERP components;
3) The electroencephalogram signal processing unit judges whether the stimulation picture is a negative picture, and if not, the display unit displays the next picture after the stimulation interval time;
4) After each negative picture is displayed, the electroencephalogram signal collecting unit receives an electroencephalogram signal and transmits the electroencephalogram signal to the electroencephalogram signal processing unit, the electroencephalogram signal processing unit respectively superposes the ERP obtained by each channel, detects the N170 component of the superposed EPR, scores the superposed EPR, compares the scores with the qualified scores of the ERP scores, and if the scores are lower than the qualified scores of the ERP scores, gives target electrical stimulation to the testee, and the electrical stimulation is continued; if the score is higher than the qualified score of the ERP score, the next step is carried out;
5) And the electroencephalogram signal processing unit respectively calculates the mean value of theta wave band energy of the left and right frontal lobes under the stimulation of the negative picture, scores the values, compares the scores with the qualified scores of theta synchronous score and ERP score, gives target area electrical stimulation to the tested object if the scores are lower than the qualified scores of the theta synchronous score, and displays the next picture after stimulation interval time if the scores are higher than the qualified scores of the ERP score until all stimulation pictures are displayed.
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