CN115825312B

CN115825312B - Chromatographic detection data interaction method, chromatographic detection data interaction device, chromatographic detection data interaction equipment and computer readable medium

Info

Publication number: CN115825312B
Application number: CN202310148293.7A
Authority: CN
Inventors: 王东强; 冀禹璋
Original assignee: China Spectrum Tech Beijing Technology Co ltd
Current assignee: China Spectrum Tech Beijing Technology Co ltd
Priority date: 2023-02-22
Filing date: 2023-02-22
Publication date: 2023-05-12
Anticipated expiration: 2043-02-22
Also published as: CN115825312A

Abstract

Embodiments of the present disclosure disclose chromatographic detection data interaction methods, apparatus, devices and computer readable media. One embodiment of the method comprises the following steps: for each of the sets of chromatographic information, the following processing steps are performed: performing principal component analysis processing on the chromatographic analysis information included in the chromatographic information to generate chromatographic principal component analysis information; detecting the chromatographic principal component analysis information according to the reference chromatographic characteristic information table to generate a detection result; determining each chromatographic information of which the detection result represents abnormality as an abnormal chromatographic information group, and determining each chromatographic information of which the detection result represents normal as a normal chromatographic information group; marking each piece of abnormal chromatographic information in the abnormal chromatographic information group according to each detection result corresponding to the abnormal chromatographic information group so as to generate abnormal marked chromatographic information; and storing the anomaly signature chromatographic information set into an anomaly cache node. This embodiment relieves the storage pressure and the reading pressure of the database.

Description

Chromatographic detection data interaction method, chromatographic detection data interaction device, chromatographic detection data interaction equipment and computer readable medium

Technical Field

Embodiments of the present disclosure relate to the field of chromatographic data interaction, and in particular, to chromatographic detection data interaction methods, apparatuses, devices, and computer-readable media.

Background

The chromatograph is a device for performing chromatographic analysis, has high sensitivity and automation degree, and is widely applied to chemical product analysis experiments. Currently, for the storage of chromatographic test data, the following methods are generally adopted: and storing the detected chromatographic test data in a preset database.

However, the following technical problems generally exist in the above manner:

1. the detected chromatographic test data are not classified and stored, so that abnormal chromatographic test data and normal chromatographic test data are stored in the same database, and when the chromatographic test data are more, the storage pressure and the reading pressure of the database are increased;

2. when the chromatographic test data volume is large, the query efficiency is low, more front indexes need to be established, and the waste of storage space is easily caused.

Disclosure of Invention

The disclosure is in part intended to introduce concepts in a simplified form that are further described below in the detailed description. The disclosure is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used to limit the scope of the claimed subject matter.

Some embodiments of the present disclosure propose chromatographic detection data interaction methods, apparatuses, electronic devices and computer-readable media to solve the technical problems mentioned in the background section above.

In a first aspect, some embodiments of the present disclosure provide a chromatography detection data interaction method, the method comprising: acquiring a chromatographic information set generated by a chromatograph, wherein the chromatographic information in the chromatographic information set comprises: chromatograph equipment information, environmental parameter information, and chromatographic information, the chromatographic information including a plurality of pieces of chromatographic data; for each of the above sets of chromatographic information, the following processing steps are performed: performing principal component analysis processing on the chromatographic analysis information included in the chromatographic information to generate chromatographic principal component analysis information, wherein the chromatographic principal component analysis information includes a plurality of chromatographic characteristic information; determining a reference chromatographic characteristic information table corresponding to chromatograph equipment information included in the chromatographic information; detecting the chromatographic principal component analysis information according to the reference chromatographic characteristic information table to generate a detection result; determining each chromatographic information of which the detection result represents abnormality as an abnormal chromatographic information group, and determining each chromatographic information of which the detection result represents normal as a normal chromatographic information group; marking each piece of abnormal chromatographic information in the abnormal chromatographic information group according to each detection result corresponding to the abnormal chromatographic information group so as to generate abnormal marked chromatographic information, and obtaining the abnormal marked chromatographic information group; in response to receiving the information storage instruction, determining abnormal chromatographic information cache information and normal chromatographic information cache information; locking the abnormal cache node corresponding to the abnormal chromatographic information cache information, and storing the abnormal marking chromatographic information set into the abnormal cache node in response to determining that the abnormal cache node is successfully locked; and performing locking processing on a normal cache node corresponding to the normal chromatographic information cache information, and storing the normal chromatographic information set in the normal cache node in response to determining that the normal cache node is successfully locked.

In a second aspect, some embodiments of the present disclosure provide a chromatography detection data interaction device, the device comprising: an acquisition unit configured to acquire a set of chromatographic information generated by a chromatograph, wherein the chromatographic information in the set of chromatographic information includes: chromatograph equipment information, environmental parameter information, and chromatographic information, the chromatographic information including a plurality of pieces of chromatographic data; an analysis unit configured to perform, for each of the above-described sets of chromatographic information, the following processing steps: performing principal component analysis processing on the chromatographic analysis information included in the chromatographic information to generate chromatographic principal component analysis information, wherein the chromatographic principal component analysis information includes a plurality of chromatographic characteristic information; determining a reference chromatographic characteristic information table corresponding to chromatograph equipment information included in the chromatographic information; detecting the chromatographic principal component analysis information according to the reference chromatographic characteristic information table to generate a detection result; a first determination unit configured to determine, as an abnormal chromatographic information group, respective chromatographic information whose detection result characterizes the abnormality, and determine, as a normal chromatographic information group, respective chromatographic information whose detection result characterizes the abnormality; a marking unit configured to mark each piece of abnormal chromatographic information in the abnormal chromatographic information group according to each detection result corresponding to the abnormal chromatographic information group so as to generate abnormal marked chromatographic information, thereby obtaining an abnormal marked chromatographic information group; a second determination unit configured to determine abnormal chromatographic information buffer information and normal chromatographic information buffer information in response to receiving the information storage instruction; a first storage unit configured to lock an abnormal cache node corresponding to the abnormal chromatographic information cache information, and store the abnormal chromatographic information set in the abnormal cache node in response to determining that the abnormal cache node is successfully locked; and the second storage unit is configured to lock the normal cache node corresponding to the normal chromatographic information cache information and store the normal chromatographic information group into the normal cache node in response to determining that the normal cache node is successfully locked.

In a third aspect, some embodiments of the present disclosure provide an electronic device comprising: one or more processors; a storage device having one or more programs stored thereon, which when executed by one or more processors causes the one or more processors to implement the method described in any of the implementations of the first aspect above.

In a fourth aspect, some embodiments of the present disclosure provide a computer readable medium having a computer program stored thereon, wherein the program, when executed by a processor, implements the method described in any of the implementations of the first aspect above.

The above embodiments of the present disclosure have the following advantageous effects: by the chromatographic detection data interaction method of some embodiments of the present disclosure, the storage pressure and the reading pressure of the database are relieved. Specifically, the reason why the storage pressure and the reading pressure of the database are increased is that: the detected chromatographic test data are not classified and stored, so that abnormal chromatographic test data and normal chromatographic test data are stored in the same database, and when the chromatographic test data are more, the storage pressure and the reading pressure of the database are increased. Based on this, the chromatographic detection data interaction method of some embodiments of the present disclosure first acquires a chromatographic information set generated by a chromatograph. Wherein, the chromatographic information in the chromatographic information set includes: chromatograph apparatus information, environmental parameter information, and chromatographic information including a plurality of pieces of chromatographic data. Next, for each of the above-described sets of chromatographic information, the following processing steps are performed: first, principal component analysis processing is performed on the chromatographic information included in the above chromatographic information to generate chromatographic principal component analysis information. Wherein the chromatographic principal component analysis information includes a plurality of chromatographic characteristic information. Thus, data support is provided for detection of chromatographic test data. Next, a reference chromatographic characteristic information table corresponding to the chromatograph equipment information included in the chromatographic information is determined. Next, the chromatographic principal component analysis information is detected based on the reference chromatographic characteristic information table to generate a detection result. Thus, the chromatographic test data can be detected based on the predetermined reference chromatographic characteristic information table of the corresponding chromatograph. Then, each piece of the chromatographic information of which the detection result characterizes abnormality is determined as an abnormal chromatographic information group, and each piece of the chromatographic information of which the detection result characterizes normal is determined as a normal chromatographic information group. Thus, the chromatographic test data generated by the chromatograph can be classified. And then, marking each piece of abnormal chromatographic information in the abnormal chromatographic information group according to each detection result corresponding to the abnormal chromatographic information group so as to generate abnormal marked chromatographic information, and obtaining the abnormal marked chromatographic information group. Thus, the abnormal chromatographic characteristic information in the abnormal chromatographic information can be marked. And then, in response to receiving the information storage instruction, determining abnormal chromatographic information cache information and normal chromatographic information cache information. Thereby, it is convenient to determine the storage path of the abnormal color spectrum information and the normal color spectrum information. Finally, locking the abnormal cache node corresponding to the abnormal chromatographic information cache information, and storing the abnormal marking chromatographic information set into the abnormal cache node in response to the successful locking of the abnormal cache node; and performing locking processing on a normal cache node corresponding to the normal chromatographic information cache information, and storing the normal chromatographic information set in the normal cache node in response to determining that the normal cache node is successfully locked. Therefore, the chromatographic information can be classified and stored, and the storage pressure and the reading pressure of the database are relieved.

Drawings

The above and other features, advantages, and aspects of embodiments of the present disclosure will become more apparent by reference to the following detailed description when taken in conjunction with the accompanying drawings. The same or similar reference numbers will be used throughout the drawings to refer to the same or like elements. It should be understood that the figures are schematic and that elements and components are not necessarily drawn to scale.

FIG. 1 is a flow chart of some embodiments of a chromatography detection data interaction method according to the present disclosure;

FIG. 2 is a schematic structural view of some embodiments of a chromatography detection data interaction device according to the present disclosure;

fig. 3 is a schematic structural diagram of an electronic device suitable for use in implementing some embodiments of the present disclosure.

Detailed Description

Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While certain embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete. It should be understood that the drawings and embodiments of the present disclosure are for illustration purposes only and are not intended to limit the scope of the present disclosure.

It should be noted that, for convenience of description, only the portions related to the present invention are shown in the drawings. Embodiments of the present disclosure and features of embodiments may be combined with each other without conflict.

It should be noted that the terms "first," "second," and the like in this disclosure are merely used to distinguish between different devices, modules, or units and are not used to define an order or interdependence of functions performed by the devices, modules, or units.

It should be noted that references to "one", "a plurality" and "a plurality" in this disclosure are intended to be illustrative rather than limiting, and those of ordinary skill in the art will appreciate that "one or more" is intended to be understood as "one or more" unless the context clearly indicates otherwise.

The names of messages or information interacted between the various devices in the embodiments of the present disclosure are for illustrative purposes only and are not intended to limit the scope of such messages or information.

The present disclosure will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.

Fig. 1 is a flow chart of some embodiments of chromatography detection data interaction methods according to some embodiments of the present disclosure. A flow 100 of some embodiments of a chromatography detection data interaction method according to the present disclosure is shown. The chromatographic detection data interaction method comprises the following steps:

Step 101, acquiring a chromatographic information set generated by a chromatograph.

In some embodiments, the executing entity (e.g., server) of the chromatographic detection data interaction method may obtain the chromatographic information set generated by the chromatograph through a wired connection or a wireless connection. Wherein, the chromatographic information in the chromatographic information set includes: chromatograph apparatus information, environmental parameter information, and chromatographic information including a plurality of pieces of chromatographic data. The chromatograph equipment information can refer to information such as basic hardware configuration, equipment model and the like of the chromatograph, and the chromatograph equipment information is determined so as to be convenient for further detection of the chromatograph information. The environmental parameter information may refer to environmental information of the chromatograph while running, and may include, but is not limited to: supply voltage, illumination intensity, air cleanliness, etc. Chromatographic information may refer to chromatographic data generated by a chromatograph during analysis. The plurality of chromatographic data may include, but is not limited to: device temperature, internal pressure, carrier gas type, column temperature, volume flow, baseline, peak time, peak height, peak area, peak position, symmetry factor, number of trays, retention volume, relative retention value, retention index, etc.

Step 102, for each piece of chromatographic information in the set of chromatographic information, performing the following processing steps:

and 1021, performing principal component analysis processing on the chromatographic information included in the chromatographic information to generate chromatographic principal component analysis information.

In some embodiments, the execution body may perform principal component analysis processing on the chromatographic information included in the chromatographic information to generate chromatographic principal component analysis information. Wherein the chromatographic principal component analysis information includes a plurality of chromatographic characteristic information. Here, the principal component analysis may refer to PCA (Principal Components Analysis) analysis. Here, the chromatographic principal component analysis information may include a first principal component variable and a second principal component variable. Here, the first principal component variable and the second principal component variable may be obtained by PCA (Principal Components Analysis) dimension reduction analysis from a plurality of pieces of chromatographic characteristic information (apparatus temperature, internal pressure, carrier gas type, column temperature, volume flow rate, base line, peak out time, peak height, peak area, peak position, symmetry factor, number of trays, retention volume, relative retention value, retention index) included in the chromatographic information. The first principal component variable and the second principal component variable each contain chromatographic characteristic information (chromatographic data) included in the chromatographic information.

Step 1022, determining a reference chromatographic characteristic information table corresponding to the chromatograph equipment information included in the chromatographic information.

In some embodiments, the execution body may determine a reference chromatographic characteristic information table corresponding to chromatograph device information included in the chromatographic information. That is, there is a corresponding reference chromatographic characteristic information table for each chromatograph. The reference chromatographic characteristic information table may be a table for comparing standard chromatographic characteristic information of the detection chromatographic information. The reference chromatographic characteristic information table may be preset. That is, the reference chromatographic characteristic information table associated with the chromatograph device number may be determined based on the chromatograph device number included in the chromatograph device information.

Step 1023, detecting the chromatographic principal component analysis information according to the reference chromatographic characteristic information table to generate a detection result.

In some embodiments, the execution body may detect the chromatographic principal component analysis information according to the reference chromatographic characteristic information table to generate a detection result.

In practice, first, for each piece of chromatographic characteristic information included in the above-described chromatographic principal component analysis information, the following detection steps are performed:

First, selecting reference chromatographic characteristic information corresponding to the chromatographic characteristic information from the reference chromatographic characteristic information table as target reference chromatographic characteristic information. Wherein the chromatographic characteristic information includes the same chromatographic characteristic name as the target reference chromatographic characteristic information.

And a second step of determining whether the chromatographic data included in the chromatographic characteristic information is within the chromatographic data range included in the target reference chromatographic characteristic information.

And a third step of generating a sub-result representing abnormality of the chromatographic characteristic information in response to determining that the chromatographic data included in the chromatographic characteristic information is not within the chromatographic data included in the target reference chromatographic characteristic information.

Then, the generated sub-results are combined into a detection result corresponding to the analysis information of the main component of the chromatograph.

And 103, determining each piece of chromatographic information of which the detection result represents abnormality as an abnormal chromatographic information group, and determining each piece of chromatographic information of which the detection result represents normal as a normal chromatographic information group.

In some embodiments, the executing entity may determine each piece of chromatographic information that the detection result represents an abnormality as an abnormal chromatographic information group, and each piece of chromatographic information that the detection result represents a normal as a normal chromatographic information group. That is, the chromatographic information corresponding to the detection result of the presence of the abnormal sub-result characterizes the abnormality.

And 104, marking each piece of abnormal chromatographic information in the abnormal chromatographic information group according to each detection result corresponding to the abnormal chromatographic information group so as to generate abnormal marked chromatographic information, and obtaining the abnormal marked chromatographic information group.

In some embodiments, the executing body may mark each piece of abnormal chromatographic information in the abnormal chromatographic information set according to each detection result corresponding to the abnormal chromatographic information set, so as to generate abnormal marked chromatographic information, and obtain the abnormal marked chromatographic information set.

In practice, the execution subject may label each of the abnormality chromatographic information in the abnormality chromatographic information group by:

first, determining the detection result corresponding to the abnormal chromatographic information.

And a second step of marking, for each abnormal sub-result included in the detection result, the chromatographic data corresponding to the sub-result among the chromatographic data included in the abnormal chromatographic information. Here, the mark may be a typeface tag marked with an abnormality. The chromatographic characteristic information corresponding to the sub-result is the chromatographic data.

Step 105, in response to receiving the information storage instruction, determining abnormal chromatographic information cache information and normal chromatographic information cache information.

In some embodiments, the executing entity may determine the abnormal chromatographic information cache information and the normal chromatographic information cache information in response to receiving the information storage instruction. The information storage instruction may be an instruction for storing an abnormal chromatographic information set and a normal chromatographic information set. The abnormal color spectrum information cache information may be path information of a cache server/node that is preset to store the abnormal color spectrum information. The normal chromatographic information cache information may be path information of a cache server/node previously set for storing the normal chromatographic information. That is, the anomaly chromatographic information cache information may be uniquely directed to a storage node. The normal chromatographic information buffer information may be uniquely directed to a storage node.

And 106, locking the abnormal cache node corresponding to the abnormal chromatographic information cache information, and storing the abnormal chromatographic information set into the abnormal cache node in response to the successful locking of the abnormal cache node.

In some embodiments, the execution body may perform locking processing on an exception cache node corresponding to the exception chromatographic information cache information, and store the exception flag chromatographic information set in the exception cache node in response to determining that locking of the exception cache node is successful. The anomaly cache node may be a storage node for storing an anomaly tagged chromatographic information set. For example, the exception cache node may be a storage server. The locking process may refer to setting a control variable that controls that the shared resource cannot be accessed by other processes. That is, when storing the abnormality flag chromatograph information set, the abnormality cache node is prevented from being accessed by other processes. The abnormality flag chromatographic information in the abnormality flag chromatographic information group includes chromatograph apparatus information including: chromatograph equipment number. The chromatograph device number may uniquely represent a chromatograph.

In practice, the execution subject may store the anomaly flag chromatographic information set in the anomaly cache node by:

first, determining whether a chromatograph device number corresponding to the abnormality flag chromatograph information set exists in a preset chromatograph device number set. Here, the chromatograph device number group may refer to individual device numbers of the chromatograph of high access amount/high read frequency. That is, it is determined whether or not there is the same chromatograph device number as the chromatograph device number included in the above-described abnormality flag chromatograph information group in the chromatograph device number group. The chromatograph devices included in the abnormality marker chromatograph information set have the same numbers.

And a second step of performing clustering processing on the abnormal mark chromatographic information set according to a preset capacity threshold value to obtain the abnormal mark chromatographic information set in response to determining that the chromatographic equipment number corresponding to the abnormal mark chromatographic information set exists in the chromatographic equipment number set.

In practice, the second step may comprise the following sub-steps:

a first sub-step of determining the data capacity of each anomaly flag chromatographic information in the anomaly flag chromatographic information set to obtain a data capacity set. Here, the data capacity may refer to the data capacity of the abnormality flag chromatographic information.

And a second sub-step of performing clustering processing on the anomaly signature information set according to the data capacity set in response to determining that the sum of the data capacities in the data capacity set is greater than the capacity threshold value, thereby obtaining an anomaly signature information set. And the sum of the data capacities corresponding to the abnormal mark chromatographic information set groups is smaller than or equal to the capacity threshold. That is, the clustering process may be to divide the abnormality marker color spectrum information group so that the sum of the respective data capacities corresponding to the divided abnormality marker color spectrum information sets is equal to or less than the capacity threshold. That is, the sum of the data capacities corresponding to the anomaly flag chromatographic information sets is equal to or less than the capacity threshold.

Third, for each anomaly flag chromatographic information set in the anomaly flag chromatographic information set group, performing the following storage steps:

a first substep, in response to determining that the information capacity corresponding to the anomaly signature chromatographic information set is greater than a target capacity threshold, of storing the anomaly signature chromatographic information set in a first chromatographic information caching node of the anomaly caching node. For example, the first color spectrum information cache node may be an HDD (Hard Disk Drive) storage Disk of the anomaly cache node.

And a second sub-step of storing the anomaly flag color spectrum information set in a second color spectrum information cache node of the anomaly cache node in response to determining that the information capacity corresponding to the anomaly flag color spectrum information set is equal to or less than the target capacity threshold. For example, the second log cache pool may refer to an SSD solid state disk (Solid State Drives) of the abnormal cache node

And 107, locking the normal cache node corresponding to the normal chromatographic information cache information, and storing the normal chromatographic information set in the normal cache node in response to determining that the normal cache node is successfully locked.

In some embodiments, the executing body may perform locking processing on a normal cache node corresponding to the normal chromatographic information cache information, and store the normal chromatographic information set in the normal cache node in response to determining that locking of the normal cache node is successful.

When the abnormal and normal sets of chromatographic information are stored, the abnormal and normal sets of chromatographic information are compressed. That is, the compressed abnormal chromatographic information set and the normal chromatographic information set are stored.

Alternatively, in response to determining that the above-described group of anomaly flag chromatographic information failed to be stored, storage failure information is generated.

In some embodiments, the execution body may generate the storage failure information in response to determining that the abnormality flag chromatographic information set fails to be stored. Here, the storage failure information may indicate that the abnormality cache node has failed to store the abnormality flag chromatographic information set.

Optionally, determining the storage failure times corresponding to the abnormal cache nodes within a preset time period.

In some embodiments, the execution body may determine the number of storage failures corresponding to the abnormal cache node in a preset period of time. Here, the preset time period may refer to a preset history time period. That is, the number of storage failures of the abnormal cache node within a preset period of time may be determined.

Optionally, in response to determining that the number of storage failures is equal to or less than a preset threshold, the anomaly signature chromatographic information set is stored again in the anomaly cache node.

In some embodiments, the execution body may store the anomaly flag chromatographic information set in the anomaly cache node again in response to determining that the number of storage failures is equal to or less than a preset threshold. The setting of the preset threshold is not limited.

Optionally, in response to determining that the abnormality flag chromatographic information set fails to be stored again, the abnormality flag chromatographic information set is stored into a preset candidate cache node.

In some embodiments, the executing entity may store the anomaly flag chromatographic information set in a preset candidate cache node in response to determining that the anomaly flag chromatographic information set fails to be stored again. Here, the preset candidate cache node may be a preset candidate storage server.

Optionally, it is determined whether the received chromatographic information query request contains a chromatographic key field.

In some embodiments, the execution entity may determine whether the received chromatographic information query request contains a chromatographic key field. The above-mentioned chromatographic key field may be a key for querying chromatographic information.

Optionally, in response to determining that the chromatographic information query request includes a chromatographic key field, obtaining a compressed chromatographic information set corresponding to a chromatographic query condition corresponding to the chromatographic information query request according to the chromatographic query condition.

In some embodiments, the executing entity may obtain, in response to determining that the chromatographic information query request includes a chromatographic key field, a compressed chromatographic information set corresponding to a chromatographic query condition corresponding to the chromatographic information query request. The chromatographic query condition may be a query constraint that does not include a chromatographic key field query condition corresponding to the chromatographic key field. For example, the chromatographic inquiry condition may be a chromatographic information size inquiry condition. For example, the chromatographic information size query condition may be that the size of the compressed chromatographic information is equal to or smaller than a preset size. The setting of the preset size is not limited. For example, the preset size may be 1M. The compressed chromatography information may be compressed chromatography information. For example, the execution subject may acquire, as the set of compression chromatogram information, each piece of compression chromatogram information satisfying the chromatogram inquiry condition from the stored pieces of compression chromatogram information.

In practice, according to the chromatographic inquiry condition corresponding to the chromatographic information inquiry request, the execution body may acquire the compressed chromatographic information set corresponding to the chromatographic inquiry condition through the following steps:

and step one, determining chromatographic inquiry conditions according to the chromatographic information inquiry request. Wherein the chromatographic information inquiry request comprises at least one of the following: a chromatographic information path condition, a chromatographic information time condition, a chromatographic information query quantity condition, the chromatographic information query quantity condition including at least one of: chromatographic information path conditions, chromatographic information time conditions, chromatographic information query quantity conditions. The chromatographic information path condition may be that a path corresponding to the compressed chromatographic information is a query chromatographic information path. The query chromatographic information path may be a retrieval path included in the above chromatographic information query request for querying chromatographic information. The chromatographic information time condition may be that a storage time corresponding to the compressed chromatographic information is within a query chromatographic information storage time period. The query chromatographic information storage period may be a period for querying the chromatographic information according to the storage time, which is included in the above-described chromatographic information query request. The above condition for the number of the inquired chromatographic information may be that the number of the inquired compressed chromatographic information is the inquired number. The number of queries may be the number of chromatographic information that need to be queried.

And secondly, acquiring a compressed chromatographic information set corresponding to the chromatographic inquiry conditions according to the chromatographic inquiry conditions. Thus, the conditions other than the conditions corresponding to the key fields of the chromatogram can be combined into the chromatographic inquiry conditions.

Optionally, in response to determining that there is prestored no-result compressed chromatography information corresponding to the chromatography key field, filtering the compressed chromatography information set according to the prestored no-result compressed chromatography information corresponding to the chromatography key field.

In some embodiments, the execution body may filter the compressed chromatography information set according to prestored non-result compressed chromatography information corresponding to the chromatography key field in response to determining that there is prestored non-result compressed chromatography information corresponding to the chromatography key field. The no-result compressed chromatographic information corresponding to the chromatographic key field may be the compressed chromatographic information which is not searched according to the chromatographic key field. Here, the number of the non-result compressed color spectrum information corresponding to the color spectrum key field may be one or more, and may be determined by the number of the non-result compressed color spectrum information corresponding to the color spectrum key field stored in advance. In practice, the execution body may determine each of the non-result compressed chromatography information corresponding to the chromatography key field stored in advance as a non-result compressed chromatography information set. Then, each piece of compression chromatogram information identical to each piece of non-result compression chromatogram information in the non-result compression chromatogram information set may be deleted from the compression chromatogram information set to filter the compression chromatogram information set.

Optionally, according to the field query condition corresponding to the chromatographic key field, each piece of compressed chromatographic information meeting the field query condition is selected from the filtered compressed chromatographic information set as a chromatographic information query result.

In some embodiments, the execution body may select, from the filtered compressed chromatographic information set, each compressed chromatographic information satisfying the field query condition as a chromatographic information query result according to the field query condition corresponding to the chromatographic key field. The field query condition may be a condition for querying the chromatographic information with the chromatographic key field. For example, the field query condition may include the key field for compressing the key field corresponding to the chromatographic information. In practice, the executing entity may select, from the filtered compressed chromatographic information set, each compressed chromatographic information whose corresponding key field includes the chromatographic key field. The selected individual compressed chromatographic information may then be determined as a chromatographic information query result.

Optionally, the result of the inquiry of the chromatographic information is sent to an inquiry terminal corresponding to the inquiry request of the chromatographic information.

In some embodiments, the execution body may send the result of the inquiry of the chromatographic information to an inquiry terminal corresponding to the inquiry request of the chromatographic information. That is, the query terminal may be a terminal that transmits a chromatographic information query request.

Optionally, generating a no-result compressed chromatographic information set corresponding to the chromatographic key field according to the chromatographic information query result.

In some embodiments, the execution body may generate a non-result compressed chromatographic information set corresponding to the chromatographic key field according to the chromatographic information query result. In practice, the executing body may perform intersection inversion processing on the chromatographic information query result and the filtered compressed chromatographic information set, so as to obtain each compressed chromatographic information as a non-result compressed chromatographic information set corresponding to the chromatographic key field.

Optionally, the above-mentioned no-result compressed chromatographic information set is stored.

In some embodiments, the execution body may store the set of non-result compression chromatography information. For example, the execution body may add each of the sets of the non-result compressed chromatography information to a stored set of the non-result compressed chromatography information corresponding to the key field of the chromatography to store the set of the non-result compressed chromatography information.

The above related matters serve as an invention point of the present disclosure, and solve the second technical problem mentioned in the background art, namely that the waste of the storage space is easy to be caused. Factors that easily cause waste of storage space are often as follows: when the chromatographic test data volume is large, the query efficiency is low, and more front indexes need to be established. If the above factors are solved, the effect of reducing the waste of storage resources can be achieved. To achieve this, first, it is determined whether the received chromatographic information query request contains a chromatographic key field. And secondly, responding to the fact that the chromatographic information inquiry request contains chromatographic key fields, and acquiring a compressed chromatographic information set corresponding to the chromatographic inquiry conditions according to the chromatographic inquiry conditions corresponding to the chromatographic information inquiry request. Thus, the compressed chromatographic information set can be screened out in advance when the chromatographic information inquiry request contains a chromatographic key field. Then, in response to determining that there is prestored no-result compressed chromatography information corresponding to the chromatography key field, the compressed chromatography information set is filtered according to the prestored no-result compressed chromatography information corresponding to the chromatography key field. Thus, the pre-screened compressed chromatographic information set can be filtered through pre-stored non-result compressed chromatographic information with no result queried according to the chromatographic key field, so as to filter out the compressed chromatographic information which is the same as the non-result compressed chromatographic information of the chromatographic key field in the compressed chromatographic information set. And then, according to the field query conditions corresponding to the chromatographic key fields, selecting each piece of compressed chromatographic information meeting the field query conditions from the filtered compressed chromatographic information set as a chromatographic information query result. Thus, each piece of compressed chromatographic information satisfying the field query condition can be screened from the filtered compressed chromatographic information set as a chromatographic information query result. And finally, sending the chromatographic information inquiry result to an inquiry terminal corresponding to the chromatographic information inquiry request. Thus, the queried chromatographic information query result can be returned to the request end. And when each piece of compressed chromatographic information meeting the field query conditions is screened, the compressed chromatographic information set is filtered in advance through the stored non-result compressed chromatographic information corresponding to the chromatographic key fields, so that the query scanning time is shortened, and the query efficiency is improved. And the query is not performed in a reverse index mode, so that a large number of front indexes are not required to be established, and the storage space and the computing resource are saved. Therefore, the chromatographic key field query efficiency is improved, and the storage space is saved.

With further reference to fig. 2, as an implementation of the method shown in the above figures, the present disclosure provides embodiments of a chromatography detection data interaction device, which correspond to those method embodiments shown in fig. 1, which may find particular application in various electronic devices.

As shown in fig. 2, the chromatographic detection data interaction device 200 of some embodiments includes: an acquisition unit 201, an analysis unit 202, a first determination unit 203, a marking unit 204, a second determination unit 205, a first storage unit 206, and a second storage unit 207. Wherein the obtaining unit 201 is configured to obtain a chromatographic information set generated by a chromatograph, wherein the chromatographic information in the chromatographic information set includes: chromatograph equipment information, environmental parameter information, and chromatographic information, the chromatographic information including a plurality of pieces of chromatographic data; an analysis unit 202 configured to perform the following processing steps for each of the above-described sets of chromatographic information: performing principal component analysis processing on the chromatographic analysis information included in the chromatographic information to generate chromatographic principal component analysis information, wherein the chromatographic principal component analysis information includes a plurality of chromatographic characteristic information; determining a reference chromatographic characteristic information table corresponding to chromatograph equipment information included in the chromatographic information; detecting the chromatographic principal component analysis information according to the reference chromatographic characteristic information table to generate a detection result; a first determining unit 203 configured to determine each piece of the chromatographic information whose detection result characterizes the abnormality as an abnormal chromatographic information group, and each piece of the chromatographic information whose detection result characterizes the abnormality as a normal chromatographic information group; a marking unit 204 configured to mark each piece of abnormal chromatographic information in the abnormal chromatographic information group according to each detection result corresponding to the abnormal chromatographic information group, so as to generate abnormal mark chromatographic information, and obtain an abnormal mark chromatographic information group; a second determining unit 205 configured to determine abnormal chromatographic information buffer information and normal chromatographic information buffer information in response to receiving the information storage instruction; a first storage unit 206 configured to perform locking processing on an anomaly cache node corresponding to the anomaly chromatographic information cache information, and store the anomaly flag chromatographic information set in the anomaly cache node in response to determining that the locking of the anomaly cache node is successful; and a second storage unit 207 configured to perform locking processing on a normal cache node corresponding to the normal chromatographic information cache information, and store the normal chromatographic information group in the normal cache node in response to determining that the locking of the normal cache node is successful.

It will be appreciated that the elements described in the chromatographic detection data interaction device 200 correspond to the various steps in the method described with reference to fig. 1. Thus, the operations, features and advantages described above with respect to the method are equally applicable to the chromatographic detection data interaction device 200 and the units contained therein, and are not described herein.

Referring now to fig. 3, a schematic diagram of an electronic device (e.g., server) 300 suitable for use in implementing some embodiments of the present disclosure is shown. The electronic devices in some embodiments of the present disclosure may include, but are not limited to, mobile terminals such as mobile phones, notebook computers, digital broadcast receivers, PDAs (personal digital assistants), PADs (tablet computers), PMPs (portable multimedia players), car terminals (e.g., car navigation terminals), and the like, as well as stationary terminals such as digital TVs, desktop computers, and the like. The electronic device shown in fig. 3 is merely an example and should not impose any limitations on the functionality and scope of use of embodiments of the present disclosure.

As shown in fig. 3, the electronic device 300 may include a processing means (e.g., a central processing unit, a graphics processor, etc.) 301 that may perform various suitable actions and processes in accordance with a program stored in a Read Only Memory (ROM) 302 or a program loaded from a storage means 308 into a Random Access Memory (RAM) 303. In the RAM 303, various programs and data required for the operation of the electronic apparatus 300 are also stored. The processing device 301, the ROM302, and the RAM 303 are connected to each other via a bus 304. An input/output (I/O) interface 305 is also connected to bus 304.

In general, the following devices may be connected to the I/O interface 305: input devices 306 including, for example, a touch screen, touchpad, keyboard, mouse, camera, microphone, accelerometer, gyroscope, etc.; an output device 307 including, for example, a Liquid Crystal Display (LCD), a speaker, a vibrator, and the like; storage 308 including, for example, magnetic tape, hard disk, etc.; and communication means 309. The communication means 309 may allow the electronic device 300 to communicate with other devices wirelessly or by wire to exchange data. While fig. 3 shows an electronic device 300 having various means, it is to be understood that not all of the illustrated means are required to be implemented or provided. More or fewer devices may be implemented or provided instead. Each block shown in fig. 3 may represent one device or a plurality of devices as needed.

In particular, according to some embodiments of the present disclosure, the processes described above with reference to flowcharts may be implemented as computer software programs. For example, some embodiments of the present disclosure include a computer program product comprising a computer program embodied on a computer readable medium, the computer program comprising program code for performing the method shown in the flow chart. In such embodiments, the computer program may be downloaded and installed from a network via communications device 309, or from storage device 308, or from ROM 302. The above-described functions defined in the methods of some embodiments of the present disclosure are performed when the computer program is executed by the processing means 301.

It should be noted that, the computer readable medium described in some embodiments of the present disclosure may be a computer readable signal medium or a computer readable storage medium, or any combination of the two. The computer readable storage medium can be, for example, but not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or a combination of any of the foregoing. More specific examples of the computer-readable storage medium may include, but are not limited to: an electrical connection having one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing. In some embodiments of the present disclosure, a computer readable storage medium may be any tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device. In some embodiments of the present disclosure, however, the computer-readable signal medium may comprise a data signal propagated in baseband or as part of a carrier wave, with the computer-readable program code embodied therein. Such a propagated data signal may take any of a variety of forms, including, but not limited to, electro-magnetic, optical, or any suitable combination of the foregoing. A computer readable signal medium may also be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device. Program code embodied on a computer readable medium may be transmitted using any appropriate medium, including but not limited to: electrical wires, fiber optic cables, RF (radio frequency), and the like, or any suitable combination of the foregoing.

In some implementations, the clients, servers may communicate using any currently known or future developed network protocol, such as HTTP (HyperText Transfer Protocol ), and may be interconnected with any form or medium of digital data communication (e.g., a communication network). Examples of communication networks include a local area network ("LAN"), a wide area network ("WAN"), the internet (e.g., the internet), and peer-to-peer networks (e.g., ad hoc peer-to-peer networks), as well as any currently known or future developed networks.

The computer readable medium may be contained in the electronic device; or may exist alone without being incorporated into the electronic device. The computer readable medium carries one or more programs which, when executed by the electronic device, cause the electronic device to: acquiring a chromatographic information set generated by a chromatograph, wherein the chromatographic information in the chromatographic information set comprises: chromatograph equipment information, environmental parameter information, and chromatographic information, the chromatographic information including a plurality of pieces of chromatographic data; for each of the above sets of chromatographic information, the following processing steps are performed: performing principal component analysis processing on the chromatographic analysis information included in the chromatographic information to generate chromatographic principal component analysis information, wherein the chromatographic principal component analysis information includes a plurality of chromatographic characteristic information; determining a reference chromatographic characteristic information table corresponding to chromatograph equipment information included in the chromatographic information; detecting the chromatographic principal component analysis information according to the reference chromatographic characteristic information table to generate a detection result; determining each chromatographic information of which the detection result represents abnormality as an abnormal chromatographic information group, and determining each chromatographic information of which the detection result represents normal as a normal chromatographic information group; marking each piece of abnormal chromatographic information in the abnormal chromatographic information group according to each detection result corresponding to the abnormal chromatographic information group so as to generate abnormal marked chromatographic information, and obtaining the abnormal marked chromatographic information group; in response to receiving the information storage instruction, determining abnormal chromatographic information cache information and normal chromatographic information cache information; locking the abnormal cache node corresponding to the abnormal chromatographic information cache information, and storing the abnormal marking chromatographic information set into the abnormal cache node in response to determining that the abnormal cache node is successfully locked; and performing locking processing on a normal cache node corresponding to the normal chromatographic information cache information, and storing the normal chromatographic information set in the normal cache node in response to determining that the normal cache node is successfully locked.

Computer program code for carrying out operations for some embodiments of the present disclosure may be written in one or more programming languages, including an object oriented programming language such as Java, smalltalk, C ++ and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any kind of network, including a Local Area Network (LAN) or a Wide Area Network (WAN), or may be connected to an external computer (for example, through the Internet using an Internet service provider).

The flowcharts and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to various embodiments of the present disclosure. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of code, which comprises one or more executable instructions for implementing the specified logical function(s). It should also be noted that, in some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems which perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.

The units described in some embodiments of the present disclosure may be implemented by means of software, or may be implemented by means of hardware. The described units may also be provided in a processor, for example, described as: a processor includes an acquisition unit, an analysis unit, a first determination unit, a marking unit, a second determination unit, a first storage unit, and a second storage unit. The names of these units do not constitute a limitation of the unit itself in some cases, and for example, the second determination unit may also be described as "a unit that determines the abnormal color spectrum information buffer information and the normal color spectrum information buffer information in response to receiving the information storage instruction".

The functions described above herein may be performed, at least in part, by one or more hardware logic components. For example, without limitation, exemplary types of hardware logic components that may be used include: a Field Programmable Gate Array (FPGA), an Application Specific Integrated Circuit (ASIC), an Application Specific Standard Product (ASSP), a system on a chip (SOC), a Complex Programmable Logic Device (CPLD), and the like.

The foregoing description is only of the preferred embodiments of the present disclosure and description of the principles of the technology being employed. It will be appreciated by those skilled in the art that the scope of the invention in the embodiments of the present disclosure is not limited to the specific combination of the above technical features, but encompasses other technical features formed by any combination of the above technical features or their equivalents without departing from the spirit of the invention. Such as the above-described features, are mutually substituted with (but not limited to) the features having similar functions disclosed in the embodiments of the present disclosure.

Claims

1. A chromatography detection data interaction method, comprising:

acquiring a chromatograph-generated chromatograph information set, wherein the chromatograph information in the chromatograph information set includes: chromatograph equipment information, environmental parameter information, and chromatographic information, the chromatographic information including a plurality of pieces of chromatographic data;

for each of the set of chromatographic information, performing the following processing steps:

performing principal component analysis processing on chromatographic analysis information included in the chromatographic information to generate chromatographic principal component analysis information, wherein the chromatographic principal component analysis information includes a plurality of chromatographic characteristic information;

determining a reference chromatographic characteristic information table corresponding to chromatograph equipment information included in the chromatographic information;

detecting the chromatographic principal component analysis information according to the reference chromatographic characteristic information table to generate a detection result;

determining each chromatographic information of which the detection result represents abnormality as an abnormal chromatographic information group, and determining each chromatographic information of which the detection result represents normal as a normal chromatographic information group;

marking each piece of abnormal chromatographic information in the abnormal chromatographic information group according to each detection result corresponding to the abnormal chromatographic information group to generate abnormal marked chromatographic information, and obtaining the abnormal marked chromatographic information group, wherein the abnormal marked chromatographic information in the abnormal marked chromatographic information group comprises chromatograph equipment information, and the chromatograph equipment information comprises: chromatograph equipment number;

In response to receiving the information storage instruction, determining abnormal chromatographic information cache information and normal chromatographic information cache information;

locking the abnormal cache node corresponding to the abnormal chromatographic information cache information, and storing the abnormal marking chromatographic information group into the abnormal cache node in response to determining that the abnormal cache node is successfully locked;

performing locking processing on a normal cache node corresponding to the normal chromatographic information cache information, and storing the normal chromatographic information group into the normal cache node in response to determining that the normal cache node is successfully locked;

determining whether the received chromatographic information query request contains a chromatographic key field;

responding to the fact that the chromatographic information inquiry request contains a chromatographic key field, and acquiring a compressed chromatographic information set corresponding to chromatographic inquiry conditions according to the chromatographic inquiry conditions corresponding to the chromatographic information inquiry request;

in response to determining that there is prestored no-result compressed chromatography information corresponding to the chromatography key field, filtering the compressed chromatography information set according to the prestored no-result compressed chromatography information corresponding to the chromatography key field;

According to the field query conditions corresponding to the chromatographic key fields, selecting each piece of compressed chromatographic information meeting the field query conditions from the filtered compressed chromatographic information set as a chromatographic information query result;

sending the chromatographic information inquiry result to an inquiry terminal corresponding to the chromatographic information inquiry request;

generating a no-result compressed chromatographic information set corresponding to the chromatographic key field according to the chromatographic information query result;

storing the set of non-result compression chromatographic information;

wherein the storing the anomaly signature chromatographic information set into the anomaly cache node includes:

determining whether a chromatograph equipment number corresponding to the abnormal mark chromatograph information group exists in a preset chromatograph equipment number group;

in response to determining that the chromatograph equipment numbers corresponding to the abnormal mark chromatographic information group exist in the chromatograph equipment number group, clustering the abnormal mark chromatographic information group according to a preset capacity threshold value to obtain an abnormal mark chromatographic information set group;

for each anomaly flag chromatographic information set in the anomaly flag chromatographic information set group, performing the following storing step:

Storing the anomaly signature chromatographic information set in a first chromatographic information cache node of the anomaly cache node in response to determining that an information capacity corresponding to the anomaly signature chromatographic information set is greater than a target capacity threshold;

storing the anomaly signature chromatographic information set in a second chromatographic information cache node of the anomaly cache node in response to determining that an information capacity corresponding to the anomaly signature chromatographic information set is less than or equal to the target capacity threshold;

the clustering processing is performed on the abnormal mark chromatographic information set according to a preset capacity threshold value to obtain an abnormal mark chromatographic information set, and the clustering processing comprises the following steps:

determining the data capacity of each piece of abnormal mark chromatographic information in the abnormal mark chromatographic information group to obtain a data capacity group;

and in response to determining that the sum of the data capacities in the data capacity group is greater than the capacity threshold, clustering the abnormal mark chromatographic information group according to the data capacity group to obtain an abnormal mark chromatographic information set group, wherein the sum of the data capacities corresponding to the abnormal mark chromatographic information set group is smaller than or equal to the capacity threshold.

2. The method of claim 1, wherein the method further comprises:

Generating storage failure information in response to determining that the group of anomaly flag chromatographic information fails to store;

determining the storage failure times corresponding to the abnormal cache nodes in a preset time period;

in response to determining that the number of storage failures is less than or equal to a preset threshold, storing the anomaly signature chromatographic information set into the anomaly cache node again;

and in response to determining that the abnormal mark chromatographic information set fails to be stored again, storing the abnormal mark chromatographic information set into a preset alternative cache node.

3. A chromatography detection data interaction device, comprising:

an acquisition unit configured to acquire a set of chromatographic information generated by a chromatograph, wherein the chromatographic information in the set of chromatographic information includes: chromatograph equipment information, environmental parameter information, and chromatographic information, the chromatographic information including a plurality of pieces of chromatographic data;

an analysis unit configured to perform, for each of the set of chromatographic information, the following processing steps: performing principal component analysis processing on chromatographic analysis information included in the chromatographic information to generate chromatographic principal component analysis information, wherein the chromatographic principal component analysis information includes a plurality of chromatographic characteristic information; determining a reference chromatographic characteristic information table corresponding to chromatograph equipment information included in the chromatographic information; detecting the chromatographic principal component analysis information according to the reference chromatographic characteristic information table to generate a detection result;

A first determination unit configured to determine, as an abnormal chromatographic information group, respective chromatographic information whose detection result characterizes the abnormality, and determine, as a normal chromatographic information group, respective chromatographic information whose detection result characterizes the abnormality;

a marking unit configured to mark each piece of abnormal chromatographic information in the abnormal chromatographic information group according to each detection result corresponding to the abnormal chromatographic information group, so as to generate abnormal mark chromatographic information, and obtain an abnormal mark chromatographic information group, wherein the abnormal mark chromatographic information in the abnormal mark chromatographic information group comprises chromatograph equipment information, and the chromatograph equipment information comprises: chromatograph equipment number;

a second determination unit configured to determine abnormal chromatographic information buffer information and normal chromatographic information buffer information in response to receiving the information storage instruction;

a first storage unit configured to perform locking processing on an abnormal cache node corresponding to the abnormal chromatographic information cache information, and store the abnormal flag chromatographic information set into the abnormal cache node in response to determining that the locking of the abnormal cache node is successful; the first storage unit is further configured to:

in response to determining that the sum of all data capacities in the data capacity group is greater than the capacity threshold, clustering the abnormal mark chromatographic information group according to the data capacity group to obtain an abnormal mark chromatographic information set group, wherein the sum of all data capacities corresponding to the abnormal mark chromatographic information set group is smaller than or equal to the capacity threshold;

the second storage unit is configured to lock a normal cache node corresponding to the normal chromatographic information cache information and store the normal chromatographic information group into the normal cache node in response to determining that the normal cache node is successfully locked;

a third determining unit configured to determine whether the received chromatographic information inquiry request contains a chromatographic key field;

a second obtaining unit configured to obtain, in response to determining that the chromatographic information query request includes a chromatographic key field, a compressed chromatographic information set corresponding to a chromatographic query condition corresponding to the chromatographic information query request according to the chromatographic query condition;

A filtering unit configured to filter the compressed chromatography information set according to prestored non-result compressed chromatography information corresponding to the chromatography key field in response to determining that there is prestored non-result compressed chromatography information corresponding to the chromatography key field;

a selecting unit configured to select, from the filtered compressed chromatographic information set, each compressed chromatographic information satisfying the field query condition as a chromatographic information query result according to a field query condition corresponding to the chromatographic key field;

a sending unit configured to send the chromatographic information inquiry result to an inquiry terminal corresponding to the chromatographic information inquiry request;

a generating unit configured to generate a no-result compressed chromatographic information set corresponding to the chromatographic key field according to the chromatographic information query result;

and a third storage unit configured to store the no-result compressed chromatography information set.

4. An electronic device, comprising:

one or more processors;

a storage device having one or more programs stored thereon;

when executed by the one or more processors, causes the one or more processors to implement the method of any of claims 1-2.

5. A computer readable medium having stored thereon a computer program, wherein the program when executed by a processor implements the method of any of claims 1-2.