CN115814167A - Ureteral stent, preparation raw material for preparing ureteral stent and preparation method - Google Patents
Ureteral stent, preparation raw material for preparing ureteral stent and preparation method Download PDFInfo
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- CN115814167A CN115814167A CN202211717794.4A CN202211717794A CN115814167A CN 115814167 A CN115814167 A CN 115814167A CN 202211717794 A CN202211717794 A CN 202211717794A CN 115814167 A CN115814167 A CN 115814167A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 106
- 239000002994 raw material Substances 0.000 title claims abstract description 31
- 239000000463 material Substances 0.000 claims abstract description 104
- 239000000843 powder Substances 0.000 claims abstract description 28
- 235000011837 pasties Nutrition 0.000 claims abstract description 26
- 239000003814 drug Substances 0.000 claims abstract description 24
- 239000007788 liquid Substances 0.000 claims abstract description 21
- 229920000742 Cotton Polymers 0.000 claims abstract description 19
- 241000209094 Oryza Species 0.000 claims abstract description 18
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 18
- 235000009566 rice Nutrition 0.000 claims abstract description 18
- 238000000227 grinding Methods 0.000 claims abstract description 17
- 238000002156 mixing Methods 0.000 claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 10
- 238000002791 soaking Methods 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 4
- 238000000465 moulding Methods 0.000 claims description 4
- 230000018044 dehydration Effects 0.000 claims description 3
- 238000006297 dehydration reaction Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 210000000626 ureter Anatomy 0.000 description 9
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 235000008216 herbs Nutrition 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- 238000002513 implantation Methods 0.000 description 3
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 230000036262 stenosis Effects 0.000 description 2
- 208000037804 stenosis Diseases 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- 206010007026 Calculus urethral Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010065584 Urethral stenosis Diseases 0.000 description 1
- 208000009911 Urinary Calculi Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 201000009160 urethral calculus Diseases 0.000 description 1
- 201000001988 urethral stricture Diseases 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
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Abstract
The invention provides a ureteral stent which is low in manufacturing cost, environment-friendly, renewable and capable of directly acting on a human body focus, as well as a preparation raw material and a preparation method for the ureteral stent, wherein the preparation raw material comprises genuine medicinal materials (traditional Chinese medicinal materials), glutinous rice and cotton or silk, the genuine medicinal materials account for 60-80% by mass, the glutinous rice accounts for 15-25% by mass, and the cotton or silk accounts for 5-15% by mass. The preparation method comprises the following steps: grinding, namely grinding the preparation raw materials into fine powder to obtain a fine powder preparation material; decocting, namely putting the genuine medicinal materials into water for decocting, and separating residues after decocting to obtain a medicinal liquid preparation material; mixing paste, namely adding the liquid medicine preparation material into the fine powder preparation material, and stirring and mixing the paste to obtain a pasty preparation material; and (3) preparing a tube, namely preparing the pasty preparation material into a tubular structure. The ureteral stent is prepared from the preparation raw materials by the preparation method.
Description
[ technical field ] A method for producing a semiconductor device
The invention relates to a ureteral stent, a preparation raw material for preparing the ureteral stent and a preparation method of the ureteral stent.
[ background of the invention ]
Urinary system operations (such as operations of urethral stricture, calculus and lithotripsy, operations of kidney, ureter, bladder and the like) generally require the placement of ureteral stents. The ureteral stent is clinically placed in a kidney cavity, a ureteral cavity and a bladder cavity, urine is drained from a kidney to the bladder, the ureteral recovery and calculus discharge are promoted, the stenosis formation is prevented, the ureteral stent is supported to prevent stenosis, the intrarenal pressure is reduced, the kidney blood supply is facilitated, and the ureteral stent is supported to prevent tumors from crushing the ureteral.
Ureteral stents are common medical devices for urology surgery, and have definite clinical efficacy, but have a series of complications or defects, including bleeding from the wound of the catheter placement, infection, formation of the stent skin, discomfort after the catheter placement, and urinary reflux of the vesicoureteral. There are roughly two major types of ureteral stents currently in use on the market: 1. the metal stent is expensive because of its high manufacturing cost and its monopoly in technology from abroad, and is not suitable for a long time (foreign body feeling) after being placed in a tube. 2. The raw materials of the bracket made of plastic (high polymer material, which is not environment-friendly) and 65% barium sulfate (barium sulfate is used as a developer, so that the bracket can be developed under X-ray and other imaging equipment) are imported, the price is high, the price of one pack of twenty-five kilograms is 18600 yuan, and the technology of the product is monopolized abroad, and in addition, in recent years, the material is in short supply, and the production cost is increased greatly.
Therefore, most ureteral stents used in the current market are made of metal or plastic materials, the problem of surface crystallization is easy to occur, the technology is monopolized abroad, and the price is very high.
[ summary of the invention ]
The invention aims to provide a ureteral stent which has low manufacturing cost, is environment-friendly and renewable and can directly act on a focus of a human body, and a preparation raw material and a preparation method for preparing the ureteral stent.
The purpose of the invention is realized as follows:
a raw material for preparing a ureteral stent comprises genuine medicinal materials (traditional Chinese medicinal materials), sticky rice and cotton or silk, wherein the genuine medicinal materials account for 60-80% by mass, the sticky rice accounts for 15-25% by mass, and the cotton or silk accounts for 5-15% by mass.
A method for preparing a ureteral stent, comprising the steps of: grinding, namely grinding the preparation raw materials into fine powder to obtain a fine powder preparation material; decocting, namely putting the genuine medicinal materials into water for decocting, and separating residues after decocting to obtain a liquid medicine preparation material; mixing paste, namely adding the liquid medicine preparation material into the fine powder preparation material, and stirring and mixing the paste to obtain a pasty preparation material; and (3) preparing a tube, namely preparing the pasty preparation material into a tubular structure.
The preparation method for preparing the ureteral stent comprises the following steps: and (3) molding a pipe, namely putting a mold core into a mold, adding the pasty preparation material into the mold, and carrying out mold closing, pressurization, heating, dehydration, demolding and core pulling to obtain a molded tubular structure.
The preparation method for preparing the ureteral stent is characterized in that the tube preparation step comprises the following steps: soaking and tubing, inserting a mold core into the pasty preparation material, adsorbing the pasty preparation material on the mold core, then drawing out the mold core adsorbed with the pasty preparation material, drying, and finally drawing core to obtain a formed tubular structure.
In the above preparation method for preparing a ureteral stent, in the grinding step, the mesh number of the fine powder preparation material is more than 200 meshes.
In the preparation method for preparing the ureteral stent, in the paste mixing step, the ratio of the liquid medicine preparation material to the fine powder preparation material is not less than 20%.
The ureteral stent is prepared from the raw materials by the preparation method.
Compared with the prior art, the invention mainly has the following technical characteristics:
1. the raw materials of the invention are prepared from genuine medicinal materials (traditional Chinese medicinal materials), have good biocompatibility, and can be prepared without plastic and metal, and the genuine medicinal materials can be developed under X-ray and other imaging equipment, and barium sulfate and other developers are not required to be added, so the invention has low manufacturing cost, and in addition, the prepared raw materials can be directly taken from nature, and are environment-friendly and renewable.
2. The ureteral stent of the invention not only can play a basic supporting role of the ureteral stent, but also can directly act on the focus of a human body by using genuine medicinal materials, thereby achieving a considerable treatment effect.
3. The invention contains glutinous rice, thereby increasing the strength and toughness of the ureteral stent and ensuring that the ureteral stent has enough compression strength and tensile strength.
4. The invention contains cotton (or silk), so that the ureteral stent has certain toxicity resistance.
5. The invention can be prepared by four steps of grinding, decocting, mixing paste and preparing tube, and the process is simple and easy to prepare.
6. The mesh number of the fine powder preparation material is larger than 200 meshes, so that the smoothness of the ureteral stent is ensured (if the mesh number of the fine powder preparation material is smaller than 200 meshes, the prepared product is rough).
7. The ratio of the liquid medicine preparation material to the fine powder preparation material is moderate, so that the softness of the ureteral stent is ensured, and the ureteral stent is not hard.
8. The traditional Chinese medicine has long history and long source, and the value thereof is proved by clinical practice.
The main material of the ureter bracket is genuine medicinal materials, and the ureter bracket has good material safety and can not generate substances which are toxic and harmful to human bodies. The tissue compatibility is good, the mechanical property is matched with the implanted tissue, and after the implant is implanted into a human body, the side effect is small, the discomfort of a patient cannot be caused, the foreign body sensation is small, the pain is avoided, and the normal physiological function is not influenced. In the process of implantation, because the traditional Chinese medicine components are released at any time, stones capable of being stuck to the surface of the stent are few, therefore, urinary stone particles are difficult to form on the surface of the stent, the burden of a patient is reduced, and the life quality is improved, so that compared with a plastic stent and a metal stent, the problem of surface crystallization does not exist, dirt can be prevented from being adhered, and stones are not generated. The stent can continuously keep the same degree of developing effect in the long-term implantation process.
9. The glutinous rice and the cotton (or the silk) in the raw materials of the ureteral stent belong to genuine medicinal materials, so the raw materials are all the genuine medicinal materials, and the ureteral stent is low in manufacturing cost, environment-friendly and renewable.
[ detailed description ] embodiments
Example I
The preparation raw material for preparing the ureter bracket comprises genuine medicinal materials, sticky rice and cotton, wherein the genuine medicinal materials account for 70% by mass, the sticky rice accounts for 20% by mass, and the cotton accounts for 10% by mass.
A preparation method for preparing a ureteral stent comprises the following steps: a: grinding, namely grinding the preparation raw materials into fine powder to obtain a fine powder preparation material with the mesh number of 800; b: decocting, namely putting the genuine medicinal materials into water for decocting, and separating residues after decocting to obtain a medicinal liquid preparation material; c: mixing paste, namely adding the liquid medicine preparation material into a fine powder preparation material (the proportion of the liquid medicine preparation material to the fine powder preparation material is 20%, if the proportion is less than 20%, the situation that part of the fine powder preparation material cannot be dissolved and mixed paste can occur), and stirring and mixing paste to obtain a paste preparation material; d: and (4) preparing a tube, namely preparing the pasty preparation material into a tubular structure. Wherein, the step of tubing comprises the following steps: e: and (3) molding a pipe, namely putting a mold core into a mold, adding a pasty preparation material into the mold, and carrying out mold closing, pressurization, heating, dehydration, demolding and core pulling to obtain a molded tubular structure.
The ureteral stent prepared by the preparation raw materials of the embodiment and the preparation method contains 70% of genuine medicinal materials, 20% of glutinous rice and 10% of cotton, and is optimal in combination of pharmacological efficacy, strength, toughness and toxicity resistance. The mesh number of the fine powder preparation material is 800 meshes, which is easily achieved by the existing grinding technology and can ensure that the traditional Chinese medicine ureter stent has good smoothness, if the mesh number is more than 800 meshes, the traditional Chinese medicine ureter stent is difficult to achieve by the existing grinding technology, and if the mesh number is less than 200 meshes, the prepared traditional Chinese medicine ureter stent is rough and is not suitable for implantation.
Example II
The preparation raw material for preparing the ureter bracket comprises genuine medicinal materials, glutinous rice and cotton, wherein the genuine medicinal materials account for 80 mass percent, the glutinous rice accounts for 15 mass percent, and the cotton accounts for 5 mass percent.
A preparation method for preparing a ureteral stent comprises the following steps: a: grinding, namely grinding the preparation raw materials into fine powder to obtain a fine powder preparation material with the mesh number of 800; b: decocting, namely putting the genuine medicinal materials into water for decocting, and separating residues after decocting to obtain a medicinal liquid preparation material; c: mixing paste, namely adding the liquid medicine preparation material into the fine powder preparation material, and stirring and mixing the paste to obtain a pasty preparation material; d: and (4) preparing a pipe, namely preparing the pasty preparation material into a tubular structure. Wherein, the step of making the tube comprises the following steps: f: soaking and tubing, inserting a mold core into the pasty preparation material, adsorbing the pasty preparation material on the mold core, then drawing out the mold core adsorbed with the pasty preparation material, drying, and finally drawing core to obtain a formed tubular structure.
The ureteral stent prepared by the preparation raw materials of the embodiment and the preparation method comprises 80% of genuine medicinal materials, 15% of glutinous rice and 5% of cotton, and compared with the ureteral stent of the embodiment I, the ureteral stent has the advantages that the pharmacological efficacy is enhanced, but the strength, the toughness and the antitoxicity are reduced, and the ureteral stent only meets the requirements of the lowest strength, the toughness and the antitoxicity. In addition, compared with example I, this embodiment is also different in the tube-making step, the tube-making step of this embodiment adopts the soaking tube-making method, and example I adopts the tube-making method similar to injection molding, but it should be noted that both the tube-making steps of example I and example II can be well molded to obtain the traditional Chinese medicine ureteral stent, so example II can also adopt the molding tube-making step of example I to replace the soaking tube-making step.
Example III
The preparation raw material for preparing the ureter bracket comprises genuine medicinal materials, glutinous rice and cotton, wherein the genuine medicinal materials account for 60 mass percent, the glutinous rice accounts for 25 mass percent, and the cotton accounts for 15 mass percent.
A preparation method for preparing a ureteral stent comprises the following steps: a: grinding, namely grinding the preparation raw materials into fine powder to obtain a fine powder preparation material with the mesh number of 800; b: decocting, namely putting the genuine medicinal materials into water for decocting, and separating residues after decocting to obtain a liquid medicine preparation material; c: mixing paste, namely adding the liquid medicine preparation material into the fine powder preparation material, and stirring and mixing the paste to obtain a pasty preparation material; d: and (4) preparing a tube, namely preparing the pasty preparation material into a tubular structure. Wherein, the step of making the tube comprises the following steps: f: soaking and tubing, inserting a mold core into the pasty preparation material, adsorbing the pasty preparation material on the mold core, then drawing out the mold core adsorbed with the pasty preparation material, drying, and finally drawing core to obtain a formed tubular structure.
The ureteral stent prepared by the preparation raw materials of the embodiment and the preparation method comprises 60% of genuine medicinal materials, 25% of glutinous rice and 15% of cotton, and compared with the ureteral stent of the embodiment II, the ureteral stent has the advantages of enhanced strength, toughness and toxicity resistance, but weakened pharmacological efficacy and only meets the requirement of the lowest pharmacological efficacy. Similarly, the plastic tube-making step of embodiment I can be used to replace the soaking tube-making step.
Examples IV to VI
Examples IV, V and VI correspond to examples I, II and III respectively, and the difference is only that silk is used for replacing cotton in the raw materials for preparing the raw materials for the examples I, II and III, and the silk and the cotton can enable the prepared ureteral stent to have certain toxicity resistance, so that the effects of the examples IV, V and VI are basically the same as those of the examples I, II and III.
Preferably, in the decocting step of any one of embodiments I to VI, the genuine herbs (chinese herbs) are decocted twice according to a chinese herbal medicine decocting method, the genuine herbs are soaked in cold water for half an hour before decocting, then boiled with strong fire, and then boiled with slow fire for about 30 minutes, after separating the dregs, a first liquid medicine (chinese herb water) and a dregs separating material are obtained, then water is added to the dregs separating material, the decocting step is repeated and the genuine herbs are decocted again to obtain a second liquid medicine (chinese herb water), and the first liquid medicine and the second liquid medicine are mixed together to obtain the liquid medicine preparation material.
Claims (8)
1. A preparation raw material for preparing a ureteral stent is characterized by comprising genuine medicinal materials, sticky rice and cotton, wherein the genuine medicinal materials account for 60-80% by mass, the sticky rice accounts for 15-25% by mass, and the cotton accounts for 5-15% by mass.
2. A preparation raw material for preparing a ureteral stent is characterized by comprising genuine medicinal materials, 15-25% of glutinous rice and 5-15% of silk, wherein the genuine medicinal materials account for 60-80% by mass, and the silk is accounted for by 15-25% by mass.
3. A method for preparing a ureteral stent, characterized by comprising the steps of:
a: grinding, namely grinding the preparation raw materials into fine powder to obtain a fine powder preparation material;
b: decocting, namely putting the genuine medicinal materials into water for decocting, and separating residues after decocting to obtain a liquid medicine preparation material;
c: mixing paste, namely adding the liquid medicine preparation material into the fine powder preparation material, and stirring and mixing the paste to obtain a pasty preparation material;
d: and (3) preparing a tube, namely preparing the pasty preparation material into a tubular structure.
4. A method for preparing a ureteral stent according to claim 3, characterized in that said tubing step comprises the following steps:
e: and (3) molding a pipe, namely putting a mold core into a mold, adding the pasty preparation material into the mold, and carrying out mold closing, pressurization, heating, dehydration, demolding and core pulling to obtain a molded tubular structure.
5. A method for preparing a ureteral stent according to claim 3, characterized in that said tubing step comprises the following steps:
f: soaking and tubing, inserting a mold core into the pasty preparation material, adsorbing the pasty preparation material on the mold core, then drawing out the mold core adsorbed with the pasty preparation material, drying, and finally drawing core to obtain a formed tubular structure.
6. The manufacturing method for manufacturing a ureteral stent according to claim 4 or 5, characterized in that in the grinding step, the mesh number of the fine powder manufacturing material is more than 200 meshes.
7. The preparation method for preparing the ureteral stent according to claim 6, wherein in the paste mixing step, the ratio of the liquid medicine preparation material to the fine powder preparation material is not less than 20%.
8. A ureteral stent, characterized by being produced using the production raw material described in claim 1 or 2 and by the production method described in any one of claims 3 to 7.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211717794.4A CN115814167A (en) | 2022-12-30 | 2022-12-30 | Ureteral stent, preparation raw material for preparing ureteral stent and preparation method |
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| CN202211717794.4A CN115814167A (en) | 2022-12-30 | 2022-12-30 | Ureteral stent, preparation raw material for preparing ureteral stent and preparation method |
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| CN115814167A true CN115814167A (en) | 2023-03-21 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101588795B1 (en) * | 2014-10-17 | 2016-01-26 | 주식회사 금아바이오 | The method of manufacturing for pipe using eco-friendly natural materials |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101588795B1 (en) * | 2014-10-17 | 2016-01-26 | 주식회사 금아바이오 | The method of manufacturing for pipe using eco-friendly natural materials |
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