CN115813792A - Broad spectrum sunscreen compositions - Google Patents
Broad spectrum sunscreen compositions Download PDFInfo
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- CN115813792A CN115813792A CN202211481599.6A CN202211481599A CN115813792A CN 115813792 A CN115813792 A CN 115813792A CN 202211481599 A CN202211481599 A CN 202211481599A CN 115813792 A CN115813792 A CN 115813792A
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- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 211
- 230000000475 sunscreen effect Effects 0.000 title claims abstract description 168
- 239000000203 mixture Substances 0.000 title claims abstract description 90
- XVAMCHGMPYWHNL-UHFFFAOYSA-N bemotrizinol Chemical compound OC1=CC(OCC(CC)CCCC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=NC(C=2C(=CC(OCC(CC)CCCC)=CC=2)O)=N1 XVAMCHGMPYWHNL-UHFFFAOYSA-N 0.000 claims abstract description 30
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000004519 grease Substances 0.000 claims abstract description 20
- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229960001630 diethylamino hydroxybenzoyl hexyl benzoate Drugs 0.000 claims abstract description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 5
- 239000000126 substance Substances 0.000 claims description 20
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 claims description 12
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 10
- 239000006071 cream Substances 0.000 claims description 9
- 239000007921 spray Substances 0.000 claims description 9
- 241000195940 Bryophyta Species 0.000 claims description 5
- 235000011929 mousse Nutrition 0.000 claims description 5
- 239000011787 zinc oxide Substances 0.000 claims description 5
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 4
- PXTQQOLKZBLYDY-UHFFFAOYSA-N bis(2-ethylhexyl) carbonate Chemical compound CCCCC(CC)COC(=O)OCC(CC)CCCC PXTQQOLKZBLYDY-UHFFFAOYSA-N 0.000 claims description 4
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000003921 oil Substances 0.000 description 34
- 239000000047 product Substances 0.000 description 17
- 238000003756 stirring Methods 0.000 description 16
- 238000001816 cooling Methods 0.000 description 15
- 230000037072 sun protection Effects 0.000 description 14
- 239000002537 cosmetic Substances 0.000 description 12
- 238000000034 method Methods 0.000 description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 11
- 239000003925 fat Substances 0.000 description 10
- 238000010521 absorption reaction Methods 0.000 description 9
- 238000009472 formulation Methods 0.000 description 9
- 238000010438 heat treatment Methods 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 7
- -1 diethylaminooxybenzoyl hexyl Chemical group 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 238000012216 screening Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 239000004408 titanium dioxide Substances 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 4
- 230000004224 protection Effects 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 238000011160 research Methods 0.000 description 4
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- UUGLJVMIFJNVFH-UHFFFAOYSA-N Benzoesaeure-n-hexylester Natural products CCCCCCOC(=O)C1=CC=CC=C1 UUGLJVMIFJNVFH-UHFFFAOYSA-N 0.000 description 3
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 description 3
- 239000000443 aerosol Substances 0.000 description 3
- OSORMYZMWHVFOZ-UHFFFAOYSA-N benzoic acid phenethyl ester Natural products C=1C=CC=CC=1C(=O)OCCC1=CC=CC=C1 OSORMYZMWHVFOZ-UHFFFAOYSA-N 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 229940068171 ethyl hexyl salicylate Drugs 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000000265 homogenisation Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- RDOFJDLLWVCMRU-UHFFFAOYSA-N Diisobutyl adipate Chemical compound CC(C)COC(=O)CCCCC(=O)OCC(C)C RDOFJDLLWVCMRU-UHFFFAOYSA-N 0.000 description 2
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000006750 UV protection Effects 0.000 description 2
- UBNYRXMKIIGMKK-RMKNXTFCSA-N amiloxate Chemical compound COC1=CC=C(\C=C\C(=O)OCCC(C)C)C=C1 UBNYRXMKIIGMKK-RMKNXTFCSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
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- 238000000576 coating method Methods 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 229940067572 diethylhexyl adipate Drugs 0.000 description 2
- 229940096810 diethylhexyl sebacate Drugs 0.000 description 2
- VJHINFRRDQUWOJ-UHFFFAOYSA-N dioctyl sebacate Chemical compound CCCCC(CC)COC(=O)CCCCCCCCC(=O)OCC(CC)CCCC VJHINFRRDQUWOJ-UHFFFAOYSA-N 0.000 description 2
- SRVSYCCHRDXMMS-UHFFFAOYSA-N dodecan-5-yl 2-hydroxybenzoate Chemical compound CCCCCCCC(CCCC)OC(=O)C1=CC=CC=C1O SRVSYCCHRDXMMS-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
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- 239000003205 fragrance Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 229960001679 octinoxate Drugs 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000011814 protection agent Substances 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 230000003381 solubilizing effect Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
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- 238000003892 spreading Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- HEOCBCNFKCOKBX-RELGSGGGSA-N (1s,2e,4r)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-3-one Chemical compound C1=CC(C)=CC=C1\C=C/1C(=O)[C@]2(C)CC[C@H]\1C2(C)C HEOCBCNFKCOKBX-RELGSGGGSA-N 0.000 description 1
- TYYHDKOVFSVWON-UHFFFAOYSA-N 2-butyl-2-methoxy-1,3-diphenylpropane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C(OC)(CCCC)C(=O)C1=CC=CC=C1 TYYHDKOVFSVWON-UHFFFAOYSA-N 0.000 description 1
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 1
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 description 1
- 206010063493 Premature ageing Diseases 0.000 description 1
- 208000032038 Premature aging Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 229960004050 aminobenzoic acid Drugs 0.000 description 1
- 229960005193 avobenzone Drugs 0.000 description 1
- 229960004101 bemotrizinol Drugs 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N benzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- SAOKZLXYCUGLFA-UHFFFAOYSA-N bis(2-ethylhexyl) adipate Chemical compound CCCCC(CC)COC(=O)CCCCC(=O)OCC(CC)CCCC SAOKZLXYCUGLFA-UHFFFAOYSA-N 0.000 description 1
- FQUNFJULCYSSOP-UHFFFAOYSA-N bisoctrizole Chemical compound N1=C2C=CC=CC2=NN1C1=CC(C(C)(C)CC(C)(C)C)=CC(CC=2C(=C(C=C(C=2)C(C)(C)CC(C)(C)C)N2N=C3C=CC=CC3=N2)O)=C1O FQUNFJULCYSSOP-UHFFFAOYSA-N 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 229940031769 diisobutyl adipate Drugs 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 231100000507 endocrine disrupting Toxicity 0.000 description 1
- 229960004697 enzacamene Drugs 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229940074047 glyceryl cocoate Drugs 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- YGTXVSJBZAIWJK-UHFFFAOYSA-N hexyl 4-amino-2-benzoyl-5,6-diethyl-3-hydroxybenzoate Chemical compound CCCCCCOC(=O)C1=C(CC)C(CC)=C(N)C(O)=C1C(=O)C1=CC=CC=C1 YGTXVSJBZAIWJK-UHFFFAOYSA-N 0.000 description 1
- 229960004881 homosalate Drugs 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000001282 iso-butane Substances 0.000 description 1
- 229940100554 isononyl isononanoate Drugs 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- ZWLPBLYKEWSWPD-UHFFFAOYSA-N o-toluic acid Chemical compound CC1=CC=CC=C1C(O)=O ZWLPBLYKEWSWPD-UHFFFAOYSA-N 0.000 description 1
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 description 1
- 229960000601 octocrylene Drugs 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
- 229960001173 oxybenzone Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229940098888 phenethyl benzoate Drugs 0.000 description 1
- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 description 1
- 229940033329 phytosphingosine Drugs 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
The present invention provides a safe, simple, stable, broad-spectrum sunscreen composition comprising: a primary sunscreen agent which is a combination of bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, and diethylamino hydroxybenzoyl hexyl benzoate, wherein the weight ratio of bis-ethylhexyloxyphenol methoxyphenyl triazine and ethylhexyl triazone is 0.25 to 1.2, wherein the weight ratio of bis-ethylhexyloxyphenol methoxyphenyl triazine to diethylamino hydroxybenzoyl hexyl benzoate is 0.6 to 1.6; an oil or fat for sunscreen agents, which contains no phenyl group and has a dielectric constant of less than 3; wherein the weight ratio of the grease to the main sunscreen agent in the sunscreen composition is 1.5-4. The invention also provides a safe, simple, stable and broad-spectrum sunscreen product.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to a safe, simple, stable and broad-spectrum sunscreen composition, and relates to a preparation method and application of the sunscreen composition.
Background
Mild sunscreen is a primary consideration in the choice of sunscreen products for both children and adults sensitive in the sunscreen market. The sunscreen products currently on the market include physical sunscreens (i.e. using the inorganic sunscreens titanium dioxide or zinc oxide), chemical sunscreens (i.e. using the organic sunscreens of the sunscreen list) and physicochemical combinations of the three types. Physical sunscreens have a high safety consensus, but have the relative weaknesses of unsatisfactory use experience (difficult coating, false white skin after coating, certain astringent feeling and the like) and difficulty in cleaning, so that chemical sunscreens have considerable advantages in use experience and sunscreen efficiency and cannot be replaced by physical sunscreens.
However, there has been much controversy over the safety and mildness of chemical sunscreens in recent years. The chemical sun-screening agents have a relatively large variety, and in 27 standard sun-screening agents in China, except 2 physical sun-screening agents, the other 25 sun-screening agents belong to chemical sun-screening agents. However, many chemical sunscreens have been increasingly confronted in recent years with human and environmental safety risks and challenges.
Traditionally widely used benzophenone-3, ethylhexyl methoxycinnamate, isoamyl p-methoxycinnamate, homosalate, and 4-methylbenzylidene camphor have all been suspected of presenting potential risks of endocrine disruption. Problems such as skin irritation and high skin permeability are also suspected for octocrylene, ethylhexyl salicylate, PEG-25 p-aminobenzoic acid, and the like. Butyl methoxydibenzoylmethane, which is a few UVA band absorbers, is not safe, but has a problem of unstable illumination, and thus its use is limited. Methylene bis-benzotriazolyl tetramethyl butyl phenol is taken as a macromolecular sun-screening agent with UVA and UVB absorption at the same time, and is not recommended to be used in children products according to the technical guidance principle of children cosmetics in China because of belonging to nano materials.
Throughout the list of standard chemical sunscreens, from the safety and stability points of view, bis-ethylhexyloxyphenol methoxyphenyl triazine (molecular weight 627 dalton), ethylhexyl triazone (molecular weight 822 dalton) and diethylaminooxybenzoyl hexyl benzoate (molecular weight 397 dalton), both of which absorb in the UVA and UVB broad spectrum, are increasingly used due to their higher molecular weight, molecular stability and excellent toxicological data up to now, the rate of use in the market for both adult and child sunscreens rising rapidly in recent years. In particular, according to the Ribes-King's rule on the theory of drug permeation, it is mentioned that drugs with a component of more than 500 daltons are not easily permeated, and from this point of view, the macromolecular bis-ethylhexyloxyphenol methoxyphenyl triazine and ethylhexyl triazone have lower permeation risks. The other liquid type sunscreen agent polysiloxane-15 has a relatively large molecular weight as a polymer, but is not considered as a main sunscreen agent because of its low ultraviolet absorption efficiency, and can be used as an auxiliary sunscreen agent in application examples.
The three types of chemical sun-screening agents with high safety are all crystal type sun-screening agents, and need to be dissolved for use when in use so as to play a role in uniformly screening the sun. However, the solubility of bis-ethylhexyloxyphenol methoxyphenyl triazine and ethylhexyl triazone, especially, is low, the dissolution is not enough, the precipitation in the product is possible, the use and the efficacy are affected, and the situation is also complained on the market in the past.
There are generally two types of current solutions: 1) While oils with relatively high solubility have been sought, low viscosity oil-soluble liquid sunscreens with relatively high polarity (e.g., ethylhexyl methoxycinnamate, ethylhexyl salicylate, isoamyl p-methoxycinnamate) are generally widely used to solubilize crystalline sunscreens, the highly polar oils in the following table are also commonly used in chemical sunscreen formulations as solvents for crystalline sunscreens.
| Dielectric constant of | |
| Butyl octanol salicylate | 5.4 |
| Adipic acid diisobutyl ester | 5.2 |
| Benzoic acid phenethyl ester | 5.1 |
| Diethylhexyladipate | 4.2 |
| Diethylhexyl sebacate | 4 |
| Benzoic acid C12-15-alcohol esters | 3.8 |
Note: the dioctyl carbonate is medium-polarity grease, and the dielectric constant is 2.4.
However, some studies found, for example, in y.schiemanna, ×, m.wegmanna, p.lerscha, e.heislerb, m.farwicka, in "colloids and surfaces: the physicochemical and engineering fields, journal 2008, p.331, 103-107, published in the text "biological activity of a polar oil-and-fat-enhanced phytosphingosine transdermal penetrant in cosmetic formulations", from which it can be seen that the high polarity of oil and fat may have an effect of promoting penetration to some extent, and penetration as a sunscreen product may increase the safety risk and also reduce the sunscreen efficacy. At the same time, the solubility of the nonpolar oils in crystalline sunscreens is very low. In this sense, the selection of medium polarity grease is a safer choice. Therefore, the invention innovatively selects the dioctyl carbonate as the grease, and the dielectric constant of the dioctyl carbonate is 2.4.
2) The use amount of the grease is increased, which is a common technical means of the formula, so as to ensure that the solvent type sunscreen agent is not separated out in the formula. In common sunscreen formulations, we can often see the use of multiple oils together. However, an increase in the fat content generally not only leads to a greasy use sensation, but also increases the formulation and therefore requires more emulsifiers or stabilizers to stabilize the formulation.
The sun protection for children is a category which particularly emphasizes safety and mildness. Based on the consideration, the principle of ' safety priority, necessary efficacy and extremely simple formula ' is particularly proposed in the research draft of ' technical guide principle of children cosmetics ' issued in 2022 in China, and the requirements that the types of chemical sun-screening agents are not more than 3 and the sun-screening index SPF is not more than 30 ' are particularly proposed for sun-screening products.
Against this background, it is desired to provide a safe, simple, stable, and broad-spectrum sunscreen composition based on the principle of "safety first, efficacy necessary, and formulation simplicity" of children sunscreen.
The invention surprisingly discovers that the solubility of a single sun-screening agent can be increased by compounding bis-ethylhexyloxyphenol methoxyphenyl triazine and ethylhexyl triazone according to a certain proportion, so that mutual solubilization is realized. Meanwhile, the diethylamino hydroxybenzoyl hexyl benzoate in a safe and stable crystal type UVA absorption waveband is added into the sunscreen composition, and the compounded sunscreen composition also has a broad-spectrum sunscreen effect on the basis of meeting the requirements of safety to simplicity and stability.
Disclosure of Invention
In one aspect, there is provided a safe, simple, stable, broad spectrum sunscreen composition comprising:
a primary sunscreen agent which is a combination of bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, and diethylamino hydroxybenzoyl hexyl benzoate, wherein the weight ratio of bis-ethylhexyloxyphenol methoxyphenyl triazine and ethylhexyl triazone is 0.25 to 1.2, wherein the weight ratio of bis-ethylhexyloxyphenol methoxyphenyl triazine to diethylamino hydroxybenzoyl hexyl benzoate is 0.6 to 1.6;
an oil or fat for sunscreen agents, which contains no phenyl group and has a dielectric constant of less than 3;
wherein the weight ratio of the grease to the main sunscreen agent in the sunscreen composition is 1.5-4.
In a preferred embodiment, the oil or fat is selected from: dioctyl carbonate, diethylhexyl carbonate, isopropyl myristate, or combinations thereof.
In a preferred embodiment, the sunscreen composition of the present invention further comprises an auxiliary sunscreen. In a preferred embodiment, the auxiliary sunscreen agent is a macromolecular chemical sunscreen agent or physical sunscreen agent having a molecular weight of more than 500 daltons. In a preferred embodiment, the auxiliary sunscreen agent is selected from: polysiloxane-15, non-nano titanium dioxide or zinc oxide, or a combination thereof.
In a preferred embodiment, the weight ratio of oil to primary sunscreen in the sunscreen composition of the present invention is 1.75.
In a preferred embodiment, the total amount of oil or fat in the sunscreen composition of the present invention is from 1 to 2.
In a preferred embodiment, the critical wavelength of the sunscreen composition of the present invention is equal to or greater than 370 nanometers.
In another aspect, a sunscreen product is provided comprising the sunscreen composition of the present invention and a cosmetically acceptable carrier. In a preferred embodiment, the sunscreen product is selected from: the sunscreen cream for infants, the sunscreen cream for children and adult sensitive people, the sunscreen gel for children and adult sensitive people, the sunscreen spray for children and adult sensitive people and the sunscreen mousse for children and adult sensitive people.
Detailed Description
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are described herein. For the purposes of the present invention, the following terms are defined below.
The term "about" as used herein refers to an amount, level, value, dimension, size, or amount that differs by up to 30%, 20%, or 10% as compared to the amount, level, value, dimension, size, or amount of a reference. The percentages used herein are by weight unless otherwise indicated.
Throughout the specification and claims, unless the context requires otherwise, the word "comprise", and variations such as "comprises" and "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps.
As used herein, "sunscreen composition" refers to a formulation (e.g., lotion, spray, gel, or other topical product) that absorbs and/or reflects some of the Ultraviolet (UV) radiation of the sun and thus helps prevent the negative effects of sun exposure (e.g., sunburn, premature aging, etc.).
The invention selects, compounds and tests the composition from four aspects of safety, simplicity, stability and broad spectrum. Safety is mainly aimed at safety consideration of selection of a sun-screening agent and sun-screening agent grease, the sun-screening agent selects bis-ethylhexyloxyphenol methoxyphenyl triazine (molecular weight is 627 daltons) with UVA and UVB both having certain absorption, ethylhexyl triazone (molecular weight is 822 daltons) with UVB absorption band and diethyl amino hydroxyl benzoyl benzoic acid hexyl ester (molecular weight is 397 daltons) with UVA absorption band, and the grease selects medium polarity grease. To this end, studies have been undertaken primarily with regard to the number limitations of the formulation ingredients and the minimum concentration required to minimize them. So that the mildness can be improved, and meanwhile, the product is more refreshing and not greasy, and the use feeling is improved. Stabilization is the selection of sunscreen from the photostability of the sunscreen, and consideration is made as an assessment of the solubility stability of the sunscreen combination. Broad spectrum, i.e. Critical Wavelength (CW) not less than 370 nm.
Sunscreen agent
The invention takes safety as the first starting point, takes a crystal type macromolecular sun-screening agent with the molecular weight of more than 500 daltons as a main research object according to the principle from formula to simplification, and provides a safe, simple, stable and broad-spectrum sun-screening composition.
The invention discovers that the solubility of a single sun-screening agent can be increased by compounding bis-ethylhexyloxyphenol methoxyphenyl triazine and ethylhexyl triazone according to a certain proportion, and mutual solubilization is realized, so that the minimum usage amount of the grease solvent is reduced. Accordingly, the present invention provides a sunscreen composition comprising bis-ethylhexyloxyphenol methoxyphenyl triazine and ethylhexyl triazone. The sunscreen composition disclosed by the invention selects the combination of bis-ethylhexyloxyphenol methoxyphenyl triazine and ethylhexyl triazone, and the necessary addition amount of grease is reduced as much as possible by optimizing the combination proportion of the sunscreen agent, so that multiple balance of safety, simplicity and stability with use feeling is achieved.
Meanwhile, on the basis of the research of the sunscreen solubilizing composition, the diethylamino hydroxybenzoyl hexyl benzoate in the UVA absorption waveband is added to achieve the broad-spectrum sunscreen function point. The invention mainly aims to solve the problem that the basic broad-spectrum sunscreen function (the critical wavelength of the sunscreen product reaches 370 nanometers) is reached, and the UVB protection index SPF is higher as much as possible.
The sunscreen composition of the present invention can be used alone, satisfying the simple combination of 3 chemical sunscreens with one oil, and can also be combined with other chemical sunscreens (e.g., polysiloxane-15) or physical sunscreens (e.g., non-nano titanium dioxide or zinc oxide) to expand the application range.
In some embodiments, the weight ratio of bis-ethylhexyloxyphenol methoxyphenyl triazine and ethylhexyl triazone in the sunscreen composition is from 0.25 to 1.2. In a preferred embodiment, the weight ratio of bis-ethylhexyloxyphenol methoxyphenyl triazine and ethylhexyl triazone in the sunscreen composition is from 0.25 to 1. In some embodiments, the weight ratio of bis-ethylhexyloxyphenol methoxyphenyl triazine to diethylamino hydroxybenzoyl hexyl benzoate in the sunscreen composition is from 0.6 to 1.6. In a preferred embodiment, the weight ratio of bis-ethylhexyloxyphenol methoxyphenyl triazine to diethylamino hydroxybenzoyl hexyl benzoate in the sunscreen composition is from 0.6 to 1.5. In some embodiments, the weight ratio of ethylhexyl triazone to diethylaminobenzoyl hexyl benzoate in the sunscreen composition is from 1.5 to 2.4.
In some embodiments, the sunscreen composition comprises at least about 3% by weight of one or more sunscreen agents, based on the total weight of the composition. The sunscreen composition may comprise from about 3 to about 35 weight percent of one or more sunscreen agents, based on the total weight of the composition. The sunscreen composition may comprise from about 3 to about 10 wt% of one or more sunscreen agents, based on the total weight of the composition.
Sunscreen oils and fats
To address the solubility problem of chemical sunscreens, oils are often used to solubilize the sunscreen.
According to the invention, the medium-polarity grease which is as mild, non-greasy and non-sticky as possible is selected as a solvent of the sunscreen agent, and the necessary addition amount of the grease is reduced as much as possible by optimizing the combination ratio of the sunscreen agent, so that multiple balance of safety, simplicity and stability in use is achieved.
In some embodiments, a single medium polarity grease with good solubility is selected, a proper grease adding amount is confirmed, and then the optimal selection of the dissolution stability of the ratio of the crystallization type sunscreen agent bis-ethylhexyloxyphenol methoxyphenyl triazine to ethylhexyltriazone is carried out. The method for verifying the dissolution stability adopts a low-temperature tracking test at 4 ℃ in a common stability standard method for cosmetics, and the low-temperature stability requirement is met by keeping the stability for 12 weeks at the low temperature of 4 ℃ without precipitation according to the common stability requirement.
In some embodiments, 1 non-polar to medium polar oil may be added as a dispersant to meet mild safety requirements in view of the dispersion requirements of the physical sunscreen, whereby the amount of oil in the sunscreen formulation is 1-2.
In some embodiments, the sunscreen composition comprises a lipid having a dielectric constant of less than 6 that is free of phenyl groups. In a preferred embodiment, the sunscreen composition comprises an oil having a dielectric constant of less than 3. In a preferred embodiment, the sunscreen composition comprises an oil having a dielectric constant of from 1 to 3. In a more preferred embodiment, the sunscreen composition comprises an oil having a dielectric constant of from 2 to 3.
In some embodiments, the oil or fat in the sunscreen composition is selected from the group consisting of: dioctyl carbonate, diethylhexyl carbonate, isopropyl myristate, ethylhexyl salicylate, glyceryl cocoate, isononyl isononanoate, butyl octanol salicylate, diisobutyl adipate, phenethyl benzoate, diethylhexyl adipate, diethylhexyl sebacate, C12-15 alcohol benzoate, or combinations thereof. In a preferred embodiment, the oil or fat in the sunscreen composition is selected from the group consisting of dioctyl carbonate, diethylhexyl carbonate, isopropyl myristate.
In some embodiments, the weight ratio of oil to sunscreen in the sunscreen composition is from 1.5 to 4. In a preferred embodiment, the weight ratio of oil to sunscreen in the sunscreen composition is from 1.5 to 2. In a preferred embodiment, the weight ratio of oil to sunscreen in the sunscreen composition is 1.75.
Based on the example research of the sunscreen solubilizing composition, the dioctyl carbonate which is found to have good solubility is selected as the grease solvent, and the mass ratio of the dioctyl carbonate (bis-ethylhexyloxyphenol methoxyphenyl triazine + ethylhexyl triazone) is =7:3, adding 1 part by mass of diethylamino hydroxybenzoyl hexyl benzoate to a substrate, and testing the low-temperature dissolution stability of the bis-ethylhexyloxyphenol methoxyphenyl triazine and ethylhexyl triazone in different proportions. Thus, in a preferred embodiment, the oil or fat in the sunscreen composition: bis-ethylhexyloxyphenol methoxyphenyl triazine + ethylhexyl triazone: the weight ratio of diethylamino hydroxybenzoyl hexyl benzoate is 7.
In some embodiments, the sunscreen composition may comprise from about 5% to about 20% by weight of the oil, based on the total weight of the composition. The sunscreen composition may comprise from about 8% to about 15% by weight of the oil based on the total weight of the composition. The sunscreen composition may comprise from about 8% to about 12% by weight of the oil based on the total weight of the composition.
Sunscreen composition
The safety sun protection of the invention mainly focuses on the following two aspects: the choice of sunscreen and the choice of oil.
The selection of the sunscreen agent should meet the list and limited range of cosmetic safety technical specifications. The selection of safe chemical sunscreens included selecting chemical sunscreens with a relatively large molecular weight (above 390 daltons) and a green color according to the american Environmental Working Group EWG (Environmental Working Group) composite score. Also, safer physical sunscreen options include: 1) A reasonable test method is adopted to represent that the aggregation state particle size of the physical sun-screening agent raw material is more than 100 nanometers; and/or 2) if the physical sunscreen titanium dioxide is selected, it is desirably of the rutile type and is surface treated. Chemical sunscreen systems and physical sunscreen systems that meet the above sunscreen requirements can be used alone or in combination.
The oil or fat is preferably selected from non-phenyl, non-polar, low-polar or medium-polar oils or fats. The identity of the polarity of the grease may be characterized by reference to the dielectric constant or the polarity classification of a professional grease manufacturer.
The invention relates to the simple requirements mainly reflected in the necessity and the quantity of raw materials. The raw materials used must have certain functions from the viewpoint of efficacy, stability and safety, and cannot be omitted. The amount of raw materials used is limited. The present invention focuses on sunscreens and greases, and therefore has two considerations: sunscreen number limitation: for children aged 12 and under, the amount of sunscreen does not exceed 3; for adult sunscreens, the number of sunscreens is recommended to be no more than 5; and grease quantity limitation: not more than 3.
The broad spectrum of the invention mainly refers to the American requirement, and the critical wavelength is not lower than 370 nanometers according to the method of ISO 24443. Alternatively, the UVA-PF/SPF value is not less than 0.33, as referred to European Union requirements. In a preferred embodiment, broad spectrum sunscreen is required to meet both requirements.
Higher UVA protection rates are considered in the aspect that the ratio of UVA-PF/SPF is not lower than 0.45.
In some embodiments, the sunscreen compositions of the present invention have a pH of 6 to 8. In a preferred embodiment, the pH of the sunscreen composition of the present invention is from 6.5 to 7.5.
The compositions may be prepared using mixing and blending methods well known in the sunscreen and cosmetic arts.
The composition may be combined with a "cosmetically acceptable topical carrier", i.e., a topical carrier capable of containing other ingredients dispersed or dissolved therein and having acceptable properties that render it safe for topical use.
The cosmetically acceptable topical carrier may optionally contain a wide variety of additional oil-soluble and/or oil-dispersible materials commonly used in compositions for application to the skin at levels established in the art. For example, surfactants, emulsifiers, pearlizing or opacifying agents, thickeners, emollients, conditioning agents, humectants, chelating agents, exfoliants, preservatives, pH adjusters, and additives that enhance the appearance, feel, or fragrance of the composition, such as colorants, fragrances, tactile modifiers, and the like, may be included.
Application method
As used herein, "topically applying" means spraying, wiping, spreading or spreading directly on the outer skin or scalp, for example, by hand or by an applicator such as a wipe, roller or spray.
The sunscreen composition may be applied to the skin of the user in any desired manner. In some aspects, the product may be applied directly by hand, or the product may be applied using a device such as a cosmetic cotton or other implement. The composition is advantageously applied to the skin in order to facilitate sample absorption. The composition may be left on the area to be applied for a desired level of time, such as from about 5 seconds to about 5 minutes. Alternatively, the composition may be left on the area of application and continued to be applied until absorption.
The compositions of the present invention are sprayable. As used herein, "sprayable" means that the composition, when manually actuated or released by pressurization from a dispensing mechanism such as a bottle or aerosol can having a pump spray nozzle, produces an evenly distributed and reproducible spray pattern over an area of defined shape (e.g., circular, annular) and size. The composition may be sprayable without the use of a propellant, i.e., in a non-aerosol form.
The invention will be further illustrated by the following specific examples. It should be noted that the examples are given solely for the purpose of illustration and are not to be construed as limitations on the scope of the invention, as many insubstantial modifications and variations of the invention may be made by those skilled in the art in light of the above teachings. Test methods in which specific conditions are not specified in the following examples are generally carried out under conventional conditions or under conditions recommended by the manufacturer. All percentages and parts are by weight unless otherwise indicated.
Experimental materials:
bis-ethylhexyloxyphenol methoxyphenyl triazine, supplied by BASF (trade name Tinosorb S), hereinafter referred to as TS;
ethylhexyl triazone, supplied by BASF (trade name Uvinul T150), hereinafter referred to as T150;
diethyl hydroxy benzoyl hexyl benzoate, supplied by BASF (trade name Uvinul A Plus), hereinafter referred to as A-Plus;
dioctyl carbonate, supplied by BASF (trade name Cetiol CC), is hereinafter abbreviated CC.
Example (b): sunscreen composition and stability study thereof
Weighing bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate and dioctyl carbonate according to the mass parts shown in Table 1, heating to 85-90 ℃ while stirring until the materials are completely dissolved, pouring the materials into a glass bottle preheated in a 60 ℃ oven, and continuously placing the glass bottle in the 60 ℃ oven for heat preservation. And preparing 2# to 10# samples according to the mass parts in the following table in the same operation, and after 8 samples are prepared, putting all the samples into a 60 ℃ oven together for keeping the temperature of the samples prepared in sequence at the high temperature of 60 ℃ for 60 minutes. And then putting the sample into a constant-temperature oven at 25 ℃, taking out the sample for 24 hours, observing the sample, then putting the sample into a refrigerator at 4 ℃, and observing the stability.
TABLE 1
And (3) observing stability: taking out the sample to room temperature, placing a flat LED lamp on the desktop at the bottom of the sample, placing the sample on the lamp for visual observation, and placing the bottom for placing the LED so as to find micro precipitation. Once a sample is deposited, the sample is removed and no stability considerations are included, indicated by an "X".
TABLE 2
Therefore, the samples 5#, 6#, 7# and 8# all meet the requirement of the cosmetic low-temperature stability for 12 weeks.
The calculation was performed according to a sun protection calculator developed by DSM corporation, and the critical wavelength calculation was performed for samples # 5 to # 8. With regard to sun screen calculator for DSM, reference may be made to a web sitehttps://www.sunscreen-optimizer.com/index.html？ sid＝50152206270121bc549ea03bc9c21df4. The results are as follows:
TABLE 3
It follows that the broad spectrum sunscreen goal cannot be met if the TS/T150 ratio is further reduced.
As can be seen from the above experiments and calculations, 7 parts by mass of dioctyl carbonate: 1 part by mass of diethylamino hydroxybenzoyl hexyl benzoate: 3 parts by mass of the total of the bis-ethylhexyloxyphenol methoxyphenyl triazine and the ethylhexyl triazone, the low-temperature stability is very good within the range that the mass ratio of the bis-ethylhexyloxyphenol methoxyphenyl triazine to the ethylhexyl triazone is 0.25-1, the requirement of the low-temperature stability of cosmetics for 12 weeks is far met, the critical wavelength of the cosmetic can meet the requirement of broad-spectrum sun protection, and the cosmetic has practical application significance.
Application example
Application scenarios: sunscreen cream, sunscreen emulsion, sunscreen gel, sunscreen spray and sunscreen mousse for children or adult sensitive people
Application example 1: preparation of baby sunscreen cream
The process comprises the following steps: heating phase A to 75 ℃, uniformly dispersing under homogenization, adding phase B heated to 75 ℃, homogenizing for 5 minutes after adding, stirring and cooling to 55 ℃, adding phase C, adjusting pH to 5.0-6.0, stirring and cooling to 50 ℃, adding phase D, homogenizing for 3 minutes after adding, stirring, and cooling to 35 ℃ to obtain the final product.
According to the professional season of the State drug administration and the guidance of professional doctors, the sun protection of infants between 6 months and 2 years old is realized by selecting physical sun protection such as clothes and caps and matching with sun protection products with sun protection index SPF of about 10. The addition amount of the whole oil phase is relatively low, and the oil phase is fresh and not greasy. The application example meets the principles that the SPF is 10, the PA + + and 3 types of chemical sunscreens are satisfied, and the formula is simplified, so that the broad-spectrum sunscreen is achieved, and the product is used as an oil-in-water product without titanium dioxide and zinc oxide physical sunscreens, the cleaning difficulty is reduced, and the product is particularly suitable for infants.
Application example 2: preparation of sunscreen cream suitable for children and adult sensitive people
The process comprises the following steps: heating phase A to 75 deg.C, homogenizing, and dispersing; uniformly grinding and dispersing the phase C on a three-roller grinder for later use; heating phase B to 75 deg.C, adding phase C, mixing, and adding the mixture of phase B and phase C into phase A under the condition of starting homogenization. Homogenizing for 10 min after adding, stirring and cooling to 55 ℃, adding the phase C, adjusting the pH to 5.0-6.0, stirring and cooling to 50 ℃, adding the phase D, homogenizing for 3 min after adding, stirring and cooling to 35 ℃ to obtain the final product.
The second application example is a wide-spectrum sunscreen cream with SPF of 25-30 and PA + + + and is matched with the use of a physical sunscreen agent titanium dioxide (the titanium dioxide can be selected from non-nanometer levels in order to meet the sunscreen requirements of children) on the basis of the invention combination, and the sunscreen cream is also a collocation with higher safety factor. Also meets the requirements of the children sunscreen product. Compared with pure physical sun protection, the use of the chemical sun protection agent improves the efficiency of the sun protection agent and improves the spreadability to a certain extent. Is suitable for daily sun protection requirements of children and sensitive adults.
Application example 3: preparation of sunscreen lotion suitable for children and adult sensitive people
The process comprises the following steps: heating phase A to 75 ℃, uniformly dispersing under homogenization, adding phase B heated to 75-80 ℃, homogenizing for 5 minutes after adding, stirring and cooling to 60-65 ℃, adding phase C, adjusting pH to 5.0-6.0, continuously stirring and cooling to 50 ℃, adding phase E, homogenizing for 2 minutes, continuously stirring and cooling to 35 ℃ to obtain the final product.
The third application example is a broad-spectrum sunscreen emulsion with SPF of about 20-25 and PA + +, and the single oil is matched with 3 sunscreens, so that the formula is simple, the oil is mild, and the emulsion is suitable for daily ultraviolet protection requirements of sensitive people of children and adults.
Application example 4: preparation of sunscreen gel suitable for children and adults
The process comprises the following steps: heating phase A to 75 deg.C, homogenizing, dispersing, adding phase B heated to 75-80 deg.C, homogenizing for 5 min, stirring, cooling to 50 deg.C, adding phase C and phase D, homogenizing for 2 min, stirring, and cooling to 35 deg.C.
The fourth application example is a wide-spectrum sunscreen gel with SPF of about 20-25 and PA + +, and the single oil is matched with 3 sunscreens, so that the formula is simple, the oil is mild, the skin feel is fresh and non-greasy, and the gel is suitable for daily ultraviolet protection needs of sensitive people of children and adults.
Application example 5: preparation of sunscreen spray suitable for children and adult sensitive people
The process comprises the following steps: heating phase A to 75 deg.C for dissolving completely, adding phase B heated to 75-80 deg.C under homogenizing, homogenizing for 5 min, stirring, cooling to 50 deg.C, adding phase C and phase D, homogenizing for 2 min, stirring, and cooling to 25 deg.C.
The fifth application example is a sunscreen spray with SPF of about 30, PA + + +, and broad spectrum sunscreen, has certain waterproof capability, and is suitable for human body. 3 types of the sun-screening agent, and the formula is simplified, so that the sun-screening rule requirements of children are met, and the daily protection requirements of sensitive adults are met in the safe and simplified direction.
Application example 6: preparation of sun-proof mousse suitable for children and adult sensitive people
The process comprises the following steps: heating phase A to 75 deg.C for dissolving completely, adding phase B heated to 75-80 deg.C under homogenizing, homogenizing for 5 min, stirring, cooling to 50 deg.C, adding phase C and phase D, homogenizing for 2 min, stirring, and cooling to 25 deg.C to obtain liquid. Filling a proper amount of the liquid formula into an aerosol can, filling a certain proportion of isobutane and n-propane, and covering and sealing to obtain the liquid.
The sixth application example is a sun-protection mousse with SPF of about 30, PA + + +, and broad-spectrum sun protection, has certain waterproof capability, and is suitable for human bodies. 3 kinds of sunscreens, and the formula is simplified, so that the sun-screening rule requirements of children are met, and the daily protection requirements of sensitive people of adults are met in a safe and simplified direction.
Claims (10)
1. A safe, to simple, stable, broad spectrum sunscreen composition comprising:
a primary sunscreen agent which is a combination of bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, and diethylamino hydroxybenzoyl hexyl benzoate, wherein the weight ratio of bis-ethylhexyloxyphenol methoxyphenyl triazine and ethylhexyl triazone is 0.25 to 1.2, wherein the weight ratio of bis-ethylhexyloxyphenol methoxyphenyl triazine to diethylamino hydroxybenzoyl hexyl benzoate is 0.6 to 1.6;
an oil or fat for sunscreen agents, which contains no phenyl group and has a dielectric constant of less than 3;
wherein the weight ratio of the grease to the main sunscreen agent in the sunscreen composition is 1.5 to 4.
2. The sunscreen composition of claim 1, wherein the oil is selected from the group consisting of: dioctyl carbonate, diethylhexyl carbonate, isopropyl myristate, or combinations thereof.
3. The sunscreen composition of claim 1, wherein the composition further comprises an auxiliary sunscreen.
4. A sunscreen composition according to claim 3, wherein said auxiliary sunscreen is a macromolecular chemical sunscreen or physical sunscreen having a molecular weight of greater than 500 daltons.
5. A sunscreen composition according to claim 3, wherein said auxiliary sunscreen is selected from the group consisting of: polysiloxane-15, non-nano titanium dioxide or zinc oxide, or a combination thereof.
6. A sunscreen composition according to claim 1 wherein the weight ratio of oil to primary sunscreen in the composition is 1.75.
7. A sunscreen composition according to claim 1 wherein the total amount of oil and fat in the sunscreen composition is from 1 to 2.
8. The sunscreen composition of claim 1, wherein the critical wavelength of the sunscreen composition is equal to or greater than 370 nanometers.
9. A sunscreen product comprising the sunscreen composition of any one of claims 1-8 and a cosmetically acceptable carrier.
10. A sunscreen product according to claim 9 selected from the group consisting of: the sunscreen cream for infants, the sunscreen cream for children and adult sensitive people, the sunscreen gel for children and adult sensitive people, the sunscreen spray for children and adult sensitive people and the sunscreen mousse for children and adult sensitive people.
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