CN115812101A - 用于鉴定结肠细胞增殖性病症的rna标志物和方法 - Google Patents

用于鉴定结肠细胞增殖性病症的rna标志物和方法 Download PDF

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CN115812101A
CN115812101A CN202180046619.4A CN202180046619A CN115812101A CN 115812101 A CN115812101 A CN 115812101A CN 202180046619 A CN202180046619 A CN 202180046619A CN 115812101 A CN115812101 A CN 115812101A
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mir
hsa
mirna
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cell proliferative
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弗朗西斯·阿姆斯特朗
史瓦妮·马哈詹
亚当·哈维
安妮莎·特瓦里
大卫·温伯格
杰西·伊顿
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Frinum Holdings
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Frinum Holdings
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
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    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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CN202180046619.4A 2020-04-29 2021-04-27 用于鉴定结肠细胞增殖性病症的rna标志物和方法 Pending CN115812101A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063017552P 2020-04-29 2020-04-29
US63/017,552 2020-04-29
US202063024875P 2020-05-14 2020-05-14
US63/024,875 2020-05-14
PCT/US2021/029361 WO2021222220A2 (en) 2020-04-29 2021-04-27 Rna markers and methods for identifying colon cell proliferative disorders

Publications (1)

Publication Number Publication Date
CN115812101A true CN115812101A (zh) 2023-03-17

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CN202180046619.4A Pending CN115812101A (zh) 2020-04-29 2021-04-27 用于鉴定结肠细胞增殖性病症的rna标志物和方法

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US (1) US20230160019A1 (cg-RX-API-DMAC7.html)
EP (1) EP4143309A4 (cg-RX-API-DMAC7.html)
JP (1) JP2023524016A (cg-RX-API-DMAC7.html)
KR (1) KR20230017206A (cg-RX-API-DMAC7.html)
CN (1) CN115812101A (cg-RX-API-DMAC7.html)
AU (1) AU2021263680A1 (cg-RX-API-DMAC7.html)
CA (1) CA3181389A1 (cg-RX-API-DMAC7.html)
WO (1) WO2021222220A2 (cg-RX-API-DMAC7.html)

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WO2019060716A1 (en) 2017-09-25 2019-03-28 Freenome Holdings, Inc. SAMPLE EXTRACTION METHODS AND SYSTEMS
KR20220015367A (ko) 2019-05-31 2022-02-08 프리놈 홀딩스, 인크. 메틸화된 핵산의 고심도 시퀀싱 방법 및 시스템
AU2021245992A1 (en) 2020-03-31 2022-11-10 Freenome Holdings, Inc. Methods and systems for detecting colorectal cancer via nucleic acid methylation analysis
CN116670510A (zh) 2020-10-05 2023-08-29 福瑞诺姆控股公司 用于结肠细胞增殖性病症的早期检测的标志物
CA3202255A1 (en) 2020-12-21 2022-06-30 Hayley WARSINSKE Markers for the early detection of colon cell proliferative disorders
JP2025517309A (ja) 2022-05-17 2025-06-05 ガーダント ヘルス， インコーポレイテッド 創薬可能な標的を特定するための方法およびがんを処置するための方法
WO2024009221A1 (en) * 2022-07-04 2024-01-11 Artificial Intelligence Expert Srl Method and system for multi-cancer management in subject
US11992318B2 (en) * 2022-07-13 2024-05-28 Celestin B. Bitjonck Diagnostic lab-on-a-chip device
CN118048450A (zh) * 2022-11-15 2024-05-17 杭州诺辉健康科技有限公司 使用miRNA亚型的家族占比检测癌症
US12587274B2 (en) 2023-03-28 2026-03-24 Quantum Generative Materials Llc Satellite optimization management system based on natural language input and artificial intelligence
US12368503B2 (en) 2023-12-27 2025-07-22 Quantum Generative Materials Llc Intent-based satellite transmit management based on preexisting historical location and machine learning
US12603701B2 (en) 2023-12-27 2026-04-14 Quantum Generative Materials Llc Distributed satellite constellation management and control system

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US20100010196A1 (en) * 1997-09-26 2010-01-14 Abt Holding Company Compositions and methods for non-targeted activation of endogenous genes
US20040018973A1 (en) * 2002-01-25 2004-01-29 University Of Pittsburgh Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the liver, and uses thereof
NZ593226A (en) * 2006-01-11 2012-10-26 Genomic Health Inc Gene expression markers (efnb2) for colorectal cancer prognosis
EP2336353A1 (en) * 2009-12-17 2011-06-22 febit holding GmbH miRNA fingerprints in the diagnosis of diseases
JP2013526852A (ja) * 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
WO2011128900A2 (en) * 2010-04-15 2011-10-20 Hadasit Medical Research Services And Development Ltd. Early detection and staging of colorectal cancer using a panel of micro rnas
US20120088687A1 (en) * 2010-10-08 2012-04-12 Baylor Research Institute MicroRNAs (miRNA) as Biomarkers for the Identification of Familial and Non-Familial Colorectal Cancer
EP2718463B1 (en) * 2011-06-08 2016-01-20 Comprehensive Biomarker Center GmbH Complex sets of mirnas as non-invasive biomarkers for dilated cardiomyopathy
US20160076098A1 (en) * 2013-04-12 2016-03-17 Drexel University Methods of diagnosing and treating chronic pain
EP3256607B1 (en) * 2015-02-13 2021-01-20 Patel, Abhijit Ajit Methods for highly parallel and accurate detection of nucleic acids
US10577645B2 (en) * 2016-03-18 2020-03-03 Norgen Biotek Corp. Methods and kits for improving global gene expression analysis of human blood, plasma and/or serum derived RNA
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EP3571315B1 (en) * 2017-01-23 2025-01-08 Gatehouse Bio, Inc. Methods for identifying and using small rna predictors
AU2018243360B2 (en) * 2017-03-29 2023-10-26 Cornell University Devices, processes, and systems for determination of nucleic acid sequence, expression, copy number, or methylation changes using combined nuclease, ligase, polymerase, and sequencing reactions
JP7455757B2 (ja) * 2018-04-13 2024-03-26 フリーノーム・ホールディングス・インコーポレイテッド 生体試料の多検体アッセイのための機械学習実装

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CA3181389A1 (en) 2021-11-04
EP4143309A2 (en) 2023-03-08
EP4143309A4 (en) 2025-01-01
JP2023524016A (ja) 2023-06-08
US20230160019A1 (en) 2023-05-25
WO2021222220A3 (en) 2021-12-09
WO2021222220A2 (en) 2021-11-04
KR20230017206A (ko) 2023-02-03
AU2021263680A1 (en) 2022-11-24

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