CN115804379A - Active substance combinations having acaricidal properties - Google Patents
Active substance combinations having acaricidal properties Download PDFInfo
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- CN115804379A CN115804379A CN202111075606.8A CN202111075606A CN115804379A CN 115804379 A CN115804379 A CN 115804379A CN 202111075606 A CN202111075606 A CN 202111075606A CN 115804379 A CN115804379 A CN 115804379A
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- active compound
- acaricidal properties
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- treatment
- prevention
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- 150000005846 sugar alcohols Polymers 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical class NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
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- 239000000080 wetting agent Substances 0.000 description 1
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to active compound compositions having acaricidal properties, comprising a compound of the formula (I) shown below and at least one active compound selected from component (B); the compositions have excellent acaricidal properties. Active ingredient combinations having acaricidal properties, comprising compounds of the formula (I)
Description
Technical Field
The present invention relates to active compound compositions having acaricidal properties, comprising a compound of the formula (I) shown below and at least one active compound selected from the group consisting of component (B); the compositions have excellent acaricidal properties.
Background
Compounds of formula (I) and methods for their preparation are known from WO2013157229A1 and their pesticidal action has been described.
However, the acaricidal efficacy of the known compounds at low doses is not always satisfactory. Therefore, there is an urgent need for new active compound compositions having improved properties.
It has now been found that active compound compositions comprising a compound of the formula (I) and at least one active compound selected from the following components (B):
(1) Bifenazate, a phenylhydrazine derivative, known from WO93/10083
And/or
(2) Clofentezine (Clofentezine), a mite growth inhibitor that affects chitin synthase 1.
One preferred embodiment relates to compositions comprising a compound of formula (I) and a bifenazate.
Another preferred embodiment relates to a composition comprising a compound of formula (I) and clofentezine.
In particular, the active compound combinations have very good acaricidal properties.
Disclosure of Invention
The invention aims to provide an active compound composition with acaricidal property aiming at the defects.
Surprisingly, the acaricidal efficacy of the active compound compositions according to the invention is significantly higher than the sum of the efficacy of the individual active ingredients, there being an unexpected, true synergistic effect, not only a complementary/additive effect.
The active compound composition with acaricidal properties is realized by adopting the following technical scheme:
active compound combinations having acaricidal properties, comprising a compound of the formula (I) and at least one active compound of component (B) selected from: bifenazate (Bifenazate) and/or Clofentezine (Clofentezine). The synergistic effect is particularly pronounced when the active compounds in the active compound composition according to the invention are present in a certain weight ratio. In general, the compositions according to the invention comprise the compounds of the formula (I) and the active compounds of the component (B) selected from bifenazate and/or clofentezine, in the mixing ratios which are preferred, more preferred and particularly preferred hereinafter.
Preferred mixing ratios of the compound of the formula (I) and the active compound of the component (B): 100, 1 to 1, for example 50.
More preferred mixing ratios of the compound of formula (I) and the active compound of component (B): 10.
The active compound composition with acaricidal property comprises a compound shown as a formula (I) and bifenazate, wherein the weight ratio of the compound shown as the formula (I) to the bifenazate is 20:1-1:20.
the active compound composition with acaricidal property comprises a compound shown in a formula (I) and clofentezine, wherein the weight ratio of the compound shown in the formula (I) to the clofentezine is 10:1-1:10.
the present invention further relates to the use of the active compound compositions according to the invention having acaricidal properties for the prevention and/or treatment of pest infestation in plants, plant parts and/or their surroundings.
The active compound combinations with acaricidal properties are used for preventing and/or treating pests of the acaridae family.
The active compound combinations with acaricidal properties are used for preventing and/or treating Tetranychidae pests.
The active compound combinations with acaricidal properties are used for preventing and/or treating gall acaridae pests.
The active compound composition with acaricidal properties is used for preventing and/or treating tarsondae pests.
The active compound composition with the acaricidal property is used for preventing and/or treating tetranychus urticae koch, panonychus citri, panonychus ulmi, tetranychus gossypii and tetranychus mirabilis.
The active compound composition with acaricidal properties is used for preventing and/or treating acaridae pests in citrus, pome fruit, stone fruit, vegetables, cotton, soybean, grape.
The active compound compositions according to the invention exhibit excellent activity in particular against pests of the order arachnidae. And are active against normally sensitive and resistant species as well as against all or individual developmental stages.
It is particularly preferred that the animal pest is from the order Acarina (Acari), more particularly from the families gall mites (Eriophyideae), tarsonemudae (Tarsonemidae) and Tetranyhidae (Tetranyhidae).
Gall mite families (Eriophyidae) such as tomato sting gall mite, citrus sting gall mite, forfei gall mite, peach silver foil gall mite, gemma citrinum, tulip gall mite, pear leaf rust mite, grape leaf rust mite, litchi gall mite, pear gall mite, black currant gall mite, tea gall mite, citrus rust mite;
tarsonemudae (Tarsonemidae) such as Tarsonemus dorsalis;
tetranychidae (Tetranyhidae) such as short-hair mite of orange, short-hair mite of egg, short-hair mite of austenite, short-hair mite of purplish red, tetranychidae of hornbeam, tetranychidae of Welch, tetranychidae of walnut, tetranychidae of Equidambar orientalis, tetranychus citriodorus, tetranychus citrinopileatus, tetranychus ulmi, tetranychus cinnabarinus, tetranychus turkey, tetranychus urticae, tetranychus xylophilus, tetranychus mirabilis, tetranychus coffex, tetranychus urticae, tetranychus avocado, tetranychus urticae.
The invention also relates to a method for controlling mite infestations of plants, plant parts and/or the environment by applying the active compound composition according to the invention to the plants, plant parts and/or the environment.
The invention also relates to the use of the active compound compositions according to the invention for treating plants selected from the group consisting of citrus, pome fruit, stone fruit, tropical fruit, nuts, berries, vegetables, cotton, soya, grapes, tea, coffee, maize, rice and ornamentals, or parts thereof.
Examples of citrus include orange, lemon, grapefruit, lime, and the like.
Examples of pome fruits include apples, loquat, pears, and the like.
Vegetables include leafy vegetables such as kale, spinach, arugula and lettuce; stem vegetables such as cabbage; flower bud vegetables such as broccoli, cauliflower, artichoke, and euphorbia lathyris; stem vegetables such as asparagus, bamboo shoots, potatoes and sweet potatoes; root vegetables such as carrot, parsnip, beet and radish; bulb vegetables such as onions, garlic and green onions of the genus allium; tomatoes, cucumbers, zucchini and pumpkins of the zucchini genus, peppers (solanaceae, eggplants; beans and peas).
Examples of stone fruits include peaches, nectarines, plums, apricots, cherries, and the like.
Examples of tropical fruits include banana, date palm, dragon fruit, durian, avocado, fig, guava, jackfruit, kiwi, lychee, mango, mangosteen, passion fruit, papaya, pineapple, persimmon, pomegranate, rambutan, and carambola.
Examples of nuts include hazelnuts, almonds, brazil nuts, cashews, macadamia nuts, peanuts, pecans, pine nuts, pistachios, and walnuts.
Examples of berries include blackberry, blueberry, cranberry, gooseberry, grape, raspberry, strawberry.
Examples of ornamental plants include roses, chrysanthemums, tulips, and the like.
Plants are understood as meaning all stages of development, such as seeds, seedlings, young (immature) plants up to mature plants.
Plant parts are understood to mean all parts and organs of plants above and below the ground, such as shoots, leaves, flowers and roots, examples given being leaves, needles, stems, flowers, fruit bodies, fruits and seeds, and tubers, roots and rhizomes. Parts of plants also include harvested plants or harvested plant parts, as well as vegetative and generative propagation material, such as seedlings, tubers, rhizomes, cuttings and seeds.
The acaricidal efficacy of the active compound compositions according to the invention with acaricidal properties is significantly higher than the sum of the efficacies of the individual active ingredients, there being an unexpected, true synergistic effect, not only a complementary/additive effect.
Detailed Description
The invention will be further illustrated with reference to specific examples:
preparation
The invention also relates to formulations comprising the active compound compositions according to the invention as pesticides. Conventional formulation forms are, for example, emulsion Concentrates (EC), water-Soluble Liquors (SL), emulsions in water (EW), suspension concentrates (SC, SE, FS, OD), water-dispersible granules (WG), granules (GR) and capsule Concentrates (CS);
these formulations preferably comprise auxiliaries, such as one or more inert fillers and/or surfactants. The adjuvants used impart certain physical, technical and/or biological properties to the formulations of the active compound compositions according to the invention.
Suitable inert fillers are known in the art and are commercially available.
Examples of suitable liquid inert materials are aromatic hydrocarbons, such as xylene, toluene; aliphatic hydrocarbons such as cyclohexane, paraffin, petroleum fractions, mineral oils and vegetable oils; alcohols, such as isopropanol, butanol or ethylene glycol, and ethers and esters thereof; ketones such as methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone; strongly polar solvents, such as dimethyl sulfoxide; carbonates such as propylene carbonate, butylene carbonate, diethyl carbonate, or dibutyl carbonate; and water.
Examples of suitable solid inert materials are kaolin, clay, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, finely divided silica, alumina and natural or synthetic silicates; a resin; waxes and/or solid fertilizers.
Suitable surfactants include emulsifiers and/or foaming agents, dispersing or wetting agents of ionic or non-ionic nature. Such as polyacrylates; a lignosulfonate; a phenol sulfonate or naphthalene sulfonate; polycondensates of ethylene oxide with fatty alcohols or fatty acids or fatty amines, substituted phenols, preferably alkylphenols or arylphenols; a salt of sulfosuccinic acid ester; taurine derivatives (preferably alkyl taurates); a isethionate derivative; phosphoric esters of polyethoxylated alcohols or phenols; fatty acid esters of polyhydric alcohols; and derivatives of sulfate, sulfonate and phosphate containing compounds, such as alkylaryl polyglycol ethers, alkylsulfonates, alkyl sulfates, arylsulfonates.
Optionally, other adjuvants may be present in the formulation. Examples include perfumes, protective colloids, binders, thickeners, thixotropic agents, penetrants, stabilizers, chelating agents, humectants, and spreading agents.
The formulations preferably comprise from 1% to 98% by weight of the active compound composition according to the invention, or particularly preferably from 5% to 80% by weight of the active compound composition according to the invention, more preferably from 10% to 60% by weight of the active compound composition according to the invention. Based on the weight of the formulation.
The formulations may be prepared in a known manner, for example by mixing the active compound compositions of the invention with auxiliaries, for example liquid carriers, solid carriers and/or further auxiliaries (for example surfactants). The formulations are prepared in a suitable apparatus or before or during administration.
Crop protection
The compound of formula (I) and component (B) may be administered in any desired order, in any combination, sequentially or simultaneously. In addition, in case the compound of formula (I) and component (B) are administered simultaneously, they may be administered as a composition comprising the compound of formula (I) and component (B). The compound of formula (I) and component (B) may be obtained as a single formulation mixture, e.g. of the premixed type, of the concentrated type, of the formulated compound (or product); the compounds of the formula (I) and component (B) can also be used by tank-mix (tank-mix), ready-to-use, soup-spray or paste mixing.
The invention also relates to a method for controlling mite infestations of plants, plant parts and/or the environment by applying the active compound composition according to the invention to the plants, plant parts and/or the environment.
The treatment of plants and plant parts with the active compound compositions according to the invention is carried out directly or by acting on their surroundings using customary treatment methods. The conventional treatment methods are, for example, by dipping, spraying, atomizing, irrigating, evaporating, dusting, fogging, scattering, foaming, coating, spreading, injecting, watering, dripping irrigation.
Formula of efficacy of a combination of two compounds
The expected efficacy of a given combination of two compounds is calculated as follows (see Colby, s.r., "marketing Synergistic and antibacterial Responses of pharmacological compositions", weeds 15, pages 20-22, 1967):
if it is used
X is the control effect of the test compound A at a concentration of m ppm or m g/ha, expressed as a percentage of the untreated control,
y is the control effect of the test compound B at a concentration of n ppm or n g/ha, expressed as a percentage of the untreated control,
e is the control effect expressed as a percentage of the untreated control group using a mixture of A and B in m and n ppm or m and n g/ha,
then
E=X+Y-X*Y/100
If the observed control of the composition is higher than that calculated as "E", then there is a synergistic effect of the combination in killing.
Example A miticide test on Tetranychus urticae
Dissolving the raw medicines of the compound shown in the formula (I), clofentezine and bifenazate respectively with a solvent to prepare a single-dose mother solution, and then diluting the mother solution to a required concentration by using an aqueous solution containing 0.1 percent of Tween-80.
The spider mites to be tested are female adult mites which are consistent in size, healthy and active. The leaves to be tested were healthy, intact and of consistent size. Cotton leaves were punched with a punch into a leaf disk with a leaf surface diameter of 2 cm. Placing a wet sponge block in the culture dish, placing filter paper on the wet sponge block, and placing butterfly on the filter paper for later use. And inoculating the two-spotted spider mite into the solution. Each leaf disc was inoculated with 20 female adult mites.
The treatment was carried out using a POTTER spray tower. The amount sprayed was 2ml per treatment. After treatment, the cotton leaves are placed at a temperature of (25 +/-1) o C, relative humidity (70 +/-10)%, light irradiation ratio L: d is 16:8 in a thermostatic chamber. Each treatment was repeated 3 times. After 2 days the death of the adult mites was observed. The non-responders were considered dead by touching the spider mite's feet and mouth with a small brush nib. To contain a solvent and an emulsifierThe clear water of (1) is used as a control.
The tetranychus urticae mite reduction rate and the control effect of each treatment are calculated according to the following formulas:
the reduction rate of live mites (%) = (number of live mites before application-number of live mites after application)/number of live mites before application × 100
Control effect (%) = (reduction rate of live mites in medicament treatment area-reduction rate of live mites in control area)/(100-reduction rate of live mites in control area) × 100
In addition, the theoretical control effect (%) can be calculated by the Colby formula. When the actual controlling effect (%) is higher than the theoretical controlling effect (%), the composition of the present invention has a synergistic effect.
TABLE 1
The good control of the active compound combinations according to the invention is evident from the above table 1 examples. Although the individual actives are less effective, the compositions show efficacy exceeding the sum of simple efficacy. A synergistic effect exists when the effect of the active compound combination is greater than the sum of the control effects of the active compounds administered alone.
Claims (10)
1. Active ingredient combination having acaricidal properties, characterized in that it contains a compound of the formula (I)
And at least one active compound of component (B) selected from:
bifenazate (Bifenazate) and/or Clofentezine (Clofentezine);
the weight ratio of the compound of formula (I) to the active compound of component (B) is from 100.
2. Active compound composition with acaricidal properties according to claim 1, characterized in that it comprises a compound of formula (I) and bifenazate in a weight ratio of 20:1-1:20.
3. active compound composition with acaricidal properties according to claim 1, characterized in that it comprises a compound of formula (I) and clofentezine in a weight ratio of 10:1-1:10.
4. use of active compound compositions having acaricidal properties according to claim 1 for the prevention and/or treatment of pest infestation in plants, plant parts and/or their surroundings.
5. Use according to claim 4, of active compound compositions having acaricidal properties for the prevention and/or treatment of pests of the acaridae family.
6. Use according to claim 4, of the active compound compositions having acaricidal properties for the prevention and/or treatment of tetranychidae pests.
7. Use according to claim 4, of an active compound composition having acaricidal properties for the prevention and/or treatment of gall acaridae pests.
8. Use according to claim 4, of an active compound composition having acaricidal properties for the prevention and/or treatment of tarsondae pests.
9. Use according to claim 4, of an active compound composition having acaricidal properties for the prevention and/or treatment of Tetranychus urticae, panonychus citri, panonychus ulmi, tetranychus gossypii, tetranychus mirabilis.
10. Use according to claim 4, of active compound compositions having acaricidal properties for the prevention and/or treatment of pests of the acaridae family in citrus, pome fruit, stone fruit, vegetables, cotton, soya, grapes.
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