CN115779244A - Accurate medication method of magnetic capsules - Google Patents
Accurate medication method of magnetic capsules Download PDFInfo
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- CN115779244A CN115779244A CN202211551669.0A CN202211551669A CN115779244A CN 115779244 A CN115779244 A CN 115779244A CN 202211551669 A CN202211551669 A CN 202211551669A CN 115779244 A CN115779244 A CN 115779244A
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- Prior art keywords
- magnetic
- target area
- target
- magnetic field
- microcapsule
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- 239000003814 drug Substances 0.000 title claims abstract description 32
- 229940079593 drug Drugs 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title claims abstract description 15
- 239000002775 capsule Substances 0.000 title claims abstract description 13
- 239000003094 microcapsule Substances 0.000 claims abstract description 28
- 230000000694 effects Effects 0.000 claims abstract description 13
- 210000000130 stem cell Anatomy 0.000 claims abstract description 13
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 9
- 230000017531 blood circulation Effects 0.000 claims description 3
- 230000004807 localization Effects 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 1
- 230000036285 pathological change Effects 0.000 abstract description 4
- 231100000915 pathological change Toxicity 0.000 abstract description 4
- 230000009885 systemic effect Effects 0.000 abstract description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229940126672 traditional medicines Drugs 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/70—Manipulators specially adapted for use in surgery
- A61B34/73—Manipulators for magnetic surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Robotics (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pathology (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
The invention discloses a precise medication method of a magnetic capsule, which comprises the following steps: s1, an operator can perform head space coordinate position stereo orientation on a patient through magnetic resonance and a head stereo orientation device thereof, so as to determine a target spot or a target area needing to be treated; and S2, after the target spot or the target area is determined, the magnetic driving component drives the magnetic generating component to generate a gradient magnetic field, the magnetic driving component can accurately control the gradient magnetic field and change in real time, magnetic field focusing is carried out through the magnetic lens and the spatial magnetic fixed-point control component, the magnetic field of the selected target spot or the target area is strongest, the focused magnetic microcapsules are attracted to gather, and finally the magnetic microcapsules injected into the blood vessel are delivered to the target spot or the target area. The invention allows the determination of the target or target area to be treated; can more effectively and more accurately transport the traditional medicine or stem cells to the pathological change part, increase the medicine effect, improve the utilization rate and reduce the systemic reaction.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to an accurate medication method of a magnetic capsule.
Background
Most of diseases are pathological changes of certain organs, so that dysfunction of the whole system or the whole body is caused, most of the medicines for current treatment are intravascular injection medicines or stem cells, the medicines are transported to the whole body by a circulatory system, part of the targeted medicines can be targeted for treatment through biological targets at present, but most of the medicines are still traditional medicines for the whole body at present, more medicine quantity is needed, more side effects are generated, if the traditional medicines or the stem cells can be more effectively and accurately transported to the pathological changes, the problems can be solved to a certain extent, the medicine effect is increased, the utilization rate is improved, the whole body reaction is reduced, and therefore the accurate medicine administration method of the magnetic capsule is provided.
Disclosure of Invention
The invention aims to solve the defect that the traditional medicine or stem cells cannot be more effectively and accurately transported to a diseased region in the prior art, and provides an accurate medication method of a magnetic capsule.
In order to achieve the purpose, the invention adopts the following technical scheme:
a precise medication method of a magnetic capsule comprises the following steps:
s1, an operator can perform head space coordinate position stereo orientation on a patient through magnetic resonance and a head stereo orientation device thereof, so as to determine a target spot or a target area needing to be treated;
s2, after a target spot or a target area is determined, the magnetic driving assembly drives the magnetic generation assembly to generate a gradient magnetic field, the magnetic driving assembly can accurately control the gradient magnetic field and change in real time, magnetic field focusing is carried out through the magnetic lens and the spatial magnetic fixed-point control assembly, the magnetic field of the selected target spot or the target area is strongest, then the focused magnetic microcapsules are attracted to gather, finally the magnetic microcapsules injected into the blood vessel are delivered to the target spot or the target area, and the content is released at fixed points through the accurate magnetic microcapsule releasing device;
and S3, transmitting the stereotactic space coordinate information of the stereotactic device into a space magnetic fixed point control assembly, wearing the stereotactic device for a long time by a patient, forming a continuous magnetic field attraction effect, and achieving long-time accurate content release.
Preferably, the patient in step S1 lies on the treatment couch, and the treatment couch is moved by the treatment couch driving assembly according to the target point or the target region to be treated, so as to achieve a better magnetic field focusing effect.
Preferably, the magnetic microcapsule is magnetic and can be guided magnetically, the diameter of the magnetic microcapsule is nanometer or micrometer, the magnetic microcapsule can enter the body through injecting into blood vessel, and reach all parts of the whole body through blood circulation, and can be guided magnetically to the target point or target area in a fixed point and stay for a long time, and can release the content under a certain magnetic field intensity.
Preferably, the contents are drugs or stem cells.
Preferably, the stereotactic device can be used as a reference object for magnetic resonance positioning, and can be continuously used as a reference object for target positioning when the magnetic microcapsule device is accurately released for treatment.
Preferably, the operator can control the computer through the operation unit, thereby further controlling the whole device.
Compared with the prior art, the invention has the beneficial effects that:
1. in the invention, the head space coordinate position is stereoscopically oriented by magnetic resonance and a head stereotaxic device, so as to determine a target spot or a target area needing to be treated;
2. in the invention, the device for accurately releasing the magnetic microcapsules is used for carrying out fixed-point magnetic focusing, and the focused magnetic attraction reaches a target point or a target area through the magnetic microcapsules injected into a blood vessel to carry out fixed-point release of drugs or stem cells;
3. in the invention, the stereotactic space coordinate information of the stereotactic device is transmitted into the space magnetic fixed-point control assembly and worn for a long time by a patient, thereby forming a continuous magnetic field attraction effect and achieving the long-time accurate release of drugs or stem cells; thereby more effectively and more accurately transporting the traditional medicine or stem cells to the diseased part, increasing the medicine effect, improving the utilization rate and reducing the systemic reaction.
Drawings
Fig. 1 is a flow chart of a precise medication method of a magnetic capsule according to the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Referring to fig. 1, a precise medication method of a magnetic capsule comprises the following steps:
s1, an operator can control a computer through an operation unit so as to further control the whole device, the operator can perform spatial orientation on the spatial coordinate position of the head of a patient through magnetic resonance and a head spatial orientation device thereof so as to determine a target point or a target area needing to be treated, the patient lies on a treatment couch, and the treatment couch can be moved through a treatment couch driving component according to the determined target point or the target area needing to be treated, so that a better magnetic field focusing effect is realized, and the spatial orientation device can be used as a reference object for magnetic resonance positioning and can be continuously used as a reference object for target positioning when the magnetic microcapsule device is accurately released for treatment;
s2, after a target spot or a target area is determined, a magnetic driving assembly drives a magnetic generation assembly to generate a gradient magnetic field, the magnetic driving assembly can accurately control the gradient magnetic field and change in real time, magnetic field focusing is carried out through a magnetic lens and a spatial magnetic fixed-point control assembly, the magnetic field of the selected target spot or the target area is strongest, then focused magnetic microcapsules are attracted by the focused magnetism to be gathered, finally, the magnetic microcapsules injected into a blood vessel are delivered to the target spot or the target area, fixed-point release of contents is carried out through an accurate release magnetic microcapsule device, the magnetic microcapsules are magnetic and can be magnetically guided, the diameter of the magnetic microcapsules is nanometer or micron, the magnetic microcapsules can enter the body through injection into the blood vessel, reach all parts of the whole body through blood circulation, can be magnetically guided to the target spot or the target area by the fixed-point magnetic device and stay for a long time, and can release the contents under a certain magnetic field intensity, and the contents are medicines or stem cells;
and S3, transmitting the stereotactic space coordinate information of the stereotactic device into a space magnetic fixed point control assembly, wearing the stereotactic device for a long time by a patient, forming a continuous magnetic field attraction effect, and achieving long-time accurate content release.
The working principle is as follows: the head space coordinate position is stereoscopically oriented through magnetic resonance and a head stereotaxic device, and a target spot or a target area needing to be treated is determined; then, fixed-point magnetic focusing is carried out through a precise magnetic microcapsule releasing device, and the focused magnetic attraction reaches a target point or a target area through the magnetic microcapsules injected into the blood vessel to carry out fixed-point drug or stem cells release; the stereotactic space coordinate information of the stereotactic device is transmitted into a space magnetic fixed point control assembly and is worn for a long time by a patient, so that a continuous magnetic field attraction effect is formed, and long-time accurate drug or stem cell release is achieved; thereby more effectively and more accurately transporting the traditional medicine or stem cells to the pathological change part, increasing the medicine effect, improving the utilization rate and reducing the general reaction.
In particular, the magnetic microcapsule of the present invention may be a magnetic vesicle.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (6)
1. The precise medication method of the magnetic capsule is characterized by comprising the following steps:
s1, an operator can perform head space coordinate position stereo orientation on a patient through magnetic resonance and a head stereo orientation device thereof, so as to determine a target spot or a target area needing to be treated;
s2, after a target spot or a target area is determined, the magnetic driving assembly drives the magnetic generation assembly to generate a gradient magnetic field, the magnetic driving assembly can accurately control the gradient magnetic field and change in real time, magnetic field focusing is carried out through the magnetic lens and the spatial magnetic fixed-point control assembly, the magnetic field of the selected target spot or the target area is strongest, then the focused magnetic microcapsules are attracted to gather, finally the magnetic microcapsules injected into the blood vessel are delivered to the target spot or the target area, and the content is released at fixed points through the accurate magnetic microcapsule releasing device;
and S3, transmitting the stereotactic space coordinate information of the stereotactic device into a space magnetic fixed point control assembly, wearing the stereotactic device for a long time by a patient, forming a continuous magnetic field attraction effect, and achieving long-time accurate content release.
2. The method for precise medication of a magnetic capsule as claimed in claim 1, wherein the patient in step S1 lies on the treatment couch, and the treatment couch is moved by the treatment couch driving assembly according to the target point or target area to be treated, so as to achieve better magnetic field focusing effect.
3. The method for precisely administering the magnetic capsule as claimed in claim 1, wherein the magnetic microcapsule is magnetic and can be magnetically guided, the diameter of the magnetic microcapsule is nanometer or micrometer, the magnetic microcapsule can enter the body by injecting into blood vessel, and reach all parts of the whole body by blood circulation, and can be magnetically guided to the target point or target area by fixed point and stay for a long time, and can release the content under a certain magnetic field intensity.
4. The method of claim 1, wherein the contents are drugs or stem cells.
5. The method of claim 1, wherein the stereotactic device can be used as a reference for magnetic resonance localization and can continue to be used as a reference for targeting localization when the magnetic microcapsule device is precisely released for treatment.
6. A method for precise administration of a magnetic capsule according to claim 1, wherein the operator can control the computer by means of the operating unit, thereby further controlling the whole device.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211551669.0A CN115779244A (en) | 2022-12-05 | 2022-12-05 | Accurate medication method of magnetic capsules |
| NL2035771A NL2035771B1 (en) | 2022-12-05 | 2023-09-08 | Precise dosing method for magnetic capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211551669.0A CN115779244A (en) | 2022-12-05 | 2022-12-05 | Accurate medication method of magnetic capsules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115779244A true CN115779244A (en) | 2023-03-14 |
Family
ID=85445808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211551669.0A Pending CN115779244A (en) | 2022-12-05 | 2022-12-05 | Accurate medication method of magnetic capsules |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN115779244A (en) |
| NL (1) | NL2035771B1 (en) |
-
2022
- 2022-12-05 CN CN202211551669.0A patent/CN115779244A/en active Pending
-
2023
- 2023-09-08 NL NL2035771A patent/NL2035771B1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| NL2035771B1 (en) | 2024-06-25 |
| NL2035771A (en) | 2023-11-23 |
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