CN115768469A - Inactivated SARS-CoV-2 virus vaccine - Google Patents

Abstract

SARS-CoV-2 vaccines and compositions and methods of producing and administering the vaccines to subjects in need of the vaccines are described herein.

Description

Inactivated SARS-CoV-2 virus vaccine

Technical Field

The present invention relates to a SARS-CoV-2 vaccine and compositions and methods for producing the vaccine and administering the vaccine to a subject to generate an immune response against SARS-CoV-2.

Background

The natural host of SARS-CoV-2 (hereinafter referred to as "virus") is bat, and the virus belongs to the genus Betacononavirus (betaCoV) of the family Coronaviridae. The ssRNA genome of this virus is 29,903bp (Wuhan-Hu-1 genbank reference sequence: NC-045512.2), encoding 9860 amino acids, 25 non-structural proteins and 4 structural proteins: spike (S) protein, envelope (E) protein, membrane (M) protein, nucleocapsid (N) protein. The virus has a variable size of 60 to 140 nanometers in diameter. It is enveloped and sensitive to ultraviolet light, heat and lipid solvents. It has 89% nucleotide identity with bat SARS-like-CoVZXC 21 and 81% nucleotide identity with human SARS-CoV. There is evidence that when an infected person coughs, droplets carrying virus become airborne and the virus becomes transmitted. These bacteria can be inhaled and if they come into contact with the surface on which they land, and then come into contact with the eyes, nose or mouth, infections can result. In addition, other vectors may be present and the virus may be transmitted by blood transfusion, placental transmission and sexual transmission. While symptoms of SARS-CoV-2 virus infection may be mild, usually involving fever and cough, it may also be asymptomatic, or fatal. The main symptoms are usually high temperature, cough and dyspnea. There is currently no specific treatment or vaccine against this virus, and the only method of prevention is social distance. SARS-CoV-2 constitutes a significant threat to public health. The empire academy of sciences covi-19 (SARS-CoV-2-caused disease) response team issued a report at 3 months and 16 days 2020 in which they evaluated all possible methods to prevent or delay viral spread, ultimately leading to a breakdown of the medical system, with hundreds of thousands of deaths in the uk alone. They point out that only social distances in the whole population range are possible to reduce the impact to a controllable level. These measures must be adhered to before the vaccine comes into play. This recommendation would mean at least 18 months of isolation for most of the population. They concluded that mass production of vaccines, in addition to willingness to sacrifice the elderly, was the only option to prevent this epidemic. In view of this dramatic situation, there is an absolute urgent need to develop an effective SARS-CoV-2 vaccine as soon as possible. In addition, various escape mutants (such as British B.1.1.7; south African B.1.351; brazilian P.1 variants and California variants B.1.427 and B.1.429; see also FIG. 2) have emerged, which further worsen the situation and thus this unfortunate development needs to be solved as well.

Disclosure of Invention

Accordingly, the present invention provides an inactivated SARS-CoV-2 vaccine. While research groups around the world have invested considerable effort in developing SARS-CoV-2 vaccines, most approaches have focused on subunit vaccines (e.g., encoding SARS-CoV-2S proteins or fragments thereof), live attenuated vaccines, or recombinant DNA or RNA vaccines encoding viral proteins. However, there is little interest in whole virus inactivated vaccine methods, and a successful SARS-CoV-2 inactivated vaccine has not yet been completely developed. In the case of inactivated vaccine methods, the use of typical inactivators (such as formaldehyde) and adjuvants (such as alum) under standard conditions can present disadvantages that hinder the development of effective vaccine candidates. In addition, such vaccine candidates may result in Antibody Dependent Enhancement (ADE) of SARS-CoV-2 disease and/or Th2 type immunopathology, which may be caused by hypersensitivity reactions to the SARS-CoV-2 component. The present invention aims to solve these problems and thereby produce a safe and effective whole virus inactivated SARS-CoV-2 vaccine that overcomes the disadvantages of the prior art.

Accordingly, in one aspect of the present invention, there is provided a SARS-CoV-2 vaccine comprising β -propiolactone inactivated SARS-CoV-2 particles; wherein the vaccine is capable of producing neutralizing antibodies against native SARS-CoV-2 particles in a human subject. Preferably the native surface conformation of the SARS-CoV-2 particle is preserved in the vaccine.

In another aspect, the invention provides a SARS-CoV-2 vaccine comprising inactivated SARS-CoV-2 particles; wherein the native surface conformation of the SARS-CoV-2 particle is preserved in the vaccine such that the vaccine is capable of generating neutralizing antibodies and/or other immune responses against native SARS-CoV-2 particles in a human subject, capable of partially or fully protecting more than 50%, preferably more than 60%, more than 70%, more than 80% and more than 90% of the vaccinated human subject.

In particular, the present invention aims to provide optimally inactivated SARS-CoV-2 particles which are incapable of replicating and infecting human cells, but retain immunogenic epitopes of viral surface proteins and are therefore suitable for generating protective immunity in vaccinated subjects. By optimizing the inactivation process and other steps in vaccine production, including the selection of appropriate adjuvants, a new vaccine composition can be obtained that retains the native surface conformation of SARS-CoV-2 particles and reduces the risk of adverse reactions such as ADE and immunopathology. Such vaccine compositions are described in more detail below.

In another embodiment, the invention aims to provide an optimal combination of different SARS-CoV-2 particles that are optimally inactivated, which particles are unable to replicate and infect human cells, but retain immunogenic epitopes of the viral surface protein, and are therefore suitable for generating protective immunity in vaccinated subjects. By optimal combination of different and optimally inactivated SARS-CoV-2 particles, an improved vaccine composition can be obtained, which is capable of generating neutralizing antibodies and/or other immune responses against native SARS-CoV-2 particles in human subjects, capable of partially or fully protecting more than 50%, preferably more than 60%, more than 70%, more than 80% and more than 90% of said vaccinated human subjects.

Each of the limitations of the present invention may include various embodiments of the present invention. It is therefore contemplated that each limitation of the invention relating to any one element or combination of elements may be included in the various aspects of the invention. The invention is not limited in its application to the details of construction and the arrangement of components set forth in the following description or illustrated in the drawings. The invention is capable of other embodiments or of being practiced or carried out in various ways.

Drawings

The figures are not drawn to scale. The drawings are merely illustrative and are not required for practicing the disclosure. For purposes of clarity, not every component may be labeled in every drawing. In the drawings:

FIG. 1is the preparation process of inactivated SARS-CoV-2 vaccine of the present invention. The steps include cell aggregation of Vero host cells, infection of Vero cells with SARS-CoV-2, virus harvesting, DNA reduction, primary inactivation, purification, optional secondary inactivation, and formulation with an adjuvant.

FIG. 2 during the SARS-CoV-2 pandemic, SARS-CoV-2 genomic sequences from isolates around the world have been reported, including recent new variants or lineages, such as British B1.1.7, brazil P1, california B.1.427/B.1.429 and south African B.1.351 lineages. The accession number and source of the complete SARS-CoV-2 genomic sequence are provided in tabular form, as well as the accession numbers of the corresponding orf1ab polyprotein and S protein (if available) (-or no accession = not available).

FIG. 3. Preferred set-up of sucrose gradient centrifugation is used as the polishing step for SARS-CoV-2 vaccine of the invention.

FIG. 4 Total IgG response to SARS-CoV-2 vaccine. Coating antigen: s1 (a), spike protein (B) and nuclear protein (C). End-point titers: absorbance 3 times of blank (dashed line) used as cutoff.

FIG. 5 IgG1 and IgG2a titers in response to SARS-CoV-2 vaccine with alum adjuvant. The specific antibody titer of the S1 protein was determined by ELISA. The concentration was determined by comparison to a mAb subclass standard curve.

Figure 6. Preparation procedure delivers high density and intact spike protein. Shown is an electron micrograph of a SARS-CoV-2 inactivated drug prepared according to example 1. About 1-1.5.10 per AU ⁷ And (c) viral particles.

FIG. 7 size exclusion chromatography and SDS-PAGE profile comparison of SARS-CoV-2 and JEV drugs. High purity (> 95%) according to SDS-PAGE (silver staining, reduction), and monomeric virus (> 95%) according to SE-HPLC. The difference in retention time due to different virus particle sizes (JEV (IXIARO) about 50nm, SARS-CoV2 about 100 nm).

Study design of nhp challenge study. Three groups of 8 animals each; two dose groups of SARS-CoV-2 vaccine (10 AU and 40AU, 0.5 mg/dose Al added directly before administration ³⁺ And 1mg Th1 stimulating adjuvant/dose formulation) and placebo group (DPBS). The SARS-CoV-2 challenge strain is BetacoV/France/IDF/0372/2020 (Maison Masse et al, hydroxychloroquinone use against SARS-CoV-2infection in non-human primates,2020, nature 585 584-587). Detection method and timing: hematology of d-28, d0, d7, d14, d21, d28, d35, d47, d49, d50, d51, d54, d62. Ab reaction (ELISA, IFA) of d-28, d0, d14, d21, d28, d35, d47, d54, d62. d-28, d0, d14, d35, d54, d 62T cell response (ICS, ELISPOT). d47, d49, d50, d51, d54, d62 (LUMINEX). Swabs (viral load (qRT PCR genome + subgenomic): nasal and tracheal swabs for d35, d49, d50, d51, d54, d57, d 62; rectal swabs for baseline and d2, d7, d15 BAL viral load (qRT PCR genome + subgenomic): d50. Euthanasia: lung harvest, viral load (qRT-PCR genome + subgenomic): d54, d62.Ct scan: d35, d50, d57.

Fig. 9.33 neutralizing mabs or residue counts within the footprint of clusters 13, 4, 10, 2,1, 3, respectively. Listed are lineages (labeled "x") that neutralize residues within the mAb footprint and/or define the b.1.1.7, b.1.351, or p.1 mutation positions. For example, the K417 and E484 mutations are amino acid positions in the S protein, found only in the south africa and brazilian lineages.

FIG. 10 SDS-PAGE silver staining of two SARS-CoV-2 candidate samples according to example 1 (iCELLIS 500 bioreactor, protamine sulfate precipitation, BPL inactivation). These bands can be unambiguously assigned to three major viral proteins (spike-protein, membrane protein, nucleoprotein) as well as background proteins from the host system.

FIG. 11 SARS-CoV-2 mutations within spike proteins of strain UK MIG457 (B.1.1.7 lineage) and strain SA _ P2 (B.1.351 lineage) from the UK public health agency (PHE).

Detailed Description

Embodiments of the invention relate to SARS-CoV-2 vaccines or immunogenic compositions comprising inactivated SARS-CoV-2 particles. Typically, the inactivated SARS-CoV-2 particle is a whole virus, inactivated particle, i.e., the inactivated virus particle is derived from an inactivated whole native SARS-CoV-2 particle. As used herein, "SARS-CoV-2" refers to SARS-CoV-2 virus, and "SARS-CoV-2 particle" generally refers to the entire SARS-CoV-2 virus particle, i.e., the virion.

In some embodiments of the invention, SARS-CoV-2 particle is inactivated without substantially altering its surface structure. In other words, the native surface conformation of SARS-CoV-2 particle is retained in the inactivated viral particle. It has surprisingly been found that by optimizing the inactivation process, e.g., using beta-propiolactone, the infectivity of native SARS-CoV-2 particles can be substantially eliminated without adversely affecting their antigenicity and/or immunogenicity. Accordingly, the present invention provides, in one aspect, an inactivated viral vaccine (e.g., a beta-propiolactone inactivated viral vaccine) that generates neutralizing antibodies and/or protective immunity against SARS-CoV-2 infection.

In one embodiment, SARS-CoV-2 particles are inactivated by methods that preferentially target viral RNA. This means that, for example, the inactivation step is more capable of modifying viral RNA than viral proteins. Thus, inactivated SARS-CoV-2 particles may comprise viral RNA that is replication-defective, i.e. the viral RNA is modified in the inactivation step such that the inactivated particles cannot replicate. The present invention advantageously allows for the retention of immunogenic epitopes in viral surface proteins by using an inactivation method that preferentially targets viral RNA.

Preferably, the inactivation method spares the viral (surface) proteins relative to the viral RNA as compared to the viral RNA, e.g., the viral surface proteins (e.g., spike (S) proteins) may contain fewer or less frequent modifications resulting from the inactivation step. For example, the proportion of amino acid residues in a viral surface protein (e.g., S protein) is lower compared to the proportion of modified nucleotide residues in the viral RNA. In some embodiments, the proportion of modified amino acid residues in the viral surface protein (e.g., S protein) may be at least 5%, 10%, 20%, 30%, 50%, 70%, or 90% lower than the proportion of modified nucleotide residues in the viral RNA. "modification" or "modified residue" refers to a non-natural residue not present in native SARS-CoV-2 particles, e.g., a chemical (covalent) modification of such a residue resulting from an inactivation step.

In one embodiment, viral RNA is inactivated by alkylation and/or acylation, i.e. the modification in the SARS-CoV-2 inactivated particle comprises alkylated and/or acylated nucleotide residues. In some embodiments, the modification is preferentially directed to purine (particularly guanine) residues, e.g., SARS-CoV-2 inactivated particles comprise one or more modified (e.g., alkylated or acylated) guanine residues. In certain instances, the inactivation step may result in cross-linking of the viral RNA to viral proteins, for example, via guanine residues in the viral RNA. The inactivation step may also introduce gaps or strand breaks into the viral RNA, e.g., resulting in fragmentation of the viral genome.

Suitable alkylating and/or acylating agents are known in the art. In one embodiment, the inactivating agent comprises beta-propiolactone, i.e. the vaccine comprises beta-propiolactone inactivated virus particles. In any event, in particular embodiments, beta-propiolactone (also referred to herein as "BPL") treatment is particularly preferred in accordance with the present invention because it results in SARS-CoV-2 particles that are substantially inactive, but retain high antigenicity and immunogenicity against neutralizing epitopes present in native SARS-CoV-2. In particular, it has been surprisingly found that beta-propiolactone can inactivate SARS-CoV-2 particles with a minimal number of protein modifications. For example, as shown in examples 6 and 7 below, inactivation of SARS-CoV-2 particles using beta-propiolactone results in a much lower number of modifications of viral proteins than inactivation of influenza particles using beta-propiolactone. Thus, in the beta-propiolactone inactivated SARS-CoV-2 particle, the native surface conformation of the viral particle can be retained.

In a preferred embodiment of the invention, the viral RNA is inactivated in an optimized manner, i.e. the viral RNA is only sufficiently inactivated, no longer infectious, but not "over" inactivated, so that a large number of modifications occur at different amino acids, in particular the S protein. In a further more preferred embodiment, BPL inactivation not only sufficiently inactivates (but not excessively inactivates) SARS-CoV-2 virus, but also sufficiently inactivates viruses that can be co-enriched and co-cultured during manufacture (see, e.g., the experimental section). PPV (porcine parvovirus) is a virus that is particularly difficult to inactivate and can be co-cultured and co-enriched-see the experimental section.

The concentration of beta-propiolactone in the inactivation step may be optimized to ensure complete inhibition of viral replication while maintaining the conformation of the viral surface proteins. For example, the concentration of beta-propiolactone in the inactivation step may be, for example, 0.01-1 wt.%, preferably 0.01 to 0.1 wt.%, more preferably about 0.03 wt.%. The preferred amount of BPL was found to be 500ppm, where SARS-CoV-2 virus and other related viruses/impurities were inactivated while retaining (i.e., not modifying) most of the amino acids of the S protein (i.e., showing only a few amino acids to be modified with low probability).

In some embodiments, native SARS-CoV-2 particles may be contacted with beta-propiolactone for at least 5 hours, at least 10 hours, at least 24 hours, or at least 4 days, such as 5 to 24 hours or longer, such as 48 hours. The inactivation step may be carried out at about 0 ℃ to about 25 ℃, preferably about 4 ℃ or about 22 ℃ or e.g. 18 to 24 ℃. In one embodiment, the inactivation step (e.g., using beta-propiolactone) is performed at 2 ℃ to 8 ℃ for 24 hours. The inactivation step may optionally and preferably be followed by a hydrolysis step of the inactivator as is known in the art (e.g., for beta-propiolactone, this may be performed at about 37 ℃ +/-2 ℃ for a total time of 2.5 hours +/-0.5 hours). In general, longer incubation times and/or higher temperatures in the inactivation step may enhance inactivation of the virus, but may also lead to an increased risk of undesired surface modifications of the virus particles, resulting in a reduced immunogenicity. Thus, the inactivation step may be performed, for example, in the shortest time required to produce fully inactivated virus particles. After hydrolysis is complete, in one embodiment, the inactivated virus solution is immediately cooled to 5 ± 3 ℃ and stored there until inactivation is confirmed by high volume plaque assays and serial passage assays.

The inactivation of beta-propiolactone by SARS-CoV-2 particles may preferentially modify cysteine, methionine and/or histidine residues. Thus, in some embodiments, inactivated SARS-CoV-2 particles comprise one or more beta-propiolactone modified cysteine, methionine, and/or histidine residues. However, in embodiments of the invention, the beta-propiolactone inactivated SARS-CoV-2 particles show relatively less protein modification. Thus, for example, inactivated SARS-CoV-2 particles in a vaccine may comprise less than 200, 100, 50, 30, 20, 15, 10, 9, 8, 7, or 6 amino acid residues modified with beta-propiolactone. Preferably, the spike protein of inactivated SARS-CoV-2 particles comprises less than 100, 50, 30, 20, 15, 10, 9, 8, 7, or 6 amino acid residues modified with beta-propiolactone. More preferably, the inactivated SARS-CoV-2 particle or spike protein thereof comprises 20 or fewer, 15 or fewer, 10 or fewer, or 5 or fewer β -propiolactone modified amino acid residues. Most preferably, the inactivated SARS-CoV-2 particle or spike protein thereof comprises 1 to 100, 2 to 70, 3 to 50, 4 to 30, 5 to 25, 5 to 20, 10 to 20, or about 15 beta-propiolactone modified amino acid residues.

In another embodiment, less than 20%, 15%, 10%, 5%, or 4% of the SARS-CoV-2 polypeptide is modified with β -propiolactone. For example, 0.1-10%, 1-8%, 2-7%, or about 3%, 4%, 5%, or 6% of the SARS-CoV-2 polypeptide in the particle can be modified with beta-propiolactone. The beta-propiolactone modification of the residues and/or polypeptides in the vaccine can be detected by mass spectrometry, for example using liquid chromatography-tandem mass spectrometry (LC-MS), for example using the methods described in examples 6 and 7. In this method, SARS-CoV-2 particles can be digested to fragment the protein into SARS-CoV-2 polypeptides for LC-MS-MS analysis. The digestion step may be performed by any suitable enzyme or combination of enzymes, for example by trypsin, chymotrypsin and/or PNGase F (peptide: N-glycosidase F), or by acid hydrolysis, for example. Preferably the percentage of BPL-modified polypeptides detected by LC-MS after enzymatic or acid hydrolysis is: (a) trypsinization, 1 to 5%,2 to 4% or about 3%; (b) Trypsin + PNGase F digestion, 1-5%,2-4% or about 3%; (c) chymotrypsin 1-10%, 3-8%, or about 6%; (d) acid hydrolysis, 1 to 6%, 2 to 5% or about 4%. In this context, a "beta-propiolactone modified" polypeptide means that the polypeptide comprises at least one beta-propiolactone modification, e.g., at least one residue modified by beta-propiolactone.

In some embodiments, the spike protein that inactivates SARS-CoV-2 particles comprises a beta-propiolactone modification at one or more of the following residues: 49. 146, 166, 177, 207, 245, 379, 432, 519, 625, 1029, 1032, 1058, 1083, 1088, 1101, 1159 and/or 1271, for example in SEQ ID NO 3 or in the corresponding position in SEQ ID NO 19, 21, 23, 25 or 27. Preferably, the inactivated SARS-CoV-2 particle comprises a β -propiolactone modification at one or more of the following residues: h49, H146, C166, M177, H207, H245, C432, H519, H625, M1029, H1058, H1083, H1088, H1101, H1159 and/or H1271, for example in SEQ ID NO. 3 or in the corresponding position in SEQ ID NO. 19, 21, 23, 25 or 27. In another embodiment, the inactivated SARS-CoV-2 particle comprises a β -propiolactone modification at one or more of the following residues: h207, H245, C379, M1029 and/or C1032, for example, in SEQ ID NO 3, or in the corresponding position in SEQ ID NO 19, 21, 23, 25 or 27. By "corresponding position" is meant a position in SEQ ID NO 19, 21, 23, 25 or 27 that aligns with position H207, H245, C379, M1029 and/or C1032 in SEQ ID NO 3, e.g., when SEQ ID NO 19, 21, 23, 25 or 27 aligns with SEQ ID NO 3 using the NCBI Basic Local Alignment Search Tool (BLAST).

For example, in some embodiments, the positions in SEQ ID NO 19, 21, 23, 25 or 27 corresponding to H207, H245, C379, M1029 and C1032 in SEQ ID NO 3 are as follows:

Seq ID

3

H207

H245

C379

M1029

C1032

19

H207

H244

C378

M1028

C1031

21

H207

H245

C379

M1029

C1032

23

H204

H242

C376

M1026

C1029

25

H207

H245

C379

M1029

C1032

27

H207

H245

C379

M1029

C1032

in some embodiments, the membrane (M) glycoprotein of an inactivated SARS-CoV-2 particle comprises a beta-propiolactone modification at one or more of the following residues: 125. 154, 155, 159 and/or 210, preferably H154, H155, C159 and/or H210, for example as in SEQ ID NO: 29.

In some embodiments, the nucleocapsid (N) protein of the inactivated SARS-CoV-2 particle comprises a beta-propiolactone modification at M234, for example, in SEQ ID NO: 28.

In some embodiments, less than 30%, 20%, 10%, 5%, 3%, or 1% of the residues in one or more of the following residues in the inactivated SARS-CoV-2 particle are modified with β -propiolactone: (i) In the spike (S) protein, e.g., in SEQ ID NO:3, or in the corresponding position in SEQ ID NO:19, 21, 23, 25 or 27: residues 49, 146, 166, 177, 207, 245, 379, 432, 519, 625, 1029, 1032, 1058, 1083, 1088, 1101, 1159 and/or 1271; preferably H49, H146, C166, M177, H207, H245, C432, H519, H625, M1029, H1058, H1083, H1088, H1101, H1159 and/or H1271; or H207, H245, C379, M1029 and/or C1032; (ii) In membrane (M) glycoproteins, such as those shown in SEQ ID NO: 29: residues 125, 154, 155, 159, and/or 210; preferably H154, H155, C159 and/or H210; and/or (iii) M234 of the nucleocapsid (N) protein, for example as in SEQ ID NO: 28. In preferred embodiments, less than 30%, 20%, 10%, 5%, 3%, or 1% of each residue of at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or more of the inactivated SARS-CoV-2 particles is modified with β -propiolactone. In this paragraph, the percentage of modified residues is intended to refer to the site occupancy, e.g., the ratio of modified to unmodified peptide at the same modification site, normalized to the protein abundance as described in examples 6 and/or 7 below.

In another preferred embodiment, the proportion of β -propiolactone modification residues (i.e., site occupancy) at the following positions in the inactivated SARS-CoV-2 particle is:

(i) In the spike (S) protein (e.g., SEQ ID NO:3 or the corresponding position in SEQ ID NO:19, 21, 23, 25 or 27):

(a) H207: less than 30%, preferably 0.01 to 25%; and/or

(b) H245: less than 10%, preferably 0.1 to 5%; and/or

(c) C379: less than 5%, less than 1% or less than 0.1%; and/or

(d) M1029: less than 5%, less than 1% or less than 0.1%; and/or

(e) C1032: less than 5%, less than 1% or less than 0.1%; and/or

(ii) In membrane (M) glycoproteins (e.g., SEQ ID NO: 29):

(f) H154: less than 5%, less than 1% or less than 0.1%; and/or

(g) H155: less than 10%, preferably 0.1 to 5%; and/or

(h) C159: less than 5%, less than 1% or less than 0.1%; and/or

(i) H210: less than 20%, preferably 0.1 to 10%; and/or

(iii) In the nucleocapsid (N) protein (e.g., SEQ ID NO: 28):

(j) M234: less than 90%, less than 10% or less than 0.1%.

In further preferred embodiments, the proportion of β -propiolactone modification residues (i.e., site occupancy) at each of the following positions in the spike (S) protein (e.g., SEQ ID NO:3 or the corresponding positions in SEQ ID NO:19, 21, 23, 25 or 27) of inactivated SARS-CoV-2 particles is:

(a) Residues H49, H146, C166, H207, H519, M1029, H1083, H1088, H1101, H1159 and/or H1271: less than 20%, preferably from 0.01 to 10%, more preferably from 0.1 to 5%; and/or

(b) Residues M177, C432, H625: less than 30%, preferably from 0.1 to 20%, more preferably from 1 to 10%; and/or

(c) Residues H245, H1058: less than 30%, preferably from 0.1 to 20%, more preferably from 5 to 15%;

in some embodiments, the proportion of beta-propiolactone modified amino acid residues in the inactivated SARS-CoV-2 particle (or spike protein thereof) may be at least 5%, 10%, 20%, 30%, 50%, 70% or 90% lower than the proportion of modified residues in the inactivated beta-propiolactone influenza particle (or Hemagglutinin (HA) or Neuraminidase (NA) protein therein), for example in an influenza particle inactivated under similar conditions as SARS-CoV-2 particles.

In an alternative embodiment, viral RNA can be inactivated by treatment with Ultraviolet (UV) light. UV treatment can be used to preferentially target RNA (as compared to polypeptides) in viral particles, resulting in, for example, modified nucleotides and/or fragments. In some embodiments, UV treatment may be combined with beta-propiolactone treatment to improve inactivation of the virus, for example, the beta-propiolactone treatment step may be followed by the UV treatment step, or vice versa, or the UV treatment step may be performed simultaneously with the beta-propiolactone treatment step.

In other embodiments, native SARS-CoV-2 particles can be inactivated using formaldehyde. However, formaldehyde inactivation is generally less preferred in the present invention because it is less suitable to preferentially target viral RNA and retain immunogenic epitopes in viral surface proteins.

Thus, in a preferred embodiment, the inactivation step (particularly when formaldehyde is used, but also when other inactivating agents such as beta-propiolactone are used) is carried out under mild conditions to maintain the integrity of the surface antigens, particularly the integrity of the S protein.

In one embodiment, this mild inactivation method comprises contacting a liquid composition comprising native SARS-CoV-2 particles with a chemical viral inactivating agent (e.g., any of the chemical inactivating agents described above or a combination thereof, such as formaldehyde or preferably beta-propiolactone) in a container, mixing the chemical viral inactivating agent and the liquid composition comprising SARS-CoV-2 particles under conditions of laminar flow rather than turbulent flow, and incubating the chemical viral inactivating agent and the liquid composition comprising SARS-CoV-2 particles for a sufficient time to inactivate the viral particles. The mild inactivation step is optionally performed in a flexible bioreactor bag. The mild inactivation step preferably comprises 5 or fewer container inversions during inactivation. Preferably, mixing of the chemical virus-inactivating agent and the composition comprising native SARS-CoV-2 particles comprises shaking, rotating, orbital shaking or shaking the container during incubation at a speed of no more than 10rpm for no more than 10 minutes.

Suitable mild or mild inactivation methods are described in the examples below. Further details of such methods are also described in WO 2021/048221, the contents of which are incorporated herein in their entirety.

Typically, the inactivation step substantially eliminates infectivity of the inactivated SARS-CoV-2 particle against mammalian (e.g., human) cells. For example, the infectivity of mammalian cells may be reduced by at least 99%, 99.99%, or 99.9999% compared to native SARS-CoV-2 particles, or inactivated SARS-CoV-2 particles may fail to detect infectivity of human cells. Standard assays can be used to determine residual infectivity and effective viral titer, e.g., plaque assay, TCID50 assay (50% tissue culture infectious dose). For example, the mammalian cell may be an MDCK, COS or Vero cell.

In a preferred embodiment of the invention, the native surface conformation of the SARS-CoV-2 particle is retained within the inactivated viral particle. This means, for example, that one or more or all immunogenic (neutralizing) epitopes are retained in the inactivated viral particle, such that the inactivated particle is capable of producing neutralizing antibodies against native SARS-CoV-2 particles when administered to a human subject. "native surface conformation" refers to the surface conformation found in native SARS-CoV-2 particles, i.e., SARS-CoV-2 particles (virions) that have not been inactivated. The nature of the vaccine or inactivated SARS-CoV-2 particles to produce neutralizing antibodies in a subject can be determined using, for example, a plaque reduction neutralization assay (PRNT assay), e.g., using serum samples from the subject as known in the art.

In a preferred embodiment, the invention comprises that the native conformation of (i) the spike (S) protein, (ii) the nucleocapsid (N) protein, (iii) the membrane (M) glycoprotein and/or (iv) the envelope (E) protein is preserved in the inactivated viral particle. Preferably, the inactivated SARS-CoV-2 particle comprises a native conformation spike (S) protein. Thus, the S (and/or N and/or M and/or E) protein in inactivated SARS-CoV-2 particles preferably comprises one or more (intact) immunogenic (neutralizing) epitopes present in native SARS-CoV-2 particles. Preferably, the S (and/or N and/or M and/or E) protein in the inactivated virus particle is not modified or substantially unmodified by the inactivation step.

Preservation of the surface conformation of the viral particle can be assessed using standard techniques. For example, methods such as X-ray crystallography, mass spectrometry (altering amino acid mass by modification), and cryoelectron microscopy can be used to visualize viral surfaces. The secondary and tertiary structure of proteins present on the surface of viral particles can also be analyzed by methods such as Circular Dichroism (CD) spectroscopy, e.g. in the far (190-250 nm) UV or near (250-300 nm) UV range. Furthermore, retention of native surface conformation can be confirmed by using antibodies against epitopes present on the native viral surface (e.g., in the S protein). Thus, cross-reactivity of anti-SARS-CoV-2 antibodies between inactivated and native virus particles can be used to demonstrate that potential neutralizing epitopes are retained in the vaccine.

The surface conformation of SARS-CoV-2 virus particles, particularly the spike (S) protein, is known and has been published in several recent studies. See, for example, shang, J.et al (Structural basis of receptor homology by SARS-CoV-2.Nature https:// doi.org/10.1038/s41586-020-2179-y (2020)), which describes the crystal structure of the SARS-CoV-2 receptor binding domain. Furthermore, walls et al (Structure, function, and diagnosis of the SARS-CoV-2 spike glucoprotein, cell 180,1-12 (2020),https:// doi.org/10.1016/j.cell.2020.02.058) Cryo EM was used to provide a detailed description of the surface conformation of S proteins and to describe cross-neutralizing antibodies against conserved S protein epitopes. Use from infected persons and convalescent patientsAntibodies to human sera have further elucidated important S protein epitopes (Zhang B et al. Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 tissues.2020 Cell Research 30. Recent studies have also focused on the structure of the SARS-CoV-2 Nuclear cysteine (N) protein, which has been identified as an important antigen in studies using convalescent serum (Zeng W et al. Biochemical characterization of SARS-CoV-2 Nuclear associated protein.2020 BBRC 527 (3): 618-623). Further guidance on potentially important SARS-CoV-2 epitopes is available in the COVIEdb database, a compilation of information from studies of coronavirus epitope mapping: (http://biopharm.zju.edu.cn/coviedb/；Wu J COVIEdb:A Database for Potential Immune Epitopes of Coronaviruses.2020 Front.Pharmacol.11:572249；doi:10.3389/fphar.2020.572249)。

Monoclonal antibodies (including the S protein) against SARS-CoV-2 surface epitopes are described in the literature (as described above), can be obtained from commercial sources and/or can be produced using standard techniques, such as experimental animal immunization. For example, by 9 months and 9 days 2020, at least 169 different SARS-CoV-2 antibodies are available from MyBioSource, san Diego, calif. (e.g., cat. No. MBS8574747, seewww.MyBioSource.com). On the same day, sino Biological US Inc. of Wen, pa. Provided at least 28 different SARS-CoV-2 antibodies (e.g., cat. No.40150-D006, seehttps://www.sinobiological.com/). Further suitable antibodies are described by Ou et al. (propagation of spike glycerol of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV, nature Communications (2020) 11;https://doi.org/10.1038/s41467-020-15562-9). In embodiments of the invention, the skilled person can detect the preservation of the native surface conformation of SARS-CoV-2 (or its S or N protein) by cross-reacting such antibodies with inactivated particles. In other words, the inactivated particles specifically bind to one or more anti-SARS-CoV-2 antibodies, preferably anti-S protein antibodies, directed against a surface epitope, such as antibodies raised against a neutralizing epitope of the native SARS-CoV-2 virion.

The SARS-CoV-2 particles in the vaccine composition can be derived from any known SARS-CoV-2 strain or variant thereof. For example, the virus may be a strain as defined in figure 2, or may comprise a nucleotide or amino acid sequence as defined therein, or a variant sequence having at least 95% sequence identity. For example, in one embodiment, SARS-CoV-2 particle comprises an RNA sequence corresponding to DNA sequence (i) defined in SEQ ID NO:1 (which is also defined in NCBI reference sequence NC-045512.2). "corresponding" will be understood to define a DNA sequence which is the equivalent of a viral RNA sequence, i.e.a DNA or cDNA sequence encoding a viral RNA or a sequence complementary to a viral RNA. As described herein, the inactivation process may result in modification (e.g., alkylation or acylation) and/or fragmentation of the viral RNA, and it is therefore to be understood that the inactivated viral particle may not comprise the entire RNA sequence defined herein, but rather is derived from a native viral particle that does comprise such sequence.

The SARS-CoV-2 particle may also comprise a variant of the known SARS-CoV-2Wuhan-Hu-1 lineage or also referred to as reference lineage, e.g. a sequence having at least 85%, at least 90%, at least 95% or at least 99% sequence identity with SEQ ID NO:1 and/or NCBI reference sequence NC _ 045512.2. Preferably, the variant sequence encodes an infectious SARS-CoV-2 particle, e.g., a native (non-inactivated) SARS-CoV-2 particle, comprising an RNA sequence capable of encapsulating a velogenic SARS-CoV-2 virus.

Further known SARS-CoV-2 particles can also comprise variants of the known SARS-CoV-2 south African lineage B.1.351, e.g., sequences having at least 85%, at least 90%, at least 95%, or at least 99% sequence identity to SEQ ID NO:18 and/or NCBI reference sequence MW 598408. Preferably, the variant sequence encodes an infectious SARS-CoV-2 particle, such as a native (non-inactivated) SARS-CoV-2 particle, comprising an RNA sequence capable of encapsulating a virulent SARS-CoV-2 virus. FIG. 2 gives a further example of a known SARS-CoV-2 south African lineage B.1.351 variant.

Further known SARS-CoV-2 particles can also comprise variants of known SARS-CoV-2 Brazilian lineage P.1, e.g., sequences having at least 85%, at least 90%, at least 95%, or at least 99% sequence identity to SEQ ID NO:20 and/or NCBI reference sequence MW520923. Preferably, the variant sequence encodes an infectious SARS-CoV-2 particle, such as a native (non-inactivated) SARS-CoV-2 particle, comprising an RNA sequence capable of encapsulating a virulent SARS-CoV-2 virus. FIG. 2 gives a further variant example of the known SARS-CoV-2 Brazilian lineage P.1.

Further known SARS-CoV-2 particles may also comprise variants of the known SARS-CoV-2 British lineage B.1.1.7, e.g.sequences having at least 85%, at least 90%, at least 95% or at least 99% sequence identity with SEQ ID NO:22 and/or NCBI reference sequence MW 422256. Preferably, the variant sequence encodes an infectious SARS-CoV-2 particle, such as a native (non-inactivated) SARS-CoV-2 particle, comprising an RNA sequence capable of encapsulating a virulent SARS-CoV-2 virus. FIG. 2 gives a further illustration of the known SARS-CoV-2 British lineage B.1.1.7 variant.

Further known SARS-CoV-2 particles can also comprise variants of the known SARS-CoV-2 California lineages B.1.427 and B.1.429, such as sequences having at least 85%, at least 90%, at least 95% or at least 99% sequence identity to SEQ ID NO:24 and/or SEQ ID NO:26. Preferably, the variant sequence encodes an infectious SARS-CoV-2 particle, such as a native (non-inactivated) SARS-CoV-2 particle, comprising an RNA sequence capable of encapsulating a virulent SARS-CoV-2 virus. Further examples of known variants of the SARS-CoV-2 California lineage can be found in GenBank.

Similarly, in a preferred embodiment, the SARS-CoV-2 particle comprises an S protein of the Wuhan lineage comprising or consisting of (i) the amino acid sequence defined in SEQ ID NO:3, or (ii) an amino acid sequence having at least 95%, at least 97%, or at least 99% identity to SEQ ID NO: 3.

In a further preferred embodiment, the SARS-CoV-2 particle comprises an S protein of south African lineage B1.351 comprising or consisting of (i) an amino acid sequence as defined in SEQ ID NO:19, or (ii) an amino acid sequence having at least 95%, at least 97% or at least 99% identity to SEQ ID NO: 19.

In a further preferred embodiment, the SARS-CoV-2 particle comprises an S protein of the brazilian p.1 lineage comprising or consisting of (i) an amino acid sequence as defined in SEQ ID NO:21, or (ii) an amino acid sequence having at least 95%, at least 97%, or at least 99% identity to SEQ ID NO: 21.

In a further preferred embodiment, the SARS-CoV-2 particle comprises an S protein of the British lineage B.1.1.7 comprising or consisting of (i) an amino acid sequence as defined in SEQ ID NO:23, or (ii) an amino acid sequence having at least 95%, at least 97% or at least 99% identity to SEQ ID NO: 23.

In a further preferred embodiment, the SARS-CoV-2 particle comprises an S protein of the California B.1.427 lineage that comprises or consists of (i) the amino acid sequence defined in SEQ ID NO:25, or (ii) an amino acid sequence having at least 95%, at least 97%, or at least 99% identity to SEQ ID NO: 25.

In a further preferred embodiment, the SARS-CoV-2 particle comprises an S protein of the California B.1.429 lineage that comprises or consists of (i) an amino acid sequence defined in SEQ ID NO:27, or (ii) an amino acid sequence having at least 95%, at least 97%, or at least 99% identity to SEQ ID NO: 27.

In some embodiments, the inactivated SARS-CoV-2 particle binds to other inactivated SARS-CoV-2 particles in the vaccine (other = other sequences).

In some embodiments, the combination of SARS-CoV-2 particles in the vaccine comprises or consists of at least two SARS-CoV-2 particles selected from the group consisting of i) reference Wuhan _1 lineage, e.g., SEQ ID NOs 1, 9, 12, 15; ii) south African B.1.531 lineage, such as SEQ ID NO 18; brazil P.1 lineage, e.g., SEQ ID NO:20; british B.1.1.7 lineage, e.g. SEQ ID NO:22; and California B.1.427 lineage as SEQ ID NO:24 or B.1.429 lineage as SEQ ID NO:26. A preferred embodiment is a combination comprising i) Wuhan — 1 lineage as shown in SEQ ID NO 9; and ii) south Africa B.1.531 lineage, e.g., SEQ ID NO 18.

In another embodiment, the combination of SARS-CoV-2 particles in the vaccine comprises or consists of at least three, such as three SARS-CoV-2 particles selected from the group consisting of: i) Reference Wuhan — 1 lineage, e.g., SEQ ID NOs 1, 9, 12, 15; ii) south African B.1.531 lineage, such as SEQ ID NO 18; brazil P.1 lineage, e.g., SEQ ID NO:20; british B.1.1.7 lineage, e.g. SEQ ID NO:22; and California B.1.427 as shown in SEQ ID NO:24 or B.1.429 lineage as shown in SEQ ID NO:26. A preferred embodiment of such a trivalent vaccine is a combination comprising: i) The Wuhan _1 lineage, e.g., SEQ ID NO 9; and ii) south Africa B.1.531 lineage, e.g., SEQ ID NO 18; and iii) UK B.1.1.7 lineage, e.g. SEQ ID NO:22. Another preferred embodiment of such a trivalent vaccine comprises: i) The Wuhan _1 lineage, e.g., SEQ ID NO 9; and ii) south African B.1.531 lineages, such as SEQ ID NO 18; and iii) Brazilian P.1 lineage, e.g., SEQ ID NO:20.

The similarity between amino acid sequences and/or nucleic acid sequences is expressed in terms of the degree of similarity between the sequences, otherwise referred to as sequence identity. Sequence identity is typically measured in percent identity; the higher the percentage, the more similar the two sequences. Homologs, or variants of a polynucleotide or polypeptide will have relatively high sequence identity when aligned using standard methods.

Methods of sequence alignment for comparison are well known in the art. Various procedures and alignment algorithms are: smith & Waterman, adv.Appl.Math.2:482,1981; needleman & Wunsch, mol.biol.48:443,1970; pearson & Lipman, proc.natl.acad.sci.usa 85, 2444,1988; higgins & Sharp, gene, 73; higgins & Sharp, CABIOS 5, 151-3,1989; corpet et al, nuc.acids Res.16:10881-90,1988; huang et al computer apps.in the Biosciences 8,155-65,1992; and Pearson et al, meth.mol.Bio.24:307-31,1994.Altschul et al, J.mol.biol.215, 403-10,1990, describing in detail the sequence alignment method and calculation of homology.

Once aligned, the number of matches is determined by counting the number of positions at which the same nucleotide or amino acid residue is present in both sequences. Percent sequence identity is determined by dividing the number of matches by the length of the sequence in the identified sequence, or by the hinge length (e.g., 100 contiguous nucleotides or amino acid residues in the sequence in the identified sequence), and multiplying the resulting value by 100. Preferably, the percent sequence identity is determined over the entire sequence length. For example, when aligned with a test sequence of 1554 amino acids, the peptide sequence with 1166 matches was 75.0% identical to the test sequence (1166 ÷ 1554 × 100= 75.0). The percent sequence identification value is rounded to the nearest tenth. For example, 75.11, 75.12, 75.13, and 75.14 are rounded down to 75.1, while 75.15, 75.16, 75.17, 75.18, and 75.19 are rounded up to 75.2. The length value is always an integer.

The NCBI Basic Local Alignment Search Tool (BLAST) (Altschul et al, mol. Biol.215:403, 1990) is available from a variety of sources, including the national center for Biotechnology information (NCBI, bethesda, md.) and the Internet, for the sequence analysis programs BLASTP, BLASTN, BLASTX, TBLASTN and TBLASTX. Instructions on how to use the program to determine the identity of the sequence please access the NCBI website on the internet. The BLAST and BLAST 2.0 algorithms are also described in Altschul et al, nucleic Acids Res.25:3389-3402, 1977. Software for performing BLAST analysis is publicly available through the national center for biotechnology information (ncbi. The BLASTN program (for nucleotide sequences) defaults to use a word length (W) of 11, an alignment (B) of 50, an expectation (E) of 10,m =5,n = -4, and a comparison of the two strands. The BLASTP program (for amino acid sequences) defaults to using a word length (W) of 3 and an expectation (E) of 10, and the BLOSUM62 scoring matrix (see Henikoff & Henikoff, proc. Natl. Acad. Sci. Usa 89, 10915, 1989).

Homologues and variants of a polynucleotide or polypeptide are typically characterized as possessing at least about 75%, e.g., at least about 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity, as counted over at least 50, 100, 150, 250, 500, 1000, 2000, 5000 or 10000 nucleotides or amino acid residues of the reference sequence, over the full length of the reference sequence or over the full length alignment with the reference amino acid sequence of interest. Polynucleotides or proteins having greater similarity to a reference sequence will exhibit increased percent identity, e.g., at least 80%, at least 85%, at least 90%, at least 95%, at least 98%, or at least 99% sequence identity, when assessed by this method. For sequence comparison of amino acid or nucleic acid sequences, typically one sequence is used as a reference sequence to which test sequences are compared. When using a sequence comparison algorithm, test and reference sequences are input into a computer, subsequence coordinates are designated, if necessary, and sequence algorithm program parameters are designated. Default program parameters are used.

An example of a useful algorithm is PILEUP. PILEUP uses a simplification of the progressive alignment method of Feng & Doolittle, mol. Evol.35:351-360, 1987. The method used was similar to that described by Higgins & Sharp, CABIOS 5, 151-153, 1989. Using PILEUP, reference sequences were compared to other test sequences to determine percent sequence identity relationships using the following parameters: default gap weight (3.00), default gap length weight (0.10), and weighted end gap. PILEUP can be obtained from the GCG sequence analysis software package, for example version 7.0 (Devereaux et al, nuc. Acids Res.12:387-395, 1984).

As used herein, reference to "at least 80% identity" refers to at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or even 100% identity to a particular reference sequence, e.g., at least 50, 100, 150, 250, 500, 1000, 5000 or 10000 nucleotides or amino acid residues of the reference sequence or the full length of the sequence. As used herein, reference to "at least 90% identity" refers to "at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or even 100% identity" to a particular reference sequence, e.g., at least 50, 100, 150, 250, 500, 1000, 5000 or 10000 nucleotides or amino acid residues of the reference sequence or the full length of the sequence.

In some embodiments, the inactivated SARS-CoV-2 particles are conjugated to an adjuvant in the vaccine. In some embodiments, the adjuvant is a Th1 response-directing adjuvant. This means that when the vaccine is administered to a subject, the adjuvant promotes the induction of a primary T helper type 1 (i.e. Th 1) immune response (rather than a Th2 type response) in the subject. The Th1 or Th2 targeting properties of commonly used vaccines are known in the art. It has surprisingly been found that the use of adjuvants that promote a predominant Th1 response can increase the immunogenicity of the vaccine, thereby increasing the antiviral response, as well as reducing the risk of adverse effects, such as immunopathology (which may be caused by a predominant Th 2-type response that may result from hypersensitivity to viral components).

In some embodiments, the adjuvant comprises 3-O-deacyl-4' -monophosphoryl lipid A (MPL), saponin QS-21, a CpG-containing oligonucleotide (CpG ODN), squalene, DL- α -tocopherol, a cationic peptide, a deoxynucleotide-containing immunostimulatory oligonucleotide molecule (I-ODN), and/or imiquimod. For example, examples of suitable adjuvants may include: adjuvant system 01 (AS 01), liposomal formulation comprising 3-O-deacyl-4' -monophosphoryl lipid a (MPL) and saponin QS-21; cpG 1018; cpG ODN comprising sequence 5 'TGACTGTGAACGTTCGAGAGATGA 3' (SEQ ID NO: 4); an adjuvant system 03 (AS 03) comprising squalene, DL-alpha-tocopherol and polysorbate 80; IC31 comprising the sequence KLKLKLKLKLKLKLL ₅ Peptides of KLK (SEQ ID NO: 5) and peptides comprising oligo-d (IC) ₁₃ I-ODN (SEQ ID NO: 6); or MF59, an oil-in-water emulsion comprising squalene, tween 80 and Span 85.

In another embodiment, the vaccine or adjuvant does not comprise: cpG-containing oligonucleotides (CpG ODN). In another embodiment, the vaccine or adjuvant does not comprise CpG 1018, i.e., the vaccine or adjuvant does not comprise the sequence 5 'TGACTGTGAACGTTCGAGAGATGA 3' (SEQ ID NO: 4).

In some embodiments, the dose of Th 1-promoting adjuvant (in particular AS01, AS03, MF59, imiquimod or CpG) will be empirically derived. In some embodiments, the dose of Th1 promoting adjuvant will be determined according to previous studies.

In alternative embodiments, the adjuvant may comprise an aluminium salt, such as alumina, aluminium hydroxide or aluminium phosphate. Preferred aluminium salts are aluminium hydroxide with reduced copper content, for example less than 1.25ppb, wo2013/083726 or adjuvants as described in detail in Schlegl et al Vaccine 33 (2015) 5989-5996, based on the weight of the Vaccine composition. In some embodiments, the alum adjuvant is the only adjuvant in the vaccine composition. As used herein, the weight of the alum component refers to the Al in solution ³⁺ Whatever type of aluminum salt is used. For example, 0.5mg of Al ³⁺ Corresponding to 1.5mg alum. In one embodiment, alum (Al) is present in the SARS-CoV-2 vaccine composition ³⁺ ) The amount of (A) is about 0.1 to 2mg/mL, about 0.2 to 1.5mg/mL, about 0.5 to 1.3mg/mL, particularly about 0.8 to 1.2mg/mL, most preferably about 1mg/mL (i.e., 0.5 mg/dose). However, the use of aluminum adjuvants alone in the present invention is generally less preferred because they tend to direct a predominantly Th 2-type immune response. Thus, in embodiments where the vaccine comprises an aluminium salt, it is particularly preferred that the vaccine further comprises a Th 1-directing adjuvant, for example as described above.

Thus in one embodiment, the adjuvant may comprise an aluminium salt and a CpG ODN, such as CpG 1018 (SEQ ID NO: 4). CpG 1018 may be adsorbed on alum and, when used as a combination adjuvant, has been shown to induce Th1 and Th2 responses (Tian et al 2017Oncotarget 8 (28) 45951-45964); i.e., a more "balanced" immune response. In particular, cpG, when administered in combination with alum, has been shown to increase the overall magnitude of the immune response and to reduce the Th2 bias induced by conventional adjuvants such as alum (X.P. Ioannou et al, cpG-stabilizing oligodeoxypeptides, in combination with the present adjuvant, enhance the quality and change of the bias of the immune responses to a hererosvirus glycophorin.200127-137). The dosage range of the combination of CpG and alum may be between 10 μ g and 3 mg.

Typically, the adjuvant is combined with the inactivated SARS-CoV-2 particles during the manufacturing process of the vaccine product, i.e. the manufactured vaccine product contains the adjuvant and is sold/distributed in this form. In an alternative embodiment, the adjuvant may be combined with the inactivated SARS-CoV-2 particles at the point of use, for example, prior to clinical administration of the vaccine (sometimes referred to as "bedside mixing" of vaccine components). Thus, the invention encompasses vaccine products comprising inactivated SARS-CoV-2 particles and adjuvants as described herein, as well as kits comprising the individual components thereof (e.g., suitable for bedside mixing), and the combined use of the individual components of the vaccine in the prevention or treatment of SARS-CoV-2 infection.

The SARS-CoV-2 vaccine can be prepared by a method involving a native SARS-CoV-2 particle inactivation step, as described above. In general, native SARS-CoV-2 particles can be obtained by standard culture methods, e.g.by in vitro preparation of mammalian cells, preferably using Vero cells. For example, native SARS-CoV-2 particles can be prepared using a method similar to that described in WO 2017/109225 and/or WO 2019/057793, the contents of which are incorporated herein in their entirety, wherein methods of preparing zika and chikungunya viruses in Vero cells are described. The procedures described in these documents for passage, harvesting, precipitation, dialysis, filtration and purification are equally applicable to the SARS-CoV-2 particle preparation process of the present invention.

For example, in some embodiments, the method can include purifying inactivated SARS-CoV-2 particles by one or more size exclusion methods, such as (i) sucrose density gradient centrifugation, (ii) a solid phase matrix packed in a column comprising a ligand-activated core and an inactive shell comprising a pore, wherein the molecular weight cut-off of the pore prevents viral particles from entering the ligand-activated core, and wherein molecules smaller than the pore molecular weight cut-off can enter the ligand-activated core and collect the viral particles, and/or (iii) batch or size exclusion chromatography; to obtain purified inactivated SARS-CoV-2 particles. Preferably, in the resulting purified preparation of viral particles, (i) the concentration of residual host cell DNA is less than 100ng/mL; (ii) a residual host cell protein concentration of less than 1 μ g/mL; and (iii) the concentration of residual aggregates of infectious viral particles is less than 1 μ g/mL.

In some embodiments, the method may include the step of precipitating the harvest medium comprising SARS-CoV-2 particles, thereby producing native SARS-CoV-2 particles in the supernatant. The precipitation step may comprise contacting the culture medium with protamine sulfate or benzoate enzyme. By using such a procedure, contaminating DNA from the host cell as well as immature and non-infectious virus particles can be isolated from the preparation. Furthermore, protamine sulfate can be very efficiently separated from the viral fraction, for example using sucrose density centrifugation or solid phase matrix packed in a column comprising a ligand-activated core and an inactive shell comprising pores, wherein the pores comprise a molecular weight cut-off that prevents viral particles from entering the ligand-activated core, and wherein molecules smaller than the molecular weight cut-off of the pores (e.g., protamine sulfate) can enter the ligand-activated core, thereby allowing the production of safer vaccines in high yield.

Thus, the residual host cell DNA of the resulting viral preparation or vaccine may be less than 1. Mu.g/mL, in particular less than 900, 800, 700, 600, 500, 400, 300 or 200ng/mL, preferably less than 150 or 100ng/mL. In a preferred embodiment, the residual host cell DNA of the viral preparation or vaccine is less than 40pg/mL. In some embodiments, the residual host cell protein of the viral preparation or vaccine is less than 10 μ g/mL, in particular less than 9, 8, 7, 6, 5, 4, 3 or 2 μ g/mL, preferably less than 1 μ g/mL. In a preferred embodiment, the residual host cell protein of the viral preparation or vaccine is less than 150ng/mL. In some embodiments, the residual non-infectious viral particles of the viral preparation or vaccine are less than 10 μ g/mL, in particular less than 9, 8, 7, 6, 5, 4, 3 or 2 μ g/mL, preferably less than 1 μ g/mL. In a preferred embodiment, the virus preparation or vaccine has a residual non-infectious virus particle content of less than 100ng/mL.

In some embodiments, the vaccine and/or SARS-CoV-2 particles may comprise residual protamine (e.g., protamine sulfate), typically in minute amounts. In some embodiments, the residual protamine (e.g., protamine sulfate) in the viral formulation or vaccine is less than 2 μ g/mL or 1 μ g/mL, particularly less than 900, 800, 700, 600, 500, 400, 300, or 200ng/mL, preferably less than 100ng/mL; more preferably below the limit of detection by HPLC, especially below the limit of detection of the final drug. In some embodiments, the PS content is tested by HPLC or Size Exclusion Chromatography (SEC). For example, in JEV sucrose gradient cell samples, high performance liquid chromatography was validated as a PS assay as a conventional release assay and is very sensitive (i.e., limit of quantitation (LOQ) is 3 μ g/mL; limit of detection (LOD) is 1 μ g/mL)<And (7) LOD. In one embodiment, HPLC evaluation of PS content can be performed on a Superdex peptide 10/300GL column (GE: 17-5176-01) using 30% acetonitrile, 0.1% trifluoroacetic acid as solvent at a flow rate of 0.6ml/min, a temperature of 25 ℃ and a detection wavelength of 214nm. A more sensitive method for measuring protamine residues in purified virus preparations is Mass Spectrometry (MS). In some embodiments, the residual PS levels in the zika virus preparation are determined by MS or other such high sensitivity methods (e.g., nuclearMagnetic Resonance (NMR)) were tested. In this way, traces of residual PS and fragments and/or decomposition products of PS can be detected, e.g., as low as 10 per typical sample loading ⁶ 、10 ⁷ Or 10 ⁸ And (4) a molecule. In some embodiments, PS levels are tested in pharmaceutical products. In some embodiments, PS levels are tested in a drug.

Preferably, the amount of the inactivating agent (e.g. beta-propiolactone) in the pharmaceutical product or drug substance (e.g. vaccine composition) is very low, e.g. less than 100ppm, less than 10ppm or less than 1ppm (by weight).

The SARS-CoV-2 vaccine can be administered to a subject, preferably a mammalian subject, more preferably a human subject. Typically, a subject at risk of SARS-CoV-2infection is vaccinated against a SARS-CoV-2 vaccine, e.g., to prevent SARS-CoV-2infection and/or to prevent SARS-CoV-2 associated disease (COVID-19). The subject is preferably (i) an elderly subject (e.g., over 65, 70, or over 80 years old); (ii) a pregnant subject; (iii) immunocompromised subjects; or (iv) a child (e.g., a human 18 years old, 16 years old, 14 years old, 12 years old, 10 years old, 8 years old, 6 years old, 4 years old, 2 years old, or younger). The SARS-CoV-2 vaccine described herein is advantageously capable of generating a strong immune response in a subject that is particularly susceptible or susceptible to infection or death by SARS-CoV-2 (i.e., a immunocompromised, pregnant or elderly subject). The SARS-CoV-2 vaccine can be administered to the subject in a single dose or in two or more doses, e.g., at intervals of about 7, 14, 21, or 28 days.

In a preferred embodiment, administration of the vaccine to a human subject does not induce Antibody Dependent Enhancement (ADE) of SARS-CoV-2 associated disease (COVID-19). ADE is a phenomenon in which virus-specific antibodies (e.g., antibodies produced by vaccination) enhance virus entry into host cells and/or virus replication. One advantage of the present invention is that the inactivated SARS-CoV-2 vaccine described herein shows low or no ADE in human subjects and can therefore be safely used for large scale vaccination purposes. In particular, the vaccines described herein retain immunogenic epitopes of high quality, thus generating high neutralizing antibody titers and reducing the risk of subjects taking ADE. As described in the examples, the risk of ADE development can be assessed in non-human primates (see also Luo F et al (2018), virology Sinica 33.

In a further preferred embodiment, administration of the vaccine to a human subject does not result in an immunopathology. It is well known that in certain circumstances vaccines (e.g. SARS-CoV vaccines) may lead to e.g. Th2 type immunopathology, e.g. hypersensitivity reactions of animals to SARS-CoV components. In embodiments of the invention, a Th 1-type response is favored, for example, by using a Th 1-targeting adjuvant (e.g., AS01 or another adjuvant described herein). In particular, a balanced Th2/Th1 type immune response is preferred, such as that induced by the use of a Th2 stimulating adjuvant (e.g. alum) in combination with a Th1 stimulating adjuvant. The risk of immunopathological development can be assessed in animal models, for example, as described in Tseng c.t. et al (2012) PLoS ONE 7 (4): e 35421. In a preferred embodiment of the invention, the vaccine of the invention shows a shift of the Th2/Th1 type immune response to a Th1 type immune response compared to a vaccine adjuvanted with alum.

Any of the SARS-CoV-2 vaccines or compositions described herein can be administered to a subject in a therapeutically effective amount or in a therapeutically effective amount of a dose. As used herein, a "therapeutically effective amount" of a vaccine is any amount that produces a desired response or result in a subject, as described herein, including but not limited to preventing infection, an immune response or enhancing an immune response to SARS-CoV-2, or preventing or reducing symptoms associated with SARS-CoV-2 disease. More specifically, the therapeutic amount of the SARS-CoV-2 vaccine of the invention can be about 0.05 to 50 μ g, more preferably about 0.5 to 10 μ g, total viral protein mass.

In some embodiments, a therapeutically effective amount of a SARS-CoV-2 vaccine or composition described herein is an amount sufficient to produce antigen-specific antibodies (e.g., anti-SARS-CoV-2 antibodies). In some embodiments, the therapeutically effective amount is sufficient to seroconvert the subject with a probability of at least 70%. In some embodiments, the therapeutically effective amount is sufficient to seroconvert the subject with a probability of at least 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or at least 99%. Whether a subject has seroconverted can be assessed by any method known in the art, such as an assay in which a serum sample is obtained from the subject and tested to detect anti-SARS-CoV-2 antibodies. In some embodiments, a subject is seroconverted if a serum sample from the subject contains an amount of anti-SARS-CoV-2 antibody that exceeds a threshold or predetermined baseline. A subject is generally considered seroconverted if the presence of anti-SARS-CoV-2 antibodies (i.e., anti-SARS-CoV-2S protein IgG antibodies) in the subject' S serum sample is increased by at least 4-fold as compared to a serum sample previously taken from the same subject.

In one embodiment, the dose of inactivated SARS-CoV-2 virus in the vaccine composition of the invention is between about 0.01 and 25mAU (milliabsorbance units as assessed by SEC-HPLC x minutes), preferably between about 0.05 and 10mAU, more preferably between about 1 and 5 mAU. In one embodiment, the dose is about 0.05 to 50 μ g total protein, about 0.1 to 25 μ g, about 0.25 to 12.5 μ g, preferably about 0.5 to 5 μ g total protein as measured by the (μ) BCA assay. More preferably, the dose of inactivated SARS-CoV-2 virus in the vaccine composition is at least 2.5 μ g total protein, at least 3.5 μ g total protein, or at least 2.5 μ g total protein, e.g., the vaccine composition comprises 2.5 μ g to 25 μ g,3.5 μ g to 10 μ g, or 4 μ g to 6 μ g total protein per dose, preferably about 5 μ g total protein per dose. In some embodiments, the dose is determined by the total amount of S protein in the inactivated SARS-CoV-2 preparation, as assessed by, for example, ELISA. The quality of the antigen can also be estimated by evaluating the SE-HPLC peak area per dose equivalent (recorded as milliabsorption units x minutes; mAU), estimating the total surface protein to be about 2. Mu.g/ml and the S protein to be about 1. Mu.g/ml. In one embodiment, the dose is about 0.025 to 25 μ g S protein (measured by ELISA), about 0.05 to 12.5 μ g, about 0.125 to 6.25 μ g, preferably about 0.25 to 2.5 μ g S protein.

In a preferred embodiment, the amount of antigen in the SARS-CoV-2 vaccine is determined by ELISA. In one embodiment, the ELISA measures SARS-CoV-2 protein or a portion of the protein, such as nucleocapsid (N), membrane (M), or spike (S) protein; namely, ELISA uses an envelope antibody specific to SARS-CoV-2 protein or a partial protein. In a preferred embodiment, the envelope antibody is specific for the SARS-CoV-2 spike protein S1 subunit, e.g., residues 14-685 (or 14-683) of the S protein sequence of SEQ ID NO:3, 19, 21, 23, 25 or 27, or specific for the Receptor Binding Domain (RBD), e.g., residues 331 to 528 (or 319 to 541) of the S protein sequence of SEQ ID NO:3, 19, 21, 23, 25 or 27 (see FIG. 9). In one embodiment, the ELISA reading is the mass per unit measurement of protein detected, e.g., μ g/mL S protein. In a preferred embodiment, the standard used is a spike protein trimer and the results of the SARS-CoV-2ELISA are reported as "antigen units" (AU), corresponding to the ACE-2 binding capacity of the standard protein (as determined by the manufacturer).

In one embodiment, the amount of SARS-CoV-2 antigen administered to the subject is between about 1 and 100 AU/dose, preferably between about 2 and 75 AU/dose, preferably between about 3 and 60 AU/dose, more preferably between about 3 and 55 AU/dose, more preferably between about 3 and 53 AU/dose. In more preferred embodiments, the amount of SARS-CoV-2 antigen administered to the subject is 3AU, 10AU or 40AU per dose, most preferably 40AU per dose. In further preferred embodiments, the amount of SARS-CoV-2 antigen administered to the subject is at least 10 AU/dose, at least 20 AU/dose, at least 25 AU/dose or at least 30 AU/dose, for example from about 10 to 60 AU/dose, 20 to 50 AU/dose, 25 to 45 AU/dose or 30 to 40 AU/dose, for example about 35 AU/dose. For example, the amount of SARS-CoV-2 antigen (e.g., in AU/dose) can be assessed by the SARS-CoV-2ELISA assay described in example 1. Estimated to be about 1 to 1.5x 10 per AU ⁷ The virus particle, and the amount of SARS-CoV-2 antibody can be interpreted accordingly. Thus, in some embodiments, the amount of SARS-CoV-2 antigen administered to a subject is about 1.5X 10 ⁷ To 1.5X 10 ⁹ Between viral particles/dose, or at about 4.5x10 ⁸ To 9.0x 10 ⁸ Between virus particles/dose, e.g. at least 1.5x 10 ⁸ Viral particles/dose or at least 3.0x 10 ⁸ Viral particle/dose, about 1.5x 10 ⁸ To 7.5x 10 ⁸ Viral particles/dose, or about 4.5x10 ⁸ To 6.0x 10 ⁸ Viral particles/dose.

In some embodiments, the seroconversion rate of a subject is assessed by performing a Plaque Reduction Neutralization Test (PRNT). Briefly, PRNT is used to determine the serum titer required to reduce the number of SARS-CoV-2 plaques by 50% (PRNT 50) compared to control serum/antibody. PRNT50 can be performed using a Vero cell monolayer or any other cell type/line that can be infected with SARS-CoV-2. The subject sera were diluted and incubated with non-inactivated SARS-CoV-2. The serum/virus mixture can be applied to Vero cells and incubated for a period of time. Plaques formed on the Vero cell monolayer were counted and compared to the number of plaques formed by SARS-CoV-2in the absence of serum or control antibody. PRNT ₅₀ The neutralizing antibody threshold for the 1.

In some embodiments, SARS-CoV-2 particles can be formulated for administration in a composition (e.g., a pharmaceutical composition). The term "pharmaceutical composition" as used herein refers to a product made by mixing or combining at least one active ingredient (e.g., inactivated SARS-CoV-2) and one or more inactive ingredients (which may include one or more pharmaceutically acceptable excipients). A preferred pharmaceutically acceptable excipient is Human Serum Albumin (HSA), e.g., in particular recombinant HSA (rHSA). In one embodiment, the SARS-CoV-2 vaccine of the invention contains about 10 to 50 μ g HSA per dose, preferably about 20 to 40 μ g HSA per dose, more preferably about 25 to 35 μ g HSA per dose.

The pharmaceutical compositions, including Vaccines, of The present invention may be prepared according to methods well known and routinely practiced in The art (see, e.g., remington: the Science and Practice of Pharmacy, mack Publishing Co.20th ed.2000; and Ingredients of Vaccines-face from The center for Disease Control and preservation, as described above, as adjuvants and enhancers to help The vaccine improve its performance, preservatives and stabilizers to help The vaccine remain unchanged (e.g., albumin such as Human Serum Albumin (HSA)) or recombinant human serum albumin (rHSA), phenols, glycine). As used herein, the term "vaccine" refers to an immunogenic composition, e.g., a composition capable of inducing an immune response against an antigen (e.g., against a SARS-CoV-2 antigen) in a (human) subject. For example, the vaccine or composition may be capable of producing neutralizing antibodies against SARS-CoV-2. In some embodiments, the vaccine or cocktail is capable of producing antibodies (e.g., igG) against the SARS-CoV-2S (spike) protein. In some embodiments, the vaccine or composition is capable of generating a T cell response against a SARS-CoV-2 protein or peptide, such as a T lymphocyte response against a SARS-CoV-2S protein, a membrane (M) protein, and/or a nucleocapsid (N) protein or peptide derived therefrom. In general, the vaccine or immunogenic composition is capable of inducing a protective effect against a disease caused by an antigen, such as a protective effect against SARS-CoV-2infection (e.g., symptomatic and/or asymptomatic infection) and/or COVID-19 disease.

The pharmaceutical composition is preferably manufactured under GMP conditions. Typically, a therapeutically effective dose of an inactivated SARS-CoV-2 vaccine formulation is used in the pharmaceutical composition of the invention. The inactivated SARS-CoV-2 particles are formulated into a pharmaceutically acceptable dosage form by conventional methods known to those skilled in the art. The dosage regimen is adjusted to provide the best desired response (e.g., a prophylactic response).

The dosage of the active ingredient in the pharmaceutical composition of the invention may be varied so as to obtain an effective amount of the active ingredient to achieve the desired drug response for a particular subject, composition and mode of administration without being toxic to the subject. The selected dosage level depends upon a variety of pharmacokinetic factors including the activity of the particular composition of the invention employed, the route of administration, the time of administration, the rate of excretion of the particular compound employed, the duration of the treatment, other drugs, medicaments and medicaments, compounds and/or materials used in conjunction with the particular composition employed, the age, sex, body weight, condition, general health, and past medical history of the subject being treated.

A physician, veterinarian, or other trained practitioner can begin administration of the inactivated SARS-CoV-2 vaccine used in the pharmaceutical composition at a level below that required to achieve the desired therapeutic effect and gradually increase the dosage until the desired effect is achieved (e.g., production of anti-SARS-CoV-2 virus antibodies). In general, the effective dosage of the compositions of the invention for prophylactic treatment of the human population described herein will depend on a number of different factors, including the mode of administration, the target, the physiological state of the patient, whether the patient is a human or an animal, the other drug being administered, the time of administration, the mode and time of administration, and the desired titer of anti-SARS-CoV-2 antibody. Titration of the dose is required to optimize safety and efficacy. In some embodiments, the administration regimen entails administering a dose of the inactivated SARS-CoV-2 vaccine twice, once on day 0 and once about day 7, subcutaneously or intramuscularly. In some embodiments, the administration regimen entails administering twice as many doses of the inactivated SARS-CoV-2 vaccine subcutaneously, once on day 0 and once about day 14. In some embodiments, the administration regimen entails administering a dose of inactivated SARS-CoV-2 vaccine twice subcutaneously, once on day 0, and once approximately on day 28. In some embodiments, the subject is administered the inactivated SARS-CoV-2 vaccine once. In a preferred embodiment, the SARS-CoV-2 vaccine is administered to the subject more than once, preferably twice. In a preferred embodiment, the vaccine is administered on days 0 and 21. In another preferred embodiment, the vaccine is administered on days 0 and 28.

In further embodiments, the first (basal) dose of the inactivated SARS-CoV-2 vaccine is administered at least 28 days, at least 60 days, at least 70 days, at least 80 days, or 90 days after the first dose, and the second (booster) dose of the inactivated SARS-CoV-2 vaccine is administered. Thus, in some embodiments, the second dose of inactivated SARS-CoV-2 vaccine is administered 30 to 120 days or 1 to 4 months (preferably about 3 months) after the first dose.

In other embodiments, the inactivated SARS-CoV-2 vaccine is administered only as a booster dose, e.g., a first (initial) dose of (different) SARS-CoV-2 is administered, followed by a second (booster) dose of inactivated SARS-CoV-2, e.g., at least 7, 14, 21, 28, 60, or 90 days after the first dose. The first (initial) dose of the SARS-CoV-2 vaccine can include any other vaccine or immunogenic composition that stimulates the immune response and/or protective effect of the subject against the SARS-CoV-2 virus. For example, the first dose of SARS-CoV-2 vaccine can comprise a recombinant viral vector or an mRNA sequence encoding one or more SARS-CoV-2 proteins and/or fragments thereof, e.g., SARS-CoV-2 spike (S) protein. Alternatively, the first dose of SARS-CoV-2 vaccine can comprise a subunit vaccine, e.g., comprising one or more SARS-CoV-2 proteins and/or fragments thereof, e.g., SARS-CoV-2 spike (S) protein or fragments thereof.

Also included within the scope of the invention are kits for prophylactic administration to a subject, e.g., for preventing or reducing the severity of SARS-CoV-2 infection. Such kits may include one or more containers comprising a composition comprising inactivated SARS-CoV-2. In some embodiments, the kit can further include one or more additional components comprising a second composition, e.g., a second vaccine, e.g., a second SARS-CoV-2 vaccine that applies a different technique than the first dose. In some embodiments, the second vaccine is an arbovirus vaccine. In some embodiments, the second vaccine is a japanese encephalitis virus vaccine, a zika virus vaccine, a dengue virus vaccine, and/or a chikungunya virus vaccine.

In some embodiments, the kit can include instructions for use according to any of the methods described herein. The included instructions can include a description of administering a composition comprising an inactivated SARS-CoV-2 vaccine to prevent, delay the onset of, or reduce the severity of SARS-CoV-2 infection. The kit can also include a description of selecting a subject suitable for administration based on identifying whether the subject is at risk of exposure to SARS-CoV-2or infection with SARS-CoV-2. In other embodiments, the instructions include instructions to administer a composition comprising an inactivated SARS-CoV-2 vaccine to a subject at risk of exposure to SARS-CoV-2or infection with SARS-CoV-2.

The instructions associated with the use of a composition comprising an inactivated SARS-CoV-2 vaccine will generally include information regarding the dosage, schedule and route of administration of the intended treatment. The container may be a unit dose, a bulk package (e.g., a multi-dose package), or a sub-unit dose. The instructions provided in the kits of the invention are typically written instructions on a label or package insert (e.g., paper contained in the kit), but machine-readable instructions are also acceptable.

The kits of the invention are in suitable packaging. Suitable packaging includes, but is not limited to, vials, bottles, jars, flexible packaging, and the like. Packaging is also contemplated for use in conjunction with a particular device, such as a syringe or infusion device. The container may have a sterile access port, for example, the container may be a vial having a stopper pierceable by a hypodermic injection needle. At least one active agent in the composition is inactivated SARS-CoV-2, as described herein.

The invention is not limited in its application to the details of construction and the arrangement of components set forth in the following description or illustrated in the drawings. The invention is capable of other embodiments or of being practiced or carried out in various ways. Also, the phraseology and terminology used herein is for the purpose of description and should not be regarded as limiting. The use of "including," "comprising," or "having," "containing," "involving," and variations thereof herein, is meant to encompass the items listed thereafter and equivalents thereof as well as additional items.

Unless otherwise defined herein, scientific and technical terms related to the present disclosure shall have the meanings that are commonly understood by those of ordinary skill in the art. Furthermore, unless the context requires otherwise, singular terms shall include the plural and plural terms shall include the singular. The methods and techniques of the present invention are generally performed according to conventional methods well known in the art. Generally, the nomenclature and the techniques used in connection with biochemistry, enzymology, molecular and cellular biology, microbiology, virology, cell or tissue culture, and the genetics and protein and nucleic acid chemistry described herein are those well known and commonly used in the art. Unless otherwise indicated, the methods and techniques of the present disclosure are generally performed according to conventional methods well known in the art, and as described in various general and more specific references that are cited and discussed in the present specification.

The following examples further illustrate the invention but should in no way be construed as further limiting. All references cited in this application (including literature references, issued patents, published patent applications, and co-pending patent applications) are expressly incorporated herein by reference in their entirety, particularly for the teaching cited above. However, citation of any reference is not an admission that the reference is prior art.

Examples

Example 1 preparation of the drug

For the preparation of SARS-CoV-2, the JEV Process platform (Srivastava et al, vaccine 19 (2001) 4557-4565, US 6,309,650B1) was used as a basis, and improvements in methods suitable for purification of Zika virus were also contemplated, as disclosed in WO2017/109223A1 (which is incorporated herein in its entirety). Briefly, non-infectious SARS-CoV-2 particle aggregates, host cell proteins and other low molecular weight impurities are removed by protamine sulfate precipitation or benzoylase treatment, and the resulting preparation is optionally further purified by sucrose gradient centrifugation. See fig. 1 for an overview of the preparation process.

The first SARS-CoV-2 isolate from Italy was identified and characterized in the infectious disease institute "Lazzaro Spallianzani" IRCC in Roman national institute of Italy (accession No: MT 066156), the RNA sequence of which corresponds to the DNA sequence provided in SEQ ID NO 9, for all examples disclosed herein. Other novel isolates of coronavirus SARS-CoV-2 can also be obtained from:

1. EVAg (European Virus Archive), for example one of the following strains: betacoV/France/IDF0372/2020 (Ref-SKU: 014V-03890, https:// www. European-virus-archive. Com/virus/human-2019-ncov-0); 2019-nCoV/Italy-INMI1, (Ref-SKU: 008V-03893, SEQ ID NO; betaCoV/Netherlands/01 (Ref-SKU 010V-03903, https:// www.european-video-architecture.com/video/rs-cov-2-syntax-nl 2020)

2.-BEI Resources(Biodefense and Emerging Infections Research Resources):e.g.Isolate USA-WA1/2020,NIAID,NIH:SARS-Related Coronavirus 2,NR-52281(GenBank accession MN985325).

PHE (Public Health England): https:// www.gov.uk/goverment/concentrations/contacts-Public-Health-entry-regs-local-centrores-and-emergences: isolates of e.g. UK B.1.1.7 (UK _ MIG457: EVAg Ref-SKU:004V-04032 SEQ ID NO.

Vero cell line used in the methods described herein is the VERO (world health organization) cell line, from the general cell Collection of the health protection agencyThe master cell bank is generated from a centrally obtained catalog number 88020401. A SARS-CoV-2 research master seed pool (rMSB) was prepared on Vero cells (using 2019nCoV/Italy-INMI1 strain) and the genomic sequence was examined by sequencing. To prepare SARS-CoV-2, vero cells are grown in Eagle's Minimal Essential Medium (EMEM) containing 10% Fetal Bovine Serum (FBS) and monolayers infect SARS-CoV-2 at a fold infection (moi) of 0.001 to 1, preferably 0.01, per cell. After allowing virus adsorption, the cultures were washed 2-4 times with PBS, fed with serum-free EMEM, and 5% CO at 35 ℃% ₂ Incubate until the virus titer reaches the desired level.

SARS-CoV-2 harvest culture medium was harvested on days 2, 3, 5 and 7, and the harvests were pooled and centrifuged in a standard centrifuge. The resulting supernatant was filtered and then subjected to TFF ultrafiltration to remove cell culture media components and reduce batch volume. Reduction of host cell DNA and protein and reduction of non-infectious virus aggregates in the concentrated material is achieved by precipitation with protamine sulfate. Protamine sulfate was added to diafiltered SARS-CoV-2 material to reach a final nominal concentration of-2 mg/mL while stirring, followed by incubation at 2-8 ℃ for 30 minutes. Alternatively, the diafiltered SARS-CoV-2 material is treated with a benzoate enzyme.

SARS-CoV-2 virus is inactivated by direct treatment with beta-propiolactone after removal of virus-containing cell culture medium from Vero cells to render the virus safe for treatment with BSL 2. However, inactivation may be performed at any stage during the purification process, e.g. after centrifugation, before centrifugation and after centrifugation, during or after treatment with protamine sulfate or benzoate enzyme, or before or after sucrose gradient centrifugation. Inactivation by using a chemical inactivator such as formaldehyde (formalin); an enzyme; beta-propiolactone; ethanol; trifluoroacetic acid; acetonitrile; a bleaching agent; urea; guanidine hydrochloride; tri-n-butyl phosphate; an ethyleneimine or a derivative thereof; an organic solvent, optionally tween, triton, sodium deoxycholate or sulphobetaine; or a combination thereof. Particular preference is given to inactivation using beta-propiolactone, which preferentially targets viral RNA while relatively retaining the viral surface protein and its immunogenic epitopes. Inactivation may also be achieved by pH change (very high or very low pH), heat treatment or by irradiation (e.g. gamma irradiation or UV irradiation, especially UV-C irradiation). The SARS-CoV-2 virus is optionally inactivated by two separate inactivation steps, e.g., beta-propiolactone treatment and UV-C irradiation.

To preliminarily support our proposed SARS-CoV-2BPL inactivation procedure, a preliminary study was conducted to evaluate the kinetics of PPV virus inactivation. Porcine Parvovirus (PPV) was selected as a model virus to evaluate the inactivation capacity of BPL in aqueous solution because it is highly resistant to physicochemical inactivation. Three starting concentrations of BPL were evaluated: 300ppm (1/3333), 500ppm (1/2000) and 700ppm (1/1429). BPL at these concentrations was added to the virus solution and incubated at 5. + -. 2 ℃ for 24 hours. Kinetic samples were taken after 0.5, 2, 6, 24 hours and BPL hydrolysis steps and analyzed for remaining infectivity. The results are shown in Table A.

* Is lower than the detection limit

* Injecting: the detection limit of 500ppm BPL is lower than 700ppm BPL

After 24 hours of incubation at 5. + -. 2 ℃ before hydrolysis, a clear effect of the initial BPL concentration on the inactivation efficiency was observed, decreasing between 3.3 and 5.9log 10. The subsequent hydrolysis step further reduced the titer by the average addition of 1.7log10, while keeping the control titer constant throughout the process. This indicates that the hydrolysis step can be used as an additional inactivation step for highly resistant viral contamination. In case of a total reduction factor of 4.84 (300 ppm), 7.43 (500 ppm) and below the detection limit (700 ppm), the applied BPL treatment is considered to be effective for inactivation of parvoviridae at concentrations >300 ppm. Therefore, we decided to select 500ppm for SARS-CoV-2 virus inactivation in all further studies.

BPL inactivated SARS-CoV-2 virus

Based on the existing data for BPL inactivation model viruses (see section above for PPV inactivation), BPL concentrations of 500ppm (1/2000) were selected for inactivation of SARS-CoV-2 virus harvest material. Since the stability of BPL in solution is highly temperature dependent, an incubation temperature of 5 ± 3 ℃ and an incubation time of 24 hours were chosen to ensure that sufficient BPL was present throughout the inactivation process. After adding and mixing BPL in the concentrated harvest, the inactivation solution was transferred to a fresh vessel and inactivation was performed under controlled conditions. This transfer excludes the possibility of viral particles in potential dead spots that do not contact the BPL during initial mixing.

To stabilize the pH of the inactivated virus solution during BPL hydrolysis, 25mM HEPES pH 7.4 was added to the concentrated harvest pre-cooled to 5 ± 3 ℃.

To reduce the BPL remaining after inactivation, the solution was heated to a temperature above 32 ℃ for a total time of 2.5 hours ± 0.5 hours in a temperature controlled incubator set at 37 ± 2 ℃. When the current process volume is about 1L, the total time of the hydrolysis step is between 5 hours 15 minutes and 6 hours 15 minutes, including warming to above 32 ℃ and incubation.

Immediately after the hydrolysis was completed, the Inactivated Virus Solution (IVS) was cooled to 5 ± 3 ℃ in a temperature-controlled refrigerator and stored in the refrigerator until inactivation was confirmed by the high-volume plaque assay and serial passage assay, which currently takes 18 days in total. Recovery of viral particles throughout the inactivation process was monitored by size exclusion chromatography.

Preliminary studies at laboratory scale from 15 mL to 1000 mL showed that SARS-CoV-2 has very rapid inactivation kinetics, where viral titers of up to 8log10pfu/mL fall below detectable levels within 2 hours after addition of BPL. These results were confirmed in a GMP production run with a final inactivation volume of about 1L. In conjunction with inactivation data for model viruses, the applied BPL treatment can be considered effective and includes a significant safety margin for inactivation of SARS-CoV-2 concentrated harvested material.

In another preferred embodiment, the inactivation step is particularly gentle to preserve the integrity of the surface antigens, in particular the integrity of the S protein. In one embodiment, the mild inactivation method comprises contacting a liquid composition comprising SARS-CoV-2 particles with a chemical viral inactivating agent (e.g., any of the chemical inactivating agents described above or a combination thereof, preferably beta-propiolactone) in a vessel, mixing the chemical viral inactivating agent and the liquid composition comprising SARS-CoV-2 particles under conditions of laminar flow rather than turbulent flow, and incubating the chemical viral inactivating agent and the liquid composition comprising SARS-CoV-2 particles for a time sufficient to inactivate the virus. The mild inactivation step is optionally performed in a flexible bioreactor bag. The mild inactivation step preferably comprises five or fewer container inversions during inactivation. Preferably, mixing of the chemical virus-inactivating agent and the composition comprising SARS-CoV-2 particles comprises shaking, rotating, orbital shaking, or oscillating the container at a speed of no more than 10rpm for no more than 10 minutes during the incubation.

Purification of SARS-CoV-2, optionally, immediately with Capto ^TM The Core 700 or CC40 chromatography media further treated the material by batch adsorption (also referred to herein as batch chromatography) at a final concentration of about 1% CC700 or CC 400. The material was incubated at 4 ℃ for 15 minutes with constant stirring using a magnetic stirrer. After incubation, if a CC700 or CC400 solid material is used, it is allowed to settle by gravity for 10 minutes and SARS-CoV-2 material is removed from the top of the solution to avoid clogging the filter with CaptoCore particles. Any remaining CaptoCore particles and DNA precipitate were then removed from the solution by filtration using a 0.2 μm Mini Kleenpak EKV filtration capsule (Pall). The combined filtered harvest material was adjusted to a final concentration of 25mM Tris pH 7.5 and 10% sucrose (w/w) using a two-component stock solution. This allows the concentrated harvest to be frozen in if desired<-65℃。

The resulting filtrate was further processed by sucrose density gradient centrifugation (also referred to herein as batch centrifugation) to finally concentrate and polish the SARS-CoV-2 material. Concentrated Protamine Sulfate (PS) or benzoate (most preferably PS) treated harvest was loaded on a solution consisting of three layers of sucrose of different densities. The volume of each layer centrifuged in a 100 ml flask is shown in table 1 a.

TABLE 1a volume of sucrose density centrifugation

Sucrose solution (w/w)	Volume (mL)
		PS-treated SARS-CoV-2 harvest (10% sucrose)	40
15% sucrose	15
		35% sucrose	15
50% sucrose	20
		Total volume	90

Sucrose gradient vials were prepared by layering individual sucrose layers by pumping the solution into the bottom of the vial, first the SARS-CoV-2 material with the lowest sucrose density (10% sucrose (w/w)), and then the other sucrose solutions, in ascending order. The arrangement is shown in figure 3. The prepared SG bottles were transferred to a rotor, pre-cooled to 4 ℃, and centrifuged at-11,000rcf max at 4 ℃ for at least 20 hours without braking/deceleration.

After centrifugation, serial 2ml fractions of sucrose gradient were harvested from bottom to top with a peristaltic pump. These fractions were immediately tested by SDS-PAGE/silver staining to identify virus-containing fractions of sufficiently high purity. Thus, the identified fractions were pooled and further processed. Purified SARS-CoV-2 was stored at < -65 ℃ or immediately formulated.

SARS-CoV-2 preparation with adjuvant and SARS-CoV-2 granule prepared with alum. Optionally, a Th1 adjuvant is also added to the formulation or provided as a separate composition for bedside mixing.

SARS-CoV-2ELISA detection. The content of inactivated SARS-CoV-2 antigen (i.e., the content of S1 as the main antigenic protein) in the preparations described herein was determined (quantified) by ELISA. As used herein, SARS-CoV-2ELISA is a four-layer immunoenzyme assay in which the SARS-CoV-2 spike antibody (AM 001414; envelope antibody) is immobilized on a microtiter plate to which a SARS-CoV-2 sample is added. After binding of antigen to envelope antibody, primary antibody (i.e., antibody)

SARS-COV-2 spike antibody (rAb) (AM 002414)) further processed the plate. A secondary antibody, which is an enzyme-linked conjugated antibody (i.e., goat anti-mouse IgG-HRP conjugate), is then added. The plates were washed between the different steps using a mild detergent solution (PBS-T) to remove any unbound protein or antibody. The plate was developed by adding a Tetramethylbenzidine (TMB) substrate. The hydrolyzed TMB forms a stable colored conjugate that is proportional to the concentration of the antigen content in the sample. Antigen quantification was performed by spectrophotometric detection at λ 450nm (λ 630nm reference), using standard curves generated in an automatic plate reader as reference. Standards were prepared starting from a peak trimer pure working solution of 20 Antigen Units (AU)/mL, which was further serially diluted at a ratio of 1 to 2 to achieve the following standard concentrations: 20AU/mL, 10AU/mL, 5AU/mL, 2.5AU/mL, 1.25AU/mL, 0.625AU/mL, 0.3125AU/mL, and 0.1263AU/mL. Two experiments were performed per dilution per plate. According to the supplier (R)&D Systems), the "antigenic unit" of the spiking trimer standard corresponds to its binding capacity in a functional ELISA with recombinant human ACE-2 His-tag.

Reference standard and antibody:

envelope antibody SARS-CoV-2 spike antibody (AM 001414)

Spike trimer (S1 + S2), his-tag (SARS-CoV-2) (e.g., BPS Lot #200826, cat #, 100728)

SARS-CoV-2QC (Label RSQC240920 AGR)

First order detection antibodies

SARS-CoV-2 spike antibody (rAb) (AM 002414)

Goat anti-mouse IgG HRP conjugate as secondary detection antibody

Coating buffer solution: carbonate buffer

ELISA wash buffer PBS +0.05% Tween-20 (PBS-T).

Sample dilution buffer PBS-T +1% BSA.

The preparation process delivered high density and intact spike protein (see fig. 6). Estimated at about 1 to 1.5x 10 per AU ⁷ And (c) viral particles. The inactivation process of beta-propiolactone provides rapid kinetics of inactivation and no chemical modification of the S protein was detected. Key parameters and related process related impurities and commercial use

The production process is similar (see table 1 b). According to SDS-PAGE (silver staining, reduction), the SARS-CoV-2 drug substance of the present invention is of high purity: (>95%) and, according to SE-HPLC, no aggregates (monomeric virus: (S) ((S))>95%) (see fig. 7).

Further validation studies aimed at characterizing the modification of the S protein after inactivation of SARS-CoV-2 by beta-propiolactone by mass spectrometry of tryptic digest of the S protein. Amino acid modifications in important epitopes are rare. Initial alignment of the S proteins and Receptor Binding Domains (RBDs) within the hACE2 interface of some known (cross-) neutralizing antibodies (SARS-CoV and SARS-CoV-2) indicates that none of these epitopes have potentially high conversion rates and only a few amino acids have potentially lower conversion rates.

TABLE 1b. SARS-CoV-2 drug substance and

comparison of key parameters of drug substances and related process-related impurities.

Example 2in vitro and in vivo evaluation of immunogenicity and protective Capacity of inactivated SARS-CoV-2 Virus compositions

Immunogenicity prior to immunization, an experimental group of 10 Balb/c mice was bled and preimmune serum was prepared. Mice were injected subcutaneously with a dose of inactivated SARS-CoV-2 titrant formulated with alum (see Table 2). At two different time intervals after immunization (see below), blood was collected and immune sera prepared, and spleens were collected at the last bleeding. All animal experiments were carried out according to the Austria law (BGB 1, no. 501/1989) and approved by "Magistarabteiung 58". Serum total IgG and subclasses (IgG 1/IgG2 a) were assessed by ELISA and neutralizing antibodies by PRNT. Th1/Th2 responses were further assessed by FN- γ ELISpot and intracellular cytokine staining (CD 4+/CD8 +).

-attached table 1: day 0/7 of immunization, day 14 of intermediate bleeding, day 28 of final bleeding and spleen harvest

-attached table 2: immunization on day 0/day 21, temporary bleeding on day 14/day 28, final bleeding and spleen Collection on day 35

Table 2. Dose experimental design, 10 mice/group: 3 dose groups: 0.2-2 μ g total protein; the number of experiments: 3. for experimental purposes, th1 adjuvant was added directly to the SARS-CoV-2/alum formulation prior to immunization of mice.

Plaque Reduction Neutralization Test (PRNT) each well of a 12-well tissue culture plate was seeded with Vero cells and 5% CO at 35 ℃ ₂ Incubate for three days. Serial dilutions of heat-inactivated serum pools from each treatment group were tested. Mixing each bloodThe clear preparation is mixed with SARS-CoV-2 at about 50-80pfu at 35 ℃ and 5% CO ₂ Incubate for 1 hour. Cell culture medium was aspirated from Vero cells and SARS-CoV-2/serum mixture was added to each well. The plate was gently shaken and then treated with 5% CO at 35 deg.C ₂ Incubate for 2 hours. Adding 1ml of a 2% methylcellulose solution containing EMEM and nutrients to each well and 5% CO at 35 ℃% ₂ The plates were further incubated for 4 days. The cells were then stained with crystal violet/5% formaldehyde for 1 hour and washed 3 times with deionized water. The plates were air dried and the number of plaques in each well was counted manually. Alternatively, other methods may be applied, such as TCID ₅₀ . Table 3 schedule and life test design, 10 mice/group; the immunization schedule is shown in table 2, but is not included; temporary bleeding occurred 2, 6, 10, 14, 18 and 22 weeks after the second immunization; bleeding ended 26 weeks after secondary immunization; only the preferred dose is used; the subcutaneous route only; the number of experiments: 1. for experimental purposes, th1 adjuvant was added directly to the SARS-CoV-2/alum formulation prior to immunization of mice.

Protective Capacity the protective capacity of inactivated SARS-CoV-2 was assessed using a SARS-susceptible Transgenic mouse expressing a humanized ACE2 protein (Jackson Laboratory) (Tseng, C. -T.K.et al, severe acid responsive synergy Coronavir Infection of Rice transforming for the Human Angiotensin-Converting Enzyme 2Virus Receptor (2007) J of Virus 81: 1162-1173) or an NHP model developed for SARS-CoV-2. Various groups of animals were immunized subcutaneously (s.c.) with different doses of inactivated SARS-CoV-2, whether adjuvant or PBS was used as a negative control. Three weeks after the last dose, animals were challenged with SARS-CoV-2 and disease progression and survival were monitored. In addition, serum samples were taken to determine neutralizing antibody titers induced by vaccination in the PRNT assay.

TABLE 3A dosing experiment 4743 using the SARS-CoV-2ELISA for determination of the dose.

Experimental 4743 protocol female Balb/c mice (10 mice/group) were immunized twice (100 μ L) at day 0 and day 21 with the doses and adjuvants s.c. listed in table 3A. The readings for the experiment were total IgG and subclass (IgG 1/IgG2 a) and virus neutralization (PRNT). Vaccine formulation used in experiment 4743: purified inactivated SARS-CoV-2 prepared from the research Virus seed Bank (rVSB) at 17. Mu.g Al in PBS ³⁺ (alum)/dosage formulation.

Antibody response to SARS-CoV-2 protein the immune response of mice to different doses and adjuvant formulations was evaluated using a total IgG ELISA (FIG. 4). Plates were coated with the S1 portion of the spike glycoprotein or nucleoprotein (fig. 4A) or Receptor Binding Domain (RBD) (fig. 4B) (fig. 4C). Sera collected on day 28 and day 35 were analyzed. Plates were coated with 2 μ g/mL antigen (S1, RBD and N protein) and mouse sera were tested at the initial dilution of 1. For detection, a secondary monoclonal antibody (HRP-conjugated goat anti-mouse IgG) was used and developed with ABTS and read at absorbance 405 nm. Wells were washed with PBS-T between each step. The end-point titer was determined with a cut-off value of 3 times the blank.

Plates were coated with a spike glycoprotein from the S1 moiety (fig. 4A) and sera collected on day 35 were analyzed. Detection was performed using subclass-specific secondary antibodies (IgG 1 and IgG2 a) that bind to HRP. As a standard curve (4-parameter regression) for determining the number of different IgG subclasses (IgG 1 and IgG2 a), monoclonal antibodies with different subclasses (IgG 1 mAb clone 43 and IgG2a mAb clone CR 3022) were used. Conjugated HRP-conjugated secondary monoclonal antibodies were developed with ABTS and read at absorbance 405 nm. Wells were washed with PBS-T between each step. The relative IgG subclass concentrations are shown in FIG. 5A, and the IgG2a/IgG1 ratios are shown in FIG. 5B.

Inactivation of SARS-CoV-2in mice formulated with Alum-induced antibodies SARS-CoV-2 was detected by measuring antibodies to the S1 protein, receptor Binding Domain (RBD) and nucleocapsid protein (N) by ELISA (FIGS. 4A-C). An increase in immunogenicity was observed between bleeding on day 28 and day 35. In the group receiving the lowest dose (0.3 AU), the increase in S1 and RBD ELISA titers was small but not significantly higher than placebo.

Compared to the Th1 (IgG 2 a) response, alum-adjuvanted SARS-CoV-2 promoted the shift of the immune response to Th2 (IgG 1) as expected, as demonstrated by quantification of the IgG subclass by S1 ELISA. The measured total amounts of IgG2a and IgG1 and the ratio of IgG2a to IgG1 in the treatment groups are shown in FIGS. 5A and 5B, respectively. By adding a Th1 stimulating adjuvant to a SARS-CoV-2 vaccine composition, a shift in the immune response to Th1 (IgG 2 a) can also be expected.

Further immunization experiments were performed in mice using low doses (3, 1.2 and 0.3 AU) of GMP material as a bridge between study and GMP material, and human doses (40, 10 and 3 AU) were analyzed.

In addition, challenge studies were performed in immunized non-human primates (NHPs) (see FIG. 8) and passive transfer studies were performed in hamsters using sera from human subjects vaccinated with the SARS-CoV-2 candidate vaccine of the present invention (see Table 1 c).

TABLE 1c Passive transfer study of SARS-CoV-2 candidate vaccine of the present invention in hamster

Example 3 antibody dependent disease enhancement (ADE) and immunopathology testing of SARS-CoV-2 vaccine

Although the mechanism is poorly understood, antibodies raised against prior coronavirus infections or vaccinations may increase the risk of 1) immunopathology and/or 2) antibody-dependent disease enhancement (ADE) during subsequent coronavirus infection. Thus, any stimulation of SARS-CoV-2 antibody is a hypothetical risk. In this regard, several approaches have been taken to ensure the safety of current vaccines.

In vitro evaluation of immune sera from inactivated SARS-CoV-2 immunized mice for the enhancement of disease characteristics. Such assays are described, for example, by Wang, S. -F., et al.2014 (Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins (2014) BBRC 451. Briefly, a susceptible cell type or cell line is incubated with immune serum and then infected with SARS-CoV-2. Assessing cytopathic effects and/or production of inflammatory markers.

Mouse Immunopathology models the risk of vaccine-enhanced Immunopathology at Challenge was assessed in a Balb/c mouse model as described by Tseng C.T.et al (Immunization with SARS Coronavir viruses Leads to Pulmonary Immunopathology on Challenge with the SARS Virus (2012) PLoS ONE 7 (4): e 35421). Briefly, mice were immunized twice every two weeks with inactivated SARS-Cov-2 (formulated as described herein) and then challenged with SARS-Cov-2. SARS-Cov-2 titers and immune cell infiltration of the lung were tested.

Non-human primate models of ADE the risk of ADE development in non-human primates was assessed as described by Luo F, et al (Evaluation of Antibody-Dependent Enhancement of SARS-CoV Infection in Rhesus Macaques Immunized with an Inactivated SARS-CoV Vaccine (2018) virology Sinica 33. Briefly, NHPs were immunized with inactivated SARS-CoV-2, followed by SARS-CoV-2 challenge and symptom and disease pathology assessments.

Example 4 clinical phase 1 study

Inactivated SARS-CoV-2 preparation for phase 1 assay the purpose of the phase 1 assay is to assess the safety and immunogenicity of the vaccine and to determine the optimal dose and adjuvant. Therefore, three antigen doses were tested in clinical stage 1: high, medium, low, with a distance between each dose of about 3 times and a span of about 10 times between the high and low doses. The dose range was chosen in part to indicate any potential dose-sparing effect of the Th1 adjuvant.

The SARS-CoV-2 virus purified herein was of >90% high purity as assessed by SDS-PAGE, SE-HPLC and/or SARS-CoV-2ELISA (data not shown). In addition, preliminary studies showed that the incidence of genetic heterogeneity during viral transmission was low, with no specific individual mutations (data not shown).

The SARS-CoV-2 virus purified herein has a high purity of >90% as assessed by SDS-PAGE, SE-HPLC and/or SARS-CoV-2ELISA (see e.g., FIG. 7). In addition, preliminary studies showed that the incidence of genetic heterogeneity during viral transmission was low, with no specific individual mutations (data not shown).

To achieve a certain dose range, SARS-CoV-2 virus was compared with JEV, in particular the SE-HPLC peak area per dose equivalent (recorded as milliabsorbance units x min; mAU), the total amount of inactivated virus particles per dose and the total virus surface equivalents per dose were evaluated (see Table 4). The assessment is based on the assumption of similar surface antigen density between S (spike; SARS-CoV-2) and E (envelope; JEV) proteins. Total protein was determined by μ BCA assay (table 4). Although the assay method was variable, about 2 μ g total protein per ml of 1 mAU was observed. Another assay was also performed using the optimized SARS-CoV-2S protein ELISA as described in example 1.

TABLE 4 JEV and SARS-CoV-2 quantification parameters and Total protein for the lower, medium and high dose groups

Since SARS-CoV-2 virus particles (about 92nm in diameter) are much larger than flavivirus particles (about 40 nm), the virus surface area corresponding to each particle is about 5 fold, and thus the antigen content is expected to be quite high. In addition, other inactivated virus vaccine formulations, including JEV (IXIARO), TBE (encapur) and HepA (VAQTA), reported antigen doses in the low μ g to ng protein range. Since these viruses are all formalin inactivated, the BPL inactivated SARS-CoV-2 virus of the invention has better preserved surface antigen proteins, i.e., better quality antigens, and requires lower total protein doses.

To enter the clinic, another antigen assay (SARS-CoV-2 ELISA assay as described in example 1) was developed and used to determine the dose of vaccine formulation entering the phase 1 trial. Table 5 lists the stage 1 treatment group.

SARS-CoV-2 vaccine formulation for phase 1 assay (0.5 ml/dose):

target dose of antigen (inactivated SARS-CoV-2)：

Low: 3AU/0.5mL (6 AU/mL). Times

The method comprises the following steps: 10AU/0.5mL (20 AU/mL)

High: 40AU/0.5mL (80 AU/mL)

* The dose was determined by SARS-CoV-2ELISA assay as described in example 1

³⁺ Aluminum hydroxide (Al)): 0.5 mg/dose (1 mg/ml)

-Th1 adjuvant

Recombinant human serum albumin (rHSA): 25 mug/dose (50 mug/mL)

-buffer solution: phosphate Buffered Saline (PBS)

In some cases, vaccinated subjects are challenged with infectious doses of live SARS-CoV-2 virus (Asian and/or European lineage).

TABLE 5 inactivated SARS-CoV-2 vaccine phase 1 tested treatment group (low, medium, high doses see Table 4).

Example 5 serum from inoculated organisms tested by neutralization assay

Sera from vaccinated mice, hamsters, non-human primates or humans can be tested in neutralization assays as described in "Szurgot, I., hanke, L., sheward, D.J.et. Al. DNA-launched RNA replenisher vaccines in mice, sci. Rep 11,3125 (2021) https:// doi.org/10.1038/s 41598-021-82498-5".

The test results indicate how well the vaccinated subjects neutralized the new variation in serum, thus guiding the design of the vaccine.

Example 6 liquid chromatography-tandem Mass Spectrometry (LC-MS-MS) analysis of inactivated SARS-CoV-2The method comprises the following steps:

the two samples were separated using SDS-polyacrylamide gel electrophoresis and bands were visualized by silver staining. The bands were cleaved and digested in gel with trypsin and the resulting peptides were analyzed by nano-liquid chromatography combined with high resolution precision mass spectrometry. Peptides were identified from the raw spectra using the MaxQuant software package and the UniProt reference database for SARS-CoV-2 and Chlorocebus sabaeus. To explain the modifications, a re-search for β -propiolactone modifications was performed exclusively on the data and the results obtained were confirmed using a second independent search algorithm (sequence in protein resolver suite). In addition, the data was searched using the FragPipe software package to account for further unknown MS detectable modifications.

As a result:

protein identification:

these bands can be unambiguously assigned to three major viral proteins (spike-protein, membrane-protein, nucleoprotein) as well as to background proteins from the host system (see fig. 10). Traces of SARS-CoV-2ORF9b and the replicase polyprotein can also be detected, but due to their size these proteins may not be well resolved on the gel. The gel separation patterns of the two samples were very similar, except for the host protein band (band 2.3), the slightly different S protein pattern (bands 2.10-2.13), and the expected serum albumin band in one of the samples (sample 2). In addition, many typical laboratory contaminants of human origin (such as keratin) were detected in the background of both samples. Spike-protein processing (from full length to S1, S2 and S2') is difficult to solve with the applied method, but is likely represented by the pattern in bands 9-13 in both samples.

Modification analysis:

according to Uitenboaard et al (Reactions of beta-Propiolactone with nucleozyme analogs, nucleotides, and Peptides, protein Structure and Folding | Volume 286, ISSUE 42, P36198-36214, october 21, 2011), it is expected that beta-Propiolactone (BPL) will be found to modify cysteines, methionine and histidine. Uitenbagaard et al investigated amino acids modified by beta-propiolactone, as well as the types of modifications, such as acylation, alkylation. They have demonstrated that BPL can react with up to 9 different amino acids (C, H, M, D, E, Y, K, E, S) depending on the actual pH. In their studies, higher conversion of cysteine (> 95%), histidine (15-25%) and methionine (36%) residues was observed in the relevant pH range. The conversion of aspartate, glutamate and tyrosine was much lower in the range of about 3-15%. The results show that the disulfide groups in the cystine residues are not reacted.

In BPL inactivated SARS-CoV-2 particles, BPL modification (mainly in the form of +72 Da) can be detected, but in lower abundance. In the SARS-CoV-2 protein spectra identified at 2894 (sample 1) and 3086 (sample 2), only 73 and 110 carry BPL modifications, respectively, which convert to 2.5 to 3.6% (see Table 6). This was also confirmed using an open embellishment search of FragPipe, which attributed a similarly low portion of the spectrum to the difference in quality of matching BPL embellishments.

TABLE 6 number of SARS-CoV-2 peptide spectra identified

Sample(s)	Total spectrum of light	BPL spectrum	% modification
				Sample
1	2894	73	2.5％
				Sample
2	3086	110	3.6％

Total Spectrum the spectra of all reported BPL modified peptides of the SARS-CoV-2 protein were examined manually, with samples 1 and 2 identifying 6 to 8 sites, respectively (see Table 6). For all these validation sites, unmodified peptides were also identified, indicating that BPL modification never reached 100%. We estimate the degree of modification at a particular site (so-called site occupancy) as the ratio of modified to unmodified peptides at the same modification site, normalized to the protein abundance per band. We then chose the maximum occupancy of each site as a conservative measure of the extent of modification of the site. As shown in table 7, the occupancy of the identified sites was generally low, consistent with the total number of identified spectra. The only exception is M234 of the nucleoprotein, which must be carefully interpreted, since this particular peptide sequence has problematic characteristics, and the estimation of this particular peptide may be less accurate and reliable than other sites.

TABLE 7 determination of BPL modification sites and their occupancy rates

Protein	Position of the site	% occupancy sample 1	% occupancy of sample 2
				Spike-protein	H207	<0.1％	16％
Spike-protein	H245		1％					3％
				Spike-protein	C379	<0.1％	n.d.
Spike-protein	M1029	<0.1％	<0.1％
				Spike-protein	C1032	<0.1％	n.d.
Membrane proteins	H154	<0.1％	<0.1％
				Membrane proteins	H155	1％	1％
Membrane proteins	C159	n.d.	<0.1％
				Membrane proteins	H210	5％	6％
Nucleoproteins	M234	<0.1％	88％*

n.q. = unquantized; n.d. = undetected

* Due to deletion of cleavage and oxidation, the quantification is uncertain

In addition to the expected modifications, the franpipe search found two additional modifications (most likely acetaldehyde and acetylation) that occurred in about 10% of the spectrum. These modifications represent the most likely artifacts introduced during gel staining and sample preparation, as they also occur on contaminating proteins.

To summarize:

based on the above results, it can be concluded that the major component in these samples corresponds to SARS-CoV2 protein. BPL modification was detectable, but appeared to be very low, i.e., about 3% at the level of the entire SARS-CoV-2 proteome (i.e., all SARS-CoV-2 proteins identified). Only 5 amino acids of the S protein were found to be modified and this was also detected only in a few S proteins analyzed (e.g., the spike at amino acid H207-protein was about 16%, i.e., the probability of modification at H207 was about 16%). These two samples differed only slightly in some background proteins and degree of modification, with sample 1 showing a slightly lower level of BPL modification. Note that only about 30% to 40% of spiking amino acids can be tested.

And (4) conclusion:

this data supports the notion that the mild inactivation method of the present invention minimizes the modification within the S protein, so that the native surface of the S protein is substantially preserved.

In contrast, the modifications were determined more frequently by BPL inactivation of influenza samples, i.e. modifications: there are 83 sites on HA and 43 sites on NA for one sample of influenza vaccine (NIBRG-121 xp) and 99 sites on HA and 39 sites on NA for another sample (NYMC-X181A), where HA and NA are the two major membrane glycoproteins, the major immunogens of influenza (She Yi-Min et al, surface modifications of influenza proteins inactivation by virus inactivation by beta-propuloctone; proteomics 2013,13,3537-3547, DOI10.1002/pmi.201300096). Thus, BPL inactivation of influenza viruses can result in a number of protein modifications, including some that affect membrane fusion.

Example 7 further liquid chromatography-tandem Mass Spectrometry (LC-MSMS) analysis of inactivated SARS-CoV-2

The method comprises the following steps:

BPL-inactivated SARS-CoV-2 particles were further subjected to LC-MSMS analysis as described in example 6 to obtain greater protein coverage. Five aliquots of BPL-inactivated SARS-CoV-2 samples were separated on SDS-PAGE and bands visualized by silver staining or Coomassie staining treatment. Coomassie staining bands corresponding to the spike proteins (based on previous analysis) were subjected to in-gel digestion or acid hydrolysis with trypsin or chymotrypsin. Trypsin digestion was performed in two runs, one with PNGase F (peptide: N-glycosidase F) and one without, to identify peptides masked by glycosylation.

The digested peptides were analyzed by LC-MSMS essentially as described in example 6. In particular, the resulting peptides were analyzed using nano-liquid chromatography coupled to a high resolution precision mass spectrometer. Peptides were identified from raw spectra using the MaxQuant software package and UniProt reference database for SARS-CoV-2 and Chlorocebus sabaeus in combination with the common laboratory contaminants database. To explain the modifications, the data were also specifically searched for β propiolactone (BPL) modifications, and the spectra of all BPL-modified peptides of the SARS-CoV-2 spike protein were manually validated. The degree of modification was estimated globally as a percentage of the BPL modification spectrum identified and occupancy of sites was calculated by calculating the ratio of modified to unmodified peptide for each peptide/site separately.

As a result:

using a combination of four digestion methods (i.e., (i) trypsin (ii) trypsin + PNGase F (iii) chymotrypsin and (iv) acid hydrolysis), the overall coverage of a particular SARS-CoV-2 protein is as follows:

peak (S) protein-91.5%

Membrane (M) protein-60.36%

Nucleoprotein (N) -74.70%

The amount of BPL-modified peptide in inactivated SARS-CoV-2 particles based on each digestion method is shown in Table 8 below:

TABLE 8 number of SARS-CoV-2 peptide profiles identified in all bands analyzed

Sample (I)	General assembly	BPL modification	% BPL modification
				Trypsin	3148	97	3.1％
Trypsin + PNGase F	2354	61	2.6％
				Chymotrypsin
	2753	174	6.3％
				Acid hydrolysis	939	33	3.5％
General assembly	9194	365	4.0％

As shown in example 6, this demonstrates that the percentage of BPL-modified peptide is low, e.g., on average less than 7%, 2-7%, or about 2-5%, regardless of the digestion method used.

Using a combination of the four digestion methods described above, greater coverage of amino acid residues within the SARS-CoV-2 protein can be achieved. Thus, BPL modification was detected at the positions of the peak (S) protein and membrane (M) protein shown in table 9 below. As described in example 6 above, the average occupancy for each site is also shown in table 9.

TABLE 9 BPL modification sites identified in the S protein and their occupancy

Protein	Position of the site	% occupation
			Spike-protein	H49		1％
Spike-protein	H146						2％
			Spike-protein	C166		1％
Spike-protein	M177						6％
			Spike-protein	H207		1％
Spike-protein	H245						13％
			Spike-protein	C432	8％
Spike-protein	H519					2％
			Spike-protein	H625	7％
Spike-protein	M1029					2％
			Spike-protein	H1058	11％
Spike-protein	H1083					3％
			Spike-protein	H1088			4％
Spike-protein	H1101					1％
			Spike-protein	H1159			4％
Spike-protein	H1271					1％
			Membrane proteins	H125	<10％
Membrane proteins	H154	<10％
			Membrane proteins	H155	<10％
Membrane proteins	H210	<10％

As can be seen from the data in table 9, up to 16 residues in the spike (S) protein can be modified and up to 4 residues in the membrane (M) protein. Occupancy per site is low, e.g. below 20%, typically below 10%. Thus, inactivated SARS-CoV-2 particles show a lower degree of BPL modification.

Additional aspects of the invention

In other aspects, the invention provides:

A1. a SARS-CoV-2 vaccine, comprising optimally (e.g., wherein the native surface of the S protein is retained) inactivated SARS-CoV-2 particles, wherein the SARS-CoV-2 particles are capable of serotransforming a subject administered the SARS-CoV-2 vaccine with at least 70% probability.

A2. The SARS-CoV-2 vaccine of aspect A1, wherein the SARS-CoV-2 particle is capable of seroconverting a subject administered the SARS-CoV-2 vaccine with a probability of at least 80%, 85%, 90%, or 95%.

A3. The vaccine of aspect A1 or A2, wherein the SARS-CoV-2 particle has an RNA genome corresponding to a DNA sequence provided by any one of the following nucleic acid sequences:

1 (see Genbank NC-045512.2) or a variant nucleic acid sequence which is at least 85% identical to SEQ ID NO. 1 and which is capable of encapsulating a virulent SARS-CoV-2; or

9 (see NCBI MT 066156) or a variant nucleic acid sequence of SARS-CoV-2 which is at least 85% identical to SEQ ID NO. 1 and is capable of encapsulating virulence; or

18 (see NCBI MW 598408) or a variant nucleic acid sequence which is at least 85% identical to SEQ ID NO 18 and which is capable of encapsulating a virulent SARS-CoV-2; or

20 (see NCBI MW 520923) or a variant nucleic acid sequence which is at least 85% identical to SEQ ID NO 20 and which is capable of encapsulating a virulent SARS-CoV-2; or

22 (see NCBI MW 422256) or a variant nucleic acid sequence which is at least 85% identical to SEQ ID NO. 22 and which is capable of encapsulating a virulent SARS-CoV-2; or

24 (see NCBI MW 493681) or a variant nucleic acid sequence that is at least 85% identical to SEQ ID NO:24 and is capable of encapsulating a virulent SARS-CoV-2; or

26 (see NCBI MW 306426) or a variant nucleic acid sequence of SARS-CoV-2 which is at least 85% identical to SEQ ID NO 26 and is capable of encapsulating virulence.

A4. The vaccine of any one of aspects A1-A3, wherein the SARS-CoV-2 particle has an S protein defined by the following amino acid sequence:

3 or a variant amino acid sequence of SARS-CoV-2 which is at least 95% identical to SEQ ID NO 3 and is capable of encapsulating virulence; or

11 or a variant amino acid sequence of SARS-CoV-2 which is at least 95% identical to SEQ ID NO 11 and is capable of encapsulating virulence; or

19 or a variant amino acid sequence of SARS-CoV-2 which is at least 95% identical to SEQ ID NO 19 and is capable of encapsulating virulence; or

21 or a variant amino acid sequence of SARS-CoV-2 which is at least 95% identical to SEQ ID NO 21 and is capable of encapsulating virulence; or

23 or a variant amino acid sequence of SARS-CoV-2 which is at least 95% identical to SEQ ID NO 23 and is capable of encapsulating virulence; or

25 or a variant amino acid sequence of SARS-CoV-2 which is at least 95% identical to SEQ ID NO 25 and is capable of encapsulating virulence; or

27 or a variant amino acid sequence of SARS-CoV-2 which is at least 95% identical to SEQ ID NO 27 and is capable of encapsulating virulence; or

A4.1 aspect of any one of A1-A4, comprising a second SARS-CoV-2 particle different from the first SARS-CoV-2 particle and selected from SEQ ID NOs 1, 9, 18, 20, 22, 24 and 26.

A5. The vaccine of any one of aspects A1-A4 and a4.1, wherein SARS-CoV-2 is inactivated by chemical inactivation, heat inactivation, pH inactivation, uv inactivation, or radiation inactivation.

A6. The vaccine of aspect A5, wherein the chemical inactivation comprises contacting the SARS-CoV-2 particle with a chemical inactivator for a time period longer than the time required to completely inactivate SARS-CoV-2, as determined by plaque assay or by plaque assay plus one day.

A7. The vaccine of aspect A6, wherein the chemical inactivation comprises contacting the SARS-CoV-2 particles with formaldehyde and/or beta-propiolactone, preferably beta-propiolactone.

A8. The vaccine of aspect A7, wherein the formaldehyde and/or beta-propiolactone inactivation comprises contacting SARS-CoV-2 particles with formaldehyde and/or beta-propiolactone for 2-10 days.

A9. The vaccine of any one of aspects A5-A8, wherein the chemical activation is performed at about 4 ℃ or about 22 ℃.

A10. The vaccine of any one of aspects A1-A9, further comprising an adjuvant.

A11. The vaccine of aspect a10, wherein the adjuvant is an aluminium salt adjuvant, optionally in combination with AS01, AS03, MF59, imiquimod and/or CpG 1018.

A12. The vaccine of aspect a11, wherein the aluminum salt adjuvant is aluminum hydroxide or aluminum phosphate salt.

The vaccine of any one of a10-a12, wherein the vaccine comprises or further comprises an adjuvant comprising a peptide and a deoxynucleotide-containing immunostimulatory oligonucleotide molecule (I-ODN).

A14. The vaccine of aspect a13, wherein the peptide comprises the sequence klklklkll ₅ KLK (SEQ ID NO: 5) and the I-ODN comprises oligo-d (IC) ₁₃ (SEQ ID NO:6)。

A15. The vaccine of any one of aspects A1-a14, further comprising one or more pharmaceutically acceptable excipients.

B1. A kit comprising a SARS-CoV-2 vaccine of any of aspects A1-a 15.

B2. The kit of aspect B1, further comprising a second vaccine.

B3. The kit of aspect B2, wherein the second vaccine is another SARS-CoV-2 viral vaccine (e.g., another technology, such as mRNA or adenoviral vectors), an influenza viral vaccine, or a chikungunya viral vaccine.

C1. A method comprising administering to a subject in need thereof a therapeutically effective amount of a SARS-CoV-2 vaccine of any one of aspects A1-a 15.

C2. The method of aspect C1, further comprising administering a therapeutically effective amount of a second dose of a SARS-CoV-2 vaccine.

C3. The method of aspect C1 or C2, wherein the second dose of SARS-CoV-2 is administered about 7 days after the first dose of SARS-CoV-2 vaccine.

C4. The method of aspect C1 or C2, wherein the second dose of SARS-CoV-2 is administered about 14 days after the first dose of SARS-CoV-2 vaccine.

C5. The method of aspect C1 or C2, wherein the second dose of SARS-CoV-2 is administered about 21 days after the first dose of SARS-CoV-2 vaccine.

C6. The method of aspect C1 or C2, wherein the second dose of SARS-CoV-2 is administered about 28 days after the first dose of SARS-CoV-2 vaccine.

C7. The method of any one of aspects C1-C5, wherein the administering results in the production of SARS-CoV-2 neutralizing antibodies.

D1. A method of making a SARS-CoV-2 vaccine, comprising:

(i) Passaging SARS-CoV-2 on Vero cells to produce a culture medium comprising SARS-CoV-2;

(ii) (ii) harvesting the culture medium of (i);

(iii) (iii) precipitating the harvest medium of (ii), thereby producing a SARS-CoV-2 supernatant; and

(iv) (iv) optimally inactivating SARS-CoV-2in the supernatant of SARS-CoV-2 of (iii), thereby producing inactivated SARS-CoV-2.

D2. The method of aspect D1, further comprising concentrating the medium of (ii) prior to step (iii).

D3. The method of aspect D1 or D2, wherein the precipitating of (iii) comprises contacting the medium of (ii) with protamine sulfate or benzoate enzyme.

D4. The method of any of aspects D1-D3, further comprising (v) dialyzing the inactivated SARS-CoV-2 of (iv), thereby producing dialyzed SARS-CoV-2.

D5. The method of aspect D4, further comprising step (vi) comprising filtering the dialyzed SARS-CoV-2 of (v).

D6. The method of any one of aspects D1-D5, wherein the inactivation is by chemical inactivation, heat inactivation, pH inactivation, or UV inactivation.

D7. The method of aspect D6, wherein chemically inactivating comprises contacting the SARS-CoV-2 particle with a chemical inactivating agent for at least 4 days.

D8. The method of aspect D6 or D7, wherein the chemical inactivator comprises formaldehyde.

D9. The method of any one of aspects D6-D8, wherein the chemical activation is performed at about 4 ℃ or about 22 ℃.

D10. The method of aspect D8 or D9, further comprising neutralizing the formaldehyde.

D11. The method of aspect D10, wherein the neutralization is with sodium metabisulfite.

D12. The method of any one of aspects D1-D11, wherein the chemical inactivation is performed with BPL, preferably at a concentration of 300-700ppm, more preferably at a concentration of 500ppm, and inactivation is performed at 2 ℃ to 8 ℃ for about 1-48 hours, preferably 20-28 hours, most preferably 24 hours ± 2 hours (e.g., also ± 1 hour or ± 0.5 hours).

D13. The method of aspect D12, wherein the chemical inactivation is followed by a hydrolysis step performed at 35 ℃ to 39 ℃, preferably about 37 ℃, for 2.5 hours ± 0.5 hours.

E1. Use of the optimally inactivated SARS-CoV-2 vaccine of any one of aspects A1 to a15 for the treatment and/or prevention of SARS-CoV-2 infection.

E2. The use of aspect E1, wherein the inactivated SARS-CoV-2 vaccine is administered to a subject in need thereof at a first dose of a therapeutically effective amount.

E3. The use of aspect E2, wherein the inactivated SARS-CoV-2 vaccine is administered to the subject at a therapeutically effective amount of the second dose.

E4. The use of aspect E3, wherein the second dose of inactivated SARS-CoV-2 bacterin is administered about 7 days after the first dose of SARS-CoV-2 vaccine.

E5. The use of aspect E3, wherein the second dose of SARS-CoV-2 is administered about 14 days after the first dose of SARS-CoV-2 vaccine.

E6. The use of aspect E3, wherein the second dose of SARS-CoV-2 is administered about 21 days after the first dose of SARS-CoV-2 vaccine.

E7. The use of aspect E3, wherein the second dose of SARS-CoV-2 is administered about 28 days after the first dose of SARS-CoV-2 vaccine.

E8. The use of any of aspects E1-E6, wherein the administration results in the production of SARS-CoV-2 neutralizing antibodies.

F1. A pharmaceutical composition for the treatment and prevention of SARS-CoV-2infection, wherein the pharmaceutical composition comprises the optimally inactivated SARS-CoV-2 vaccine of any of aspects A1 to a15.

F2. The pharmaceutical composition of aspect F1, wherein the inactivated SARS-CoV-2 vaccine is administered to a subject in need thereof at a first dose of a therapeutically effective amount.

F3. The use of aspect F2, wherein the inactivated SARS-CoV-2 vaccine is administered to the subject at a therapeutically effective amount of the second dose.

F4. The use of aspect F3, wherein the second dose of inactivated SARS-CoV-2 vaccine is administered about 7 days after the first dose of SARS-CoV-2 vaccine.

F5. The use of aspect F3, wherein the second dose of SARS-CoV-2 is administered about 14 days after the first dose of SARS-CoV-2 vaccine.

F6. The use of aspect F3, wherein the second dose of SARS-CoV-2 is administered about 21 days after the first dose of SARS-CoV-2 vaccine.

F7. The use of aspect F3, wherein the second dose of SARS-CoV-2 is administered about 28 days after the first dose of SARS-CoV-2 vaccine.

F8. The use of any of aspects F1-F6, wherein the administration results in the production of SARS-CoV-2 neutralizing antibodies.

G1. A SARS-CoV-2 vaccine comprising an effective amount of antigen, wherein the effective amount is capable of seroconverting a subject administered with a SARS-CoV-2 vaccine with a probability of at least 70%.

G2. The SARS-CoV-2 vaccine of aspect G1, wherein the effective amount is capable of seroconverting a subject administered SARS-CoV-2 with a probability of at least 80%, 85%, 90%, or 95%.

G3. A SARS-CoV-2 vaccine according to aspect G1 or G2, wherein the effective amount is about 1 to 100 AU/dose, preferably about 2 to 75 AU/dose, preferably about 3 to 60 AU/dose, more preferably about 3 and 55 AU/dose, more preferably about 3 and 53 AU/dose.

G4. SARS-CoV-2 vaccine according to aspect G3, wherein the effective amount is determined by ELISA, wherein the Antigenic Units (AU) correspond to the ACE-2 binding capacity of the spike protein used as a standard.

H1. A SARS-CoV-2 vaccine comprising inactivated SARS-CoV-2 particles; wherein the native surface conformation of the SARS-CoV-2 particle is preserved in the vaccine such that the vaccine is capable of producing neutralizing antibodies against the native SARS-CoV-2 particle in a human subject.

H2. The SARS-CoV-2 vaccine according to aspect H1, wherein the viral RNA in the inactivated SARS-CoV-2 particle is replication deficient.

H3. SARS-CoV-2 vaccine according to aspect H1 or H2, wherein the viral RNA in the inactivated SARS-CoV-2 particles (i) is alkylated and/or acylated, (ii) comprises one or more modified purine (preferably guanine) residues or strand breaks, and/or (iii) is cross-linked with one or more viral proteins.

H4. A SARS-CoV-2 vaccine according to any of the preceding aspects, wherein the inactivated SARS-CoV-1 particles are beta-propiolactone inactivated SARS-CoV-2 particles, preferably at a concentration of 300-700ppm, more preferably 500ppm, and inactivated at 2 ℃ to 8 ℃ for about 1-48h, preferably 20-28h, most preferably 24 hours ± 2 hours (e.g. also ± 1 hour or ± 0.5 hour), followed by optionally hydrolysis at 35 ℃ to 39 ℃, preferably about 37 ℃ for 2.5 hours ± 0.5 hours.

H5. A SARS-CoV-2 vaccine according to any one of the preceding aspects, wherein the inactivated SARS-CoV-2 particles are Ultraviolet (UV) inactivated SARS-CoV-2 particles.

H6. A SARS-CoV-2 vaccine according to any of the preceding aspects, wherein the surface protein in inactivated SARS-CoV-2 comprises reduced modifications compared to viral RNA in inactivated SARS-CoV-2 particles, preferably wherein the surface protein comprises a reduced proportion of modified residues compared to viral RNA in inactivated SARS-CoV-2; the modification relates to native SARS-CoV-2 particles, preferably wherein the modification comprises alkylated and/or acylated nucleotide or amino acid residues.

H7. A SARS-CoV-2 vaccine according to any preceding aspect, wherein the inactivated SARS-CoV-1 particle comprises (i) a native conformation of the spike (S) protein; (ii) a nucleocapsid (N) protein; (iii) a membrane (M) glycoprotein; and/or (iv) envelope (E) proteins; preferably, wherein said inactivated SARS-CoV-2 particle comprises a native conformational spike (S) protein.

H8. A SARS-CoV-2 vaccine according to any of the preceding aspects, wherein the infectivity of mammalian cells by the inactivated SARS-CoV-2 particle is reduced by at least 99%, 99.99% or 99.9999% compared to native SARS-CoV-2 particle, or wherein the infectivity of mammalian cells of the inactivated SARS-CoV-2 particle is undetectable.

H9. The SARS-CoV-2 vaccine according to any of the preceding aspects, further comprising one or more pharmaceutically acceptable excipients, such as Human Serum Albumin (HSA).

H10. A SARS-CoV-2 vaccine according to any one of the preceding aspects, further comprising an adjuvant.

H11. The SARS-CoV-2 vaccine according to aspect H10, wherein the adjuvant comprises aluminum hydroxide or aluminum phosphate.

H12. The SARS-CoV-2 vaccine according to aspect H11, wherein the aluminium hydroxide or aluminium phosphate is the only adjuvant in the vaccine.

H13. A SARS-CoV-2 vaccine according to aspect H10 or 11, wherein the adjuvant comprises or further comprises a Th1 response-directing adjuvant.

H14. The SARS-CoV-2 vaccine according to aspect H13, wherein the Th1 response-directing adjuvant comprises 3-O-deacyl-4' -monophosphoryl lipid a (MPL), saponin QS-21, a CpG-containing oligonucleotide (CpG ODN), squalene, DL-alpha-tocopherol, a cationic peptide, a deoxynucleotide-containing immunostimulatory oligonucleotide molecule (I-ODN), and/or imiquimod.

H15. The SARS-CoV-2 vaccine according to aspect H10, wherein the adjuvant comprises:

(i) A liposomal formulation comprising 3-O-deacyl-4' -monophosphoryl lipid a (MPL) and saponin QS-21, preferably adjuvant system 01;

(ii) CpG ODN comprising sequence 5 'TGACTGTGAACGTTCGAGAGATGA 3' (SEQ ID NO: 4), preferably CpG 1018;

(iii) Squalene, DL-alpha-tocopherol and polysorbate 80 (preferably adjuvant system 03);

(iv) An oil-in-water emulsion comprising squalene, tween 80 and Span 85, preferably MF59;

(v) Sequence KLKLKLKLL ₅ KLK (SEQ ID NO: 5) and oligo-d (IC) ₁₃ (SEQ ID NO: 6), preferably IC 31; or

(vi) An aluminium salt and optionally a Th 1-directing adjuvant.

H16. A SARS-CoV-2 vaccine according to any preceding aspect, wherein the vaccine is capable of seroconverting a subject administered SARS-CoV-2 with at least 70% probability.

H17. The SARS-CoV-2 vaccine of aspect H16, wherein the SARS-CoV-2 vaccine is capable of serotransforming a subject administered with the SARS-CoV-2 vaccine with a probability of at least 80%, 85%, 90%, or 95%.

H18. A SARS-CoV-2 vaccine according to any preceding aspect, wherein the SARS-CoV-2 particles comprise an RNA sequence (and/or a fragment thereof, optionally comprising modified (preferably alkylated or acylated) nucleotide residues) corresponding to the DNA sequence (i) as defined by SEQ ID NO:9; or (ii) has at least 80%, at least 85%, at least 90%, at least 95%, or at least 99% sequence identity to SEQ ID NO. 9; preferably, the native (non-inactivated) SARS-CoV-2 particle comprising the RNA sequence therein is capable of encapsulating virulent SARS-CoV-2.

H19. A SARS-CoV-2 vaccine according to any preceding aspect, wherein the vaccine comprises additional SARS-CoV-2 particles, which particles comprise an RNA sequence (and/or a fragment thereof, optionally comprising modified (preferably alkylated or acylated) nucleotide residues) corresponding to the DNA sequence (i) as defined by SEQ ID NO:18; or (ii) has at least 80%, at least 85%, at least 90%, at least 95%, or at least 99% sequence identity to SEQ ID NO 18; preferably, the native (non-inactivated) SARS-CoV-2 particle comprising the RNA sequence therein is capable of encapsulating virulent SARS-CoV-2.

H20. A SARS-CoV-2 vaccine according to any preceding aspect, wherein the vaccine comprises additional SARS-CoV-2 particles, which particles comprise an RNA sequence (and/or a fragment thereof, optionally comprising modified (preferably alkylated or acylated) nucleotide residues) corresponding to the DNA sequence (i) as defined by SEQ ID NO:22; or (ii) has at least 80%, at least 85%, at least 90%, at least 95%, or at least 99% sequence identity to SEQ ID NO 22; preferably, the native (non-inactivated) SARS-CoV-2 particle comprising the RNA sequence therein is capable of encapsulating virulent SARS-CoV-2.

H21. A SARS-CoV-2 vaccine according to any of the preceding aspects, wherein the vaccine is obtained or obtainable from Vero cells.

H22. A SARS-CoV-2 vaccine according to any preceding aspect, wherein, upon administration to a human subject, the vaccine (i) does not induce Antibody Dependent Enhancement (ADE) of SARS-CoV-2 related disease (COVID-19); and/or (ii) does not induce immunopathology in the subject.

H23. A method of preventing or treating SARS-CoV-2infection and/or SARS-CoV-2 related disease (COVID-19) in a human subject in need thereof, comprising vaccinating the subject with a prophylactically or therapeutically effective amount of a SARS-CoV-2 vaccine of any of the preceding aspects.

H24. The method of aspect H23, further comprising administering a prophylactically or therapeutically effective amount of a second dose of SARS-CoV-2 vaccine, preferably wherein the second dose of vaccine is the same formulation as the first dose.

H25. The method according to aspect H23 or H24, wherein the prophylactically or therapeutically effective amount of SARS-CoV-2 vaccine is defined per dose as about 1 to 100 AU/dose, preferably about 2 to 75 AU/dose, preferably about 3 to 60 AU/dose, more preferably about 3 and 55 AU/dose, more preferably about 3 to 53 AU/dose, even more preferably between about 3 to 40 AU/dose, e.g. 40 AU/dose.

H26. The method of aspect H23 or 24, wherein the prophylactically or therapeutically effective amount of SARS-CoV-2 vaccine per dose is defined as about 0.05 to 50 μ g total protein, about 0.1 to 25 μ g, about 0.25 to 12.5 μ g, preferably about 0.5 to 5 μ g total protein, as measured by (μ) BCA.

H27. The method according to aspect H23 or H24, wherein the prophylactically or therapeutically effective amount of SARS-CoV-2 vaccine per dose is defined as about 0.025 to 25 μ g S protein, about 0.05 to 12.5 μ g, about 0.125 to 6.25 μ g, preferably about 0.25 to 2.5 μ g S protein, as measured by ELISA.

H28. The method of aspect H24, wherein the second dose of SARS-CoV-2 vaccine is administered about 7 days, about 14 days, about 21 days, or about 28 days after the first dose of SARS-CoV-2 vaccination, preferably wherein the second dose of vaccine is the same formulation as the first dose.

H29. The method of any one of aspects H22-H28, wherein the administering results in the production of SARS-CoV-2 neutralizing antibodies.

H30. A method of making a SARS-CoV-2 vaccine, comprising:

(a) Preparing natural SARS-CoV-2 particle;

(b) Inactivating said native SARS-CoV-2 particles to obtain inactivated SARS-CoV-2 particles;

(c) Incorporating inactivated SARS-CoV-2 particles into a vaccine composition;

wherein the native surface conformation of the SARS-CoV-2 particle is retained during the inactivation step such that the vaccine is capable of producing neutralizing antibodies against the native SARS-CoV-2 particle in a human subject.

H31. The method according to aspect H30, wherein the vaccine composition comprises aluminum hydroxide.

H32. The method according to aspect H31, wherein the SARS-CoV-2 vaccine comprising aluminum hydroxide contains less than 1.25ppb copper.

H33. The method of aspect H32, wherein the inactivating step preferentially targets viral RNA in SARS-CoV-2 particles.

H34. The method according to aspect H30 or H33, wherein the inactivation step comprises (i) alkylating and/or acylating the viral RNA (ii) modifying purine (preferably guanine) residues or introducing strand breaks into the viral RNA and/or (iii) cross-linking the viral RNA with one or more viral proteins.

H35. The method according to any one of aspects H30, H33 or H34, wherein the inactivating step comprises treating native SARS-CoV-2 particles with beta-propiolactone.

H36. The method according to aspect H35, wherein the concentration of β -propiolactone in the inactivation step is from 0.01 to 1 wt.%, preferably from 0.05 to 0.5 wt.%, more preferably about 0.1 wt.%.

H37. The method of aspect H35 or H36, wherein the native SARS-CoV-2 particles are contacted with beta-propiolactone for at least 5 hours, at least 10 hours, at least 24 hours, or at least 4 days.

H38. The method of any one of aspects H30 or H33-H37, wherein the inactivation step is performed at about 0 ℃ to about 25 ℃, preferably about 4 ℃ or about 22 ℃.

H39. The method of any of aspects H30 or H33-H38, wherein the inactivating step comprises treating the native SARS-CoV-2 particles with Ultraviolet (UV) light.

H40. The method according to any one of aspects H30 or H33 to H39, wherein step (a) comprises one or more of the following steps:

(i) Passaging SARS-CoV-2 on Vero cells to produce a medium comprising SARS-CoV-2;

(ii) (ii) harvesting the culture medium of (i);

(iii) (iii) precipitating the harvest medium of (ii) thereby producing native SARS-CoV-2 particles in the supernatant.

H41. The method according to aspect H40, further comprising concentrating the medium of (ii) prior to step (iii).

H42. The method according to aspect H40 or H41, wherein the precipitating of (iii) comprises contacting the medium of (ii) with protamine sulfate or benzoate enzyme.

H43. The method according to any of aspects H30 or H33 to H42, further comprising dialyzing the inactivated SARS-CoV-2 particles, thereby producing dialyzed SARS-CoV-2.

H44. The method according to aspect H43, further comprising filtering the dialyzed SARS-CoV-2.

H45. The method of any of aspects H30 or H33-H44, wherein the inactivating step comprises contacting the liquid composition comprising native SARS-CoV-2 particles with a chemical virucidal agent in a container, mixing the chemical virucidal agent and the liquid composition comprising SARS-CoV-2 particles under conditions of laminar flow rather than turbulent flow, and incubating the chemical virucidal agent and the liquid composition comprising SARS-CoV-2 particles for a time sufficient to inactivate the viral particles.

H46. The method according to aspect H45, wherein the inactivating step is performed in a flexible bioreactor bag.

H47. The method according to aspect H45 or H46, wherein the inactivating step comprises five or fewer container inversions during inactivation.

H48. The method of any of aspects H45-H47, wherein mixing of the chemical virus-inactivating agent and the composition comprising native SARS-CoV-2 particles comprises rocking, rotating, orbital shaking, or oscillating the container at no more than 10rpm for no more than 10 minutes during incubation.

H49. The method according to any one of aspects H30 or H33 to H48, further comprising purifying the inactivated SARS-CoV-2 particles by one or more methods selected from (i) batch chromatography and/or (ii) sucrose density gradient centrifugation.

H50. The method according to any of aspects H30 or H33 to H49, wherein step (c) comprises combining inactivated SARS-CoV-2 particles with an adjuvant.

H51. The method according to aspect H50, wherein the adjuvant comprises a Th1 response-directing adjuvant.

H52. The method of aspect H50 or H51, wherein the adjuvant comprises 3-O-deacyl-4' -monophosphoryl lipid a (MPL), saponin QS-21, a CpG-containing oligonucleotide (CpG ODN), squalene, DL-alpha-tocopherol and/or imiquimod.

H53. A SARS-CoV-2 vaccine obtained or obtainable by the method of any of aspects H30 or H33 to H52.

Use of a SARS-CoV-2 vaccine of any one of aspects H1 to H22 or H53 for treating or preventing infection in SARS-CoV-2in a subject.

H55. A pharmaceutical composition for use in the prevention or treatment of a SARS-CoV-2infection in a subject, wherein the pharmaceutical composition is an inactivated SARS-CoV-2 vaccine as defined in any of the aspects H1 to H22 or H53, optionally in combination with one or more pharmaceutically acceptable excipients and/or adjuvants.

H56. A SARS-CoV-2 vaccine as defined in any of aspects H1 to H22 or H53 for use as a medicament.

H57. The vaccine, method, use or pharmaceutical composition according to any preceding aspect, wherein the subject is (i) an elderly subject, preferably a subject over 65 years old, over 70 years old or over 80 years old; (ii) an immunocompromised subject; or (iii) a pregnant subject.

H58. A vaccine, method, use or pharmaceutical composition according to any preceding aspect, for preventing or treating a SARS-CoV-2infection without inducing (i) Antibody Dependent Enhancement (ADE) of a SARS-CoV-2 related disease (new coronary pneumonia); and/or (ii) immunopathology of the subject.

The present application claims priority from EP20168324.0 (6/4/2020), EP 20202118.4 (15/10/2020), EP 2020 11853.5 (4/12/2020), EP21154647.8 (1/2/2021), PCT/US2021/20313 (1/3/1/2021) and EP 21160913.6 (5/3/2021), the contents of which are incorporated herein by reference. All publications mentioned in the above specification are herein incorporated by reference. Various modifications and alterations to the described embodiments of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. While the invention has been described in connection with certain preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the described modes for carrying out the invention which are obvious to those skilled in the art are intended to be within the scope of the following claims.

Sequence listing

SEQ ID NO:1

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a whole genome virus isolated from Wuhan-Hu-1 (GenBank: MN908947; wu, F., et al. A new coronavir associated with human respiratory disease in China (2020) Nature579: 265-269)

ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATC

TCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTC

ACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAAT

TACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCT

GCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTT

TCGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGT

TTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGT

TCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCT

TATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTA

GAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTT

CATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGT

TGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTG

AGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCT

TACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGG

CCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGC

TTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAA

CATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGG

GGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTA

CCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTT

CATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGT

GTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGA

ACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAAT

TGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTAT

TTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGA

AAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTG

CGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAG

TGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAA

AGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTG

CCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTG

TCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCG

AATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTC

GCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATA

ACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTA

ACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAAC

CTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGG

TGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCT

GCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAA

AGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAA

AGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCA

ATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTA

CGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGT

GTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTAT

TCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTA

ACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGA

CTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCA

AACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGA

GTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGC

TTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTA

AGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTT

TGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGA

ATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAG

TGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGC

CCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAG

TGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTA

GAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACC

AGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAA

AGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCA

CACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACT

GTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACT

TGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATAC

AGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAG

ATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCAC

TGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGA

TGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTCTAC

CCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGT

TTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAG

GTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAA

GAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTG

TTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCA

AACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAG

TTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTA

CTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAA

AAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAA

ACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATG

CCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTA

AAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACAC

TGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCA

ACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACT

TGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCT

TTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTC

TTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATG

AAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAG

AGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAG

AGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTA

CAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTT

TATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTA

GTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGG

GTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTA

AAAAGGCTGGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAA

AGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAA

TGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAA

AGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAA

TTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCA

GAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCAT

AGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGG

TGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAAC

TGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGT

TACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGC

TGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTC

TTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCT

AAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTC

CTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGA

ATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTAC

CACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGAC

ACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAG

TAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACA

TATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACT

AAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTA

CCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACA

ACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACT

AAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGG

GCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAA

ATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGA

GCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTAC

TGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAG

TTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAA

CGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGT

GTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAG

AAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATA

TCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGC

TCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACAC

TGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAAC

TTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAA

AGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAA

CCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAA

TTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCA

CAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCA

AGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATG

ATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTT

AAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATT

ATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATA

AACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATA

AACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTT

GAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGG

AATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAG

TAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTG

AAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAA

TAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTG

CTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATC

TAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGT

TAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTT

AACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAA

CCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAAT

TGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGC

CGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTC

TAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGAT

AAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAA

TCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCC

TTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGT

CACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTT

AGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAA

TTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGC

AGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTT

GGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATT

TTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATG

GCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTT

ATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATC

AACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAAT

GTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAA

TGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATT

GTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGA

GAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAG

TCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCAT

CTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTC

TCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGT

TCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAG

AATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTC

AACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATA

GTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTT

CATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCA

ACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTT

ATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGT

AGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGA

CATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAAC

AAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTG

TAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTG

CTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTAC

GAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAG

TTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAA

GATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTT

AATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAA

TAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAA

TCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCAT

CTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGT

TTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGA

TTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTG

CCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTA

CCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAA

CTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCT

GAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTT

ATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCC

CTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAA

CACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGA

GTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTG

TATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTT

ACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTACTAATAT

GTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCT

ATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTTGCCTACT

ATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTG

CCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACA

CCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTT

GACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGA

TGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATAT

CATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTA

AAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAA

GCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTG

CGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTC

TTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCT

ACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTC

AGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATC

ACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCT

GGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTAC

ACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGT

GATCTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACT

CATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAA

CTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAG

GTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATT

CAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACC

ATCTGGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTATTAAGGG

TTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTAT

GACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGA

GTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTT

GACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAG

TTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGT

GGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGG

CTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATAC

TAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTG

CTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATAT

TGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAG

ACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCA

AGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAG

TTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAA

TGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAA

TGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACC

TTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTT

GGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTC

TGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTT

ACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAG

AGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTAT

GGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTG

TTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCA

GAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAAC

TGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTAT

TTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTA

GACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTA

GATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATG

CCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTA

TCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACA

TCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCA

TCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTA

GCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCT

GTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGA

AGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGT

TTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTA

TGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGT

TGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCA

GCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCA

AATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTA

GTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATG

ATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCT

TGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATAC

CAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTA

TGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTA

AAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAG

CATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAAT

TACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTG

CTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTT

ACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCC

GATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACT

GGTACTATCTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGAC

ACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTA

AACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGT

ACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTG

TATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGA

TTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTT

GTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAG

CCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACT

GCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAA

AAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGG

GTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAA

GGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCA

GCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCC

CGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAG

GGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCT

AAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATT

TAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACC

AACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTG

CTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCAC

ATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCT

ATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAA

TACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGG

ACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCA

ACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTC

TGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGAT

AATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAA

ACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTG

TTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACAT

GTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAA

TATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAA

TATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGAC

AGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGT

TCCCACCTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATG

GTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTG

TTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAA

GGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGG

TAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTT

ACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAA

GACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGT

TCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCT

ATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATA

TCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATT

GTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACC

TAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGAC

TTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATA

TACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTAT

GCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTAT

CTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATC

AATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAAT

TCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAG

AAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCA

TGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAAC

ATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATG

AGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTAT

ATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTAT

GCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAAT

GCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGC

AATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTT

GACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTC

TCAATGATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCACTT

ATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTC

TTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTG

AGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAA

TGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATC

CATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAA

CAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATG

CTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCA

TTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACA

CATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGG

TATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTC

TTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTA

AGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTT

ACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCC

GTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACT

TTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATT

AGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATA

CATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACAT

GTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTG

AAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGA

GACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTC

TGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCAC

CACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACA

GTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGT

GATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGT

GATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTA

CACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAA

CACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAA

AGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACT

GGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTC

GCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTG

AGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACC

TGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAA

CATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGA

CAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATG

ATTTGAGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTGTACA

TTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAG

GGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAA

AACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTG

CTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTA

AAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGG

GTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAG

GCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCT

GTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTT

TGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATAT

GACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAAT

GTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTT

TGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGT

CTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGT

AACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCC

TACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTG

AAGGTTTATGTGTTGACATACCTGGCATACCTAAGGACATGACCTATA

GAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATG

GTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTAC

GTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAA

GCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTT

AACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACA

GATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAA

CACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGT

ATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGAC

AGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATG

AAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGAT

AGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGG

CATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGT

TCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGT

ATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCA

TGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGAC

TGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCG

GCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCA

GACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAG

TGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCT

TGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCA

CACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCA

ATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAG

AGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTA

TGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTT

TGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGT

GAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTA

AAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGT

AGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGA

TGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTT

ATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTG

GCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGA

AGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGG

TGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGT

AGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGG

TGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGA

TCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTG

TTTGTTCTATGACTGACATAGCCAAGAAACCAACTGAAACGATTTGT

GCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGA

CTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAAGGTAGTGTT

AAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGG

AGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAA

GAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCA

GAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTG

ATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGA

AGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAG

TTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAA

TCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAA

AACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGT

TCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCA

AGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATAC

AGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATT

TTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTAT

GCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACC

TTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGA

ATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATT

AGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGAT

AAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTAC

GGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGC

AGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAA

ATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTT

ACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGG

GTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGAT

AACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTT

CGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGA

AGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAAT

AGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAA

TCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCC

CTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATC

AATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAG

AAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAA

CGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGT

GTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACACTAATT

CTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAG

TTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTAC

TTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTT

TGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACT

GAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGAT

TCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTA

TTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTGTTTA

TTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTT

TATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTC

TTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAA

TTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACA

CGCCTATTAATTTAGTGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAG

AACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAA

CTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTC

AGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACC

TAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGC

TGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGA

AATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAG

TCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTG

CCCTTTTGGTGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGC

TTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCC

TATATAATTCCGCATCATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCT

ACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTG

TAATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGGGCAAACTGG

AAAGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGC

GTTATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAATT

ATAATTACCTGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGA

GAGAGATATTTCAACTGAAATCTATCAGGCCGGTAGCACACCTTGTAA

TGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACAATCATATGGTTTC

CAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTAGTAGTACTT

TCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAA

GTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGG

TTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGC

CTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCC

GTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTG

GTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTT

GCTGTTCTTTATCAGGATGTTAACTGCACAGAAGTCCCTGTTGCTATT

CATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTA

ATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAACATGTC

AACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCT

AGTTATCAGACTCAGACTAATTCTCCTCGGCGGGCACGTAGTGTAGCT

AGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCA

GTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTA

GTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTA

GATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTT

TTGTTGCAATATGGCAGTTTTTGTACACAATTAAACCGTGCTTTAACT

GGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCAC

AAGTCAAACAAATTTACAAAACACCACCAATTAAAGATTTTGGTGGT

TTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGG

TCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCT

GGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGA

GACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCT

TTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCG

GGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACA

AATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTT

ACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTT

AATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAG

TGCACTTGGAAAACTTCAAGATGTGGTCAACCAAAATGCACAAGCTT

TAAACACGCTTGTTAAACAACTTAGCTCCAATTTTGGTGCAATTTCAA

GTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAG

TGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACA

TATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCT

AATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAA

AAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCA

GTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGC

ACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAA

AAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACAC

TGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACA

GACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTC

AACAACACAGTTTATGATCCTTTGCAACCTGAATTAGACTCATTCAAG

GAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGAT

TTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAA

GAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCT

CATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCC

ATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATG

GTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAG

GGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCT

GAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTT

ATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAG

CAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACT

GCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTT

GGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACC

CTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGT

TTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCT

CGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTC

TACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGG

CTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAAC

TATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAA

TAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAG

TCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATG

GGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTC

AGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTG

TTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTG

AAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTT

AATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAG

CGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATT

CGTTTCGGAAGAGACAGGTACGTTAATAGTTAATAGCGTACTTCTTTT

TCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCG

CTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTA

AAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTA

GAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTT

CTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATT

ACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAAT

AGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCC

AACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGT

TATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAAT

AAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGG

CTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCG

TACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAA

CGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTG

AACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTG

GACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATC

ACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCG

CAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAG

GATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACA

ATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTT

GACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGAGGACTT

TTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAA

AAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGA

AGAGCAACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTT

CTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGA

GTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTG

GAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAAT

TTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACG

GCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAA

CTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTT

TCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAA

AAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGC

TTTTTAGCCTTTCTGCTATTCCTTGTTTTAATTATGCTTATTATCTTTTG

GTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAA

CGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTG

CATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCAT

ATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATT

AGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGA

TGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTAT

ACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTG

GGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTAT

CATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTAAAA

TGTCTGATAATGGACCCCAAAATCAGCGAAATGCACCCCGCATTACG

TTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACG

CAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAAT

AATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGA

CCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCA

GTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATT

CGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTT

CTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTA

ACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACA

CCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAAT

CGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACG

CAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATC

ACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAGG

GGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCT

TGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGT

CTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATC

TGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTA

AAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACA

AACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACT

GATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTC

AGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGG

GAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGAT

CCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCA

TACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGA

AGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCA

AACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACA

ATTGCAACAATCCATGAGCAGTGCTGACTCAACTCAGGCCTAAACTC

ATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTC

CGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTA

CATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTT

AATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTT

CACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCT

AGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTT

AGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACA

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

SEQ ID NO:2

Severe acute respiratory syndrome coronavirus 2orf1ab polyprotein of isolate Wuhan-Hu-1 (accession: QHD 43415)

MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKD

GTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQY

GRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDL

GDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCG

PDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWY

TERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKK

LDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKA

TCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYH

NESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHT

GVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAF

VETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAF

ASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMF

TSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEK

FKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNK

FLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPL

KAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVC

INGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIE

VQGYKSVNITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIK

TLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDED

EEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDW

LDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSF

SGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGAL

NKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNV

NKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRT

NVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPS

VEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLV

SDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLAKALRKV

PTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGT

VSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDY

GARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYM

RSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYS

GQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRT

IKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEG

KTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVN

GLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFC

ALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQ

QTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFV

MMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALL

TKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKK

DNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPA

SRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATN

KATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPV

SEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLM

AAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPF

LNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASM

PTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYS

TAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGL

DSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAI

MQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWK

SYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGK

GFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIV

DSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPIN

VIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAV

KMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAA

RQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMT

PRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAA

KKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLF

VAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHA

DFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDF

LHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPY

CYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSE

YCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLLTN

MFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAF

NTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMV

MFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALC

TFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREA

ACCHLAKALNDFSNSGSDVLYQPPQTSITSAVLQSGFRKMAFPSGKVEG

CMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSN

HNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQT

FSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC

YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAW

LYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQ

TGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTF

QSAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGII

AMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMT

WLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTL

MNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIV

FMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLG

VYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATV

QSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTE

AFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYA

AFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLE

KMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNN

IINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWE

IQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPV

ALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWA

RFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVL

GSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPIT

NCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPK

GFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLR

EPMLQSADAQSFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVA

GFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKD

CPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCD

TLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLK

TVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVD

SYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDR

YFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIF

VDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMH

AASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFK

EGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDK

YFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQD

ALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQK

LLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPK

CDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVM

CGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIAD

KYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVC

FNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCS

QHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSL

AIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTND

NTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLC

CKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKS

HKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILA

NTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKP

RPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLN

VGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQ

KVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALC

EKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTA

DIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPAPRTLLTKGTL

EPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHK

DKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISP

YNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNV

AITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCS

KVITGLHPTQAPTHLSVDTKFKTEGLCVDIPGIPKDMTYRRLISMMGFK

MNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQL

GFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLP

WNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERT

CCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQ

SNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDEL

KINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKF

YDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVC

RFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYS

DSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDA

YNMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDG

QQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPV

PEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETIC

APLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNG

VTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDF

LELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPF

ELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSV

VSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLY

KMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVP

YNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADST

LIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQ

KLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLI

GCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLR

GTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN

SEQ ID NO:3

<xnotran> 2 (GenBank: QHD 43416) MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT </xnotran>

SEQ ID NO:4

CpG 1018

TGACTGTGAACGTTCGAGATGA

SEQ ID NO:5

KLK peptides

KLKLLLLLKLK

SEQ ID NO:6

Oligo-d (IC) ₁₃ (ODN1a)

ICICICICICICICICICICICICIC

SEQ ID NO:7

CpG 1826

TCCATGACGTTCCTGACGTT

SEQ ID NO:8

CpG 7909

TCGTCGTTTTGTCGTTTTGTCGTT

SEQ ID NO:9

(> hCoV-19/Italy/INMI 1-isl/2020 non-ventilating EPI_ISL 410545 2020-01-29 (accession No: MT 066156)

ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATC

TCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTC

ACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAAT

TACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCT

GCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTT

TCGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGT

TTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGT

TCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCT

TATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTA

GAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTT

CATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGT

TGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTG

AGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCT

TACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGG

CCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGC

TTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAA

CATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGG

GGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTA

CCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTT

CATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGT

GTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGA

ACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAAT

TGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTAT

TTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGA

AAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTG

CGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAG

TGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAA

AGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTG

CCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTG

TCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCG

AATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTC

GCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATA

ACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTA

ACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAAC

CTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGG

TGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCT

GCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAA

AGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAA

AGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCA

ATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTA

CGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGT

GTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTAT

TCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTA

ACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGA

CTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCA

AACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGA

GTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGC

TTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCTAAGGAAATTA

AGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTT

TGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGA

ATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAG

TGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGC

CCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAG

TGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTA

GAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACC

AGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAA

AGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCA

CACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACT

GTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACT

TGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATAC

AGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAG

ATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCAC

TGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGA

TGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTCTAC

CCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGT

TTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAG

GTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAA

GAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTG

TTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCA

AACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAG

TTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTA

CTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAA

AAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAA

ACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATG

CCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTA

AAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACAC

TGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCA

ACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACT

TGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCT

TTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTC

TTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATG

AAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAG

AGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAG

AGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTA

CAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTT

TATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTA

GTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGG

GTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTA

AAAAGGCTGGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAA

AGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAA

TGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAA

AGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAA

TTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCA

GAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCAT

AGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGG

TGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAAC

TGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGT

TACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGC

TGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTC

TTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCT

AAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTC

CTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGA

ATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTAC

CACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGAC

ACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAG

TAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACA

TATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACT

AAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTA

CCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACA

ACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACT

AAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGG

GCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAA

ATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGA

GCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTAC

TGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAG

TTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAA

CGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGT

GTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAG

AAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATA

TCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGC

TCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACAC

TGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAAC

TTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAA

AGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAA

CCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAA

TTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCA

CAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCA

AGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATG

ATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTT

AAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATT

ATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATA

AACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATA

AACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTT

GAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGG

AATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAG

TAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTG

AAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAA

TAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTG

CTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATC

TAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGT

TAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTT

AACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAA

CCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAAT

TGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGC

CGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTC

TAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGAT

AAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAA

TCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCC

TTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGT

CACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTT

AGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAA

TTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGC

AGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTT

GGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATT

TTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATG

GCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTT

ATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATC

AACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAAT

GTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAA

TGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATT

GTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGA

GAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAG

TCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCAT

CTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTC

TCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGT

TCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAG

AATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTC

AACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATA

GTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTT

CATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCA

ACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTT

ATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGT

AGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGA

CATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAAC

AAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTG

TAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTG

CTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTAC

GAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAG

TTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAA

GATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTT

AATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAA

TAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAA

TCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCAT

CTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGT

TTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGA

TTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTG

CCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTA

CCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAA

CTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCT

GAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTT

ATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCC

CTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAA

CACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGA

GTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTG

TATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTT

ACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTACTAATAT

GTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCT

ATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTTGCCTACT

ATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTG

CCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACA

CCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTT

GACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGA

TGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATAT

CATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTA

AAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAA

GCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTG

CGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTC

TTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCT

ACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTC

AGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATC

ACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCT

GGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTAC

ACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGT

GATCTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACT

CATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAA

CTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAG

GTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATT

CAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACC

ATCTGGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTATTAAGGG

TTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTAT

GACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGA

GTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTT

GACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAG

TTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGT

GGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGG

CTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATAC

TAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTG

CTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATAT

TGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAG

ACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCA

AGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAG

TTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTNTATGAAAA

TGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAA

TGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACC

TTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTT

GGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTC

TGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTT

ACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAG

AGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTAT

GGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTG

TTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCA

GAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAAC

TGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTAT

TTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTA

GACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTA

GATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATG

CCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTA

TCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACA

TCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCA

TCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTA

GCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCT

GTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGA

AGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGT

TTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTA

TGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGT

TGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCA

GCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCA

AATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTA

GTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATG

ATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCT

TGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATAC

CAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTA

TGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTA

AAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAG

CATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAAT

TACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTG

CTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTT

ACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCC

GATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACT

GGTACTATCTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGAC

ACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTA

AACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGT

ACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTG

TATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGA

TTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTT

GTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAG

CCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACT

GCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAA

AAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGG

GTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAA

GGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCA

GCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCC

CGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAG

GGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCT

AAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATT

TAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACC

AACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTG

CTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCAC

ATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCT

ATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAA

TACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGG

ACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCA

ACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTC

TGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGAT

AATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAA

ACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTG

TTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACAT

GTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAA

TATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAA

TATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGAC

AGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGT

TCCCACCTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATG

GTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTG

TTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAA

GGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGG

TAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTT

ACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAA

GACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGT

TCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCT

ATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATA

TCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATT

GTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACC

TAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGAC

TTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATA

TACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTAT

GCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTAT

CTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATC

AATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAAT

TCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAG

AAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCA

TGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAAC

ATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATG

AGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTAT

ATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTAT

GCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAAT

GCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGC

AATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTT

GACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTC

TCAATGATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCACTT

ATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTC

TTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTG

AGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAA

TGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATC

CATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAA

CAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATG

CTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCA

TTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACA

CATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGG

TATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTC

TTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTA

AGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTT

ACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCC

GTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACT

TTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATT

AGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATA

CATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACAT

GTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTG

AAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGA

GACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTC

TGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCAC

CACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACA

GTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGT

GATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGT

GATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTA

CACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAA

CACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAA

AGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACT

GGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTC

GCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTG

AGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACC

TGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAA

CATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGA

CAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATG

ATTTGAGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTGTACA

TTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAG

GGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAA

AACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTG

CTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTA

AAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGG

GTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAG

GCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCT

GTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTT

TGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATAT

GACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAAT

GTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTT

TGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGT

CTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGT

AACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCC

TACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTG

AAGGTTTATGTGTTGACATACCTGGCATACCTAAGGACATGACCTATA

GAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATG

GTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTAC

GTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAA

GCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTT

AACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACA

GATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAA

CACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGT

ATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGAC

AGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATG

AAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGAT

AGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGG

CATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGT

TCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGT

ATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCA

TGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGAC

TGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCG

GCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCA

GACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAG

TGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCT

TGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCA

CACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCA

ATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAG

AGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTA

TGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTT

TGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGT

GAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTA

AAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGT

AGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGA

TGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTT

ATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTG

GCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGA

AGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGG

TGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGT

AGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGG

TGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGA

TCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTG

TTTGTTCTATGACTGACATAGCCAAGAAACCAACTGAAACGATTTGT

GCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGA

CTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAAGGTAGTGTT

AAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGG

AGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAA

GAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCA

GAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTG

ATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGA

AGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAG

TTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAA

TCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAA

AACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGT

TCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCA

AGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATAC

AGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATT

TTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTAT

GCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACC

TTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGA

ATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATT

AGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGAT

AAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTAC

GGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGC

AGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAA

ATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTT

ACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGG

GTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGAT

AACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTT

CGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGA

AGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAAT

AGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAA

TCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCC

CTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATC

AATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAG

AAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAA

CGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGT

GTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACACTAATT

CTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAG

TTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTAC

TTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTT

TGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACT

GAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGAT

TCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTA

TTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTGTTTA

TTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTT

TATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTC

TTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAA

TTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACA

CGCCTATTAATTTAGTGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAG

AACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAA

CTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTC

AGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACC

TAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGC

TGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGA

AATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAG

TCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTG

CCCTTTTGGTGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGC

TTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCC

TATATAATTCCGCATCATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCT

ACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTG

TAATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGGGCAAACTGG

AAAGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGC

GTTATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAATT

ATAATTACCTGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGA

GAGAGATATTTCAACTGAAATCTATCAGGCCGGTAGCACACCTTGTAA

TGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACAATCATATGGTTTC

CAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTAGTAGTACTT

TCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAA

GTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGG

TTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGC

CTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCC

GTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTG

GTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTT

GCTGTTCTTTATCAGGATGTTAACTGCACAGAAGTCCCTGTTGCTATT

CATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTA

ATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAACATGTC

AACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCT

AGTTATCAGACTCAGACTAATTCTCCTCGGCGGGCACGTAGTGTAGCT

AGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCA

GTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTA

GTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTA

GATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTT

TTGTTGCAATATGGCAGTTTTTGTACACAATTAAACCGTGCTTTAACT

GGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCAC

AAGTCAAACAAATTTACAAAACACCACCAATTAAAGATTTTGGTGGT

TTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGG

TCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCT

GGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGA

GACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCT

TTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCG

GGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACA

AATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTT

ACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTT

AATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAG

TGCACTTGGAAAACTTCAAGATGTGGTCAACCAAAATGCACAAGCTT

TAAACACGCTTGTTAAACAACTTAGCTCCAATTTTGGTGCAATTTCAA

GTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAG

TGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACA

TATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCT

AATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAA

AAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCA

GTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGC

ACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAA

AAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACAC

TGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACA

GACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTC

AACAACACAGTTTATGATCCTTTGCAACCTGAATTAGACTCATTCAAG

GAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGAT

TTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAA

GAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCT

CATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCC

ATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATG

GTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAG

GGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCT

GAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTT

ATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAG

CAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACT

GCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTT

GGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACC

CTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGT

TTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCT

CGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTC

TACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGG

CTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAAC

TATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAA

TAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAG

TCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATG

GGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTC

AGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTG

TTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTG

AAGAACATGTCCAAATTCACACAATCGACGTTTCATCCGGAGTTGTT

AATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAG

CGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATT

CGTTTCGGAAGAGACAGGTACGTTAATAGTTAATAGCGTACTTCTTTT

TCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCG

CTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTA

AAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTA

GAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTT

CTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATT

ACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAAT

AGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCC

AACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGT

TATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAAT

AAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGG

CTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCG

TACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAA

CGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTG

AACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTG

GACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATC

ACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCG

CAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAG

GATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACA

ATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTT

GACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGAGGACTT

TTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAA

AAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGA

AGAGCAACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTT

CTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGA

GTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTG

GAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAAT

TTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACG

GCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAA

CTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTT

TCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAA

AAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGC

TTTTTAGCCTTTCTGCTATTCCTTGTTTTAATTATGCTTATTATCTTTTG

GTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAA

CGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTG

CATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCAT

ATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATT

AGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGA

TGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTAT

ACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTG

GGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTAT

CATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTAAAA

TGTCTGATAATGGACCCCAAAATCAGCGAAATGCACCCCGCATTACG

TTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACG

CAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAAT

AATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGA

CCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCA

GTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATT

CGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTT

CTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTA

ACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACA

CCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAAT

CGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACG

CAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATC

ACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAGG

GGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCT

TGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGT

CTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATC

TGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTA

AAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACA

AACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACT

GATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTC

AGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGG

GAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGAT

CCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCA

TACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGA

AGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCA

AACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACA

ATTGCAACAATCCATGAGCAGTGCTGACTCAACTCAGGCCTAAACTC

ATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTC

CGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTA

CATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTT

AATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTT

CACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCT

AGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTT

AGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAAT

SEQ ID NO:10

Severe acute respiratory syndrome coronavirus 2orf1ab polyprotein of isolate hCoV-19/Italy/INMI 1-isl/2020 (Genbank Acc.No: QIA 98553)

MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKD

GTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQY

GRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDL

GDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCG

PDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWY

TERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKK

LDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKA

TCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYH

NESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHT

GVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAF

VETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAF

ASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMF

TSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEK

FKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNK

FLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPL

KAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVC

INGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIE

VQGYKSVNITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIK

TLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDED

EEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDW

LDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSF

SGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGAL

NKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNV

NKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRT

NVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPS

VEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLV

SDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLAKALRKV

PTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGT

VSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDY

GARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYM

RSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYS

GQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRT

IKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEG

KTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVN

GLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFC

ALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQ

QTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFV

MMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALL

TKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKK

DNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPA

SRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATN

KATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPV

SEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLM

AAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPF

LNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASM

PTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYS

TAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGL

DSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAI

MQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWK

SYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGK

GFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIV

DSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPIN

VIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAV

KMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAA

RQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMT

PRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAA

KKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLF

VAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHA

DFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDF

LHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPY

CYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSE

YCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLLTN

MFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAF

NTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMV

MFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALC

TFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREA

ACCHLAKALNDFSNSGSDVLYQPPQTSITSAVLQSGFRKMAFPSGKVEG

CMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSN

HNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQT

FSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC

YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAW

LYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQ

TGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTF

QSAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFXYENAFLPFAMGII

AMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMT

WLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTL

MNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIV

FMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLG

VYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATV

QSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTE

AFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYA

AFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLE

KMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNN

IINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWE

IQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPV

ALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWA

RFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVL

GSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPIT

NCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPK

GFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLR

EPMLQSADAQSFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVA

GFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKD

CPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCD

TLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLK

TVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVD

SYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDR

YFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIF

VDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMH

AASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFK

EGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDK

YFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQD

ALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQK

LLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPK

CDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVM

CGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIAD

KYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVC

FNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCS

QHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSL

AIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTND

NTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLC

CKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKS

HKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILA

NTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKP

RPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLN

VGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQ

KVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALC

EKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTA

DIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPAPRTLLTKGTL

EPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHK

DKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISP

YNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNV

AITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCS

KVITGLHPTQAPTHLSVDTKFKTEGLCVDIPGIPKDMTYRRLISMMGFK

MNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQL

GFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLP

WNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERT

CCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQ

SNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDEL

KINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKF

YDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVC

RFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYS

DSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDA

YNMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDG

QQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPV

PEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETIC

APLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNG

VTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDF

LELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPF

ELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSV

VSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLY

KMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVP

YNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADST

LIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQ

KLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLI

GCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLR

GTAVMSLKE

SEQ ID NO:11

<xnotran> > \ S _2019-nCoV/ -INMI1 (Sprotein _ hCoV19ItalyINMI1isl 2020) (Genbank Acc.No: QIA 98554) MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT </xnotran>

SEQ ID NO:12

<xnotran> > hCoV-19//IDF0372-isl/2020|EPI_ISL_410720|2020-01-23ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTCGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTCTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACCTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACATACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAACTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAAGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGTGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGGTGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTTTCCTATATAATTCCGCATCATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGGGCAAACTGGAAAGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAGCACACCTTGTAATGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACAATCATATGGTTTCCAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGATGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAACATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAATTCTCCTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAACCGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAAGATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCAAAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAATTTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGACTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACCCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGTTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGACAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGCTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTAAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACCCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAGGGGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCAGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAA </xnotran>

SEQ ID NO:13

Severe acute respiratory syndrome coronavirus 2orf1ab polyprotein of isolate hCoV-19/France/IDF 0372-isl/2020

MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKD

GTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQY

GRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDL

GDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCG

PDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWY

TERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKK

LDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKA

TCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYH

NESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHT

GVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAF

VETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAF

ASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMF

TSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEK

FKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNK

FLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPL

KAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVC

INGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIE

VQGYKSVNITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIK

TLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDED

EEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDW

LDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSF

SGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGAL

NKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNV

NKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRT

NVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPS

VEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLV

SDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLAKALRKV

PTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGT

VSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDY

GARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYM

RSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYS

GQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRT

IKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEG

KTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVN

GLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFC

ALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQ

QTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFV

MMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALL

TKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKK

DNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPA

SRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATN

KATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPV

SEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLM

AAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPF

LNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASM

PTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYS

TAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGL

DSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAI

MQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWK

SYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGK

GFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIV

DSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPIN

VIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAV

KMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAA

RQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMT

PRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAA

KKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLF

VAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHA

DFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDF

LHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPY

CYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSE

YCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLLTN

MFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAF

NTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMV

MFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALC

TFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREA

ACCHLAKALNDFSNSGSDVLYQPPQTSITSAVLQSGFRKMAFPSGKVEG

CMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSN

HNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQT

FSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC

YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAW

LYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQ

TGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTF

QSAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGII

AMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMT

WLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTL

MNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIV

FMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLG

VYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATV

QSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTE

AFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYA

AFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLE

KMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNN

IINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWE

IQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPV

ALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWA

RFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVL

GSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPIT

NCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPK

GFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLR

EPMLQSADAQSFLNGFAV

SEQ ID NO:14

Protein \ S _ human \2019-nCoV (Sprotein _ hCoV19 FrancidF 0372isl 2020)

MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHS

TQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSN

IIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNN

KSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNI

DGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSY

LTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPL

SETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRF

ASVYAWNRKRISNCVADYSFLYNSASFSTFKCYGVSPTKLNDLCFTNVY

ADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSK

VGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQ

SYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF

NFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSF

GGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSN

VFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQS

IIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYIC

GDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTP

PIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLG

DIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAG

AALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSST

ASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEA

EVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSK

RVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGK

AHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNN

TVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDR

LNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIML

CCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT

SEQ ID NO:15

<xnotran> > hCoV-19/ /CeMM0360/2020|EPI_ISL_438123|2020-04-05NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTTGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACATACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAACTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAAGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGTGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGKCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGGTGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTCCGCATCATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGGGCAAACTGGAAAGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAGCACACCTTGTAATGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACAATCATATGGTTTCCAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGGTGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAACATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAATTCTCCTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTRATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAACCGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAAGATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCAAAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAATTTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGTTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGACTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACCCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGMCAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAATGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGCTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTAAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACCCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAAACGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCAGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGNATGACANNNNNNNNNNNNNN </xnotran>

SEQ ID NO:16

Severe acute respiratory syndrome coronavirus 2orf1ab polyprotein of isolate hCoV-19/Austria/CeMM 0360/2020

MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKD

GTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQY

GRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDL

GDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCG

PDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWY

TERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKK

LDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKA

TCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYH

NESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHT

GVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAF

VETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAF

ASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMF

TSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEK

FKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNK

FLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPL

KAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVC

INGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIE

VQGYKSVNITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIK

TLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDED

EEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDW

LDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSF

SGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGAL

NKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNV

NKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRT

NVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPS

VEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLV

SDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLAKALRKV

PTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGT

VSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDY

GARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYM

RSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYS

GQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRT

IKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEG

KTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVN

GLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFC

ALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQ

QTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFV

MMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALL

TKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKK

DNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPA

SRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATN

KATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPV

SEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLM

AAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPF

LNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASM

PTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYS

TAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGL

DSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAI

MQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWK

SYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGK

GFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIV

DSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPIN

VIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAV

KMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAA

RQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMT

PRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAA

KKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLF

VAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHA

DFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDF

LHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPY

CYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSE

YCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLLTN

MFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAF

NTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMV

MFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALC

TFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREA

ACCHLAKALNDFSNSGSDVLYQPPQTSITSAVLQSGFRKMAFPSGKVEG

CMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSN

HNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQT

FSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC

YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAW

LYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQ

TGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTF

QSAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGII

AMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMT

WLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTL

MNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIV

FMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLG

VYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATV

QSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTE

AFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYA

AFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLE

KMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNN

IINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWE

IQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPV

ALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWA

RFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVL

GSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPIT

NCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPK

GFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLR

EPMLQSADAQSFLNGFAV

SEQ ID NO:17

>SARS-CoV-2_S_MedUniWien(Sprotein_hCoV19AustriaCeMM03602020)MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRXQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSXNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRVSANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT

SEQ ID NO:18

SARS-CoV-2/human/UK/ex SA/2021 of Severe acute respiratory syndrome coronavirus 2 isolate, EVAg Ref-SKU:004V-04071 (SA _ P2) complete genome. South Africa B.1.351 lineage

ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATC

TCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTC

ACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATT

ACTGTCGTTGACAGGACACGAGTAACTCTTCTATCTTCTGCAGGCTGC

TTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTT

GTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTT

CAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTC

GCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTA

TCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGA

AGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCAT

CAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGA

GCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGA

CACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACC

GCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCAT

AGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGG

CACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATA

GCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCA

TACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCT

CTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGC

ACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATAC

TGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTC

TGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAA

AGAAATTTGACATCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTT

AAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGC

TTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACC

AAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCA

TTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTT

GCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACT

TGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCAT

GTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATA

ATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTG

CCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTG

CCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAG

GTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAA

ATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAA

ACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACA

AGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAA

ACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAG

CTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGT

CCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTT

TCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGA

AGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGAC

TCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGT

TGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTG

GCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCT

TGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAG

ACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTG

TCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTT

CAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACT

CTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAA

CATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCC

AGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAAT

TATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGG

AAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTA

GTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACG

GGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTT

GCACCTAATATGATGGTAACTAACAATACCTTCACACTCAAAGGCGGT

GCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCA

AGGTTACAAGAGTGTGAATATCACTTTTGAACTTGATGAAAGGATTGA

TAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTAC

AGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAA

CTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGA

TGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTT

AAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCCAGATGAGGATG

AAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCA

ATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATT

TGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAA

GATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGG

CAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTC

AACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAA

GTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTA

AAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGT

GGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGC

AGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGA

TGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGT

TTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCC

AAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATG

AAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTG

GTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATAC

TGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGAC

AAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGA

ACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAA

CTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAA

AATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTA

AGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCT

TCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTA

AAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTT

TTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAA

ATGTTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAAC

CACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAA

AGACAGTGCTTAAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTA

TTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATT

TGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCT

GTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATAT

AAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTT

TACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTT

AACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACA

CATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAA

GTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTAT

AATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTG

AAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGAC

AATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTG

TATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTAT

CACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGA

CTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAA

GTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTAT

TTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAA

GGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAG

GCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTAC

ATGTCAGCATTAAATCACACTAAAAATTGGAAATACCCACAAGTTAAT

GGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACT

GCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCT

CTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTT

TTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGG

TGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGA

TTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAAC

AGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACA

CTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGT

GGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTT

ATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTT

ACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAA

CATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTA

CAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAG

AAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATG

GTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGA

AAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACC

AACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAA

TATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTACAAGAAACC

TGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGA

TGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGG

AGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACT

AATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGG

AGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTC

AGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAAC

CAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTT

CTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTT

AAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACAC

AGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAA

CCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATG

GTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGC

TAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTAC

ACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTT

TATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAA

AGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGG

TAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTT

TCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCT

AGGTTCTTTAATMTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAAT

TTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAAC

TCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTA

GTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGA

AACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTT

GGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTT

TCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTT

TGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATC

TTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTT

TGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGT

TGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACA

AGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTAT

GTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAAT

TGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATG

AAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCT

ACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGT

TCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGA

CATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAAC

ACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAA

AATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGC

TTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGT

TGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAA

TACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACT

AGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACA

ATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTC

AGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCA

ATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACC

TATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATT

GACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAA

CATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACA

ACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTT

TAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAAC

AAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCA

GTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATT

TAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTG

AAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAG

CATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACAT

GGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCAT

TGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGT

TTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCT

TACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAA

AACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTG

CTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTG

TTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGC

CCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTA

ACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTG

AGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGT

GTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTT

TACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTATTTACTAATAT

GTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCT

ATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTTGCCTACT

ATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTG

CCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACA

CCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTT

GACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGA

TGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATAT

CATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAA

AGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAG

CTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGC

GTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTT

TATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTAC

AGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAG

TAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCAC

CTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGG

TAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACT

TAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGAT

CTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACTCATT

CGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTC

AGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAGGGTT

GATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAA

CCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCT

GGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTATTAAGGGTTCAT

TCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTG

TGTCTCTTTTTKTTACATGCACCATATGGAATTACCAACTGGAGTTCAT

GCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAG

GCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATG

TTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTC

TCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAA

GTACAATTATGAACYTCTAACACAAGACCATGTTGACATACTAGGACC

TCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTA

AAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGT

GCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCT

CAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACA

CACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCC

AGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTT

ACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTG

TCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGC

CACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATG

CGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGNNNNNNAAG

CTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTA

TGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACA

CTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTT

AGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAAC

TACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTT

TTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACT

TCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTT

ACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTG

GTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTC

ACAGGGACTAYTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCA

ACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCA

CTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTAC

TCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGG

CTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTA

CTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCA

TGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGAC

AACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCA

TCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTT

GCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTG

AATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAG

TTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCT

AGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAAT

GCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACAT

TATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCT

TACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATA

TAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTG

GGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAG

TGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTA

ACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTT

AGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACA

AACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAA

AGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGA

AATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATCTATACAG

AACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCT

AAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGA

GGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGT

AATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCT

TTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGG

GGACAACCAATCACTAATTGTGTTAAGATGTTGTGTA

CACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAAT

ATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGT

TGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGT

AAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTT

ACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTA

TGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGA

TGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTT

ACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTT

GACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACT

AATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGAT

TCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAA

GAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACAT

GACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCA

CGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTA

AGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTC

ACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATG

ATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTG

AACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCA

TGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATC

TCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAG

GTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATA

TTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGA

CTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCAC

GGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCA

GACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCT

GCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACA

AGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTT

GTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAAT

CAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTT

GTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTAC

TAGATAAACGCACTACGTGCTTTTCAGT

AGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAA

TTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAA

GGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATG

GTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAAC

AATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAA

GTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATC

GTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGT

AAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCA

CTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGA

ATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTG

GTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATT

ATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAAC

AAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAG

TGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGAT

AGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCT

CGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTA

GCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGT

TCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACT

GCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATG

TTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGT

CCGCAATTTACAAC

ACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACT

TTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGAT

ACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCA

AGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCA

AAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACC

TTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTA

AACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAA

TCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTA

CACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACT

TACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTA

CAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGA

CATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAA

CCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCT

GTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGT

GCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATG

TCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTG

CAATGCTTCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGG

AGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCA

TTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTG

GTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGA

CAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCA

AGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAA

CTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAA

TTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGA

AATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAA

ATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGT

TTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGT

GCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCC

ACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATAT

CTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTAT

GCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTC

ATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTAT

ACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTA

AAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTC

GTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGT

ATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAG

TTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGT

CAATGCCAGATTACGTGCTAAGCACTATGTGTACATTGGCGACCCTGC

TCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAAC

CAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAG

ACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACA

CTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACA

AATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGA

TGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATT

CCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTA

TAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCA

AACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACT

CAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTT

GCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGA

GACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGG

AATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGA

TTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACA

CCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACAT

ACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGAT

GGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATC

ACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGAT

GTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCT

TTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACA

GGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTA

AACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACA

AAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAA

GTG

ACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCAC

ATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTG

AGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTG

CTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGT

CTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAAC

CTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACAT

GTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAG

TGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTG

ATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTT

GTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATT

GGTAACCC

TAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTA

TGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATT

CTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTA

TTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTA

GATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATG

GTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTG

ATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCT

GACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGA

TTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGT

GGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGAT

GCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAA

CAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGT

TTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGA

CAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACA

AAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTA

CCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCA

GTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCT

AATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCT

ACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAACTGAA

ACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGT

CAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAA

GGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAG

TCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCA

ATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTT

ACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAA

ATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGT

ATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAG

TCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACG

TTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGT

ACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAG

TGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAAT

AAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTAT

TGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTA

GAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGG

TGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAA

GTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCAT

AATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACAC

ATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCT

GGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTG

GTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGT

CTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATAC

AGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACT

AAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTA

CATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGC

TATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATG

GGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCA

TCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCG

AACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAA

TACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAA

TTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGT

CAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAAT

TAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAA

CTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAG

TCAGTGTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACAC

TAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCC

TCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATG

TTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGA

GGTTTGCTAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTC

CACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTT

AGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTT

GTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTG

TTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGA

GTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTT

TTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGG

GAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCA

CACGCCTATTAATTTAGTGCGTGGTCTCCCTCAGGGTTTTTCGGCTTTA

GAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAA

ANNNNNNCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCA

GGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCT

AGGACTTTTCTATTAAAATATAATGAAA

ATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAG

AAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTAT

CAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTT

CCTAATATTACAAACTTGTGCCCTTTTGGTGAAGTTTTTAACGCCACC

AGATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTG

TGTTGCTGATTATTCTGTCCTATATAATTCCGCATCATTTTCCACTTTTA

AGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAA

TGTCTATGCAGATTCATTTGTAATTAGAGGTGATGAAGTCAGACAAAT

CGCTCCAGGGCAAACTGGAAATATTGCTGATTATAATTATAAATTACCA

GATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAATCTTGATT

CTAAGGTTGGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTC

TAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGC

CGGTAGCACACCTTGTAATGGTGTTAAAGGTTTTAATTGTTACTTTCCT

TTACAATCATATGGTTTCCAACCCACTTATGGTGTTGGTTACCAACCAT

ACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTG

TTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCA

ATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTA

ACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGAC

ACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATT

ACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAAT

ACTTCTAACCAGGTTGCTGTTCTTTATCAGGGTGTTAACTGCACAGAA

GTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTT

ATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAG

GGGCTGAACATGTCAACAACTCATATGAGTGTGACATACCCATTGGTG

CAGGTATATGCGCTAGTTATCAGACTCAGACTAATTCTCCTCGGCGGG

CACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTG

GTGTAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCAC

AAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACC

AAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAA

TGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAAC

CGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGA

AGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAAG

ATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACC

AAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACAC

TTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATAT

TGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGT

TTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGC

ACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTG

CTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGG

TATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGC

CAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTC

CACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCAAAAT

GCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAATTTTGGT

GCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTT

GAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAG

TTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAG

AGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGG

ACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTC

CTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTAT

GTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCA

TGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATG

GCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATC

ATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATA

GGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGAC

TCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCA

GATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACA

TTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAAT

GAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATA

AAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCA

TAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTG

TCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGA

CGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAA

CGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAAC

TTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCG

CGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCT

TATTGTTGGCGTTGCACTTCTTGCTGTTTTTCATAGCGCTTCCAAAATC

ATAACCCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCA

CTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTT

TTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTT

TAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGC

TTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATG

CCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCT

TACAATAGTGTAACTTCTTCAATTGTCATTACTTTAGGTGATGGCACAA

CAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAA

AATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCA

CTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTG

GTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCC

TGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTG

TTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTA

GCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCAT

TC

GTTTCGGAAGAGACAGGTACGTTAATAGTTAATAGCGTACTTCTTTTT

CTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGC

TTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAA

AACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAG

AGTTCTTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCT

GTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACC

GTTGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAATAGG

TTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAAC

AGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATG

GCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAA

TTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTT

GATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTAC

GCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAACGT

GCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAAC

TCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGAC

ACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACT

GTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAG

CGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATT

GGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATT

GCTTTGCTTGTACAGTAAGCGACAACAGATGTTTCATCTCGTTGACTT

TCAGGTTACTATAGCAGAGATATTACTAATTATTATGAGGACTTTTAAA

GTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATT

TATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGC

AACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTTCTTGG

CACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTG

TTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACAT

ACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCAC

TGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAA

AACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCA

TCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTG

TTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAG

ACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGC

CTTTCTGCTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACT

TGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGA

AATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCA

AGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGAT

GACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAG

CTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTT

CTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTG

TTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTA

GTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGT

GTTGTTTTAGATTTTATCTAAACGAACAAACTAAAATGTCTGATAATG

GACCCCAAAATCAGCGAAATGCACCCCGCATTACGTTTGGTGGACCC

TCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGC

GATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTT

GGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCT

CGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCA

AATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACG

GTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAA

CTGGGCCAGAAGCTGGACTT

CCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGG

AGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTA

ACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCA

AAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTT

CTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCA

GGCAGCAGTAGGGGAATTTCTCCTGCTAGAATGGCTGGCAATGGCGG

TGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGA

GAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTC

ACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACG

TACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTG

GTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAG

ACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCC

CCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTC

ACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGA

TGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCA

TATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACA

AAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAA

GAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTT

CTCCAAACAATTGCAACAATCCATGAGCAGTGCTGACTCAACTCAGG

CCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTT

TCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTC

TCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAG

CAATCTTTAATC

AGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACC

GAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGG

AGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTA

GTGCTATCCCCATGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNAA

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

SEQ ID NO:19

<xnotran> > SA _ P2_ gp02 , SA _ P2_ t0.9_ q20MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFANPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRGLPQGFSALEPLVDLPIGINITRFQXXXLHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVKGFNCYFPLQSYGFQPTYGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGVENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT </xnotran>

SEQ ID NO:20

> MW520923.1 Severe acute respiratory syndrome coronavirus 2 isolate SARS-CoV-2/human/USA/MN-MDH-2399/2021, complete genome, brazil P1 lineage exemplification.

CAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCT

GTGTGGCTGTCACTCGGCTGCATGCTTAGTG

CACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACAC

GAGTAACTCGTCTATCTTCTGCAGGCTGCTTA

CGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTTGTC

CGGGTGTGACCGAAAGGTAAGATGGAGAGCCT

TGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTG

TTTTACAGGTTCGCGACGTGCTCGTACGTGGCT

TTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTT

AAAGATGGCACTTGTGGCTTAGTAGAAGTTGAA

AAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGT

TCGGATGCTCGAACTGCACCTCATGGTCATGT

TATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTA

GTGGTGAGACACTTGGTGTCCTTGTCCCTCATG

TGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAAC

GGTAATAAAGGAGCTGGTGGCCATAGTTACGGC

GCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCT

TATGAAGACTTTCAAGAAAACTGGAACACTAA

ACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAG

GGGCATACACTCGCTATGTCGATAACAACTTCT

GTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCAC

GTGCTGGTAAAGCTTCATGCACTTTGTCCGAA

CAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGA

ACATGAGCATGAAATTGCTTGGTACACGGAACG

TTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGC

AAAGAAATTTGACACCTTCAATGGGGAATGTC

CAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAG

GGTTGAAAAGAAAAAGCTTGATGGCTTTATG

GGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAAC

CAAATGTGCCTTTCAACTCTCATGAAGTGTGA

TCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCA

CTTGCGAATTTTGTGGCACTGAGAATTTGACTA

AAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTA

AAATTTATTGTCCAGCATGTCACAATTCAGAA

GTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTG

AAAACCATTCTTCGTAAGGGTGGTCGCACTAT

TGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTG

TGCCTATTGGGTTCCACGTGCTAGCGCTAACA

TAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTT

AATGACAACCTTCTTGAAATACTCCAAAAAGAG

AAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATC

GCCATTATTTTGGCATCTTTTTCTGCTTCCAC

AAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCA

AACAAATTGTTGAATCCTGTGGTAATTTTAAAG

TTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACA

GAAATCAATACTGAGTCCTCTTTATGCATTTGCA

TCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAA

ACTGCTCAAAATTCTGTGCGTGTTTTACAGAA

GGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACT

CATTGATGCTATGATGTTCACATCTGATTTGG

CTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTC

AGTTGACTTCGCAGTGGCTAACTAACATCTTT

GGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGA

GAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGA

CGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGT

CGGTGGACAAATTGTCACCTGTGCAAAGGAAA

TTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGG

CTTTGTGTGCTGACTCTATCATTATTGGTGGA

GCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCA

AAGGGATTGTACAGAAAGTGTGTTAAATCCAG

AGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTA

TCTTCTTAGAGGGAGAAACACTTCCCACAGAAG

TGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTA

GAACAACCTACTAGTGAAGCTGTTGAAGCTCCA

TTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATC

AAAGACACAGAAAAGTACTGTGCCCTTGCACC

TAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACC

AACAAAGGTTACTTTTGGTGATGATACTGTGA

TAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGAT

GAAAGGATTGATAAAGTACTTAATGAGAAGTGC

TCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGT

GTTGTGGCAGATGCTGTCATAAAAACTTTGCA

ACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTG

GAGTATGGCTACATACTACTTATTTGATGAGT

CTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCC

AGATGAGGATGAAGAAGAAGGTGATTGTGAA

GAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGA

TGATTACCAAGGTAAACCTTTGGAATTTGGTGC

CACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGT

TAGATGATGATAGTCAACAAACTGTTGGTCAAC

AAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTT

GAGGTTCAACCTCAATTAGAGATGGAACTTACA

CCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAA

CTTACTGACAATGTATACATTAAAAATGCAGA

CATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATG

CAGCCAATGTTTACCTTAAACATGGAGGAGGTG

TTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAAT

CTGATGATTACATAGCTACTAATGGACCACTT

AAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACA

CTGTCTTCATGTTGTCGGCCCAAATGTTAACAA

AGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCA

GCACGAAGTTCTACTTGCACCATTATTATCAG

CTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGA

TACTGTTCGCACAAATGTCTACTTAGCTGTC

TTTGATAAAAATCTCTATGACAAACTTGTTTTAAGCTTTTTGGAAATG

AAGAGTGAAAAGCAAGTTGAACAAAAGATCGC

TGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAAC

CTTCAGTTGAACAGAGAAAACAAGATGATAAGA

AAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACT

AAGTTCCTCACAGAAAACTTGTTACTTTATATT

GACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACA

TTGACATCACTTTCTTAAAGAAAGATGCTCC

ATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGT

TATACCTACTAAAAAGGCTGGTGGCACTACTG

AAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATA

ACCACTTACCCGGGTCAGGGTTTAAATGGTTAC

ACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCCT

TTTACATTCTACCATCTATTATCTCTAATGAGAA

GCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTG

CACATGCAGAAGAAACACGCAAATTAATGCCTG

TCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATA

AGGGTATTAAAATACAAGAGGGTGTGGTTGAT

TATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCA

CTTATCAACACACTTAACGATCTAAATGAAAC

TCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGA

AGAAGCTGCTCGGTATATGAGATCTCTCAAAG

TGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAA

TGGTTATCTTACTTCTTCTTCTAAAACACCT

GAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGAT

TGGTCCTATTCTGGACAATCTACACAACTAGG

TATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAAT

CCTACCACATTCCACCTAGATGGTGAAGTTA

TCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGG

ACTATTAAGGTGTTTACAACAGTAGACAACATT

AACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACA

GTTTGGTCCAACTTATTTGGATGGAGCTGATGT

TACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTT

TTACCTAATGATGACACTCTACGTGTTGAGG

CTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACA

TGTCAGCATTAAATCACACTAAAAAGTGGAAA

TACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAAC

TGTTATCTTGCCACTGCATTGTTAACACTCCA

ACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTA

CAGAGCAAGGGCTGGTGAAGCTGCTAACTTTT

GTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTG

ATGTTAGAGAAACAATGAGTTACTTGTTTCAA

CATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAA

ACTTGTGGACAACAGCAGACAACCCTTAAGGG

TGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAA

GAAAGGTGTTCAGATACCTTGTACGTGTGGTA

AACAAGCTACACAATATCTAGTACAACAGGAGTCACCTTTTGTTATGA

TGTCAGCACCACCTGCTCAGTATGAACTTAAG

CATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGT

GGTCACTATAAACATATAACTTCTAAAGAAAC

TTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAA

AGGTCCTATTACGGATGTTTTCTACAAAGAAA

ACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTG

TTGTTTGTACAGAAATTGACCCTAAGTTGGAC

AATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGAT

CTTGTACCAAACCAACCATATCCAAACGCAAG

CTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATT

TAAACCAGTTAACTGGTTATAAGAAACCTG

CTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATG

TGGTGGCTATTGATTATAAACACTACACACCC

TCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCAT

GTTAACAATGCAACTAATAAAGCCACGTATAA

ACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCGGTTG

AAACATCAAATTCGTTTGATGTACTGAAGTCAG

AGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCA

GTCTCTGAAGAAGTAGTGGAAAATCCTACCATA

CAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGG

AGACATTATACTTAAACCAGCAAATAATAGTTT

AAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGT

AGACAATTCTAGTCTTACTATTAAGAAACCTA

ATGAATTATCTAGAGTGTTAGGTTTGAAAACCCTTGCTACTCATGGTTT

AGCTGCTGTTAATAGTGTCCCTTGGGATACT

ATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTA

CTAACATAGTTACACGGTGTTTAAACCGTGT

TTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTAC

TTTTACTAGAAGTACAAATTCTAGAATTA

AAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCG

GTAAATTTTGTCTAGAGGCTTCATTTAATTAT

TTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTT

ACTATTAAGTGTTTGCCTAGGTTCTTTAAT

CTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCT

TCTTACTGTACTGGTTACAGAGAAGGCTATT

TGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACC

TTGTAGTGTTTGTCTTAGTGGTTTAGATTCT

TTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTT

TTAAATGGGATTTAACTGCTTTTGGCTTAGT

TGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTA

CTTGGATTGGCTGCAATCATGCAATTGTTTT

TCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTA

ATAATTAATCTTGTACAAATGGCCCCGATT

TCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATG

GAAAAGTTATGTGCATGTTGTAGACGGTTG

TAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAG

AGTCGAATGTACAACTATTGTTAATGGTGTTA

GAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAAC

TACACAATTGGAATTGTGTTAATTGTGATACA

TTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTG

TCACTACAGTTTAAAAGACCAATAAATCCTAC

TGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTC

CATCCATCTTTACTTTGATAAAGCTGGTCAAA

AGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACC

TGAGAGCTAATAACACTAAAGGTTCATTGCCT

ATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTG

CAAAATCAGCGTCTGTTTACTACAGTCAGCT

TATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTT

GGTGATAGTGCGGAAGTTGCAGTTAAAATGT

TTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGA

AAAACTCAAAACACTAGTTGCAACTGCAGAA

GCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTA

TTTCAGCAGCTCGGCAAGGGTTTGTTGATTC

AGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCA

ATCTGACATAGAAGTTACTGGCGATAGTTGTA

ATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTG

ACCTTGGTGCTTGTATTGACTGTAGTGCGCGT

CATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGG

AACGTTAAAGATTTCATGTCATTGTCTGAACA

ACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTT

TAAGTTGACATGTGCAACTACTAGACAAGTTG

TTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTA

ATAATTGGTTGAAGCAGTTAATTAAAGTTACA

CTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCA

TGTCATGTCTAAACATACTGACTTTTCAAG

TGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACAT

AGCATCTACAGATACTTGTTTTGCTAACAAAC

ATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTA

ATGACAAAGCTTGCCCATTGATTGCTGCAGTC

ATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGAT

ATTACGCACAACTAATGGTGACTTTTTGCATTT

CTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATC

AAAACTTATAGAGTACACTGACTTTGCAACAT

CAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTG

GTAAGCCAGTACCATATTGTTATGATACCAAT

GTACTAGAAGGTTCTGTTGCTTATGAAAATTTACGCCCTGACACACGT

TATGTGCTCATGGATGGCTCTATTATTCAATT

TCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGA

TTCTGAGTACTGTAGGCACGGCACTTGTGAAA

GATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTA

ACAATGATTATTACAGATCTTTACCAGGAGTT

TTCTGTGGTGTAGATGCTGTAAATTTACTTACTAATATGTTTACACCAC

TAATTCAACCTATTGGTGCTTTGGACATATC

AGCATCTATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTT

GCCTACTATTTTATGAGGTTTAGAAGAGCTT

TTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATG

TCATTCACTGTACTCTGTTTAACACCAGTT

TACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATT

TTATCTTACTAATGATGTTTCTTTTTTAGC

ACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATA

ACAATTGCTTATATCATTTGTATTTCCACAA

AGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTT

TAATGGTGTTTCCTTTAGTACTTTTGAAGAA

GCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTG

CGTAGTGATGTGCTATTACCTCTTACGCAATA

TAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCA

ATGGATACAACTAGCTACAGAGAAGCTGCTT

GTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTG

ATGTTCTTTACCAACCACCACAAACCTCTATC

ACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCT

GGTAAAGTTGAGGGTTGTATGGTACAAGTAAC

TTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTA

CTGTCCAAGACATGTGATCTGCACCTCTGAAG

ACATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCA

TAATTTCTTGGTACAGGCTGGTAATGTTCAA

CTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAG

GTTGATACAGCCAATCCTAAGACACCTAAGTA

TAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTG

TTACAATGGTTCACCATCTGGTGTTTACCAAT

GTGCTATGAGGCCCAATTTCACTATTAAGGGTTCATTCCTTAATGGTTC

ATGTGGTAGTGTTGGTTTTAACATAGATTAT

GACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGA

GTTCATGCTGGCACAGACTTAGAAGGTAACTT

TTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGG

ACACAACTATTACAGTTAATGTTTTAGCTTGGT

TGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTA

CCACAACTCTTAATGACTTTAACCTTGTGGCT

ATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTA

GGACCTCTTTCTGCTCAAACTGGAATTGTCGT

TTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAAT

GGACGTACCATATTGGGTAGTGCTTTATTAG

AAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTA

CTTTCCAAAGTGCAGTGAAAAGAACAATCAAG

GGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTT

TTAGTCCAGAGTACTCAATGGTCTTTGTTCTT

TTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTA

TGTCTGCTTTTGCAATGATGTTTGTCAAAC

ATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGT

AGCTTATTTTAATATGGTCTATATGCCTGCT

AGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTT

TGAAGCTAAAAGACTGTGTTATGTATGCATC

AGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGA

TGGTGCTAGGAGAGTGTGGACACTTATGAATG

TCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGC

CATTTCCATGTGGGCTCTTATAATCTCTGTT

ACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGA

GGTATTGTTTTTATGTGTGTTGAGTATTGCCC

TATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATT

GTTTCTTAGGCTATTTTTGTACTTGTTACT

TTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTG

TTTATGATTACTTAGTTTCTACACAGGAGTTT

AGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGAT

GCCTTCAAACTCAACATTAAATTGTTGGGTGT

TGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTC

AGATGTAAAGTGCACATCAGTAGTCTTACTCT

CAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTC

AATGTGTCCAGTTACACAATGACATTCTCTTA

GCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCT

GTTTTGCTTTCCATGCAGGGTGCTGTAGACAT

AAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAA

GCTATAGCCTCAGAGTTTAGTTCCCTTCCATCAT

ATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTA

ATGGTGATTCTGAAGTTGTTCTTAAAAAGTTG

AAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCC

ATGCAACGTAAGTTGGAAAAGATGGCTGATCA

AGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGG

CAAAAGTTACTAGTGCTATGCAGACAATGCTTT

TCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCA

ACAATGCAAGAGATGGTTGTGTTCCCTTGAAC

ATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGAC

TATAACACATATAAAAATACGTGTGATGGTAC

AACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGA

TGCAGATAGTAAAATTGTTCAACTTAGTGAAA

TTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGC

TTTAAGGGCCAATTCTGCTGTCAAATTACAG

AATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCC

GGTACTACACAAACTGCTTGCACTGATGACAA

TGCGTTAGCTTATTACAACACAACAAAGGGAGGTAGGTTTGTACTTG

CACTGTTATCCGATTTACAGGATTTGAAATGGG

CTAGATTCCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACTGG

AACCACCTTGTAGGTTTGTTACAGACACACCT

AAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAAC

CTAAATAGAGGTATGGTACTTGGTAGTTTAGC

TGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCA

ATTCAACTGTATTATCTTTCTGTGCTTTTGCTG

TAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAAC

CAATCACTAATTGTGTTAAGATGTTGTGTACA

CACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATAT

GGATCAAGAATCCTTTGGTGGTGCATCGTGTTG

TCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTG

TGACTTAAAAGGTAAGTATGTACAAATACCTA

CAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCT

GTACCGTCTGCGGTATGTGGAAAGGTTATGGC

TGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCA

CAATCGTTTTTAAACGGGTTTGCGGTGTAAGT

GCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGT

ATACAGGGCTTTTGACATCTACAATGATAAAGT

AGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGA

AAAGGACGAAGATGACAATTTAATTGATTCTT

ACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAA

ACAATTTATAATTTACTTAAGGATTGTCCAGCT

GTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTA

CCACATATATCACGTCAACGTCTTACTAAATA

CACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAA

TTGTGATACATTAAAAGAAATACTTGTCACAT

ACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTT

TGTAGAAAACCCAGATATATTACGCGTATAC

GCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACA

ATTCTGTGATGCCATGCGAAATGCTGGTATTGT

TGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGAT

TTCGGTGATTTCATACAAACCACGCCAGGTA

GTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTA

ACCTTGACCAGGGCTTTAACTGCAGAGTCA

CATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTA

AAATATGACTTCACGGAAGAGAGGTTAAAACT

CTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGT

GTTAACTGTTTGGATGACAGATGCATTCTGC

ATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAG

TTTTGGACCACTAGTGAGAAAAATATTTGTT

GATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTA

GGTGTTGTACATAATCAGGATGTAAACTTACA

TAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCT

GCTATGCACGCTGCTTCTGGTAATCTATTAC

TAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATG

TTGCTTTTCAAACTGTCAAACCCGGTAATTTT

AACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAA

GGAAGTTCTGTTGAATTAAAACACTTCTTCTT

TGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTAT

AATCTACCAACAATGTGTGATATCAGACAAC

TACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGG

TGGCTGTATTAATGCTAACCAAGTCATCGTC

AACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAG

GCTAGACTTTATTATGATTCAATGAGTTATGA

GGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACT

ATAACTCAAATGAATCTTAAGTATGCCATTA

GTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTA

CTATGACCAATAGACAGTTTCATCAAAAATTA

TTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAAC

AAGCAAATTCTATGGTGGTTGGCACAACATGTT

AAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGA

TTATCCTAAATGTGATAGAGCCATGCCTAACA

TGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGT

GTTGTAGCTTGTCACACCGTTTCTATAGATTA

GCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGT

TCACTATATGTTAAACCAGGTGGAACCTCATC

AGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCA

AGCTGTCACGGCCAATGTTAATGCACTTTTAT

CTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAAC

ACAGACTTTATGAGTGTCTCTATAGAAATAGA

GATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAA

CATTTCTCAATGATGATACTCTCTGACGATGC

TGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAG

CATAAAGAACTTTAAGTCAGTTCTTTATTATC

AAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGAC

CTTACTAAAGGACCTCATGAATTTTGCTCTCAA

CATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACC

CAGATCCATCAAGAATCCTAGGGGCCGGCTG

TTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACG

GTTCGTGTCTTTAGCTATAGATGCTTACCCAC

TTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTT

ACAATACATAAGAAAGCTACATGATGAGTTA

ACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACA

CTTCAAGGTATTGGGAACCTGAGTTTTATGA

GGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGT

TCTTTGCAATTCACAGACTTCATTAAGATGTG

GTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCA

TGTCATATCAACATCACATAAATTAGTCTTG

TCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGAT

GTGACTCAACTTTACTTAGGAGGTATGAGCTA

TTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAAT

GGACAAGTTTTTGGTTTATATAAAAATACAT

GTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTG

ACTGGACAAATGCTGGTGATTACATTTTAGCT

AACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAA

AGCTACTGAGGAGACATTTAAACTGTCTTATGG

TATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTC

ATGGGAAGTTGGTAAACCTAGACCACCACTTA

ACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAG

TACAAATAGGAGAGTACACCTTTGAAAAAGGT

GACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTA

AATGTTGGTGATTATTTTGTGCTGACATCACA

TACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTA

TGTTAGAATTACTGGCTTATACCCAACACTCA

ATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTG

GTATGCAAAAGTATTCTACACTCCAGGGACCA

CCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACC

CTTCTGCTCGCATAGTGTATACAGCTTGCTC

TCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCT

ATAGATAAATGTAGTAGAATTATACCTGCAC

GTGCTCGTGTAGATTGTTTTGATAAATTCAAAGTGAATTCAACATTAG

AACAGTATGTCTTTTGTACTGTAAATGCATTG

CCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCC

ACAAATTATGATTTGAGTGTTGTCAATGCCAG

ATTACGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACC

TGCACCACGCACATTGCTAACTAAGGGCACAC

TAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAG

GTCCAGACATGTTCCTCGGAACTTGTCGGCGT

TGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAAT

AAGCTTAAAGCACATAAAGACAAATCAGCTCA

ATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCT

GCAATTAACAGGCCACAAATAGGCGTGGTAA

GAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTT

CACCTTATAATTCACAGAATGCTGTAGCCTCA

AAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTC

AGAATATGACTATGTCATATTCACTCAAACCAC

TGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTAC

CAGAGCAAAAGTAGGCATACTTTGCATAATGT

CTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTC

CACGTAGGAATGTGGCAACTTTACAAGCTGAA

AATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTA

CATCCTACACAGGCACCTACACACCTCAGTGT

TGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACATACCTGGCAT

ACCTAAGGACATGACCTATAGAAGACTCATCT

CTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACAT

GTTTATCACCCGCGAAGAAGCTATAAGACAT

GTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGA

GAAGCTGTTGGTACCAATTTACCTTTACAGCT

AGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTT

GATACACCTAATAATACAGATTTTTCCAGAG

TTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCAC

TTATGTACAAAGGACTTCCTTGGAATGTAGTG

CGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCT

GACAGAGTCGTATTTGTCTTATGGGCACATGG

CTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCG

CACCTGTTGTCTATGTGATAGACGTGCCACAT

GCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGG

ATTTGATTACGTCTATAATCCGTTTATGATT

GATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGA

TCTGTATTGTCAAGTCCATGGTAATGCACATGT

AGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTG

CTTTGTTAAGCGTGTTGACTGGACTATTGAAT

ATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGG

TTCAACACATGGTTGTTAAAGCTGCATTATTA

GCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATT

AAGTGTGTACCTCAAGCTGATGTAGAATGGAA

GTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGA

ATTATTCTATTCTTATGCCACACATTCTGACA

AATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATA

TCCTGCTAATTCCATTGTTTGTAGATTTGAC

ACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGT

TTGTATGTAAATAAACATGCATTCCACACACC

AGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTC

TATTACTCTGACAGTCCATGTGAGTCTCATG

GAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTA

CGTGTATAACACGTTGCAATTTAGGTGGTGCT

GTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATA

ACATGATGATCTCAGCTGGCTTTAGCTTGTG

GGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAG

ACTTCAGAGTTTAGAAAATGTGGCTTTTAATG

TTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTT

TCTATCATTAATAACACTGTTTACACAAAAGTT

GATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTT

AATGTAGCATTTGAGCTTTGGGCTAAGCGCAA

CATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGG

ACATTGCTGCTAATACTGTGATCTGGGACTACA

AAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGAC

TGACATAGCCAAGAAACCAACTGAAACGATT

TGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTA

GACTTATTTAGAAATGCCCGTAATGGTGTTCT

TATTACAGAAGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAA

ACAAGCTAGTCTTAATGGAGTCACATTAATTG

GAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGT

GTTGTCCAACAATTACCTGAAACTTACTTTACT

CAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAAT

TGATTTCTTAGAATTAGCTATGGATGAATTCAT

TGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGG

AGATTTTAGTCATAGTCAGTTAGGTGGTTTAC

ATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATT

AGAAGATTTTATTCCTATGGACAGTACAGTT

AAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTG

TGTTCTGTTATTGATTTATTACTTGATGATTT

TGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTC

AAAGTGACTATTGACTATACAGAAATTTCAT

TTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAAT

TACAATCTAGTCAAGCGTGGCAACCGGGTGTT

GCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGT

GACCTTCAAAATTATGGTGATAGTGCAACATT

ACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCA

ATATTTAAACACATTAACATTAGCTGTACCCT

ATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGC

ACCAGGTACAGCTGTTTTAAGACAGTGGTTG

CCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCT

GATGCAGATTCAACTTTGATTGGTGATTGTGC

AACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTAC

GACCCTAAGACTAAAAATGTTACAAAAGAAA

ATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAAC

AAAAGCTAGCTCTTGGAGGTTCCGTGGCTATA

AAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGA

CACTTCGCATGGTGGACAGCCTTTGTTACTAA

TGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTT

GGCAAACCACGCGAACAAATAGATGGTTATG

TCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTT

GTCTTCCTATTCTTTATTTGACATGAGTAAA

TTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGT

CAAATCAATGATATGATTTTATCTCTTCTTAG

TAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAG

TGATGTTCTTGTTAACAACTAAACGAACAATG

TTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATTT

TACAAACAGAACTCAATTACCCTCTGCATA

CACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAG

ATCCTCAGTTTTACATTCAACTCAGGACTTGT

TCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCT

GGGACCAATGGTACTAAGAGGTTTGATAAC

CCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGT

CTAACATAATAAGAGGCTGGATTTTTGGTAC

TACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACT

AATGTTGTTATTAAAGTCTGTGAATTTCAAT

TTTGTAATTATCCATTTTTGGGTGTTTATTACCACAAAAACAACAAAA

GTTGGATGGAAAGTGAGTTCAGAGTTTATTCT

AGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGG

ACCTTGAAGGAAAACAGGGTAATTTCAAAAA

TCTTAGTGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATT

CTAAGCACACGCCTATTAATTTAGTGCGTG

ATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAAT

AGGTATTAACATCACTAGGTTTCAAACTTTA

CTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTT

GGACAGCTGGTGCTGCAGCTTATTATGTGGG

TTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACC

ATTACAGATGCTGTAGACTGTGCACTTGACC

CTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAA

GGAATCTATCAAACTTCTAACTTTAGAGTCCAA

CCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTT

TTGGTGAAGTTTTTAACGCCACCAGATTTGC

ATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTG

ATTATTCTGTCCTATATAATTCCGCATCATTTT

CCACTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTG

CTTTACTAATGTCTATGCAGATTCATTTGTA

ATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGGGCAAACTGGAAC

GATTGCTGATTATAATTATAAATTACCAGATGA

TTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAATCTTGATTCTAAG

GTTGGTGGTAATTATAATTACCTGTATAGAT

TGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTG

AAATCTATCAGGCCGGTAGCACACCTTGTAAT

GGTGTTAAAGGTTTTAATTGTTACTTTCCTTTACAATCATATGGTTTCC

AACCCACTTATGGTGTTGGTTACCAACCATA

CAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGT

TTGTGGACCTAAAAAGTCTACTAATTTGGTTA

AAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGT

GTTCTTACTGAGTCTAACAAAAAGTTTCTGCCT

TTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGT

GATCCACAGACACTTGAGATTCTTGACATTAC

ACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATAC

TTCTAATCAGGTTGCTGTTCTTTATCAGGGTG

TTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTC

CTACTTGGCGTGTTTATTCTACAGGTTCTAAT

GTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAATATGTCAAC

AACTCATATGAGTGTGACATACCCATTGGTGC

AGGTATATGCGCTAGTTATCAGACTCAGACTAATTCTCCTCGGCGGGC

ACGTAGTGTAGCTAGTCAATCCATCATTGCCT

ACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACT

CTATTGCCATACCCACAAATTTTACTATTAGT

GTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGAT

TGTACAATGTACATTTGTGGTGATTCAACTGA

ATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAA

CCGTGCTTTAACTGGAATAGCTGTTGAACAAG

ACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAA

AACACCACCAATTAAAGATTTTGGTGGTTTTAAT

TTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTT

ATTGAAGATCTACTTTTCAACAAAGTGACACT

TGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATT

GCTGCTAGAGACCTCATTTGTGCACAAAAGT

TTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTG

CTCAATACACTTCTGCACTGTTAGCGGGTACA

ATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCA

TTTGCTATGCAAATGGCTTATAGGTTTAATGG

TATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGC

CAACCAATTTAATAGTGCTATTGGCAAAATTC

AAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGAT

GTGGTCAACCAAAATGCACAAGCTTTAAACACG

CTTGTTAAACAACTTAGCTCCAATTTTGGTGCAATTTCAAGTGTTTTA

AATGATATCCTTTCACGTCTTGACAAAGTTGA

GGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTT

TGCAGACATATGTGACTCAACAATTAATTAGAG

CTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTATTAAAATGTCAG

AGTGTGTACTTGGACAATCAAAAAGAGTTGAT

TTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCT

CATGGTGTAGTCTTCTTGCATGTGACTTATGT

CCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATG

ATGGAAAAGCACACTTTCCTCGTGAAGGTGTCT

TTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATG

AACCACAAATCATTACTACAGACAACACATTT

GTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTT

TATGATCCTTTGCAACCTGAATTAGACTCATT

CAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGT

TGATTTAGGTGACATCTCTGGCATTAATGCTT

CATTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCC

AAGAATTTAAATGAATCTCTCATCGATCTCCAA

GAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGG

CTAGGTTTTATAGCTGGCTTGATTGCCATAGT

AATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCT

CAAGGGCTGTTGTTCTTGTGGATCCTGCTGCA

AATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTA

CATTACACATAAACGAACTTATGGATTTGTTTA

TGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATC

AAGGATGCTACTCCTTCAGATTTTGTTCGCGCT

ACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATT

GTTGGCGTTGCACTTCTTGCTGTTTTTCAGAG

CGCTTCCAAAATCATAACCCTCAAAAAGAGATGGCAACTAGCACTCT

CCAAGGGTGTTCACTTTGTTTGCAACTTGCTGT

TGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCC

TTGAAGCCCCTTTTCTCTATCTTTATGCTTTA

GTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTT

GGCTTTGCTGGAAATGCCGTTCCAAAAACCC

ATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACG

ACTATTGTATACCTTACAATAGTGTAACTT

CTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTG

AACATGACTACCAGATTGGTGGTTATACTGAA

AAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTC

ACTTCAGACTATTACCAGCTGTACTCAACTCA

ATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAA

TAAAATTGTTGATGAGCCTGAAGAACATGTCC

AAATTCACACAATCGACGGTTCACCCGGAGTTGTTAATCCAGTAATGG

AACCAATTTATGATGAACCGACGACGACTACT

AGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCA

TTCGTTTCGGAAGAGACAGGTACGTTAATAGT

TAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACA

CTAGCCATCCTTACTGCGCTTCGATTGTGTG

CGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTA

CGTTTACTCTCGTGTTAAAAATCTGAATTCT

TCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGT

TTTTCTGTTTGGAACTTTAATTTTAGCCATG

GCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTT

GAACAATGGAACCTAGTAATAGGTTTCCTATT

CCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGG

TTTTTGTATATAATTAAGTTAATTTTCCTCT

GGCTGTTATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTA

CAGAATAAATTGGATCACCGGTGGAATTGCT

ATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATT

GCTTCTTTCAGACTGTTTGCGCGTACGCGTTC

CATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAACGTGCCACT

CCATGGCACTATTCTGACCAGACCGCTTCTAG

AAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTA

TTGCTGGACACCATCTAGGACGCTGTGACATC

AAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTC

TTATTACAAATTGGGAGCTTCGCAGCGTGTAGC

AGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTA

TAAATTAAACACAGACCATTCCAGTAGCAGTG

ACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTC

GTTGACTTTCAGGTTACTATAGCAGAGATATT

ACTAATTATTATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTAC

ATCATAAACCTCATAATTAAAAATTTATCTA

AGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAA

TGGAGATTGATTAAACGAACATGAAAATTATT

CTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACC

AAGAGTGTGTTAGAGGTACAACAGTACTTTT

AAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCA

TCCTCTAGCTGATAACAAATTTGCACTGACTT

GCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACG

TCTATCAGTTACGTGCCAGATCAGTTTCACCT

AAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAAT

TTTTCTTATTGTTGCGGCAATAGTGTTTATAAC

ACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATT

AATTGACTTCTATTTGTGCTTTTTAGCCTTTCT

GCTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAAC

TGCAAGATCATAATGAAACTTGTCACGCCT

AAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAG

CTGCATTTCACCAAGAATGTAGTTTACAGTCA

TGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACT

TCTATTCTAAATGGTATATTAGAGTAGGAGC

TAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTC

TAAATCACCCATTCAGTACATCGATATCGGTA

ATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGAAACCTAA

ATTGGGTAGTCTTGTAGTGCGTTGTTCGTTC

TATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCA

TCTAAACGAACAAACAAACTAAAATGTCTGA

TAATGGACCCCAAAATCAGCGAAATGCACCCCGCATTACGTTTGGTG

GACCCTCAGATTCAACTGGCAGTAACCAGAATG

GAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTT

ACCCAATAATACTGCGTCTTGGTTCACCGCTCTC

ACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGT

TCCAATTAACACCAATAGCAGTCGAGATGACCA

AATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACG

GTAAAATGAAAGATCTCAGTCCAAGATGGTATT

TCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTA

ACAAAGACGGCATCATATGGGTTGCAACTGAG

GGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGC

TAACAATGCTGCAATCGTGCTACAACTTCCTCA

AGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGC

GGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTA

GTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCTCTAAACGAACT

TCTCCTGCTAGAATGGCTGGCAATGGCGGTGAT

GCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAG

CAAAATGTCTGGTAAAGGCCAACAACAACAAGG

CCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTC

GGCAAAAACGTACTGCCACTAAAGCATACAATG

TAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAA

TTTTGGGGACCAGGAACTAATCAGACAAGGAACT

GATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCA

GCGTTCTTCGGAATGTCGCGCATTGGCATGGA

AGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAAT

TGGATGACAAAGATCCAAATTTCAAAGATCAAG

TCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAA

CAGAGCCTAAAAAGGACAAAAAGAAGAAGGCT

GATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTG

TGACTCTTCTTCCTGCTGCAGATTTGGATGATTT

CTCCAAACAATTGCAACAATCCATGAGCAGTGCTGACTCAACTCAGG

CCTAAACTCATGCAGACCACACAAGGCAGATGG

GCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTG

TGCAGAATGAATTCTCGTAACTACATAGCA

CAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTG

TGTAACATTAGGGAGGACTTGAAAGAGCCAC

CACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAA

CAATGCTAGGGAGAGCTGCCTATATGGAAGAGC

CCTAATGTGTAAAATTAATTTTAGTAGTGCTAACCCCATGTGATTTTAA

TAGCTTCTTA

SEQ ID NO:21

QQX12069.1 surface glycoprotein from genomic accession MW520923

MFVFLVLLPLVSSQCVNFTNRTQLPSAYTNSFTRGVYYPDKVFRSSVLHS

TQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNI

IRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNYPFLGVYYHKNN

KSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLSEFVFKNI

DGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYL

TPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSE

TKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFAS

VYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYAD

SFVIRGDEVRQIAPGQTGTIADYNYKLPDDFTGCVIAWNSNNLDSKVGG

NYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVKGFNCYFPLQSYGF

QPTYGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNG

LTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVS

VITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTGSNVFQT

RAGCLIGAEYVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYT

MSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDST

ECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDF

GGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAAR

DLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIP

FAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALG

KLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDR

LITGRLQSLQTYVTQQLIRAAEIRASANLAAIKMSECVLGQSKRVDFCG

KGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPRE

GVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPL

QPELDSFKEELDKYFKNHTSPDVDLGDISGINASFVNIQKEIDRLNEVAK

NLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSC

CSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT

SEQ ID NO:22

SARS-CoV-2 human/UK/MIG 457/2020, EVAg Ref-SKU 004V-04032, complete genome, coronavirus 2 isolate of Severe acute respiratory syndrome. <xnotran> B1.1.7 ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTTGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCTGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTATTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAATCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGATAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTTACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGTTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTACAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCARTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCTGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCATCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACCTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTT </xnotran>

CAATTCAG

TGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTT

GTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTT

ATGATAATAGGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTA

AAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAA

CAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTG

CTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGT

AGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACA

GGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGC

TCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAA

AGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTT

GCAATTTAC

AAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAA

ATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTAC

ATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAA

ACTGAAGGTTTATGTGTTGACATACCTGGCATACCTAAGGACATGACC

TATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTA

ATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATG

TACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAG

AAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTG

TTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATAC

AGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAA

ACACCTCATA

CCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATT

GTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTA

TTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTG

TGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCC

ACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTA

TTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATG

GGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGT

CCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTG

TCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGA

ATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAA

GGTTCAAC

ACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTC

ACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATG

TAGGATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATA

AAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCAC

AGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCT

AATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACT

TGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCC

ACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTAC

CATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAG

TAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAAC

ACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTA

CAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGC

TTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTA

CAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGG

GACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATA

ACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAA

ATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGC

GCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGT

GTGGATATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCT

CCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCA

AGAAACCAACTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGAT

GGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGT

GTTCTTATTACAGAAGGTAGTGTTAAAGGTTTACAACCATCTGTAGGT

CCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGT

AAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACA

ATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAA

ACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGA

ATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTT

TATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTG

GACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTA

TTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAA

CAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGA

TTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTT

GTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGTGTAA

AGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGC

GTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAAT

GCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATT

ACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCA

ATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATAC

ATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTT

TAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTA

ATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAA

CTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGA

CCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTT

TTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAG

GTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTT

ATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATG

TGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGG

CAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACAT

ATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTT

GACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTT

TAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAG

GTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATG

TTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGC

CACTAGTCTCTAGTCAGTGTGTTAATCTTACAACCAGAACTCAATTAC

CCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAA

AGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCT

TTCTTTTCCAATGTTACTTGGTTCCATGCTATCTCTGGGACCAATGGTA

CTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTT

TGCTTCCACTGAGAAGTC

TAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGAC

CCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTC

TGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTGTTTACCACAAAA

ACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCG

AATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTG

AAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAG

AATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTT

AGTGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGA

TTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTA

CATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCT

GGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTAT

TAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCAC

TTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTA

GAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGA

ATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGGTGAA

GTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGAAG

AGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTCCGCAT

CATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGA

TCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTGAT

GAAGTCAGACAAATCGCTCCAGGGCAAACTGGAAAGATTGCTGATTA

TAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAAT

TCTAACAATCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTATA

GATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAA

CTGAAATCTATCAGGCCGGTAGCACACCTTGTAATGGTGTTGAAGGTT

TTAATTGTTACTTTCCTTTACAATCATATGGTTTCCAACCCACTTATGGT

GTTGGTTACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTA

CATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTT

AAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGG

TGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGG

CAGAGACATTGATGACACTACTGATGCTGTCCGTGATCCACAGACAC

TTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTAT

AACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGG

GTGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTA

CTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACG

TGCAGGCTGTTTAATAGGGGCTGAACATGTCAACAACTCATATGAGTG

TGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGAC

TAATTCTCATCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGC

CTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAA

CTCTATTGCCATACCCATAAATTTTACTATTAGTGTTACCACAGAAATT

CTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATT

TGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGT

TTTTGTACACAATTAAACCGTGCTTTAACTGGAATAGCTGTTGAACAA

GACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACA

AAACACCACCAATTAAAGATTTTGGTGGTTTTAATTTTTCACAAATATT

ACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACT

TTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGG

TGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAA

GTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGAT

TGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTG

GACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAAT

GGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAG

AACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATT

CAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGA

TGTGGTCAACCAAAATGCACAAGCTTTAAACACGCTTGTTAAACAAC

TTAGCTCCAATTTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTGC

ACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCA

CAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTA

GAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGT

CAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAG

GGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCT

TCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACT

GCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGT

GTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTT

TATGAACCACAAATCATTACTACACACAACACATTTGTGTCTGGTAAC

TGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTG

CAACCTGAATTAGACTCATTCAAGGAGGAGTTAGATAAATATTTTAAG

AATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATG

CTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTT

GCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAG

TATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAG

CTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGAC

CAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTG

CAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAAT

TACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACA

ATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCC

TTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACT

CCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAG

AGCGCTTCCAAAATCATAACCCTCAAAAAGAGATGGCAACTAGCACT

CTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAAC

AGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTT

TCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTA

AGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAA

CCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTT

ACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTAC

TTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGAT

TGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTG

TATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCA

ATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAA

TAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCG

ACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATG

AACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAG

TACGAACTTATGTACTCATTCGTTTCGGAAGAGACAGGTACGTTAATA

GTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTAC

ACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATT

GTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTA

AAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACT

AAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAG

ATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAAC

AATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCT

ACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTA

ATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTTGTGCTTG

CTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAA

TGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTT

CAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTCAATCCAGAAAC

TAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACC

GCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGAC

ATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACC

TGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACA

AATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCA

T

ACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCA

GTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATG

TTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTAT

TATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAAC

CTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTC

AATTAGATGAAGAGCAACCAATGGAGATTGATTAAACGAACATGAAA

ATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATC

ACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCT

TGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCT

GATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTT

GTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTT

CACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCT

CCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCA

CACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTA

TTTGTGCTTTTTAGCCTTTCTGCTATTCCTTGTTTTAATTATGCTTATTAT

CTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGC

CTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGT

AGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTTAACATCA

ACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGG

TATATTAGAGTAGGAGCTATAAAATCAGCACCTTTAATTGAATTGTGCG

TGGATGAGGCTGGTTCTAAATCACCCATTCAGTGCATCGATATCGGTA

ATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAA

ATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGA

GTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACT

AAATGTCTCTAAATGGACCCCAAAATCAGCGAAATGCACCCCGCATT

ACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGA

ACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCC

AATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAA

GACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAG

CAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAA

TTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTAT

TTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCT

AACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATAC

ACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAA

TCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTAC

GCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATC

ACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAAAC

GAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTG

CTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTTT

GGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTG

CTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTA

AAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAA

ACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTG

ATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAG

CGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGA

ACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCC

AAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATA

CAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAG

GCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAA

CTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAAT

TGCAACAATCCATGAGCAGTGCTGACTCAACTCAGGCCTAAACTCAT

GCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCG

TTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACA

TAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAAT

CAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCAC

CGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGG

GAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGT

AGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGNNNNNN

NNNNNNNNNNNNNNNNNNNNNNNNNNNNN

SEQ ID NO:23

<xnotran> > MIG457_ gp02 , UK _ MIG457MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAISGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTYGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIDDTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSHRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPINFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILARLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTHNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT </xnotran>

SEQ ID NO:24

The SARS-CoV-2/human/USA/NMDOH-2021013232/2021 isolate of severe acute respiratory syndrome coronavirus 2 with > MW493681.1, whole genome. [ Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ], california B.1.427 lineage

AAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTT

GTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTC

GGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTG

TCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTAC

GGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTTGTCC

GGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAAC

GAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGA

CGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAG

AGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTT

GAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAA

ACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCT

GGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACAC

TTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCA

AGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTT

ACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACT

GATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAG

TGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACA

CTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTG

AGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTT

TGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCT

GCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAA

AAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAA

ATTT

GACATCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCA

TAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGC

TTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAAT

GCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTG

AAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTT

GTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTAC

TTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATT

CAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTG

GCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAG

GCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGG

TTCCACGTG

CTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTT

CCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAA

GTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCC

ATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTG

TGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTG

GTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAAT

ATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCA

GAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACT

GCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTA

GATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCA

CATCTGATTT

GGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGT

TCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGA

AAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAG

GTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAA

CCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAG

GAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTT

TTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAA

GCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTAC

AGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCT

AAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCA

CAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAA

CCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGT

ACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACA

GAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACC

TTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGA

CACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTG

AACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCT

ATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTG

GCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACA

CCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTAT

TTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTT

TTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAA

GAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTAC

CAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCT

GAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAA

CTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATT

CAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACC

AGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTT

ACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAA

AAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTA

AACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAAT

GCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTT

AAAGTGGGTGGTAGTTGT

GTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGC

CCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTAT

GAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCT

GGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATA

CTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGA

CAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTG

AACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATA

ACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGA

AAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACT

AAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATC

TTCATCCAGATT

CTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATG

CTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTG

TGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAATGCTAGCGA

AAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCG

GGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCT

TAAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTATTATCTCTAAT

GAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAAT

GCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGG

AAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTA

AAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACA

CCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAA

ATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAA

ATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTA

CAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCT

TACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTC

ACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACA

ACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACT

AGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGAC

AATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTG

TTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACAT

GTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGC

TGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATT

TTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTAC

TACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTA

AATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCT

ATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACA

CTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCT

TATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATC

TTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAA

ACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGA

GTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCT

TAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACA

ATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTAC

AAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACC

ACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGA

GTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAA

GAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAA

TACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACA

ACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACA

GAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTAT

TTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAAC

GCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTG

ATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGC

TTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGA

TTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACA

TAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTAT

AAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGT

TGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGG

GAATGGATAATCTTGTCTGCGAAGATCTAAAACCAGTCTCTGAAGAA

GTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGT

GAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATA

ATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCT

GCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTAT

CTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTG

TTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTT

AACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAAC

CGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATT

GTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCC

GACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCT

AGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATA

AATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAAT

CTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCT

TCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTC

ACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTA

GTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAAT

TACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCA

GAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTG

GATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTT

TATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGG

CCCCGATTTCAGCTATGGTTAGAATGTACATCTTCT

TTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGG

TTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAAC

AAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTA

TGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAA

TTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGAT

GAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCC

TACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGG

TTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAG

ACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAA

CACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCA

AAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAG

CTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATG

TTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTA

ATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACAC

TAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGAC

AATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATT

CAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATC

AATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCAC

CTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTAT

TGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACA

ACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAAC

AACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCT

TTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACA

ACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAG

CAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCT

ATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAG

TGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACAT

AGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACAC

ATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCC

ATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTG

GTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATT

TCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCAT

CAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGG

CTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCAT

ATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTT

ACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTT

CCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGAT

TCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGT

TTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGA

TCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTACTA

ATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGC

ATCTATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTTGCC

TACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAG

TTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTA

ACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTA

CTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGT

GGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTA

TATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTACTAATTACC

TAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAG

AAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGT

TGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGC

TCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGC

TACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTC

AGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATC

ACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCT

GGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTAC

ACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGT

GATCTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACT

CATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAA

CTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAG

GTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATT

CAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCA

TCTGGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTATTAAGGGTT

CATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGA

CTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTT

CATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGAC

AGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAA

TGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTT

TCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATG

AAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGA

CCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCAT

TAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTA

GTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATG

CTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTA

CACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGT

CCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTT

TTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTT

TGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTT

GCCACTG

TAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATT

ATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAA

AAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGAC

AGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTA

TGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGA

TCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTAC

TCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAAAGGTATTGTTTTTA

TGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCA

GTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACT

TTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTG

TTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACA

GGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACA

TTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTG

TACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCT

CAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTC

AATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTG

AAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGC

AGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAAC

AGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCA

TATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCT

AATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAAT

GTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTG

GAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAG

ATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGC

TTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTAT

CAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTAC

AACAGCAGCCAAATTAATGGTTGTCATACCAGACTATAACACATATAA

AAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGA

AATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGA

AATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACA

GCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGT

CCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACT

GCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGG

AGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATG

GGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACT

GGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAG

TGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTAT

GGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGC

AACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGC

TGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACA

ACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGG

TCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCT

TTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATC

CAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATAC

CTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAG

TCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATC

AACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAA

ACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAG

GCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATA

AAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCC

AAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTA

AGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATT

TACTTAAAGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTA

GAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTA

AATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAG

GTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTG

ATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACC

CAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAG

CTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTA

TTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTA

TGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGT

TGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGG

CTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACA

TTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAA

CTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATT

GTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTA

ATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGT

GAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATA

CCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACA

TAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCT

GCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGT

GCTTTTCAGTA

GCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAAT

TTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAG

GAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGT

AATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAA

TGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTA

CTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTC

AACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAG

GCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTT

TCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCT

TAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGT

CTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTG

AAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAG

CAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGA

TGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAG

AGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCG

CAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGC

TAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTC

ACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTG

CTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGT

TAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTC

CGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGAT

GTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACAT

TTCTCAATGATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCA

CTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAG

TTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGAC

TGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATAC

AATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGA

TCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAA

AACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGA

TGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTT

CATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGA

CACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAA

GGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAG

TCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCAT

TAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTG

TTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAAT

CCGTATGTTTGCAATGCTCTAGGTTGTGATGTCACAGATGTGACTCAA

CTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCA

TTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAA

TACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACA

TGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACT

GAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGG

AGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGT

CTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCA

CCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAAC

AGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGG

TGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGG

TGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCT

ACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCA

ACACTCAATATCTCATATGAGTTTTCTAGCAATGTTGCAAATTATCAAA

AGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACT

GGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTC

GCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGA

GAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCT

GCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACA

TTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACA

GCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATT

TGAGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTGTACATTG

GCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGC

ACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACT

ATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAA

ATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCA

CATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTT

ATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTG

GTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTT

ATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGA

CTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTAT

GTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAAC

AGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATA

ATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAA

ATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGG

ACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACA

GGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTT

TATGTGTTGACATACCTGGCATACCTAAGGACATGACCTATAGAAGAC

TCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCC

TAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATG

GATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTG

GTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGT

TGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCC

AGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATA

CCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATT

GTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTA

TTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTG

TGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCC

ACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTA

TTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATG

GGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGT

CCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTG

TCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGA

ATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAA

GGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCC

AGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCA

AGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACA

AAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGA

CAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGA

TATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTA

ACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAAC

ATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAA

AACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGG

AAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTAC

GTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGC

TAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCT

GGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGG

AACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTT

GTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTC

TATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGA

ATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCT

TTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCA

ATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACA

AAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGAC

TGACATAGCCAAGAAACCAACTGAAACGATTTGTGCACCACTCACTG

TCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATG

CCCGTAATGGTGTTCTTATTACAGAAGGTAGTGTTAAAGGTTTACAAC

CATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTG

GAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGT

GTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTA

CAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTA

GCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTC

GAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTAC

ATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATT

AGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAAC

AGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTT

ATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTA

GTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTA

TGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTAC

AATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACA

AAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGT

GATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATAT

ACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATA

ATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCAC

CAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTT

GTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGA

TTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTAT

TAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATG

ACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAA

AGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTT

GGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAG

CCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGG

ATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCAT

GCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTC

TTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGT

ACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTAT

CTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTG

TTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTT

TTCTTGTTTTATTGCCACTAGTCTCTATTCAGTGTGTTAATCTTACAAC

CAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGT

TTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCA

GGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATA

CATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTA

CCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAA

TAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCC

TACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTT

CAATTTTGTAATGATCCATTTTTGGGTGTTTATTACCACAAAAACAAC

AAAAGTTGTATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAAT

TGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGA

AAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATT

GATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGTGC

GTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGC

CAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAG

AAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGC

TGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAA

TATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGAC

CCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAA

AGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTAT

TGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGGTGAAGTTTTT

AACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAAT

CAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTCCGCATCATTTT

CCACTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTG

CTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTGATGAAGTC

AGACAAATCGCTCCAGGGCAAACTGGAAAGATTGCTGATTA

TAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAAT

TCTAACAATCTTGATTCTAAGGTTGGTGGTAATTATAATTACCGGTATA

GATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAA

CTGAAATCTATCAGGCCGGTAGCACACCTTGTAATGGTGTTGAAGGTT

TTAATTGTTACTTTCCTTTACAATCATATGGTTTCCAACCCACTAATGG

TGTTGGTTACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCT

ACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGT

TAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAG

GTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTG

GCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACA

CTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTA

TAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGG

GTGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTA

CTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACG

TGCAGGCTGTTTAATAGGGGCTGAACATGTCAACAACTCATATGAGTG

TGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGAC

TAATTCTCCTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGC

CTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAA

CTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATT

CTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATT

TGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGT

TTTTGTACACAATTAAACCGTGCTTTAACTGGAATAGCTGTTGAACAA

GACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACA

AAACACCACCAATTAAAGATTTTGGTGGTTTTAATTTTTCACAAATATT

ACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACT

TTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGG

TGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAA

GTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGAT

TGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTG

GACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAAT

GGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAG

AACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATT

CAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGA

TGTGGTCAACCAAAATGCACAAGCTTTAAACACGCTTGTTAAACAAC

TTAGCTCCAATTTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTC

ACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCA

CAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTA

GAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGT

CAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAG

GGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCT

TCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACT

GCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGT

GTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTT

TATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAAC

TGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTG

CAACCTGAATTAGACTCATTCAAGGAGGAGTTAGATAAATATTTTAAG

AATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATG

CTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTT

GCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAG

TATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAG

CTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGAC

CAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTG

CAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAAT

TACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACA

ATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCC

TTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACT

CCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAT

AGCGCTTCCAAAATCATAACCCTCAAAAAGAGATGGCAACTAGCACT

CTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAAC

AGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTT

TCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTA

AGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAA

CCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTT

ACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTAC

TTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGAT

TGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTG

TATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCA

ATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAA

TAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCG

ACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTAT

GATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGA

TGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGACAGGTACGTT

AATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTA

GTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGC

AATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTC

GTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAA

CGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCA

TGGTAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCC

TTGAACAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTG

TCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATT

AAGTTAATTTTTCTCTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTTG

TGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTA

TCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTG

CTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTCAATC

CAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGA

CCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTT

CGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATC

AAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTC

TTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTT

TGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGA

CCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGAC

AACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATT

ACTAATTATTATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTAC

ATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATA

AATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTGATTAAACGA

ACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTG

AGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAA

AAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATC

CTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTG

CTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCA

GATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAA

CTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACAC

TTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAAT

TGACTTCTATTTGTGCTTTTTAGCCTTTCTGCTATTCCTTGTTTTAATTA

TGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAAC

TTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCAT

CACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTAC

TCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTAT

TCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATT

GAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATC

GATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCA

GGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGA

CTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACG

AACAAACTATAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCA

CCCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCA

GAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAA

GGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACAT

GGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAA

CACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTA

CCAGACGAATTCGTGGTGGT

GACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTA

GGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACG

GCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGAT

CACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAA

CTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGA

GCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGC

AACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAGGGGAATTTCTCC

TGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCT

GCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCC

AACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGC

TTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATG

TAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGG

AAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAAC

ATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCG

GAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTG

ACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAA

AGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATT

TCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAA

ACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTC

TTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAAT

CCATGAGCAGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCAC

ACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATAT

ATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAG

TAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTA

ACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCAC

GCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCC

TATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCSEQ ID NO:25

QQV21856.1: S surface protein

MFVFLVLLPLVSIQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHS

TQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNI

IRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNN

KSCMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNID

GYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLT

PGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSET

KCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASV

YAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADS

FVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGG

NYNYRYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGF

QPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNG

LTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVS

VITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTGSNVFQT

RAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYT

MSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDST

ECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDF

GGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAAR

DLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIP

FAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALG

KLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDR

LITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCG

KGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPRE

GVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPL

QPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAK

NLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSC

CSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT

SEQ ID NO:26

(> MW306426.1 Severe acute respiratory syndrome coronavirus 2 isolate SARS-CoV-2/human/USA/CA-CZB-12872/2020, whole genome. [ Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ]. California B.1.429 lineage

ACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGT

GTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTA

ATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTC

TGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACA

TCTAGGTTTTGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTG

TCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTT

TTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGA

GGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTG

GCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCC

TATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCAT

GTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCG

TAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACC

AGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAG

CTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCG

ACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAAC

ACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAA

CGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGA

TGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAA

AGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAG

GGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACAC

GGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTA

AATTGGCAAAGAAATTTGACATCTTCAATGGGGAATGTCCAAATTTTG

TATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAA

AGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAG

TTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGA

AGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTA

AAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGT

GCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATT

GTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCC

GAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGT

CGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATA

ACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTA

ACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAAC

CTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGT

GACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTG

CTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAA

GCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAA

GGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAAT

ACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACG

ATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGT

TTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTC

ACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAAC

AATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACT

TCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAA

CCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTT

TCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTG

TGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGG

AGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGT

GTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTT

AGGTGAAACATTTGTTACGCACTCAAAGGGATTGTACAGAAAGTGTG

TTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCA

AAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTT

AACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAAC

AACCTACTAGTGAAGCTGTTGAAGCTCCACTGGTTGGTACACCAGTT

TGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTA

CTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACT

CAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGA

TAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGAT

GAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTT

GAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGC

TGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGG

CATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAG

TCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTC

CAGA

TGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCA

TCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCT

TTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCA

AGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAAC

AAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTT

GAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGAC

TATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTA

TACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACC

AACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAG

GTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTT

GAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGT

AGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTT

GTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAG

TGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTA

TCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTG

TAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCT

CTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGC

AAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCA

TTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGA

TAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAG

AAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATG

GCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCA

CTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAG

AGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCA

CTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAAT

TATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAG

GAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCCTTTTACATTCT

ACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTC

TTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAAT

TAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGC

GTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTG

CTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCA

ACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCT

ATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGAT

CTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTA

CAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAAC

ATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTA

TTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGA

TAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGT

GAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAA

GTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCA

CACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTC

CAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTC

ACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGT

GTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGT

AGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACA

AGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTT

GCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCA

CCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGC

TAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGA

GTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAA

TTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTG

GACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATG

GGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGT

ACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACC

TTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGG

TACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCA

CTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCT

TTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCT

ACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAA

TTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTAT

TATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTA

CCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTA

TGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATA

AGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAA

ATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAA

GAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAA

TGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTG

TCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACT

GAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATC

TAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAA

GACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACAT

TATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGG

CCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATT

AAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCT

ACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTA

ATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACAT

AGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTC

TTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTA

GAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGA

GTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACC

TAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTG

TTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAAT

GTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTA

TTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATA

CCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTT

CTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAAC

TGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACT

AGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCA

GCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATA

ATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACA

TCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTA

GACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGA

GCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTC

CTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAA

TTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATT

AGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAAT

AAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAA

GAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTA

TGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGC

TAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGT

AAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTAC

AGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGT

CTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTT

ACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCA

AAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCC

TTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTG

TTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGT

CACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATAT

GCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTG

CTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAA

GTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTC

TGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACT

TACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTG

TAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGT

TGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTAT

TTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTT

TCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGT

GACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTG

ACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTT

GCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTG

CCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTG

CATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAATATCTGTTACACAC

CATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTT

TGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTAC

CATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAG

TTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAA

TTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTT

GATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGG

TGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTAC

AGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTA

CTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATC

AGCATCTATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTT

GCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCAT

GTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTG

TTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACT

TGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATT

CAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTG

CTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAAT

TACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTG

AAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAA

AGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTT

AGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACT

AGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGA

CTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTC

TATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCC

ATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAAC

TACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACA

TGTGATCTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTT

ACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTT

CAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTT

AAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGC

ATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCA

CCATCTGGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTATTAAGG

GTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTA

TGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGG

AGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGT

TGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACA

GTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGG

TGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGG

CTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATAC

TAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTG

CTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATAT

TGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAG

ACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCA

AGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAG

TTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAA

TGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAA

TGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACC

TTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTT

GGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTC

TGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTT

ACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAG

AGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTAT

GGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTG

TTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCA

GAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACT

GGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTT

TTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGA

CTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGAT

ATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCT

TCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCA

AAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCA

GTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCT

AAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCT

AAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTT

TTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGA

AATGCTGGACAACAGGGCAACCTTACAAGCTATAGCTTCAGAGTTTA

GTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGA

GCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAA

GAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCAT

GCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGT

ATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCT

ATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCA

CTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAAC

ATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGAC

TATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCAT

CAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATT

GTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGG

CCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAG

AATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCC

GGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTAC

AACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTA

CAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTAC

TGTCTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACC

TAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAA

CCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCT

ACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATC

TTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTA

GCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACA

CACACTGGTACTGGTCAGGCAATAACAGTTACA

CCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGT

CTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGT

GACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGAC

CCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATG

TGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTT

CAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGT

GCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGT

ATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAA

ATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATG

ACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAA

CTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGC

TGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGT

ACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCT

CGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAA

AGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAA

AAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATAC

GCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACA

ATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTA

GATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATAC

AAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATT

GTTAATGCCTATATTAACC

TTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAAC

AAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGA

GAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATA

CCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTG

TGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTT

GGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTT

TCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGAT

GTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATG

CTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAA

ACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTT

TCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGC

TGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAAC

ACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTA

CTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTT

GTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGT

ATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGT

TTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGA

GTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCA

TCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAA

TAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAA

TAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGG

AGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACA

ACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGG

GTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAAT

TATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTT

GTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAG

TGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAAC

CTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATT

TGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGT

AACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTAT

GAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGA

GTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTCTCTGAC

GATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTG

GCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTT

TTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGG

ACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGA

TGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGC

CGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATT

GAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATC

CTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAG

AAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGT

TATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTAT

GAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGT

GTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGT

AGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACAT

CACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGG

TTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTA

TTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAAT

GGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATG

TTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTG

ATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAG

CAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGT

ATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCA

TGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTT

ACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTA

CACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTAC

AACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACAT

ACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTAT

GTTAGAATTACTGGCTTATACCCAACACTCAATATCTCATATGAGTTTT

CTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTA

CACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCC

TAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCA

TGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATA

GATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTT

GATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACT

GTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAA

ATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTAC

GTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCAC

CACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATT

CAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAA

CTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGG

TTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCT

TTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAAT

TAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACC

CTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATG

CTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCAT

CACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAA

CAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAG

CAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACA

AGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTT

TACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAA

TCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGAC

ACTAAATTCAAAACTGAAGGTTTATGTGTTGACATACCTGGCATACCT

AAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATG

AATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAA

GCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGT

CATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGT

TTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATA

CACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTG

GAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTT

GGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTA

AAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTG

AGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCT

GTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACA

CTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCG

TTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGC

AACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTT

GTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTA

AGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGA

AGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCT

GCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCT

AAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTAT

GATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTC

TATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTAT

TTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAG

ATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGG

TGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGA

TAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCT

GACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGA

TTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGT

GGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGAT

GCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAA

CAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGT

TTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGA

CAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACA

AAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTA

CCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCA

GTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCT

AATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCT

ACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAACTGAA

ACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGT

CAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAA

GGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAG

TCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCA

ATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTT

ACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAA

ATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGT

ATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAG

TCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACG

TTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGT

ACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAG

TGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAAT

AAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTAT

TGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTA

GAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGG

TGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAA

GTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCAT

AATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACAC

ATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCT

GGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTG

GTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGT

CTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATAC

AGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACT

AAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTA

CATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGC

TATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATG

GGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCA

TCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCG

AACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAA

TACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAA

TTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGT

CAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAAT

TAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAA

CTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAT

TCAGTGTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACAC

TAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCC

TCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATG

TTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGA

GGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTC

CACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTT

AGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTT

GTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTG

TTTATTACCACAAAAACAACAAAAGTTGTATGGAAAGTGAGTTCAGA

GTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTT

TTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGG

GAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCA

CACGCCTATTAATTTAGTGCGTGATCTCCCTCAGGGTTTTTCGGCTTTA

GAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAA

ACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTT

CAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAAC

CTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGC

TGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGA

AATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAG

TCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTG

CCCTTTTGGTGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCT

TGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTA

TATAATTCCGCATCATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCTA

CTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTA

ATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGGGCAAACTGGAA

AGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGC

GTTATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAATT

ATAATTACCGGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGA

GAGAGATATTTCAACTGAAATCTATCAGGCCGGTAGCACACCTTGTAA

TGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACAATCATATGGTTTC

CAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTAGTAGTACTT

TCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAG

TCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGT

TTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCC

TTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCG

TGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGG

TGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGC

TGTTCTTTATCAGGGTGTTAACTGCACAGAAGTCCCTGTTGCTATTCA

TGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAAT

GTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAACATGTCAA

CAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAG

TTATCAGACTCAGACTAATTCTCCTCGGCGGGCACGTAGTGTAGCTAG

TCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGT

TGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTG

TTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATT

GTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGT

TGCAATATGGCAGTTTTTGTACACAATTAAACCGTGCTTTAACTGGAA

TAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGT

CAAACAAATTTACAAAACACCACCAATTAAAGATTTTGGTGGTTTTAA

TTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATT

TATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTT

CATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCT

CATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCT

CACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTAC

AATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACC

ATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAG

AATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGC

GCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTT

GGAAAACTTCAAGATGTGGTCAACCAAAATGCACAAGCTTTAAACAC

GCTTGTTAAACAACTTAGCTCCAATTTTGGTGCAATTTCAAGTGTTTT

AAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAAT

TGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGA

CTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTG

CTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTT

GATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCA

CCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAA

AAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACA

CTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGT

AACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACA

CATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACA

CAGTTTATGATCCTTTGCAACCTGAATTAGACTCATTCAAGGAGGAGT

TAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGA

CATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGA

CCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCT

CCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACAT

TTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATT

ATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGT

TCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGT

GCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTG

TTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGA

AATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGAT

ACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGC

ACTTCTTGCTGTTTTTCATAGCGCTTCCAAAATCATAACCCTCAAAAA

GAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACT

TGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGT

TGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTC

TACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGG

CTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAAC

TATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAA

TAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAG

TCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATG

GGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTC

AGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTGT

TGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGA

AGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAA

TCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGT

GCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGT

TTCGGAAGAGACAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCT

TGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTT

CGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAA

CCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAG

TTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGT

TTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGT

TGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAATAGGTT

TCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAG

GAATAGGTTTTTGTATATAATTAAGTTAATTTTTCTCTGGCTGTTATGGC

CAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTG

GATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGAT

GTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCG

TTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAACGTGCC

ACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGT

AATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCA

TCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTG

CTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTG

TAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGC

AACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCT

TTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCA

GGTTACTATAGCAGAGATATTACTAATTATTATGAGGACTTTTAAAGTT

TCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATC

TAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACC

AATGGAGATTGATTAAACGAACATGAAAATTATTCTTTTCTTGGCACT

GATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAG

AGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACG

AGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGA

CTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAAC

ACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCA

GACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTG

CGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACA

GAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTT

TCTGCTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTG

AACTGCAAGATCATAATGAAACTTGTCACGCCTAAACTAACATGAAAT

TTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAG

AATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGA

CCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCT

AGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCT

AAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTT

TACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGT

GCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTT

GTTTTAGATTTCATCTAAACGAACAAACTATAATGTCTGATAATGGACC

CCAAAATCAGCGAAATGCACCCCGCATTACGTTTGGTGGACCCTCAG

ATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATC

AAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGT

TCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGA

GGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAAT

TGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTA

AAATGAAAGATCTCAGTCCAAGATGGT

ATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTG

CTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAAT

ACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGC

AATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCT

ACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTC

ATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTA

GGGGAATTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTC

TTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATG

TCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAAT

CTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACT

AAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACA

AACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACT

GATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCA

GCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGG

AACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATC

CAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCAT

ACAAAACATTTCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAA

GGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAA

ACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAA

TTGCAACAATCCATGAGCAGTGCTGACTCAACTCAGGCCTAAACTCA

TGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCC

GTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTAC

ATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAA

TCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCA

CCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGG

GAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGT

AGTGCTATCCCCATGTGATTTTAATAGC

SEQ ID NO:27

QPJ72086.1. S-protein surface glycoprotein

MFVFLVLLPLVSIQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHS

TQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNI

IRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNN

KSCMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNID

GYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLT

PGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSET

KCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASV

YAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADS

FVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGG

NYNYRYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGF

QPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNG

LTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVS

VITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTGSNVFQT

RAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYT

MSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDST

ECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDF

GGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAAR

DLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIP

FAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALG

KLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDR

LITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCG

KGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPRE

GVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPL

QPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAK

NLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSC

CSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT

SEQ ID NO:28

<xnotran> > [ 2] ( No: QIA 98561) MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSSADSTQA </xnotran>

SEQ ID NO:29

<xnotran> > [ 2] ( No: QIA 98557) MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ. </xnotran>

Sequence listing

<110> Wal Newa Austria Limited liability company

<120> inactivated SARS-CoV-2 virus vaccine

<130> P6132WO00

<150> EP 20168324.0

<151> 2020-04-06

<150> EP 20202118.4

<151> 2020-10-15

<150> EP 20211853.5

<151> 2020-12-04

<150> EP 21154647.8

<151> 2021-02-01

<150> EP 21160913.6

<151> 2021-03-05

<150> US 21/20313

<151> 2021-03-01

<160> 29

<170> PatentIn version 3.5

<210> 1

<211> 29903

<212> DNA

<213> SARS-CoV2

<400> 1

attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct 60

gttctctaaa cgaactttaa aatctgtgtg gctgtcactc ggctgcatgc ttagtgcact 120

cacgcagtat aattaataac taattactgt cgttgacagg acacgagtaa ctcgtctatc 180

ttctgcaggc tgcttacggt ttcgtccgtg ttgcagccga tcatcagcac atctaggttt 240

cgtccgggtg tgaccgaaag gtaagatgga gagccttgtc cctggtttca acgagaaaac 300

acacgtccaa ctcagtttgc ctgttttaca ggttcgcgac gtgctcgtac gtggctttgg 360

agactccgtg gaggaggtct tatcagaggc acgtcaacat cttaaagatg gcacttgtgg 420

cttagtagaa gttgaaaaag gcgttttgcc tcaacttgaa cagccctatg tgttcatcaa 480

acgttcggat gctcgaactg cacctcatgg tcatgttatg gttgagctgg tagcagaact 540

cgaaggcatt cagtacggtc gtagtggtga gacacttggt gtccttgtcc ctcatgtggg 600

cgaaatacca gtggcttacc gcaaggttct tcttcgtaag aacggtaata aaggagctgg 660

tggccatagt tacggcgccg atctaaagtc atttgactta ggcgacgagc ttggcactga 720

tccttatgaa gattttcaag aaaactggaa cactaaacat agcagtggtg ttacccgtga 780

actcatgcgt gagcttaacg gaggggcata cactcgctat gtcgataaca acttctgtgg 840

ccctgatggc taccctcttg agtgcattaa agaccttcta gcacgtgctg gtaaagcttc 900

atgcactttg tccgaacaac tggactttat tgacactaag aggggtgtat actgctgccg 960

tgaacatgag catgaaattg cttggtacac ggaacgttct gaaaagagct atgaattgca 1020

gacacctttt gaaattaaat tggcaaagaa atttgacacc ttcaatgggg aatgtccaaa 1080

ttttgtattt cccttaaatt ccataatcaa gactattcaa ccaagggttg aaaagaaaaa 1140

gcttgatggc tttatgggta gaattcgatc tgtctatcca gttgcgtcac caaatgaatg 1200

caaccaaatg tgcctttcaa ctctcatgaa gtgtgatcat tgtggtgaaa cttcatggca 1260

gacgggcgat tttgttaaag ccacttgcga attttgtggc actgagaatt tgactaaaga 1320

aggtgccact acttgtggtt acttacccca aaatgctgtt gttaaaattt attgtccagc 1380

atgtcacaat tcagaagtag gacctgagca tagtcttgcc gaataccata atgaatctgg 1440

cttgaaaacc attcttcgta agggtggtcg cactattgcc tttggaggct gtgtgttctc 1500

ttatgttggt tgccataaca agtgtgccta ttgggttcca cgtgctagcg ctaacatagg 1560

ttgtaaccat acaggtgttg ttggagaagg ttccgaaggt cttaatgaca accttcttga 1620

aatactccaa aaagagaaag tcaacatcaa tattgttggt gactttaaac ttaatgaaga 1680

gatcgccatt attttggcat ctttttctgc ttccacaagt gcttttgtgg aaactgtgaa 1740

aggtttggat tataaagcat tcaaacaaat tgttgaatcc tgtggtaatt ttaaagttac 1800

aaaaggaaaa gctaaaaaag gtgcctggaa tattggtgaa cagaaatcaa tactgagtcc 1860

tctttatgca tttgcatcag aggctgctcg tgttgtacga tcaattttct cccgcactct 1920

tgaaactgct caaaattctg tgcgtgtttt acagaaggcc gctataacaa tactagatgg 1980

aatttcacag tattcactga gactcattga tgctatgatg ttcacatctg atttggctac 2040

taacaatcta gttgtaatgg cctacattac aggtggtgtt gttcagttga cttcgcagtg 2100

gctaactaac atctttggca ctgtttatga aaaactcaaa cccgtccttg attggcttga 2160

agagaagttt aaggaaggtg tagagtttct tagagacggt tgggaaattg ttaaatttat 2220

ctcaacctgt gcttgtgaaa ttgtcggtgg acaaattgtc acctgtgcaa aggaaattaa 2280

ggagagtgtt cagacattct ttaagcttgt aaataaattt ttggctttgt gtgctgactc 2340

tatcattatt ggtggagcta aacttaaagc cttgaattta ggtgaaacat ttgtcacgca 2400

ctcaaaggga ttgtacagaa agtgtgttaa atccagagaa gaaactggcc tactcatgcc 2460

tctaaaagcc ccaaaagaaa ttatcttctt agagggagaa acacttccca cagaagtgtt 2520

aacagaggaa gttgtcttga aaactggtga tttacaacca ttagaacaac ctactagtga 2580

agctgttgaa gctccattgg ttggtacacc agtttgtatt aacgggctta tgttgctcga 2640

aatcaaagac acagaaaagt actgtgccct tgcacctaat atgatggtaa caaacaatac 2700

cttcacactc aaaggcggtg caccaacaaa ggttactttt ggtgatgaca ctgtgataga 2760

agtgcaaggt tacaagagtg tgaatatcac ttttgaactt gatgaaagga ttgataaagt 2820

acttaatgag aagtgctctg cctatacagt tgaactcggt acagaagtaa atgagttcgc 2880

ctgtgttgtg gcagatgctg tcataaaaac tttgcaacca gtatctgaat tacttacacc 2940

actgggcatt gatttagatg agtggagtat ggctacatac tacttatttg atgagtctgg 3000

tgagtttaaa ttggcttcac atatgtattg ttctttctac cctccagatg aggatgaaga 3060

agaaggtgat tgtgaagaag aagagtttga gccatcaact caatatgagt atggtactga 3120

agatgattac caaggtaaac ctttggaatt tggtgccact tctgctgctc ttcaacctga 3180

agaagagcaa gaagaagatt ggttagatga tgatagtcaa caaactgttg gtcaacaaga 3240

cggcagtgag gacaatcaga caactactat tcaaacaatt gttgaggttc aacctcaatt 3300

agagatggaa cttacaccag ttgttcagac tattgaagtg aatagtttta gtggttattt 3360

aaaacttact gacaatgtat acattaaaaa tgcagacatt gtggaagaag ctaaaaaggt 3420

aaaaccaaca gtggttgtta atgcagccaa tgtttacctt aaacatggag gaggtgttgc 3480

aggagcctta aataaggcta ctaacaatgc catgcaagtt gaatctgatg attacatagc 3540

tactaatgga ccacttaaag tgggtggtag ttgtgtttta agcggacaca atcttgctaa 3600

acactgtctt catgttgtcg gcccaaatgt taacaaaggt gaagacattc aacttcttaa 3660

gagtgcttat gaaaatttta atcagcacga agttctactt gcaccattat tatcagctgg 3720

tatttttggt gctgacccta tacattcttt aagagtttgt gtagatactg ttcgcacaaa 3780

tgtctactta gctgtctttg ataaaaatct ctatgacaaa cttgtttcaa gctttttgga 3840

aatgaagagt gaaaagcaag ttgaacaaaa gatcgctgag attcctaaag aggaagttaa 3900

gccatttata actgaaagta aaccttcagt tgaacagaga aaacaagatg ataagaaaat 3960

caaagcttgt gttgaagaag ttacaacaac tctggaagaa actaagttcc tcacagaaaa 4020

cttgttactt tatattgaca ttaatggcaa tcttcatcca gattctgcca ctcttgttag 4080

tgacattgac atcactttct taaagaaaga tgctccatat atagtgggtg atgttgttca 4140

agagggtgtt ttaactgctg tggttatacc tactaaaaag gctggtggca ctactgaaat 4200

gctagcgaaa gctttgagaa aagtgccaac agacaattat ataaccactt acccgggtca 4260

gggtttaaat ggttacactg tagaggaggc aaagacagtg cttaaaaagt gtaaaagtgc 4320

cttttacatt ctaccatcta ttatctctaa tgagaagcaa gaaattcttg gaactgtttc 4380

ttggaatttg cgagaaatgc ttgcacatgc agaagaaaca cgcaaattaa tgcctgtctg 4440

tgtggaaact aaagccatag tttcaactat acagcgtaaa tataagggta ttaaaataca 4500

agagggtgtg gttgattatg gtgctagatt ttacttttac accagtaaaa caactgtagc 4560

gtcacttatc aacacactta acgatctaaa tgaaactctt gttacaatgc cacttggcta 4620

tgtaacacat ggcttaaatt tggaagaagc tgctcggtat atgagatctc tcaaagtgcc 4680

agctacagtt tctgtttctt cacctgatgc tgttacagcg tataatggtt atcttacttc 4740

ttcttctaaa acacctgaag aacattttat tgaaaccatc tcacttgctg gttcctataa 4800

agattggtcc tattctggac aatctacaca actaggtata gaatttctta agagaggtga 4860

taaaagtgta tattacacta gtaatcctac cacattccac ctagatggtg aagttatcac 4920

ctttgacaat cttaagacac ttctttcttt gagagaagtg aggactatta aggtgtttac 4980

aacagtagac aacattaacc tccacacgca agttgtggac atgtcaatga catatggaca 5040

acagtttggt ccaacttatt tggatggagc tgatgttact aaaataaaac ctcataattc 5100

acatgaaggt aaaacatttt atgttttacc taatgatgac actctacgtg ttgaggcttt 5160

tgagtactac cacacaactg atcctagttt tctgggtagg tacatgtcag cattaaatca 5220

cactaaaaag tggaaatacc cacaagttaa tggtttaact tctattaaat gggcagataa 5280

caactgttat cttgccactg cattgttaac actccaacaa atagagttga agtttaatcc 5340

acctgctcta caagatgctt attacagagc aagggctggt gaagctgcta acttttgtgc 5400

acttatctta gcctactgta ataagacagt aggtgagtta ggtgatgtta gagaaacaat 5460

gagttacttg tttcaacatg ccaatttaga ttcttgcaaa agagtcttga acgtggtgtg 5520

taaaacttgt ggacaacagc agacaaccct taagggtgta gaagctgtta tgtacatggg 5580

cacactttct tatgaacaat ttaagaaagg tgttcagata ccttgtacgt gtggtaaaca 5640

agctacaaaa tatctagtac aacaggagtc accttttgtt atgatgtcag caccacctgc 5700

tcagtatgaa cttaagcatg gtacatttac ttgtgctagt gagtacactg gtaattacca 5760

gtgtggtcac tataaacata taacttctaa agaaactttg tattgcatag acggtgcttt 5820

acttacaaag tcctcagaat acaaaggtcc tattacggat gttttctaca aagaaaacag 5880

ttacacaaca accataaaac cagttactta taaattggat ggtgttgttt gtacagaaat 5940

tgaccctaag ttggacaatt attataagaa agacaattct tatttcacag agcaaccaat 6000

tgatcttgta ccaaaccaac catatccaaa cgcaagcttc gataatttta agtttgtatg 6060

tgataatatc aaatttgctg atgatttaaa ccagttaact ggttataaga aacctgcttc 6120

aagagagctt aaagttacat ttttccctga cttaaatggt gatgtggtgg ctattgatta 6180

taaacactac acaccctctt ttaagaaagg agctaaattg ttacataaac ctattgtttg 6240

gcatgttaac aatgcaacta ataaagccac gtataaacca aatacctggt gtatacgttg 6300

tctttggagc acaaaaccag ttgaaacatc aaattcgttt gatgtactga agtcagagga 6360

cgcgcaggga atggataatc ttgcctgcga agatctaaaa ccagtctctg aagaagtagt 6420

ggaaaatcct accatacaga aagacgttct tgagtgtaat gtgaaaacta ccgaagttgt 6480

aggagacatt atacttaaac cagcaaataa tagtttaaaa attacagaag aggttggcca 6540

cacagatcta atggctgctt atgtagacaa ttctagtctt actattaaga aacctaatga 6600

attatctaga gtattaggtt tgaaaaccct tgctactcat ggtttagctg ctgttaatag 6660

tgtcccttgg gatactatag ctaattatgc taagcctttt cttaacaaag ttgttagtac 6720

aactactaac atagttacac ggtgtttaaa ccgtgtttgt actaattata tgccttattt 6780

ctttacttta ttgctacaat tgtgtacttt tactagaagt acaaattcta gaattaaagc 6840

atctatgccg actactatag caaagaatac tgttaagagt gtcggtaaat tttgtctaga 6900

ggcttcattt aattatttga agtcacctaa tttttctaaa ctgataaata ttataatttg 6960

gtttttacta ttaagtgttt gcctaggttc tttaatctac tcaaccgctg ctttaggtgt 7020

tttaatgtct aatttaggca tgccttctta ctgtactggt tacagagaag gctatttgaa 7080

ctctactaat gtcactattg caacctactg tactggttct ataccttgta gtgtttgtct 7140

tagtggttta gattctttag acacctatcc ttctttagaa actatacaaa ttaccatttc 7200

atcttttaaa tgggatttaa ctgcttttgg cttagttgca gagtggtttt tggcatatat 7260

tcttttcact aggtttttct atgtacttgg attggctgca atcatgcaat tgtttttcag 7320

ctattttgca gtacatttta ttagtaattc ttggcttatg tggttaataa ttaatcttgt 7380

acaaatggcc ccgatttcag ctatggttag aatgtacatc ttctttgcat cattttatta 7440

tgtatggaaa agttatgtgc atgttgtaga cggttgtaat tcatcaactt gtatgatgtg 7500

ttacaaacgt aatagagcaa caagagtcga atgtacaact attgttaatg gtgttagaag 7560

gtccttttat gtctatgcta atggaggtaa aggcttttgc aaactacaca attggaattg 7620

tgttaattgt gatacattct gtgctggtag tacatttatt agtgatgaag ttgcgagaga 7680

cttgtcacta cagtttaaaa gaccaataaa tcctactgac cagtcttctt acatcgttga 7740

tagtgttaca gtgaagaatg gttccatcca tctttacttt gataaagctg gtcaaaagac 7800

ttatgaaaga cattctctct ctcattttgt taacttagac aacctgagag ctaataacac 7860

taaaggttca ttgcctatta atgttatagt ttttgatggt aaatcaaaat gtgaagaatc 7920

atctgcaaaa tcagcgtctg tttactacag tcagcttatg tgtcaaccta tactgttact 7980

agatcaggca ttagtgtctg atgttggtga tagtgcggaa gttgcagtta aaatgtttga 8040

tgcttacgtt aatacgtttt catcaacttt taacgtacca atggaaaaac tcaaaacact 8100

agttgcaact gcagaagctg aacttgcaaa gaatgtgtcc ttagacaatg tcttatctac 8160

ttttatttca gcagctcggc aagggtttgt tgattcagat gtagaaacta aagatgttgt 8220

tgaatgtctt aaattgtcac atcaatctga catagaagtt actggcgata gttgtaataa 8280

ctatatgctc acctataaca aagttgaaaa catgacaccc cgtgaccttg gtgcttgtat 8340

tgactgtagt gcgcgtcata ttaatgcgca ggtagcaaaa agtcacaaca ttgctttgat 8400

atggaacgtt aaagatttca tgtcattgtc tgaacaacta cgaaaacaaa tacgtagtgc 8460

tgctaaaaag aataacttac cttttaagtt gacatgtgca actactagac aagttgttaa 8520

tgttgtaaca acaaagatag cacttaaggg tggtaaaatt gttaataatt ggttgaagca 8580

gttaattaaa gttacacttg tgttcctttt tgttgctgct attttctatt taataacacc 8640

tgttcatgtc atgtctaaac atactgactt ttcaagtgaa atcataggat acaaggctat 8700

tgatggtggt gtcactcgtg acatagcatc tacagatact tgttttgcta acaaacatgc 8760

tgattttgac acatggttta gccagcgtgg tggtagttat actaatgaca aagcttgccc 8820

attgattgct gcagtcataa caagagaagt gggttttgtc gtgcctggtt tgcctggcac 8880

gatattacgc acaactaatg gtgacttttt gcatttctta cctagagttt ttagtgcagt 8940

tggtaacatc tgttacacac catcaaaact tatagagtac actgactttg caacatcagc 9000

ttgtgttttg gctgctgaat gtacaatttt taaagatgct tctggtaagc cagtaccata 9060

ttgttatgat accaatgtac tagaaggttc tgttgcttat gaaagtttac gccctgacac 9120

acgttatgtg ctcatggatg gctctattat tcaatttcct aacacctacc ttgaaggttc 9180

tgttagagtg gtaacaactt ttgattctga gtactgtagg cacggcactt gtgaaagatc 9240

agaagctggt gtttgtgtat ctactagtgg tagatgggta cttaacaatg attattacag 9300

atctttacca ggagttttct gtggtgtaga tgctgtaaat ttacttacta atatgtttac 9360

accactaatt caacctattg gtgctttgga catatcagca tctatagtag ctggtggtat 9420

tgtagctatc gtagtaacat gccttgccta ctattttatg aggtttagaa gagcttttgg 9480

tgaatacagt catgtagttg cctttaatac tttactattc cttatgtcat tcactgtact 9540

ctgtttaaca ccagtttact cattcttacc tggtgtttat tctgttattt acttgtactt 9600

gacattttat cttactaatg atgtttcttt tttagcacat attcagtgga tggttatgtt 9660

cacaccttta gtacctttct ggataacaat tgcttatatc atttgtattt ccacaaagca 9720

tttctattgg ttctttagta attacctaaa gagacgtgta gtctttaatg gtgtttcctt 9780

tagtactttt gaagaagctg cgctgtgcac ctttttgtta aataaagaaa tgtatctaaa 9840

gttgcgtagt gatgtgctat tacctcttac gcaatataat agatacttag ctctttataa 9900

taagtacaag tattttagtg gagcaatgga tacaactagc tacagagaag ctgcttgttg 9960

tcatctcgca aaggctctca atgacttcag taactcaggt tctgatgttc tttaccaacc 10020

accacaaacc tctatcacct cagctgtttt gcagagtggt tttagaaaaa tggcattccc 10080

atctggtaaa gttgagggtt gtatggtaca agtaacttgt ggtacaacta cacttaacgg 10140

tctttggctt gatgacgtag tttactgtcc aagacatgtg atctgcacct ctgaagacat 10200

gcttaaccct aattatgaag atttactcat tcgtaagtct aatcataatt tcttggtaca 10260

ggctggtaat gttcaactca gggttattgg acattctatg caaaattgtg tacttaagct 10320

taaggttgat acagccaatc ctaagacacc taagtataag tttgttcgca ttcaaccagg 10380

acagactttt tcagtgttag cttgttacaa tggttcacca tctggtgttt accaatgtgc 10440

tatgaggccc aatttcacta ttaagggttc attccttaat ggttcatgtg gtagtgttgg 10500

ttttaacata gattatgact gtgtctcttt ttgttacatg caccatatgg aattaccaac 10560

tggagttcat gctggcacag acttagaagg taacttttat ggaccttttg ttgacaggca 10620

aacagcacaa gcagctggta cggacacaac tattacagtt aatgttttag cttggttgta 10680

cgctgctgtt ataaatggag acaggtggtt tctcaatcga tttaccacaa ctcttaatga 10740

ctttaacctt gtggctatga agtacaatta tgaacctcta acacaagacc atgttgacat 10800

actaggacct ctttctgctc aaactggaat tgccgtttta gatatgtgtg cttcattaaa 10860

agaattactg caaaatggta tgaatggacg taccatattg ggtagtgctt tattagaaga 10920

tgaatttaca ccttttgatg ttgttagaca atgctcaggt gttactttcc aaagtgcagt 10980

gaaaagaaca atcaagggta cacaccactg gttgttactc acaattttga cttcactttt 11040

agttttagtc cagagtactc aatggtcttt gttctttttt ttgtatgaaa atgccttttt 11100

accttttgct atgggtatta ttgctatgtc tgcttttgca atgatgtttg tcaaacataa 11160

gcatgcattt ctctgtttgt ttttgttacc ttctcttgcc actgtagctt attttaatat 11220

ggtctatatg cctgctagtt gggtgatgcg tattatgaca tggttggata tggttgatac 11280

tagtttgtct ggttttaagc taaaagactg tgttatgtat gcatcagctg tagtgttact 11340

aatccttatg acagcaagaa ctgtgtatga tgatggtgct aggagagtgt ggacacttat 11400

gaatgtcttg acactcgttt ataaagttta ttatggtaat gctttagatc aagccatttc 11460

catgtgggct cttataatct ctgttacttc taactactca ggtgtagtta caactgtcat 11520

gtttttggcc agaggtattg tttttatgtg tgttgagtat tgccctattt tcttcataac 11580

tggtaataca cttcagtgta taatgctagt ttattgtttc ttaggctatt tttgtacttg 11640

ttactttggc ctcttttgtt tactcaaccg ctactttaga ctgactcttg gtgtttatga 11700

ttacttagtt tctacacagg agtttagata tatgaattca cagggactac tcccacccaa 11760

gaatagcata gatgccttca aactcaacat taaattgttg ggtgttggtg gcaaaccttg 11820

tatcaaagta gccactgtac agtctaaaat gtcagatgta aagtgcacat cagtagtctt 11880

actctcagtt ttgcaacaac tcagagtaga atcatcatct aaattgtggg ctcaatgtgt 11940

ccagttacac aatgacattc tcttagctaa agatactact gaagcctttg aaaaaatggt 12000

ttcactactt tctgttttgc tttccatgca gggtgctgta gacataaaca agctttgtga 12060

agaaatgctg gacaacaggg caaccttaca agctatagcc tcagagttta gttcccttcc 12120

atcatatgca gcttttgcta ctgctcaaga agcttatgag caggctgttg ctaatggtga 12180

ttctgaagtt gttcttaaaa agttgaagaa gtctttgaat gtggctaaat ctgaatttga 12240

ccgtgatgca gccatgcaac gtaagttgga aaagatggct gatcaagcta tgacccaaat 12300

gtataaacag gctagatctg aggacaagag ggcaaaagtt actagtgcta tgcagacaat 12360

gcttttcact atgcttagaa agttggataa tgatgcactc aacaacatta tcaacaatgc 12420

aagagatggt tgtgttccct tgaacataat acctcttaca acagcagcca aactaatggt 12480

tgtcatacca gactataaca catataaaaa tacgtgtgat ggtacaacat ttacttatgc 12540

atcagcattg tgggaaatcc aacaggttgt agatgcagat agtaaaattg ttcaacttag 12600

tgaaattagt atggacaatt cacctaattt agcatggcct cttattgtaa cagctttaag 12660

ggccaattct gctgtcaaat tacagaataa tgagcttagt cctgttgcac tacgacagat 12720

gtcttgtgct gccggtacta cacaaactgc ttgcactgat gacaatgcgt tagcttacta 12780

caacacaaca aagggaggta ggtttgtact tgcactgtta tccgatttac aggatttgaa 12840

atgggctaga ttccctaaga gtgatggaac tggtactatc tatacagaac tggaaccacc 12900

ttgtaggttt gttacagaca cacctaaagg tcctaaagtg aagtatttat actttattaa 12960

aggattaaac aacctaaata gaggtatggt acttggtagt ttagctgcca cagtacgtct 13020

acaagctggt aatgcaacag aagtgcctgc caattcaact gtattatctt tctgtgcttt 13080

tgctgtagat gctgctaaag cttacaaaga ttatctagct agtgggggac aaccaatcac 13140

taattgtgtt aagatgttgt gtacacacac tggtactggt caggcaataa cagttacacc 13200

ggaagccaat atggatcaag aatcctttgg tggtgcatcg tgttgtctgt actgccgttg 13260

ccacatagat catccaaatc ctaaaggatt ttgtgactta aaaggtaagt atgtacaaat 13320

acctacaact tgtgctaatg accctgtggg ttttacactt aaaaacacag tctgtaccgt 13380

ctgcggtatg tggaaaggtt atggctgtag ttgtgatcaa ctccgcgaac ccatgcttca 13440

gtcagctgat gcacaatcgt ttttaaacgg gtttgcggtg taagtgcagc ccgtcttaca 13500

ccgtgcggca caggcactag tactgatgtc gtatacaggg cttttgacat ctacaatgat 13560

aaagtagctg gttttgctaa attcctaaaa actaattgtt gtcgcttcca agaaaaggac 13620

gaagatgaca atttaattga ttcttacttt gtagttaaga gacacacttt ctctaactac 13680

caacatgaag aaacaattta taatttactt aaggattgtc cagctgttgc taaacatgac 13740

ttctttaagt ttagaataga cggtgacatg gtaccacata tatcacgtca acgtcttact 13800

aaatacacaa tggcagacct cgtctatgct ttaaggcatt ttgatgaagg taattgtgac 13860

acattaaaag aaatacttgt cacatacaat tgttgtgatg atgattattt caataaaaag 13920

gactggtatg attttgtaga aaacccagat atattacgcg tatacgccaa cttaggtgaa 13980

cgtgtacgcc aagctttgtt aaaaacagta caattctgtg atgccatgcg aaatgctggt 14040

attgttggtg tactgacatt agataatcaa gatctcaatg gtaactggta tgatttcggt 14100

gatttcatac aaaccacgcc aggtagtgga gttcctgttg tagattctta ttattcattg 14160

ttaatgccta tattaacctt gaccagggct ttaactgcag agtcacatgt tgacactgac 14220

ttaacaaagc cttacattaa gtgggatttg ttaaaatatg acttcacgga agagaggtta 14280

aaactctttg accgttattt taaatattgg gatcagacat accacccaaa ttgtgttaac 14340

tgtttggatg acagatgcat tctgcattgt gcaaacttta atgttttatt ctctacagtg 14400

ttcccaccta caagttttgg accactagtg agaaaaatat ttgttgatgg tgttccattt 14460

gtagtttcaa ctggatacca cttcagagag ctaggtgttg tacataatca ggatgtaaac 14520

ttacatagct ctagacttag ttttaaggaa ttacttgtgt atgctgctga ccctgctatg 14580

cacgctgctt ctggtaatct attactagat aaacgcacta cgtgcttttc agtagctgca 14640

cttactaaca atgttgcttt tcaaactgtc aaacccggta attttaacaa agacttctat 14700

gactttgctg tgtctaaggg tttctttaag gaaggaagtt ctgttgaatt aaaacacttc 14760

ttctttgctc aggatggtaa tgctgctatc agcgattatg actactatcg ttataatcta 14820

ccaacaatgt gtgatatcag acaactacta tttgtagttg aagttgttga taagtacttt 14880

gattgttacg atggtggctg tattaatgct aaccaagtca tcgtcaacaa cctagacaaa 14940

tcagctggtt ttccatttaa taaatggggt aaggctagac tttattatga ttcaatgagt 15000

tatgaggatc aagatgcact tttcgcatat acaaaacgta atgtcatccc tactataact 15060

caaatgaatc ttaagtatgc cattagtgca aagaatagag ctcgcaccgt agctggtgtc 15120

tctatctgta gtactatgac caatagacag tttcatcaaa aattattgaa atcaatagcc 15180

gccactagag gagctactgt agtaattgga acaagcaaat tctatggtgg ttggcacaac 15240

atgttaaaaa ctgtttatag tgatgtagaa aaccctcacc ttatgggttg ggattatcct 15300

aaatgtgata gagccatgcc taacatgctt agaattatgg cctcacttgt tcttgctcgc 15360

aaacatacaa cgtgttgtag cttgtcacac cgtttctata gattagctaa tgagtgtgct 15420

caagtattga gtgaaatggt catgtgtggc ggttcactat atgttaaacc aggtggaacc 15480

tcatcaggag atgccacaac tgcttatgct aatagtgttt ttaacatttg tcaagctgtc 15540

acggccaatg ttaatgcact tttatctact gatggtaaca aaattgccga taagtatgtc 15600

cgcaatttac aacacagact ttatgagtgt ctctatagaa atagagatgt tgacacagac 15660

tttgtgaatg agttttacgc atatttgcgt aaacatttct caatgatgat actctctgac 15720

gatgctgttg tgtgtttcaa tagcacttat gcatctcaag gtctagtggc tagcataaag 15780

aactttaagt cagttcttta ttatcaaaac aatgttttta tgtctgaagc aaaatgttgg 15840

actgagactg accttactaa aggacctcat gaattttgct ctcaacatac aatgctagtt 15900

aaacagggtg atgattatgt gtaccttcct tacccagatc catcaagaat cctaggggcc 15960

ggctgttttg tagatgatat cgtaaaaaca gatggtacac ttatgattga acggttcgtg 16020

tctttagcta tagatgctta cccacttact aaacatccta atcaggagta tgctgatgtc 16080

tttcatttgt acttacaata cataagaaag ctacatgatg agttaacagg acacatgtta 16140

gacatgtatt ctgttatgct tactaatgat aacacttcaa ggtattggga acctgagttt 16200

tatgaggcta tgtacacacc gcatacagtc ttacaggctg ttggggcttg tgttctttgc 16260

aattcacaga cttcattaag atgtggtgct tgcatacgta gaccattctt atgttgtaaa 16320

tgctgttacg accatgtcat atcaacatca cataaattag tcttgtctgt taatccgtat 16380

gtttgcaatg ctccaggttg tgatgtcaca gatgtgactc aactttactt aggaggtatg 16440

agctattatt gtaaatcaca taaaccaccc attagttttc cattgtgtgc taatggacaa 16500

gtttttggtt tatataaaaa tacatgtgtt ggtagcgata atgttactga ctttaatgca 16560

attgcaacat gtgactggac aaatgctggt gattacattt tagctaacac ctgtactgaa 16620

agactcaagc tttttgcagc agaaacgctc aaagctactg aggagacatt taaactgtct 16680

tatggtattg ctactgtacg tgaagtgctg tctgacagag aattacatct ttcatgggaa 16740

gttggtaaac ctagaccacc acttaaccga aattatgtct ttactggtta tcgtgtaact 16800

aaaaacagta aagtacaaat aggagagtac acctttgaaa aaggtgacta tggtgatgct 16860

gttgtttacc gaggtacaac aacttacaaa ttaaatgttg gtgattattt tgtgctgaca 16920

tcacatacag taatgccatt aagtgcacct acactagtgc cacaagagca ctatgttaga 16980

attactggct tatacccaac actcaatatc tcagatgagt tttctagcaa tgttgcaaat 17040

tatcaaaagg ttggtatgca aaagtattct acactccagg gaccacctgg tactggtaag 17100

agtcattttg ctattggcct agctctctac tacccttctg ctcgcatagt gtatacagct 17160

tgctctcatg ccgctgttga tgcactatgt gagaaggcat taaaatattt gcctatagat 17220

aaatgtagta gaattatacc tgcacgtgct cgtgtagagt gttttgataa attcaaagtg 17280

aattcaacat tagaacagta tgtcttttgt actgtaaatg cattgcctga gacgacagca 17340

gatatagttg tctttgatga aatttcaatg gccacaaatt atgatttgag tgttgtcaat 17400

gccagattac gtgctaagca ctatgtgtac attggcgacc ctgctcaatt acctgcacca 17460

cgcacattgc taactaaggg cacactagaa ccagaatatt tcaattcagt gtgtagactt 17520

atgaaaacta taggtccaga catgttcctc ggaacttgtc ggcgttgtcc tgctgaaatt 17580

gttgacactg tgagtgcttt ggtttatgat aataagctta aagcacataa agacaaatca 17640

gctcaatgct ttaaaatgtt ttataagggt gttatcacgc atgatgtttc atctgcaatt 17700

aacaggccac aaataggcgt ggtaagagaa ttccttacac gtaaccctgc ttggagaaaa 17760

gctgtcttta tttcacctta taattcacag aatgctgtag cctcaaagat tttgggacta 17820

ccaactcaaa ctgttgattc atcacagggc tcagaatatg actatgtcat attcactcaa 17880

accactgaaa cagctcactc ttgtaatgta aacagattta atgttgctat taccagagca 17940

aaagtaggca tactttgcat aatgtctgat agagaccttt atgacaagtt gcaatttaca 18000

agtcttgaaa ttccacgtag gaatgtggca actttacaag ctgaaaatgt aacaggactc 18060

tttaaagatt gtagtaaggt aatcactggg ttacatccta cacaggcacc tacacacctc 18120

agtgttgaca ctaaattcaa aactgaaggt ttatgtgttg acatacctgg catacctaag 18180

gacatgacct atagaagact catctctatg atgggtttta aaatgaatta tcaagttaat 18240

ggttacccta acatgtttat cacccgcgaa gaagctataa gacatgtacg tgcatggatt 18300

ggcttcgatg tcgaggggtg tcatgctact agagaagctg ttggtaccaa tttaccttta 18360

cagctaggtt tttctacagg tgttaaccta gttgctgtac ctacaggtta tgttgataca 18420

cctaataata cagatttttc cagagttagt gctaaaccac cgcctggaga tcaatttaaa 18480

cacctcatac cacttatgta caaaggactt ccttggaatg tagtgcgtat aaagattgta 18540

caaatgttaa gtgacacact taaaaatctc tctgacagag tcgtatttgt cttatgggca 18600

catggctttg agttgacatc tatgaagtat tttgtgaaaa taggacctga gcgcacctgt 18660

tgtctatgtg atagacgtgc cacatgcttt tccactgctt cagacactta tgcctgttgg 18720

catcattcta ttggatttga ttacgtctat aatccgttta tgattgatgt tcaacaatgg 18780

ggttttacag gtaacctaca aagcaaccat gatctgtatt gtcaagtcca tggtaatgca 18840

catgtagcta gttgtgatgc aatcatgact aggtgtctag ctgtccacga gtgctttgtt 18900

aagcgtgttg actggactat tgaatatcct ataattggtg atgaactgaa gattaatgcg 18960

gcttgtagaa aggttcaaca catggttgtt aaagctgcat tattagcaga caaattccca 19020

gttcttcacg acattggtaa ccctaaagct attaagtgtg tacctcaagc tgatgtagaa 19080

tggaagttct atgatgcaca gccttgtagt gacaaagctt ataaaataga agaattattc 19140

tattcttatg ccacacattc tgacaaattc acagatggtg tatgcctatt ttggaattgc 19200

aatgtcgata gatatcctgc taattccatt gtttgtagat ttgacactag agtgctatct 19260

aaccttaact tgcctggttg tgatggtggc agtttgtatg taaataaaca tgcattccac 19320

acaccagctt ttgataaaag tgcttttgtt aatttaaaac aattaccatt tttctattac 19380

tctgacagtc catgtgagtc tcatggaaaa caagtagtgt cagatataga ttatgtacca 19440

ctaaagtctg ctacgtgtat aacacgttgc aatttaggtg gtgctgtctg tagacatcat 19500

gctaatgagt acagattgta tctcgatgct tataacatga tgatctcagc tggctttagc 19560

ttgtgggttt acaaacaatt tgatacttat aacctctgga acacttttac aagacttcag 19620

agtttagaaa atgtggcttt taatgttgta aataagggac actttgatgg acaacagggt 19680

gaagtaccag tttctatcat taataacact gtttacacaa aagttgatgg tgttgatgta 19740

gaattgtttg aaaataaaac aacattacct gttaatgtag catttgagct ttgggctaag 19800

cgcaacatta aaccagtacc agaggtgaaa atactcaata atttgggtgt ggacattgct 19860

gctaatactg tgatctggga ctacaaaaga gatgctccag cacatatatc tactattggt 19920

gtttgttcta tgactgacat agccaagaaa ccaactgaaa cgatttgtgc accactcact 19980

gtcttttttg atggtagagt tgatggtcaa gtagacttat ttagaaatgc ccgtaatggt 20040

gttcttatta cagaaggtag tgttaaaggt ttacaaccat ctgtaggtcc caaacaagct 20100

agtcttaatg gagtcacatt aattggagaa gccgtaaaaa cacagttcaa ttattataag 20160

aaagttgatg gtgttgtcca acaattacct gaaacttact ttactcagag tagaaattta 20220

caagaattta aacccaggag tcaaatggaa attgatttct tagaattagc tatggatgaa 20280

ttcattgaac ggtataaatt agaaggctat gccttcgaac atatcgttta tggagatttt 20340

agtcatagtc agttaggtgg tttacatcta ctgattggac tagctaaacg ttttaaggaa 20400

tcaccttttg aattagaaga ttttattcct atggacagta cagttaaaaa ctatttcata 20460

acagatgcgc aaacaggttc atctaagtgt gtgtgttctg ttattgattt attacttgat 20520

gattttgttg aaataataaa atcccaagat ttatctgtag tttctaaggt tgtcaaagtg 20580

actattgact atacagaaat ttcatttatg ctttggtgta aagatggcca tgtagaaaca 20640

ttttacccaa aattacaatc tagtcaagcg tggcaaccgg gtgttgctat gcctaatctt 20700

tacaaaatgc aaagaatgct attagaaaag tgtgaccttc aaaattatgg tgatagtgca 20760

acattaccta aaggcataat gatgaatgtc gcaaaatata ctcaactgtg tcaatattta 20820

aacacattaa cattagctgt accctataat atgagagtta tacattttgg tgctggttct 20880

gataaaggag ttgcaccagg tacagctgtt ttaagacagt ggttgcctac gggtacgctg 20940

cttgtcgatt cagatcttaa tgactttgtc tctgatgcag attcaacttt gattggtgat 21000

tgtgcaactg tacatacagc taataaatgg gatctcatta ttagtgatat gtacgaccct 21060

aagactaaaa atgttacaaa agaaaatgac tctaaagagg gttttttcac ttacatttgt 21120

gggtttatac aacaaaagct agctcttgga ggttccgtgg ctataaagat aacagaacat 21180

tcttggaatg ctgatcttta taagctcatg ggacacttcg catggtggac agcctttgtt 21240

actaatgtga atgcgtcatc atctgaagca tttttaattg gatgtaatta tcttggcaaa 21300

ccacgcgaac aaatagatgg ttatgtcatg catgcaaatt acatattttg gaggaataca 21360

aatccaattc agttgtcttc ctattcttta tttgacatga gtaaatttcc ccttaaatta 21420

aggggtactg ctgttatgtc tttaaaagaa ggtcaaatca atgatatgat tttatctctt 21480

cttagtaaag gtagacttat aattagagaa aacaacagag ttgttatttc tagtgatgtt 21540

cttgttaaca actaaacgaa caatgtttgt ttttcttgtt ttattgccac tagtctctag 21600

tcagtgtgtt aatcttacaa ccagaactca attaccccct gcatacacta attctttcac 21660

acgtggtgtt tattaccctg acaaagtttt cagatcctca gttttacatt caactcagga 21720

cttgttctta cctttctttt ccaatgttac ttggttccat gctatacatg tctctgggac 21780

caatggtact aagaggtttg ataaccctgt cctaccattt aatgatggtg tttattttgc 21840

ttccactgag aagtctaaca taataagagg ctggattttt ggtactactt tagattcgaa 21900

gacccagtcc ctacttattg ttaataacgc tactaatgtt gttattaaag tctgtgaatt 21960

tcaattttgt aatgatccat ttttgggtgt ttattaccac aaaaacaaca aaagttggat 22020

ggaaagtgag ttcagagttt attctagtgc gaataattgc acttttgaat atgtctctca 22080

gccttttctt atggaccttg aaggaaaaca gggtaatttc aaaaatctta gggaatttgt 22140

gtttaagaat attgatggtt attttaaaat atattctaag cacacgccta ttaatttagt 22200

gcgtgatctc cctcagggtt tttcggcttt agaaccattg gtagatttgc caataggtat 22260

taacatcact aggtttcaaa ctttacttgc tttacataga agttatttga ctcctggtga 22320

ttcttcttca ggttggacag ctggtgctgc agcttattat gtgggttatc ttcaacctag 22380

gacttttcta ttaaaatata atgaaaatgg aaccattaca gatgctgtag actgtgcact 22440

tgaccctctc tcagaaacaa agtgtacgtt gaaatccttc actgtagaaa aaggaatcta 22500

tcaaacttct aactttagag tccaaccaac agaatctatt gttagatttc ctaatattac 22560

aaacttgtgc ccttttggtg aagtttttaa cgccaccaga tttgcatctg tttatgcttg 22620

gaacaggaag agaatcagca actgtgttgc tgattattct gtcctatata attccgcatc 22680

attttccact tttaagtgtt atggagtgtc tcctactaaa ttaaatgatc tctgctttac 22740

taatgtctat gcagattcat ttgtaattag aggtgatgaa gtcagacaaa tcgctccagg 22800

gcaaactgga aagattgctg attataatta taaattacca gatgatttta caggctgcgt 22860

tatagcttgg aattctaaca atcttgattc taaggttggt ggtaattata attacctgta 22920

tagattgttt aggaagtcta atctcaaacc ttttgagaga gatatttcaa ctgaaatcta 22980

tcaggccggt agcacacctt gtaatggtgt tgaaggtttt aattgttact ttcctttaca 23040

atcatatggt ttccaaccca ctaatggtgt tggttaccaa ccatacagag tagtagtact 23100

ttcttttgaa cttctacatg caccagcaac tgtttgtgga cctaaaaagt ctactaattt 23160

ggttaaaaac aaatgtgtca atttcaactt caatggttta acaggcacag gtgttcttac 23220

tgagtctaac aaaaagtttc tgcctttcca acaatttggc agagacattg ctgacactac 23280

tgatgctgtc cgtgatccac agacacttga gattcttgac attacaccat gttcttttgg 23340

tggtgtcagt gttataacac caggaacaaa tacttctaac caggttgctg ttctttatca 23400

ggatgttaac tgcacagaag tccctgttgc tattcatgca gatcaactta ctcctacttg 23460

gcgtgtttat tctacaggtt ctaatgtttt tcaaacacgt gcaggctgtt taataggggc 23520

tgaacatgtc aacaactcat atgagtgtga catacccatt ggtgcaggta tatgcgctag 23580

ttatcagact cagactaatt ctcctcggcg ggcacgtagt gtagctagtc aatccatcat 23640

tgcctacact atgtcacttg gtgcagaaaa ttcagttgct tactctaata actctattgc 23700

catacccaca aattttacta ttagtgttac cacagaaatt ctaccagtgt ctatgaccaa 23760

gacatcagta gattgtacaa tgtacatttg tggtgattca actgaatgca gcaatctttt 23820

gttgcaatat ggcagttttt gtacacaatt aaaccgtgct ttaactggaa tagctgttga 23880

acaagacaaa aacacccaag aagtttttgc acaagtcaaa caaatttaca aaacaccacc 23940

aattaaagat tttggtggtt ttaatttttc acaaatatta ccagatccat caaaaccaag 24000

caagaggtca tttattgaag atctactttt caacaaagtg acacttgcag atgctggctt 24060

catcaaacaa tatggtgatt gccttggtga tattgctgct agagacctca tttgtgcaca 24120

aaagtttaac ggccttactg ttttgccacc tttgctcaca gatgaaatga ttgctcaata 24180

cacttctgca ctgttagcgg gtacaatcac ttctggttgg acctttggtg caggtgctgc 24240

attacaaata ccatttgcta tgcaaatggc ttataggttt aatggtattg gagttacaca 24300

gaatgttctc tatgagaacc aaaaattgat tgccaaccaa tttaatagtg ctattggcaa 24360

aattcaagac tcactttctt ccacagcaag tgcacttgga aaacttcaag atgtggtcaa 24420

ccaaaatgca caagctttaa acacgcttgt taaacaactt agctccaatt ttggtgcaat 24480

ttcaagtgtt ttaaatgata tcctttcacg tcttgacaaa gttgaggctg aagtgcaaat 24540

tgataggttg atcacaggca gacttcaaag tttgcagaca tatgtgactc aacaattaat 24600

tagagctgca gaaatcagag cttctgctaa tcttgctgct actaaaatgt cagagtgtgt 24660

acttggacaa tcaaaaagag ttgatttttg tggaaagggc tatcatctta tgtccttccc 24720

tcagtcagca cctcatggtg tagtcttctt gcatgtgact tatgtccctg cacaagaaaa 24780

gaacttcaca actgctcctg ccatttgtca tgatggaaaa gcacactttc ctcgtgaagg 24840

tgtctttgtt tcaaatggca cacactggtt tgtaacacaa aggaattttt atgaaccaca 24900

aatcattact acagacaaca catttgtgtc tggtaactgt gatgttgtaa taggaattgt 24960

caacaacaca gtttatgatc ctttgcaacc tgaattagac tcattcaagg aggagttaga 25020

taaatatttt aagaatcata catcaccaga tgttgattta ggtgacatct ctggcattaa 25080

tgcttcagtt gtaaacattc aaaaagaaat tgaccgcctc aatgaggttg ccaagaattt 25140

aaatgaatct ctcatcgatc tccaagaact tggaaagtat gagcagtata taaaatggcc 25200

atggtacatt tggctaggtt ttatagctgg cttgattgcc atagtaatgg tgacaattat 25260

gctttgctgt atgaccagtt gctgtagttg tctcaagggc tgttgttctt gtggatcctg 25320

ctgcaaattt gatgaagacg actctgagcc agtgctcaaa ggagtcaaat tacattacac 25380

ataaacgaac ttatggattt gtttatgaga atcttcacaa ttggaactgt aactttgaag 25440

caaggtgaaa tcaaggatgc tactccttca gattttgttc gcgctactgc aacgataccg 25500

atacaagcct cactcccttt cggatggctt attgttggcg ttgcacttct tgctgttttt 25560

cagagcgctt ccaaaatcat aaccctcaaa aagagatggc aactagcact ctccaagggt 25620

gttcactttg tttgcaactt gctgttgttg tttgtaacag tttactcaca ccttttgctc 25680

gttgctgctg gccttgaagc cccttttctc tatctttatg ctttagtcta cttcttgcag 25740

agtataaact ttgtaagaat aataatgagg ctttggcttt gctggaaatg ccgttccaaa 25800

aacccattac tttatgatgc caactatttt ctttgctggc atactaattg ttacgactat 25860

tgtatacctt acaatagtgt aacttcttca attgtcatta cttcaggtga tggcacaaca 25920

agtcctattt ctgaacatga ctaccagatt ggtggttata ctgaaaaatg ggaatctgga 25980

gtaaaagact gtgttgtatt acacagttac ttcacttcag actattacca gctgtactca 26040

actcaattga gtacagacac tggtgttgaa catgttacct tcttcatcta caataaaatt 26100

gttgatgagc ctgaagaaca tgtccaaatt cacacaatcg acggttcatc cggagttgtt 26160

aatccagtaa tggaaccaat ttatgatgaa ccgacgacga ctactagcgt gcctttgtaa 26220

gcacaagctg atgagtacga acttatgtac tcattcgttt cggaagagac aggtacgtta 26280

atagttaata gcgtacttct ttttcttgct ttcgtggtat tcttgctagt tacactagcc 26340

atccttactg cgcttcgatt gtgtgcgtac tgctgcaata ttgttaacgt gagtcttgta 26400

aaaccttctt tttacgttta ctctcgtgtt aaaaatctga attcttctag agttcctgat 26460

cttctggtct aaacgaacta aatattatat tagtttttct gtttggaact ttaattttag 26520

ccatggcaga ttccaacggt actattaccg ttgaagagct taaaaagctc cttgaacaat 26580

ggaacctagt aataggtttc ctattcctta catggatttg tcttctacaa tttgcctatg 26640

ccaacaggaa taggtttttg tatataatta agttaatttt cctctggctg ttatggccag 26700

taactttagc ttgttttgtg cttgctgctg tttacagaat aaattggatc accggtggaa 26760

ttgctatcgc aatggcttgt cttgtaggct tgatgtggct cagctacttc attgcttctt 26820

tcagactgtt tgcgcgtacg cgttccatgt ggtcattcaa tccagaaact aacattcttc 26880

tcaacgtgcc actccatggc actattctga ccagaccgct tctagaaagt gaactcgtaa 26940

tcggagctgt gatccttcgt ggacatcttc gtattgctgg acaccatcta ggacgctgtg 27000

acatcaagga cctgcctaaa gaaatcactg ttgctacatc acgaacgctt tcttattaca 27060

aattgggagc ttcgcagcgt gtagcaggtg actcaggttt tgctgcatac agtcgctaca 27120

ggattggcaa ctataaatta aacacagacc attccagtag cagtgacaat attgctttgc 27180

ttgtacagta agtgacaaca gatgtttcat ctcgttgact ttcaggttac tatagcagag 27240

atattactaa ttattatgag gacttttaaa gtttccattt ggaatcttga ttacatcata 27300

aacctcataa ttaaaaattt atctaagtca ctaactgaga ataaatattc tcaattagat 27360

gaagagcaac caatggagat tgattaaacg aacatgaaaa ttattctttt cttggcactg 27420

ataacactcg ctacttgtga gctttatcac taccaagagt gtgttagagg tacaacagta 27480

cttttaaaag aaccttgctc ttctggaaca tacgagggca attcaccatt tcatcctcta 27540

gctgataaca aatttgcact gacttgcttt agcactcaat ttgcttttgc ttgtcctgac 27600

ggcgtaaaac acgtctatca gttacgtgcc agatcagttt cacctaaact gttcatcaga 27660

caagaggaag ttcaagaact ttactctcca atttttctta ttgttgcggc aatagtgttt 27720

ataacacttt gcttcacact caaaagaaag acagaatgat tgaactttca ttaattgact 27780

tctatttgtg ctttttagcc tttctgctat tccttgtttt aattatgctt attatctttt 27840

ggttctcact tgaactgcaa gatcataatg aaacttgtca cgcctaaacg aacatgaaat 27900

ttcttgtttt cttaggaatc atcacaactg tagctgcatt tcaccaagaa tgtagtttac 27960

agtcatgtac tcaacatcaa ccatatgtag ttgatgaccc gtgtcctatt cacttctatt 28020

ctaaatggta tattagagta ggagctagaa aatcagcacc tttaattgaa ttgtgcgtgg 28080

atgaggctgg ttctaaatca cccattcagt acatcgatat cggtaattat acagtttcct 28140

gtttaccttt tacaattaat tgccaggaac ctaaattggg tagtcttgta gtgcgttgtt 28200

cgttctatga agacttttta gagtatcatg acgttcgtgt tgttttagat ttcatctaaa 28260

cgaacaaact aaaatgtctg ataatggacc ccaaaatcag cgaaatgcac cccgcattac 28320

gtttggtgga ccctcagatt caactggcag taaccagaat ggagaacgca gtggggcgcg 28380

atcaaaacaa cgtcggcccc aaggtttacc caataatact gcgtcttggt tcaccgctct 28440

cactcaacat ggcaaggaag accttaaatt ccctcgagga caaggcgttc caattaacac 28500

caatagcagt ccagatgacc aaattggcta ctaccgaaga gctaccagac gaattcgtgg 28560

tggtgacggt aaaatgaaag atctcagtcc aagatggtat ttctactacc taggaactgg 28620

gccagaagct ggacttccct atggtgctaa caaagacggc atcatatggg ttgcaactga 28680

gggagccttg aatacaccaa aagatcacat tggcacccgc aatcctgcta acaatgctgc 28740

aatcgtgcta caacttcctc aaggaacaac attgccaaaa ggcttctacg cagaagggag 28800

cagaggcggc agtcaagcct cttctcgttc ctcatcacgt agtcgcaaca gttcaagaaa 28860

ttcaactcca ggcagcagta ggggaacttc tcctgctaga atggctggca atggcggtga 28920

tgctgctctt gctttgctgc tgcttgacag attgaaccag cttgagagca aaatgtctgg 28980

taaaggccaa caacaacaag gccaaactgt cactaagaaa tctgctgctg aggcttctaa 29040

gaagcctcgg caaaaacgta ctgccactaa agcatacaat gtaacacaag ctttcggcag 29100

acgtggtcca gaacaaaccc aaggaaattt tggggaccag gaactaatca gacaaggaac 29160

tgattacaaa cattggccgc aaattgcaca atttgccccc agcgcttcag cgttcttcgg 29220

aatgtcgcgc attggcatgg aagtcacacc ttcgggaacg tggttgacct acacaggtgc 29280

catcaaattg gatgacaaag atccaaattt caaagatcaa gtcattttgc tgaataagca 29340

tattgacgca tacaaaacat tcccaccaac agagcctaaa aaggacaaaa agaagaaggc 29400

tgatgaaact caagccttac cgcagagaca gaagaaacag caaactgtga ctcttcttcc 29460

tgctgcagat ttggatgatt tctccaaaca attgcaacaa tccatgagca gtgctgactc 29520

aactcaggcc taaactcatg cagaccacac aaggcagatg ggctatataa acgttttcgc 29580

ttttccgttt acgatatata gtctactctt gtgcagaatg aattctcgta actacatagc 29640

acaagtagat gtagttaact ttaatctcac atagcaatct ttaatcagtg tgtaacatta 29700

gggaggactt gaaagagcca ccacattttc accgaggcca cgcggagtac gatcgagtgt 29760

acagtgaaca atgctaggga gagctgccta tatggaagag ccctaatgtg taaaattaat 29820

tttagtagtg ctatccccat gtgattttaa tagcttctta ggagaatgac aaaaaaaaaa 29880

aaaaaaaaaa aaaaaaaaaa aaa 29903

<210> 2

<211> 7096

<212> PRT

<213> SARS-CoV2

<400> 2

Met Glu Ser Leu Val Pro Gly Phe Asn Glu Lys Thr His Val Gln Leu

1 5 10 15

Ser Leu Pro Val Leu Gln Val Arg Asp Val Leu Val Arg Gly Phe Gly

20 25 30

Asp Ser Val Glu Glu Val Leu Ser Glu Ala Arg Gln His Leu Lys Asp

35 40 45

Gly Thr Cys Gly Leu Val Glu Val Glu Lys Gly Val Leu Pro Gln Leu

50 55 60

Glu Gln Pro Tyr Val Phe Ile Lys Arg Ser Asp Ala Arg Thr Ala Pro

65 70 75 80

His Gly His Val Met Val Glu Leu Val Ala Glu Leu Glu Gly Ile Gln

85 90 95

Tyr Gly Arg Ser Gly Glu Thr Leu Gly Val Leu Val Pro His Val Gly

100 105 110

Glu Ile Pro Val Ala Tyr Arg Lys Val Leu Leu Arg Lys Asn Gly Asn

115 120 125

Lys Gly Ala Gly Gly His Ser Tyr Gly Ala Asp Leu Lys Ser Phe Asp

130 135 140

Leu Gly Asp Glu Leu Gly Thr Asp Pro Tyr Glu Asp Phe Gln Glu Asn

145 150 155 160

Trp Asn Thr Lys His Ser Ser Gly Val Thr Arg Glu Leu Met Arg Glu

165 170 175

Leu Asn Gly Gly Ala Tyr Thr Arg Tyr Val Asp Asn Asn Phe Cys Gly

180 185 190

Pro Asp Gly Tyr Pro Leu Glu Cys Ile Lys Asp Leu Leu Ala Arg Ala

195 200 205

Gly Lys Ala Ser Cys Thr Leu Ser Glu Gln Leu Asp Phe Ile Asp Thr

210 215 220

Lys Arg Gly Val Tyr Cys Cys Arg Glu His Glu His Glu Ile Ala Trp

225 230 235 240

Tyr Thr Glu Arg Ser Glu Lys Ser Tyr Glu Leu Gln Thr Pro Phe Glu

245 250 255

Ile Lys Leu Ala Lys Lys Phe Asp Thr Phe Asn Gly Glu Cys Pro Asn

260 265 270

Phe Val Phe Pro Leu Asn Ser Ile Ile Lys Thr Ile Gln Pro Arg Val

275 280 285

Glu Lys Lys Lys Leu Asp Gly Phe Met Gly Arg Ile Arg Ser Val Tyr

290 295 300

Pro Val Ala Ser Pro Asn Glu Cys Asn Gln Met Cys Leu Ser Thr Leu

305 310 315 320

Met Lys Cys Asp His Cys Gly Glu Thr Ser Trp Gln Thr Gly Asp Phe

325 330 335

Val Lys Ala Thr Cys Glu Phe Cys Gly Thr Glu Asn Leu Thr Lys Glu

340 345 350

Gly Ala Thr Thr Cys Gly Tyr Leu Pro Gln Asn Ala Val Val Lys Ile

355 360 365

Tyr Cys Pro Ala Cys His Asn Ser Glu Val Gly Pro Glu His Ser Leu

370 375 380

Ala Glu Tyr His Asn Glu Ser Gly Leu Lys Thr Ile Leu Arg Lys Gly

385 390 395 400

Gly Arg Thr Ile Ala Phe Gly Gly Cys Val Phe Ser Tyr Val Gly Cys

405 410 415

His Asn Lys Cys Ala Tyr Trp Val Pro Arg Ala Ser Ala Asn Ile Gly

420 425 430

Cys Asn His Thr Gly Val Val Gly Glu Gly Ser Glu Gly Leu Asn Asp

435 440 445

Asn Leu Leu Glu Ile Leu Gln Lys Glu Lys Val Asn Ile Asn Ile Val

450 455 460

Gly Asp Phe Lys Leu Asn Glu Glu Ile Ala Ile Ile Leu Ala Ser Phe

465 470 475 480

Ser Ala Ser Thr Ser Ala Phe Val Glu Thr Val Lys Gly Leu Asp Tyr

485 490 495

Lys Ala Phe Lys Gln Ile Val Glu Ser Cys Gly Asn Phe Lys Val Thr

500 505 510

Lys Gly Lys Ala Lys Lys Gly Ala Trp Asn Ile Gly Glu Gln Lys Ser

515 520 525

Ile Leu Ser Pro Leu Tyr Ala Phe Ala Ser Glu Ala Ala Arg Val Val

530 535 540

Arg Ser Ile Phe Ser Arg Thr Leu Glu Thr Ala Gln Asn Ser Val Arg

545 550 555 560

Val Leu Gln Lys Ala Ala Ile Thr Ile Leu Asp Gly Ile Ser Gln Tyr

565 570 575

Ser Leu Arg Leu Ile Asp Ala Met Met Phe Thr Ser Asp Leu Ala Thr

580 585 590

Asn Asn Leu Val Val Met Ala Tyr Ile Thr Gly Gly Val Val Gln Leu

595 600 605

Thr Ser Gln Trp Leu Thr Asn Ile Phe Gly Thr Val Tyr Glu Lys Leu

610 615 620

Lys Pro Val Leu Asp Trp Leu Glu Glu Lys Phe Lys Glu Gly Val Glu

625 630 635 640

Phe Leu Arg Asp Gly Trp Glu Ile Val Lys Phe Ile Ser Thr Cys Ala

645 650 655

Cys Glu Ile Val Gly Gly Gln Ile Val Thr Cys Ala Lys Glu Ile Lys

660 665 670

Glu Ser Val Gln Thr Phe Phe Lys Leu Val Asn Lys Phe Leu Ala Leu

675 680 685

Cys Ala Asp Ser Ile Ile Ile Gly Gly Ala Lys Leu Lys Ala Leu Asn

690 695 700

Leu Gly Glu Thr Phe Val Thr His Ser Lys Gly Leu Tyr Arg Lys Cys

705 710 715 720

Val Lys Ser Arg Glu Glu Thr Gly Leu Leu Met Pro Leu Lys Ala Pro

725 730 735

Lys Glu Ile Ile Phe Leu Glu Gly Glu Thr Leu Pro Thr Glu Val Leu

740 745 750

Thr Glu Glu Val Val Leu Lys Thr Gly Asp Leu Gln Pro Leu Glu Gln

755 760 765

Pro Thr Ser Glu Ala Val Glu Ala Pro Leu Val Gly Thr Pro Val Cys

770 775 780

Ile Asn Gly Leu Met Leu Leu Glu Ile Lys Asp Thr Glu Lys Tyr Cys

785 790 795 800

Ala Leu Ala Pro Asn Met Met Val Thr Asn Asn Thr Phe Thr Leu Lys

805 810 815

Gly Gly Ala Pro Thr Lys Val Thr Phe Gly Asp Asp Thr Val Ile Glu

820 825 830

Val Gln Gly Tyr Lys Ser Val Asn Ile Thr Phe Glu Leu Asp Glu Arg

835 840 845

Ile Asp Lys Val Leu Asn Glu Lys Cys Ser Ala Tyr Thr Val Glu Leu

850 855 860

Gly Thr Glu Val Asn Glu Phe Ala Cys Val Val Ala Asp Ala Val Ile

865 870 875 880

Lys Thr Leu Gln Pro Val Ser Glu Leu Leu Thr Pro Leu Gly Ile Asp

885 890 895

Leu Asp Glu Trp Ser Met Ala Thr Tyr Tyr Leu Phe Asp Glu Ser Gly

900 905 910

Glu Phe Lys Leu Ala Ser His Met Tyr Cys Ser Phe Tyr Pro Pro Asp

915 920 925

Glu Asp Glu Glu Glu Gly Asp Cys Glu Glu Glu Glu Phe Glu Pro Ser

930 935 940

Thr Gln Tyr Glu Tyr Gly Thr Glu Asp Asp Tyr Gln Gly Lys Pro Leu

945 950 955 960

Glu Phe Gly Ala Thr Ser Ala Ala Leu Gln Pro Glu Glu Glu Gln Glu

965 970 975

Glu Asp Trp Leu Asp Asp Asp Ser Gln Gln Thr Val Gly Gln Gln Asp

980 985 990

Gly Ser Glu Asp Asn Gln Thr Thr Thr Ile Gln Thr Ile Val Glu Val

995 1000 1005

Gln Pro Gln Leu Glu Met Glu Leu Thr Pro Val Val Gln Thr Ile

1010 1015 1020

Glu Val Asn Ser Phe Ser Gly Tyr Leu Lys Leu Thr Asp Asn Val

1025 1030 1035

Tyr Ile Lys Asn Ala Asp Ile Val Glu Glu Ala Lys Lys Val Lys

1040 1045 1050

Pro Thr Val Val Val Asn Ala Ala Asn Val Tyr Leu Lys His Gly

1055 1060 1065

Gly Gly Val Ala Gly Ala Leu Asn Lys Ala Thr Asn Asn Ala Met

1070 1075 1080

Gln Val Glu Ser Asp Asp Tyr Ile Ala Thr Asn Gly Pro Leu Lys

1085 1090 1095

Val Gly Gly Ser Cys Val Leu Ser Gly His Asn Leu Ala Lys His

1100 1105 1110

Cys Leu His Val Val Gly Pro Asn Val Asn Lys Gly Glu Asp Ile

1115 1120 1125

Gln Leu Leu Lys Ser Ala Tyr Glu Asn Phe Asn Gln His Glu Val

1130 1135 1140

Leu Leu Ala Pro Leu Leu Ser Ala Gly Ile Phe Gly Ala Asp Pro

1145 1150 1155

Ile His Ser Leu Arg Val Cys Val Asp Thr Val Arg Thr Asn Val

1160 1165 1170

Tyr Leu Ala Val Phe Asp Lys Asn Leu Tyr Asp Lys Leu Val Ser

1175 1180 1185

Ser Phe Leu Glu Met Lys Ser Glu Lys Gln Val Glu Gln Lys Ile

1190 1195 1200

Ala Glu Ile Pro Lys Glu Glu Val Lys Pro Phe Ile Thr Glu Ser

1205 1210 1215

Lys Pro Ser Val Glu Gln Arg Lys Gln Asp Asp Lys Lys Ile Lys

1220 1225 1230

Ala Cys Val Glu Glu Val Thr Thr Thr Leu Glu Glu Thr Lys Phe

1235 1240 1245

Leu Thr Glu Asn Leu Leu Leu Tyr Ile Asp Ile Asn Gly Asn Leu

1250 1255 1260

His Pro Asp Ser Ala Thr Leu Val Ser Asp Ile Asp Ile Thr Phe

1265 1270 1275

Leu Lys Lys Asp Ala Pro Tyr Ile Val Gly Asp Val Val Gln Glu

1280 1285 1290

Gly Val Leu Thr Ala Val Val Ile Pro Thr Lys Lys Ala Gly Gly

1295 1300 1305

Thr Thr Glu Met Leu Ala Lys Ala Leu Arg Lys Val Pro Thr Asp

1310 1315 1320

Asn Tyr Ile Thr Thr Tyr Pro Gly Gln Gly Leu Asn Gly Tyr Thr

1325 1330 1335

Val Glu Glu Ala Lys Thr Val Leu Lys Lys Cys Lys Ser Ala Phe

1340 1345 1350

Tyr Ile Leu Pro Ser Ile Ile Ser Asn Glu Lys Gln Glu Ile Leu

1355 1360 1365

Gly Thr Val Ser Trp Asn Leu Arg Glu Met Leu Ala His Ala Glu

1370 1375 1380

Glu Thr Arg Lys Leu Met Pro Val Cys Val Glu Thr Lys Ala Ile

1385 1390 1395

Val Ser Thr Ile Gln Arg Lys Tyr Lys Gly Ile Lys Ile Gln Glu

1400 1405 1410

Gly Val Val Asp Tyr Gly Ala Arg Phe Tyr Phe Tyr Thr Ser Lys

1415 1420 1425

Thr Thr Val Ala Ser Leu Ile Asn Thr Leu Asn Asp Leu Asn Glu

1430 1435 1440

Thr Leu Val Thr Met Pro Leu Gly Tyr Val Thr His Gly Leu Asn

1445 1450 1455

Leu Glu Glu Ala Ala Arg Tyr Met Arg Ser Leu Lys Val Pro Ala

1460 1465 1470

Thr Val Ser Val Ser Ser Pro Asp Ala Val Thr Ala Tyr Asn Gly

1475 1480 1485

Tyr Leu Thr Ser Ser Ser Lys Thr Pro Glu Glu His Phe Ile Glu

1490 1495 1500

Thr Ile Ser Leu Ala Gly Ser Tyr Lys Asp Trp Ser Tyr Ser Gly

1505 1510 1515

Gln Ser Thr Gln Leu Gly Ile Glu Phe Leu Lys Arg Gly Asp Lys

1520 1525 1530

Ser Val Tyr Tyr Thr Ser Asn Pro Thr Thr Phe His Leu Asp Gly

1535 1540 1545

Glu Val Ile Thr Phe Asp Asn Leu Lys Thr Leu Leu Ser Leu Arg

1550 1555 1560

Glu Val Arg Thr Ile Lys Val Phe Thr Thr Val Asp Asn Ile Asn

1565 1570 1575

Leu His Thr Gln Val Val Asp Met Ser Met Thr Tyr Gly Gln Gln

1580 1585 1590

Phe Gly Pro Thr Tyr Leu Asp Gly Ala Asp Val Thr Lys Ile Lys

1595 1600 1605

Pro His Asn Ser His Glu Gly Lys Thr Phe Tyr Val Leu Pro Asn

1610 1615 1620

Asp Asp Thr Leu Arg Val Glu Ala Phe Glu Tyr Tyr His Thr Thr

1625 1630 1635

Asp Pro Ser Phe Leu Gly Arg Tyr Met Ser Ala Leu Asn His Thr

1640 1645 1650

Lys Lys Trp Lys Tyr Pro Gln Val Asn Gly Leu Thr Ser Ile Lys

1655 1660 1665

Trp Ala Asp Asn Asn Cys Tyr Leu Ala Thr Ala Leu Leu Thr Leu

1670 1675 1680

Gln Gln Ile Glu Leu Lys Phe Asn Pro Pro Ala Leu Gln Asp Ala

1685 1690 1695

Tyr Tyr Arg Ala Arg Ala Gly Glu Ala Ala Asn Phe Cys Ala Leu

1700 1705 1710

Ile Leu Ala Tyr Cys Asn Lys Thr Val Gly Glu Leu Gly Asp Val

1715 1720 1725

Arg Glu Thr Met Ser Tyr Leu Phe Gln His Ala Asn Leu Asp Ser

1730 1735 1740

Cys Lys Arg Val Leu Asn Val Val Cys Lys Thr Cys Gly Gln Gln

1745 1750 1755

Gln Thr Thr Leu Lys Gly Val Glu Ala Val Met Tyr Met Gly Thr

1760 1765 1770

Leu Ser Tyr Glu Gln Phe Lys Lys Gly Val Gln Ile Pro Cys Thr

1775 1780 1785

Cys Gly Lys Gln Ala Thr Lys Tyr Leu Val Gln Gln Glu Ser Pro

1790 1795 1800

Phe Val Met Met Ser Ala Pro Pro Ala Gln Tyr Glu Leu Lys His

1805 1810 1815

Gly Thr Phe Thr Cys Ala Ser Glu Tyr Thr Gly Asn Tyr Gln Cys

1820 1825 1830

Gly His Tyr Lys His Ile Thr Ser Lys Glu Thr Leu Tyr Cys Ile

1835 1840 1845

Asp Gly Ala Leu Leu Thr Lys Ser Ser Glu Tyr Lys Gly Pro Ile

1850 1855 1860

Thr Asp Val Phe Tyr Lys Glu Asn Ser Tyr Thr Thr Thr Ile Lys

1865 1870 1875

Pro Val Thr Tyr Lys Leu Asp Gly Val Val Cys Thr Glu Ile Asp

1880 1885 1890

Pro Lys Leu Asp Asn Tyr Tyr Lys Lys Asp Asn Ser Tyr Phe Thr

1895 1900 1905

Glu Gln Pro Ile Asp Leu Val Pro Asn Gln Pro Tyr Pro Asn Ala

1910 1915 1920

Ser Phe Asp Asn Phe Lys Phe Val Cys Asp Asn Ile Lys Phe Ala

1925 1930 1935

Asp Asp Leu Asn Gln Leu Thr Gly Tyr Lys Lys Pro Ala Ser Arg

1940 1945 1950

Glu Leu Lys Val Thr Phe Phe Pro Asp Leu Asn Gly Asp Val Val

1955 1960 1965

Ala Ile Asp Tyr Lys His Tyr Thr Pro Ser Phe Lys Lys Gly Ala

1970 1975 1980

Lys Leu Leu His Lys Pro Ile Val Trp His Val Asn Asn Ala Thr

1985 1990 1995

Asn Lys Ala Thr Tyr Lys Pro Asn Thr Trp Cys Ile Arg Cys Leu

2000 2005 2010

Trp Ser Thr Lys Pro Val Glu Thr Ser Asn Ser Phe Asp Val Leu

2015 2020 2025

Lys Ser Glu Asp Ala Gln Gly Met Asp Asn Leu Ala Cys Glu Asp

2030 2035 2040

Leu Lys Pro Val Ser Glu Glu Val Val Glu Asn Pro Thr Ile Gln

2045 2050 2055

Lys Asp Val Leu Glu Cys Asn Val Lys Thr Thr Glu Val Val Gly

2060 2065 2070

Asp Ile Ile Leu Lys Pro Ala Asn Asn Ser Leu Lys Ile Thr Glu

2075 2080 2085

Glu Val Gly His Thr Asp Leu Met Ala Ala Tyr Val Asp Asn Ser

2090 2095 2100

Ser Leu Thr Ile Lys Lys Pro Asn Glu Leu Ser Arg Val Leu Gly

2105 2110 2115

Leu Lys Thr Leu Ala Thr His Gly Leu Ala Ala Val Asn Ser Val

2120 2125 2130

Pro Trp Asp Thr Ile Ala Asn Tyr Ala Lys Pro Phe Leu Asn Lys

2135 2140 2145

Val Val Ser Thr Thr Thr Asn Ile Val Thr Arg Cys Leu Asn Arg

2150 2155 2160

Val Cys Thr Asn Tyr Met Pro Tyr Phe Phe Thr Leu Leu Leu Gln

2165 2170 2175

Leu Cys Thr Phe Thr Arg Ser Thr Asn Ser Arg Ile Lys Ala Ser

2180 2185 2190

Met Pro Thr Thr Ile Ala Lys Asn Thr Val Lys Ser Val Gly Lys

2195 2200 2205

Phe Cys Leu Glu Ala Ser Phe Asn Tyr Leu Lys Ser Pro Asn Phe

2210 2215 2220

Ser Lys Leu Ile Asn Ile Ile Ile Trp Phe Leu Leu Leu Ser Val

2225 2230 2235

Cys Leu Gly Ser Leu Ile Tyr Ser Thr Ala Ala Leu Gly Val Leu

2240 2245 2250

Met Ser Asn Leu Gly Met Pro Ser Tyr Cys Thr Gly Tyr Arg Glu

2255 2260 2265

Gly Tyr Leu Asn Ser Thr Asn Val Thr Ile Ala Thr Tyr Cys Thr

2270 2275 2280

Gly Ser Ile Pro Cys Ser Val Cys Leu Ser Gly Leu Asp Ser Leu

2285 2290 2295

Asp Thr Tyr Pro Ser Leu Glu Thr Ile Gln Ile Thr Ile Ser Ser

2300 2305 2310

Phe Lys Trp Asp Leu Thr Ala Phe Gly Leu Val Ala Glu Trp Phe

2315 2320 2325

Leu Ala Tyr Ile Leu Phe Thr Arg Phe Phe Tyr Val Leu Gly Leu

2330 2335 2340

Ala Ala Ile Met Gln Leu Phe Phe Ser Tyr Phe Ala Val His Phe

2345 2350 2355

Ile Ser Asn Ser Trp Leu Met Trp Leu Ile Ile Asn Leu Val Gln

2360 2365 2370

Met Ala Pro Ile Ser Ala Met Val Arg Met Tyr Ile Phe Phe Ala

2375 2380 2385

Ser Phe Tyr Tyr Val Trp Lys Ser Tyr Val His Val Val Asp Gly

2390 2395 2400

Cys Asn Ser Ser Thr Cys Met Met Cys Tyr Lys Arg Asn Arg Ala

2405 2410 2415

Thr Arg Val Glu Cys Thr Thr Ile Val Asn Gly Val Arg Arg Ser

2420 2425 2430

Phe Tyr Val Tyr Ala Asn Gly Gly Lys Gly Phe Cys Lys Leu His

2435 2440 2445

Asn Trp Asn Cys Val Asn Cys Asp Thr Phe Cys Ala Gly Ser Thr

2450 2455 2460

Phe Ile Ser Asp Glu Val Ala Arg Asp Leu Ser Leu Gln Phe Lys

2465 2470 2475

Arg Pro Ile Asn Pro Thr Asp Gln Ser Ser Tyr Ile Val Asp Ser

2480 2485 2490

Val Thr Val Lys Asn Gly Ser Ile His Leu Tyr Phe Asp Lys Ala

2495 2500 2505

Gly Gln Lys Thr Tyr Glu Arg His Ser Leu Ser His Phe Val Asn

2510 2515 2520

Leu Asp Asn Leu Arg Ala Asn Asn Thr Lys Gly Ser Leu Pro Ile

2525 2530 2535

Asn Val Ile Val Phe Asp Gly Lys Ser Lys Cys Glu Glu Ser Ser

2540 2545 2550

Ala Lys Ser Ala Ser Val Tyr Tyr Ser Gln Leu Met Cys Gln Pro

2555 2560 2565

Ile Leu Leu Leu Asp Gln Ala Leu Val Ser Asp Val Gly Asp Ser

2570 2575 2580

Ala Glu Val Ala Val Lys Met Phe Asp Ala Tyr Val Asn Thr Phe

2585 2590 2595

Ser Ser Thr Phe Asn Val Pro Met Glu Lys Leu Lys Thr Leu Val

2600 2605 2610

Ala Thr Ala Glu Ala Glu Leu Ala Lys Asn Val Ser Leu Asp Asn

2615 2620 2625

Val Leu Ser Thr Phe Ile Ser Ala Ala Arg Gln Gly Phe Val Asp

2630 2635 2640

Ser Asp Val Glu Thr Lys Asp Val Val Glu Cys Leu Lys Leu Ser

2645 2650 2655

His Gln Ser Asp Ile Glu Val Thr Gly Asp Ser Cys Asn Asn Tyr

2660 2665 2670

Met Leu Thr Tyr Asn Lys Val Glu Asn Met Thr Pro Arg Asp Leu

2675 2680 2685

Gly Ala Cys Ile Asp Cys Ser Ala Arg His Ile Asn Ala Gln Val

2690 2695 2700

Ala Lys Ser His Asn Ile Ala Leu Ile Trp Asn Val Lys Asp Phe

2705 2710 2715

Met Ser Leu Ser Glu Gln Leu Arg Lys Gln Ile Arg Ser Ala Ala

2720 2725 2730

Lys Lys Asn Asn Leu Pro Phe Lys Leu Thr Cys Ala Thr Thr Arg

2735 2740 2745

Gln Val Val Asn Val Val Thr Thr Lys Ile Ala Leu Lys Gly Gly

2750 2755 2760

Lys Ile Val Asn Asn Trp Leu Lys Gln Leu Ile Lys Val Thr Leu

2765 2770 2775

Val Phe Leu Phe Val Ala Ala Ile Phe Tyr Leu Ile Thr Pro Val

2780 2785 2790

His Val Met Ser Lys His Thr Asp Phe Ser Ser Glu Ile Ile Gly

2795 2800 2805

Tyr Lys Ala Ile Asp Gly Gly Val Thr Arg Asp Ile Ala Ser Thr

2810 2815 2820

Asp Thr Cys Phe Ala Asn Lys His Ala Asp Phe Asp Thr Trp Phe

2825 2830 2835

Ser Gln Arg Gly Gly Ser Tyr Thr Asn Asp Lys Ala Cys Pro Leu

2840 2845 2850

Ile Ala Ala Val Ile Thr Arg Glu Val Gly Phe Val Val Pro Gly

2855 2860 2865

Leu Pro Gly Thr Ile Leu Arg Thr Thr Asn Gly Asp Phe Leu His

2870 2875 2880

Phe Leu Pro Arg Val Phe Ser Ala Val Gly Asn Ile Cys Tyr Thr

2885 2890 2895

Pro Ser Lys Leu Ile Glu Tyr Thr Asp Phe Ala Thr Ser Ala Cys

2900 2905 2910

Val Leu Ala Ala Glu Cys Thr Ile Phe Lys Asp Ala Ser Gly Lys

2915 2920 2925

Pro Val Pro Tyr Cys Tyr Asp Thr Asn Val Leu Glu Gly Ser Val

2930 2935 2940

Ala Tyr Glu Ser Leu Arg Pro Asp Thr Arg Tyr Val Leu Met Asp

2945 2950 2955

Gly Ser Ile Ile Gln Phe Pro Asn Thr Tyr Leu Glu Gly Ser Val

2960 2965 2970

Arg Val Val Thr Thr Phe Asp Ser Glu Tyr Cys Arg His Gly Thr

2975 2980 2985

Cys Glu Arg Ser Glu Ala Gly Val Cys Val Ser Thr Ser Gly Arg

2990 2995 3000

Trp Val Leu Asn Asn Asp Tyr Tyr Arg Ser Leu Pro Gly Val Phe

3005 3010 3015

Cys Gly Val Asp Ala Val Asn Leu Leu Thr Asn Met Phe Thr Pro

3020 3025 3030

Leu Ile Gln Pro Ile Gly Ala Leu Asp Ile Ser Ala Ser Ile Val

3035 3040 3045

Ala Gly Gly Ile Val Ala Ile Val Val Thr Cys Leu Ala Tyr Tyr

3050 3055 3060

Phe Met Arg Phe Arg Arg Ala Phe Gly Glu Tyr Ser His Val Val

3065 3070 3075

Ala Phe Asn Thr Leu Leu Phe Leu Met Ser Phe Thr Val Leu Cys

3080 3085 3090

Leu Thr Pro Val Tyr Ser Phe Leu Pro Gly Val Tyr Ser Val Ile

3095 3100 3105

Tyr Leu Tyr Leu Thr Phe Tyr Leu Thr Asn Asp Val Ser Phe Leu

3110 3115 3120

Ala His Ile Gln Trp Met Val Met Phe Thr Pro Leu Val Pro Phe

3125 3130 3135

Trp Ile Thr Ile Ala Tyr Ile Ile Cys Ile Ser Thr Lys His Phe

3140 3145 3150

Tyr Trp Phe Phe Ser Asn Tyr Leu Lys Arg Arg Val Val Phe Asn

3155 3160 3165

Gly Val Ser Phe Ser Thr Phe Glu Glu Ala Ala Leu Cys Thr Phe

3170 3175 3180

Leu Leu Asn Lys Glu Met Tyr Leu Lys Leu Arg Ser Asp Val Leu

3185 3190 3195

Leu Pro Leu Thr Gln Tyr Asn Arg Tyr Leu Ala Leu Tyr Asn Lys

3200 3205 3210

Tyr Lys Tyr Phe Ser Gly Ala Met Asp Thr Thr Ser Tyr Arg Glu

3215 3220 3225

Ala Ala Cys Cys His Leu Ala Lys Ala Leu Asn Asp Phe Ser Asn

3230 3235 3240

Ser Gly Ser Asp Val Leu Tyr Gln Pro Pro Gln Thr Ser Ile Thr

3245 3250 3255

Ser Ala Val Leu Gln Ser Gly Phe Arg Lys Met Ala Phe Pro Ser

3260 3265 3270

Gly Lys Val Glu Gly Cys Met Val Gln Val Thr Cys Gly Thr Thr

3275 3280 3285

Thr Leu Asn Gly Leu Trp Leu Asp Asp Val Val Tyr Cys Pro Arg

3290 3295 3300

His Val Ile Cys Thr Ser Glu Asp Met Leu Asn Pro Asn Tyr Glu

3305 3310 3315

Asp Leu Leu Ile Arg Lys Ser Asn His Asn Phe Leu Val Gln Ala

3320 3325 3330

Gly Asn Val Gln Leu Arg Val Ile Gly His Ser Met Gln Asn Cys

3335 3340 3345

Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro Lys Thr Pro Lys

3350 3355 3360

Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Phe Ser Val Leu

3365 3370 3375

Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys Ala Met

3380 3385 3390

Arg Pro Asn Phe Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser Cys

3395 3400 3405

Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys

3410 3415 3420

Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr

3425 3430 3435

Asp Leu Glu Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr

3440 3445 3450

Ala Gln Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu

3455 3460 3465

Ala Trp Leu Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu

3470 3475 3480

Asn Arg Phe Thr Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met

3485 3490 3495

Lys Tyr Asn Tyr Glu Pro Leu Thr Gln Asp His Val Asp Ile Leu

3500 3505 3510

Gly Pro Leu Ser Ala Gln Thr Gly Ile Ala Val Leu Asp Met Cys

3515 3520 3525

Ala Ser Leu Lys Glu Leu Leu Gln Asn Gly Met Asn Gly Arg Thr

3530 3535 3540

Ile Leu Gly Ser Ala Leu Leu Glu Asp Glu Phe Thr Pro Phe Asp

3545 3550 3555

Val Val Arg Gln Cys Ser Gly Val Thr Phe Gln Ser Ala Val Lys

3560 3565 3570

Arg Thr Ile Lys Gly Thr His His Trp Leu Leu Leu Thr Ile Leu

3575 3580 3585

Thr Ser Leu Leu Val Leu Val Gln Ser Thr Gln Trp Ser Leu Phe

3590 3595 3600

Phe Phe Leu Tyr Glu Asn Ala Phe Leu Pro Phe Ala Met Gly Ile

3605 3610 3615

Ile Ala Met Ser Ala Phe Ala Met Met Phe Val Lys His Lys His

3620 3625 3630

Ala Phe Leu Cys Leu Phe Leu Leu Pro Ser Leu Ala Thr Val Ala

3635 3640 3645

Tyr Phe Asn Met Val Tyr Met Pro Ala Ser Trp Val Met Arg Ile

3650 3655 3660

Met Thr Trp Leu Asp Met Val Asp Thr Ser Leu Ser Gly Phe Lys

3665 3670 3675

Leu Lys Asp Cys Val Met Tyr Ala Ser Ala Val Val Leu Leu Ile

3680 3685 3690

Leu Met Thr Ala Arg Thr Val Tyr Asp Asp Gly Ala Arg Arg Val

3695 3700 3705

Trp Thr Leu Met Asn Val Leu Thr Leu Val Tyr Lys Val Tyr Tyr

3710 3715 3720

Gly Asn Ala Leu Asp Gln Ala Ile Ser Met Trp Ala Leu Ile Ile

3725 3730 3735

Ser Val Thr Ser Asn Tyr Ser Gly Val Val Thr Thr Val Met Phe

3740 3745 3750

Leu Ala Arg Gly Ile Val Phe Met Cys Val Glu Tyr Cys Pro Ile

3755 3760 3765

Phe Phe Ile Thr Gly Asn Thr Leu Gln Cys Ile Met Leu Val Tyr

3770 3775 3780

Cys Phe Leu Gly Tyr Phe Cys Thr Cys Tyr Phe Gly Leu Phe Cys

3785 3790 3795

Leu Leu Asn Arg Tyr Phe Arg Leu Thr Leu Gly Val Tyr Asp Tyr

3800 3805 3810

Leu Val Ser Thr Gln Glu Phe Arg Tyr Met Asn Ser Gln Gly Leu

3815 3820 3825

Leu Pro Pro Lys Asn Ser Ile Asp Ala Phe Lys Leu Asn Ile Lys

3830 3835 3840

Leu Leu Gly Val Gly Gly Lys Pro Cys Ile Lys Val Ala Thr Val

3845 3850 3855

Gln Ser Lys Met Ser Asp Val Lys Cys Thr Ser Val Val Leu Leu

3860 3865 3870

Ser Val Leu Gln Gln Leu Arg Val Glu Ser Ser Ser Lys Leu Trp

3875 3880 3885

Ala Gln Cys Val Gln Leu His Asn Asp Ile Leu Leu Ala Lys Asp

3890 3895 3900

Thr Thr Glu Ala Phe Glu Lys Met Val Ser Leu Leu Ser Val Leu

3905 3910 3915

Leu Ser Met Gln Gly Ala Val Asp Ile Asn Lys Leu Cys Glu Glu

3920 3925 3930

Met Leu Asp Asn Arg Ala Thr Leu Gln Ala Ile Ala Ser Glu Phe

3935 3940 3945

Ser Ser Leu Pro Ser Tyr Ala Ala Phe Ala Thr Ala Gln Glu Ala

3950 3955 3960

Tyr Glu Gln Ala Val Ala Asn Gly Asp Ser Glu Val Val Leu Lys

3965 3970 3975

Lys Leu Lys Lys Ser Leu Asn Val Ala Lys Ser Glu Phe Asp Arg

3980 3985 3990

Asp Ala Ala Met Gln Arg Lys Leu Glu Lys Met Ala Asp Gln Ala

3995 4000 4005

Met Thr Gln Met Tyr Lys Gln Ala Arg Ser Glu Asp Lys Arg Ala

4010 4015 4020

Lys Val Thr Ser Ala Met Gln Thr Met Leu Phe Thr Met Leu Arg

4025 4030 4035

Lys Leu Asp Asn Asp Ala Leu Asn Asn Ile Ile Asn Asn Ala Arg

4040 4045 4050

Asp Gly Cys Val Pro Leu Asn Ile Ile Pro Leu Thr Thr Ala Ala

4055 4060 4065

Lys Leu Met Val Val Ile Pro Asp Tyr Asn Thr Tyr Lys Asn Thr

4070 4075 4080

Cys Asp Gly Thr Thr Phe Thr Tyr Ala Ser Ala Leu Trp Glu Ile

4085 4090 4095

Gln Gln Val Val Asp Ala Asp Ser Lys Ile Val Gln Leu Ser Glu

4100 4105 4110

Ile Ser Met Asp Asn Ser Pro Asn Leu Ala Trp Pro Leu Ile Val

4115 4120 4125

Thr Ala Leu Arg Ala Asn Ser Ala Val Lys Leu Gln Asn Asn Glu

4130 4135 4140

Leu Ser Pro Val Ala Leu Arg Gln Met Ser Cys Ala Ala Gly Thr

4145 4150 4155

Thr Gln Thr Ala Cys Thr Asp Asp Asn Ala Leu Ala Tyr Tyr Asn

4160 4165 4170

Thr Thr Lys Gly Gly Arg Phe Val Leu Ala Leu Leu Ser Asp Leu

4175 4180 4185

Gln Asp Leu Lys Trp Ala Arg Phe Pro Lys Ser Asp Gly Thr Gly

4190 4195 4200

Thr Ile Tyr Thr Glu Leu Glu Pro Pro Cys Arg Phe Val Thr Asp

4205 4210 4215

Thr Pro Lys Gly Pro Lys Val Lys Tyr Leu Tyr Phe Ile Lys Gly

4220 4225 4230

Leu Asn Asn Leu Asn Arg Gly Met Val Leu Gly Ser Leu Ala Ala

4235 4240 4245

Thr Val Arg Leu Gln Ala Gly Asn Ala Thr Glu Val Pro Ala Asn

4250 4255 4260

Ser Thr Val Leu Ser Phe Cys Ala Phe Ala Val Asp Ala Ala Lys

4265 4270 4275

Ala Tyr Lys Asp Tyr Leu Ala Ser Gly Gly Gln Pro Ile Thr Asn

4280 4285 4290

Cys Val Lys Met Leu Cys Thr His Thr Gly Thr Gly Gln Ala Ile

4295 4300 4305

Thr Val Thr Pro Glu Ala Asn Met Asp Gln Glu Ser Phe Gly Gly

4310 4315 4320

Ala Ser Cys Cys Leu Tyr Cys Arg Cys His Ile Asp His Pro Asn

4325 4330 4335

Pro Lys Gly Phe Cys Asp Leu Lys Gly Lys Tyr Val Gln Ile Pro

4340 4345 4350

Thr Thr Cys Ala Asn Asp Pro Val Gly Phe Thr Leu Lys Asn Thr

4355 4360 4365

Val Cys Thr Val Cys Gly Met Trp Lys Gly Tyr Gly Cys Ser Cys

4370 4375 4380

Asp Gln Leu Arg Glu Pro Met Leu Gln Ser Ala Asp Ala Gln Ser

4385 4390 4395

Phe Leu Asn Arg Val Cys Gly Val Ser Ala Ala Arg Leu Thr Pro

4400 4405 4410

Cys Gly Thr Gly Thr Ser Thr Asp Val Val Tyr Arg Ala Phe Asp

4415 4420 4425

Ile Tyr Asn Asp Lys Val Ala Gly Phe Ala Lys Phe Leu Lys Thr

4430 4435 4440

Asn Cys Cys Arg Phe Gln Glu Lys Asp Glu Asp Asp Asn Leu Ile

4445 4450 4455

Asp Ser Tyr Phe Val Val Lys Arg His Thr Phe Ser Asn Tyr Gln

4460 4465 4470

His Glu Glu Thr Ile Tyr Asn Leu Leu Lys Asp Cys Pro Ala Val

4475 4480 4485

Ala Lys His Asp Phe Phe Lys Phe Arg Ile Asp Gly Asp Met Val

4490 4495 4500

Pro His Ile Ser Arg Gln Arg Leu Thr Lys Tyr Thr Met Ala Asp

4505 4510 4515

Leu Val Tyr Ala Leu Arg His Phe Asp Glu Gly Asn Cys Asp Thr

4520 4525 4530

Leu Lys Glu Ile Leu Val Thr Tyr Asn Cys Cys Asp Asp Asp Tyr

4535 4540 4545

Phe Asn Lys Lys Asp Trp Tyr Asp Phe Val Glu Asn Pro Asp Ile

4550 4555 4560

Leu Arg Val Tyr Ala Asn Leu Gly Glu Arg Val Arg Gln Ala Leu

4565 4570 4575

Leu Lys Thr Val Gln Phe Cys Asp Ala Met Arg Asn Ala Gly Ile

4580 4585 4590

Val Gly Val Leu Thr Leu Asp Asn Gln Asp Leu Asn Gly Asn Trp

4595 4600 4605

Tyr Asp Phe Gly Asp Phe Ile Gln Thr Thr Pro Gly Ser Gly Val

4610 4615 4620

Pro Val Val Asp Ser Tyr Tyr Ser Leu Leu Met Pro Ile Leu Thr

4625 4630 4635

Leu Thr Arg Ala Leu Thr Ala Glu Ser His Val Asp Thr Asp Leu

4640 4645 4650

Thr Lys Pro Tyr Ile Lys Trp Asp Leu Leu Lys Tyr Asp Phe Thr

4655 4660 4665

Glu Glu Arg Leu Lys Leu Phe Asp Arg Tyr Phe Lys Tyr Trp Asp

4670 4675 4680

Gln Thr Tyr His Pro Asn Cys Val Asn Cys Leu Asp Asp Arg Cys

4685 4690 4695

Ile Leu His Cys Ala Asn Phe Asn Val Leu Phe Ser Thr Val Phe

4700 4705 4710

Pro Pro Thr Ser Phe Gly Pro Leu Val Arg Lys Ile Phe Val Asp

4715 4720 4725

Gly Val Pro Phe Val Val Ser Thr Gly Tyr His Phe Arg Glu Leu

4730 4735 4740

Gly Val Val His Asn Gln Asp Val Asn Leu His Ser Ser Arg Leu

4745 4750 4755

Ser Phe Lys Glu Leu Leu Val Tyr Ala Ala Asp Pro Ala Met His

4760 4765 4770

Ala Ala Ser Gly Asn Leu Leu Leu Asp Lys Arg Thr Thr Cys Phe

4775 4780 4785

Ser Val Ala Ala Leu Thr Asn Asn Val Ala Phe Gln Thr Val Lys

4790 4795 4800

Pro Gly Asn Phe Asn Lys Asp Phe Tyr Asp Phe Ala Val Ser Lys

4805 4810 4815

Gly Phe Phe Lys Glu Gly Ser Ser Val Glu Leu Lys His Phe Phe

4820 4825 4830

Phe Ala Gln Asp Gly Asn Ala Ala Ile Ser Asp Tyr Asp Tyr Tyr

4835 4840 4845

Arg Tyr Asn Leu Pro Thr Met Cys Asp Ile Arg Gln Leu Leu Phe

4850 4855 4860

Val Val Glu Val Val Asp Lys Tyr Phe Asp Cys Tyr Asp Gly Gly

4865 4870 4875

Cys Ile Asn Ala Asn Gln Val Ile Val Asn Asn Leu Asp Lys Ser

4880 4885 4890

Ala Gly Phe Pro Phe Asn Lys Trp Gly Lys Ala Arg Leu Tyr Tyr

4895 4900 4905

Asp Ser Met Ser Tyr Glu Asp Gln Asp Ala Leu Phe Ala Tyr Thr

4910 4915 4920

Lys Arg Asn Val Ile Pro Thr Ile Thr Gln Met Asn Leu Lys Tyr

4925 4930 4935

Ala Ile Ser Ala Lys Asn Arg Ala Arg Thr Val Ala Gly Val Ser

4940 4945 4950

Ile Cys Ser Thr Met Thr Asn Arg Gln Phe His Gln Lys Leu Leu

4955 4960 4965

Lys Ser Ile Ala Ala Thr Arg Gly Ala Thr Val Val Ile Gly Thr

4970 4975 4980

Ser Lys Phe Tyr Gly Gly Trp His Asn Met Leu Lys Thr Val Tyr

4985 4990 4995

Ser Asp Val Glu Asn Pro His Leu Met Gly Trp Asp Tyr Pro Lys

5000 5005 5010

Cys Asp Arg Ala Met Pro Asn Met Leu Arg Ile Met Ala Ser Leu

5015 5020 5025

Val Leu Ala Arg Lys His Thr Thr Cys Cys Ser Leu Ser His Arg

5030 5035 5040

Phe Tyr Arg Leu Ala Asn Glu Cys Ala Gln Val Leu Ser Glu Met

5045 5050 5055

Val Met Cys Gly Gly Ser Leu Tyr Val Lys Pro Gly Gly Thr Ser

5060 5065 5070

Ser Gly Asp Ala Thr Thr Ala Tyr Ala Asn Ser Val Phe Asn Ile

5075 5080 5085

Cys Gln Ala Val Thr Ala Asn Val Asn Ala Leu Leu Ser Thr Asp

5090 5095 5100

Gly Asn Lys Ile Ala Asp Lys Tyr Val Arg Asn Leu Gln His Arg

5105 5110 5115

Leu Tyr Glu Cys Leu Tyr Arg Asn Arg Asp Val Asp Thr Asp Phe

5120 5125 5130

Val Asn Glu Phe Tyr Ala Tyr Leu Arg Lys His Phe Ser Met Met

5135 5140 5145

Ile Leu Ser Asp Asp Ala Val Val Cys Phe Asn Ser Thr Tyr Ala

5150 5155 5160

Ser Gln Gly Leu Val Ala Ser Ile Lys Asn Phe Lys Ser Val Leu

5165 5170 5175

Tyr Tyr Gln Asn Asn Val Phe Met Ser Glu Ala Lys Cys Trp Thr

5180 5185 5190

Glu Thr Asp Leu Thr Lys Gly Pro His Glu Phe Cys Ser Gln His

5195 5200 5205

Thr Met Leu Val Lys Gln Gly Asp Asp Tyr Val Tyr Leu Pro Tyr

5210 5215 5220

Pro Asp Pro Ser Arg Ile Leu Gly Ala Gly Cys Phe Val Asp Asp

5225 5230 5235

Ile Val Lys Thr Asp Gly Thr Leu Met Ile Glu Arg Phe Val Ser

5240 5245 5250

Leu Ala Ile Asp Ala Tyr Pro Leu Thr Lys His Pro Asn Gln Glu

5255 5260 5265

Tyr Ala Asp Val Phe His Leu Tyr Leu Gln Tyr Ile Arg Lys Leu

5270 5275 5280

His Asp Glu Leu Thr Gly His Met Leu Asp Met Tyr Ser Val Met

5285 5290 5295

Leu Thr Asn Asp Asn Thr Ser Arg Tyr Trp Glu Pro Glu Phe Tyr

5300 5305 5310

Glu Ala Met Tyr Thr Pro His Thr Val Leu Gln Ala Val Gly Ala

5315 5320 5325

Cys Val Leu Cys Asn Ser Gln Thr Ser Leu Arg Cys Gly Ala Cys

5330 5335 5340

Ile Arg Arg Pro Phe Leu Cys Cys Lys Cys Cys Tyr Asp His Val

5345 5350 5355

Ile Ser Thr Ser His Lys Leu Val Leu Ser Val Asn Pro Tyr Val

5360 5365 5370

Cys Asn Ala Pro Gly Cys Asp Val Thr Asp Val Thr Gln Leu Tyr

5375 5380 5385

Leu Gly Gly Met Ser Tyr Tyr Cys Lys Ser His Lys Pro Pro Ile

5390 5395 5400

Ser Phe Pro Leu Cys Ala Asn Gly Gln Val Phe Gly Leu Tyr Lys

5405 5410 5415

Asn Thr Cys Val Gly Ser Asp Asn Val Thr Asp Phe Asn Ala Ile

5420 5425 5430

Ala Thr Cys Asp Trp Thr Asn Ala Gly Asp Tyr Ile Leu Ala Asn

5435 5440 5445

Thr Cys Thr Glu Arg Leu Lys Leu Phe Ala Ala Glu Thr Leu Lys

5450 5455 5460

Ala Thr Glu Glu Thr Phe Lys Leu Ser Tyr Gly Ile Ala Thr Val

5465 5470 5475

Arg Glu Val Leu Ser Asp Arg Glu Leu His Leu Ser Trp Glu Val

5480 5485 5490

Gly Lys Pro Arg Pro Pro Leu Asn Arg Asn Tyr Val Phe Thr Gly

5495 5500 5505

Tyr Arg Val Thr Lys Asn Ser Lys Val Gln Ile Gly Glu Tyr Thr

5510 5515 5520

Phe Glu Lys Gly Asp Tyr Gly Asp Ala Val Val Tyr Arg Gly Thr

5525 5530 5535

Thr Thr Tyr Lys Leu Asn Val Gly Asp Tyr Phe Val Leu Thr Ser

5540 5545 5550

His Thr Val Met Pro Leu Ser Ala Pro Thr Leu Val Pro Gln Glu

5555 5560 5565

His Tyr Val Arg Ile Thr Gly Leu Tyr Pro Thr Leu Asn Ile Ser

5570 5575 5580

Asp Glu Phe Ser Ser Asn Val Ala Asn Tyr Gln Lys Val Gly Met

5585 5590 5595

Gln Lys Tyr Ser Thr Leu Gln Gly Pro Pro Gly Thr Gly Lys Ser

5600 5605 5610

His Phe Ala Ile Gly Leu Ala Leu Tyr Tyr Pro Ser Ala Arg Ile

5615 5620 5625

Val Tyr Thr Ala Cys Ser His Ala Ala Val Asp Ala Leu Cys Glu

5630 5635 5640

Lys Ala Leu Lys Tyr Leu Pro Ile Asp Lys Cys Ser Arg Ile Ile

5645 5650 5655

Pro Ala Arg Ala Arg Val Glu Cys Phe Asp Lys Phe Lys Val Asn

5660 5665 5670

Ser Thr Leu Glu Gln Tyr Val Phe Cys Thr Val Asn Ala Leu Pro

5675 5680 5685

Glu Thr Thr Ala Asp Ile Val Val Phe Asp Glu Ile Ser Met Ala

5690 5695 5700

Thr Asn Tyr Asp Leu Ser Val Val Asn Ala Arg Leu Arg Ala Lys

5705 5710 5715

His Tyr Val Tyr Ile Gly Asp Pro Ala Gln Leu Pro Ala Pro Arg

5720 5725 5730

Thr Leu Leu Thr Lys Gly Thr Leu Glu Pro Glu Tyr Phe Asn Ser

5735 5740 5745

Val Cys Arg Leu Met Lys Thr Ile Gly Pro Asp Met Phe Leu Gly

5750 5755 5760

Thr Cys Arg Arg Cys Pro Ala Glu Ile Val Asp Thr Val Ser Ala

5765 5770 5775

Leu Val Tyr Asp Asn Lys Leu Lys Ala His Lys Asp Lys Ser Ala

5780 5785 5790

Gln Cys Phe Lys Met Phe Tyr Lys Gly Val Ile Thr His Asp Val

5795 5800 5805

Ser Ser Ala Ile Asn Arg Pro Gln Ile Gly Val Val Arg Glu Phe

5810 5815 5820

Leu Thr Arg Asn Pro Ala Trp Arg Lys Ala Val Phe Ile Ser Pro

5825 5830 5835

Tyr Asn Ser Gln Asn Ala Val Ala Ser Lys Ile Leu Gly Leu Pro

5840 5845 5850

Thr Gln Thr Val Asp Ser Ser Gln Gly Ser Glu Tyr Asp Tyr Val

5855 5860 5865

Ile Phe Thr Gln Thr Thr Glu Thr Ala His Ser Cys Asn Val Asn

5870 5875 5880

Arg Phe Asn Val Ala Ile Thr Arg Ala Lys Val Gly Ile Leu Cys

5885 5890 5895

Ile Met Ser Asp Arg Asp Leu Tyr Asp Lys Leu Gln Phe Thr Ser

5900 5905 5910

Leu Glu Ile Pro Arg Arg Asn Val Ala Thr Leu Gln Ala Glu Asn

5915 5920 5925

Val Thr Gly Leu Phe Lys Asp Cys Ser Lys Val Ile Thr Gly Leu

5930 5935 5940

His Pro Thr Gln Ala Pro Thr His Leu Ser Val Asp Thr Lys Phe

5945 5950 5955

Lys Thr Glu Gly Leu Cys Val Asp Ile Pro Gly Ile Pro Lys Asp

5960 5965 5970

Met Thr Tyr Arg Arg Leu Ile Ser Met Met Gly Phe Lys Met Asn

5975 5980 5985

Tyr Gln Val Asn Gly Tyr Pro Asn Met Phe Ile Thr Arg Glu Glu

5990 5995 6000

Ala Ile Arg His Val Arg Ala Trp Ile Gly Phe Asp Val Glu Gly

6005 6010 6015

Cys His Ala Thr Arg Glu Ala Val Gly Thr Asn Leu Pro Leu Gln

6020 6025 6030

Leu Gly Phe Ser Thr Gly Val Asn Leu Val Ala Val Pro Thr Gly

6035 6040 6045

Tyr Val Asp Thr Pro Asn Asn Thr Asp Phe Ser Arg Val Ser Ala

6050 6055 6060

Lys Pro Pro Pro Gly Asp Gln Phe Lys His Leu Ile Pro Leu Met

6065 6070 6075

Tyr Lys Gly Leu Pro Trp Asn Val Val Arg Ile Lys Ile Val Gln

6080 6085 6090

Met Leu Ser Asp Thr Leu Lys Asn Leu Ser Asp Arg Val Val Phe

6095 6100 6105

Val Leu Trp Ala His Gly Phe Glu Leu Thr Ser Met Lys Tyr Phe

6110 6115 6120

Val Lys Ile Gly Pro Glu Arg Thr Cys Cys Leu Cys Asp Arg Arg

6125 6130 6135

Ala Thr Cys Phe Ser Thr Ala Ser Asp Thr Tyr Ala Cys Trp His

6140 6145 6150

His Ser Ile Gly Phe Asp Tyr Val Tyr Asn Pro Phe Met Ile Asp

6155 6160 6165

Val Gln Gln Trp Gly Phe Thr Gly Asn Leu Gln Ser Asn His Asp

6170 6175 6180

Leu Tyr Cys Gln Val His Gly Asn Ala His Val Ala Ser Cys Asp

6185 6190 6195

Ala Ile Met Thr Arg Cys Leu Ala Val His Glu Cys Phe Val Lys

6200 6205 6210

Arg Val Asp Trp Thr Ile Glu Tyr Pro Ile Ile Gly Asp Glu Leu

6215 6220 6225

Lys Ile Asn Ala Ala Cys Arg Lys Val Gln His Met Val Val Lys

6230 6235 6240

Ala Ala Leu Leu Ala Asp Lys Phe Pro Val Leu His Asp Ile Gly

6245 6250 6255

Asn Pro Lys Ala Ile Lys Cys Val Pro Gln Ala Asp Val Glu Trp

6260 6265 6270

Lys Phe Tyr Asp Ala Gln Pro Cys Ser Asp Lys Ala Tyr Lys Ile

6275 6280 6285

Glu Glu Leu Phe Tyr Ser Tyr Ala Thr His Ser Asp Lys Phe Thr

6290 6295 6300

Asp Gly Val Cys Leu Phe Trp Asn Cys Asn Val Asp Arg Tyr Pro

6305 6310 6315

Ala Asn Ser Ile Val Cys Arg Phe Asp Thr Arg Val Leu Ser Asn

6320 6325 6330

Leu Asn Leu Pro Gly Cys Asp Gly Gly Ser Leu Tyr Val Asn Lys

6335 6340 6345

His Ala Phe His Thr Pro Ala Phe Asp Lys Ser Ala Phe Val Asn

6350 6355 6360

Leu Lys Gln Leu Pro Phe Phe Tyr Tyr Ser Asp Ser Pro Cys Glu

6365 6370 6375

Ser His Gly Lys Gln Val Val Ser Asp Ile Asp Tyr Val Pro Leu

6380 6385 6390

Lys Ser Ala Thr Cys Ile Thr Arg Cys Asn Leu Gly Gly Ala Val

6395 6400 6405

Cys Arg His His Ala Asn Glu Tyr Arg Leu Tyr Leu Asp Ala Tyr

6410 6415 6420

Asn Met Met Ile Ser Ala Gly Phe Ser Leu Trp Val Tyr Lys Gln

6425 6430 6435

Phe Asp Thr Tyr Asn Leu Trp Asn Thr Phe Thr Arg Leu Gln Ser

6440 6445 6450

Leu Glu Asn Val Ala Phe Asn Val Val Asn Lys Gly His Phe Asp

6455 6460 6465

Gly Gln Gln Gly Glu Val Pro Val Ser Ile Ile Asn Asn Thr Val

6470 6475 6480

Tyr Thr Lys Val Asp Gly Val Asp Val Glu Leu Phe Glu Asn Lys

6485 6490 6495

Thr Thr Leu Pro Val Asn Val Ala Phe Glu Leu Trp Ala Lys Arg

6500 6505 6510

Asn Ile Lys Pro Val Pro Glu Val Lys Ile Leu Asn Asn Leu Gly

6515 6520 6525

Val Asp Ile Ala Ala Asn Thr Val Ile Trp Asp Tyr Lys Arg Asp

6530 6535 6540

Ala Pro Ala His Ile Ser Thr Ile Gly Val Cys Ser Met Thr Asp

6545 6550 6555

Ile Ala Lys Lys Pro Thr Glu Thr Ile Cys Ala Pro Leu Thr Val

6560 6565 6570

Phe Phe Asp Gly Arg Val Asp Gly Gln Val Asp Leu Phe Arg Asn

6575 6580 6585

Ala Arg Asn Gly Val Leu Ile Thr Glu Gly Ser Val Lys Gly Leu

6590 6595 6600

Gln Pro Ser Val Gly Pro Lys Gln Ala Ser Leu Asn Gly Val Thr

6605 6610 6615

Leu Ile Gly Glu Ala Val Lys Thr Gln Phe Asn Tyr Tyr Lys Lys

6620 6625 6630

Val Asp Gly Val Val Gln Gln Leu Pro Glu Thr Tyr Phe Thr Gln

6635 6640 6645

Ser Arg Asn Leu Gln Glu Phe Lys Pro Arg Ser Gln Met Glu Ile

6650 6655 6660

Asp Phe Leu Glu Leu Ala Met Asp Glu Phe Ile Glu Arg Tyr Lys

6665 6670 6675

Leu Glu Gly Tyr Ala Phe Glu His Ile Val Tyr Gly Asp Phe Ser

6680 6685 6690

His Ser Gln Leu Gly Gly Leu His Leu Leu Ile Gly Leu Ala Lys

6695 6700 6705

Arg Phe Lys Glu Ser Pro Phe Glu Leu Glu Asp Phe Ile Pro Met

6710 6715 6720

Asp Ser Thr Val Lys Asn Tyr Phe Ile Thr Asp Ala Gln Thr Gly

6725 6730 6735

Ser Ser Lys Cys Val Cys Ser Val Ile Asp Leu Leu Leu Asp Asp

6740 6745 6750

Phe Val Glu Ile Ile Lys Ser Gln Asp Leu Ser Val Val Ser Lys

6755 6760 6765

Val Val Lys Val Thr Ile Asp Tyr Thr Glu Ile Ser Phe Met Leu

6770 6775 6780

Trp Cys Lys Asp Gly His Val Glu Thr Phe Tyr Pro Lys Leu Gln

6785 6790 6795

Ser Ser Gln Ala Trp Gln Pro Gly Val Ala Met Pro Asn Leu Tyr

6800 6805 6810

Lys Met Gln Arg Met Leu Leu Glu Lys Cys Asp Leu Gln Asn Tyr

6815 6820 6825

Gly Asp Ser Ala Thr Leu Pro Lys Gly Ile Met Met Asn Val Ala

6830 6835 6840

Lys Tyr Thr Gln Leu Cys Gln Tyr Leu Asn Thr Leu Thr Leu Ala

6845 6850 6855

Val Pro Tyr Asn Met Arg Val Ile His Phe Gly Ala Gly Ser Asp

6860 6865 6870

Lys Gly Val Ala Pro Gly Thr Ala Val Leu Arg Gln Trp Leu Pro

6875 6880 6885

Thr Gly Thr Leu Leu Val Asp Ser Asp Leu Asn Asp Phe Val Ser

6890 6895 6900

Asp Ala Asp Ser Thr Leu Ile Gly Asp Cys Ala Thr Val His Thr

6905 6910 6915

Ala Asn Lys Trp Asp Leu Ile Ile Ser Asp Met Tyr Asp Pro Lys

6920 6925 6930

Thr Lys Asn Val Thr Lys Glu Asn Asp Ser Lys Glu Gly Phe Phe

6935 6940 6945

Thr Tyr Ile Cys Gly Phe Ile Gln Gln Lys Leu Ala Leu Gly Gly

6950 6955 6960

Ser Val Ala Ile Lys Ile Thr Glu His Ser Trp Asn Ala Asp Leu

6965 6970 6975

Tyr Lys Leu Met Gly His Phe Ala Trp Trp Thr Ala Phe Val Thr

6980 6985 6990

Asn Val Asn Ala Ser Ser Ser Glu Ala Phe Leu Ile Gly Cys Asn

6995 7000 7005

Tyr Leu Gly Lys Pro Arg Glu Gln Ile Asp Gly Tyr Val Met His

7010 7015 7020

Ala Asn Tyr Ile Phe Trp Arg Asn Thr Asn Pro Ile Gln Leu Ser

7025 7030 7035

Ser Tyr Ser Leu Phe Asp Met Ser Lys Phe Pro Leu Lys Leu Arg

7040 7045 7050

Gly Thr Ala Val Met Ser Leu Lys Glu Gly Gln Ile Asn Asp Met

7055 7060 7065

Ile Leu Ser Leu Leu Ser Lys Gly Arg Leu Ile Ile Arg Glu Asn

7070 7075 7080

Asn Arg Val Val Ile Ser Ser Asp Val Leu Val Asn Asn

7085 7090 7095

<210> 3

<211> 1273

<212> PRT

<213> SARS-CoV2

<400> 3

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val

1 5 10 15

Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe

20 25 30

Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu

35 40 45

His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp

50 55 60

Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp

65 70 75 80

Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu

85 90 95

Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser

100 105 110

Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile

115 120 125

Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr

130 135 140

Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr

145 150 155 160

Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu

165 170 175

Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe

180 185 190

Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr

195 200 205

Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu

210 215 220

Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr

225 230 235 240

Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser

245 250 255

Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro

260 265 270

Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala

275 280 285

Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys

290 295 300

Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val

305 310 315 320

Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys

325 330 335

Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala

340 345 350

Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu

355 360 365

Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro

370 375 380

Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe

385 390 395 400

Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly

405 410 415

Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys

420 425 430

Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn

435 440 445

Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe

450 455 460

Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys

465 470 475 480

Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly

485 490 495

Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val

500 505 510

Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys

515 520 525

Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn

530 535 540

Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu

545 550 555 560

Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val

565 570 575

Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe

580 585 590

Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val

595 600 605

Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile

610 615 620

His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser

625 630 635 640

Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val

645 650 655

Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala

660 665 670

Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala

675 680 685

Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser

690 695 700

Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile

705 710 715 720

Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val

725 730 735

Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu

740 745 750

Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr

755 760 765

Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln

770 775 780

Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe

785 790 795 800

Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser

805 810 815

Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly

820 825 830

Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp

835 840 845

Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu

850 855 860

Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly

865 870 875 880

Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile

885 890 895

Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr

900 905 910

Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn

915 920 925

Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala

930 935 940

Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn

945 950 955 960

Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val

965 970 975

Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln

980 985 990

Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val

995 1000 1005

Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn

1010 1015 1020

Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys

1025 1030 1035

Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro

1040 1045 1050

Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val

1055 1060 1065

Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His

1070 1075 1080

Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn

1085 1090 1095

Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln

1100 1105 1110

Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val

1115 1120 1125

Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro

1130 1135 1140

Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn

1145 1150 1155

His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn

1160 1165 1170

Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu

1175 1180 1185

Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu

1190 1195 1200

Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu

1205 1210 1215

Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met

1220 1225 1230

Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys

1235 1240 1245

Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro

1250 1255 1260

Val Leu Lys Gly Val Lys Leu His Tyr Thr

1265 1270

<210> 4

<211> 22

<212> DNA

<213> Artificial Sequence (Artificial Sequence)

<220>

<221>

<222>

<223> Artificial Sequence (Artificial Sequence)

<400> 4

tgactgtgaa cgttcgagat ga 22

<210> 5

<211> 11

<212> PRT

<213> Artificial Sequence (Artificial Sequence)

<220>

<221>

<222>

<223> Artificial Sequence (Artificial Sequence)

<400> 5

Lys Leu Lys Leu Leu Leu Leu Leu Lys Leu Lys

1 5 10

<210> 6

<211> 26

<212> DNA

<213> Artificial Sequence (Artificial Sequence)

<220>

<221>

<222>

<223> Artificial Sequence (Artificial Sequence)

<220>

<221> misc_feature

<222> (1)..(26)

<223> n = deoxyinosine

<400> 6

ncncncncnc ncncncncnc ncncnc 26

<210> 7

<211> 20

<212> DNA

<213> Artificial Sequence (Artificial Sequence)

<220>

<221>

<222>

<223> Artificial Sequence (Artificial Sequence)

<400> 7

tccatgacgt tcctgacgtt 20

<210> 8

<211> 24

<212> DNA

<213> Artificial Sequence (Artificial Sequence)

<220>

<221>

<222>

<223> Artificial Sequence (Artificial Sequence)

<400> 8

tcgtcgtttt gtcgttttgt cgtt 24

<210> 9

<211> 29867

<212> DNA

<213> SARS-CoV2

<220>

<221> misc_feature

<222> (11083)..(11083)

<223> n is a, c, g or t

<400> 9

attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct 60

gttctctaaa cgaactttaa aatctgtgtg gctgtcactc ggctgcatgc ttagtgcact 120

cacgcagtat aattaataac taattactgt cgttgacagg acacgagtaa ctcgtctatc 180

ttctgcaggc tgcttacggt ttcgtccgtg ttgcagccga tcatcagcac atctaggttt 240

cgtccgggtg tgaccgaaag gtaagatgga gagccttgtc cctggtttca acgagaaaac 300

acacgtccaa ctcagtttgc ctgttttaca ggttcgcgac gtgctcgtac gtggctttgg 360

agactccgtg gaggaggtct tatcagaggc acgtcaacat cttaaagatg gcacttgtgg 420

cttagtagaa gttgaaaaag gcgttttgcc tcaacttgaa cagccctatg tgttcatcaa 480

acgttcggat gctcgaactg cacctcatgg tcatgttatg gttgagctgg tagcagaact 540

cgaaggcatt cagtacggtc gtagtggtga gacacttggt gtccttgtcc ctcatgtggg 600

cgaaatacca gtggcttacc gcaaggttct tcttcgtaag aacggtaata aaggagctgg 660

tggccatagt tacggcgccg atctaaagtc atttgactta ggcgacgagc ttggcactga 720

tccttatgaa gattttcaag aaaactggaa cactaaacat agcagtggtg ttacccgtga 780

actcatgcgt gagcttaacg gaggggcata cactcgctat gtcgataaca acttctgtgg 840

ccctgatggc taccctcttg agtgcattaa agaccttcta gcacgtgctg gtaaagcttc 900

atgcactttg tccgaacaac tggactttat tgacactaag aggggtgtat actgctgccg 960

tgaacatgag catgaaattg cttggtacac ggaacgttct gaaaagagct atgaattgca 1020

gacacctttt gaaattaaat tggcaaagaa atttgacacc ttcaatgggg aatgtccaaa 1080

ttttgtattt cccttaaatt ccataatcaa gactattcaa ccaagggttg aaaagaaaaa 1140

gcttgatggc tttatgggta gaattcgatc tgtctatcca gttgcgtcac caaatgaatg 1200

caaccaaatg tgcctttcaa ctctcatgaa gtgtgatcat tgtggtgaaa cttcatggca 1260

gacgggcgat tttgttaaag ccacttgcga attttgtggc actgagaatt tgactaaaga 1320

aggtgccact acttgtggtt acttacccca aaatgctgtt gttaaaattt attgtccagc 1380

atgtcacaat tcagaagtag gacctgagca tagtcttgcc gaataccata atgaatctgg 1440

cttgaaaacc attcttcgta agggtggtcg cactattgcc tttggaggct gtgtgttctc 1500

ttatgttggt tgccataaca agtgtgccta ttgggttcca cgtgctagcg ctaacatagg 1560

ttgtaaccat acaggtgttg ttggagaagg ttccgaaggt cttaatgaca accttcttga 1620

aatactccaa aaagagaaag tcaacatcaa tattgttggt gactttaaac ttaatgaaga 1680

gatcgccatt attttggcat ctttttctgc ttccacaagt gcttttgtgg aaactgtgaa 1740

aggtttggat tataaagcat tcaaacaaat tgttgaatcc tgtggtaatt ttaaagttac 1800

aaaaggaaaa gctaaaaaag gtgcctggaa tattggtgaa cagaaatcaa tactgagtcc 1860

tctttatgca tttgcatcag aggctgctcg tgttgtacga tcaattttct cccgcactct 1920

tgaaactgct caaaattctg tgcgtgtttt acagaaggcc gctataacaa tactagatgg 1980

aatttcacag tattcactga gactcattga tgctatgatg ttcacatctg atttggctac 2040

taacaatcta gttgtaatgg cctacattac aggtggtgtt gttcagttga cttcgcagtg 2100

gctaactaac atctttggca ctgtttatga aaaactcaaa cccgtccttg attggcttga 2160

agagaagttt aaggaaggtg tagagtttct tagagacggt tgggaaattg ttaaatttat 2220

ctcaacctgt gcttgtgaaa ttgtcggtgg acaaattgtc acctgtgcta aggaaattaa 2280

ggagagtgtt cagacattct ttaagcttgt aaataaattt ttggctttgt gtgctgactc 2340

tatcattatt ggtggagcta aacttaaagc cttgaattta ggtgaaacat ttgtcacgca 2400

ctcaaaggga ttgtacagaa agtgtgttaa atccagagaa gaaactggcc tactcatgcc 2460

tctaaaagcc ccaaaagaaa ttatcttctt agagggagaa acacttccca cagaagtgtt 2520

aacagaggaa gttgtcttga aaactggtga tttacaacca ttagaacaac ctactagtga 2580

agctgttgaa gctccattgg ttggtacacc agtttgtatt aacgggctta tgttgctcga 2640

aatcaaagac acagaaaagt actgtgccct tgcacctaat atgatggtaa caaacaatac 2700

cttcacactc aaaggcggtg caccaacaaa ggttactttt ggtgatgaca ctgtgataga 2760

agtgcaaggt tacaagagtg tgaatatcac ttttgaactt gatgaaagga ttgataaagt 2820

acttaatgag aagtgctctg cctatacagt tgaactcggt acagaagtaa atgagttcgc 2880

ctgtgttgtg gcagatgctg tcataaaaac tttgcaacca gtatctgaat tacttacacc 2940

actgggcatt gatttagatg agtggagtat ggctacatac tacttatttg atgagtctgg 3000

tgagtttaaa ttggcttcac atatgtattg ttctttctac cctccagatg aggatgaaga 3060

agaaggtgat tgtgaagaag aagagtttga gccatcaact caatatgagt atggtactga 3120

agatgattac caaggtaaac ctttggaatt tggtgccact tctgctgctc ttcaacctga 3180

agaagagcaa gaagaagatt ggttagatga tgatagtcaa caaactgttg gtcaacaaga 3240

cggcagtgag gacaatcaga caactactat tcaaacaatt gttgaggttc aacctcaatt 3300

agagatggaa cttacaccag ttgttcagac tattgaagtg aatagtttta gtggttattt 3360

aaaacttact gacaatgtat acattaaaaa tgcagacatt gtggaagaag ctaaaaaggt 3420

aaaaccaaca gtggttgtta atgcagccaa tgtttacctt aaacatggag gaggtgttgc 3480

aggagcctta aataaggcta ctaacaatgc catgcaagtt gaatctgatg attacatagc 3540

tactaatgga ccacttaaag tgggtggtag ttgtgtttta agcggacaca atcttgctaa 3600

acactgtctt catgttgtcg gcccaaatgt taacaaaggt gaagacattc aacttcttaa 3660

gagtgcttat gaaaatttta atcagcacga agttctactt gcaccattat tatcagctgg 3720

tatttttggt gctgacccta tacattcttt aagagtttgt gtagatactg ttcgcacaaa 3780

tgtctactta gctgtctttg ataaaaatct ctatgacaaa cttgtttcaa gctttttgga 3840

aatgaagagt gaaaagcaag ttgaacaaaa gatcgctgag attcctaaag aggaagttaa 3900

gccatttata actgaaagta aaccttcagt tgaacagaga aaacaagatg ataagaaaat 3960

caaagcttgt gttgaagaag ttacaacaac tctggaagaa actaagttcc tcacagaaaa 4020

cttgttactt tatattgaca ttaatggcaa tcttcatcca gattctgcca ctcttgttag 4080

tgacattgac atcactttct taaagaaaga tgctccatat atagtgggtg atgttgttca 4140

agagggtgtt ttaactgctg tggttatacc tactaaaaag gctggtggca ctactgaaat 4200

gctagcgaaa gctttgagaa aagtgccaac agacaattat ataaccactt acccgggtca 4260

gggtttaaat ggttacactg tagaggaggc aaagacagtg cttaaaaagt gtaaaagtgc 4320

cttttacatt ctaccatcta ttatctctaa tgagaagcaa gaaattcttg gaactgtttc 4380

ttggaatttg cgagaaatgc ttgcacatgc agaagaaaca cgcaaattaa tgcctgtctg 4440

tgtggaaact aaagccatag tttcaactat acagcgtaaa tataagggta ttaaaataca 4500

agagggtgtg gttgattatg gtgctagatt ttacttttac accagtaaaa caactgtagc 4560

gtcacttatc aacacactta acgatctaaa tgaaactctt gttacaatgc cacttggcta 4620

tgtaacacat ggcttaaatt tggaagaagc tgctcggtat atgagatctc tcaaagtgcc 4680

agctacagtt tctgtttctt cacctgatgc tgttacagcg tataatggtt atcttacttc 4740

ttcttctaaa acacctgaag aacattttat tgaaaccatc tcacttgctg gttcctataa 4800

agattggtcc tattctggac aatctacaca actaggtata gaatttctta agagaggtga 4860

taaaagtgta tattacacta gtaatcctac cacattccac ctagatggtg aagttatcac 4920

ctttgacaat cttaagacac ttctttcttt gagagaagtg aggactatta aggtgtttac 4980

aacagtagac aacattaacc tccacacgca agttgtggac atgtcaatga catatggaca 5040

acagtttggt ccaacttatt tggatggagc tgatgttact aaaataaaac ctcataattc 5100

acatgaaggt aaaacatttt atgttttacc taatgatgac actctacgtg ttgaggcttt 5160

tgagtactac cacacaactg atcctagttt tctgggtagg tacatgtcag cattaaatca 5220

cactaaaaag tggaaatacc cacaagttaa tggtttaact tctattaaat gggcagataa 5280

caactgttat cttgccactg cattgttaac actccaacaa atagagttga agtttaatcc 5340

acctgctcta caagatgctt attacagagc aagggctggt gaagctgcta acttttgtgc 5400

acttatctta gcctactgta ataagacagt aggtgagtta ggtgatgtta gagaaacaat 5460

gagttacttg tttcaacatg ccaatttaga ttcttgcaaa agagtcttga acgtggtgtg 5520

taaaacttgt ggacaacagc agacaaccct taagggtgta gaagctgtta tgtacatggg 5580

cacactttct tatgaacaat ttaagaaagg tgttcagata ccttgtacgt gtggtaaaca 5640

agctacaaaa tatctagtac aacaggagtc accttttgtt atgatgtcag caccacctgc 5700

tcagtatgaa cttaagcatg gtacatttac ttgtgctagt gagtacactg gtaattacca 5760

gtgtggtcac tataaacata taacttctaa agaaactttg tattgcatag acggtgcttt 5820

acttacaaag tcctcagaat acaaaggtcc tattacggat gttttctaca aagaaaacag 5880

ttacacaaca accataaaac cagttactta taaattggat ggtgttgttt gtacagaaat 5940

tgaccctaag ttggacaatt attataagaa agacaattct tatttcacag agcaaccaat 6000

tgatcttgta ccaaaccaac catatccaaa cgcaagcttc gataatttta agtttgtatg 6060

tgataatatc aaatttgctg atgatttaaa ccagttaact ggttataaga aacctgcttc 6120

aagagagctt aaagttacat ttttccctga cttaaatggt gatgtggtgg ctattgatta 6180

taaacactac acaccctctt ttaagaaagg agctaaattg ttacataaac ctattgtttg 6240

gcatgttaac aatgcaacta ataaagccac gtataaacca aatacctggt gtatacgttg 6300

tctttggagc acaaaaccag ttgaaacatc aaattcgttt gatgtactga agtcagagga 6360

cgcgcaggga atggataatc ttgcctgcga agatctaaaa ccagtctctg aagaagtagt 6420

ggaaaatcct accatacaga aagacgttct tgagtgtaat gtgaaaacta ccgaagttgt 6480

aggagacatt atacttaaac cagcaaataa tagtttaaaa attacagaag aggttggcca 6540

cacagatcta atggctgctt atgtagacaa ttctagtctt actattaaga aacctaatga 6600

attatctaga gtattaggtt tgaaaaccct tgctactcat ggtttagctg ctgttaatag 6660

tgtcccttgg gatactatag ctaattatgc taagcctttt cttaacaaag ttgttagtac 6720

aactactaac atagttacac ggtgtttaaa ccgtgtttgt actaattata tgccttattt 6780

ctttacttta ttgctacaat tgtgtacttt tactagaagt acaaattcta gaattaaagc 6840

atctatgccg actactatag caaagaatac tgttaagagt gtcggtaaat tttgtctaga 6900

ggcttcattt aattatttga agtcacctaa tttttctaaa ctgataaata ttataatttg 6960

gtttttacta ttaagtgttt gcctaggttc tttaatctac tcaaccgctg ctttaggtgt 7020

tttaatgtct aatttaggca tgccttctta ctgtactggt tacagagaag gctatttgaa 7080

ctctactaat gtcactattg caacctactg tactggttct ataccttgta gtgtttgtct 7140

tagtggttta gattctttag acacctatcc ttctttagaa actatacaaa ttaccatttc 7200

atcttttaaa tgggatttaa ctgcttttgg cttagttgca gagtggtttt tggcatatat 7260

tcttttcact aggtttttct atgtacttgg attggctgca atcatgcaat tgtttttcag 7320

ctattttgca gtacatttta ttagtaattc ttggcttatg tggttaataa ttaatcttgt 7380

acaaatggcc ccgatttcag ctatggttag aatgtacatc ttctttgcat cattttatta 7440

tgtatggaaa agttatgtgc atgttgtaga cggttgtaat tcatcaactt gtatgatgtg 7500

ttacaaacgt aatagagcaa caagagtcga atgtacaact attgttaatg gtgttagaag 7560

gtccttttat gtctatgcta atggaggtaa aggcttttgc aaactacaca attggaattg 7620

tgttaattgt gatacattct gtgctggtag tacatttatt agtgatgaag ttgcgagaga 7680

cttgtcacta cagtttaaaa gaccaataaa tcctactgac cagtcttctt acatcgttga 7740

tagtgttaca gtgaagaatg gttccatcca tctttacttt gataaagctg gtcaaaagac 7800

ttatgaaaga cattctctct ctcattttgt taacttagac aacctgagag ctaataacac 7860

taaaggttca ttgcctatta atgttatagt ttttgatggt aaatcaaaat gtgaagaatc 7920

atctgcaaaa tcagcgtctg tttactacag tcagcttatg tgtcaaccta tactgttact 7980

agatcaggca ttagtgtctg atgttggtga tagtgcggaa gttgcagtta aaatgtttga 8040

tgcttacgtt aatacgtttt catcaacttt taacgtacca atggaaaaac tcaaaacact 8100

agttgcaact gcagaagctg aacttgcaaa gaatgtgtcc ttagacaatg tcttatctac 8160

ttttatttca gcagctcggc aagggtttgt tgattcagat gtagaaacta aagatgttgt 8220

tgaatgtctt aaattgtcac atcaatctga catagaagtt actggcgata gttgtaataa 8280

ctatatgctc acctataaca aagttgaaaa catgacaccc cgtgaccttg gtgcttgtat 8340

tgactgtagt gcgcgtcata ttaatgcgca ggtagcaaaa agtcacaaca ttgctttgat 8400

atggaacgtt aaagatttca tgtcattgtc tgaacaacta cgaaaacaaa tacgtagtgc 8460

tgctaaaaag aataacttac cttttaagtt gacatgtgca actactagac aagttgttaa 8520

tgttgtaaca acaaagatag cacttaaggg tggtaaaatt gttaataatt ggttgaagca 8580

gttaattaaa gttacacttg tgttcctttt tgttgctgct attttctatt taataacacc 8640

tgttcatgtc atgtctaaac atactgactt ttcaagtgaa atcataggat acaaggctat 8700

tgatggtggt gtcactcgtg acatagcatc tacagatact tgttttgcta acaaacatgc 8760

tgattttgac acatggttta gccagcgtgg tggtagttat actaatgaca aagcttgccc 8820

attgattgct gcagtcataa caagagaagt gggttttgtc gtgcctggtt tgcctggcac 8880

gatattacgc acaactaatg gtgacttttt gcatttctta cctagagttt ttagtgcagt 8940

tggtaacatc tgttacacac catcaaaact tatagagtac actgactttg caacatcagc 9000

ttgtgttttg gctgctgaat gtacaatttt taaagatgct tctggtaagc cagtaccata 9060

ttgttatgat accaatgtac tagaaggttc tgttgcttat gaaagtttac gccctgacac 9120

acgttatgtg ctcatggatg gctctattat tcaatttcct aacacctacc ttgaaggttc 9180

tgttagagtg gtaacaactt ttgattctga gtactgtagg cacggcactt gtgaaagatc 9240

agaagctggt gtttgtgtat ctactagtgg tagatgggta cttaacaatg attattacag 9300

atctttacca ggagttttct gtggtgtaga tgctgtaaat ttacttacta atatgtttac 9360

accactaatt caacctattg gtgctttgga catatcagca tctatagtag ctggtggtat 9420

tgtagctatc gtagtaacat gccttgccta ctattttatg aggtttagaa gagcttttgg 9480

tgaatacagt catgtagttg cctttaatac tttactattc cttatgtcat tcactgtact 9540

ctgtttaaca ccagtttact cattcttacc tggtgtttat tctgttattt acttgtactt 9600

gacattttat cttactaatg atgtttcttt tttagcacat attcagtgga tggttatgtt 9660

cacaccttta gtacctttct ggataacaat tgcttatatc atttgtattt ccacaaagca 9720

tttctattgg ttctttagta attacctaaa gagacgtgta gtctttaatg gtgtttcctt 9780

tagtactttt gaagaagctg cgctgtgcac ctttttgtta aataaagaaa tgtatctaaa 9840

gttgcgtagt gatgtgctat tacctcttac gcaatataat agatacttag ctctttataa 9900

taagtacaag tattttagtg gagcaatgga tacaactagc tacagagaag ctgcttgttg 9960

tcatctcgca aaggctctca atgacttcag taactcaggt tctgatgttc tttaccaacc 10020

accacaaacc tctatcacct cagctgtttt gcagagtggt tttagaaaaa tggcattccc 10080

atctggtaaa gttgagggtt gtatggtaca agtaacttgt ggtacaacta cacttaacgg 10140

tctttggctt gatgacgtag tttactgtcc aagacatgtg atctgcacct ctgaagacat 10200

gcttaaccct aattatgaag atttactcat tcgtaagtct aatcataatt tcttggtaca 10260

ggctggtaat gttcaactca gggttattgg acattctatg caaaattgtg tacttaagct 10320

taaggttgat acagccaatc ctaagacacc taagtataag tttgttcgca ttcaaccagg 10380

acagactttt tcagtgttag cttgttacaa tggttcacca tctggtgttt accaatgtgc 10440

tatgaggccc aatttcacta ttaagggttc attccttaat ggttcatgtg gtagtgttgg 10500

ttttaacata gattatgact gtgtctcttt ttgttacatg caccatatgg aattaccaac 10560

tggagttcat gctggcacag acttagaagg taacttttat ggaccttttg ttgacaggca 10620

aacagcacaa gcagctggta cggacacaac tattacagtt aatgttttag cttggttgta 10680

cgctgctgtt ataaatggag acaggtggtt tctcaatcga tttaccacaa ctcttaatga 10740

ctttaacctt gtggctatga agtacaatta tgaacctcta acacaagacc atgttgacat 10800

actaggacct ctttctgctc aaactggaat tgccgtttta gatatgtgtg cttcattaaa 10860

agaattactg caaaatggta tgaatggacg taccatattg ggtagtgctt tattagaaga 10920

tgaatttaca ccttttgatg ttgttagaca atgctcaggt gttactttcc aaagtgcagt 10980

gaaaagaaca atcaagggta cacaccactg gttgttactc acaattttga cttcactttt 11040

agttttagtc cagagtactc aatggtcttt gttctttttt ttntatgaaa atgccttttt 11100

accttttgct atgggtatta ttgctatgtc tgcttttgca atgatgtttg tcaaacataa 11160

gcatgcattt ctctgtttgt ttttgttacc ttctcttgcc actgtagctt attttaatat 11220

ggtctatatg cctgctagtt gggtgatgcg tattatgaca tggttggata tggttgatac 11280

tagtttgtct ggttttaagc taaaagactg tgttatgtat gcatcagctg tagtgttact 11340

aatccttatg acagcaagaa ctgtgtatga tgatggtgct aggagagtgt ggacacttat 11400

gaatgtcttg acactcgttt ataaagttta ttatggtaat gctttagatc aagccatttc 11460

catgtgggct cttataatct ctgttacttc taactactca ggtgtagtta caactgtcat 11520

gtttttggcc agaggtattg tttttatgtg tgttgagtat tgccctattt tcttcataac 11580

tggtaataca cttcagtgta taatgctagt ttattgtttc ttaggctatt tttgtacttg 11640

ttactttggc ctcttttgtt tactcaaccg ctactttaga ctgactcttg gtgtttatga 11700

ttacttagtt tctacacagg agtttagata tatgaattca cagggactac tcccacccaa 11760

gaatagcata gatgccttca aactcaacat taaattgttg ggtgttggtg gcaaaccttg 11820

tatcaaagta gccactgtac agtctaaaat gtcagatgta aagtgcacat cagtagtctt 11880

actctcagtt ttgcaacaac tcagagtaga atcatcatct aaattgtggg ctcaatgtgt 11940

ccagttacac aatgacattc tcttagctaa agatactact gaagcctttg aaaaaatggt 12000

ttcactactt tctgttttgc tttccatgca gggtgctgta gacataaaca agctttgtga 12060

agaaatgctg gacaacaggg caaccttaca agctatagcc tcagagttta gttcccttcc 12120

atcatatgca gcttttgcta ctgctcaaga agcttatgag caggctgttg ctaatggtga 12180

ttctgaagtt gttcttaaaa agttgaagaa gtctttgaat gtggctaaat ctgaatttga 12240

ccgtgatgca gccatgcaac gtaagttgga aaagatggct gatcaagcta tgacccaaat 12300

gtataaacag gctagatctg aggacaagag ggcaaaagtt actagtgcta tgcagacaat 12360

gcttttcact atgcttagaa agttggataa tgatgcactc aacaacatta tcaacaatgc 12420

aagagatggt tgtgttccct tgaacataat acctcttaca acagcagcca aactaatggt 12480

tgtcatacca gactataaca catataaaaa tacgtgtgat ggtacaacat ttacttatgc 12540

atcagcattg tgggaaatcc aacaggttgt agatgcagat agtaaaattg ttcaacttag 12600

tgaaattagt atggacaatt cacctaattt agcatggcct cttattgtaa cagctttaag 12660

ggccaattct gctgtcaaat tacagaataa tgagcttagt cctgttgcac tacgacagat 12720

gtcttgtgct gccggtacta cacaaactgc ttgcactgat gacaatgcgt tagcttacta 12780

caacacaaca aagggaggta ggtttgtact tgcactgtta tccgatttac aggatttgaa 12840

atgggctaga ttccctaaga gtgatggaac tggtactatc tatacagaac tggaaccacc 12900

ttgtaggttt gttacagaca cacctaaagg tcctaaagtg aagtatttat actttattaa 12960

aggattaaac aacctaaata gaggtatggt acttggtagt ttagctgcca cagtacgtct 13020

acaagctggt aatgcaacag aagtgcctgc caattcaact gtattatctt tctgtgcttt 13080

tgctgtagat gctgctaaag cttacaaaga ttatctagct agtgggggac aaccaatcac 13140

taattgtgtt aagatgttgt gtacacacac tggtactggt caggcaataa cagttacacc 13200

ggaagccaat atggatcaag aatcctttgg tggtgcatcg tgttgtctgt actgccgttg 13260

ccacatagat catccaaatc ctaaaggatt ttgtgactta aaaggtaagt atgtacaaat 13320

acctacaact tgtgctaatg accctgtggg ttttacactt aaaaacacag tctgtaccgt 13380

ctgcggtatg tggaaaggtt atggctgtag ttgtgatcaa ctccgcgaac ccatgcttca 13440

gtcagctgat gcacaatcgt ttttaaacgg gtttgcggtg taagtgcagc ccgtcttaca 13500

ccgtgcggca caggcactag tactgatgtc gtatacaggg cttttgacat ctacaatgat 13560

aaagtagctg gttttgctaa attcctaaaa actaattgtt gtcgcttcca agaaaaggac 13620

gaagatgaca atttaattga ttcttacttt gtagttaaga gacacacttt ctctaactac 13680

caacatgaag aaacaattta taatttactt aaggattgtc cagctgttgc taaacatgac 13740

ttctttaagt ttagaataga cggtgacatg gtaccacata tatcacgtca acgtcttact 13800

aaatacacaa tggcagacct cgtctatgct ttaaggcatt ttgatgaagg taattgtgac 13860

acattaaaag aaatacttgt cacatacaat tgttgtgatg atgattattt caataaaaag 13920

gactggtatg attttgtaga aaacccagat atattacgcg tatacgccaa cttaggtgaa 13980

cgtgtacgcc aagctttgtt aaaaacagta caattctgtg atgccatgcg aaatgctggt 14040

attgttggtg tactgacatt agataatcaa gatctcaatg gtaactggta tgatttcggt 14100

gatttcatac aaaccacgcc aggtagtgga gttcctgttg tagattctta ttattcattg 14160

ttaatgccta tattaacctt gaccagggct ttaactgcag agtcacatgt tgacactgac 14220

ttaacaaagc cttacattaa gtgggatttg ttaaaatatg acttcacgga agagaggtta 14280

aaactctttg accgttattt taaatattgg gatcagacat accacccaaa ttgtgttaac 14340

tgtttggatg acagatgcat tctgcattgt gcaaacttta atgttttatt ctctacagtg 14400

ttcccaccta caagttttgg accactagtg agaaaaatat ttgttgatgg tgttccattt 14460

gtagtttcaa ctggatacca cttcagagag ctaggtgttg tacataatca ggatgtaaac 14520

ttacatagct ctagacttag ttttaaggaa ttacttgtgt atgctgctga ccctgctatg 14580

cacgctgctt ctggtaatct attactagat aaacgcacta cgtgcttttc agtagctgca 14640

cttactaaca atgttgcttt tcaaactgtc aaacccggta attttaacaa agacttctat 14700

gactttgctg tgtctaaggg tttctttaag gaaggaagtt ctgttgaatt aaaacacttc 14760

ttctttgctc aggatggtaa tgctgctatc agcgattatg actactatcg ttataatcta 14820

ccaacaatgt gtgatatcag acaactacta tttgtagttg aagttgttga taagtacttt 14880

gattgttacg atggtggctg tattaatgct aaccaagtca tcgtcaacaa cctagacaaa 14940

tcagctggtt ttccatttaa taaatggggt aaggctagac tttattatga ttcaatgagt 15000

tatgaggatc aagatgcact tttcgcatat acaaaacgta atgtcatccc tactataact 15060

caaatgaatc ttaagtatgc cattagtgca aagaatagag ctcgcaccgt agctggtgtc 15120

tctatctgta gtactatgac caatagacag tttcatcaaa aattattgaa atcaatagcc 15180

gccactagag gagctactgt agtaattgga acaagcaaat tctatggtgg ttggcacaac 15240

atgttaaaaa ctgtttatag tgatgtagaa aaccctcacc ttatgggttg ggattatcct 15300

aaatgtgata gagccatgcc taacatgctt agaattatgg cctcacttgt tcttgctcgc 15360

aaacatacaa cgtgttgtag cttgtcacac cgtttctata gattagctaa tgagtgtgct 15420

caagtattga gtgaaatggt catgtgtggc ggttcactat atgttaaacc aggtggaacc 15480

tcatcaggag atgccacaac tgcttatgct aatagtgttt ttaacatttg tcaagctgtc 15540

acggccaatg ttaatgcact tttatctact gatggtaaca aaattgccga taagtatgtc 15600

cgcaatttac aacacagact ttatgagtgt ctctatagaa atagagatgt tgacacagac 15660

tttgtgaatg agttttacgc atatttgcgt aaacatttct caatgatgat actctctgac 15720

gatgctgttg tgtgtttcaa tagcacttat gcatctcaag gtctagtggc tagcataaag 15780

aactttaagt cagttcttta ttatcaaaac aatgttttta tgtctgaagc aaaatgttgg 15840

actgagactg accttactaa aggacctcat gaattttgct ctcaacatac aatgctagtt 15900

aaacagggtg atgattatgt gtaccttcct tacccagatc catcaagaat cctaggggcc 15960

ggctgttttg tagatgatat cgtaaaaaca gatggtacac ttatgattga acggttcgtg 16020

tctttagcta tagatgctta cccacttact aaacatccta atcaggagta tgctgatgtc 16080

tttcatttgt acttacaata cataagaaag ctacatgatg agttaacagg acacatgtta 16140

gacatgtatt ctgttatgct tactaatgat aacacttcaa ggtattggga acctgagttt 16200

tatgaggcta tgtacacacc gcatacagtc ttacaggctg ttggggcttg tgttctttgc 16260

aattcacaga cttcattaag atgtggtgct tgcatacgta gaccattctt atgttgtaaa 16320

tgctgttacg accatgtcat atcaacatca cataaattag tcttgtctgt taatccgtat 16380

gtttgcaatg ctccaggttg tgatgtcaca gatgtgactc aactttactt aggaggtatg 16440

agctattatt gtaaatcaca taaaccaccc attagttttc cattgtgtgc taatggacaa 16500

gtttttggtt tatataaaaa tacatgtgtt ggtagcgata atgttactga ctttaatgca 16560

attgcaacat gtgactggac aaatgctggt gattacattt tagctaacac ctgtactgaa 16620

agactcaagc tttttgcagc agaaacgctc aaagctactg aggagacatt taaactgtct 16680

tatggtattg ctactgtacg tgaagtgctg tctgacagag aattacatct ttcatgggaa 16740

gttggtaaac ctagaccacc acttaaccga aattatgtct ttactggtta tcgtgtaact 16800

aaaaacagta aagtacaaat aggagagtac acctttgaaa aaggtgacta tggtgatgct 16860

gttgtttacc gaggtacaac aacttacaaa ttaaatgttg gtgattattt tgtgctgaca 16920

tcacatacag taatgccatt aagtgcacct acactagtgc cacaagagca ctatgttaga 16980

attactggct tatacccaac actcaatatc tcagatgagt tttctagcaa tgttgcaaat 17040

tatcaaaagg ttggtatgca aaagtattct acactccagg gaccacctgg tactggtaag 17100

agtcattttg ctattggcct agctctctac tacccttctg ctcgcatagt gtatacagct 17160

tgctctcatg ccgctgttga tgcactatgt gagaaggcat taaaatattt gcctatagat 17220

aaatgtagta gaattatacc tgcacgtgct cgtgtagagt gttttgataa attcaaagtg 17280

aattcaacat tagaacagta tgtcttttgt actgtaaatg cattgcctga gacgacagca 17340

gatatagttg tctttgatga aatttcaatg gccacaaatt atgatttgag tgttgtcaat 17400

gccagattac gtgctaagca ctatgtgtac attggcgacc ctgctcaatt acctgcacca 17460

cgcacattgc taactaaggg cacactagaa ccagaatatt tcaattcagt gtgtagactt 17520

atgaaaacta taggtccaga catgttcctc ggaacttgtc ggcgttgtcc tgctgaaatt 17580

gttgacactg tgagtgcttt ggtttatgat aataagctta aagcacataa agacaaatca 17640

gctcaatgct ttaaaatgtt ttataagggt gttatcacgc atgatgtttc atctgcaatt 17700

aacaggccac aaataggcgt ggtaagagaa ttccttacac gtaaccctgc ttggagaaaa 17760

gctgtcttta tttcacctta taattcacag aatgctgtag cctcaaagat tttgggacta 17820

ccaactcaaa ctgttgattc atcacagggc tcagaatatg actatgtcat attcactcaa 17880

accactgaaa cagctcactc ttgtaatgta aacagattta atgttgctat taccagagca 17940

aaagtaggca tactttgcat aatgtctgat agagaccttt atgacaagtt gcaatttaca 18000

agtcttgaaa ttccacgtag gaatgtggca actttacaag ctgaaaatgt aacaggactc 18060

tttaaagatt gtagtaaggt aatcactggg ttacatccta cacaggcacc tacacacctc 18120

agtgttgaca ctaaattcaa aactgaaggt ttatgtgttg acatacctgg catacctaag 18180

gacatgacct atagaagact catctctatg atgggtttta aaatgaatta tcaagttaat 18240

ggttacccta acatgtttat cacccgcgaa gaagctataa gacatgtacg tgcatggatt 18300

ggcttcgatg tcgaggggtg tcatgctact agagaagctg ttggtaccaa tttaccttta 18360

cagctaggtt tttctacagg tgttaaccta gttgctgtac ctacaggtta tgttgataca 18420

cctaataata cagatttttc cagagttagt gctaaaccac cgcctggaga tcaatttaaa 18480

cacctcatac cacttatgta caaaggactt ccttggaatg tagtgcgtat aaagattgta 18540

caaatgttaa gtgacacact taaaaatctc tctgacagag tcgtatttgt cttatgggca 18600

catggctttg agttgacatc tatgaagtat tttgtgaaaa taggacctga gcgcacctgt 18660

tgtctatgtg atagacgtgc cacatgcttt tccactgctt cagacactta tgcctgttgg 18720

catcattcta ttggatttga ttacgtctat aatccgttta tgattgatgt tcaacaatgg 18780

ggttttacag gtaacctaca aagcaaccat gatctgtatt gtcaagtcca tggtaatgca 18840

catgtagcta gttgtgatgc aatcatgact aggtgtctag ctgtccacga gtgctttgtt 18900

aagcgtgttg actggactat tgaatatcct ataattggtg atgaactgaa gattaatgcg 18960

gcttgtagaa aggttcaaca catggttgtt aaagctgcat tattagcaga caaattccca 19020

gttcttcacg acattggtaa ccctaaagct attaagtgtg tacctcaagc tgatgtagaa 19080

tggaagttct atgatgcaca gccttgtagt gacaaagctt ataaaataga agaattattc 19140

tattcttatg ccacacattc tgacaaattc acagatggtg tatgcctatt ttggaattgc 19200

aatgtcgata gatatcctgc taattccatt gtttgtagat ttgacactag agtgctatct 19260

aaccttaact tgcctggttg tgatggtggc agtttgtatg taaataaaca tgcattccac 19320

acaccagctt ttgataaaag tgcttttgtt aatttaaaac aattaccatt tttctattac 19380

tctgacagtc catgtgagtc tcatggaaaa caagtagtgt cagatataga ttatgtacca 19440

ctaaagtctg ctacgtgtat aacacgttgc aatttaggtg gtgctgtctg tagacatcat 19500

gctaatgagt acagattgta tctcgatgct tataacatga tgatctcagc tggctttagc 19560

ttgtgggttt acaaacaatt tgatacttat aacctctgga acacttttac aagacttcag 19620

agtttagaaa atgtggcttt taatgttgta aataagggac actttgatgg acaacagggt 19680

gaagtaccag tttctatcat taataacact gtttacacaa aagttgatgg tgttgatgta 19740

gaattgtttg aaaataaaac aacattacct gttaatgtag catttgagct ttgggctaag 19800

cgcaacatta aaccagtacc agaggtgaaa atactcaata atttgggtgt ggacattgct 19860

gctaatactg tgatctggga ctacaaaaga gatgctccag cacatatatc tactattggt 19920

gtttgttcta tgactgacat agccaagaaa ccaactgaaa cgatttgtgc accactcact 19980

gtcttttttg atggtagagt tgatggtcaa gtagacttat ttagaaatgc ccgtaatggt 20040

gttcttatta cagaaggtag tgttaaaggt ttacaaccat ctgtaggtcc caaacaagct 20100

agtcttaatg gagtcacatt aattggagaa gccgtaaaaa cacagttcaa ttattataag 20160

aaagttgatg gtgttgtcca acaattacct gaaacttact ttactcagag tagaaattta 20220

caagaattta aacccaggag tcaaatggaa attgatttct tagaattagc tatggatgaa 20280

ttcattgaac ggtataaatt agaaggctat gccttcgaac atatcgttta tggagatttt 20340

agtcatagtc agttaggtgg tttacatcta ctgattggac tagctaaacg ttttaaggaa 20400

tcaccttttg aattagaaga ttttattcct atggacagta cagttaaaaa ctatttcata 20460

acagatgcgc aaacaggttc atctaagtgt gtgtgttctg ttattgattt attacttgat 20520

gattttgttg aaataataaa atcccaagat ttatctgtag tttctaaggt tgtcaaagtg 20580

actattgact atacagaaat ttcatttatg ctttggtgta aagatggcca tgtagaaaca 20640

ttttacccaa aattacaatc tagtcaagcg tggcaaccgg gtgttgctat gcctaatctt 20700

tacaaaatgc aaagaatgct attagaaaag tgtgaccttc aaaattatgg tgatagtgca 20760

acattaccta aaggcataat gatgaatgtc gcaaaatata ctcaactgtg tcaatattta 20820

aacacattaa cattagctgt accctataat atgagagtta tacattttgg tgctggttct 20880

gataaaggag ttgcaccagg tacagctgtt ttaagacagt ggttgcctac gggtacgctg 20940

cttgtcgatt cagatcttaa tgactttgtc tctgatgcag attcaacttt gattggtgat 21000

tgtgcaactg tacatacagc taataaatgg gatctcatta ttagtgatat gtacgaccct 21060

aagactaaaa atgttacaaa agaaaatgac tctaaagagg gttttttcac ttacatttgt 21120

gggtttatac aacaaaagct agctcttgga ggttccgtgg ctataaagat aacagaacat 21180

tcttggaatg ctgatcttta taagctcatg ggacacttcg catggtggac agcctttgtt 21240

actaatgtga atgcgtcatc atctgaagca tttttaattg gatgtaatta tcttggcaaa 21300

ccacgcgaac aaatagatgg ttatgtcatg catgcaaatt acatattttg gaggaataca 21360

aatccaattc agttgtcttc ctattcttta tttgacatga gtaaatttcc ccttaaatta 21420

aggggtactg ctgttatgtc tttaaaagaa ggtcaaatca atgatatgat tttatctctt 21480

cttagtaaag gtagacttat aattagagaa aacaacagag ttgttatttc tagtgatgtt 21540

cttgttaaca actaaacgaa caatgtttgt ttttcttgtt ttattgccac tagtctctag 21600

tcagtgtgtt aatcttacaa ccagaactca attaccccct gcatacacta attctttcac 21660

acgtggtgtt tattaccctg acaaagtttt cagatcctca gttttacatt caactcagga 21720

cttgttctta cctttctttt ccaatgttac ttggttccat gctatacatg tctctgggac 21780

caatggtact aagaggtttg ataaccctgt cctaccattt aatgatggtg tttattttgc 21840

ttccactgag aagtctaaca taataagagg ctggattttt ggtactactt tagattcgaa 21900

gacccagtcc ctacttattg ttaataacgc tactaatgtt gttattaaag tctgtgaatt 21960

tcaattttgt aatgatccat ttttgggtgt ttattaccac aaaaacaaca aaagttggat 22020

ggaaagtgag ttcagagttt attctagtgc gaataattgc acttttgaat atgtctctca 22080

gccttttctt atggaccttg aaggaaaaca gggtaatttc aaaaatctta gggaatttgt 22140

gtttaagaat attgatggtt attttaaaat atattctaag cacacgccta ttaatttagt 22200

gcgtgatctc cctcagggtt tttcggcttt agaaccattg gtagatttgc caataggtat 22260

taacatcact aggtttcaaa ctttacttgc tttacataga agttatttga ctcctggtga 22320

ttcttcttca ggttggacag ctggtgctgc agcttattat gtgggttatc ttcaacctag 22380

gacttttcta ttaaaatata atgaaaatgg aaccattaca gatgctgtag actgtgcact 22440

tgaccctctc tcagaaacaa agtgtacgtt gaaatccttc actgtagaaa aaggaatcta 22500

tcaaacttct aactttagag tccaaccaac agaatctatt gttagatttc ctaatattac 22560

aaacttgtgc ccttttggtg aagtttttaa cgccaccaga tttgcatctg tttatgcttg 22620

gaacaggaag agaatcagca actgtgttgc tgattattct gtcctatata attccgcatc 22680

attttccact tttaagtgtt atggagtgtc tcctactaaa ttaaatgatc tctgctttac 22740

taatgtctat gcagattcat ttgtaattag aggtgatgaa gtcagacaaa tcgctccagg 22800

gcaaactgga aagattgctg attataatta taaattacca gatgatttta caggctgcgt 22860

tatagcttgg aattctaaca atcttgattc taaggttggt ggtaattata attacctgta 22920

tagattgttt aggaagtcta atctcaaacc ttttgagaga gatatttcaa ctgaaatcta 22980

tcaggccggt agcacacctt gtaatggtgt tgaaggtttt aattgttact ttcctttaca 23040

atcatatggt ttccaaccca ctaatggtgt tggttaccaa ccatacagag tagtagtact 23100

ttcttttgaa cttctacatg caccagcaac tgtttgtgga cctaaaaagt ctactaattt 23160

ggttaaaaac aaatgtgtca atttcaactt caatggttta acaggcacag gtgttcttac 23220

tgagtctaac aaaaagtttc tgcctttcca acaatttggc agagacattg ctgacactac 23280

tgatgctgtc cgtgatccac agacacttga gattcttgac attacaccat gttcttttgg 23340

tggtgtcagt gttataacac caggaacaaa tacttctaac caggttgctg ttctttatca 23400

ggatgttaac tgcacagaag tccctgttgc tattcatgca gatcaactta ctcctacttg 23460

gcgtgtttat tctacaggtt ctaatgtttt tcaaacacgt gcaggctgtt taataggggc 23520

tgaacatgtc aacaactcat atgagtgtga catacccatt ggtgcaggta tatgcgctag 23580

ttatcagact cagactaatt ctcctcggcg ggcacgtagt gtagctagtc aatccatcat 23640

tgcctacact atgtcacttg gtgcagaaaa ttcagttgct tactctaata actctattgc 23700

catacccaca aattttacta ttagtgttac cacagaaatt ctaccagtgt ctatgaccaa 23760

gacatcagta gattgtacaa tgtacatttg tggtgattca actgaatgca gcaatctttt 23820

gttgcaatat ggcagttttt gtacacaatt aaaccgtgct ttaactggaa tagctgttga 23880

acaagacaaa aacacccaag aagtttttgc acaagtcaaa caaatttaca aaacaccacc 23940

aattaaagat tttggtggtt ttaatttttc acaaatatta ccagatccat caaaaccaag 24000

caagaggtca tttattgaag atctactttt caacaaagtg acacttgcag atgctggctt 24060

catcaaacaa tatggtgatt gccttggtga tattgctgct agagacctca tttgtgcaca 24120

aaagtttaac ggccttactg ttttgccacc tttgctcaca gatgaaatga ttgctcaata 24180

cacttctgca ctgttagcgg gtacaatcac ttctggttgg acctttggtg caggtgctgc 24240

attacaaata ccatttgcta tgcaaatggc ttataggttt aatggtattg gagttacaca 24300

gaatgttctc tatgagaacc aaaaattgat tgccaaccaa tttaatagtg ctattggcaa 24360

aattcaagac tcactttctt ccacagcaag tgcacttgga aaacttcaag atgtggtcaa 24420

ccaaaatgca caagctttaa acacgcttgt taaacaactt agctccaatt ttggtgcaat 24480

ttcaagtgtt ttaaatgata tcctttcacg tcttgacaaa gttgaggctg aagtgcaaat 24540

tgataggttg atcacaggca gacttcaaag tttgcagaca tatgtgactc aacaattaat 24600

tagagctgca gaaatcagag cttctgctaa tcttgctgct actaaaatgt cagagtgtgt 24660

acttggacaa tcaaaaagag ttgatttttg tggaaagggc tatcatctta tgtccttccc 24720

tcagtcagca cctcatggtg tagtcttctt gcatgtgact tatgtccctg cacaagaaaa 24780

gaacttcaca actgctcctg ccatttgtca tgatggaaaa gcacactttc ctcgtgaagg 24840

tgtctttgtt tcaaatggca cacactggtt tgtaacacaa aggaattttt atgaaccaca 24900

aatcattact acagacaaca catttgtgtc tggtaactgt gatgttgtaa taggaattgt 24960

caacaacaca gtttatgatc ctttgcaacc tgaattagac tcattcaagg aggagttaga 25020

taaatatttt aagaatcata catcaccaga tgttgattta ggtgacatct ctggcattaa 25080

tgcttcagtt gtaaacattc aaaaagaaat tgaccgcctc aatgaggttg ccaagaattt 25140

aaatgaatct ctcatcgatc tccaagaact tggaaagtat gagcagtata taaaatggcc 25200

atggtacatt tggctaggtt ttatagctgg cttgattgcc atagtaatgg tgacaattat 25260

gctttgctgt atgaccagtt gctgtagttg tctcaagggc tgttgttctt gtggatcctg 25320

ctgcaaattt gatgaagacg actctgagcc agtgctcaaa ggagtcaaat tacattacac 25380

ataaacgaac ttatggattt gtttatgaga atcttcacaa ttggaactgt aactttgaag 25440

caaggtgaaa tcaaggatgc tactccttca gattttgttc gcgctactgc aacgataccg 25500

atacaagcct cactcccttt cggatggctt attgttggcg ttgcacttct tgctgttttt 25560

cagagcgctt ccaaaatcat aaccctcaaa aagagatggc aactagcact ctccaagggt 25620

gttcactttg tttgcaactt gctgttgttg tttgtaacag tttactcaca ccttttgctc 25680

gttgctgctg gccttgaagc cccttttctc tatctttatg ctttagtcta cttcttgcag 25740

agtataaact ttgtaagaat aataatgagg ctttggcttt gctggaaatg ccgttccaaa 25800

aacccattac tttatgatgc caactatttt ctttgctggc atactaattg ttacgactat 25860

tgtatacctt acaatagtgt aacttcttca attgtcatta cttcaggtga tggcacaaca 25920

agtcctattt ctgaacatga ctaccagatt ggtggttata ctgaaaaatg ggaatctgga 25980

gtaaaagact gtgttgtatt acacagttac ttcacttcag actattacca gctgtactca 26040

actcaattga gtacagacac tggtgttgaa catgttacct tcttcatcta caataaaatt 26100

gttgatgagc ctgaagaaca tgtccaaatt cacacaatcg acgtttcatc cggagttgtt 26160

aatccagtaa tggaaccaat ttatgatgaa ccgacgacga ctactagcgt gcctttgtaa 26220

gcacaagctg atgagtacga acttatgtac tcattcgttt cggaagagac aggtacgtta 26280

atagttaata gcgtacttct ttttcttgct ttcgtggtat tcttgctagt tacactagcc 26340

atccttactg cgcttcgatt gtgtgcgtac tgctgcaata ttgttaacgt gagtcttgta 26400

aaaccttctt tttacgttta ctctcgtgtt aaaaatctga attcttctag agttcctgat 26460

cttctggtct aaacgaacta aatattatat tagtttttct gtttggaact ttaattttag 26520

ccatggcaga ttccaacggt actattaccg ttgaagagct taaaaagctc cttgaacaat 26580

ggaacctagt aataggtttc ctattcctta catggatttg tcttctacaa tttgcctatg 26640

ccaacaggaa taggtttttg tatataatta agttaatttt cctctggctg ttatggccag 26700

taactttagc ttgttttgtg cttgctgctg tttacagaat aaattggatc accggtggaa 26760

ttgctatcgc aatggcttgt cttgtaggct tgatgtggct cagctacttc attgcttctt 26820

tcagactgtt tgcgcgtacg cgttccatgt ggtcattcaa tccagaaact aacattcttc 26880

tcaacgtgcc actccatggc actattctga ccagaccgct tctagaaagt gaactcgtaa 26940

tcggagctgt gatccttcgt ggacatcttc gtattgctgg acaccatcta ggacgctgtg 27000

acatcaagga cctgcctaaa gaaatcactg ttgctacatc acgaacgctt tcttattaca 27060

aattgggagc ttcgcagcgt gtagcaggtg actcaggttt tgctgcatac agtcgctaca 27120

ggattggcaa ctataaatta aacacagacc attccagtag cagtgacaat attgctttgc 27180

ttgtacagta agtgacaaca gatgtttcat ctcgttgact ttcaggttac tatagcagag 27240

atattactaa ttattatgag gacttttaaa gtttccattt ggaatcttga ttacatcata 27300

aacctcataa ttaaaaattt atctaagtca ctaactgaga ataaatattc tcaattagat 27360

gaagagcaac caatggagat tgattaaacg aacatgaaaa ttattctttt cttggcactg 27420

ataacactcg ctacttgtga gctttatcac taccaagagt gtgttagagg tacaacagta 27480

cttttaaaag aaccttgctc ttctggaaca tacgagggca attcaccatt tcatcctcta 27540

gctgataaca aatttgcact gacttgcttt agcactcaat ttgcttttgc ttgtcctgac 27600

ggcgtaaaac acgtctatca gttacgtgcc agatcagttt cacctaaact gttcatcaga 27660

caagaggaag ttcaagaact ttactctcca atttttctta ttgttgcggc aatagtgttt 27720

ataacacttt gcttcacact caaaagaaag acagaatgat tgaactttca ttaattgact 27780

tctatttgtg ctttttagcc tttctgctat tccttgtttt aattatgctt attatctttt 27840

ggttctcact tgaactgcaa gatcataatg aaacttgtca cgcctaaacg aacatgaaat 27900

ttcttgtttt cttaggaatc atcacaactg tagctgcatt tcaccaagaa tgtagtttac 27960

agtcatgtac tcaacatcaa ccatatgtag ttgatgaccc gtgtcctatt cacttctatt 28020

ctaaatggta tattagagta ggagctagaa aatcagcacc tttaattgaa ttgtgcgtgg 28080

atgaggctgg ttctaaatca cccattcagt acatcgatat cggtaattat acagtttcct 28140

gtttaccttt tacaattaat tgccaggaac ctaaattggg tagtcttgta gtgcgttgtt 28200

cgttctatga agacttttta gagtatcatg acgttcgtgt tgttttagat ttcatctaaa 28260

cgaacaaact aaaatgtctg ataatggacc ccaaaatcag cgaaatgcac cccgcattac 28320

gtttggtgga ccctcagatt caactggcag taaccagaat ggagaacgca gtggggcgcg 28380

atcaaaacaa cgtcggcccc aaggtttacc caataatact gcgtcttggt tcaccgctct 28440

cactcaacat ggcaaggaag accttaaatt ccctcgagga caaggcgttc caattaacac 28500

caatagcagt ccagatgacc aaattggcta ctaccgaaga gctaccagac gaattcgtgg 28560

tggtgacggt aaaatgaaag atctcagtcc aagatggtat ttctactacc taggaactgg 28620

gccagaagct ggacttccct atggtgctaa caaagacggc atcatatggg ttgcaactga 28680

gggagccttg aatacaccaa aagatcacat tggcacccgc aatcctgcta acaatgctgc 28740

aatcgtgcta caacttcctc aaggaacaac attgccaaaa ggcttctacg cagaagggag 28800

cagaggcggc agtcaagcct cttctcgttc ctcatcacgt agtcgcaaca gttcaagaaa 28860

ttcaactcca ggcagcagta ggggaacttc tcctgctaga atggctggca atggcggtga 28920

tgctgctctt gctttgctgc tgcttgacag attgaaccag cttgagagca aaatgtctgg 28980

taaaggccaa caacaacaag gccaaactgt cactaagaaa tctgctgctg aggcttctaa 29040

gaagcctcgg caaaaacgta ctgccactaa agcatacaat gtaacacaag ctttcggcag 29100

acgtggtcca gaacaaaccc aaggaaattt tggggaccag gaactaatca gacaaggaac 29160

tgattacaaa cattggccgc aaattgcaca atttgccccc agcgcttcag cgttcttcgg 29220

aatgtcgcgc attggcatgg aagtcacacc ttcgggaacg tggttgacct acacaggtgc 29280

catcaaattg gatgacaaag atccaaattt caaagatcaa gtcattttgc tgaataagca 29340

tattgacgca tacaaaacat tcccaccaac agagcctaaa aaggacaaaa agaagaaggc 29400

tgatgaaact caagccttac cgcagagaca gaagaaacag caaactgtga ctcttcttcc 29460

tgctgcagat ttggatgatt tctccaaaca attgcaacaa tccatgagca gtgctgactc 29520

aactcaggcc taaactcatg cagaccacac aaggcagatg ggctatataa acgttttcgc 29580

ttttccgttt acgatatata gtctactctt gtgcagaatg aattctcgta actacatagc 29640

acaagtagat gtagttaact ttaatctcac atagcaatct ttaatcagtg tgtaacatta 29700

gggaggactt gaaagagcca ccacattttc accgaggcca cgcggagtac gatcgagtgt 29760

acagtgaaca atgctaggga gagctgccta tatggaagag ccctaatgtg taaaattaat 29820

tttagtagtg ctatccccat gtgattttaa tagcttctta ggagaat 29867

<210> 10

<211> 7062

<212> PRT

<213> SARS-CoV2

<220>

<221> UNSURE

<222> (3606)..(3606)

<223> Xaa can be any naturally occurring amino acid (Xaa can any naturally curing amino acid)

<400> 10

Met Glu Ser Leu Val Pro Gly Phe Asn Glu Lys Thr His Val Gln Leu

1 5 10 15

Ser Leu Pro Val Leu Gln Val Arg Asp Val Leu Val Arg Gly Phe Gly

20 25 30

Asp Ser Val Glu Glu Val Leu Ser Glu Ala Arg Gln His Leu Lys Asp

35 40 45

Gly Thr Cys Gly Leu Val Glu Val Glu Lys Gly Val Leu Pro Gln Leu

50 55 60

Glu Gln Pro Tyr Val Phe Ile Lys Arg Ser Asp Ala Arg Thr Ala Pro

65 70 75 80

His Gly His Val Met Val Glu Leu Val Ala Glu Leu Glu Gly Ile Gln

85 90 95

Tyr Gly Arg Ser Gly Glu Thr Leu Gly Val Leu Val Pro His Val Gly

100 105 110

Glu Ile Pro Val Ala Tyr Arg Lys Val Leu Leu Arg Lys Asn Gly Asn

115 120 125

Lys Gly Ala Gly Gly His Ser Tyr Gly Ala Asp Leu Lys Ser Phe Asp

130 135 140

Leu Gly Asp Glu Leu Gly Thr Asp Pro Tyr Glu Asp Phe Gln Glu Asn

145 150 155 160

Trp Asn Thr Lys His Ser Ser Gly Val Thr Arg Glu Leu Met Arg Glu

165 170 175

Leu Asn Gly Gly Ala Tyr Thr Arg Tyr Val Asp Asn Asn Phe Cys Gly

180 185 190

Pro Asp Gly Tyr Pro Leu Glu Cys Ile Lys Asp Leu Leu Ala Arg Ala

195 200 205

Gly Lys Ala Ser Cys Thr Leu Ser Glu Gln Leu Asp Phe Ile Asp Thr

210 215 220

Lys Arg Gly Val Tyr Cys Cys Arg Glu His Glu His Glu Ile Ala Trp

225 230 235 240

Tyr Thr Glu Arg Ser Glu Lys Ser Tyr Glu Leu Gln Thr Pro Phe Glu

245 250 255

Ile Lys Leu Ala Lys Lys Phe Asp Thr Phe Asn Gly Glu Cys Pro Asn

260 265 270

Phe Val Phe Pro Leu Asn Ser Ile Ile Lys Thr Ile Gln Pro Arg Val

275 280 285

Glu Lys Lys Lys Leu Asp Gly Phe Met Gly Arg Ile Arg Ser Val Tyr

290 295 300

Pro Val Ala Ser Pro Asn Glu Cys Asn Gln Met Cys Leu Ser Thr Leu

305 310 315 320

Met Lys Cys Asp His Cys Gly Glu Thr Ser Trp Gln Thr Gly Asp Phe

325 330 335

Val Lys Ala Thr Cys Glu Phe Cys Gly Thr Glu Asn Leu Thr Lys Glu

340 345 350

Gly Ala Thr Thr Cys Gly Tyr Leu Pro Gln Asn Ala Val Val Lys Ile

355 360 365

Tyr Cys Pro Ala Cys His Asn Ser Glu Val Gly Pro Glu His Ser Leu

370 375 380

Ala Glu Tyr His Asn Glu Ser Gly Leu Lys Thr Ile Leu Arg Lys Gly

385 390 395 400

Gly Arg Thr Ile Ala Phe Gly Gly Cys Val Phe Ser Tyr Val Gly Cys

405 410 415

His Asn Lys Cys Ala Tyr Trp Val Pro Arg Ala Ser Ala Asn Ile Gly

420 425 430

Cys Asn His Thr Gly Val Val Gly Glu Gly Ser Glu Gly Leu Asn Asp

435 440 445

Asn Leu Leu Glu Ile Leu Gln Lys Glu Lys Val Asn Ile Asn Ile Val

450 455 460

Gly Asp Phe Lys Leu Asn Glu Glu Ile Ala Ile Ile Leu Ala Ser Phe

465 470 475 480

Ser Ala Ser Thr Ser Ala Phe Val Glu Thr Val Lys Gly Leu Asp Tyr

485 490 495

Lys Ala Phe Lys Gln Ile Val Glu Ser Cys Gly Asn Phe Lys Val Thr

500 505 510

Lys Gly Lys Ala Lys Lys Gly Ala Trp Asn Ile Gly Glu Gln Lys Ser

515 520 525

Ile Leu Ser Pro Leu Tyr Ala Phe Ala Ser Glu Ala Ala Arg Val Val

530 535 540

Arg Ser Ile Phe Ser Arg Thr Leu Glu Thr Ala Gln Asn Ser Val Arg

545 550 555 560

Val Leu Gln Lys Ala Ala Ile Thr Ile Leu Asp Gly Ile Ser Gln Tyr

565 570 575

Ser Leu Arg Leu Ile Asp Ala Met Met Phe Thr Ser Asp Leu Ala Thr

580 585 590

Asn Asn Leu Val Val Met Ala Tyr Ile Thr Gly Gly Val Val Gln Leu

595 600 605

Thr Ser Gln Trp Leu Thr Asn Ile Phe Gly Thr Val Tyr Glu Lys Leu

610 615 620

Lys Pro Val Leu Asp Trp Leu Glu Glu Lys Phe Lys Glu Gly Val Glu

625 630 635 640

Phe Leu Arg Asp Gly Trp Glu Ile Val Lys Phe Ile Ser Thr Cys Ala

645 650 655

Cys Glu Ile Val Gly Gly Gln Ile Val Thr Cys Ala Lys Glu Ile Lys

660 665 670

Glu Ser Val Gln Thr Phe Phe Lys Leu Val Asn Lys Phe Leu Ala Leu

675 680 685

Cys Ala Asp Ser Ile Ile Ile Gly Gly Ala Lys Leu Lys Ala Leu Asn

690 695 700

Leu Gly Glu Thr Phe Val Thr His Ser Lys Gly Leu Tyr Arg Lys Cys

705 710 715 720

Val Lys Ser Arg Glu Glu Thr Gly Leu Leu Met Pro Leu Lys Ala Pro

725 730 735

Lys Glu Ile Ile Phe Leu Glu Gly Glu Thr Leu Pro Thr Glu Val Leu

740 745 750

Thr Glu Glu Val Val Leu Lys Thr Gly Asp Leu Gln Pro Leu Glu Gln

755 760 765

Pro Thr Ser Glu Ala Val Glu Ala Pro Leu Val Gly Thr Pro Val Cys

770 775 780

Ile Asn Gly Leu Met Leu Leu Glu Ile Lys Asp Thr Glu Lys Tyr Cys

785 790 795 800

Ala Leu Ala Pro Asn Met Met Val Thr Asn Asn Thr Phe Thr Leu Lys

805 810 815

Gly Gly Ala Pro Thr Lys Val Thr Phe Gly Asp Asp Thr Val Ile Glu

820 825 830

Val Gln Gly Tyr Lys Ser Val Asn Ile Thr Phe Glu Leu Asp Glu Arg

835 840 845

Ile Asp Lys Val Leu Asn Glu Lys Cys Ser Ala Tyr Thr Val Glu Leu

850 855 860

Gly Thr Glu Val Asn Glu Phe Ala Cys Val Val Ala Asp Ala Val Ile

865 870 875 880

Lys Thr Leu Gln Pro Val Ser Glu Leu Leu Thr Pro Leu Gly Ile Asp

885 890 895

Leu Asp Glu Trp Ser Met Ala Thr Tyr Tyr Leu Phe Asp Glu Ser Gly

900 905 910

Glu Phe Lys Leu Ala Ser His Met Tyr Cys Ser Phe Tyr Pro Pro Asp

915 920 925

Glu Asp Glu Glu Glu Gly Asp Cys Glu Glu Glu Glu Phe Glu Pro Ser

930 935 940

Thr Gln Tyr Glu Tyr Gly Thr Glu Asp Asp Tyr Gln Gly Lys Pro Leu

945 950 955 960

Glu Phe Gly Ala Thr Ser Ala Ala Leu Gln Pro Glu Glu Glu Gln Glu

965 970 975

Glu Asp Trp Leu Asp Asp Asp Ser Gln Gln Thr Val Gly Gln Gln Asp

980 985 990

Gly Ser Glu Asp Asn Gln Thr Thr Thr Ile Gln Thr Ile Val Glu Val

995 1000 1005

Gln Pro Gln Leu Glu Met Glu Leu Thr Pro Val Val Gln Thr Ile

1010 1015 1020

Glu Val Asn Ser Phe Ser Gly Tyr Leu Lys Leu Thr Asp Asn Val

1025 1030 1035

Tyr Ile Lys Asn Ala Asp Ile Val Glu Glu Ala Lys Lys Val Lys

1040 1045 1050

Pro Thr Val Val Val Asn Ala Ala Asn Val Tyr Leu Lys His Gly

1055 1060 1065

Gly Gly Val Ala Gly Ala Leu Asn Lys Ala Thr Asn Asn Ala Met

1070 1075 1080

Gln Val Glu Ser Asp Asp Tyr Ile Ala Thr Asn Gly Pro Leu Lys

1085 1090 1095

Val Gly Gly Ser Cys Val Leu Ser Gly His Asn Leu Ala Lys His

1100 1105 1110

Cys Leu His Val Val Gly Pro Asn Val Asn Lys Gly Glu Asp Ile

1115 1120 1125

Gln Leu Leu Lys Ser Ala Tyr Glu Asn Phe Asn Gln His Glu Val

1130 1135 1140

Leu Leu Ala Pro Leu Leu Ser Ala Gly Ile Phe Gly Ala Asp Pro

1145 1150 1155

Ile His Ser Leu Arg Val Cys Val Asp Thr Val Arg Thr Asn Val

1160 1165 1170

Tyr Leu Ala Val Phe Asp Lys Asn Leu Tyr Asp Lys Leu Val Ser

1175 1180 1185

Ser Phe Leu Glu Met Lys Ser Glu Lys Gln Val Glu Gln Lys Ile

1190 1195 1200

Ala Glu Ile Pro Lys Glu Glu Val Lys Pro Phe Ile Thr Glu Ser

1205 1210 1215

Lys Pro Ser Val Glu Gln Arg Lys Gln Asp Asp Lys Lys Ile Lys

1220 1225 1230

Ala Cys Val Glu Glu Val Thr Thr Thr Leu Glu Glu Thr Lys Phe

1235 1240 1245

Leu Thr Glu Asn Leu Leu Leu Tyr Ile Asp Ile Asn Gly Asn Leu

1250 1255 1260

His Pro Asp Ser Ala Thr Leu Val Ser Asp Ile Asp Ile Thr Phe

1265 1270 1275

Leu Lys Lys Asp Ala Pro Tyr Ile Val Gly Asp Val Val Gln Glu

1280 1285 1290

Gly Val Leu Thr Ala Val Val Ile Pro Thr Lys Lys Ala Gly Gly

1295 1300 1305

Thr Thr Glu Met Leu Ala Lys Ala Leu Arg Lys Val Pro Thr Asp

1310 1315 1320

Asn Tyr Ile Thr Thr Tyr Pro Gly Gln Gly Leu Asn Gly Tyr Thr

1325 1330 1335

Val Glu Glu Ala Lys Thr Val Leu Lys Lys Cys Lys Ser Ala Phe

1340 1345 1350

Tyr Ile Leu Pro Ser Ile Ile Ser Asn Glu Lys Gln Glu Ile Leu

1355 1360 1365

Gly Thr Val Ser Trp Asn Leu Arg Glu Met Leu Ala His Ala Glu

1370 1375 1380

Glu Thr Arg Lys Leu Met Pro Val Cys Val Glu Thr Lys Ala Ile

1385 1390 1395

Val Ser Thr Ile Gln Arg Lys Tyr Lys Gly Ile Lys Ile Gln Glu

1400 1405 1410

Gly Val Val Asp Tyr Gly Ala Arg Phe Tyr Phe Tyr Thr Ser Lys

1415 1420 1425

Thr Thr Val Ala Ser Leu Ile Asn Thr Leu Asn Asp Leu Asn Glu

1430 1435 1440

Thr Leu Val Thr Met Pro Leu Gly Tyr Val Thr His Gly Leu Asn

1445 1450 1455

Leu Glu Glu Ala Ala Arg Tyr Met Arg Ser Leu Lys Val Pro Ala

1460 1465 1470

Thr Val Ser Val Ser Ser Pro Asp Ala Val Thr Ala Tyr Asn Gly

1475 1480 1485

Tyr Leu Thr Ser Ser Ser Lys Thr Pro Glu Glu His Phe Ile Glu

1490 1495 1500

Thr Ile Ser Leu Ala Gly Ser Tyr Lys Asp Trp Ser Tyr Ser Gly

1505 1510 1515

Gln Ser Thr Gln Leu Gly Ile Glu Phe Leu Lys Arg Gly Asp Lys

1520 1525 1530

Ser Val Tyr Tyr Thr Ser Asn Pro Thr Thr Phe His Leu Asp Gly

1535 1540 1545

Glu Val Ile Thr Phe Asp Asn Leu Lys Thr Leu Leu Ser Leu Arg

1550 1555 1560

Glu Val Arg Thr Ile Lys Val Phe Thr Thr Val Asp Asn Ile Asn

1565 1570 1575

Leu His Thr Gln Val Val Asp Met Ser Met Thr Tyr Gly Gln Gln

1580 1585 1590

Phe Gly Pro Thr Tyr Leu Asp Gly Ala Asp Val Thr Lys Ile Lys

1595 1600 1605

Pro His Asn Ser His Glu Gly Lys Thr Phe Tyr Val Leu Pro Asn

1610 1615 1620

Asp Asp Thr Leu Arg Val Glu Ala Phe Glu Tyr Tyr His Thr Thr

1625 1630 1635

Asp Pro Ser Phe Leu Gly Arg Tyr Met Ser Ala Leu Asn His Thr

1640 1645 1650

Lys Lys Trp Lys Tyr Pro Gln Val Asn Gly Leu Thr Ser Ile Lys

1655 1660 1665

Trp Ala Asp Asn Asn Cys Tyr Leu Ala Thr Ala Leu Leu Thr Leu

1670 1675 1680

Gln Gln Ile Glu Leu Lys Phe Asn Pro Pro Ala Leu Gln Asp Ala

1685 1690 1695

Tyr Tyr Arg Ala Arg Ala Gly Glu Ala Ala Asn Phe Cys Ala Leu

1700 1705 1710

Ile Leu Ala Tyr Cys Asn Lys Thr Val Gly Glu Leu Gly Asp Val

1715 1720 1725

Arg Glu Thr Met Ser Tyr Leu Phe Gln His Ala Asn Leu Asp Ser

1730 1735 1740

Cys Lys Arg Val Leu Asn Val Val Cys Lys Thr Cys Gly Gln Gln

1745 1750 1755

Gln Thr Thr Leu Lys Gly Val Glu Ala Val Met Tyr Met Gly Thr

1760 1765 1770

Leu Ser Tyr Glu Gln Phe Lys Lys Gly Val Gln Ile Pro Cys Thr

1775 1780 1785

Cys Gly Lys Gln Ala Thr Lys Tyr Leu Val Gln Gln Glu Ser Pro

1790 1795 1800

Phe Val Met Met Ser Ala Pro Pro Ala Gln Tyr Glu Leu Lys His

1805 1810 1815

Gly Thr Phe Thr Cys Ala Ser Glu Tyr Thr Gly Asn Tyr Gln Cys

1820 1825 1830

Gly His Tyr Lys His Ile Thr Ser Lys Glu Thr Leu Tyr Cys Ile

1835 1840 1845

Asp Gly Ala Leu Leu Thr Lys Ser Ser Glu Tyr Lys Gly Pro Ile

1850 1855 1860

Thr Asp Val Phe Tyr Lys Glu Asn Ser Tyr Thr Thr Thr Ile Lys

1865 1870 1875

Pro Val Thr Tyr Lys Leu Asp Gly Val Val Cys Thr Glu Ile Asp

1880 1885 1890

Pro Lys Leu Asp Asn Tyr Tyr Lys Lys Asp Asn Ser Tyr Phe Thr

1895 1900 1905

Glu Gln Pro Ile Asp Leu Val Pro Asn Gln Pro Tyr Pro Asn Ala

1910 1915 1920

Ser Phe Asp Asn Phe Lys Phe Val Cys Asp Asn Ile Lys Phe Ala

1925 1930 1935

Asp Asp Leu Asn Gln Leu Thr Gly Tyr Lys Lys Pro Ala Ser Arg

1940 1945 1950

Glu Leu Lys Val Thr Phe Phe Pro Asp Leu Asn Gly Asp Val Val

1955 1960 1965

Ala Ile Asp Tyr Lys His Tyr Thr Pro Ser Phe Lys Lys Gly Ala

1970 1975 1980

Lys Leu Leu His Lys Pro Ile Val Trp His Val Asn Asn Ala Thr

1985 1990 1995

Asn Lys Ala Thr Tyr Lys Pro Asn Thr Trp Cys Ile Arg Cys Leu

2000 2005 2010

Trp Ser Thr Lys Pro Val Glu Thr Ser Asn Ser Phe Asp Val Leu

2015 2020 2025

Lys Ser Glu Asp Ala Gln Gly Met Asp Asn Leu Ala Cys Glu Asp

2030 2035 2040

Leu Lys Pro Val Ser Glu Glu Val Val Glu Asn Pro Thr Ile Gln

2045 2050 2055

Lys Asp Val Leu Glu Cys Asn Val Lys Thr Thr Glu Val Val Gly

2060 2065 2070

Asp Ile Ile Leu Lys Pro Ala Asn Asn Ser Leu Lys Ile Thr Glu

2075 2080 2085

Glu Val Gly His Thr Asp Leu Met Ala Ala Tyr Val Asp Asn Ser

2090 2095 2100

Ser Leu Thr Ile Lys Lys Pro Asn Glu Leu Ser Arg Val Leu Gly

2105 2110 2115

Leu Lys Thr Leu Ala Thr His Gly Leu Ala Ala Val Asn Ser Val

2120 2125 2130

Pro Trp Asp Thr Ile Ala Asn Tyr Ala Lys Pro Phe Leu Asn Lys

2135 2140 2145

Val Val Ser Thr Thr Thr Asn Ile Val Thr Arg Cys Leu Asn Arg

2150 2155 2160

Val Cys Thr Asn Tyr Met Pro Tyr Phe Phe Thr Leu Leu Leu Gln

2165 2170 2175

Leu Cys Thr Phe Thr Arg Ser Thr Asn Ser Arg Ile Lys Ala Ser

2180 2185 2190

Met Pro Thr Thr Ile Ala Lys Asn Thr Val Lys Ser Val Gly Lys

2195 2200 2205

Phe Cys Leu Glu Ala Ser Phe Asn Tyr Leu Lys Ser Pro Asn Phe

2210 2215 2220

Ser Lys Leu Ile Asn Ile Ile Ile Trp Phe Leu Leu Leu Ser Val

2225 2230 2235

Cys Leu Gly Ser Leu Ile Tyr Ser Thr Ala Ala Leu Gly Val Leu

2240 2245 2250

Met Ser Asn Leu Gly Met Pro Ser Tyr Cys Thr Gly Tyr Arg Glu

2255 2260 2265

Gly Tyr Leu Asn Ser Thr Asn Val Thr Ile Ala Thr Tyr Cys Thr

2270 2275 2280

Gly Ser Ile Pro Cys Ser Val Cys Leu Ser Gly Leu Asp Ser Leu

2285 2290 2295

Asp Thr Tyr Pro Ser Leu Glu Thr Ile Gln Ile Thr Ile Ser Ser

2300 2305 2310

Phe Lys Trp Asp Leu Thr Ala Phe Gly Leu Val Ala Glu Trp Phe

2315 2320 2325

Leu Ala Tyr Ile Leu Phe Thr Arg Phe Phe Tyr Val Leu Gly Leu

2330 2335 2340

Ala Ala Ile Met Gln Leu Phe Phe Ser Tyr Phe Ala Val His Phe

2345 2350 2355

Ile Ser Asn Ser Trp Leu Met Trp Leu Ile Ile Asn Leu Val Gln

2360 2365 2370

Met Ala Pro Ile Ser Ala Met Val Arg Met Tyr Ile Phe Phe Ala

2375 2380 2385

Ser Phe Tyr Tyr Val Trp Lys Ser Tyr Val His Val Val Asp Gly

2390 2395 2400

Cys Asn Ser Ser Thr Cys Met Met Cys Tyr Lys Arg Asn Arg Ala

2405 2410 2415

Thr Arg Val Glu Cys Thr Thr Ile Val Asn Gly Val Arg Arg Ser

2420 2425 2430

Phe Tyr Val Tyr Ala Asn Gly Gly Lys Gly Phe Cys Lys Leu His

2435 2440 2445

Asn Trp Asn Cys Val Asn Cys Asp Thr Phe Cys Ala Gly Ser Thr

2450 2455 2460

Phe Ile Ser Asp Glu Val Ala Arg Asp Leu Ser Leu Gln Phe Lys

2465 2470 2475

Arg Pro Ile Asn Pro Thr Asp Gln Ser Ser Tyr Ile Val Asp Ser

2480 2485 2490

Val Thr Val Lys Asn Gly Ser Ile His Leu Tyr Phe Asp Lys Ala

2495 2500 2505

Gly Gln Lys Thr Tyr Glu Arg His Ser Leu Ser His Phe Val Asn

2510 2515 2520

Leu Asp Asn Leu Arg Ala Asn Asn Thr Lys Gly Ser Leu Pro Ile

2525 2530 2535

Asn Val Ile Val Phe Asp Gly Lys Ser Lys Cys Glu Glu Ser Ser

2540 2545 2550

Ala Lys Ser Ala Ser Val Tyr Tyr Ser Gln Leu Met Cys Gln Pro

2555 2560 2565

Ile Leu Leu Leu Asp Gln Ala Leu Val Ser Asp Val Gly Asp Ser

2570 2575 2580

Ala Glu Val Ala Val Lys Met Phe Asp Ala Tyr Val Asn Thr Phe

2585 2590 2595

Ser Ser Thr Phe Asn Val Pro Met Glu Lys Leu Lys Thr Leu Val

2600 2605 2610

Ala Thr Ala Glu Ala Glu Leu Ala Lys Asn Val Ser Leu Asp Asn

2615 2620 2625

Val Leu Ser Thr Phe Ile Ser Ala Ala Arg Gln Gly Phe Val Asp

2630 2635 2640

Ser Asp Val Glu Thr Lys Asp Val Val Glu Cys Leu Lys Leu Ser

2645 2650 2655

His Gln Ser Asp Ile Glu Val Thr Gly Asp Ser Cys Asn Asn Tyr

2660 2665 2670

Met Leu Thr Tyr Asn Lys Val Glu Asn Met Thr Pro Arg Asp Leu

2675 2680 2685

Gly Ala Cys Ile Asp Cys Ser Ala Arg His Ile Asn Ala Gln Val

2690 2695 2700

Ala Lys Ser His Asn Ile Ala Leu Ile Trp Asn Val Lys Asp Phe

2705 2710 2715

Met Ser Leu Ser Glu Gln Leu Arg Lys Gln Ile Arg Ser Ala Ala

2720 2725 2730

Lys Lys Asn Asn Leu Pro Phe Lys Leu Thr Cys Ala Thr Thr Arg

2735 2740 2745

Gln Val Val Asn Val Val Thr Thr Lys Ile Ala Leu Lys Gly Gly

2750 2755 2760

Lys Ile Val Asn Asn Trp Leu Lys Gln Leu Ile Lys Val Thr Leu

2765 2770 2775

Val Phe Leu Phe Val Ala Ala Ile Phe Tyr Leu Ile Thr Pro Val

2780 2785 2790

His Val Met Ser Lys His Thr Asp Phe Ser Ser Glu Ile Ile Gly

2795 2800 2805

Tyr Lys Ala Ile Asp Gly Gly Val Thr Arg Asp Ile Ala Ser Thr

2810 2815 2820

Asp Thr Cys Phe Ala Asn Lys His Ala Asp Phe Asp Thr Trp Phe

2825 2830 2835

Ser Gln Arg Gly Gly Ser Tyr Thr Asn Asp Lys Ala Cys Pro Leu

2840 2845 2850

Ile Ala Ala Val Ile Thr Arg Glu Val Gly Phe Val Val Pro Gly

2855 2860 2865

Leu Pro Gly Thr Ile Leu Arg Thr Thr Asn Gly Asp Phe Leu His

2870 2875 2880

Phe Leu Pro Arg Val Phe Ser Ala Val Gly Asn Ile Cys Tyr Thr

2885 2890 2895

Pro Ser Lys Leu Ile Glu Tyr Thr Asp Phe Ala Thr Ser Ala Cys

2900 2905 2910

Val Leu Ala Ala Glu Cys Thr Ile Phe Lys Asp Ala Ser Gly Lys

2915 2920 2925

Pro Val Pro Tyr Cys Tyr Asp Thr Asn Val Leu Glu Gly Ser Val

2930 2935 2940

Ala Tyr Glu Ser Leu Arg Pro Asp Thr Arg Tyr Val Leu Met Asp

2945 2950 2955

Gly Ser Ile Ile Gln Phe Pro Asn Thr Tyr Leu Glu Gly Ser Val

2960 2965 2970

Arg Val Val Thr Thr Phe Asp Ser Glu Tyr Cys Arg His Gly Thr

2975 2980 2985

Cys Glu Arg Ser Glu Ala Gly Val Cys Val Ser Thr Ser Gly Arg

2990 2995 3000

Trp Val Leu Asn Asn Asp Tyr Tyr Arg Ser Leu Pro Gly Val Phe

3005 3010 3015

Cys Gly Val Asp Ala Val Asn Leu Leu Thr Asn Met Phe Thr Pro

3020 3025 3030

Leu Ile Gln Pro Ile Gly Ala Leu Asp Ile Ser Ala Ser Ile Val

3035 3040 3045

Ala Gly Gly Ile Val Ala Ile Val Val Thr Cys Leu Ala Tyr Tyr

3050 3055 3060

Phe Met Arg Phe Arg Arg Ala Phe Gly Glu Tyr Ser His Val Val

3065 3070 3075

Ala Phe Asn Thr Leu Leu Phe Leu Met Ser Phe Thr Val Leu Cys

3080 3085 3090

Leu Thr Pro Val Tyr Ser Phe Leu Pro Gly Val Tyr Ser Val Ile

3095 3100 3105

Tyr Leu Tyr Leu Thr Phe Tyr Leu Thr Asn Asp Val Ser Phe Leu

3110 3115 3120

Ala His Ile Gln Trp Met Val Met Phe Thr Pro Leu Val Pro Phe

3125 3130 3135

Trp Ile Thr Ile Ala Tyr Ile Ile Cys Ile Ser Thr Lys His Phe

3140 3145 3150

Tyr Trp Phe Phe Ser Asn Tyr Leu Lys Arg Arg Val Val Phe Asn

3155 3160 3165

Gly Val Ser Phe Ser Thr Phe Glu Glu Ala Ala Leu Cys Thr Phe

3170 3175 3180

Leu Leu Asn Lys Glu Met Tyr Leu Lys Leu Arg Ser Asp Val Leu

3185 3190 3195

Leu Pro Leu Thr Gln Tyr Asn Arg Tyr Leu Ala Leu Tyr Asn Lys

3200 3205 3210

Tyr Lys Tyr Phe Ser Gly Ala Met Asp Thr Thr Ser Tyr Arg Glu

3215 3220 3225

Ala Ala Cys Cys His Leu Ala Lys Ala Leu Asn Asp Phe Ser Asn

3230 3235 3240

Ser Gly Ser Asp Val Leu Tyr Gln Pro Pro Gln Thr Ser Ile Thr

3245 3250 3255

Ser Ala Val Leu Gln Ser Gly Phe Arg Lys Met Ala Phe Pro Ser

3260 3265 3270

Gly Lys Val Glu Gly Cys Met Val Gln Val Thr Cys Gly Thr Thr

3275 3280 3285

Thr Leu Asn Gly Leu Trp Leu Asp Asp Val Val Tyr Cys Pro Arg

3290 3295 3300

His Val Ile Cys Thr Ser Glu Asp Met Leu Asn Pro Asn Tyr Glu

3305 3310 3315

Asp Leu Leu Ile Arg Lys Ser Asn His Asn Phe Leu Val Gln Ala

3320 3325 3330

Gly Asn Val Gln Leu Arg Val Ile Gly His Ser Met Gln Asn Cys

3335 3340 3345

Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro Lys Thr Pro Lys

3350 3355 3360

Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Phe Ser Val Leu

3365 3370 3375

Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys Ala Met

3380 3385 3390

Arg Pro Asn Phe Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser Cys

3395 3400 3405

Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys

3410 3415 3420

Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr

3425 3430 3435

Asp Leu Glu Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr

3440 3445 3450

Ala Gln Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu

3455 3460 3465

Ala Trp Leu Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu

3470 3475 3480

Asn Arg Phe Thr Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met

3485 3490 3495

Lys Tyr Asn Tyr Glu Pro Leu Thr Gln Asp His Val Asp Ile Leu

3500 3505 3510

Gly Pro Leu Ser Ala Gln Thr Gly Ile Ala Val Leu Asp Met Cys

3515 3520 3525

Ala Ser Leu Lys Glu Leu Leu Gln Asn Gly Met Asn Gly Arg Thr

3530 3535 3540

Ile Leu Gly Ser Ala Leu Leu Glu Asp Glu Phe Thr Pro Phe Asp

3545 3550 3555

Val Val Arg Gln Cys Ser Gly Val Thr Phe Gln Ser Ala Val Lys

3560 3565 3570

Arg Thr Ile Lys Gly Thr His His Trp Leu Leu Leu Thr Ile Leu

3575 3580 3585

Thr Ser Leu Leu Val Leu Val Gln Ser Thr Gln Trp Ser Leu Phe

3590 3595 3600

Phe Phe Xaa Tyr Glu Asn Ala Phe Leu Pro Phe Ala Met Gly Ile

3605 3610 3615

Ile Ala Met Ser Ala Phe Ala Met Met Phe Val Lys His Lys His

3620 3625 3630

Ala Phe Leu Cys Leu Phe Leu Leu Pro Ser Leu Ala Thr Val Ala

3635 3640 3645

Tyr Phe Asn Met Val Tyr Met Pro Ala Ser Trp Val Met Arg Ile

3650 3655 3660

Met Thr Trp Leu Asp Met Val Asp Thr Ser Leu Ser Gly Phe Lys

3665 3670 3675

Leu Lys Asp Cys Val Met Tyr Ala Ser Ala Val Val Leu Leu Ile

3680 3685 3690

Leu Met Thr Ala Arg Thr Val Tyr Asp Asp Gly Ala Arg Arg Val

3695 3700 3705

Trp Thr Leu Met Asn Val Leu Thr Leu Val Tyr Lys Val Tyr Tyr

3710 3715 3720

Gly Asn Ala Leu Asp Gln Ala Ile Ser Met Trp Ala Leu Ile Ile

3725 3730 3735

Ser Val Thr Ser Asn Tyr Ser Gly Val Val Thr Thr Val Met Phe

3740 3745 3750

Leu Ala Arg Gly Ile Val Phe Met Cys Val Glu Tyr Cys Pro Ile

3755 3760 3765

Phe Phe Ile Thr Gly Asn Thr Leu Gln Cys Ile Met Leu Val Tyr

3770 3775 3780

Cys Phe Leu Gly Tyr Phe Cys Thr Cys Tyr Phe Gly Leu Phe Cys

3785 3790 3795

Leu Leu Asn Arg Tyr Phe Arg Leu Thr Leu Gly Val Tyr Asp Tyr

3800 3805 3810

Leu Val Ser Thr Gln Glu Phe Arg Tyr Met Asn Ser Gln Gly Leu

3815 3820 3825

Leu Pro Pro Lys Asn Ser Ile Asp Ala Phe Lys Leu Asn Ile Lys

3830 3835 3840

Leu Leu Gly Val Gly Gly Lys Pro Cys Ile Lys Val Ala Thr Val

3845 3850 3855

Gln Ser Lys Met Ser Asp Val Lys Cys Thr Ser Val Val Leu Leu

3860 3865 3870

Ser Val Leu Gln Gln Leu Arg Val Glu Ser Ser Ser Lys Leu Trp

3875 3880 3885

Ala Gln Cys Val Gln Leu His Asn Asp Ile Leu Leu Ala Lys Asp

3890 3895 3900

Thr Thr Glu Ala Phe Glu Lys Met Val Ser Leu Leu Ser Val Leu

3905 3910 3915

Leu Ser Met Gln Gly Ala Val Asp Ile Asn Lys Leu Cys Glu Glu

3920 3925 3930

Met Leu Asp Asn Arg Ala Thr Leu Gln Ala Ile Ala Ser Glu Phe

3935 3940 3945

Ser Ser Leu Pro Ser Tyr Ala Ala Phe Ala Thr Ala Gln Glu Ala

3950 3955 3960

Tyr Glu Gln Ala Val Ala Asn Gly Asp Ser Glu Val Val Leu Lys

3965 3970 3975

Lys Leu Lys Lys Ser Leu Asn Val Ala Lys Ser Glu Phe Asp Arg

3980 3985 3990

Asp Ala Ala Met Gln Arg Lys Leu Glu Lys Met Ala Asp Gln Ala

3995 4000 4005

Met Thr Gln Met Tyr Lys Gln Ala Arg Ser Glu Asp Lys Arg Ala

4010 4015 4020

Lys Val Thr Ser Ala Met Gln Thr Met Leu Phe Thr Met Leu Arg

4025 4030 4035

Lys Leu Asp Asn Asp Ala Leu Asn Asn Ile Ile Asn Asn Ala Arg

4040 4045 4050

Asp Gly Cys Val Pro Leu Asn Ile Ile Pro Leu Thr Thr Ala Ala

4055 4060 4065

Lys Leu Met Val Val Ile Pro Asp Tyr Asn Thr Tyr Lys Asn Thr

4070 4075 4080

Cys Asp Gly Thr Thr Phe Thr Tyr Ala Ser Ala Leu Trp Glu Ile

4085 4090 4095

Gln Gln Val Val Asp Ala Asp Ser Lys Ile Val Gln Leu Ser Glu

4100 4105 4110

Ile Ser Met Asp Asn Ser Pro Asn Leu Ala Trp Pro Leu Ile Val

4115 4120 4125

Thr Ala Leu Arg Ala Asn Ser Ala Val Lys Leu Gln Asn Asn Glu

4130 4135 4140

Leu Ser Pro Val Ala Leu Arg Gln Met Ser Cys Ala Ala Gly Thr

4145 4150 4155

Thr Gln Thr Ala Cys Thr Asp Asp Asn Ala Leu Ala Tyr Tyr Asn

4160 4165 4170

Thr Thr Lys Gly Gly Arg Phe Val Leu Ala Leu Leu Ser Asp Leu

4175 4180 4185

Gln Asp Leu Lys Trp Ala Arg Phe Pro Lys Ser Asp Gly Thr Gly

4190 4195 4200

Thr Ile Tyr Thr Glu Leu Glu Pro Pro Cys Arg Phe Val Thr Asp

4205 4210 4215

Thr Pro Lys Gly Pro Lys Val Lys Tyr Leu Tyr Phe Ile Lys Gly

4220 4225 4230

Leu Asn Asn Leu Asn Arg Gly Met Val Leu Gly Ser Leu Ala Ala

4235 4240 4245

Thr Val Arg Leu Gln Ala Gly Asn Ala Thr Glu Val Pro Ala Asn

4250 4255 4260

Ser Thr Val Leu Ser Phe Cys Ala Phe Ala Val Asp Ala Ala Lys

4265 4270 4275

Ala Tyr Lys Asp Tyr Leu Ala Ser Gly Gly Gln Pro Ile Thr Asn

4280 4285 4290

Cys Val Lys Met Leu Cys Thr His Thr Gly Thr Gly Gln Ala Ile

4295 4300 4305

Thr Val Thr Pro Glu Ala Asn Met Asp Gln Glu Ser Phe Gly Gly

4310 4315 4320

Ala Ser Cys Cys Leu Tyr Cys Arg Cys His Ile Asp His Pro Asn

4325 4330 4335

Pro Lys Gly Phe Cys Asp Leu Lys Gly Lys Tyr Val Gln Ile Pro

4340 4345 4350

Thr Thr Cys Ala Asn Asp Pro Val Gly Phe Thr Leu Lys Asn Thr

4355 4360 4365

Val Cys Thr Val Cys Gly Met Trp Lys Gly Tyr Gly Cys Ser Cys

4370 4375 4380

Asp Gln Leu Arg Glu Pro Met Leu Gln Ser Ala Asp Ala Gln Ser

4385 4390 4395

Phe Leu Asn Arg Val Cys Gly Val Ser Ala Ala Arg Leu Thr Pro

4400 4405 4410

Cys Gly Thr Gly Thr Ser Thr Asp Val Val Tyr Arg Ala Phe Asp

4415 4420 4425

Ile Tyr Asn Asp Lys Val Ala Gly Phe Ala Lys Phe Leu Lys Thr

4430 4435 4440

Asn Cys Cys Arg Phe Gln Glu Lys Asp Glu Asp Asp Asn Leu Ile

4445 4450 4455

Asp Ser Tyr Phe Val Val Lys Arg His Thr Phe Ser Asn Tyr Gln

4460 4465 4470

His Glu Glu Thr Ile Tyr Asn Leu Leu Lys Asp Cys Pro Ala Val

4475 4480 4485

Ala Lys His Asp Phe Phe Lys Phe Arg Ile Asp Gly Asp Met Val

4490 4495 4500

Pro His Ile Ser Arg Gln Arg Leu Thr Lys Tyr Thr Met Ala Asp

4505 4510 4515

Leu Val Tyr Ala Leu Arg His Phe Asp Glu Gly Asn Cys Asp Thr

4520 4525 4530

Leu Lys Glu Ile Leu Val Thr Tyr Asn Cys Cys Asp Asp Asp Tyr

4535 4540 4545

Phe Asn Lys Lys Asp Trp Tyr Asp Phe Val Glu Asn Pro Asp Ile

4550 4555 4560

Leu Arg Val Tyr Ala Asn Leu Gly Glu Arg Val Arg Gln Ala Leu

4565 4570 4575

Leu Lys Thr Val Gln Phe Cys Asp Ala Met Arg Asn Ala Gly Ile

4580 4585 4590

Val Gly Val Leu Thr Leu Asp Asn Gln Asp Leu Asn Gly Asn Trp

4595 4600 4605

Tyr Asp Phe Gly Asp Phe Ile Gln Thr Thr Pro Gly Ser Gly Val

4610 4615 4620

Pro Val Val Asp Ser Tyr Tyr Ser Leu Leu Met Pro Ile Leu Thr

4625 4630 4635

Leu Thr Arg Ala Leu Thr Ala Glu Ser His Val Asp Thr Asp Leu

4640 4645 4650

Thr Lys Pro Tyr Ile Lys Trp Asp Leu Leu Lys Tyr Asp Phe Thr

4655 4660 4665

Glu Glu Arg Leu Lys Leu Phe Asp Arg Tyr Phe Lys Tyr Trp Asp

4670 4675 4680

Gln Thr Tyr His Pro Asn Cys Val Asn Cys Leu Asp Asp Arg Cys

4685 4690 4695

Ile Leu His Cys Ala Asn Phe Asn Val Leu Phe Ser Thr Val Phe

4700 4705 4710

Pro Pro Thr Ser Phe Gly Pro Leu Val Arg Lys Ile Phe Val Asp

4715 4720 4725

Gly Val Pro Phe Val Val Ser Thr Gly Tyr His Phe Arg Glu Leu

4730 4735 4740

Gly Val Val His Asn Gln Asp Val Asn Leu His Ser Ser Arg Leu

4745 4750 4755

Ser Phe Lys Glu Leu Leu Val Tyr Ala Ala Asp Pro Ala Met His

4760 4765 4770

Ala Ala Ser Gly Asn Leu Leu Leu Asp Lys Arg Thr Thr Cys Phe

4775 4780 4785

Ser Val Ala Ala Leu Thr Asn Asn Val Ala Phe Gln Thr Val Lys

4790 4795 4800

Pro Gly Asn Phe Asn Lys Asp Phe Tyr Asp Phe Ala Val Ser Lys

4805 4810 4815

Gly Phe Phe Lys Glu Gly Ser Ser Val Glu Leu Lys His Phe Phe

4820 4825 4830

Phe Ala Gln Asp Gly Asn Ala Ala Ile Ser Asp Tyr Asp Tyr Tyr

4835 4840 4845

Arg Tyr Asn Leu Pro Thr Met Cys Asp Ile Arg Gln Leu Leu Phe

4850 4855 4860

Val Val Glu Val Val Asp Lys Tyr Phe Asp Cys Tyr Asp Gly Gly

4865 4870 4875

Cys Ile Asn Ala Asn Gln Val Ile Val Asn Asn Leu Asp Lys Ser

4880 4885 4890

Ala Gly Phe Pro Phe Asn Lys Trp Gly Lys Ala Arg Leu Tyr Tyr

4895 4900 4905

Asp Ser Met Ser Tyr Glu Asp Gln Asp Ala Leu Phe Ala Tyr Thr

4910 4915 4920

Lys Arg Asn Val Ile Pro Thr Ile Thr Gln Met Asn Leu Lys Tyr

4925 4930 4935

Ala Ile Ser Ala Lys Asn Arg Ala Arg Thr Val Ala Gly Val Ser

4940 4945 4950

Ile Cys Ser Thr Met Thr Asn Arg Gln Phe His Gln Lys Leu Leu

4955 4960 4965

Lys Ser Ile Ala Ala Thr Arg Gly Ala Thr Val Val Ile Gly Thr

4970 4975 4980

Ser Lys Phe Tyr Gly Gly Trp His Asn Met Leu Lys Thr Val Tyr

4985 4990 4995

Ser Asp Val Glu Asn Pro His Leu Met Gly Trp Asp Tyr Pro Lys

5000 5005 5010

Cys Asp Arg Ala Met Pro Asn Met Leu Arg Ile Met Ala Ser Leu

5015 5020 5025

Val Leu Ala Arg Lys His Thr Thr Cys Cys Ser Leu Ser His Arg

5030 5035 5040

Phe Tyr Arg Leu Ala Asn Glu Cys Ala Gln Val Leu Ser Glu Met

5045 5050 5055

Val Met Cys Gly Gly Ser Leu Tyr Val Lys Pro Gly Gly Thr Ser

5060 5065 5070

Ser Gly Asp Ala Thr Thr Ala Tyr Ala Asn Ser Val Phe Asn Ile

5075 5080 5085

Cys Gln Ala Val Thr Ala Asn Val Asn Ala Leu Leu Ser Thr Asp

5090 5095 5100

Gly Asn Lys Ile Ala Asp Lys Tyr Val Arg Asn Leu Gln His Arg

5105 5110 5115

Leu Tyr Glu Cys Leu Tyr Arg Asn Arg Asp Val Asp Thr Asp Phe

5120 5125 5130

Val Asn Glu Phe Tyr Ala Tyr Leu Arg Lys His Phe Ser Met Met

5135 5140 5145

Ile Leu Ser Asp Asp Ala Val Val Cys Phe Asn Ser Thr Tyr Ala

5150 5155 5160

Ser Gln Gly Leu Val Ala Ser Ile Lys Asn Phe Lys Ser Val Leu

5165 5170 5175

Tyr Tyr Gln Asn Asn Val Phe Met Ser Glu Ala Lys Cys Trp Thr

5180 5185 5190

Glu Thr Asp Leu Thr Lys Gly Pro His Glu Phe Cys Ser Gln His

5195 5200 5205

Thr Met Leu Val Lys Gln Gly Asp Asp Tyr Val Tyr Leu Pro Tyr

5210 5215 5220

Pro Asp Pro Ser Arg Ile Leu Gly Ala Gly Cys Phe Val Asp Asp

5225 5230 5235

Ile Val Lys Thr Asp Gly Thr Leu Met Ile Glu Arg Phe Val Ser

5240 5245 5250

Leu Ala Ile Asp Ala Tyr Pro Leu Thr Lys His Pro Asn Gln Glu

5255 5260 5265

Tyr Ala Asp Val Phe His Leu Tyr Leu Gln Tyr Ile Arg Lys Leu

5270 5275 5280

His Asp Glu Leu Thr Gly His Met Leu Asp Met Tyr Ser Val Met

5285 5290 5295

Leu Thr Asn Asp Asn Thr Ser Arg Tyr Trp Glu Pro Glu Phe Tyr

5300 5305 5310

Glu Ala Met Tyr Thr Pro His Thr Val Leu Gln Ala Val Gly Ala

5315 5320 5325

Cys Val Leu Cys Asn Ser Gln Thr Ser Leu Arg Cys Gly Ala Cys

5330 5335 5340

Ile Arg Arg Pro Phe Leu Cys Cys Lys Cys Cys Tyr Asp His Val

5345 5350 5355

Ile Ser Thr Ser His Lys Leu Val Leu Ser Val Asn Pro Tyr Val

5360 5365 5370

Cys Asn Ala Pro Gly Cys Asp Val Thr Asp Val Thr Gln Leu Tyr

5375 5380 5385

Leu Gly Gly Met Ser Tyr Tyr Cys Lys Ser His Lys Pro Pro Ile

5390 5395 5400

Ser Phe Pro Leu Cys Ala Asn Gly Gln Val Phe Gly Leu Tyr Lys

5405 5410 5415

Asn Thr Cys Val Gly Ser Asp Asn Val Thr Asp Phe Asn Ala Ile

5420 5425 5430

Ala Thr Cys Asp Trp Thr Asn Ala Gly Asp Tyr Ile Leu Ala Asn

5435 5440 5445

Thr Cys Thr Glu Arg Leu Lys Leu Phe Ala Ala Glu Thr Leu Lys

5450 5455 5460

Ala Thr Glu Glu Thr Phe Lys Leu Ser Tyr Gly Ile Ala Thr Val

5465 5470 5475

Arg Glu Val Leu Ser Asp Arg Glu Leu His Leu Ser Trp Glu Val

5480 5485 5490

Gly Lys Pro Arg Pro Pro Leu Asn Arg Asn Tyr Val Phe Thr Gly

5495 5500 5505

Tyr Arg Val Thr Lys Asn Ser Lys Val Gln Ile Gly Glu Tyr Thr

5510 5515 5520

Phe Glu Lys Gly Asp Tyr Gly Asp Ala Val Val Tyr Arg Gly Thr

5525 5530 5535

Thr Thr Tyr Lys Leu Asn Val Gly Asp Tyr Phe Val Leu Thr Ser

5540 5545 5550

His Thr Val Met Pro Leu Ser Ala Pro Thr Leu Val Pro Gln Glu

5555 5560 5565

His Tyr Val Arg Ile Thr Gly Leu Tyr Pro Thr Leu Asn Ile Ser

5570 5575 5580

Asp Glu Phe Ser Ser Asn Val Ala Asn Tyr Gln Lys Val Gly Met

5585 5590 5595

Gln Lys Tyr Ser Thr Leu Gln Gly Pro Pro Gly Thr Gly Lys Ser

5600 5605 5610

His Phe Ala Ile Gly Leu Ala Leu Tyr Tyr Pro Ser Ala Arg Ile

5615 5620 5625

Val Tyr Thr Ala Cys Ser His Ala Ala Val Asp Ala Leu Cys Glu

5630 5635 5640

Lys Ala Leu Lys Tyr Leu Pro Ile Asp Lys Cys Ser Arg Ile Ile

5645 5650 5655

Pro Ala Arg Ala Arg Val Glu Cys Phe Asp Lys Phe Lys Val Asn

5660 5665 5670

Ser Thr Leu Glu Gln Tyr Val Phe Cys Thr Val Asn Ala Leu Pro

5675 5680 5685

Glu Thr Thr Ala Asp Ile Val Val Phe Asp Glu Ile Ser Met Ala

5690 5695 5700

Thr Asn Tyr Asp Leu Ser Val Val Asn Ala Arg Leu Arg Ala Lys

5705 5710 5715

His Tyr Val Tyr Ile Gly Asp Pro Ala Gln Leu Pro Ala Pro Arg

5720 5725 5730

Thr Leu Leu Thr Lys Gly Thr Leu Glu Pro Glu Tyr Phe Asn Ser

5735 5740 5745

Val Cys Arg Leu Met Lys Thr Ile Gly Pro Asp Met Phe Leu Gly

5750 5755 5760

Thr Cys Arg Arg Cys Pro Ala Glu Ile Val Asp Thr Val Ser Ala

5765 5770 5775

Leu Val Tyr Asp Asn Lys Leu Lys Ala His Lys Asp Lys Ser Ala

5780 5785 5790

Gln Cys Phe Lys Met Phe Tyr Lys Gly Val Ile Thr His Asp Val

5795 5800 5805

Ser Ser Ala Ile Asn Arg Pro Gln Ile Gly Val Val Arg Glu Phe

5810 5815 5820

Leu Thr Arg Asn Pro Ala Trp Arg Lys Ala Val Phe Ile Ser Pro

5825 5830 5835

Tyr Asn Ser Gln Asn Ala Val Ala Ser Lys Ile Leu Gly Leu Pro

5840 5845 5850

Thr Gln Thr Val Asp Ser Ser Gln Gly Ser Glu Tyr Asp Tyr Val

5855 5860 5865

Ile Phe Thr Gln Thr Thr Glu Thr Ala His Ser Cys Asn Val Asn

5870 5875 5880

Arg Phe Asn Val Ala Ile Thr Arg Ala Lys Val Gly Ile Leu Cys

5885 5890 5895

Ile Met Ser Asp Arg Asp Leu Tyr Asp Lys Leu Gln Phe Thr Ser

5900 5905 5910

Leu Glu Ile Pro Arg Arg Asn Val Ala Thr Leu Gln Ala Glu Asn

5915 5920 5925

Val Thr Gly Leu Phe Lys Asp Cys Ser Lys Val Ile Thr Gly Leu

5930 5935 5940

His Pro Thr Gln Ala Pro Thr His Leu Ser Val Asp Thr Lys Phe

5945 5950 5955

Lys Thr Glu Gly Leu Cys Val Asp Ile Pro Gly Ile Pro Lys Asp

5960 5965 5970

Met Thr Tyr Arg Arg Leu Ile Ser Met Met Gly Phe Lys Met Asn

5975 5980 5985

Tyr Gln Val Asn Gly Tyr Pro Asn Met Phe Ile Thr Arg Glu Glu

5990 5995 6000

Ala Ile Arg His Val Arg Ala Trp Ile Gly Phe Asp Val Glu Gly

6005 6010 6015

Cys His Ala Thr Arg Glu Ala Val Gly Thr Asn Leu Pro Leu Gln

6020 6025 6030

Leu Gly Phe Ser Thr Gly Val Asn Leu Val Ala Val Pro Thr Gly

6035 6040 6045

Tyr Val Asp Thr Pro Asn Asn Thr Asp Phe Ser Arg Val Ser Ala

6050 6055 6060

Lys Pro Pro Pro Gly Asp Gln Phe Lys His Leu Ile Pro Leu Met

6065 6070 6075

Tyr Lys Gly Leu Pro Trp Asn Val Val Arg Ile Lys Ile Val Gln

6080 6085 6090

Met Leu Ser Asp Thr Leu Lys Asn Leu Ser Asp Arg Val Val Phe

6095 6100 6105

Val Leu Trp Ala His Gly Phe Glu Leu Thr Ser Met Lys Tyr Phe

6110 6115 6120

Val Lys Ile Gly Pro Glu Arg Thr Cys Cys Leu Cys Asp Arg Arg

6125 6130 6135

Ala Thr Cys Phe Ser Thr Ala Ser Asp Thr Tyr Ala Cys Trp His

6140 6145 6150

His Ser Ile Gly Phe Asp Tyr Val Tyr Asn Pro Phe Met Ile Asp

6155 6160 6165

Val Gln Gln Trp Gly Phe Thr Gly Asn Leu Gln Ser Asn His Asp

6170 6175 6180

Leu Tyr Cys Gln Val His Gly Asn Ala His Val Ala Ser Cys Asp

6185 6190 6195

Ala Ile Met Thr Arg Cys Leu Ala Val His Glu Cys Phe Val Lys

6200 6205 6210

Arg Val Asp Trp Thr Ile Glu Tyr Pro Ile Ile Gly Asp Glu Leu

6215 6220 6225

Lys Ile Asn Ala Ala Cys Arg Lys Val Gln His Met Val Val Lys

6230 6235 6240

Ala Ala Leu Leu Ala Asp Lys Phe Pro Val Leu His Asp Ile Gly

6245 6250 6255

Asn Pro Lys Ala Ile Lys Cys Val Pro Gln Ala Asp Val Glu Trp

6260 6265 6270

Lys Phe Tyr Asp Ala Gln Pro Cys Ser Asp Lys Ala Tyr Lys Ile

6275 6280 6285

Glu Glu Leu Phe Tyr Ser Tyr Ala Thr His Ser Asp Lys Phe Thr

6290 6295 6300

Asp Gly Val Cys Leu Phe Trp Asn Cys Asn Val Asp Arg Tyr Pro

6305 6310 6315

Ala Asn Ser Ile Val Cys Arg Phe Asp Thr Arg Val Leu Ser Asn

6320 6325 6330

Leu Asn Leu Pro Gly Cys Asp Gly Gly Ser Leu Tyr Val Asn Lys

6335 6340 6345

His Ala Phe His Thr Pro Ala Phe Asp Lys Ser Ala Phe Val Asn

6350 6355 6360

Leu Lys Gln Leu Pro Phe Phe Tyr Tyr Ser Asp Ser Pro Cys Glu

6365 6370 6375

Ser His Gly Lys Gln Val Val Ser Asp Ile Asp Tyr Val Pro Leu

6380 6385 6390

Lys Ser Ala Thr Cys Ile Thr Arg Cys Asn Leu Gly Gly Ala Val

6395 6400 6405

Cys Arg His His Ala Asn Glu Tyr Arg Leu Tyr Leu Asp Ala Tyr

6410 6415 6420

Asn Met Met Ile Ser Ala Gly Phe Ser Leu Trp Val Tyr Lys Gln

6425 6430 6435

Phe Asp Thr Tyr Asn Leu Trp Asn Thr Phe Thr Arg Leu Gln Ser

6440 6445 6450

Leu Glu Asn Val Ala Phe Asn Val Val Asn Lys Gly His Phe Asp

6455 6460 6465

Gly Gln Gln Gly Glu Val Pro Val Ser Ile Ile Asn Asn Thr Val

6470 6475 6480

Tyr Thr Lys Val Asp Gly Val Asp Val Glu Leu Phe Glu Asn Lys

6485 6490 6495

Thr Thr Leu Pro Val Asn Val Ala Phe Glu Leu Trp Ala Lys Arg

6500 6505 6510

Asn Ile Lys Pro Val Pro Glu Val Lys Ile Leu Asn Asn Leu Gly

6515 6520 6525

Val Asp Ile Ala Ala Asn Thr Val Ile Trp Asp Tyr Lys Arg Asp

6530 6535 6540

Ala Pro Ala His Ile Ser Thr Ile Gly Val Cys Ser Met Thr Asp

6545 6550 6555

Ile Ala Lys Lys Pro Thr Glu Thr Ile Cys Ala Pro Leu Thr Val

6560 6565 6570

Phe Phe Asp Gly Arg Val Asp Gly Gln Val Asp Leu Phe Arg Asn

6575 6580 6585

Ala Arg Asn Gly Val Leu Ile Thr Glu Gly Ser Val Lys Gly Leu

6590 6595 6600

Gln Pro Ser Val Gly Pro Lys Gln Ala Ser Leu Asn Gly Val Thr

6605 6610 6615

Leu Ile Gly Glu Ala Val Lys Thr Gln Phe Asn Tyr Tyr Lys Lys

6620 6625 6630

Val Asp Gly Val Val Gln Gln Leu Pro Glu Thr Tyr Phe Thr Gln

6635 6640 6645

Ser Arg Asn Leu Gln Glu Phe Lys Pro Arg Ser Gln Met Glu Ile

6650 6655 6660

Asp Phe Leu Glu Leu Ala Met Asp Glu Phe Ile Glu Arg Tyr Lys

6665 6670 6675

Leu Glu Gly Tyr Ala Phe Glu His Ile Val Tyr Gly Asp Phe Ser

6680 6685 6690

His Ser Gln Leu Gly Gly Leu His Leu Leu Ile Gly Leu Ala Lys

6695 6700 6705

Arg Phe Lys Glu Ser Pro Phe Glu Leu Glu Asp Phe Ile Pro Met

6710 6715 6720

Asp Ser Thr Val Lys Asn Tyr Phe Ile Thr Asp Ala Gln Thr Gly

6725 6730 6735

Ser Ser Lys Cys Val Cys Ser Val Ile Asp Leu Leu Leu Asp Asp

6740 6745 6750

Phe Val Glu Ile Ile Lys Ser Gln Asp Leu Ser Val Val Ser Lys

6755 6760 6765

Val Val Lys Val Thr Ile Asp Tyr Thr Glu Ile Ser Phe Met Leu

6770 6775 6780

Trp Cys Lys Asp Gly His Val Glu Thr Phe Tyr Pro Lys Leu Gln

6785 6790 6795

Ser Ser Gln Ala Trp Gln Pro Gly Val Ala Met Pro Asn Leu Tyr

6800 6805 6810

Lys Met Gln Arg Met Leu Leu Glu Lys Cys Asp Leu Gln Asn Tyr

6815 6820 6825

Gly Asp Ser Ala Thr Leu Pro Lys Gly Ile Met Met Asn Val Ala

6830 6835 6840

Lys Tyr Thr Gln Leu Cys Gln Tyr Leu Asn Thr Leu Thr Leu Ala

6845 6850 6855

Val Pro Tyr Asn Met Arg Val Ile His Phe Gly Ala Gly Ser Asp

6860 6865 6870

Lys Gly Val Ala Pro Gly Thr Ala Val Leu Arg Gln Trp Leu Pro

6875 6880 6885

Thr Gly Thr Leu Leu Val Asp Ser Asp Leu Asn Asp Phe Val Ser

6890 6895 6900

Asp Ala Asp Ser Thr Leu Ile Gly Asp Cys Ala Thr Val His Thr

6905 6910 6915

Ala Asn Lys Trp Asp Leu Ile Ile Ser Asp Met Tyr Asp Pro Lys

6920 6925 6930

Thr Lys Asn Val Thr Lys Glu Asn Asp Ser Lys Glu Gly Phe Phe

6935 6940 6945

Thr Tyr Ile Cys Gly Phe Ile Gln Gln Lys Leu Ala Leu Gly Gly

6950 6955 6960

Ser Val Ala Ile Lys Ile Thr Glu His Ser Trp Asn Ala Asp Leu

6965 6970 6975

Tyr Lys Leu Met Gly His Phe Ala Trp Trp Thr Ala Phe Val Thr

6980 6985 6990

Asn Val Asn Ala Ser Ser Ser Glu Ala Phe Leu Ile Gly Cys Asn

6995 7000 7005

Tyr Leu Gly Lys Pro Arg Glu Gln Ile Asp Gly Tyr Val Met His

7010 7015 7020

Ala Asn Tyr Ile Phe Trp Arg Asn Thr Asn Pro Ile Gln Leu Ser

7025 7030 7035

Ser Tyr Ser Leu Phe Asp Met Ser Lys Phe Pro Leu Lys Leu Arg

7040 7045 7050

Gly Thr Ala Val Met Ser Leu Lys Glu

7055 7060

<210> 11

<211> 1273

<212> PRT

<213> SARS-CoV2

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Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val

1 5 10 15

Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe

20 25 30

Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu

35 40 45

His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp

50 55 60

Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp

65 70 75 80

Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu

85 90 95

Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser

100 105 110

Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile

115 120 125

Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr

130 135 140

Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr

145 150 155 160

Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu

165 170 175

Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe

180 185 190

Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr

195 200 205

Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu

210 215 220

Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr

225 230 235 240

Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser

245 250 255

Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro

260 265 270

Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala

275 280 285

Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys

290 295 300

Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val

305 310 315 320

Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys

325 330 335

Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala

340 345 350

Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu

355 360 365

Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro

370 375 380

Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe

385 390 395 400

Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly

405 410 415

Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys

420 425 430

Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn

435 440 445

Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe

450 455 460

Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys

465 470 475 480

Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly

485 490 495

Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val

500 505 510

Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys

515 520 525

Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn

530 535 540

Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu

545 550 555 560

Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val

565 570 575

Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe

580 585 590

Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val

595 600 605

Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile

610 615 620

His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser

625 630 635 640

Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val

645 650 655

Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala

660 665 670

Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala

675 680 685

Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser

690 695 700

Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile

705 710 715 720

Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val

725 730 735

Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu

740 745 750

Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr

755 760 765

Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln

770 775 780

Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe

785 790 795 800

Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser

805 810 815

Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly

820 825 830

Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp

835 840 845

Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu

850 855 860

Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly

865 870 875 880

Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile

885 890 895

Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr

900 905 910

Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn

915 920 925

Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala

930 935 940

Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn

945 950 955 960

Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val

965 970 975

Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln

980 985 990

Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val

995 1000 1005

Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn

1010 1015 1020

Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys

1025 1030 1035

Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro

1040 1045 1050

Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val

1055 1060 1065

Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His

1070 1075 1080

Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn

1085 1090 1095

Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln

1100 1105 1110

Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val

1115 1120 1125

Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro

1130 1135 1140

Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn

1145 1150 1155

His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn

1160 1165 1170

Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu

1175 1180 1185

Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu

1190 1195 1200

Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu

1205 1210 1215

Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met

1220 1225 1230

Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys

1235 1240 1245

Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro

1250 1255 1260

Val Leu Lys Gly Val Lys Leu His Tyr Thr

1265 1270

<210> 12

<211> 29874

<212> DNA

<213> SARS-CoV2

<400> 12

attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct 60

gttctctaaa cgaactttaa aatctgtgtg gctgtcactc ggctgcatgc ttagtgcact 120

cacgcagtat aattaataac taattactgt cgttgacagg acacgagtaa ctcgtctatc 180

ttctgcaggc tgcttacggt ttcgtccgtg ttgcagccga tcatcagcac atctaggttt 240

cgtccgggtg tgaccgaaag gtaagatgga gagccttgtc cctggtttca acgagaaaac 300

acacgtccaa ctcagtttgc ctgttttaca ggttcgcgac gtgctcgtac gtggctttgg 360

agactccgtg gaggaggtct tatcagaggc acgtcaacat cttaaagatg gcacttgtgg 420

cttagtagaa gttgaaaaag gcgttttgcc tcaacttgaa cagccctatg tgttcatcaa 480

acgttcggat gctcgaactg cacctcatgg tcatgttatg gttgagctgg tagcagaact 540

cgaaggcatt cagtacggtc gtagtggtga gacacttggt gtccttgtcc ctcatgtggg 600

cgaaatacca gtggcttacc gcaaggttct tcttcgtaag aacggtaata aaggagctgg 660

tggccatagt tacggcgccg atctaaagtc atttgactta ggcgacgagc ttggcactga 720

tccttatgaa gattttcaag aaaactggaa cactaaacat agcagtggtg ttacccgtga 780

actcatgcgt gagcttaacg gaggggcata cactcgctat gtcgataaca acttctgtgg 840

ccctgatggc taccctcttg agtgcattaa agaccttcta gcacgtgctg gtaaagcttc 900

atgcactttg tccgaacaac tggactttat tgacactaag aggggtgtat actgctgccg 960

tgaacatgag catgaaattg cttggtacac ggaacgttct gaaaagagct atgaattgca 1020

gacacctttt gaaattaaat tggcaaagaa atttgacacc ttcaatgggg aatgtccaaa 1080

ttttgtattt cccttaaatt ccataatcaa gactattcaa ccaagggttg aaaagaaaaa 1140

gcttgatggc tttatgggta gaattcgatc tgtctatcca gttgcgtcac caaatgaatg 1200

caaccaaatg tgcctttcaa ctctcatgaa gtgtgatcat tgtggtgaaa cttcatggca 1260

gacgggcgat tttgttaaag ccacttgcga attttgtggc actgagaatt tgactaaaga 1320

aggtgccact acttgtggtt acttacccca aaatgctgtt gttaaaattt attgtccagc 1380

atgtcacaat tcagaagtag gacctgagca tagtcttgcc gaataccata atgaatctgg 1440

cttgaaaacc attcttcgta agggtggtcg cactattgcc tttggaggct gtgtgttctc 1500

ttatgttggt tgccataaca agtgtgccta ttgggttcca cgtgctagcg ctaacatagg 1560

ttgtaaccat acaggtgttg ttggagaagg ttccgaaggt cttaatgaca accttcttga 1620

aatactccaa aaagagaaag tcaacatcaa tattgttggt gactttaaac ttaatgaaga 1680

gatcgccatt attttggcat ctttttctgc ttccacaagt gcttttgtgg aaactgtgaa 1740

aggtttggat tataaagcat tcaaacaaat tgttgaatcc tgtggtaatt ttaaagttac 1800

aaaaggaaaa gctaaaaaag gtgcctggaa tattggtgaa cagaaatcaa tactgagtcc 1860

tctttatgca tttgcatcag aggctgctcg tgttgtacga tcaattttct cccgcactct 1920

tgaaactgct caaaattctg tgcgtgtttt acagaaggcc gctataacaa tactagatgg 1980

aatttcacag tattcactga gactcattga tgctatgatg ttcacatctg atttggctac 2040

taacaatcta gttgtaatgg cctacattac aggtggtgtt gttcagttga cttcgcagtg 2100

gctaactaac atctttggca ctgtttatga aaaactcaaa cccgtccttg attggcttga 2160

agagaagttt aaggaaggtg tagagtttct tagagacggt tgggaaattg ttaaatttat 2220

ctcaacctgt gcttgtgaaa ttgtcggtgg acaaattgtc acctgtgcaa aggaaattaa 2280

ggagagtgtt cagacattct ttaagcttgt aaataaattt ttggctttgt gtgctgactc 2340

tatcattatt ggtggagcta aacttaaagc cttgaattta ggtgaaacat ttgtcacgca 2400

ctcaaaggga ttgtacagaa agtgtgttaa atccagagaa gaaactggcc tactcatgcc 2460

tctaaaagcc ccaaaagaaa ttatcttctt agagggagaa acacttccca cagaagtgtt 2520

aacagaggaa gttgtcttga aaactggtga tttacaacca ttagaacaac ctactagtga 2580

agctgttgaa gctccattgg ttggtacacc agtttgtatt aacgggctta tgttgctcga 2640

aatcaaagac acagaaaagt actgtgccct tgcacctaat atgatggtaa caaacaatac 2700

cttcacactc aaaggcggtg caccaacaaa ggttactttt ggtgatgaca ctgtgataga 2760

agtgcaaggt tacaagagtg tgaatatcac ttttgaactt gatgaaagga ttgataaagt 2820

acttaatgag aagtgctctg cctatacagt tgaactcggt acagaagtaa atgagttcgc 2880

ctgtgttgtg gcagatgctg tcataaaaac tttgcaacca gtatctgaat tacttacacc 2940

actgggcatt gatttagatg agtggagtat ggctacatac tacttatttg atgagtctgg 3000

tgagtttaaa ttggcttcac atatgtattg ttctttctac cctccagatg aggatgaaga 3060

agaaggtgat tgtgaagaag aagagtttga gccatcaact caatatgagt atggtactga 3120

agatgattac caaggtaaac ctttggaatt tggtgccact tctgctgctc ttcaacctga 3180

agaagagcaa gaagaagatt ggttagatga tgatagtcaa caaactgttg gtcaacaaga 3240

cggcagtgag gacaatcaga caactactat tcaaacaatt gttgaggttc aacctcaatt 3300

agagatggaa cttacaccag ttgttcagac tattgaagtg aatagtttta gtggttattt 3360

aaaacttact gacaatgtat acattaaaaa tgcagacatt gtggaagaag ctaaaaaggt 3420

aaaaccaaca gtggttgtta atgcagccaa tgtttacctt aaacatggag gaggtgttgc 3480

aggagcctta aataaggcta ctaacaatgc catgcaagtt gaatctgatg attacatagc 3540

tactaatgga ccacttaaag tgggtggtag ttgtgtttta agcggacaca atcttgctaa 3600

acactgtctt catgttgtcg gcccaaatgt taacaaaggt gaagacattc aacttcttaa 3660

gagtgcttat gaaaatttta atcagcacga agttctactt gcaccattat tatcagctgg 3720

tatttttggt gctgacccta tacattcttt aagagtttgt gtagatactg ttcgcacaaa 3780

tgtctactta gctgtctttg ataaaaatct ctatgacaaa cttgtttcaa gctttttgga 3840

aatgaagagt gaaaagcaag ttgaacaaaa gatcgctgag attcctaaag aggaagttaa 3900

gccatttata actgaaagta aaccttcagt tgaacagaga aaacaagatg ataagaaaat 3960

caaagcttgt gttgaagaag ttacaacaac tctggaagaa actaagttcc tcacagaaaa 4020

cttgttactt tatattgaca ttaatggcaa tcttcatcca gattctgcca ctcttgttag 4080

tgacattgac atcactttct taaagaaaga tgctccatat atagtgggtg atgttgttca 4140

agagggtgtt ttaactgctg tggttatacc tactaaaaag gctggtggca ctactgaaat 4200

gctagcgaaa gctttgagaa aagtgccaac agacaattat ataaccactt acccgggtca 4260

gggtttaaat ggttacactg tagaggaggc aaagacagtg cttaaaaagt gtaaaagtgc 4320

cttttacatt ctaccatcta ttatctctaa tgagaagcaa gaaattcttg gaactgtttc 4380

ttggaatttg cgagaaatgc ttgcacatgc agaagaaaca cgcaaattaa tgcctgtctg 4440

tgtggaaact aaagccatag tttcaactat acagcgtaaa tataagggta ttaaaataca 4500

agagggtgtg gttgattatg gtgctagatt ttacttttac accagtaaaa caactgtagc 4560

gtcacttatc aacacactta acgatctaaa tgaaactctt gttacaatgc cacttggcta 4620

tgtaacacat ggcttaaatt tggaagaagc tgctcggtat atgagatctc tcaaagtgcc 4680

agctacagtt tctgtttctt cacctgatgc tgttacagcg tataatggtt atcttacttc 4740

ttcttctaaa acacctgaag aacattttat tgaaaccatc tcacttgctg gttcctataa 4800

agattggtcc tattctggac aatctacaca actaggtata gaatttctta agagaggtga 4860

taaaagtgta tattacacta gtaatcctac cacattccac ctagatggtg aagttatcac 4920

ctttgacaat cttaagacac ttctttcttt gagagaagtg aggactatta aggtgtttac 4980

aacagtagac aacattaacc tccacacgca agttgtggac atgtcaatga catatggaca 5040

acagtttggt ccaacttatt tggatggagc tgatgttact aaaataaaac ctcataattc 5100

acatgaaggt aaaacatttt atgttttacc taatgatgac actctacgtg ttgaggcttt 5160

tgagtactac cacacaactg atcctagttt tctgggtagg tacatgtcag cattaaatca 5220

cactaaaaag tggaaatacc cacaagttaa tggtttaact tctattaaat gggcagataa 5280

caactgttat cttgccactg cattgttaac actccaacaa atagagttga agtttaatcc 5340

acctgctcta caagatgctt attacagagc aagggctggt gaagctgcta acttttgtgc 5400

acttatctta gcctactgta ataagacagt aggtgagtta ggtgatgtta gagaaacaat 5460

gagttacttg tttcaacatg ccaatttaga ttcttgcaaa agagtcttga acgtggtgtg 5520

taaaacttgt ggacaacagc agacaaccct taagggtgta gaagctgtta tgtacatggg 5580

cacactttct tatgaacaat ttaagaaagg tgttcagata ccttgtacgt gtggtaaaca 5640

agctacaaaa tatctagtac aacaggagtc accttttgtt atgatgtcag caccacctgc 5700

tcagtatgaa cttaagcatg gtacatttac ttgtgctagt gagtacactg gtaattacca 5760

gtgtggtcac tataaacata taacttctaa agaaactttg tattgcatag acggtgcttt 5820

acttacaaag tcctcagaat acaaaggtcc tattacggat gttttctaca aagaaaacag 5880

ttacacaaca accataaaac cagttactta taaattggat ggtgttgttt gtacagaaat 5940

tgaccctaag ttggacaatt attataagaa agacaattct tatttcacag agcaaccaat 6000

tgatcttgta ccaaaccaac catatccaaa cgcaagcttc gataatttta agtttgtatg 6060

tgataatatc aaatttgctg atgatttaaa ccagttaact ggttataaga aacctgcttc 6120

aagagagctt aaagttacat ttttccctga cttaaatggt gatgtggtgg ctattgatta 6180

taaacactac acaccctctt ttaagaaagg agctaaattg ttacataaac ctattgtttg 6240

gcatgttaac aatgcaacta ataaagccac gtataaacca aatacctggt gtatacgttg 6300

tctttggagc acaaaaccag ttgaaacatc aaattcgttt gatgtactga agtcagagga 6360

cgcgcaggga atggataatc ttgcctgcga agatctaaaa ccagtctctg aagaagtagt 6420

ggaaaatcct accatacaga aagacgttct tgagtgtaat gtgaaaacta ccgaagttgt 6480

aggagacatt atacttaaac cagcaaataa tagtttaaaa attacagaag aggttggcca 6540

cacagatcta atggctgctt atgtagacaa ttctagtctt actattaaga aacctaatga 6600

attatctaga gtattaggtt tgaaaaccct tgctactcat ggtttagctg ctgttaatag 6660

tgtcccttgg gatactatag ctaattatgc taagcctttt cttaacaaag ttgttagtac 6720

aactactaac atagttacac ggtgtttaaa ccgtgtttgt actaattata tgccttattt 6780

ctttacttta ttgctacaat tgtgtacttt tactagaagt acaaattcta gaattaaagc 6840

atctatgccg actactatag caaagaatac tgttaagagt gtcggtaaat tttgtctaga 6900

ggcttcattt aattatttga agtcacctaa tttttctaaa ctgataaata ttataatttg 6960

gtttttacta ttaagtgttt gcctaggttc tttaatctac tcaaccgctg ctttaggtgt 7020

tttaatgtct aatttaggca tgccttctta ctgtactggt tacagagaag gctatttgaa 7080

ctctactaat gtcactattg caacctactg tactggttct ataccttgta gtgtttgtct 7140

tagtggttta gattctttag acacctatcc ttctttagaa actatacaaa ttaccatttc 7200

atcttttaaa tgggatttaa ctgcttttgg cttagttgca gagtggtttt tggcatatat 7260

tcttttcact aggtttttct atgtacttgg attggctgca atcatgcaat tgtttttcag 7320

ctattttgca gtacatttta ttagtaattc ttggcttatg tggttaataa ttaatcttgt 7380

acaaatggcc ccgatttcag ctatggttag aatgtacatc ttctttgcat cattttatta 7440

tgtatggaaa agttatgtgc atgttgtaga cggttgtaat tcatcaactt gtatgatgtg 7500

ttacaaacgt aatagagcaa caagagtcga atgtacaact attgttaatg gtgttagaag 7560

gtccttttat gtctatgcta atggaggtaa aggcttttgc aaactacaca attggaattg 7620

tgttaattgt gatacattct gtgctggtag tacatttatt agtgatgaag ttgcgagaga 7680

cttgtcacta cagtttaaaa gaccaataaa tcctactgac cagtcttctt acatcgttga 7740

tagtgttaca gtgaagaatg gttccatcca tctttacttt gataaagctg gtcaaaagac 7800

ttatgaaaga cattctctct ctcattttgt taacttagac aacctgagag ctaataacac 7860

taaaggttca ttgcctatta atgttatagt ttttgatggt aaatcaaaat gtgaagaatc 7920

atctgcaaaa tcagcgtctg tttactacag tcagcttatg tgtcaaccta tactgttact 7980

agatcaggca ttagtgtctg atgttggtga tagtgcggaa gttgcagtta aaatgtttga 8040

tgcttacgtt aatacgtttt catcaacttt taacgtacca atggaaaaac tcaaaacact 8100

agttgcaact gcagaagctg aacttgcaaa gaatgtgtcc ttagacaatg tcttatctac 8160

ttttatttca gcagctcggc aagggtttgt tgattcagat gtagaaacta aagatgttgt 8220

tgaatgtctt aaattgtcac atcaatctga catagaagtt actggcgata gttgtaataa 8280

ctatatgctc acctataaca aagttgaaaa catgacaccc cgtgaccttg gtgcttgtat 8340

tgactgtagt gcgcgtcata ttaatgcgca ggtagcaaaa agtcacaaca ttgctttgat 8400

atggaacgtt aaagatttca tgtcattgtc tgaacaacta cgaaaacaaa tacgtagtgc 8460

tgctaaaaag aataacttac cttttaagtt gacatgtgca actactagac aagttgttaa 8520

tgttgtaaca acaaagatag cacttaaggg tggtaaaatt gttaataatt ggttgaagca 8580

gttaattaaa gttacacttg tgttcctttt tgttgctgct attttctatt taataacacc 8640

tgttcatgtc atgtctaaac atactgactt ttcaagtgaa atcataggat acaaggctat 8700

tgatggtggt gtcactcgtg acatagcatc tacagatact tgttttgcta acaaacatgc 8760

tgattttgac acatggttta gccagcgtgg tggtagttat actaatgaca aagcttgccc 8820

attgattgct gcagtcataa caagagaagt gggttttgtc gtgcctggtt tgcctggcac 8880

gatattacgc acaactaatg gtgacttttt gcatttctta cctagagttt ttagtgcagt 8940

tggtaacatc tgttacacac catcaaaact tatagagtac actgactttg caacatcagc 9000

ttgtgttttg gctgctgaat gtacaatttt taaagatgct tctggtaagc cagtaccata 9060

ttgttatgat accaatgtac tagaaggttc tgttgcttat gaaagtttac gccctgacac 9120

acgttatgtg ctcatggatg gctctattat tcaatttcct aacacctacc ttgaaggttc 9180

tgttagagtg gtaacaactt ttgattctga gtactgtagg cacggcactt gtgaaagatc 9240

agaagctggt gtttgtgtat ctactagtgg tagatgggta cttaacaatg attattacag 9300

atctttacca ggagttttct gtggtgtaga tgctgtaaat ttacttacta atatgtttac 9360

accactaatt caacctattg gtgctttgga catatcagca tctatagtag ctggtggtat 9420

tgtagctatc gtagtaacat gccttgccta ctattttatg aggtttagaa gagcttttgg 9480

tgaatacagt catgtagttg cctttaatac tttactattc cttatgtcat tcactgtact 9540

ctgtttaaca ccagtttact cattcttacc tggtgtttat tctgttattt acttgtactt 9600

gacattttat cttactaatg atgtttcttt tttagcacat attcagtgga tggttatgtt 9660

cacaccttta gtacctttct ggataacaat tgcttatatc atttgtattt ccacaaagca 9720

tttctattgg ttctttagta attacctaaa gagacgtgta gtctttaatg gtgtttcctt 9780

tagtactttt gaagaagctg cgctgtgcac ctttttgtta aataaagaaa tgtatctaaa 9840

gttgcgtagt gatgtgctat tacctcttac gcaatataat agatacttag ctctttataa 9900

taagtacaag tattttagtg gagcaatgga tacaactagc tacagagaag ctgcttgttg 9960

tcatctcgca aaggctctca atgacttcag taactcaggt tctgatgttc tttaccaacc 10020

accacaaacc tctatcacct cagctgtttt gcagagtggt tttagaaaaa tggcattccc 10080

atctggtaaa gttgagggtt gtatggtaca agtaacttgt ggtacaacta cacttaacgg 10140

tctttggctt gatgacgtag tttactgtcc aagacatgtg atctgcacct ctgaagacat 10200

gcttaaccct aattatgaag atttactcat tcgtaagtct aatcataatt tcttggtaca 10260

ggctggtaat gttcaactca gggttattgg acattctatg caaaattgtg tacttaagct 10320

taaggttgat acagccaatc ctaagacacc taagtataag tttgttcgca ttcaaccagg 10380

acagactttt tcagtgttag cttgttacaa tggttcacca tctggtgttt accaatgtgc 10440

tatgaggccc aatttcacta ttaagggttc attccttaat ggttcatgtg gtagtgttgg 10500

ttttaacata gattatgact gtgtctcttt ttgttacatg caccatatgg aattaccaac 10560

tggagttcat gctggcacag acttagaagg taacttttat ggaccttttg ttgacaggca 10620

aacagcacaa gcagctggta cggacacaac tattacagtt aatgttttag cttggttgta 10680

cgctgctgtt ataaatggag acaggtggtt tctcaatcga tttaccacaa ctcttaatga 10740

ctttaacctt gtggctatga agtacaatta tgaacctcta acacaagacc atgttgacat 10800

actaggacct ctttctgctc aaactggaat tgccgtttta gatatgtgtg cttcattaaa 10860

agaattactg caaaatggta tgaatggacg taccatattg ggtagtgctt tattagaaga 10920

tgaatttaca ccttttgatg ttgttagaca atgctcaggt gttactttcc aaagtgcagt 10980

gaaaagaaca atcaagggta cacaccactg gttgttactc acaattttga cttcactttt 11040

agttttagtc cagagtactc aatggtcttt gttctttttt ttgtatgaaa atgccttttt 11100

accttttgct atgggtatta ttgctatgtc tgcttttgca atgatgtttg tcaaacataa 11160

gcatgcattt ctctgtttgt ttttgttacc ttctcttgcc actgtagctt attttaatat 11220

ggtctatatg cctgctagtt gggtgatgcg tattatgaca tggttggata tggttgatac 11280

tagtttgtct ggttttaagc taaaagactg tgttatgtat gcatcagctg tagtgttact 11340

aatccttatg acagcaagaa ctgtgtatga tgatggtgct aggagagtgt ggacacttat 11400

gaatgtcttg acactcgttt ataaagttta ttatggtaat gctttagatc aagccatttc 11460

catgtgggct cttataatct ctgttacttc taactactca ggtgtagtta caactgtcat 11520

gtttttggcc agaggtattg tttttatgtg tgttgagtat tgccctattt tcttcataac 11580

tggtaataca cttcagtgta taatgctagt ttattgtttc ttaggctatt tttgtacttg 11640

ttactttggc ctcttttgtt tactcaaccg ctactttaga ctgactcttg gtgtttatga 11700

ttacttagtt tctacacagg agtttagata tatgaattca cagggactac tcccacccaa 11760

gaatagcata gatgccttca aactcaacat taaattgttg ggtgttggtg gcaaaccttg 11820

tatcaaagta gccactgtac agtctaaaat gtcagatgta aagtgcacat cagtagtctt 11880

actctcagtt ttgcaacaac tcagagtaga atcatcatct aaattgtggg ctcaatgtgt 11940

ccagttacac aatgacattc tcttagctaa agatactact gaagcctttg aaaaaatggt 12000

ttcactactt tctgttttgc tttccatgca gggtgctgta gacataaaca agctttgtga 12060

agaaatgctg gacaacaggg caaccttaca agctatagcc tcagagttta gttcccttcc 12120

atcatatgca gcttttgcta ctgctcaaga agcttatgag caggctgttg ctaatggtga 12180

ttctgaagtt gttcttaaaa agttgaagaa gtctttgaat gtggctaaat ctgaatttga 12240

ccgtgatgca gccatgcaac gtaagttgga aaagatggct gatcaagcta tgacccaaat 12300

gtataaacag gctagatctg aggacaagag ggcaaaagtt actagtgcta tgcagacaat 12360

gcttttcact atgcttagaa agttggataa tgatgcactc aacaacatta tcaacaatgc 12420

aagagatggt tgtgttccct tgaacataat acctcttaca acagcagcca aactaatggt 12480

tgtcatacca gactataaca catataaaaa tacgtgtgat ggtacaacat ttacttatgc 12540

atcagcattg tgggaaatcc aacaggttgt agatgcagat agtaaaattg ttcaacttag 12600

tgaaattagt atggacaatt cacctaattt agcatggcct cttattgtaa cagctttaag 12660

ggccaattct gctgtcaaat tacagaataa tgagcttagt cctgttgcac tacgacagat 12720

gtcttgtgct gccggtacta cacaaactgc ttgcactgat gacaatgcgt tagcttacta 12780

caacacaaca aagggaggta ggtttgtact tgcactgtta tccgatttac aggatttgaa 12840

atgggctaga ttccctaaga gtgatggaac tggtactatc tatacagaac tggaaccacc 12900

ttgtaggttt gttacagaca cacctaaagg tcctaaagtg aagtatttat actttattaa 12960

aggattaaac aacctaaata gaggtatggt acttggtagt ttagctgcca cagtacgtct 13020

acaagctggt aatgcaacag aagtgcctgc caattcaact gtattatctt tctgtgcttt 13080

tgctgtagat gctgctaaag cttacaaaga ttatctagct agtgggggac aaccaatcac 13140

taattgtgtt aagatgttgt gtacacacac tggtactggt caggcaataa cagttacacc 13200

ggaagccaat atggatcaag aatcctttgg tggtgcatcg tgttgtctgt actgccgttg 13260

ccacatagat catccaaatc ctaaaggatt ttgtgactta aaaggtaagt atgtacaaat 13320

acctacaact tgtgctaatg accctgtggg ttttacactt aaaaacacag tctgtaccgt 13380

ctgcggtatg tggaaaggtt atggctgtag ttgtgatcaa ctccgcgaac ccatgcttca 13440

gtcagctgat gcacaatcgt ttttaaacgg gtttgcggtg taagtgcagc ccgtcttaca 13500

ccgtgcggca caggcactag tactgatgtc gtatacaggg cttttgacat ctacaatgat 13560

aaagtagctg gttttgctaa attcctaaaa actaattgtt gtcgcttcca agaaaaggac 13620

gaagatgaca atttaattga ttcttacttt gtagttaaga gacacacttt ctctaactac 13680

caacatgaag aaacaattta taatttactt aaggattgtc cagctgttgc taaacatgac 13740

ttctttaagt ttagaataga cggtgacatg gtaccacata tatcacgtca acgtcttact 13800

aaatacacaa tggcagacct cgtctatgct ttaaggcatt ttgatgaagg taattgtgac 13860

acattaaaag aaatacttgt cacatacaat tgttgtgatg atgattattt caataaaaag 13920

gactggtatg attttgtaga aaacccagat atattacgcg tatacgccaa cttaggtgaa 13980

cgtgtacgcc aagctttgtt aaaaacagta caattctgtg atgccatgcg aaatgctggt 14040

attgttggtg tactgacatt agataatcaa gatctcaatg gtaactggta tgatttcggt 14100

gatttcatac aaaccacgcc aggtagtgga gttcctgttg tagattctta ttattcattg 14160

ttaatgccta tattaacctt gaccagggct ttaactgcag agtcacatgt tgacactgac 14220

ttaacaaagc cttacattaa gtgggatttg ttaaaatatg acttcacgga agagaggtta 14280

aaactctttg accgttattt taaatattgg gatcagacat accacccaaa ttgtgttaac 14340

tgtttggatg acagatgcat tctgcattgt gcaaacttta atgttttatt ctctacagtg 14400

ttcccaccta caagttttgg accactagtg agaaaaatat ttgttgatgg tgttccattt 14460

gtagtttcaa ctggatacca cttcagagag ctaggtgttg tacataatca ggatgtaaac 14520

ttacatagct ctagacttag ttttaaggaa ttacttgtgt atgctgctga ccctgctatg 14580

cacgctgctt ctggtaatct attactagat aaacgcacta cgtgcttttc agtagctgca 14640

cttactaaca atgttgcttt tcaaactgtc aaacccggta attttaacaa agacttctat 14700

gactttgctg tgtctaaggg tttctttaag gaaggaagtt ctgttgaatt aaaacacttc 14760

ttctttgctc aggatggtaa tgctgctatc agcgattatg actactatcg ttataatcta 14820

ccaacaatgt gtgatatcag acaactacta tttgtagttg aagttgttga taagtacttt 14880

gattgttacg atggtggctg tattaatgct aaccaagtca tcgtcaacaa cctagacaaa 14940

tcagctggtt ttccatttaa taaatggggt aaggctagac tttattatga ttcaatgagt 15000

tatgaggatc aagatgcact tttcgcatat acaaaacgta atgtcatccc tactataact 15060

caaatgaatc ttaagtatgc cattagtgca aagaatagag ctcgcaccgt agctggtgtc 15120

tctatctgta gtactatgac caatagacag tttcatcaaa aattattgaa atcaatagcc 15180

gccactagag gagctactgt agtaattgga acaagcaaat tctatggtgg ttggcacaac 15240

atgttaaaaa ctgtttatag tgatgtagaa aaccctcacc ttatgggttg ggattatcct 15300

aaatgtgata gagccatgcc taacatgctt agaattatgg cctcacttgt tcttgctcgc 15360

aaacatacaa cgtgttgtag cttgtcacac cgtttctata gattagctaa tgagtgtgct 15420

caagtattga gtgaaatggt catgtgtggc ggttcactat atgttaaacc aggtggaacc 15480

tcatcaggag atgccacaac tgcttatgct aatagtgttt ttaacatttg tcaagctgtc 15540

acggccaatg ttaatgcact tttatctact gatggtaaca aaattgccga taagtatgtc 15600

cgcaatttac aacacagact ttatgagtgt ctctatagaa atagagatgt tgacacagac 15660

tttgtgaatg agttttacgc atatttgcgt aaacatttct caatgatgat actctctgac 15720

gatgctgttg tgtgtttcaa tagcacttat gcatctcaag gtctagtggc tagcataaag 15780

aactttaagt cagttcttta ttatcaaaac aatgttttta tgtctgaagc aaaatgttgg 15840

actgagactg accttactaa aggacctcat gaattttgct ctcaacatac aatgctagtt 15900

aaacagggtg atgattatgt gtaccttcct tacccagatc catcaagaat cctaggggcc 15960

ggctgttttg tagatgatat cgtaaaaaca gatggtacac ttatgattga acggttcgtg 16020

tctttagcta tagatgctta cccacttact aaacatccta atcaggagta tgctgatgtc 16080

tttcatttgt acttacaata cataagaaag ctacatgatg agttaacagg acacatgtta 16140

gacatgtatt ctgttatgct tactaatgat aacacttcaa ggtattggga acctgagttt 16200

tatgaggcta tgtacacacc gcatacagtc ttacaggctg ttggggcttg tgttctttgc 16260

aattcacaga cttcattaag atgtggtgct tgcatacgta gaccattctt atgttgtaaa 16320

tgctgttacg accatgtcat atcaacatca cataaattag tcttgtctgt taatccgtat 16380

gtttgcaatg ctccaggttg tgatgtcaca gatgtgactc aactttactt aggaggtatg 16440

agctattatt gtaaatcaca taaaccaccc attagttttc cattgtgtgc taatggacaa 16500

gtttttggtt tatataaaaa tacatgtgtt ggtagcgata atgttactga ctttaatgca 16560

attgcaacat gtgactggac aaatgctggt gattacattt tagctaacac ctgtactgaa 16620

agactcaagc tttttgcagc agaaacgctc aaagctactg aggagacatt taaactgtct 16680

tatggtattg ctactgtacg tgaagtgctg tctgacagag aattacatct ttcatgggaa 16740

gttggtaaac ctagaccacc acttaaccga aattatgtct ttactggtta tcgtgtaact 16800

aaaaacagta aagtacaaat aggagagtac acctttgaaa aaggtgacta tggtgatgct 16860

gttgtttacc gaggtacaac aacttacaaa ttaaatgttg gtgattattt tgtgctgaca 16920

tcacatacag taatgccatt aagtgcacct acactagtgc cacaagagca ctatgttaga 16980

attactggct tatacccaac actcaatatc tcagatgagt tttctagcaa tgttgcaaat 17040

tatcaaaagg ttggtatgca aaagtattct acactccagg gaccacctgg tactggtaag 17100

agtcattttg ctattggcct agctctctac tacccttctg ctcgcatagt gtatacagct 17160

tgctctcatg ccgctgttga tgcactatgt gagaaggcat taaaatattt gcctatagat 17220

aaatgtagta gaattatacc tgcacgtgct cgtgtagagt gttttgataa attcaaagtg 17280

aattcaacat tagaacagta tgtcttttgt actgtaaatg cattgcctga gacgacagca 17340

gatatagttg tctttgatga aatttcaatg gccacaaatt atgatttgag tgttgtcaat 17400

gccagattac gtgctaagca ctatgtgtac attggcgacc ctgctcaatt acctgcacca 17460

cgcacattgc taactaaggg cacactagaa ccagaatatt tcaattcagt gtgtagactt 17520

atgaaaacta taggtccaga catgttcctc ggaacttgtc ggcgttgtcc tgctgaaatt 17580

gttgacactg tgagtgcttt ggtttatgat aataagctta aagcacataa agacaaatca 17640

gctcaatgct ttaaaatgtt ttataagggt gttatcacgc atgatgtttc atctgcaatt 17700

aacaggccac aaataggcgt ggtaagagaa ttccttacac gtaaccctgc ttggagaaaa 17760

gctgtcttta tttcacctta taattcacag aatgctgtag cctcaaagat tttgggacta 17820

ccaactcaaa ctgttgattc atcacagggc tcagaatatg actatgtcat attcactcaa 17880

accactgaaa cagctcactc ttgtaatgta aacagattta atgttgctat taccagagca 17940

aaagtaggca tactttgcat aatgtctgat agagaccttt atgacaagtt gcaatttaca 18000

agtcttgaaa ttccacgtag gaatgtggca actttacaag ctgaaaatgt aacaggactc 18060

tttaaagatt gtagtaaggt aatcactggg ttacatccta cacaggcacc tacacacctc 18120

agtgttgaca ctaaattcaa aactgaaggt ttatgtgttg acatacctgg catacctaag 18180

gacatgacct atagaagact catctctatg atgggtttta aaatgaatta tcaagttaat 18240

ggttacccta acatgtttat cacccgcgaa gaagctataa gacatgtacg tgcatggatt 18300

ggcttcgatg tcgaggggtg tcatgctact agagaagctg ttggtaccaa tttaccttta 18360

cagctaggtt tttctacagg tgttaaccta gttgctgtac ctacaggtta tgttgataca 18420

cctaataata cagatttttc cagagttagt gctaaaccac cgcctggaga tcaatttaaa 18480

cacctcatac cacttatgta caaaggactt ccttggaatg tagtgcgtat aaagattgta 18540

caaatgttaa gtgacacact taaaaatctc tctgacagag tcgtatttgt cttatgggca 18600

catggctttg agttgacatc tatgaagtat tttgtgaaaa taggacctga gcgcacctgt 18660

tgtctatgtg atagacgtgc cacatgcttt tccactgctt cagacactta tgcctgttgg 18720

catcattcta ttggatttga ttacgtctat aatccgttta tgattgatgt tcaacaatgg 18780

ggttttacag gtaacctaca aagcaaccat gatctgtatt gtcaagtcca tggtaatgca 18840

catgtagcta gttgtgatgc aatcatgact aggtgtctag ctgtccacga gtgctttgtt 18900

aagcgtgttg actggactat tgaatatcct ataattggtg atgaactgaa gattaatgcg 18960

gcttgtagaa aggttcaaca catggttgtt aaagctgcat tattagcaga caaattccca 19020

gttcttcacg acattggtaa ccctaaagct attaagtgtg tacctcaagc tgatgtagaa 19080

tggaagttct atgatgcaca gccttgtagt gacaaagctt ataaaataga agaattattc 19140

tattcttatg ccacacattc tgacaaattc acagatggtg tatgcctatt ttggaattgc 19200

aatgtcgata gatatcctgc taattccatt gtttgtagat ttgacactag agtgctatct 19260

aaccttaact tgcctggttg tgatggtggc agtttgtatg taaataaaca tgcattccac 19320

acaccagctt ttgataaaag tgcttttgtt aatttaaaac aattaccatt tttctattac 19380

tctgacagtc catgtgagtc tcatggaaaa caagtagtgt cagatataga ttatgtacca 19440

ctaaagtctg ctacgtgtat aacacgttgc aatttaggtg gtgctgtctg tagacatcat 19500

gctaatgagt acagattgta tctcgatgct tataacatga tgatctcagc tggctttagc 19560

ttgtgggttt acaaacaatt tgatacttat aacctctgga acacttttac aagacttcag 19620

agtttagaaa atgtggcttt taatgttgta aataagggac actttgatgg acaacagggt 19680

gaagtaccag tttctatcat taataacact gtttacacaa aagttgatgg tgttgatgta 19740

gaattgtttg aaaataaaac aacattacct gttaatgtag catttgagct ttgggctaag 19800

cgcaacatta aaccagtacc agaggtgaaa atactcaata atttgggtgt ggacattgct 19860

gctaatactg tgatctggga ctacaaaaga gatgctccag cacatatatc tactattggt 19920

gtttgttcta tgactgacat agccaagaaa ccaactgaaa cgatttgtgc accactcact 19980

gtcttttttg atggtagagt tgatggtcaa gtagacttat ttagaaatgc ccgtaatggt 20040

gttcttatta cagaaggtag tgttaaaggt ttacaaccat ctgtaggtcc caaacaagct 20100

agtcttaatg gagtcacatt aattggagaa gccgtaaaaa cacagttcaa ttattataag 20160

aaagttgatg gtgttgtcca acaattacct gaaacttact ttactcagag tagaaattta 20220

caagaattta aacccaggag tcaaatggaa attgatttct tagaattagc tatggatgaa 20280

ttcattgaac ggtataaatt agaaggctat gccttcgaac atatcgttta tggagatttt 20340

agtcatagtc agttaggtgg tttacatcta ctgattggac tagctaaacg ttttaaggaa 20400

tcaccttttg aattagaaga ttttattcct atggacagta cagttaaaaa ctatttcata 20460

acagatgcgc aaacaggttc atctaagtgt gtgtgttctg ttattgattt attacttgat 20520

gattttgttg aaataataaa atcccaagat ttatctgtag tttctaaggt tgtcaaagtg 20580

actattgact atacagaaat ttcatttatg ctttggtgta aagatggcca tgtagaaaca 20640

ttttacccaa aattacaatc tagtcaagcg tggcaaccgg gtgttgctat gcctaatctt 20700

tacaaaatgc aaagaatgct attagaaaag tgtgaccttc aaaattatgg tgatagtgca 20760

acattaccta aaggcataat gatgaatgtc gcaaaatata ctcaactgtg tcaatattta 20820

aacacattaa cattagctgt accctataat atgagagtta tacattttgg tgctggttct 20880

gataaaggag ttgcaccagg tacagctgtt ttaagacagt ggttgcctac gggtacgctg 20940

cttgtcgatt cagatcttaa tgactttgtc tctgatgcag attcaacttt gattggtgat 21000

tgtgcaactg tacatacagc taataaatgg gatctcatta ttagtgatat gtacgaccct 21060

aagactaaaa atgttacaaa agaaaatgac tctaaagagg gttttttcac ttacatttgt 21120

gggtttatac aacaaaagct agctcttgga ggttccgtgg ctataaagat aacagaacat 21180

tcttggaatg ctgatcttta taagctcatg ggacacttcg catggtggac agcctttgtt 21240

actaatgtga atgcgtcatc atctgaagca tttttaattg gatgtaatta tcttggcaaa 21300

ccacgcgaac aaatagatgg ttatgtcatg catgcaaatt acatattttg gaggaataca 21360

aatccaattc agttgtcttc ctattcttta tttgacatga gtaaatttcc ccttaaatta 21420

aggggtactg ctgttatgtc tttaaaagaa ggtcaaatca atgatatgat tttatctctt 21480

cttagtaaag gtagacttat aattagagaa aacaacagag ttgttatttc tagtgatgtt 21540

cttgttaaca actaaacgaa caatgtttgt ttttcttgtt ttattgccac tagtctctag 21600

tcagtgtgtt aatcttacaa ccagaactca attaccccct gcatacacta attctttcac 21660

acgtggtgtt tattaccctg acaaagtttt cagatcctca gttttacatt caactcagga 21720

cttgttctta cctttctttt ccaatgttac ttggttccat gctatacatg tctctgggac 21780

caatggtact aagaggtttg ataaccctgt cctaccattt aatgatggtg tttattttgc 21840

ttccactgag aagtctaaca taataagagg ctggattttt ggtactactt tagattcgaa 21900

gacccagtcc ctacttattg ttaataacgc tactaatgtt gttattaaag tctgtgaatt 21960

tcaattttgt aatgatccat ttttgggtgt ttattaccac aaaaacaaca aaagttggat 22020

ggaaagtgag ttcagagttt attctagtgc gaataattgc acttttgaat atgtctctca 22080

gccttttctt atggaccttg aaggaaaaca gggtaatttc aaaaatctta gggaatttgt 22140

gtttaagaat attgatggtt attttaaaat atattctaag cacacgccta ttaatttagt 22200

gcgtgatctc cctcagggtt tttcggcttt agaaccattg gtagatttgc caataggtat 22260

taacatcact aggtttcaaa ctttacttgc tttacataga agttatttga ctcctggtga 22320

ttcttcttca ggttggacag ctggtgctgc agcttattat gtgggttatc ttcaacctag 22380

gacttttcta ttaaaatata atgaaaatgg aaccattaca gatgctgtag actgtgcact 22440

tgaccctctc tcagaaacaa agtgtacgtt gaaatccttc actgtagaaa aaggaatcta 22500

tcaaacttct aactttagag tccaaccaac agaatctatt gttagatttc ctaatattac 22560

aaacttgtgc ccttttggtg aagtttttaa cgccaccaga tttgcatctg tttatgcttg 22620

gaacaggaag agaatcagca actgtgttgc tgattattct ttcctatata attccgcatc 22680

attttccact tttaagtgtt atggagtgtc tcctactaaa ttaaatgatc tctgctttac 22740

taatgtctat gcagattcat ttgtaattag aggtgatgaa gtcagacaaa tcgctccagg 22800

gcaaactgga aagattgctg attataatta taaattacca gatgatttta caggctgcgt 22860

tatagcttgg aattctaaca atcttgattc taaggttggt ggtaattata attacctgta 22920

tagattgttt aggaagtcta atctcaaacc ttttgagaga gatatttcaa ctgaaatcta 22980

tcaggccggt agcacacctt gtaatggtgt tgaaggtttt aattgttact ttcctttaca 23040

atcatatggt ttccaaccca ctaatggtgt tggttaccaa ccatacagag tagtagtact 23100

ttcttttgaa cttctacatg caccagcaac tgtttgtgga cctaaaaagt ctactaattt 23160

ggttaaaaac aaatgtgtca atttcaactt caatggttta acaggcacag gtgttcttac 23220

tgagtctaac aaaaagtttc tgcctttcca acaatttggc agagacattg ctgacactac 23280

tgatgctgtc cgtgatccac agacacttga gattcttgac attacaccat gttcttttgg 23340

tggtgtcagt gttataacac caggaacaaa tacttctaac caggttgctg ttctttatca 23400

ggatgttaac tgcacagaag tccctgttgc tattcatgca gatcaactta ctcctacttg 23460

gcgtgtttat tctacaggtt ctaatgtttt tcaaacacgt gcaggctgtt taataggggc 23520

tgaacatgtc aacaactcat atgagtgtga catacccatt ggtgcaggta tatgcgctag 23580

ttatcagact cagactaatt ctcctcggcg ggcacgtagt gtagctagtc aatccatcat 23640

tgcctacact atgtcacttg gtgcagaaaa ttcagttgct tactctaata actctattgc 23700

catacccaca aattttacta ttagtgttac cacagaaatt ctaccagtgt ctatgaccaa 23760

gacatcagta gattgtacaa tgtacatttg tggtgattca actgaatgca gcaatctttt 23820

gttgcaatat ggcagttttt gtacacaatt aaaccgtgct ttaactggaa tagctgttga 23880

acaagacaaa aacacccaag aagtttttgc acaagtcaaa caaatttaca aaacaccacc 23940

aattaaagat tttggtggtt ttaatttttc acaaatatta ccagatccat caaaaccaag 24000

caagaggtca tttattgaag atctactttt caacaaagtg acacttgcag atgctggctt 24060

catcaaacaa tatggtgatt gccttggtga tattgctgct agagacctca tttgtgcaca 24120

aaagtttaac ggccttactg ttttgccacc tttgctcaca gatgaaatga ttgctcaata 24180

cacttctgca ctgttagcgg gtacaatcac ttctggttgg acctttggtg caggtgctgc 24240

attacaaata ccatttgcta tgcaaatggc ttataggttt aatggtattg gagttacaca 24300

gaatgttctc tatgagaacc aaaaattgat tgccaaccaa tttaatagtg ctattggcaa 24360

aattcaagac tcactttctt ccacagcaag tgcacttgga aaacttcaag atgtggtcaa 24420

ccaaaatgca caagctttaa acacgcttgt taaacaactt agctccaatt ttggtgcaat 24480

ttcaagtgtt ttaaatgata tcctttcacg tcttgacaaa gttgaggctg aagtgcaaat 24540

tgataggttg atcacaggca gacttcaaag tttgcagaca tatgtgactc aacaattaat 24600

tagagctgca gaaatcagag cttctgctaa tcttgctgct actaaaatgt cagagtgtgt 24660

acttggacaa tcaaaaagag ttgatttttg tggaaagggc tatcatctta tgtccttccc 24720

tcagtcagca cctcatggtg tagtcttctt gcatgtgact tatgtccctg cacaagaaaa 24780

gaacttcaca actgctcctg ccatttgtca tgatggaaaa gcacactttc ctcgtgaagg 24840

tgtctttgtt tcaaatggca cacactggtt tgtaacacaa aggaattttt atgaaccaca 24900

aatcattact acagacaaca catttgtgtc tggtaactgt gatgttgtaa taggaattgt 24960

caacaacaca gtttatgatc ctttgcaacc tgaattagac tcattcaagg aggagttaga 25020

taaatatttt aagaatcata catcaccaga tgttgattta ggtgacatct ctggcattaa 25080

tgcttcagtt gtaaacattc aaaaagaaat tgaccgcctc aatgaggttg ccaagaattt 25140

aaatgaatct ctcatcgatc tccaagaact tggaaagtat gagcagtata taaaatggcc 25200

atggtacatt tggctaggtt ttatagctgg cttgattgcc atagtaatgg tgacaattat 25260

gctttgctgt atgaccagtt gctgtagttg tctcaagggc tgttgttctt gtggatcctg 25320

ctgcaaattt gatgaagacg actctgagcc agtgctcaaa ggagtcaaat tacattacac 25380

ataaacgaac ttatggattt gtttatgaga atcttcacaa ttggaactgt aactttgaag 25440

caaggtgaaa tcaaggatgc tactccttca gattttgttc gcgctactgc aacgataccg 25500

atacaagcct cactcccttt cggatggctt attgttggcg ttgcacttct tgctgttttt 25560

cagagcgctt ccaaaatcat aaccctcaaa aagagatggc aactagcact ctccaagggt 25620

gttcactttg tttgcaactt gctgttgttg tttgtaacag tttactcaca ccttttgctc 25680

gttgctgctg gccttgaagc cccttttctc tatctttatg ctttagtcta cttcttgcag 25740

agtataaact ttgtaagaat aataatgagg ctttggcttt gctggaaatg ccgttccaaa 25800

aacccattac tttatgatgc caactatttt ctttgctggc atactaattg ttacgactat 25860

tgtatacctt acaatagtgt aacttcttca attgtcatta cttcaggtga tggcacaaca 25920

agtcctattt ctgaacatga ctaccagatt ggtggttata ctgaaaaatg ggaatctgga 25980

gtaaaagact gtgttgtatt acacagttac ttcacttcag actattacca gctgtactca 26040

actcaattga gtacagacac tggtgttgaa catgttacct tcttcatcta caataaaatt 26100

gttgatgagc ctgaagaaca tgtccaaatt cacacaatcg acgtttcatc cggagttgtt 26160

aatccagtaa tggaaccaat ttatgatgaa ccgacgacga ctactagcgt gcctttgtaa 26220

gcacaagctg atgagtacga acttatgtac tcattcgttt cggaagagac aggtacgtta 26280

atagttaata gcgtacttct ttttcttgct ttcgtggtat tcttgctagt tacactagcc 26340

atccttactg cgcttcgatt gtgtgcgtac tgctgcaata ttgttaacgt gagtcttgta 26400

aaaccttctt tttacgttta ctctcgtgtt aaaaatctga attcttctag agttcctgat 26460

cttctggtct aaacgaacta aatattatat tagtttttct gtttggaact ttaattttag 26520

ccatggcaga ttccaacggt actattaccg ttgaagagct taaaaagctc cttgaacaat 26580

ggaacctagt aataggtttc ctattcctta catggatttg tcttctacaa tttgcctatg 26640

ccaacaggaa taggtttttg tatataatta agttaatttt cctctggctg ttatggccag 26700

taactttagc ttgttttgtg cttgctgctg tttacagaat aaattggatc accggtggaa 26760

ttgctatcgc aatggcttgt cttgtaggct tgatgtggct cagctacttc attgcttctt 26820

tcagactgtt tgcgcgtacg cgttccatgt ggtcattcaa tccagaaact aacattcttc 26880

tcaacgtgcc actccatggc actattctga ccagaccgct tctagaaagt gaactcgtaa 26940

tcggagctgt gatccttcgt ggacatcttc gtattgctgg acaccatcta ggacgctgtg 27000

acatcaagga cctgcctaaa gaaatcactg ttgctacatc acgaacgctt tcttattaca 27060

aattgggagc ttcgcagcgt gtagcaggtg actcaggttt tgctgcatac agtcgctaca 27120

ggattggcaa ctataaatta aacacagacc attccagtag cagtgacaat attgctttgc 27180

ttgtacagta agtgacaaca gatgtttcat ctcgttgact ttcaggttac tatagcagag 27240

atattactaa ttattatgag gacttttaaa gtttccattt ggaatcttga ttacatcata 27300

aacctcataa ttaaaaattt atctaagtca ctaactgaga ataaatattc tcaattagat 27360

gaagagcaac caatggagat tgattaaacg aacatgaaaa ttattctttt cttggcactg 27420

ataacactcg ctacttgtga gctttatcac taccaagagt gtgttagagg tacaacagta 27480

cttttaaaag aaccttgctc ttctggaaca tacgagggca attcaccatt tcatcctcta 27540

gctgataaca aatttgcact gacttgcttt agcactcaat ttgcttttgc ttgtcctgac 27600

ggcgtaaaac acgtctatca gttacgtgcc agatcagttt cacctaaact gttcatcaga 27660

caagaggaag ttcaagaact ttactctcca atttttctta ttgttgcggc aatagtgttt 27720

ataacacttt gcttcacact caaaagaaag acagaatgat tgaactttca ttaattgact 27780

tctatttgtg ctttttagcc tttctgctat tccttgtttt aattatgctt attatctttt 27840

ggttctcact tgaactgcaa gatcataatg aaacttgtca cgcctaaacg aacatgaaat 27900

ttcttgtttt cttaggaatc atcacaactg tagctgcatt tcaccaagaa tgtagtttac 27960

agtcatgtac tcaacatcaa ccatatgtag ttgatgaccc gtgtcctatt cacttctatt 28020

ctaaatggta tattagagta ggagctagaa aatcagcacc tttaattgaa ttgtgcgtgg 28080

atgaggctgg ttctaaatca cccattcagt acatcgatat cggtaattat acagtttcct 28140

gtttaccttt tacaattaat tgccaggaac ctaaattggg tagtcttgta gtgcgttgtt 28200

cgttctatga agacttttta gagtatcatg acgttcgtgt tgttttagat ttcatctaaa 28260

cgaacaaact aaaatgtctg ataatggacc ccaaaatcag cgaaatgcac cccgcattac 28320

gtttggtgga ccctcagatt caactggcag taaccagaat ggagaacgca gtggggcgcg 28380

atcaaaacaa cgtcggcccc aaggtttacc caataatact gcgtcttggt tcaccgctct 28440

cactcaacat ggcaaggaag accttaaatt ccctcgagga caaggcgttc caattaacac 28500

caatagcagt ccagatgacc aaattggcta ctaccgaaga gctaccagac gaattcgtgg 28560

tggtgacggt aaaatgaaag atctcagtcc aagatggtat ttctactacc taggaactgg 28620

gccagaagct ggacttccct atggtgctaa caaagacggc atcatatggg ttgcaactga 28680

gggagccttg aatacaccaa aagatcacat tggcacccgc aatcctgcta acaatgctgc 28740

aatcgtgcta caacttcctc aaggaacaac attgccaaaa ggcttctacg cagaagggag 28800

cagaggcggc agtcaagcct cttctcgttc ctcatcacgt agtcgcaaca gttcaagaaa 28860

ttcaactcca ggcagcagta ggggaacttc tcctgctaga atggctggca atggcggtga 28920

tgctgctctt gctttgctgc tgcttgacag attgaaccag cttgagagca aaatgtctgg 28980

taaaggccaa caacaacaag gccaaactgt cactaagaaa tctgctgctg aggcttctaa 29040

gaagcctcgg caaaaacgta ctgccactaa agcatacaat gtaacacaag ctttcggcag 29100

acgtggtcca gaacaaaccc aaggaaattt tggggaccag gaactaatca gacaaggaac 29160

tgattacaaa cattggccgc aaattgcaca atttgccccc agcgcttcag cgttcttcgg 29220

aatgtcgcgc attggcatgg aagtcacacc ttcgggaacg tggttgacct acacaggtgc 29280

catcaaattg gatgacaaag atccaaattt caaagatcaa gtcattttgc tgaataagca 29340

tattgacgca tacaaaacat tcccaccaac agagcctaaa aaggacaaaa agaagaaggc 29400

tgatgaaact caagccttac cgcagagaca gaagaaacag caaactgtga ctcttcttcc 29460

tgctgcagat ttggatgatt tctccaaaca attgcaacaa tccatgagca gtgctgactc 29520

aactcaggcc taaactcatg cagaccacac aaggcagatg ggctatataa acgttttcgc 29580

ttttccgttt acgatatata gtctactctt gtgcagaatg aattctcgta actacatagc 29640

acaagtagat gtagttaact ttaatctcac atagcaatct ttaatcagtg tgtaacatta 29700

gggaggactt gaaagagcca ccacattttc accgaggcca cgcggagtac gatcgagtgt 29760

acagtgaaca atgctaggga gagctgccta tatggaagag ccctaatgtg taaaattaat 29820

tttagtagtg ctatccccat gtgattttaa tagcttctta ggagaatgac aaaa 29874

<210> 13

<211> 4405

<212> PRT

<213> SARS-CoV2

<400> 13

Met Glu Ser Leu Val Pro Gly Phe Asn Glu Lys Thr His Val Gln Leu

1 5 10 15

Ser Leu Pro Val Leu Gln Val Arg Asp Val Leu Val Arg Gly Phe Gly

20 25 30

Asp Ser Val Glu Glu Val Leu Ser Glu Ala Arg Gln His Leu Lys Asp

35 40 45

Gly Thr Cys Gly Leu Val Glu Val Glu Lys Gly Val Leu Pro Gln Leu

50 55 60

Glu Gln Pro Tyr Val Phe Ile Lys Arg Ser Asp Ala Arg Thr Ala Pro

65 70 75 80

His Gly His Val Met Val Glu Leu Val Ala Glu Leu Glu Gly Ile Gln

85 90 95

Tyr Gly Arg Ser Gly Glu Thr Leu Gly Val Leu Val Pro His Val Gly

100 105 110

Glu Ile Pro Val Ala Tyr Arg Lys Val Leu Leu Arg Lys Asn Gly Asn

115 120 125

Lys Gly Ala Gly Gly His Ser Tyr Gly Ala Asp Leu Lys Ser Phe Asp

130 135 140

Leu Gly Asp Glu Leu Gly Thr Asp Pro Tyr Glu Asp Phe Gln Glu Asn

145 150 155 160

Trp Asn Thr Lys His Ser Ser Gly Val Thr Arg Glu Leu Met Arg Glu

165 170 175

Leu Asn Gly Gly Ala Tyr Thr Arg Tyr Val Asp Asn Asn Phe Cys Gly

180 185 190

Pro Asp Gly Tyr Pro Leu Glu Cys Ile Lys Asp Leu Leu Ala Arg Ala

195 200 205

Gly Lys Ala Ser Cys Thr Leu Ser Glu Gln Leu Asp Phe Ile Asp Thr

210 215 220

Lys Arg Gly Val Tyr Cys Cys Arg Glu His Glu His Glu Ile Ala Trp

225 230 235 240

Tyr Thr Glu Arg Ser Glu Lys Ser Tyr Glu Leu Gln Thr Pro Phe Glu

245 250 255

Ile Lys Leu Ala Lys Lys Phe Asp Thr Phe Asn Gly Glu Cys Pro Asn

260 265 270

Phe Val Phe Pro Leu Asn Ser Ile Ile Lys Thr Ile Gln Pro Arg Val

275 280 285

Glu Lys Lys Lys Leu Asp Gly Phe Met Gly Arg Ile Arg Ser Val Tyr

290 295 300

Pro Val Ala Ser Pro Asn Glu Cys Asn Gln Met Cys Leu Ser Thr Leu

305 310 315 320

Met Lys Cys Asp His Cys Gly Glu Thr Ser Trp Gln Thr Gly Asp Phe

325 330 335

Val Lys Ala Thr Cys Glu Phe Cys Gly Thr Glu Asn Leu Thr Lys Glu

340 345 350

Gly Ala Thr Thr Cys Gly Tyr Leu Pro Gln Asn Ala Val Val Lys Ile

355 360 365

Tyr Cys Pro Ala Cys His Asn Ser Glu Val Gly Pro Glu His Ser Leu

370 375 380

Ala Glu Tyr His Asn Glu Ser Gly Leu Lys Thr Ile Leu Arg Lys Gly

385 390 395 400

Gly Arg Thr Ile Ala Phe Gly Gly Cys Val Phe Ser Tyr Val Gly Cys

405 410 415

His Asn Lys Cys Ala Tyr Trp Val Pro Arg Ala Ser Ala Asn Ile Gly

420 425 430

Cys Asn His Thr Gly Val Val Gly Glu Gly Ser Glu Gly Leu Asn Asp

435 440 445

Asn Leu Leu Glu Ile Leu Gln Lys Glu Lys Val Asn Ile Asn Ile Val

450 455 460

Gly Asp Phe Lys Leu Asn Glu Glu Ile Ala Ile Ile Leu Ala Ser Phe

465 470 475 480

Ser Ala Ser Thr Ser Ala Phe Val Glu Thr Val Lys Gly Leu Asp Tyr

485 490 495

Lys Ala Phe Lys Gln Ile Val Glu Ser Cys Gly Asn Phe Lys Val Thr

500 505 510

Lys Gly Lys Ala Lys Lys Gly Ala Trp Asn Ile Gly Glu Gln Lys Ser

515 520 525

Ile Leu Ser Pro Leu Tyr Ala Phe Ala Ser Glu Ala Ala Arg Val Val

530 535 540

Arg Ser Ile Phe Ser Arg Thr Leu Glu Thr Ala Gln Asn Ser Val Arg

545 550 555 560

Val Leu Gln Lys Ala Ala Ile Thr Ile Leu Asp Gly Ile Ser Gln Tyr

565 570 575

Ser Leu Arg Leu Ile Asp Ala Met Met Phe Thr Ser Asp Leu Ala Thr

580 585 590

Asn Asn Leu Val Val Met Ala Tyr Ile Thr Gly Gly Val Val Gln Leu

595 600 605

Thr Ser Gln Trp Leu Thr Asn Ile Phe Gly Thr Val Tyr Glu Lys Leu

610 615 620

Lys Pro Val Leu Asp Trp Leu Glu Glu Lys Phe Lys Glu Gly Val Glu

625 630 635 640

Phe Leu Arg Asp Gly Trp Glu Ile Val Lys Phe Ile Ser Thr Cys Ala

645 650 655

Cys Glu Ile Val Gly Gly Gln Ile Val Thr Cys Ala Lys Glu Ile Lys

660 665 670

Glu Ser Val Gln Thr Phe Phe Lys Leu Val Asn Lys Phe Leu Ala Leu

675 680 685

Cys Ala Asp Ser Ile Ile Ile Gly Gly Ala Lys Leu Lys Ala Leu Asn

690 695 700

Leu Gly Glu Thr Phe Val Thr His Ser Lys Gly Leu Tyr Arg Lys Cys

705 710 715 720

Val Lys Ser Arg Glu Glu Thr Gly Leu Leu Met Pro Leu Lys Ala Pro

725 730 735

Lys Glu Ile Ile Phe Leu Glu Gly Glu Thr Leu Pro Thr Glu Val Leu

740 745 750

Thr Glu Glu Val Val Leu Lys Thr Gly Asp Leu Gln Pro Leu Glu Gln

755 760 765

Pro Thr Ser Glu Ala Val Glu Ala Pro Leu Val Gly Thr Pro Val Cys

770 775 780

Ile Asn Gly Leu Met Leu Leu Glu Ile Lys Asp Thr Glu Lys Tyr Cys

785 790 795 800

Ala Leu Ala Pro Asn Met Met Val Thr Asn Asn Thr Phe Thr Leu Lys

805 810 815

Gly Gly Ala Pro Thr Lys Val Thr Phe Gly Asp Asp Thr Val Ile Glu

820 825 830

Val Gln Gly Tyr Lys Ser Val Asn Ile Thr Phe Glu Leu Asp Glu Arg

835 840 845

Ile Asp Lys Val Leu Asn Glu Lys Cys Ser Ala Tyr Thr Val Glu Leu

850 855 860

Gly Thr Glu Val Asn Glu Phe Ala Cys Val Val Ala Asp Ala Val Ile

865 870 875 880

Lys Thr Leu Gln Pro Val Ser Glu Leu Leu Thr Pro Leu Gly Ile Asp

885 890 895

Leu Asp Glu Trp Ser Met Ala Thr Tyr Tyr Leu Phe Asp Glu Ser Gly

900 905 910

Glu Phe Lys Leu Ala Ser His Met Tyr Cys Ser Phe Tyr Pro Pro Asp

915 920 925

Glu Asp Glu Glu Glu Gly Asp Cys Glu Glu Glu Glu Phe Glu Pro Ser

930 935 940

Thr Gln Tyr Glu Tyr Gly Thr Glu Asp Asp Tyr Gln Gly Lys Pro Leu

945 950 955 960

Glu Phe Gly Ala Thr Ser Ala Ala Leu Gln Pro Glu Glu Glu Gln Glu

965 970 975

Glu Asp Trp Leu Asp Asp Asp Ser Gln Gln Thr Val Gly Gln Gln Asp

980 985 990

Gly Ser Glu Asp Asn Gln Thr Thr Thr Ile Gln Thr Ile Val Glu Val

995 1000 1005

Gln Pro Gln Leu Glu Met Glu Leu Thr Pro Val Val Gln Thr Ile

1010 1015 1020

Glu Val Asn Ser Phe Ser Gly Tyr Leu Lys Leu Thr Asp Asn Val

1025 1030 1035

Tyr Ile Lys Asn Ala Asp Ile Val Glu Glu Ala Lys Lys Val Lys

1040 1045 1050

Pro Thr Val Val Val Asn Ala Ala Asn Val Tyr Leu Lys His Gly

1055 1060 1065

Gly Gly Val Ala Gly Ala Leu Asn Lys Ala Thr Asn Asn Ala Met

1070 1075 1080

Gln Val Glu Ser Asp Asp Tyr Ile Ala Thr Asn Gly Pro Leu Lys

1085 1090 1095

Val Gly Gly Ser Cys Val Leu Ser Gly His Asn Leu Ala Lys His

1100 1105 1110

Cys Leu His Val Val Gly Pro Asn Val Asn Lys Gly Glu Asp Ile

1115 1120 1125

Gln Leu Leu Lys Ser Ala Tyr Glu Asn Phe Asn Gln His Glu Val

1130 1135 1140

Leu Leu Ala Pro Leu Leu Ser Ala Gly Ile Phe Gly Ala Asp Pro

1145 1150 1155

Ile His Ser Leu Arg Val Cys Val Asp Thr Val Arg Thr Asn Val

1160 1165 1170

Tyr Leu Ala Val Phe Asp Lys Asn Leu Tyr Asp Lys Leu Val Ser

1175 1180 1185

Ser Phe Leu Glu Met Lys Ser Glu Lys Gln Val Glu Gln Lys Ile

1190 1195 1200

Ala Glu Ile Pro Lys Glu Glu Val Lys Pro Phe Ile Thr Glu Ser

1205 1210 1215

Lys Pro Ser Val Glu Gln Arg Lys Gln Asp Asp Lys Lys Ile Lys

1220 1225 1230

Ala Cys Val Glu Glu Val Thr Thr Thr Leu Glu Glu Thr Lys Phe

1235 1240 1245

Leu Thr Glu Asn Leu Leu Leu Tyr Ile Asp Ile Asn Gly Asn Leu

1250 1255 1260

His Pro Asp Ser Ala Thr Leu Val Ser Asp Ile Asp Ile Thr Phe

1265 1270 1275

Leu Lys Lys Asp Ala Pro Tyr Ile Val Gly Asp Val Val Gln Glu

1280 1285 1290

Gly Val Leu Thr Ala Val Val Ile Pro Thr Lys Lys Ala Gly Gly

1295 1300 1305

Thr Thr Glu Met Leu Ala Lys Ala Leu Arg Lys Val Pro Thr Asp

1310 1315 1320

Asn Tyr Ile Thr Thr Tyr Pro Gly Gln Gly Leu Asn Gly Tyr Thr

1325 1330 1335

Val Glu Glu Ala Lys Thr Val Leu Lys Lys Cys Lys Ser Ala Phe

1340 1345 1350

Tyr Ile Leu Pro Ser Ile Ile Ser Asn Glu Lys Gln Glu Ile Leu

1355 1360 1365

Gly Thr Val Ser Trp Asn Leu Arg Glu Met Leu Ala His Ala Glu

1370 1375 1380

Glu Thr Arg Lys Leu Met Pro Val Cys Val Glu Thr Lys Ala Ile

1385 1390 1395

Val Ser Thr Ile Gln Arg Lys Tyr Lys Gly Ile Lys Ile Gln Glu

1400 1405 1410

Gly Val Val Asp Tyr Gly Ala Arg Phe Tyr Phe Tyr Thr Ser Lys

1415 1420 1425

Thr Thr Val Ala Ser Leu Ile Asn Thr Leu Asn Asp Leu Asn Glu

1430 1435 1440

Thr Leu Val Thr Met Pro Leu Gly Tyr Val Thr His Gly Leu Asn

1445 1450 1455

Leu Glu Glu Ala Ala Arg Tyr Met Arg Ser Leu Lys Val Pro Ala

1460 1465 1470

Thr Val Ser Val Ser Ser Pro Asp Ala Val Thr Ala Tyr Asn Gly

1475 1480 1485

Tyr Leu Thr Ser Ser Ser Lys Thr Pro Glu Glu His Phe Ile Glu

1490 1495 1500

Thr Ile Ser Leu Ala Gly Ser Tyr Lys Asp Trp Ser Tyr Ser Gly

1505 1510 1515

Gln Ser Thr Gln Leu Gly Ile Glu Phe Leu Lys Arg Gly Asp Lys

1520 1525 1530

Ser Val Tyr Tyr Thr Ser Asn Pro Thr Thr Phe His Leu Asp Gly

1535 1540 1545

Glu Val Ile Thr Phe Asp Asn Leu Lys Thr Leu Leu Ser Leu Arg

1550 1555 1560

Glu Val Arg Thr Ile Lys Val Phe Thr Thr Val Asp Asn Ile Asn

1565 1570 1575

Leu His Thr Gln Val Val Asp Met Ser Met Thr Tyr Gly Gln Gln

1580 1585 1590

Phe Gly Pro Thr Tyr Leu Asp Gly Ala Asp Val Thr Lys Ile Lys

1595 1600 1605

Pro His Asn Ser His Glu Gly Lys Thr Phe Tyr Val Leu Pro Asn

1610 1615 1620

Asp Asp Thr Leu Arg Val Glu Ala Phe Glu Tyr Tyr His Thr Thr

1625 1630 1635

Asp Pro Ser Phe Leu Gly Arg Tyr Met Ser Ala Leu Asn His Thr

1640 1645 1650

Lys Lys Trp Lys Tyr Pro Gln Val Asn Gly Leu Thr Ser Ile Lys

1655 1660 1665

Trp Ala Asp Asn Asn Cys Tyr Leu Ala Thr Ala Leu Leu Thr Leu

1670 1675 1680

Gln Gln Ile Glu Leu Lys Phe Asn Pro Pro Ala Leu Gln Asp Ala

1685 1690 1695

Tyr Tyr Arg Ala Arg Ala Gly Glu Ala Ala Asn Phe Cys Ala Leu

1700 1705 1710

Ile Leu Ala Tyr Cys Asn Lys Thr Val Gly Glu Leu Gly Asp Val

1715 1720 1725

Arg Glu Thr Met Ser Tyr Leu Phe Gln His Ala Asn Leu Asp Ser

1730 1735 1740

Cys Lys Arg Val Leu Asn Val Val Cys Lys Thr Cys Gly Gln Gln

1745 1750 1755

Gln Thr Thr Leu Lys Gly Val Glu Ala Val Met Tyr Met Gly Thr

1760 1765 1770

Leu Ser Tyr Glu Gln Phe Lys Lys Gly Val Gln Ile Pro Cys Thr

1775 1780 1785

Cys Gly Lys Gln Ala Thr Lys Tyr Leu Val Gln Gln Glu Ser Pro

1790 1795 1800

Phe Val Met Met Ser Ala Pro Pro Ala Gln Tyr Glu Leu Lys His

1805 1810 1815

Gly Thr Phe Thr Cys Ala Ser Glu Tyr Thr Gly Asn Tyr Gln Cys

1820 1825 1830

Gly His Tyr Lys His Ile Thr Ser Lys Glu Thr Leu Tyr Cys Ile

1835 1840 1845

Asp Gly Ala Leu Leu Thr Lys Ser Ser Glu Tyr Lys Gly Pro Ile

1850 1855 1860

Thr Asp Val Phe Tyr Lys Glu Asn Ser Tyr Thr Thr Thr Ile Lys

1865 1870 1875

Pro Val Thr Tyr Lys Leu Asp Gly Val Val Cys Thr Glu Ile Asp

1880 1885 1890

Pro Lys Leu Asp Asn Tyr Tyr Lys Lys Asp Asn Ser Tyr Phe Thr

1895 1900 1905

Glu Gln Pro Ile Asp Leu Val Pro Asn Gln Pro Tyr Pro Asn Ala

1910 1915 1920

Ser Phe Asp Asn Phe Lys Phe Val Cys Asp Asn Ile Lys Phe Ala

1925 1930 1935

Asp Asp Leu Asn Gln Leu Thr Gly Tyr Lys Lys Pro Ala Ser Arg

1940 1945 1950

Glu Leu Lys Val Thr Phe Phe Pro Asp Leu Asn Gly Asp Val Val

1955 1960 1965

Ala Ile Asp Tyr Lys His Tyr Thr Pro Ser Phe Lys Lys Gly Ala

1970 1975 1980

Lys Leu Leu His Lys Pro Ile Val Trp His Val Asn Asn Ala Thr

1985 1990 1995

Asn Lys Ala Thr Tyr Lys Pro Asn Thr Trp Cys Ile Arg Cys Leu

2000 2005 2010

Trp Ser Thr Lys Pro Val Glu Thr Ser Asn Ser Phe Asp Val Leu

2015 2020 2025

Lys Ser Glu Asp Ala Gln Gly Met Asp Asn Leu Ala Cys Glu Asp

2030 2035 2040

Leu Lys Pro Val Ser Glu Glu Val Val Glu Asn Pro Thr Ile Gln

2045 2050 2055

Lys Asp Val Leu Glu Cys Asn Val Lys Thr Thr Glu Val Val Gly

2060 2065 2070

Asp Ile Ile Leu Lys Pro Ala Asn Asn Ser Leu Lys Ile Thr Glu

2075 2080 2085

Glu Val Gly His Thr Asp Leu Met Ala Ala Tyr Val Asp Asn Ser

2090 2095 2100

Ser Leu Thr Ile Lys Lys Pro Asn Glu Leu Ser Arg Val Leu Gly

2105 2110 2115

Leu Lys Thr Leu Ala Thr His Gly Leu Ala Ala Val Asn Ser Val

2120 2125 2130

Pro Trp Asp Thr Ile Ala Asn Tyr Ala Lys Pro Phe Leu Asn Lys

2135 2140 2145

Val Val Ser Thr Thr Thr Asn Ile Val Thr Arg Cys Leu Asn Arg

2150 2155 2160

Val Cys Thr Asn Tyr Met Pro Tyr Phe Phe Thr Leu Leu Leu Gln

2165 2170 2175

Leu Cys Thr Phe Thr Arg Ser Thr Asn Ser Arg Ile Lys Ala Ser

2180 2185 2190

Met Pro Thr Thr Ile Ala Lys Asn Thr Val Lys Ser Val Gly Lys

2195 2200 2205

Phe Cys Leu Glu Ala Ser Phe Asn Tyr Leu Lys Ser Pro Asn Phe

2210 2215 2220

Ser Lys Leu Ile Asn Ile Ile Ile Trp Phe Leu Leu Leu Ser Val

2225 2230 2235

Cys Leu Gly Ser Leu Ile Tyr Ser Thr Ala Ala Leu Gly Val Leu

2240 2245 2250

Met Ser Asn Leu Gly Met Pro Ser Tyr Cys Thr Gly Tyr Arg Glu

2255 2260 2265

Gly Tyr Leu Asn Ser Thr Asn Val Thr Ile Ala Thr Tyr Cys Thr

2270 2275 2280

Gly Ser Ile Pro Cys Ser Val Cys Leu Ser Gly Leu Asp Ser Leu

2285 2290 2295

Asp Thr Tyr Pro Ser Leu Glu Thr Ile Gln Ile Thr Ile Ser Ser

2300 2305 2310

Phe Lys Trp Asp Leu Thr Ala Phe Gly Leu Val Ala Glu Trp Phe

2315 2320 2325

Leu Ala Tyr Ile Leu Phe Thr Arg Phe Phe Tyr Val Leu Gly Leu

2330 2335 2340

Ala Ala Ile Met Gln Leu Phe Phe Ser Tyr Phe Ala Val His Phe

2345 2350 2355

Ile Ser Asn Ser Trp Leu Met Trp Leu Ile Ile Asn Leu Val Gln

2360 2365 2370

Met Ala Pro Ile Ser Ala Met Val Arg Met Tyr Ile Phe Phe Ala

2375 2380 2385

Ser Phe Tyr Tyr Val Trp Lys Ser Tyr Val His Val Val Asp Gly

2390 2395 2400

Cys Asn Ser Ser Thr Cys Met Met Cys Tyr Lys Arg Asn Arg Ala

2405 2410 2415

Thr Arg Val Glu Cys Thr Thr Ile Val Asn Gly Val Arg Arg Ser

2420 2425 2430

Phe Tyr Val Tyr Ala Asn Gly Gly Lys Gly Phe Cys Lys Leu His

2435 2440 2445

Asn Trp Asn Cys Val Asn Cys Asp Thr Phe Cys Ala Gly Ser Thr

2450 2455 2460

Phe Ile Ser Asp Glu Val Ala Arg Asp Leu Ser Leu Gln Phe Lys

2465 2470 2475

Arg Pro Ile Asn Pro Thr Asp Gln Ser Ser Tyr Ile Val Asp Ser

2480 2485 2490

Val Thr Val Lys Asn Gly Ser Ile His Leu Tyr Phe Asp Lys Ala

2495 2500 2505

Gly Gln Lys Thr Tyr Glu Arg His Ser Leu Ser His Phe Val Asn

2510 2515 2520

Leu Asp Asn Leu Arg Ala Asn Asn Thr Lys Gly Ser Leu Pro Ile

2525 2530 2535

Asn Val Ile Val Phe Asp Gly Lys Ser Lys Cys Glu Glu Ser Ser

2540 2545 2550

Ala Lys Ser Ala Ser Val Tyr Tyr Ser Gln Leu Met Cys Gln Pro

2555 2560 2565

Ile Leu Leu Leu Asp Gln Ala Leu Val Ser Asp Val Gly Asp Ser

2570 2575 2580

Ala Glu Val Ala Val Lys Met Phe Asp Ala Tyr Val Asn Thr Phe

2585 2590 2595

Ser Ser Thr Phe Asn Val Pro Met Glu Lys Leu Lys Thr Leu Val

2600 2605 2610

Ala Thr Ala Glu Ala Glu Leu Ala Lys Asn Val Ser Leu Asp Asn

2615 2620 2625

Val Leu Ser Thr Phe Ile Ser Ala Ala Arg Gln Gly Phe Val Asp

2630 2635 2640

Ser Asp Val Glu Thr Lys Asp Val Val Glu Cys Leu Lys Leu Ser

2645 2650 2655

His Gln Ser Asp Ile Glu Val Thr Gly Asp Ser Cys Asn Asn Tyr

2660 2665 2670

Met Leu Thr Tyr Asn Lys Val Glu Asn Met Thr Pro Arg Asp Leu

2675 2680 2685

Gly Ala Cys Ile Asp Cys Ser Ala Arg His Ile Asn Ala Gln Val

2690 2695 2700

Ala Lys Ser His Asn Ile Ala Leu Ile Trp Asn Val Lys Asp Phe

2705 2710 2715

Met Ser Leu Ser Glu Gln Leu Arg Lys Gln Ile Arg Ser Ala Ala

2720 2725 2730

Lys Lys Asn Asn Leu Pro Phe Lys Leu Thr Cys Ala Thr Thr Arg

2735 2740 2745

Gln Val Val Asn Val Val Thr Thr Lys Ile Ala Leu Lys Gly Gly

2750 2755 2760

Lys Ile Val Asn Asn Trp Leu Lys Gln Leu Ile Lys Val Thr Leu

2765 2770 2775

Val Phe Leu Phe Val Ala Ala Ile Phe Tyr Leu Ile Thr Pro Val

2780 2785 2790

His Val Met Ser Lys His Thr Asp Phe Ser Ser Glu Ile Ile Gly

2795 2800 2805

Tyr Lys Ala Ile Asp Gly Gly Val Thr Arg Asp Ile Ala Ser Thr

2810 2815 2820

Asp Thr Cys Phe Ala Asn Lys His Ala Asp Phe Asp Thr Trp Phe

2825 2830 2835

Ser Gln Arg Gly Gly Ser Tyr Thr Asn Asp Lys Ala Cys Pro Leu

2840 2845 2850

Ile Ala Ala Val Ile Thr Arg Glu Val Gly Phe Val Val Pro Gly

2855 2860 2865

Leu Pro Gly Thr Ile Leu Arg Thr Thr Asn Gly Asp Phe Leu His

2870 2875 2880

Phe Leu Pro Arg Val Phe Ser Ala Val Gly Asn Ile Cys Tyr Thr

2885 2890 2895

Pro Ser Lys Leu Ile Glu Tyr Thr Asp Phe Ala Thr Ser Ala Cys

2900 2905 2910

Val Leu Ala Ala Glu Cys Thr Ile Phe Lys Asp Ala Ser Gly Lys

2915 2920 2925

Pro Val Pro Tyr Cys Tyr Asp Thr Asn Val Leu Glu Gly Ser Val

2930 2935 2940

Ala Tyr Glu Ser Leu Arg Pro Asp Thr Arg Tyr Val Leu Met Asp

2945 2950 2955

Gly Ser Ile Ile Gln Phe Pro Asn Thr Tyr Leu Glu Gly Ser Val

2960 2965 2970

Arg Val Val Thr Thr Phe Asp Ser Glu Tyr Cys Arg His Gly Thr

2975 2980 2985

Cys Glu Arg Ser Glu Ala Gly Val Cys Val Ser Thr Ser Gly Arg

2990 2995 3000

Trp Val Leu Asn Asn Asp Tyr Tyr Arg Ser Leu Pro Gly Val Phe

3005 3010 3015

Cys Gly Val Asp Ala Val Asn Leu Leu Thr Asn Met Phe Thr Pro

3020 3025 3030

Leu Ile Gln Pro Ile Gly Ala Leu Asp Ile Ser Ala Ser Ile Val

3035 3040 3045

Ala Gly Gly Ile Val Ala Ile Val Val Thr Cys Leu Ala Tyr Tyr

3050 3055 3060

Phe Met Arg Phe Arg Arg Ala Phe Gly Glu Tyr Ser His Val Val

3065 3070 3075

Ala Phe Asn Thr Leu Leu Phe Leu Met Ser Phe Thr Val Leu Cys

3080 3085 3090

Leu Thr Pro Val Tyr Ser Phe Leu Pro Gly Val Tyr Ser Val Ile

3095 3100 3105

Tyr Leu Tyr Leu Thr Phe Tyr Leu Thr Asn Asp Val Ser Phe Leu

3110 3115 3120

Ala His Ile Gln Trp Met Val Met Phe Thr Pro Leu Val Pro Phe

3125 3130 3135

Trp Ile Thr Ile Ala Tyr Ile Ile Cys Ile Ser Thr Lys His Phe

3140 3145 3150

Tyr Trp Phe Phe Ser Asn Tyr Leu Lys Arg Arg Val Val Phe Asn

3155 3160 3165

Gly Val Ser Phe Ser Thr Phe Glu Glu Ala Ala Leu Cys Thr Phe

3170 3175 3180

Leu Leu Asn Lys Glu Met Tyr Leu Lys Leu Arg Ser Asp Val Leu

3185 3190 3195

Leu Pro Leu Thr Gln Tyr Asn Arg Tyr Leu Ala Leu Tyr Asn Lys

3200 3205 3210

Tyr Lys Tyr Phe Ser Gly Ala Met Asp Thr Thr Ser Tyr Arg Glu

3215 3220 3225

Ala Ala Cys Cys His Leu Ala Lys Ala Leu Asn Asp Phe Ser Asn

3230 3235 3240

Ser Gly Ser Asp Val Leu Tyr Gln Pro Pro Gln Thr Ser Ile Thr

3245 3250 3255

Ser Ala Val Leu Gln Ser Gly Phe Arg Lys Met Ala Phe Pro Ser

3260 3265 3270

Gly Lys Val Glu Gly Cys Met Val Gln Val Thr Cys Gly Thr Thr

3275 3280 3285

Thr Leu Asn Gly Leu Trp Leu Asp Asp Val Val Tyr Cys Pro Arg

3290 3295 3300

His Val Ile Cys Thr Ser Glu Asp Met Leu Asn Pro Asn Tyr Glu

3305 3310 3315

Asp Leu Leu Ile Arg Lys Ser Asn His Asn Phe Leu Val Gln Ala

3320 3325 3330

Gly Asn Val Gln Leu Arg Val Ile Gly His Ser Met Gln Asn Cys

3335 3340 3345

Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro Lys Thr Pro Lys

3350 3355 3360

Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Phe Ser Val Leu

3365 3370 3375

Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys Ala Met

3380 3385 3390

Arg Pro Asn Phe Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser Cys

3395 3400 3405

Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys

3410 3415 3420

Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr

3425 3430 3435

Asp Leu Glu Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr

3440 3445 3450

Ala Gln Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu

3455 3460 3465

Ala Trp Leu Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu

3470 3475 3480

Asn Arg Phe Thr Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met

3485 3490 3495

Lys Tyr Asn Tyr Glu Pro Leu Thr Gln Asp His Val Asp Ile Leu

3500 3505 3510

Gly Pro Leu Ser Ala Gln Thr Gly Ile Ala Val Leu Asp Met Cys

3515 3520 3525

Ala Ser Leu Lys Glu Leu Leu Gln Asn Gly Met Asn Gly Arg Thr

3530 3535 3540

Ile Leu Gly Ser Ala Leu Leu Glu Asp Glu Phe Thr Pro Phe Asp

3545 3550 3555

Val Val Arg Gln Cys Ser Gly Val Thr Phe Gln Ser Ala Val Lys

3560 3565 3570

Arg Thr Ile Lys Gly Thr His His Trp Leu Leu Leu Thr Ile Leu

3575 3580 3585

Thr Ser Leu Leu Val Leu Val Gln Ser Thr Gln Trp Ser Leu Phe

3590 3595 3600

Phe Phe Leu Tyr Glu Asn Ala Phe Leu Pro Phe Ala Met Gly Ile

3605 3610 3615

Ile Ala Met Ser Ala Phe Ala Met Met Phe Val Lys His Lys His

3620 3625 3630

Ala Phe Leu Cys Leu Phe Leu Leu Pro Ser Leu Ala Thr Val Ala

3635 3640 3645

Tyr Phe Asn Met Val Tyr Met Pro Ala Ser Trp Val Met Arg Ile

3650 3655 3660

Met Thr Trp Leu Asp Met Val Asp Thr Ser Leu Ser Gly Phe Lys

3665 3670 3675

Leu Lys Asp Cys Val Met Tyr Ala Ser Ala Val Val Leu Leu Ile

3680 3685 3690

Leu Met Thr Ala Arg Thr Val Tyr Asp Asp Gly Ala Arg Arg Val

3695 3700 3705

Trp Thr Leu Met Asn Val Leu Thr Leu Val Tyr Lys Val Tyr Tyr

3710 3715 3720

Gly Asn Ala Leu Asp Gln Ala Ile Ser Met Trp Ala Leu Ile Ile

3725 3730 3735

Ser Val Thr Ser Asn Tyr Ser Gly Val Val Thr Thr Val Met Phe

3740 3745 3750

Leu Ala Arg Gly Ile Val Phe Met Cys Val Glu Tyr Cys Pro Ile

3755 3760 3765

Phe Phe Ile Thr Gly Asn Thr Leu Gln Cys Ile Met Leu Val Tyr

3770 3775 3780

Cys Phe Leu Gly Tyr Phe Cys Thr Cys Tyr Phe Gly Leu Phe Cys

3785 3790 3795

Leu Leu Asn Arg Tyr Phe Arg Leu Thr Leu Gly Val Tyr Asp Tyr

3800 3805 3810

Leu Val Ser Thr Gln Glu Phe Arg Tyr Met Asn Ser Gln Gly Leu

3815 3820 3825

Leu Pro Pro Lys Asn Ser Ile Asp Ala Phe Lys Leu Asn Ile Lys

3830 3835 3840

Leu Leu Gly Val Gly Gly Lys Pro Cys Ile Lys Val Ala Thr Val

3845 3850 3855

Gln Ser Lys Met Ser Asp Val Lys Cys Thr Ser Val Val Leu Leu

3860 3865 3870

Ser Val Leu Gln Gln Leu Arg Val Glu Ser Ser Ser Lys Leu Trp

3875 3880 3885

Ala Gln Cys Val Gln Leu His Asn Asp Ile Leu Leu Ala Lys Asp

3890 3895 3900

Thr Thr Glu Ala Phe Glu Lys Met Val Ser Leu Leu Ser Val Leu

3905 3910 3915

Leu Ser Met Gln Gly Ala Val Asp Ile Asn Lys Leu Cys Glu Glu

3920 3925 3930

Met Leu Asp Asn Arg Ala Thr Leu Gln Ala Ile Ala Ser Glu Phe

3935 3940 3945

Ser Ser Leu Pro Ser Tyr Ala Ala Phe Ala Thr Ala Gln Glu Ala

3950 3955 3960

Tyr Glu Gln Ala Val Ala Asn Gly Asp Ser Glu Val Val Leu Lys

3965 3970 3975

Lys Leu Lys Lys Ser Leu Asn Val Ala Lys Ser Glu Phe Asp Arg

3980 3985 3990

Asp Ala Ala Met Gln Arg Lys Leu Glu Lys Met Ala Asp Gln Ala

3995 4000 4005

Met Thr Gln Met Tyr Lys Gln Ala Arg Ser Glu Asp Lys Arg Ala

4010 4015 4020

Lys Val Thr Ser Ala Met Gln Thr Met Leu Phe Thr Met Leu Arg

4025 4030 4035

Lys Leu Asp Asn Asp Ala Leu Asn Asn Ile Ile Asn Asn Ala Arg

4040 4045 4050

Asp Gly Cys Val Pro Leu Asn Ile Ile Pro Leu Thr Thr Ala Ala

4055 4060 4065

Lys Leu Met Val Val Ile Pro Asp Tyr Asn Thr Tyr Lys Asn Thr

4070 4075 4080

Cys Asp Gly Thr Thr Phe Thr Tyr Ala Ser Ala Leu Trp Glu Ile

4085 4090 4095

Gln Gln Val Val Asp Ala Asp Ser Lys Ile Val Gln Leu Ser Glu

4100 4105 4110

Ile Ser Met Asp Asn Ser Pro Asn Leu Ala Trp Pro Leu Ile Val

4115 4120 4125

Thr Ala Leu Arg Ala Asn Ser Ala Val Lys Leu Gln Asn Asn Glu

4130 4135 4140

Leu Ser Pro Val Ala Leu Arg Gln Met Ser Cys Ala Ala Gly Thr

4145 4150 4155

Thr Gln Thr Ala Cys Thr Asp Asp Asn Ala Leu Ala Tyr Tyr Asn

4160 4165 4170

Thr Thr Lys Gly Gly Arg Phe Val Leu Ala Leu Leu Ser Asp Leu

4175 4180 4185

Gln Asp Leu Lys Trp Ala Arg Phe Pro Lys Ser Asp Gly Thr Gly

4190 4195 4200

Thr Ile Tyr Thr Glu Leu Glu Pro Pro Cys Arg Phe Val Thr Asp

4205 4210 4215

Thr Pro Lys Gly Pro Lys Val Lys Tyr Leu Tyr Phe Ile Lys Gly

4220 4225 4230

Leu Asn Asn Leu Asn Arg Gly Met Val Leu Gly Ser Leu Ala Ala

4235 4240 4245

Thr Val Arg Leu Gln Ala Gly Asn Ala Thr Glu Val Pro Ala Asn

4250 4255 4260

Ser Thr Val Leu Ser Phe Cys Ala Phe Ala Val Asp Ala Ala Lys

4265 4270 4275

Ala Tyr Lys Asp Tyr Leu Ala Ser Gly Gly Gln Pro Ile Thr Asn

4280 4285 4290

Cys Val Lys Met Leu Cys Thr His Thr Gly Thr Gly Gln Ala Ile

4295 4300 4305

Thr Val Thr Pro Glu Ala Asn Met Asp Gln Glu Ser Phe Gly Gly

4310 4315 4320

Ala Ser Cys Cys Leu Tyr Cys Arg Cys His Ile Asp His Pro Asn

4325 4330 4335

Pro Lys Gly Phe Cys Asp Leu Lys Gly Lys Tyr Val Gln Ile Pro

4340 4345 4350

Thr Thr Cys Ala Asn Asp Pro Val Gly Phe Thr Leu Lys Asn Thr

4355 4360 4365

Val Cys Thr Val Cys Gly Met Trp Lys Gly Tyr Gly Cys Ser Cys

4370 4375 4380

Asp Gln Leu Arg Glu Pro Met Leu Gln Ser Ala Asp Ala Gln Ser

4385 4390 4395

Phe Leu Asn Gly Phe Ala Val

4400 4405

<210> 14

<211> 1273

<212> PRT

<213> SARS-CoV2

<400> 14

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val

1 5 10 15

Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe

20 25 30

Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu

35 40 45

His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp

50 55 60

Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp

65 70 75 80

Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu

85 90 95

Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser

100 105 110

Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile

115 120 125

Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr

130 135 140

Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr

145 150 155 160

Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu

165 170 175

Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe

180 185 190

Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr

195 200 205

Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu

210 215 220

Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr

225 230 235 240

Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser

245 250 255

Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro

260 265 270

Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala

275 280 285

Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys

290 295 300

Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val

305 310 315 320

Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys

325 330 335

Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala

340 345 350

Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Phe Leu

355 360 365

Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro

370 375 380

Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe

385 390 395 400

Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly

405 410 415

Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys

420 425 430

Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn

435 440 445

Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe

450 455 460

Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys

465 470 475 480

Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly

485 490 495

Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val

500 505 510

Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys

515 520 525

Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn

530 535 540

Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu

545 550 555 560

Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val

565 570 575

Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe

580 585 590

Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val

595 600 605

Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile

610 615 620

His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser

625 630 635 640

Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val

645 650 655

Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala

660 665 670

Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala

675 680 685

Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser

690 695 700

Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile

705 710 715 720

Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val

725 730 735

Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu

740 745 750

Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr

755 760 765

Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln

770 775 780

Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe

785 790 795 800

Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser

805 810 815

Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly

820 825 830

Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp

835 840 845

Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu

850 855 860

Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly

865 870 875 880

Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile

885 890 895

Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr

900 905 910

Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn

915 920 925

Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala

930 935 940

Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn

945 950 955 960

Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val

965 970 975

Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln

980 985 990

Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val

995 1000 1005

Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn

1010 1015 1020

Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys

1025 1030 1035

Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro

1040 1045 1050

Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val

1055 1060 1065

Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His

1070 1075 1080

Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn

1085 1090 1095

Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln

1100 1105 1110

Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val

1115 1120 1125

Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro

1130 1135 1140

Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn

1145 1150 1155

His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn

1160 1165 1170

Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu

1175 1180 1185

Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu

1190 1195 1200

Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu

1205 1210 1215

Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met

1220 1225 1230

Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys

1235 1240 1245

Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro

1250 1255 1260

Val Leu Lys Gly Val Lys Leu His Tyr Thr

1265 1270

<210> 15

<211> 29885

<212> DNA

<213> SARS-CoV2

<220>

<221> misc_feature

<222> (1)..(30)

<223> n is a, c, g or t

<220>

<221> misc_feature

<222> (29865)..(29865)

<223> n is a, c, g or t

<220>

<221> misc_feature

<222> (29872)..(29885)

<223> n is a, c, g or t

<400> 15

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn accaaccaac tttcgatctc ttgtagatct 60

gttctctaaa cgaactttaa aatctgtgtg gctgtcactc ggctgcatgc ttagtgcact 120

cacgcagtat aattaataac taattactgt cgttgacagg acacgagtaa ctcgtctatc 180

ttctgcaggc tgcttacggt ttcgtccgtg ttgcagccga tcatcagcac atctaggttt 240

tgtccgggtg tgaccgaaag gtaagatgga gagccttgtc cctggtttca acgagaaaac 300

acacgtccaa ctcagtttgc ctgttttaca ggttcgcgac gtgctcgtac gtggctttgg 360

agactccgtg gaggaggtct tatcagaggc acgtcaacat cttaaagatg gcacttgtgg 420

cttagtagaa gttgaaaaag gcgttttgcc tcaacttgaa cagccctatg tgttcatcaa 480

acgttcggat gctcgaactg cacctcatgg tcatgttatg gttgagctgg tagcagaact 540

cgaaggcatt cagtacggtc gtagtggtga gacacttggt gtccttgtcc ctcatgtggg 600

cgaaatacca gtggcttacc gcaaggttct tcttcgtaag aacggtaata aaggagctgg 660

tggccatagt tacggcgccg atctaaagtc atttgactta ggcgacgagc ttggcactga 720

tccttatgaa gattttcaag aaaactggaa cactaaacat agcagtggtg ttacccgtga 780

actcatgcgt gagcttaacg gaggggcata cactcgctat gtcgataaca acttctgtgg 840

ccctgatggc taccctcttg agtgcattaa agaccttcta gcacgtgctg gtaaagcttc 900

atgcactttg tccgaacaac tggactttat tgacactaag aggggtgtat actgctgccg 960

tgaacatgag catgaaattg cttggtacac ggaacgttct gaaaagagct atgaattgca 1020

gacacctttt gaaattaaat tggcaaagaa atttgacacc ttcaatgggg aatgtccaaa 1080

ttttgtattt cccttaaatt ccataatcaa gactattcaa ccaagggttg aaaagaaaaa 1140

gcttgatggc tttatgggta gaattcgatc tgtctatcca gttgcgtcac caaatgaatg 1200

caaccaaatg tgcctttcaa ctctcatgaa gtgtgatcat tgtggtgaaa cttcatggca 1260

gacgggcgat tttgttaaag ccacttgcga attttgtggc actgagaatt tgactaaaga 1320

aggtgccact acttgtggtt acttacccca aaatgctgtt gttaaaattt attgtccagc 1380

atgtcacaat tcagaagtag gacctgagca tagtcttgcc gaataccata atgaatctgg 1440

cttgaaaacc attcttcgta agggtggtcg cactattgcc tttggaggct gtgtgttctc 1500

ttatgttggt tgccataaca agtgtgccta ttgggttcca cgtgctagcg ctaacatagg 1560

ttgtaaccat acaggtgttg ttggagaagg ttccgaaggt cttaatgaca accttcttga 1620

aatactccaa aaagagaaag tcaacatcaa tattgttggt gactttaaac ttaatgaaga 1680

gatcgccatt attttggcat ctttttctgc ttccacaagt gcttttgtgg aaactgtgaa 1740

aggtttggat tataaagcat tcaaacaaat tgttgaatcc tgtggtaatt ttaaagttac 1800

aaaaggaaaa gctaaaaaag gtgcctggaa tattggtgaa cagaaatcaa tactgagtcc 1860

tctttatgca tttgcatcag aggctgctcg tgttgtacga tcaattttct cccgcactct 1920

tgaaactgct caaaattctg tgcgtgtttt acagaaggcc gctataacaa tactagatgg 1980

aatttcacag tattcactga gactcattga tgctatgatg ttcacatctg atttggctac 2040

taacaatcta gttgtaatgg cctacattac aggtggtgtt gttcagttga cttcgcagtg 2100

gctaactaac atctttggca ctgtttatga aaaactcaaa cccgtccttg attggcttga 2160

agagaagttt aaggaaggtg tagagtttct tagagacggt tgggaaattg ttaaatttat 2220

ctcaacctgt gcttgtgaaa ttgtcggtgg acaaattgtc acctgtgcaa aggaaattaa 2280

ggagagtgtt cagacattct ttaagcttgt aaataaattt ttggctttgt gtgctgactc 2340

tatcattatt ggtggagcta aacttaaagc cttgaattta ggtgaaacat ttgtcacgca 2400

ctcaaaggga ttgtacagaa agtgtgttaa atccagagaa gaaactggcc tactcatgcc 2460

tctaaaagcc ccaaaagaaa ttatcttctt agagggagaa acacttccca cagaagtgtt 2520

aacagaggaa gttgtcttga aaactggtga tttacaacca ttagaacaac ctactagtga 2580

agctgttgaa gctccattgg ttggtacacc agtttgtatt aacgggctta tgttgctcga 2640

aatcaaagac acagaaaagt actgtgccct tgcacctaat atgatggtaa caaacaatac 2700

cttcacactc aaaggcggtg caccaacaaa ggttactttt ggtgatgaca ctgtgataga 2760

agtgcaaggt tacaagagtg tgaatatcac ttttgaactt gatgaaagga ttgataaagt 2820

acttaatgag aagtgctctg cctatacagt tgaactcggt acagaagtaa atgagttcgc 2880

ctgtgttgtg gcagatgctg tcataaaaac tttgcaacca gtatctgaat tacttacacc 2940

actgggcatt gatttagatg agtggagtat ggctacatac tacttatttg atgagtctgg 3000

tgagtttaaa ttggcttcac atatgtattg ttctttttac cctccagatg aggatgaaga 3060

agaaggtgat tgtgaagaag aagagtttga gccatcaact caatatgagt atggtactga 3120

agatgattac caaggtaaac ctttggaatt tggtgccact tctgctgctc ttcaacctga 3180

agaagagcaa gaagaagatt ggttagatga tgatagtcaa caaactgttg gtcaacaaga 3240

cggcagtgag gacaatcaga caactactat tcaaacaatt gttgaggttc aacctcaatt 3300

agagatggaa cttacaccag ttgttcagac tattgaagtg aatagtttta gtggttattt 3360

aaaacttact gacaatgtat acattaaaaa tgcagacatt gtggaagaag ctaaaaaggt 3420

aaaaccaaca gtggttgtta atgcagccaa tgtttacctt aaacatggag gaggtgttgc 3480

aggagcctta aataaggcta ctaacaatgc catgcaagtt gaatctgatg attacatagc 3540

tactaatgga ccacttaaag tgggtggtag ttgtgtttta agcggacaca atcttgctaa 3600

acactgtctt catgttgtcg gcccaaatgt taacaaaggt gaagacattc aacttcttaa 3660

gagtgcttat gaaaatttta atcagcacga agttctactt gcaccattat tatcagctgg 3720

tatttttggt gctgacccta tacattcttt aagagtttgt gtagatactg ttcgcacaaa 3780

tgtctactta gctgtctttg ataaaaatct ctatgacaaa cttgtttcaa gctttttgga 3840

aatgaagagt gaaaagcaag ttgaacaaaa gatcgctgag attcctaaag aggaagttaa 3900

gccatttata actgaaagta aaccttcagt tgaacagaga aaacaagatg ataagaaaat 3960

caaagcttgt gttgaagaag ttacaacaac tctggaagaa actaagttcc tcacagaaaa 4020

cttgttactt tatattgaca ttaatggcaa tcttcatcca gattctgcca ctcttgttag 4080

tgacattgac atcactttct taaagaaaga tgctccatat atagtgggtg atgttgttca 4140

agagggtgtt ttaactgctg tggttatacc tactaaaaag gctggtggca ctactgaaat 4200

gctagcgaaa gctttgagaa aagtgccaac agacaattat ataaccactt acccgggtca 4260

gggtttaaat ggttacactg tagaggaggc aaagacagtg cttaaaaagt gtaaaagtgc 4320

cttttacatt ctaccatcta ttatctctaa tgagaagcaa gaaattcttg gaactgtttc 4380

ttggaatttg cgagaaatgc ttgcacatgc agaagaaaca cgcaaattaa tgcctgtctg 4440

tgtggaaact aaagccatag tttcaactat acagcgtaaa tataagggta ttaaaataca 4500

agagggtgtg gttgattatg gtgctagatt ttacttttac accagtaaaa caactgtagc 4560

gtcacttatc aacacactta acgatctaaa tgaaactctt gttacaatgc cacttggcta 4620

tgtaacacat ggcttaaatt tggaagaagc tgctcggtat atgagatctc tcaaagtgcc 4680

agctacagtt tctgtttctt cacctgatgc tgttacagcg tataatggtt atcttacttc 4740

ttcttctaaa acacctgaag aacattttat tgaaaccatc tcacttgctg gttcctataa 4800

agattggtcc tattctggac aatctacaca actaggtata gaatttctta agagaggtga 4860

taaaagtgta tattacacta gtaatcctac cacattccac ctagatggtg aagttatcac 4920

ctttgacaat cttaagacac ttctttcttt gagagaagtg aggactatta aggtgtttac 4980

aacagtagac aacattaacc tccacacgca agttgtggac atgtcaatga catatggaca 5040

acagtttggt ccaacttatt tggatggagc tgatgttact aaaataaaac ctcataattc 5100

acatgaaggt aaaacatttt atgttttacc taatgatgac actctacgtg ttgaggcttt 5160

tgagtactac cacacaactg atcctagttt tctgggtagg tacatgtcag cattaaatca 5220

cactaaaaag tggaaatacc cacaagttaa tggtttaact tctattaaat gggcagataa 5280

caactgttat cttgccactg cattgttaac actccaacaa atagagttga agtttaatcc 5340

acctgctcta caagatgctt attacagagc aagggctggt gaagctgcta acttttgtgc 5400

acttatctta gcctactgta ataagacagt aggtgagtta ggtgatgtta gagaaacaat 5460

gagttacttg tttcaacatg ccaatttaga ttcttgcaaa agagtcttga acgtggtgtg 5520

taaaacttgt ggacaacagc agacaaccct taagggtgta gaagctgtta tgtacatggg 5580

cacactttct tatgaacaat ttaagaaagg tgttcagata ccttgtacgt gtggtaaaca 5640

agctacaaaa tatctagtac aacaggagtc accttttgtt atgatgtcag caccacctgc 5700

tcagtatgaa cttaagcatg gtacatttac ttgtgctagt gagtacactg gtaattacca 5760

gtgtggtcac tataaacata taacttctaa agaaactttg tattgcatag acggtgcttt 5820

acttacaaag tcctcagaat acaaaggtcc tattacggat gttttctaca aagaaaacag 5880

ttacacaaca accataaaac cagttactta taaattggat ggtgttgttt gtacagaaat 5940

tgaccctaag ttggacaatt attataagaa agacaattct tatttcacag agcaaccaat 6000

tgatcttgta ccaaaccaac catatccaaa cgcaagcttc gataatttta agtttgtatg 6060

tgataatatc aaatttgctg atgatttaaa ccagttaact ggttataaga aacctgcttc 6120

aagagagctt aaagttacat ttttccctga cttaaatggt gatgtggtgg ctattgatta 6180

taaacactac acaccctctt ttaagaaagg agctaaattg ttacataaac ctattgtttg 6240

gcatgttaac aatgcaacta ataaagccac gtataaacca aatacctggt gtatacgttg 6300

tctttggagc acaaaaccag ttgaaacatc aaattcgttt gatgtactga agtcagagga 6360

cgcgcaggga atggataatc ttgcctgcga agatctaaaa ccagtctctg aagaagtagt 6420

ggaaaatcct accatacaga aagacgttct tgagtgtaat gtgaaaacta ccgaagttgt 6480

aggagacatt atacttaaac cagcaaataa tagtttaaaa attacagaag aggttggcca 6540

cacagatcta atggctgctt atgtagacaa ttctagtctt actattaaga aacctaatga 6600

attatctaga gtattaggtt tgaaaaccct tgctactcat ggtttagctg ctgttaatag 6660

tgtcccttgg gatactatag ctaattatgc taagcctttt cttaacaaag ttgttagtac 6720

aactactaac atagttacac ggtgtttaaa ccgtgtttgt actaattata tgccttattt 6780

ctttacttta ttgctacaat tgtgtacttt tactagaagt acaaattcta gaattaaagc 6840

atctatgccg actactatag caaagaatac tgttaagagt gtcggtaaat tttgtctaga 6900

ggcttcattt aattatttga agtcacctaa tttttctaaa ctgataaata ttataatttg 6960

gtttttacta ttaagtgttt gcctaggttc tttaatctac tcaaccgctg ctttaggtgt 7020

tttaatgtct aatttaggca tgccttctta ctgtactggt tacagagaag gctatttgaa 7080

ctctactaat gtcactattg caacctactg tactggttct ataccttgta gtgtttgtct 7140

tagtggttta gattctttag acacctatcc ttctttagaa actatacaaa ttaccatttc 7200

atcttttaaa tgggatttaa ctgcttttgg cttagttgca gagtggtttt tggcatatat 7260

tcttttcact aggtttttct atgtacttgg attggctgca atcatgcaat tgtttttcag 7320

ctattttgca gtacatttta ttagtaattc ttggcttatg tggttaataa ttaatcttgt 7380

acaaatggcc ccgatttcag ctatggttag aatgtacatc ttctttgcat cattttatta 7440

tgtatggaaa agttatgtgc atgttgtaga cggttgtaat tcatcaactt gtatgatgtg 7500

ttacaaacgt aatagagcaa caagagtcga atgtacaact attgttaatg gtgttagaag 7560

gtccttttat gtctatgcta atggaggtaa aggcttttgc aaactacaca attggaattg 7620

tgttaattgt gatacattct gtgctggtag tacatttatt agtgatgaag ttgcgagaga 7680

cttgtcacta cagtttaaaa gaccaataaa tcctactgac cagtcttctt acatcgttga 7740

tagtgttaca gtgaagaatg gttccatcca tctttacttt gataaagctg gtcaaaagac 7800

ttatgaaaga cattctctct ctcattttgt taacttagac aacctgagag ctaataacac 7860

taaaggttca ttgcctatta atgttatagt ttttgatggt aaatcaaaat gtgaagaatc 7920

atctgcaaaa tcagcgtctg tttactacag tcagcttatg tgtcaaccta tactgttact 7980

agatcaggca ttagtgtctg atgttggtga tagtgcggaa gttgcagtta aaatgtttga 8040

tgcttacgtt aatacgtttt catcaacttt taacgtacca atggaaaaac tcaaaacact 8100

agttgcaact gcagaagctg aacttgcaaa gaatgtgtcc ttagacaatg tcttatctac 8160

ttttatttca gcagctcggc aagggtttgt tgattcagat gtagaaacta aagatgttgt 8220

tgaatgtctt aaattgtcac atcaatctga catagaagtt actggcgata gttgtaataa 8280

ctatatgctc acctataaca aagttgaaaa catgacaccc cgtgaccttg gtgcttgtat 8340

tgactgtagt gcgcgtcata ttaatgcgca ggtagcaaaa agtcacaaca ttgctttgat 8400

atggaacgtt aaagatttca tgtcattgtc tgaacaacta cgaaaacaaa tacgtagtgc 8460

tgctaaaaag aataacttac cttttaagtt gacatgtgca actactagac aagttgttaa 8520

tgttgtaaca acaaagatag cacttaaggg tggtaaaatt gttaataatt ggttgaagca 8580

gttaattaaa gttacacttg tgttcctttt tgttgctgct attttctatt taataacacc 8640

tgttcatgtc atgtctaaac atactgactt ttcaagtgaa atcataggat acaaggctat 8700

tgatggtggt gtcactcgtg acatagcatc tacagatact tgttttgcta acaaacatgc 8760

tgattttgac acatggttta gccagcgtgg tggtagttat actaatgaca aagcttgccc 8820

attgattgct gcagtcataa caagagaagt gggttttgtc gtgcctggtt tgcctggcac 8880

gatattacgc acaactaatg gtgacttttt gcatttctta cctagagttt ttagtgcagt 8940

tggtaacatc tgttacacac catcaaaact tatagagtac actgactttg caacatcagc 9000

ttgtgttttg gctgctgaat gtacaatttt taaagatgct tctggtaagc cagtaccata 9060

ttgttatgat accaatgtac tagaaggttc tgttgcttat gaaagtttac gccctgacac 9120

acgttatgtg ctcatggatg gctctattat tcaatttcct aacacctacc ttgaaggttc 9180

tgttagagtg gtaacaactt ttgattctga gtactgtagg cacggcactt gtgaaagatc 9240

agaagctggt gtttgtgtat ctactagtgg tagatgggta cttaacaatg attattacag 9300

atctttacca ggagttttct gtggtgtaga tgctgtaaat ttacttacta atatgtttac 9360

accactaatt caacctattg gtgctttgga catatcagca tctatagtag ctggtggtat 9420

tgtagctatc gtagtaacat gccttgccta ctattttatg aggtttagaa gagcttttgg 9480

tgaatacagt catgtagttg cctttaatac tttactattc cttatgtcat tcactgtact 9540

ctgtttaaca ccagtttact cattcttacc tggtgtttat tctgttattt acttgtactt 9600

gacattttat cttactaatg atgtttcttt tttagcacat attcagtgga tggttatgtt 9660

cacaccttta gtacctttct ggataacaat tgcttatatc atttgtattt ccacaaagca 9720

tttctattgg ttctttagta attacctaaa gagacgtgta gtctttaatg gtgtttcctt 9780

tagtactttt gaagaagctg cgctgtgcac ctttttgtta aataaagaaa tgtatctaaa 9840

gttgcgtagt gatgtgctat tacctcttac gcaatataat agatacttag ctctttataa 9900

taagtacaag tattttagtg gagcaatgga tacaactagc tacagagaag ctgcttgttg 9960

tcatctcgca aaggctctca atgacttcag taactcaggt tctgatgttc tttaccaacc 10020

accacaaacc tctatcacct cagctgtttt gcagagtggt tttagaaaaa tggcattccc 10080

atctggtaaa gttgagggtt gtatggtaca agtaacttgt ggtacaacta cacttaacgg 10140

tctttggctt gatgacgtag tttactgtcc aagacatgtg atctgcacct ctgaagacat 10200

gcttaaccct aattatgaag atttactcat tcgtaagtct aatcataatt tcttggtaca 10260

ggctggtaat gttcaactca gggttattgg acattctatg caaaattgtg tacttaagct 10320

taaggttgat acagccaatc ctaagacacc taagtataag tttgttcgca ttcaaccagg 10380

acagactttt tcagtgttag cttgttacaa tggttcacca tctggtgttt accaatgtgc 10440

tatgaggccc aatttcacta ttaagggttc attccttaat ggttcatgtg gtagtgttgg 10500

ttttaacata gattatgact gtgtctcttt ttgttacatg caccatatgg aattaccaac 10560

tggagttcat gctggcacag acttagaagg taacttttat ggaccttttg ttgacaggca 10620

aacagcacaa gcagctggta cggacacaac tattacagtt aatgttttag cttggttgta 10680

cgctgctgtt ataaatggag acaggtggtt tctcaatcga tttaccacaa ctcttaatga 10740

ctttaacctt gtggctatga agtacaatta tgaacctcta acacaagacc atgttgacat 10800

actaggacct ctttctgctc aaactggaat tgccgtttta gatatgtgtg cttcattaaa 10860

agaattactg caaaatggta tgaatggacg taccatattg ggtagtgctt tattagaaga 10920

tgaatttaca ccttttgatg ttgttagaca atgctcaggt gttactttcc aaagtgcagt 10980

gaaaagaaca atcaagggta cacaccactg gttgttactc acaattttga cttcactttt 11040

agttttagtc cagagtactc aatggtcttt gttctttttt ttgtatgaaa atgccttttt 11100

accttttgct atgggtatta ttgctatgtc tgcttttgca atgatgtttg tcaaacataa 11160

gcatgcattt ctctgtttgt ttttgttacc ttctcttgcc actgtagctt attttaatat 11220

ggtctatatg cctgctagtt gggtgatgcg tattatgaca tggttggata tggttgatac 11280

tagtttgtct ggttttaagc taaaagactg tgttatgtat gcatcagctg tagtgttact 11340

aatccttatg acagcaagaa ctgtgtatga tgatggtgct aggagagtgt ggacacttat 11400

gaatgtcttg acactcgttt ataaagttta ttatggtaat gctttagatc aagccatttc 11460

catgtgggct cttataatct ctgttacttc taactactca ggtgtagtta caactgtcat 11520

gtttttggcc agaggtattg tttttatgtg tgttgagtat tgccctattt tcttcataac 11580

tggtaataca cttcagtgta taatgctagt ttattgtttc ttaggctatt tttgtacttg 11640

ttactttggc ctcttttgtt tactcaaccg ctactttaga ctgactcttg gtgtttatga 11700

ttacttagtt tctacacagg agtttagata tatgaattca cagggactac tcccacccaa 11760

gaatagcata gatgccttca aactcaacat taaattgttg ggtgttggtg gcaaaccttg 11820

tatcaaagta gccactgtac agtctaaaat gtcagatgta aagtgcacat cagtagtctt 11880

actctcagtt ttgcaacaac tcagagtaga atcatcatct aaattgtggg ctcaatgtgt 11940

ccagttacac aatgacattc tcttagctaa agatactact gaagcctttg aaaaaatggt 12000

ttcactactt tctgttttgc tttccatgca gggtgctgta gacataaaca agctttgtga 12060

agaaatgctg gacaacaggg caaccttaca agctatagcc tcagagttta gttcccttcc 12120

atcatatgca gcttttgcta ctgctcaaga agcttatgag caggctgttg ctaatggtga 12180

ttctgaagtt gttcttaaaa agttgaagaa gtctttgaat gtggctaaat ctgaatttga 12240

ccgtgatgca gccatgcaac gtaagttgga aaagatggct gatcaagcta tgacccaaat 12300

gtataaacag gctagatctg aggacaagag ggcaaaagtt actagtgcta tgcagacaat 12360

gcttttcact atgcttagaa agttggataa tgatgcactc aacaacatta tcaacaatgc 12420

aagagatggt tgtgttccct tgaacataat acctcttaca acagcagcca aactaatggt 12480

tgtcatacca gactataaca catataaaaa tacgtgtgat ggtacaacat ttacttatgc 12540

atcagcattg tgggaaatcc aacaggttgt agatgcagat agtaaaattg ttcaacttag 12600

tgaaattagt atggacaatt cacctaattt agcatggcct cttattgtaa cagctttaag 12660

ggccaattct gctgtcaaat tacagaataa tgagcttagt cctgttgcac tacgacagat 12720

gtcttgtgct gccggtacta cacaaactgc ttgcactgat gacaatgcgt tagcttacta 12780

caacacaaca aagggaggta ggtttgtact tgcactgtta tccgatttac aggatttgaa 12840

atgggctaga ttccctaaga gtgatggaac tggtactatc tatacagaac tggaaccacc 12900

ttgtaggttt gttacagaca cacctaaagg tcctaaagtg aagtatttat actttattaa 12960

aggattaaac aacctaaata gaggtatggt acttggtagt ttagctgcca cagtacgtct 13020

acaagctggt aatgcaacag aagtgcctgc caattcaact gtattatctt tctgtgcttt 13080

tgctgtagat gctgctaaag cttacaaaga ttatctagct agtgggggac aaccaatcac 13140

taattgtgtt aagatgttgt gtacacacac tggtactggt caggcaataa cagttacacc 13200

ggaagccaat atggatcaag aatcctttgg tggtgcatcg tgttgtctgt actgccgttg 13260

ccacatagat catccaaatc ctaaaggatt ttgtgactta aaaggtaagt atgtacaaat 13320

acctacaact tgtgctaatg accctgtggg ttttacactt aaaaacacag tctgtaccgt 13380

ctgcggtatg tggaaaggtt atggctgtag ttgtgatcaa ctccgcgaac ccatgcttca 13440

gtcagctgat gcacaatcgt ttttaaacgg gtttgcggtg taagtgcagc ccgtcttaca 13500

ccgtgcggca caggcactag tactgatgtc gtatacaggg cttttgacat ctacaatgat 13560

aaagtagctg gttttgctaa attcctaaaa actaattgtt gtcgcttcca agaaaaggac 13620

gaagatgaca atttaattga ttcttacttt gtagttaaga gacacacttt ctctaactac 13680

caacatgaag aaacaattta taatttactt aaggattgtc cagctgttgc taaacatgac 13740

ttctttaagt ttagaataga cggtgacatg gtaccacata tatcacgtca acgtcttact 13800

aaatacacaa tggcagacct cgtctatgct ttaaggcatt ttgatgaagg taattgtgac 13860

acattaaaag aaatacttgt cacatacaat tgttgtgatg atgattattt caataaaaag 13920

gactggtatg attttgtaga aaacccagat atattacgcg tatacgccaa cttaggtgaa 13980

cgtgtacgcc aagctttgtt aaaaacagta caattctgtg atgccatgcg aaatgctggt 14040

attgttggtg tactgacatt agataatcaa gatctcaatg gtaactggta tgatttcggt 14100

gatttcatac aaaccacgcc aggtagtgga gttcctgttg tagattctta ttattcattg 14160

ttaatgccta tattaacctt gaccagggct ttaactgcag agtcacatgt tgacactgac 14220

ttaacaaagc cttacattaa gtgggatttg ttaaaatatg acttcacgga agagaggtta 14280

aaactctttg accgttattt taaatattgg gatcagacat accacccaaa ttgtgttaac 14340

tgtttggatg acagatgcat tctgcattgt gcaaacttta atgttttatt ctctacagtg 14400

ttcccactta caagttttgg accactagtg agaaaaatat ttgttgatgg tgttccattt 14460

gtagtttcaa ctggatacca cttcagagag ctaggtgttg tacataatca ggatgtaaac 14520

ttacatagct ctagacttag ttttaaggaa ttacttgtgt atgctgctga ccctgctatg 14580

cacgctgctt ctggtaatct attactagat aaacgcacta cgtgcttttc agtagctgca 14640

cttactaaca atgttgcttt tcaaactgtc aaacccggta attttaacaa agacttctat 14700

gactttgctg tgtctaaggg tttctttaag gaaggaagtt ctgttgaatt aaaacacttc 14760

ttctttgctc aggatggtaa tgctgctatc agcgattatg actactatcg ttataatcta 14820

ccaacaatgt gtgatatcag acaactacta tttgtagttg aagttgttga taagtacttt 14880

gattgttacg atggtggctg tattaatgct aaccaagtca tcgtcaacaa cctagacaaa 14940

tcagctggtt ttccatttaa taaatggggt aaggctagac tttattatga ttcaatgagt 15000

tatgaggatc aagatgcact tttcgcatat acaaaacgta atgtcatccc tactataact 15060

caaatgaatc ttaagtatgc cattagtgca aagaatagag ctcgcaccgt agctggtgtc 15120

tctatctgta gtactatgac caatagacag tttcatcaaa aattattgaa atcaatagcc 15180

gccactagag gagctactgt agtaattgga acaagcaaat tctatggtgg ttggcacaac 15240

atgttaaaaa ctgtttatag tgatgtagaa aaccctcacc ttatgggttg ggattatcct 15300

aaatgtgata gagccatgcc taacatgctt agaattatgg cctcacttgt tcttgctcgc 15360

aaacatacaa cgtgttgtag cttgtcacac cgtttctata gattagctaa tgagtgtgct 15420

caagtattga gtgaaatggt catgtgtggc ggttcactat atgttaaacc aggtggaacc 15480

tcatcaggag atgccacaac tgcttatgct aatagtgttt ttaacatttg tcaagctgtc 15540

acggccaatg ttaatgcact tttatctact gatggtaaca aaattgccga taagtatgtc 15600

cgcaatttac aacacagact ttatgagtgt ctctatagaa atagagatgt tgacacagac 15660

tttgtgaatg agttttacgc atatttgcgt aaacatttct caatgatgat actctctgac 15720

gatgctgttg tgtgtttcaa tagcacttat gcatctcaag gtctagtggc tagcataaag 15780

aactttaagt cagttcttta ttatcaaaac aatgttttta tgtctgaagc aaaatgttgg 15840

actgagactg accttactaa aggacctcat gaattttgct ctcaacatac aatgctagtt 15900

aaacagggtg atgattatgt gtaccttcct tacccagatc catcaagaat cctaggggcc 15960

ggctgttttg tagatgatat cgtaaaaaca gatggtacac ttatgattga acggttcgtg 16020

tctttagcta tagatgctta cccacttact aaacatccta atcaggagta tgctgatgtc 16080

tttcatttgt acttacaata cataagaaag ctacatgatg agttaacagg acacatgtta 16140

gacatgtatt ctgttatgct tactaatgat aacacttcaa ggtattggga acctgagttt 16200

tatgaggcta tgtacacacc gcatacagtc ttacaggctg ttggggcttg tgttctttgc 16260

aattcacaga cttcattaag atgtggtgct tgcatacgta gaccattctt atgttgtaaa 16320

tgctgttacg accatgtcat atcaacatca cataaattag tcttgtctgt taatccgtat 16380

gtttgcaatg ctccaggttg tgatgtcaca gatgtgactc aactttactt aggaggtatg 16440

agctattatt gtaaatcaca taaaccaccc attagttttc cattgtgtgc taatggacaa 16500

gtttttggtt tatataaaaa tacatgtgtt ggtagcgata atgttactga ctttaatgca 16560

attgcaacat gtgactggac aaatgctggt gattacattt tagctaacac ctgtactgaa 16620

agactcaagc tttttgcagc agaaacgctc aaagctactg aggagacatt taaactgtct 16680

tatggtattg ctactgtacg tgaagtgctg tctgacagag aattacatct ttcatgggaa 16740

gttggtaaac ctagaccacc acttaaccga aattatgtct ttactggtta tcgtgtaact 16800

aaaaacagta aagtacaaat aggagagtac acctttgaaa aaggtgacta tggtgatgct 16860

gttgtttacc gaggtacaac aacttacaaa ttaaatgttg gtgattattt tgtgctgaca 16920

tcacatacag taatgccatt aagtgcacct acactagtgc cacaagagca ctatgttaga 16980

attactggct tatacccaac actcaatatc tcagatgagt tttctagcaa tgttgcaaat 17040

tatcaaaagg ttggtatgca aaagtattct acactccagg gaccacctgg tactggtaag 17100

agtcattttg ctattggcct agctctctac tacccttctg ctcgcatagt gtatacagct 17160

tgctctcatg ccgctgttga tgcactatgt gagaaggcat taaaatattt gcctatagat 17220

aaatgtagta gaattatacc tgcacgtgct cgtgtagagt gttttgataa attcaaagtg 17280

aattcaacat tagaacagta tgtcttttgt actgtaaatg cattgcctga gacgacagca 17340

gatatagttg tctttgatga aatttcaatg gccacaaatt atgatttgag tgttgtcaat 17400

gccagattac gtgctaagca ctatgtgtac attggcgacc ctgctcaatt acctgcacca 17460

cgcacattgc taactaaggg cacactagaa ccagaatatt tcaattcagt gtgtagactt 17520

atgaaaacta taggtccaga catgttcctc ggaacttgtc ggcgttgtcc tgctgaaatt 17580

gttgacactg tgagtgcttt ggtttatgat aataagctta aagcacataa agacaaatca 17640

gctcaatgct ttaaaatgtt ttataagggt gttatcacgc atgatgtttc atctgcaatt 17700

aacaggccac aaataggcgt ggtaagagaa ttccttacac gtaaccctgc ttggagaaaa 17760

gctgtcttta tttcacctta taattcacag aatgctgtag cctcaaagat tttgggacta 17820

ccaactcaaa ctgttgattc atcacagggc tcagaatatg actatgtcat attcactcaa 17880

accactgaaa cagctcactc ttgtaatgta aacagattta atgttgctat taccagagca 17940

aaagtaggca tactttgcat aatgtctgat agagaccttt atgacaagtt gcaatttaca 18000

agtcttgaaa ttccacgtag gaatgtggca actttacaag ctgaaaatgt aacaggactc 18060

tttaaagatt gtagtaaggt aatcactggg ttacatccta cacaggcacc tacacacctc 18120

agtgttgaca ctaaattcaa aactgaaggt ttatgtgttg acatacctgg catacctaag 18180

gacatgacct atagaagact catctctatg atgggtttta aaatgaatta tcaagttaat 18240

ggttacccta acatgtttat cacccgcgaa gaagctataa gacatgtacg tgcatggatt 18300

ggcttcgatg tcgaggggtg tcatgctact agagaagctg ttggtaccaa tttaccttta 18360

cagctaggtt tttctacagg tgttaaccta gttgctgtac ctacaggtta tgttgataca 18420

cctaataata cagatttttc cagagttagt gctaaaccac cgcctggaga tcaatttaaa 18480

cacctcatac cacttatgta caaaggactt ccttggaatg tagtgcgtat aaagattgta 18540

caaatgttaa gtgacacact taaaaatctc tctgacagag tcgtatttgt cttatgggca 18600

catggctttg agttgacatc tatgaagtat tttgtgaaaa taggacctga gcgcacctgt 18660

tgtctatgtg atagacgtgc cacatgcttt tccactgctt cagacactta tgcctgttgg 18720

catcattcta ttggatttga ttacgtctat aatccgttta tgattgatgt tcaacaatgg 18780

ggttttacag gtaacctaca aagcaaccat gatctgtatt gtcaagtcca tggtaatgca 18840

catgtagcta gttgtgatgc aatcatgact aggtgtctag ctgtccacga gtgctttgtt 18900

aagcgtgttg actggactat tgaatatcct ataattggtg atgaactgaa gattaatgcg 18960

gcttgtagaa aggttcaaca catggttgtt aaagctgcat tattagcaga caaattccca 19020

gttcttcacg acattggtaa ccctaaagct attaagtgtg tacctcaagc tgatgtagaa 19080

tggaagttct atgatgcaca gccttgtagt gacaaagctt ataaaataga agaattattc 19140

tattcttatg ccacacattc tgacaaattc acagatggtg tatgcctatt ttggaattgc 19200

aatgtcgata gatatcctgc taattccatt gtttgtagat ttgacactag agtgctatct 19260

aaccttaact tgcctggttg tgatggtggc agtttgtatg taaataaaca tgcattccac 19320

acaccagctt ttgataaaag tgcttttgtt aatttaaaac aattaccatt tttctattac 19380

tctgacagtc catgtgagtc tcatggaaaa caagtagtgt cagatataga ttatgtacca 19440

ctaaagtctg ctacgtgtat aacacgttgc aatttaggtg gtgctgtctg tagacatcat 19500

gctaatgagt acagattgta tctcgatgct tataacatga tgatctcagc tggctttagc 19560

ttgtgggttt acaaacaatt tgatacttat aacctctgga acacttttac aagacttcag 19620

agtttagaaa atgtggcttt taatgttgta aataagggac actttgatgg acaacagggt 19680

gaagtaccag tttctatcat taataacact gtttacacaa aagttgatgg tgttgatgta 19740

gaattgtttg aaaataaaac aacattacct gttaatgtag catttgagct ttgggctaag 19800

cgcaacatta aaccagtacc agaggtgaaa atactcaata atttgggtgt ggacattgct 19860

gctaatactg tgatctggga ctacaaaaga gatgctccag cacatatatc tactattggt 19920

gtttgttcta tgactgacat agccaagaaa ccaactgaaa cgatttgtgc accactcact 19980

gtcttttttg atggtagagt tgatggtcaa gtagacttat ttagaaatgc ccgtaatggt 20040

gttcttatta cagaaggtag tgttaaaggt ttacaaccat ctgtaggtcc caaacaagct 20100

agtcttaatg gagtcacatt aattggagaa gccgtaaaaa cacagttcaa ttattataag 20160

aaagttgatg gtgttgtcca acaattacct gaaacttact ttactcagag tagaaattta 20220

caagaattta aacccaggag tcaaatggaa attgatttct tagaattagc tatggatgaa 20280

ttcattgaac ggtataaatt agaaggctat gccttcgaac atatcgttta tggagatttt 20340

agtcatagtc agttaggtgg tttacatcta ctgattggac tagctaaacg ttttaaggaa 20400

tcaccttttg aattagaaga ttttattcct atggacagta cagttaaaaa ctatttcata 20460

acagatgcgc aaacaggttc atctaagtgt gtgtgttctg ttattgattt attacttgat 20520

gattttgttg aaataataaa atcccaagat ttatctgtag tttctaaggt tgtcaaagtg 20580

actattgact atacagaaat ttcatttatg ctttggtgta aagatggcca tgtagaaaca 20640

ttttacccaa aattacaatc tagtcaagcg tggcaaccgg gtgttgctat gcctaatctt 20700

tacaaaatgc aaagaatgct attagaaaag tgtgaccttc aaaattatgg tgatagtgca 20760

acattaccta aaggcataat gatgaatgtc gcaaaatata ctcaactgtg tcaatattta 20820

aacacattaa cattagctgt accctataat atgagagtta tacattttgg tgctggttct 20880

gataaaggag ttgcaccagg tacagctgtt ttaagacagt ggttgcctac gggtacgctg 20940

cttgtcgatt cagatcttaa tgactttgtc tctgatgcag attcaacttt gattggtgat 21000

tgtgcaactg tacatacagc taataaatgg gatctcatta ttagtgatat gtacgaccct 21060

aagactaaaa atgttacaaa agaaaatgac tctaaagagg gttttttcac ttacatttgt 21120

gggtttatac aacaaaagct agctcttgga ggttccgtgg ctataaagat aacagaacat 21180

tcttggaatg ctgatcttta taagctcatg ggacacttcg catggtggac agcctttgtt 21240

actaatgtga atgcgtcatc atctgaagca tttttaattg gatgtaatta tcttggcaaa 21300

ccacgcgaac aaatagatgg ttatgtcatg catgcaaatt acatattttg gaggaataca 21360

aatccaattc agttgtcttc ctattcttta tttgacatga gtaaatttcc ccttaaatta 21420

aggggtactg ctgttatgtc tttaaaagaa ggtcaaatca atgatatgat tttatctctt 21480

cttagtaaag gtagacttat aattagagaa aacaacagag ttgttatttc tagtgatgtt 21540

cttgttaaca actaaacgaa caatgtttgt ttttcttgtt ttattgccac tagtctctag 21600

tcagtgtgtt aatcttacaa ccagaactca attaccccct gcatacacta attctttcac 21660

acgtggtgtt tattaccctg acaaagtttt cagatcctca gttttacatt caactcagga 21720

cttgttctta cctttctttt ccaatgttac ttggttccat gctatacatg tctctgggac 21780

caatggtact aagaggtttg ataaccctgt cctaccattt aatgatggtg tttattttgc 21840

ttccactgag aagtctaaca taataagagg ctggattttt ggtactactt tagattcgaa 21900

gacccagtcc ctacttattg ttaataacgc tactaatgtt gttattaaag tctgtgaatt 21960

tcaattttgt aatgatccat ttttgggtgt ttattaccac aaaaacaaca aaagttggat 22020

ggaaagtgag ttcagagttt attctagtgc gaataattgc acttttgaat atgtctctca 22080

gccttttctt atggaccttg aaggaaaaca gggtaatttc aaaaatctta gggaatttgt 22140

gtttaagaat attgatggtt attttaaaat atattctaag cacacgccta ttaatttagt 22200

gcgtgatctc cctcagggtt tttcggcttt agaaccattg gtagatttgc caataggtat 22260

taacatcact aggtttcaaa ctttacttgc tttacataga agttatttga ctcctggtga 22320

ttcttcttca ggttggacag ctggtgctgc agcttattat gtgggttatc ttcaacctag 22380

gacttttcta ttaaaatata atgaaaatgg aaccattaca gatgctgtag actgtgcact 22440

tgaccctctc tcagaaacaa agtgtacgtt gaaatccttc actgtagaaa aaggaatcta 22500

tcaaacttct aactttagag kccaaccaac agaatctatt gttagatttc ctaatattac 22560

aaacttgtgc ccttttggtg aagtttttaa cgccaccaga tttgcatctg tttatgcttg 22620

gaacaggaag agaatcagca actgtgttgc tgattattct gtcctatata attccgcatc 22680

attttccact tttaagtgtt atggagtgtc tcctactaaa ttaaatgatc tctgctttac 22740

taatgtctat gcagattcat ttgtaattag aggtgatgaa gtcagacaaa tcgctccagg 22800

gcaaactgga aagattgctg attataatta taaattacca gatgatttta caggctgcgt 22860

tatagcttgg aattctaaca atcttgattc taaggttggt ggtaattata attacctgta 22920

tagattgttt aggaagtcta atctcaaacc ttttgagaga gatatttcaa ctgaaatcta 22980

tcaggccggt agcacacctt gtaatggtgt tgaaggtttt aattgttact ttcctttaca 23040

atcatatggt ttccaaccca ctaatggtgt tggttaccaa ccatacagag tagtagtact 23100

ttcttttgaa cttctacatg caccagcaac tgtttgtgga cctaaaaagt ctactaattt 23160

ggttaaaaac aaatgtgtca atttcaactt caatggttta acaggcacag gtgttcttac 23220

tgagtctaac aaaaagtttc tgcctttcca acaatttggc agagacattg ctgacactac 23280

tgatgctgtc cgtgatccac agacacttga gattcttgac attacaccat gttcttttgg 23340

tggtgtcagt gttataacac caggaacaaa tacttctaac caggttgctg ttctttatca 23400

gggtgttaac tgcacagaag tccctgttgc tattcatgca gatcaactta ctcctacttg 23460

gcgtgtttat tctacaggtt ctaatgtttt tcaaacacgt gcaggctgtt taataggggc 23520

tgaacatgtc aacaactcat atgagtgtga catacccatt ggtgcaggta tatgcgctag 23580

ttatcagact cagactaatt ctcctcggcg ggcacgtagt gtagctagtc aatccatcat 23640

tgcctacact atgtcacttg gtgcagaaaa ttcagttgct tactctrata actctattgc 23700

catacccaca aattttacta ttagtgttac cacagaaatt ctaccagtgt ctatgaccaa 23760

gacatcagta gattgtacaa tgtacatttg tggtgattca actgaatgca gcaatctttt 23820

gttgcaatat ggcagttttt gtacacaatt aaaccgtgct ttaactggaa tagctgttga 23880

acaagacaaa aacacccaag aagtttttgc acaagtcaaa caaatttaca aaacaccacc 23940

aattaaagat tttggtggtt ttaatttttc acaaatatta ccagatccat caaaaccaag 24000

caagaggtca tttattgaag atctactttt caacaaagtg acacttgcag atgctggctt 24060

catcaaacaa tatggtgatt gccttggtga tattgctgct agagacctca tttgtgcaca 24120

aaagtttaac ggccttactg ttttgccacc tttgctcaca gatgaaatga ttgctcaata 24180

cacttctgca ctgttagcgg gtacaatcac ttctggttgg acctttggtg caggtgctgc 24240

attacaaata ccatttgcta tgcaaatggc ttataggttt aatggtattg gagttacaca 24300

gaatgttctc tatgagaacc aaaaattgat tgccaaccaa tttaatagtg ctattggcaa 24360

aattcaagac tcactttctt ccacagcaag tgcacttgga aaacttcaag atgtggtcaa 24420

ccaaaatgca caagctttaa acacgcttgt taaacaactt agctccaatt ttggtgcaat 24480

ttcaagtgtt ttaaatgata tcctttcacg tcttgacaaa gttgaggctg aagtgcaaat 24540

tgataggttg atcacaggca gacttcaaag tttgcagaca tatgtgactc aacaattaat 24600

tagagctgca gaaatcagag tttctgctaa tcttgctgct actaaaatgt cagagtgtgt 24660

acttggacaa tcaaaaagag ttgatttttg tggaaagggc tatcatctta tgtccttccc 24720

tcagtcagca cctcatggtg tagtcttctt gcatgtgact tatgtccctg cacaagaaaa 24780

gaacttcaca actgctcctg ccatttgtca tgatggaaaa gcacactttc ctcgtgaagg 24840

tgtctttgtt tcaaatggca cacactggtt tgtaacacaa aggaattttt atgaaccaca 24900

aatcattact acagacaaca catttgtgtc tggtaactgt gatgttgtaa taggaattgt 24960

caacaacaca gtttatgatc ctttgcaacc tgaattagac tcattcaagg aggagttaga 25020

taaatatttt aagaatcata catcaccaga tgttgattta ggtgacatct ctggcattaa 25080

tgcttcagtt gtaaacattc aaaaagaaat tgaccgcctc aatgaggttg ccaagaattt 25140

aaatgaatct ctcatcgatc tccaagaact tggaaagtat gagcagtata taaaatggcc 25200

atggtacatt tggctaggtt ttatagctgg cttgattgcc atagtaatgg tgacaattat 25260

gctttgctgt atgaccagtt gctgtagttg tctcaagggc tgttgttctt gtggatcctg 25320

ctgcaaattt gatgaagacg actctgagcc agtgctcaaa ggagtcaaat tacattacac 25380

ataaacgaac ttatggattt gtttatgaga atcttcacaa ttggaactgt aactttgaag 25440

caaggtgaaa tcaaggatgc tactccttca gattttgttc gcgctactgc aacgataccg 25500

atacaagcct cactcccttt cggatggctt attgttggcg ttgcacttct tgctgttttt 25560

cagagcgctt ccaaaatcat aaccctcaaa aagagatggc aactagcact ctccaagggt 25620

gttcactttg tttgcaactt gctgttgttg tttgtaacag tttactcaca ccttttgctc 25680

gttgctgctg gccttgaagc cccttttctc tatctttatg ctttagtcta cttcttgcag 25740

agtataaact ttgtaagaat aataatgagg ctttggcttt gctggaaatg ccgttccaaa 25800

aacccattac tttatgatgc caactatttt ctttgctggc atactaattg ttacgactat 25860

tgtatacctt acaatagtgt aacttcttca attgtcatta cttcaggtga tggcacaaca 25920

agtcctattt ctgaacatga ctaccagatt ggtggttata ctgaaaaatg ggaatctgga 25980

gtaaaagact gtgttgtatt acacagttac ttcacttcag actattacca gctgtactca 26040

actcaattga gtacagacac tggtgttgaa catgttacct tcttcatcta caataaaatt 26100

gttgatgagc ctgaagaaca tgtccaaatt cacacaatcg acggttcatc cggagttgtt 26160

aatccagtaa tggaaccaat ttatgatgaa ccgacgacga ctactagcgt gcctttgtaa 26220

gcacaagctg atgagtacga acttatgtac tcattcgttt cggaagagmc aggtacgtta 26280

atagttaata gcgtacttct ttttcttgct ttcgtggtat tcttgctagt tacactagcc 26340

atccttactg cgcttcgatt gtgtgcgtac tgctgcaata ttgttaacgt gagtcttgta 26400

aaaccttctt tttacgttta ctctcgtgtt aaaaatctga attcttctag agttcctgat 26460

cttctggtct aaacgaacta aatattatat tagtttttct gtttggaact ttaattttag 26520

ccatggcaga ttccaacggt actattaccg ttgaagagct taaaaagctc cttgaacaat 26580

ggaacctagt aataggtttc ctattcctta catggatttg tcttctacaa tttgcctatg 26640

ccaacaggaa taggtttttg tatataatta agttaatttt cctctggctg ttatggccag 26700

taactttagc ttgttttgtg cttgctgctg tttacagaat aaattggatc accggtggaa 26760

ttgctatcgc aatggcttgt cttgtaggct tgatgtggct cagctacttc attgcttctt 26820

tcagactgtt tgcgcgtacg cgttccatgt ggtcattcaa tccagaaact aacattcttc 26880

tcaacgtgcc actccatggc actattctga ccagaccgct tctagaaagt gaactcgtaa 26940

tcggagctgt gatccttcgt ggacatcttc gtattgctgg acaccatcta ggacgctgtg 27000

acatcaagga cctgcctaaa gaaatcactg ttgctacatc acgaatgctt tcttattaca 27060

aattgggagc ttcgcagcgt gtagcaggtg actcaggttt tgctgcatac agtcgctaca 27120

ggattggcaa ctataaatta aacacagacc attccagtag cagtgacaat attgctttgc 27180

ttgtacagta agtgacaaca gatgtttcat ctcgttgact ttcaggttac tatagcagag 27240

atattactaa ttattatgag gacttttaaa gtttccattt ggaatcttga ttacatcata 27300

aacctcataa ttaaaaattt atctaagtca ctaactgaga ataaatattc tcaattagat 27360

gaagagcaac caatggagat tgattaaacg aacatgaaaa ttattctttt cttggcactg 27420

ataacactcg ctacttgtga gctttatcac taccaagagt gtgttagagg tacaacagta 27480

cttttaaaag aaccttgctc ttctggaaca tacgagggca attcaccatt tcatcctcta 27540

gctgataaca aatttgcact gacttgcttt agcactcaat ttgcttttgc ttgtcctgac 27600

ggcgtaaaac acgtctatca gttacgtgcc agatcagttt cacctaaact gttcatcaga 27660

caagaggaag ttcaagaact ttactctcca atttttctta ttgttgcggc aatagtgttt 27720

ataacacttt gcttcacact caaaagaaag acagaatgat tgaactttca ttaattgact 27780

tctatttgtg ctttttagcc tttctgctat tccttgtttt aattatgctt attatctttt 27840

ggttctcact tgaactgcaa gatcataatg aaacttgtca cgcctaaacg aacatgaaat 27900

ttcttgtttt cttaggaatc atcacaactg tagctgcatt tcaccaagaa tgtagtttac 27960

agtcatgtac tcaacatcaa ccatatgtag ttgatgaccc gtgtcctatt cacttctatt 28020

ctaaatggta tattagagta ggagctagaa aatcagcacc tttaattgaa ttgtgcgtgg 28080

atgaggctgg ttctaaatca cccattcagt acatcgatat cggtaattat acagtttcct 28140

gtttaccttt tacaattaat tgccaggaac ctaaattggg tagtcttgta gtgcgttgtt 28200

cgttctatga agacttttta gagtatcatg acgttcgtgt tgttttagat ttcatctaaa 28260

cgaacaaact aaaatgtctg ataatggacc ccaaaatcag cgaaatgcac cccgcattac 28320

gtttggtgga ccctcagatt caactggcag taaccagaat ggagaacgca gtggggcgcg 28380

atcaaaacaa cgtcggcccc aaggtttacc caataatact gcgtcttggt tcaccgctct 28440

cactcaacat ggcaaggaag accttaaatt ccctcgagga caaggcgttc caattaacac 28500

caatagcagt ccagatgacc aaattggcta ctaccgaaga gctaccagac gaattcgtgg 28560

tggtgacggt aaaatgaaag atctcagtcc aagatggtat ttctactacc taggaactgg 28620

gccagaagct ggacttccct atggtgctaa caaagacggc atcatatggg ttgcaactga 28680

gggagccttg aatacaccaa aagatcacat tggcacccgc aatcctgcta acaatgctgc 28740

aatcgtgcta caacttcctc aaggaacaac attgccaaaa ggcttctacg cagaagggag 28800

cagaggcggc agtcaagcct cttctcgttc ctcatcacgt agtcgcaaca gttcaagaaa 28860

ttcaactcca ggcagcagta aacgaacttc tcctgctaga atggctggca atggcggtga 28920

tgctgctctt gctttgctgc tgcttgacag attgaaccag cttgagagca aaatgtctgg 28980

taaaggccaa caacaacaag gccaaactgt cactaagaaa tctgctgctg aggcttctaa 29040

gaagcctcgg caaaaacgta ctgccactaa agcatacaat gtaacacaag ctttcggcag 29100

acgtggtcca gaacaaaccc aaggaaattt tggggaccag gaactaatca gacaaggaac 29160

tgattacaaa cattggccgc aaattgcaca atttgccccc agcgcttcag cgttcttcgg 29220

aatgtcgcgc attggcatgg aagtcacacc ttcgggaacg tggttgacct acacaggtgc 29280

catcaaattg gatgacaaag atccaaattt caaagatcaa gtcattttgc tgaataagca 29340

tattgacgca tacaaaacat tcccaccaac agagcctaaa aaggacaaaa agaagaaggc 29400

tgatgaaact caagccttac cgcagagaca gaagaaacag caaactgtga ctcttcttcc 29460

tgctgcagat ttggatgatt tctccaaaca attgcaacaa tccatgagca gtgctgactc 29520

aactcaggcc taaactcatg cagaccacac aaggcagatg ggctatataa acgttttcgc 29580

ttttccgttt acgatatata gtctactctt gtgcagaatg aattctcgta actacatagc 29640

acaagtagat gtagttaact ttaatctcac atagcaatct ttaatcagtg tgtaacatta 29700

gggaggactt gaaagagcca ccacattttc accgaggcca cgcggagtac gatcgagtgt 29760

acagtgaaca atgctaggga gagctgccta tatggaagag ccctaatgtg taaaattaat 29820

tttagtagtg ctatccccat gtgattttaa tagcttctta ggagnatgac annnnnnnnn 29880

nnnnn 29885

<210> 16

<211> 4405

<212> PRT

<213> SARS-CoV2

<400> 16

Met Glu Ser Leu Val Pro Gly Phe Asn Glu Lys Thr His Val Gln Leu

1 5 10 15

Ser Leu Pro Val Leu Gln Val Arg Asp Val Leu Val Arg Gly Phe Gly

20 25 30

Asp Ser Val Glu Glu Val Leu Ser Glu Ala Arg Gln His Leu Lys Asp

35 40 45

Gly Thr Cys Gly Leu Val Glu Val Glu Lys Gly Val Leu Pro Gln Leu

50 55 60

Glu Gln Pro Tyr Val Phe Ile Lys Arg Ser Asp Ala Arg Thr Ala Pro

65 70 75 80

His Gly His Val Met Val Glu Leu Val Ala Glu Leu Glu Gly Ile Gln

85 90 95

Tyr Gly Arg Ser Gly Glu Thr Leu Gly Val Leu Val Pro His Val Gly

100 105 110

Glu Ile Pro Val Ala Tyr Arg Lys Val Leu Leu Arg Lys Asn Gly Asn

115 120 125

Lys Gly Ala Gly Gly His Ser Tyr Gly Ala Asp Leu Lys Ser Phe Asp

130 135 140

Leu Gly Asp Glu Leu Gly Thr Asp Pro Tyr Glu Asp Phe Gln Glu Asn

145 150 155 160

Trp Asn Thr Lys His Ser Ser Gly Val Thr Arg Glu Leu Met Arg Glu

165 170 175

Leu Asn Gly Gly Ala Tyr Thr Arg Tyr Val Asp Asn Asn Phe Cys Gly

180 185 190

Pro Asp Gly Tyr Pro Leu Glu Cys Ile Lys Asp Leu Leu Ala Arg Ala

195 200 205

Gly Lys Ala Ser Cys Thr Leu Ser Glu Gln Leu Asp Phe Ile Asp Thr

210 215 220

Lys Arg Gly Val Tyr Cys Cys Arg Glu His Glu His Glu Ile Ala Trp

225 230 235 240

Tyr Thr Glu Arg Ser Glu Lys Ser Tyr Glu Leu Gln Thr Pro Phe Glu

245 250 255

Ile Lys Leu Ala Lys Lys Phe Asp Thr Phe Asn Gly Glu Cys Pro Asn

260 265 270

Phe Val Phe Pro Leu Asn Ser Ile Ile Lys Thr Ile Gln Pro Arg Val

275 280 285

Glu Lys Lys Lys Leu Asp Gly Phe Met Gly Arg Ile Arg Ser Val Tyr

290 295 300

Pro Val Ala Ser Pro Asn Glu Cys Asn Gln Met Cys Leu Ser Thr Leu

305 310 315 320

Met Lys Cys Asp His Cys Gly Glu Thr Ser Trp Gln Thr Gly Asp Phe

325 330 335

Val Lys Ala Thr Cys Glu Phe Cys Gly Thr Glu Asn Leu Thr Lys Glu

340 345 350

Gly Ala Thr Thr Cys Gly Tyr Leu Pro Gln Asn Ala Val Val Lys Ile

355 360 365

Tyr Cys Pro Ala Cys His Asn Ser Glu Val Gly Pro Glu His Ser Leu

370 375 380

Ala Glu Tyr His Asn Glu Ser Gly Leu Lys Thr Ile Leu Arg Lys Gly

385 390 395 400

Gly Arg Thr Ile Ala Phe Gly Gly Cys Val Phe Ser Tyr Val Gly Cys

405 410 415

His Asn Lys Cys Ala Tyr Trp Val Pro Arg Ala Ser Ala Asn Ile Gly

420 425 430

Cys Asn His Thr Gly Val Val Gly Glu Gly Ser Glu Gly Leu Asn Asp

435 440 445

Asn Leu Leu Glu Ile Leu Gln Lys Glu Lys Val Asn Ile Asn Ile Val

450 455 460

Gly Asp Phe Lys Leu Asn Glu Glu Ile Ala Ile Ile Leu Ala Ser Phe

465 470 475 480

Ser Ala Ser Thr Ser Ala Phe Val Glu Thr Val Lys Gly Leu Asp Tyr

485 490 495

Lys Ala Phe Lys Gln Ile Val Glu Ser Cys Gly Asn Phe Lys Val Thr

500 505 510

Lys Gly Lys Ala Lys Lys Gly Ala Trp Asn Ile Gly Glu Gln Lys Ser

515 520 525

Ile Leu Ser Pro Leu Tyr Ala Phe Ala Ser Glu Ala Ala Arg Val Val

530 535 540

Arg Ser Ile Phe Ser Arg Thr Leu Glu Thr Ala Gln Asn Ser Val Arg

545 550 555 560

Val Leu Gln Lys Ala Ala Ile Thr Ile Leu Asp Gly Ile Ser Gln Tyr

565 570 575

Ser Leu Arg Leu Ile Asp Ala Met Met Phe Thr Ser Asp Leu Ala Thr

580 585 590

Asn Asn Leu Val Val Met Ala Tyr Ile Thr Gly Gly Val Val Gln Leu

595 600 605

Thr Ser Gln Trp Leu Thr Asn Ile Phe Gly Thr Val Tyr Glu Lys Leu

610 615 620

Lys Pro Val Leu Asp Trp Leu Glu Glu Lys Phe Lys Glu Gly Val Glu

625 630 635 640

Phe Leu Arg Asp Gly Trp Glu Ile Val Lys Phe Ile Ser Thr Cys Ala

645 650 655

Cys Glu Ile Val Gly Gly Gln Ile Val Thr Cys Ala Lys Glu Ile Lys

660 665 670

Glu Ser Val Gln Thr Phe Phe Lys Leu Val Asn Lys Phe Leu Ala Leu

675 680 685

Cys Ala Asp Ser Ile Ile Ile Gly Gly Ala Lys Leu Lys Ala Leu Asn

690 695 700

Leu Gly Glu Thr Phe Val Thr His Ser Lys Gly Leu Tyr Arg Lys Cys

705 710 715 720

Val Lys Ser Arg Glu Glu Thr Gly Leu Leu Met Pro Leu Lys Ala Pro

725 730 735

Lys Glu Ile Ile Phe Leu Glu Gly Glu Thr Leu Pro Thr Glu Val Leu

740 745 750

Thr Glu Glu Val Val Leu Lys Thr Gly Asp Leu Gln Pro Leu Glu Gln

755 760 765

Pro Thr Ser Glu Ala Val Glu Ala Pro Leu Val Gly Thr Pro Val Cys

770 775 780

Ile Asn Gly Leu Met Leu Leu Glu Ile Lys Asp Thr Glu Lys Tyr Cys

785 790 795 800

Ala Leu Ala Pro Asn Met Met Val Thr Asn Asn Thr Phe Thr Leu Lys

805 810 815

Gly Gly Ala Pro Thr Lys Val Thr Phe Gly Asp Asp Thr Val Ile Glu

820 825 830

Val Gln Gly Tyr Lys Ser Val Asn Ile Thr Phe Glu Leu Asp Glu Arg

835 840 845

Ile Asp Lys Val Leu Asn Glu Lys Cys Ser Ala Tyr Thr Val Glu Leu

850 855 860

Gly Thr Glu Val Asn Glu Phe Ala Cys Val Val Ala Asp Ala Val Ile

865 870 875 880

Lys Thr Leu Gln Pro Val Ser Glu Leu Leu Thr Pro Leu Gly Ile Asp

885 890 895

Leu Asp Glu Trp Ser Met Ala Thr Tyr Tyr Leu Phe Asp Glu Ser Gly

900 905 910

Glu Phe Lys Leu Ala Ser His Met Tyr Cys Ser Phe Tyr Pro Pro Asp

915 920 925

Glu Asp Glu Glu Glu Gly Asp Cys Glu Glu Glu Glu Phe Glu Pro Ser

930 935 940

Thr Gln Tyr Glu Tyr Gly Thr Glu Asp Asp Tyr Gln Gly Lys Pro Leu

945 950 955 960

Glu Phe Gly Ala Thr Ser Ala Ala Leu Gln Pro Glu Glu Glu Gln Glu

965 970 975

Glu Asp Trp Leu Asp Asp Asp Ser Gln Gln Thr Val Gly Gln Gln Asp

980 985 990

Gly Ser Glu Asp Asn Gln Thr Thr Thr Ile Gln Thr Ile Val Glu Val

995 1000 1005

Gln Pro Gln Leu Glu Met Glu Leu Thr Pro Val Val Gln Thr Ile

1010 1015 1020

Glu Val Asn Ser Phe Ser Gly Tyr Leu Lys Leu Thr Asp Asn Val

1025 1030 1035

Tyr Ile Lys Asn Ala Asp Ile Val Glu Glu Ala Lys Lys Val Lys

1040 1045 1050

Pro Thr Val Val Val Asn Ala Ala Asn Val Tyr Leu Lys His Gly

1055 1060 1065

Gly Gly Val Ala Gly Ala Leu Asn Lys Ala Thr Asn Asn Ala Met

1070 1075 1080

Gln Val Glu Ser Asp Asp Tyr Ile Ala Thr Asn Gly Pro Leu Lys

1085 1090 1095

Val Gly Gly Ser Cys Val Leu Ser Gly His Asn Leu Ala Lys His

1100 1105 1110

Cys Leu His Val Val Gly Pro Asn Val Asn Lys Gly Glu Asp Ile

1115 1120 1125

Gln Leu Leu Lys Ser Ala Tyr Glu Asn Phe Asn Gln His Glu Val

1130 1135 1140

Leu Leu Ala Pro Leu Leu Ser Ala Gly Ile Phe Gly Ala Asp Pro

1145 1150 1155

Ile His Ser Leu Arg Val Cys Val Asp Thr Val Arg Thr Asn Val

1160 1165 1170

Tyr Leu Ala Val Phe Asp Lys Asn Leu Tyr Asp Lys Leu Val Ser

1175 1180 1185

Ser Phe Leu Glu Met Lys Ser Glu Lys Gln Val Glu Gln Lys Ile

1190 1195 1200

Ala Glu Ile Pro Lys Glu Glu Val Lys Pro Phe Ile Thr Glu Ser

1205 1210 1215

Lys Pro Ser Val Glu Gln Arg Lys Gln Asp Asp Lys Lys Ile Lys

1220 1225 1230

Ala Cys Val Glu Glu Val Thr Thr Thr Leu Glu Glu Thr Lys Phe

1235 1240 1245

Leu Thr Glu Asn Leu Leu Leu Tyr Ile Asp Ile Asn Gly Asn Leu

1250 1255 1260

His Pro Asp Ser Ala Thr Leu Val Ser Asp Ile Asp Ile Thr Phe

1265 1270 1275

Leu Lys Lys Asp Ala Pro Tyr Ile Val Gly Asp Val Val Gln Glu

1280 1285 1290

Gly Val Leu Thr Ala Val Val Ile Pro Thr Lys Lys Ala Gly Gly

1295 1300 1305

Thr Thr Glu Met Leu Ala Lys Ala Leu Arg Lys Val Pro Thr Asp

1310 1315 1320

Asn Tyr Ile Thr Thr Tyr Pro Gly Gln Gly Leu Asn Gly Tyr Thr

1325 1330 1335

Val Glu Glu Ala Lys Thr Val Leu Lys Lys Cys Lys Ser Ala Phe

1340 1345 1350

Tyr Ile Leu Pro Ser Ile Ile Ser Asn Glu Lys Gln Glu Ile Leu

1355 1360 1365

Gly Thr Val Ser Trp Asn Leu Arg Glu Met Leu Ala His Ala Glu

1370 1375 1380

Glu Thr Arg Lys Leu Met Pro Val Cys Val Glu Thr Lys Ala Ile

1385 1390 1395

Val Ser Thr Ile Gln Arg Lys Tyr Lys Gly Ile Lys Ile Gln Glu

1400 1405 1410

Gly Val Val Asp Tyr Gly Ala Arg Phe Tyr Phe Tyr Thr Ser Lys

1415 1420 1425

Thr Thr Val Ala Ser Leu Ile Asn Thr Leu Asn Asp Leu Asn Glu

1430 1435 1440

Thr Leu Val Thr Met Pro Leu Gly Tyr Val Thr His Gly Leu Asn

1445 1450 1455

Leu Glu Glu Ala Ala Arg Tyr Met Arg Ser Leu Lys Val Pro Ala

1460 1465 1470

Thr Val Ser Val Ser Ser Pro Asp Ala Val Thr Ala Tyr Asn Gly

1475 1480 1485

Tyr Leu Thr Ser Ser Ser Lys Thr Pro Glu Glu His Phe Ile Glu

1490 1495 1500

Thr Ile Ser Leu Ala Gly Ser Tyr Lys Asp Trp Ser Tyr Ser Gly

1505 1510 1515

Gln Ser Thr Gln Leu Gly Ile Glu Phe Leu Lys Arg Gly Asp Lys

1520 1525 1530

Ser Val Tyr Tyr Thr Ser Asn Pro Thr Thr Phe His Leu Asp Gly

1535 1540 1545

Glu Val Ile Thr Phe Asp Asn Leu Lys Thr Leu Leu Ser Leu Arg

1550 1555 1560

Glu Val Arg Thr Ile Lys Val Phe Thr Thr Val Asp Asn Ile Asn

1565 1570 1575

Leu His Thr Gln Val Val Asp Met Ser Met Thr Tyr Gly Gln Gln

1580 1585 1590

Phe Gly Pro Thr Tyr Leu Asp Gly Ala Asp Val Thr Lys Ile Lys

1595 1600 1605

Pro His Asn Ser His Glu Gly Lys Thr Phe Tyr Val Leu Pro Asn

1610 1615 1620

Asp Asp Thr Leu Arg Val Glu Ala Phe Glu Tyr Tyr His Thr Thr

1625 1630 1635

Asp Pro Ser Phe Leu Gly Arg Tyr Met Ser Ala Leu Asn His Thr

1640 1645 1650

Lys Lys Trp Lys Tyr Pro Gln Val Asn Gly Leu Thr Ser Ile Lys

1655 1660 1665

Trp Ala Asp Asn Asn Cys Tyr Leu Ala Thr Ala Leu Leu Thr Leu

1670 1675 1680

Gln Gln Ile Glu Leu Lys Phe Asn Pro Pro Ala Leu Gln Asp Ala

1685 1690 1695

Tyr Tyr Arg Ala Arg Ala Gly Glu Ala Ala Asn Phe Cys Ala Leu

1700 1705 1710

Ile Leu Ala Tyr Cys Asn Lys Thr Val Gly Glu Leu Gly Asp Val

1715 1720 1725

Arg Glu Thr Met Ser Tyr Leu Phe Gln His Ala Asn Leu Asp Ser

1730 1735 1740

Cys Lys Arg Val Leu Asn Val Val Cys Lys Thr Cys Gly Gln Gln

1745 1750 1755

Gln Thr Thr Leu Lys Gly Val Glu Ala Val Met Tyr Met Gly Thr

1760 1765 1770

Leu Ser Tyr Glu Gln Phe Lys Lys Gly Val Gln Ile Pro Cys Thr

1775 1780 1785

Cys Gly Lys Gln Ala Thr Lys Tyr Leu Val Gln Gln Glu Ser Pro

1790 1795 1800

Phe Val Met Met Ser Ala Pro Pro Ala Gln Tyr Glu Leu Lys His

1805 1810 1815

Gly Thr Phe Thr Cys Ala Ser Glu Tyr Thr Gly Asn Tyr Gln Cys

1820 1825 1830

Gly His Tyr Lys His Ile Thr Ser Lys Glu Thr Leu Tyr Cys Ile

1835 1840 1845

Asp Gly Ala Leu Leu Thr Lys Ser Ser Glu Tyr Lys Gly Pro Ile

1850 1855 1860

Thr Asp Val Phe Tyr Lys Glu Asn Ser Tyr Thr Thr Thr Ile Lys

1865 1870 1875

Pro Val Thr Tyr Lys Leu Asp Gly Val Val Cys Thr Glu Ile Asp

1880 1885 1890

Pro Lys Leu Asp Asn Tyr Tyr Lys Lys Asp Asn Ser Tyr Phe Thr

1895 1900 1905

Glu Gln Pro Ile Asp Leu Val Pro Asn Gln Pro Tyr Pro Asn Ala

1910 1915 1920

Ser Phe Asp Asn Phe Lys Phe Val Cys Asp Asn Ile Lys Phe Ala

1925 1930 1935

Asp Asp Leu Asn Gln Leu Thr Gly Tyr Lys Lys Pro Ala Ser Arg

1940 1945 1950

Glu Leu Lys Val Thr Phe Phe Pro Asp Leu Asn Gly Asp Val Val

1955 1960 1965

Ala Ile Asp Tyr Lys His Tyr Thr Pro Ser Phe Lys Lys Gly Ala

1970 1975 1980

Lys Leu Leu His Lys Pro Ile Val Trp His Val Asn Asn Ala Thr

1985 1990 1995

Asn Lys Ala Thr Tyr Lys Pro Asn Thr Trp Cys Ile Arg Cys Leu

2000 2005 2010

Trp Ser Thr Lys Pro Val Glu Thr Ser Asn Ser Phe Asp Val Leu

2015 2020 2025

Lys Ser Glu Asp Ala Gln Gly Met Asp Asn Leu Ala Cys Glu Asp

2030 2035 2040

Leu Lys Pro Val Ser Glu Glu Val Val Glu Asn Pro Thr Ile Gln

2045 2050 2055

Lys Asp Val Leu Glu Cys Asn Val Lys Thr Thr Glu Val Val Gly

2060 2065 2070

Asp Ile Ile Leu Lys Pro Ala Asn Asn Ser Leu Lys Ile Thr Glu

2075 2080 2085

Glu Val Gly His Thr Asp Leu Met Ala Ala Tyr Val Asp Asn Ser

2090 2095 2100

Ser Leu Thr Ile Lys Lys Pro Asn Glu Leu Ser Arg Val Leu Gly

2105 2110 2115

Leu Lys Thr Leu Ala Thr His Gly Leu Ala Ala Val Asn Ser Val

2120 2125 2130

Pro Trp Asp Thr Ile Ala Asn Tyr Ala Lys Pro Phe Leu Asn Lys

2135 2140 2145

Val Val Ser Thr Thr Thr Asn Ile Val Thr Arg Cys Leu Asn Arg

2150 2155 2160

Val Cys Thr Asn Tyr Met Pro Tyr Phe Phe Thr Leu Leu Leu Gln

2165 2170 2175

Leu Cys Thr Phe Thr Arg Ser Thr Asn Ser Arg Ile Lys Ala Ser

2180 2185 2190

Met Pro Thr Thr Ile Ala Lys Asn Thr Val Lys Ser Val Gly Lys

2195 2200 2205

Phe Cys Leu Glu Ala Ser Phe Asn Tyr Leu Lys Ser Pro Asn Phe

2210 2215 2220

Ser Lys Leu Ile Asn Ile Ile Ile Trp Phe Leu Leu Leu Ser Val

2225 2230 2235

Cys Leu Gly Ser Leu Ile Tyr Ser Thr Ala Ala Leu Gly Val Leu

2240 2245 2250

Met Ser Asn Leu Gly Met Pro Ser Tyr Cys Thr Gly Tyr Arg Glu

2255 2260 2265

Gly Tyr Leu Asn Ser Thr Asn Val Thr Ile Ala Thr Tyr Cys Thr

2270 2275 2280

Gly Ser Ile Pro Cys Ser Val Cys Leu Ser Gly Leu Asp Ser Leu

2285 2290 2295

Asp Thr Tyr Pro Ser Leu Glu Thr Ile Gln Ile Thr Ile Ser Ser

2300 2305 2310

Phe Lys Trp Asp Leu Thr Ala Phe Gly Leu Val Ala Glu Trp Phe

2315 2320 2325

Leu Ala Tyr Ile Leu Phe Thr Arg Phe Phe Tyr Val Leu Gly Leu

2330 2335 2340

Ala Ala Ile Met Gln Leu Phe Phe Ser Tyr Phe Ala Val His Phe

2345 2350 2355

Ile Ser Asn Ser Trp Leu Met Trp Leu Ile Ile Asn Leu Val Gln

2360 2365 2370

Met Ala Pro Ile Ser Ala Met Val Arg Met Tyr Ile Phe Phe Ala

2375 2380 2385

Ser Phe Tyr Tyr Val Trp Lys Ser Tyr Val His Val Val Asp Gly

2390 2395 2400

Cys Asn Ser Ser Thr Cys Met Met Cys Tyr Lys Arg Asn Arg Ala

2405 2410 2415

Thr Arg Val Glu Cys Thr Thr Ile Val Asn Gly Val Arg Arg Ser

2420 2425 2430

Phe Tyr Val Tyr Ala Asn Gly Gly Lys Gly Phe Cys Lys Leu His

2435 2440 2445

Asn Trp Asn Cys Val Asn Cys Asp Thr Phe Cys Ala Gly Ser Thr

2450 2455 2460

Phe Ile Ser Asp Glu Val Ala Arg Asp Leu Ser Leu Gln Phe Lys

2465 2470 2475

Arg Pro Ile Asn Pro Thr Asp Gln Ser Ser Tyr Ile Val Asp Ser

2480 2485 2490

Val Thr Val Lys Asn Gly Ser Ile His Leu Tyr Phe Asp Lys Ala

2495 2500 2505

Gly Gln Lys Thr Tyr Glu Arg His Ser Leu Ser His Phe Val Asn

2510 2515 2520

Leu Asp Asn Leu Arg Ala Asn Asn Thr Lys Gly Ser Leu Pro Ile

2525 2530 2535

Asn Val Ile Val Phe Asp Gly Lys Ser Lys Cys Glu Glu Ser Ser

2540 2545 2550

Ala Lys Ser Ala Ser Val Tyr Tyr Ser Gln Leu Met Cys Gln Pro

2555 2560 2565

Ile Leu Leu Leu Asp Gln Ala Leu Val Ser Asp Val Gly Asp Ser

2570 2575 2580

Ala Glu Val Ala Val Lys Met Phe Asp Ala Tyr Val Asn Thr Phe

2585 2590 2595

Ser Ser Thr Phe Asn Val Pro Met Glu Lys Leu Lys Thr Leu Val

2600 2605 2610

Ala Thr Ala Glu Ala Glu Leu Ala Lys Asn Val Ser Leu Asp Asn

2615 2620 2625

Val Leu Ser Thr Phe Ile Ser Ala Ala Arg Gln Gly Phe Val Asp

2630 2635 2640

Ser Asp Val Glu Thr Lys Asp Val Val Glu Cys Leu Lys Leu Ser

2645 2650 2655

His Gln Ser Asp Ile Glu Val Thr Gly Asp Ser Cys Asn Asn Tyr

2660 2665 2670

Met Leu Thr Tyr Asn Lys Val Glu Asn Met Thr Pro Arg Asp Leu

2675 2680 2685

Gly Ala Cys Ile Asp Cys Ser Ala Arg His Ile Asn Ala Gln Val

2690 2695 2700

Ala Lys Ser His Asn Ile Ala Leu Ile Trp Asn Val Lys Asp Phe

2705 2710 2715

Met Ser Leu Ser Glu Gln Leu Arg Lys Gln Ile Arg Ser Ala Ala

2720 2725 2730

Lys Lys Asn Asn Leu Pro Phe Lys Leu Thr Cys Ala Thr Thr Arg

2735 2740 2745

Gln Val Val Asn Val Val Thr Thr Lys Ile Ala Leu Lys Gly Gly

2750 2755 2760

Lys Ile Val Asn Asn Trp Leu Lys Gln Leu Ile Lys Val Thr Leu

2765 2770 2775

Val Phe Leu Phe Val Ala Ala Ile Phe Tyr Leu Ile Thr Pro Val

2780 2785 2790

His Val Met Ser Lys His Thr Asp Phe Ser Ser Glu Ile Ile Gly

2795 2800 2805

Tyr Lys Ala Ile Asp Gly Gly Val Thr Arg Asp Ile Ala Ser Thr

2810 2815 2820

Asp Thr Cys Phe Ala Asn Lys His Ala Asp Phe Asp Thr Trp Phe

2825 2830 2835

Ser Gln Arg Gly Gly Ser Tyr Thr Asn Asp Lys Ala Cys Pro Leu

2840 2845 2850

Ile Ala Ala Val Ile Thr Arg Glu Val Gly Phe Val Val Pro Gly

2855 2860 2865

Leu Pro Gly Thr Ile Leu Arg Thr Thr Asn Gly Asp Phe Leu His

2870 2875 2880

Phe Leu Pro Arg Val Phe Ser Ala Val Gly Asn Ile Cys Tyr Thr

2885 2890 2895

Pro Ser Lys Leu Ile Glu Tyr Thr Asp Phe Ala Thr Ser Ala Cys

2900 2905 2910

Val Leu Ala Ala Glu Cys Thr Ile Phe Lys Asp Ala Ser Gly Lys

2915 2920 2925

Pro Val Pro Tyr Cys Tyr Asp Thr Asn Val Leu Glu Gly Ser Val

2930 2935 2940

Ala Tyr Glu Ser Leu Arg Pro Asp Thr Arg Tyr Val Leu Met Asp

2945 2950 2955

Gly Ser Ile Ile Gln Phe Pro Asn Thr Tyr Leu Glu Gly Ser Val

2960 2965 2970

Arg Val Val Thr Thr Phe Asp Ser Glu Tyr Cys Arg His Gly Thr

2975 2980 2985

Cys Glu Arg Ser Glu Ala Gly Val Cys Val Ser Thr Ser Gly Arg

2990 2995 3000

Trp Val Leu Asn Asn Asp Tyr Tyr Arg Ser Leu Pro Gly Val Phe

3005 3010 3015

Cys Gly Val Asp Ala Val Asn Leu Leu Thr Asn Met Phe Thr Pro

3020 3025 3030

Leu Ile Gln Pro Ile Gly Ala Leu Asp Ile Ser Ala Ser Ile Val

3035 3040 3045

Ala Gly Gly Ile Val Ala Ile Val Val Thr Cys Leu Ala Tyr Tyr

3050 3055 3060

Phe Met Arg Phe Arg Arg Ala Phe Gly Glu Tyr Ser His Val Val

3065 3070 3075

Ala Phe Asn Thr Leu Leu Phe Leu Met Ser Phe Thr Val Leu Cys

3080 3085 3090

Leu Thr Pro Val Tyr Ser Phe Leu Pro Gly Val Tyr Ser Val Ile

3095 3100 3105

Tyr Leu Tyr Leu Thr Phe Tyr Leu Thr Asn Asp Val Ser Phe Leu

3110 3115 3120

Ala His Ile Gln Trp Met Val Met Phe Thr Pro Leu Val Pro Phe

3125 3130 3135

Trp Ile Thr Ile Ala Tyr Ile Ile Cys Ile Ser Thr Lys His Phe

3140 3145 3150

Tyr Trp Phe Phe Ser Asn Tyr Leu Lys Arg Arg Val Val Phe Asn

3155 3160 3165

Gly Val Ser Phe Ser Thr Phe Glu Glu Ala Ala Leu Cys Thr Phe

3170 3175 3180

Leu Leu Asn Lys Glu Met Tyr Leu Lys Leu Arg Ser Asp Val Leu

3185 3190 3195

Leu Pro Leu Thr Gln Tyr Asn Arg Tyr Leu Ala Leu Tyr Asn Lys

3200 3205 3210

Tyr Lys Tyr Phe Ser Gly Ala Met Asp Thr Thr Ser Tyr Arg Glu

3215 3220 3225

Ala Ala Cys Cys His Leu Ala Lys Ala Leu Asn Asp Phe Ser Asn

3230 3235 3240

Ser Gly Ser Asp Val Leu Tyr Gln Pro Pro Gln Thr Ser Ile Thr

3245 3250 3255

Ser Ala Val Leu Gln Ser Gly Phe Arg Lys Met Ala Phe Pro Ser

3260 3265 3270

Gly Lys Val Glu Gly Cys Met Val Gln Val Thr Cys Gly Thr Thr

3275 3280 3285

Thr Leu Asn Gly Leu Trp Leu Asp Asp Val Val Tyr Cys Pro Arg

3290 3295 3300

His Val Ile Cys Thr Ser Glu Asp Met Leu Asn Pro Asn Tyr Glu

3305 3310 3315

Asp Leu Leu Ile Arg Lys Ser Asn His Asn Phe Leu Val Gln Ala

3320 3325 3330

Gly Asn Val Gln Leu Arg Val Ile Gly His Ser Met Gln Asn Cys

3335 3340 3345

Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro Lys Thr Pro Lys

3350 3355 3360

Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Phe Ser Val Leu

3365 3370 3375

Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys Ala Met

3380 3385 3390

Arg Pro Asn Phe Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser Cys

3395 3400 3405

Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys

3410 3415 3420

Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr

3425 3430 3435

Asp Leu Glu Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr

3440 3445 3450

Ala Gln Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu

3455 3460 3465

Ala Trp Leu Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu

3470 3475 3480

Asn Arg Phe Thr Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met

3485 3490 3495

Lys Tyr Asn Tyr Glu Pro Leu Thr Gln Asp His Val Asp Ile Leu

3500 3505 3510

Gly Pro Leu Ser Ala Gln Thr Gly Ile Ala Val Leu Asp Met Cys

3515 3520 3525

Ala Ser Leu Lys Glu Leu Leu Gln Asn Gly Met Asn Gly Arg Thr

3530 3535 3540

Ile Leu Gly Ser Ala Leu Leu Glu Asp Glu Phe Thr Pro Phe Asp

3545 3550 3555

Val Val Arg Gln Cys Ser Gly Val Thr Phe Gln Ser Ala Val Lys

3560 3565 3570

Arg Thr Ile Lys Gly Thr His His Trp Leu Leu Leu Thr Ile Leu

3575 3580 3585

Thr Ser Leu Leu Val Leu Val Gln Ser Thr Gln Trp Ser Leu Phe

3590 3595 3600

Phe Phe Leu Tyr Glu Asn Ala Phe Leu Pro Phe Ala Met Gly Ile

3605 3610 3615

Ile Ala Met Ser Ala Phe Ala Met Met Phe Val Lys His Lys His

3620 3625 3630

Ala Phe Leu Cys Leu Phe Leu Leu Pro Ser Leu Ala Thr Val Ala

3635 3640 3645

Tyr Phe Asn Met Val Tyr Met Pro Ala Ser Trp Val Met Arg Ile

3650 3655 3660

Met Thr Trp Leu Asp Met Val Asp Thr Ser Leu Ser Gly Phe Lys

3665 3670 3675

Leu Lys Asp Cys Val Met Tyr Ala Ser Ala Val Val Leu Leu Ile

3680 3685 3690

Leu Met Thr Ala Arg Thr Val Tyr Asp Asp Gly Ala Arg Arg Val

3695 3700 3705

Trp Thr Leu Met Asn Val Leu Thr Leu Val Tyr Lys Val Tyr Tyr

3710 3715 3720

Gly Asn Ala Leu Asp Gln Ala Ile Ser Met Trp Ala Leu Ile Ile

3725 3730 3735

Ser Val Thr Ser Asn Tyr Ser Gly Val Val Thr Thr Val Met Phe

3740 3745 3750

Leu Ala Arg Gly Ile Val Phe Met Cys Val Glu Tyr Cys Pro Ile

3755 3760 3765

Phe Phe Ile Thr Gly Asn Thr Leu Gln Cys Ile Met Leu Val Tyr

3770 3775 3780

Cys Phe Leu Gly Tyr Phe Cys Thr Cys Tyr Phe Gly Leu Phe Cys

3785 3790 3795

Leu Leu Asn Arg Tyr Phe Arg Leu Thr Leu Gly Val Tyr Asp Tyr

3800 3805 3810

Leu Val Ser Thr Gln Glu Phe Arg Tyr Met Asn Ser Gln Gly Leu

3815 3820 3825

Leu Pro Pro Lys Asn Ser Ile Asp Ala Phe Lys Leu Asn Ile Lys

3830 3835 3840

Leu Leu Gly Val Gly Gly Lys Pro Cys Ile Lys Val Ala Thr Val

3845 3850 3855

Gln Ser Lys Met Ser Asp Val Lys Cys Thr Ser Val Val Leu Leu

3860 3865 3870

Ser Val Leu Gln Gln Leu Arg Val Glu Ser Ser Ser Lys Leu Trp

3875 3880 3885

Ala Gln Cys Val Gln Leu His Asn Asp Ile Leu Leu Ala Lys Asp

3890 3895 3900

Thr Thr Glu Ala Phe Glu Lys Met Val Ser Leu Leu Ser Val Leu

3905 3910 3915

Leu Ser Met Gln Gly Ala Val Asp Ile Asn Lys Leu Cys Glu Glu

3920 3925 3930

Met Leu Asp Asn Arg Ala Thr Leu Gln Ala Ile Ala Ser Glu Phe

3935 3940 3945

Ser Ser Leu Pro Ser Tyr Ala Ala Phe Ala Thr Ala Gln Glu Ala

3950 3955 3960

Tyr Glu Gln Ala Val Ala Asn Gly Asp Ser Glu Val Val Leu Lys

3965 3970 3975

Lys Leu Lys Lys Ser Leu Asn Val Ala Lys Ser Glu Phe Asp Arg

3980 3985 3990

Asp Ala Ala Met Gln Arg Lys Leu Glu Lys Met Ala Asp Gln Ala

3995 4000 4005

Met Thr Gln Met Tyr Lys Gln Ala Arg Ser Glu Asp Lys Arg Ala

4010 4015 4020

Lys Val Thr Ser Ala Met Gln Thr Met Leu Phe Thr Met Leu Arg

4025 4030 4035

Lys Leu Asp Asn Asp Ala Leu Asn Asn Ile Ile Asn Asn Ala Arg

4040 4045 4050

Asp Gly Cys Val Pro Leu Asn Ile Ile Pro Leu Thr Thr Ala Ala

4055 4060 4065

Lys Leu Met Val Val Ile Pro Asp Tyr Asn Thr Tyr Lys Asn Thr

4070 4075 4080

Cys Asp Gly Thr Thr Phe Thr Tyr Ala Ser Ala Leu Trp Glu Ile

4085 4090 4095

Gln Gln Val Val Asp Ala Asp Ser Lys Ile Val Gln Leu Ser Glu

4100 4105 4110

Ile Ser Met Asp Asn Ser Pro Asn Leu Ala Trp Pro Leu Ile Val

4115 4120 4125

Thr Ala Leu Arg Ala Asn Ser Ala Val Lys Leu Gln Asn Asn Glu

4130 4135 4140

Leu Ser Pro Val Ala Leu Arg Gln Met Ser Cys Ala Ala Gly Thr

4145 4150 4155

Thr Gln Thr Ala Cys Thr Asp Asp Asn Ala Leu Ala Tyr Tyr Asn

4160 4165 4170

Thr Thr Lys Gly Gly Arg Phe Val Leu Ala Leu Leu Ser Asp Leu

4175 4180 4185

Gln Asp Leu Lys Trp Ala Arg Phe Pro Lys Ser Asp Gly Thr Gly

4190 4195 4200

Thr Ile Tyr Thr Glu Leu Glu Pro Pro Cys Arg Phe Val Thr Asp

4205 4210 4215

Thr Pro Lys Gly Pro Lys Val Lys Tyr Leu Tyr Phe Ile Lys Gly

4220 4225 4230

Leu Asn Asn Leu Asn Arg Gly Met Val Leu Gly Ser Leu Ala Ala

4235 4240 4245

Thr Val Arg Leu Gln Ala Gly Asn Ala Thr Glu Val Pro Ala Asn

4250 4255 4260

Ser Thr Val Leu Ser Phe Cys Ala Phe Ala Val Asp Ala Ala Lys

4265 4270 4275

Ala Tyr Lys Asp Tyr Leu Ala Ser Gly Gly Gln Pro Ile Thr Asn

4280 4285 4290

Cys Val Lys Met Leu Cys Thr His Thr Gly Thr Gly Gln Ala Ile

4295 4300 4305

Thr Val Thr Pro Glu Ala Asn Met Asp Gln Glu Ser Phe Gly Gly

4310 4315 4320

Ala Ser Cys Cys Leu Tyr Cys Arg Cys His Ile Asp His Pro Asn

4325 4330 4335

Pro Lys Gly Phe Cys Asp Leu Lys Gly Lys Tyr Val Gln Ile Pro

4340 4345 4350

Thr Thr Cys Ala Asn Asp Pro Val Gly Phe Thr Leu Lys Asn Thr

4355 4360 4365

Val Cys Thr Val Cys Gly Met Trp Lys Gly Tyr Gly Cys Ser Cys

4370 4375 4380

Asp Gln Leu Arg Glu Pro Met Leu Gln Ser Ala Asp Ala Gln Ser

4385 4390 4395

Phe Leu Asn Gly Phe Ala Val

4400 4405

<210> 17

<211> 1273

<212> PRT

<213> SARS-CoV2

<220>

<221> UNSURE

<222> (320)..(320)

<223> Xaa can be any naturally occurring amino acid

<220>

<221> UNSURE

<222> (709)..(709)

<223> Xaa can be any naturally occurring amino acid

<400> 17

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val

1 5 10 15

Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe

20 25 30

Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu

35 40 45

His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp

50 55 60

Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp

65 70 75 80

Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu

85 90 95

Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser

100 105 110

Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile

115 120 125

Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr

130 135 140

Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr

145 150 155 160

Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu

165 170 175

Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe

180 185 190

Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr

195 200 205

Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu

210 215 220

Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr

225 230 235 240

Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser

245 250 255

Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro

260 265 270

Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala

275 280 285

Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys

290 295 300

Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Xaa

305 310 315 320

Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys

325 330 335

Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala

340 345 350

Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu

355 360 365

Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro

370 375 380

Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe

385 390 395 400

Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly

405 410 415

Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys

420 425 430

Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn

435 440 445

Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe

450 455 460

Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys

465 470 475 480

Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly

485 490 495

Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val

500 505 510

Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys

515 520 525

Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn

530 535 540

Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu

545 550 555 560

Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val

565 570 575

Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe

580 585 590

Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val

595 600 605

Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile

610 615 620

His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser

625 630 635 640

Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val

645 650 655

Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala

660 665 670

Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala

675 680 685

Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser

690 695 700

Val Ala Tyr Ser Xaa Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile

705 710 715 720

Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val

725 730 735

Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu

740 745 750

Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr

755 760 765

Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln

770 775 780

Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe

785 790 795 800

Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser

805 810 815

Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly

820 825 830

Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp

835 840 845

Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu

850 855 860

Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly

865 870 875 880

Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile

885 890 895

Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr

900 905 910

Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn

915 920 925

Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala

930 935 940

Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn

945 950 955 960

Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val

965 970 975

Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln

980 985 990

Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val

995 1000 1005

Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Val Ser Ala Asn

1010 1015 1020

Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys

1025 1030 1035

Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro

1040 1045 1050

Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val

1055 1060 1065

Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His

1070 1075 1080

Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn

1085 1090 1095

Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln

1100 1105 1110

Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val

1115 1120 1125

Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro

1130 1135 1140

Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn

1145 1150 1155

His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn

1160 1165 1170

Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu

1175 1180 1185

Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu

1190 1195 1200

Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu

1205 1210 1215

Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met

1220 1225 1230

Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys

1235 1240 1245

Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro

1250 1255 1260

Val Leu Lys Gly Val Lys Leu His Tyr Thr

1265 1270

<210> 18

<211> 29897

<212> DNA

<213> SARS-CoV2

<220>

<221> misc_feature

<222> (11288)..(11293)

<223> n is a, c, g or t

<220>

<221> misc_feature

<222> (22278)..(22283)

<223> n is a, c, g or t

<220>

<221> misc_feature

<222> (29836)..(29864)

<223> n is a, c, g or t

<400> 18

attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct 60

gttctctaaa cgaactttaa aatctgtgtg gctgtcactc ggctgcatgc ttagtgcact 120

cacgcagtat aattaataac taattactgt cgttgacagg acacgagtaa ctcttctatc 180

ttctgcaggc tgcttacggt ttcgtccgtg ttgcagccga tcatcagcac atctaggttt 240

tgtccgggtg tgaccgaaag gtaagatgga gagccttgtc cctggtttca acgagaaaac 300

acacgtccaa ctcagtttgc ctgttttaca ggttcgcgac gtgctcgtac gtggctttgg 360

agactccgtg gaggaggtct tatcagaggc acgtcaacat cttaaagatg gcacttgtgg 420

cttagtagaa gttgaaaaag gcgttttgcc tcaacttgaa cagccctatg tgttcatcaa 480

acgttcggat gctcgaactg cacctcatgg tcatgttatg gttgagctgg tagcagaact 540

cgaaggcatt cagtacggtc gtagtggtga gacacttggt gtccttgtcc ctcatgtggg 600

cgaaatacca gtggcttacc gcaaggttct tcttcgtaag aacggtaata aaggagctgg 660

tggccatagt tacggcgccg atctaaagtc atttgactta ggcgacgagc ttggcactga 720

tccttatgaa gattttcaag aaaactggaa cactaaacat agcagtggtg ttacccgtga 780

actcatgcgt gagcttaacg gaggggcata cactcgctat gtcgataaca acttctgtgg 840

ccctgatggc taccctcttg agtgcattaa agaccttcta gcacgtgctg gtaaagcttc 900

atgcactttg tccgaacaac tggactttat tgacactaag aggggtgtat actgctgccg 960

tgaacatgag catgaaattg cttggtacac ggaacgttct gaaaagagct atgaattgca 1020

gacacctttt gaaattaaat tggcaaagaa atttgacatc ttcaatgggg aatgtccaaa 1080

ttttgtattt cccttaaatt ccataatcaa gactattcaa ccaagggttg aaaagaaaaa 1140

gcttgatggc tttatgggta gaattcgatc tgtctatcca gttgcgtcac caaatgaatg 1200

caaccaaatg tgcctttcaa ctctcatgaa gtgtgatcat tgtggtgaaa cttcatggca 1260

gacgggcgat tttgttaaag ccacttgcga attttgtggc actgagaatt tgactaaaga 1320

aggtgccact acttgtggtt acttacccca aaatgctgtt gttaaaattt attgtccagc 1380

atgtcacaat tcagaagtag gacctgagca tagtcttgcc gaataccata atgaatctgg 1440

cttgaaaacc attcttcgta agggtggtcg cactattgcc tttggaggct gtgtgttctc 1500

ttatgttggt tgccataaca agtgtgccta ttgggttcca cgtgctagcg ctaacatagg 1560

ttgtaaccat acaggtgttg ttggagaagg ttccgaaggt cttaatgaca accttcttga 1620

aatactccaa aaagagaaag tcaacatcaa tattgttggt gactttaaac ttaatgaaga 1680

gatcgccatt attttggcat ctttttctgc ttccacaagt gcttttgtgg aaactgtgaa 1740

aggtttggat tataaagcat tcaaacaaat tgttgaatcc tgtggtaatt ttaaagttac 1800

aaaaggaaaa gctaaaaaag gtgcctggaa tattggtgaa cagaaatcaa tactgagtcc 1860

tctttatgca tttgcatcag aggctgctcg tgttgtacga tcaattttct cccgcactct 1920

tgaaactgct caaaattctg tgcgtgtttt acagaaggcc gctataacaa tactagatgg 1980

aatttcacag tattcactga gactcattga tgctatgatg ttcacatctg atttggctac 2040

taacaatcta gttgtaatgg cctacattac aggtggtgtt gttcagttga cttcgcagtg 2100

gctaactaac atctttggca ctgtttatga aaaactcaaa cccgtccttg attggcttga 2160

agagaagttt aaggaaggtg tagagtttct tagagacggt tgggaaattg ttaaatttat 2220

ctcaacctgt gcttgtgaaa ttgtcggtgg acaaattgtc acctgtgcaa aggaaattaa 2280

ggagagtgtt cagacattct ttaagcttgt aaataaattt ttggctttgt gtgctgactc 2340

tatcattatt ggtggagcta aacttaaagc cttgaattta ggtgaaacat ttgtcacgca 2400

ctcaaaggga ttgtacagaa agtgtgttaa atccagagaa gaaactggcc tactcatgcc 2460

tctaaaagcc ccaaaagaaa ttatcttctt agagggagaa acacttccca cagaagtgtt 2520

aacagaggaa gttgtcttga aaactggtga tttacaacca ttagaacaac ctactagtga 2580

agctgttgaa gctccattgg ttggtacacc agtttgtatt aacgggctta tgttgctcga 2640

aatcaaagac acagaaaagt actgtgccct tgcacctaat atgatggtaa ctaacaatac 2700

cttcacactc aaaggcggtg caccaacaaa ggttactttt ggtgatgaca ctgtgataga 2760

agtgcaaggt tacaagagtg tgaatatcac ttttgaactt gatgaaagga ttgataaagt 2820

acttaatgag aagtgctctg cctatacagt tgaactcggt acagaagtaa atgagttcgc 2880

ctgtgttgtg gcagatgctg tcataaaaac tttgcaacca gtatctgaat tacttacacc 2940

actgggcatt gatttagatg agtggagtat ggctacatac tacttatttg atgagtctgg 3000

tgagtttaaa ttggcttcac atatgtattg ttctttttac cctccagatg aggatgaaga 3060

agaaggtgat tgtgaagaag aagagtttga gccatcaact caatatgagt atggtactga 3120

agatgattac caaggtaaac ctttggaatt tggtgccact tctgctgctc ttcaacctga 3180

agaagagcaa gaagaagatt ggttagatga tgatagtcaa caaactgttg gtcaacaaga 3240

cggcagtgag gacaatcaga caactactat tcaaacaatt gttgaggttc aacctcaatt 3300

agagatggaa cttacaccag ttgttcagac tattgaagtg aatagtttta gtggttattt 3360

aaaacttact gacaatgtat acattaaaaa tgcagacatt gtggaagaag ctaaaaaggt 3420

aaaaccaaca gtggttgtta atgcagccaa tgtttacctt aaacatggag gaggtgttgc 3480

aggagcctta aataaggcta ctaacaatgc catgcaagtt gaatctgatg attacatagc 3540

tactaatgga ccacttaaag tgggtggtag ttgtgtttta agcggacaca atcttgctaa 3600

acactgtctt catgttgtcg gcccaaatgt taacaaaggt gaagacattc aacttcttaa 3660

gagtgcttat gaaaatttta atcagcacga agttctactt gcaccattat tatcagctgg 3720

tatttttggt gctgacccta tacattcttt aagagtttgt gtagatactg ttcgcacaaa 3780

tgtctactta gctgtctttg ataaaaatct ctatgacaaa cttgtttcaa gctttttgga 3840

aatgaagagt gaaaagcaag ttgaacaaaa gatcgctgag attcctaaag aggaagttaa 3900

gccatttata actgaaagta aaccttcagt tgaacagaga aaacaagatg ataagaaaat 3960

caaagcttgt gttgaagaag ttacaacaac tctggaagaa actaagttcc tcacagaaaa 4020

cttgttactt tatattgaca ttaatggcaa tcttcatcca gattctgcca ctcttgttag 4080

tgacattgac atcactttct taaagaaaga tgctccatat atagtgggtg atgttgttca 4140

agagggtgtt ttaactgctg tggttatacc tactaaaaag gctggtggca ctactgaaat 4200

gttagcgaaa gctttgagaa aagtgccaac agacaattat ataaccactt acccgggtca 4260

gggtttaaat ggttacactg tagaggaggc aaagacagtg cttaaaaagt gtaaaagtgc 4320

cttttacatt ctaccatcta ttatctctaa tgagaagcaa gaaattcttg gaactgtttc 4380

ttggaatttg cgagaaatgc ttgcacatgc agaagaaaca cgcaaattaa tgcctgtctg 4440

tgtggaaact aaagccatag tttcaactat acagcgtaaa tataagggta ttaaaataca 4500

agagggtgtg gttgattatg gtgctagatt ttacttttac accagtaaaa caactgtagc 4560

gtcacttatc aacacactta acgatctaaa tgaaactctt gttacaatgc cacttggcta 4620

tgtaacacat ggcttaaatt tggaagaagc tgctcggtat atgagatctc tcaaagtgcc 4680

agctacagtt tctgtttctt cacctgatgc tgttacagcg tataatggtt atcttacttc 4740

ttcttctaaa acacctgaag aacattttat tgaaaccatc tcacttgctg gttcctataa 4800

agattggtcc tattctggac aatctacaca actaggtata gaatttctta agagaggtga 4860

taaaagtgta tattacacta gtaatcctac cacattccac ctagatggtg aagttatcac 4920

ctttgacaat cttaagacac ttctttcttt gagagaagtg aggactatta aggtgtttac 4980

aacagtagac aacattaacc tccacacgca agttgtggac atgtcaatga catatggaca 5040

acagtttggt ccaacttatt tggatggagc tgatgttact aaaataaaac ctcataattc 5100

acatgaaggt aaaacatttt atgttttacc taatgatgac actctacgtg ttgaggcttt 5160

tgagtactac cacacaactg atcctagttt tctgggtagg tacatgtcag cattaaatca 5220

cactaaaaat tggaaatacc cacaagttaa tggtttaact tctattaaat gggcagataa 5280

caactgttat cttgccactg cattgttaac actccaacaa atagagttga agtttaatcc 5340

acctgctcta caagatgctt attacagagc aagggctggt gaagctgcta acttttgtgc 5400

acttatctta gcctactgta ataagacagt aggtgagtta ggtgatgtta gagaaacaat 5460

gagttacttg tttcaacatg ccaatttaga ttcttgcaaa agagtcttga acgtggtgtg 5520

taaaacttgt ggacaacagc agacaaccct taagggtgta gaagctgtta tgtacatggg 5580

cacactttct tatgaacaat ttaagaaagg tgttcagata ccttgtacgt gtggtaaaca 5640

agctacaaaa tatctagtac aacaggagtc accttttgtt atgatgtcag caccacctgc 5700

tcagtatgaa cttaagcatg gtacatttac ttgtgctagt gagtacactg gtaattacca 5760

gtgtggtcac tataaacata taacttctaa agaaactttg tattgcatag acggtgcttt 5820

acttacaaag tcctcagaat acaaaggtcc tattacggat gttttctaca aagaaaacag 5880

ttacacaaca accataaaac cagttactta taaattggat ggtgttgttt gtacagaaat 5940

tgaccctaag ttggacaatt attataagaa agacaattct tatttcacag agcaaccaat 6000

tgatcttgta ccaaaccaac catatccaaa cgcaagcttc gataatttta agtttgtatg 6060

tgataatatc aaatttgctg atgatttaaa ccagttaact ggttacaaga aacctgcttc 6120

aagagagctt aaagttacat ttttccctga cttaaatggt gatgtggtgg ctattgatta 6180

taaacactac acaccctctt ttaagaaagg agctaaattg ttacataaac ctattgtttg 6240

gcatgttaac aatgcaacta ataaagccac gtataaacca aatacctggt gtatacgttg 6300

tctttggagc acaaaaccag ttgaaacatc aaattcgttt gatgtactga agtcagagga 6360

cgcgcaggga atggataatc ttgcctgcga agatctaaaa ccagtctctg aagaagtagt 6420

ggaaaatcct accatacaga aagacgttct tgagtgtaat gtgaaaacta ccgaagttgt 6480

aggagacatt atacttaaac cagcaaataa tagtttaaaa attacagaag aggttggcca 6540

cacagatcta atggctgctt atgtagacaa ttctagtctt actattaaga aacctaatga 6600

attatctaga gtattaggtt tgaaaaccct tgctactcat ggtttagctg ctgttaatag 6660

tgtcccttgg gatactatag ctaattatgc taagcctttt cttaacaaag ttgttagtac 6720

aactactaac atagttacac ggtgtttaaa ccgtgtttgt actaattata tgccttattt 6780

ctttacttta ttgctacaat tgtgtacttt tactagaagt acaaattcta gaattaaagc 6840

atctatgccg actactatag caaagaatac tgttaagagt gtcggtaaat tttgtctaga 6900

ggcttcattt aattatttga agtcacctaa tttttctaaa ctgataaata ttataatttg 6960

gtttttacta ttaagtgttt gcctaggttc tttaatmtac tcaaccgctg ctttaggtgt 7020

tttaatgtct aatttaggca tgccttctta ctgtactggt tacagagaag gctatttgaa 7080

ctctactaat gtcactattg caacctactg tactggttct ataccttgta gtgtttgtct 7140

tagtggttta gattctttag acacctatcc ttctttagaa actatacaaa ttaccatttc 7200

atcttttaaa tgggatttaa ctgcttttgg cttagttgca gagtggtttt tggcatatat 7260

tcttttcact aggtttttct atgtacttgg attggctgca atcatgcaat tgtttttcag 7320

ctattttgca gtacatttta ttagtaattc ttggcttatg tggttaataa ttaatcttgt 7380

acaaatggcc ccgatttcag ctatggttag aatgtacatc ttctttgcat cattttatta 7440

tgtatggaaa agttatgtgc atgttgtaga cggttgtaat tcatcaactt gtatgatgtg 7500

ttacaaacgt aatagagcaa caagagtcga atgtacaact attgttaatg gtgttagaag 7560

gtccttttat gtctatgcta atggaggtaa aggcttttgc aaactacaca attggaattg 7620

tgttaattgt gatacattct gtgctggtag tacatttatt agtgatgaag ttgcgagaga 7680

cttgtcacta cagtttaaaa gaccaataaa tcctactgac cagtcttctt acatcgttga 7740

tagtgttaca gtgaagaatg gttccatcca tctttacttt gataaagctg gtcaaaagac 7800

ttatgaaaga cattctctct ctcattttgt taacttagac aacctgagag ctaataacac 7860

taaaggttca ttgcctatta atgttatagt ttttgatggt aaatcaaaat gtgaagaatc 7920

atctgcaaaa tcagcgtctg tttactacag tcagcttatg tgtcaaccta tactgttact 7980

agatcaggca ttagtgtctg atgttggtga tagtgcggaa gttgcagtta aaatgtttga 8040

tgcttacgtt aatacgtttt catcaacttt taacgtacca atggaaaaac tcaaaacact 8100

agttgcaact gcagaagctg aacttgcaaa gaatgtgtcc ttagacaatg tcttatctac 8160

ttttatttca gcagctcggc aagggtttgt tgattcagat gtagaaacta aagatgttgt 8220

tgaatgtctt aaattgtcac atcaatctga catagaagtt actggcgata gttgtaataa 8280

ctatatgctc acctataaca aagttgaaaa catgacaccc cgtgaccttg gtgcttgtat 8340

tgactgtagt gcgcgtcata ttaatgcgca ggtagcaaaa agtcacaaca ttgctttgat 8400

atggaacgtt aaagatttca tgtcattgtc tgaacaacta cgaaaacaaa tacgtagtgc 8460

tgctaaaaag aataacttac cttttaagtt gacatgtgca actactagac aagttgttaa 8520

tgttgtaaca acaaagatag cacttaaggg tggtaaaatt gttaataatt ggttgaagca 8580

gttaattaaa gttacacttg tgttcctttt tgttgctgct attttctatt taataacacc 8640

tgttcatgtc atgtctaaac atactgactt ttcaagtgaa atcataggat acaaggctat 8700

tgatggtggt gtcactcgtg acatagcatc tacagatact tgttttgcta acaaacatgc 8760

tgattttgac acatggttta gccagcgtgg tggtagttat actaatgaca aagcttgccc 8820

attgattgct gcagtcataa caagagaagt gggttttgtc gtgcctggtt tgcctggcac 8880

gatattacgc acaactaatg gtgacttttt gcatttctta cctagagttt ttagtgcagt 8940

tggtaacatc tgttacacac catcaaaact tatagagtac actgactttg caacatcagc 9000

ttgtgttttg gctgctgaat gtacaatttt taaagatgct tctggtaagc cagtaccata 9060

ttgttatgat accaatgtac tagaaggttc tgttgcttat gaaagtttac gccctgacac 9120

acgttatgtg ctcatggatg gctctattat tcaatttcct aacacctacc ttgaaggttc 9180

tgttagagtg gtaacaactt ttgattctga gtactgtagg cacggcactt gtgaaagatc 9240

agaagctggt gtttgtgtat ctactagtgg tagatgggta cttaacaatg attattacag 9300

atctttacca ggagttttct gtggtgtaga tgctgtaaat ttatttacta atatgtttac 9360

accactaatt caacctattg gtgctttgga catatcagca tctatagtag ctggtggtat 9420

tgtagctatc gtagtaacat gccttgccta ctattttatg aggtttagaa gagcttttgg 9480

tgaatacagt catgtagttg cctttaatac tttactattc cttatgtcat tcactgtact 9540

ctgtttaaca ccagtttact cattcttacc tggtgtttat tctgttattt acttgtactt 9600

gacattttat cttactaatg atgtttcttt tttagcacat attcagtgga tggttatgtt 9660

cacaccttta gtacctttct ggataacaat tgcttatatc atttgtattt ccacaaagca 9720

tttctattgg ttctttagta attacctaaa gagacgtgta gtctttaatg gtgtttcctt 9780

tagtactttt gaagaagctg cgctgtgcac ctttttgtta aataaagaaa tgtatctaaa 9840

gttgcgtagt gatgtgctat tacctcttac gcaatataat agatacttag ctctttataa 9900

taagtacaag tattttagtg gagcaatgga tacaactagc tacagagaag ctgcttgttg 9960

tcatctcgca aaggctctca atgacttcag taactcaggt tctgatgttc tttaccaacc 10020

accacaaacc tctatcacct cagctgtttt gcagagtggt tttagaaaaa tggcattccc 10080

atctggtaaa gttgagggtt gtatggtaca agtaacttgt ggtacaacta cacttaacgg 10140

tctttggctt gatgacgtag tttactgtcc aagacatgtg atctgcacct ctgaagacat 10200

gcttaaccct aattatgaag atttactcat tcgtaagtct aatcataatt tcttggtaca 10260

ggctggtaat gttcaactca gggttattgg acattctatg caaaattgtg tacttaagct 10320

tagggttgat acagccaatc ctaagacacc taagtataag tttgttcgca ttcaaccagg 10380

acagactttt tcagtgttag cttgttacaa tggttcacca tctggtgttt accaatgtgc 10440

tatgaggccc aatttcacta ttaagggttc attccttaat ggttcatgtg gtagtgttgg 10500

ttttaacata gattatgact gtgtctcttt ttkttacatg caccatatgg aattaccaac 10560

tggagttcat gctggcacag acttagaagg taacttttat ggaccttttg ttgacaggca 10620

aacagcacaa gcagctggta cggacacaac tattacagtt aatgttttag cttggttgta 10680

cgctgctgtt ataaatggag acaggtggtt tctcaatcga tttaccacaa ctcttaatga 10740

ctttaacctt gtggctatga agtacaatta tgaacytcta acacaagacc atgttgacat 10800

actaggacct ctttctgctc aaactggaat tgccgtttta gatatgtgtg cttcattaaa 10860

agaattactg caaaatggta tgaatggacg taccatattg ggtagtgctt tattagaaga 10920

tgaatttaca ccttttgatg ttgttagaca atgctcaggt gttactttcc aaagtgcagt 10980

gaaaagaaca atcaagggta cacaccactg gttgttactc acaattttga cttcactttt 11040

agttttagtc cagagtactc aatggtcttt gttctttttt ttgtatgaaa atgccttttt 11100

accttttgct atgggtatta ttgctatgtc tgcttttgca atgatgtttg tcaaacataa 11160

gcatgcattt ctctgtttgt ttttgttacc ttctcttgcc actgtagctt attttaatat 11220

ggtctatatg cctgctagtt gggtgatgcg tattatgaca tggttggata tggttgatac 11280

tagtttgnnn nnnaagctaa aagactgtgt tatgtatgca tcagctgtag tgttactaat 11340

ccttatgaca gcaagaactg tgtatgatga tggtgctagg agagtgtgga cacttatgaa 11400

tgtcttgaca ctcgtttata aagtttatta tggtaatgct ttagatcaag ccatttccat 11460

gtgggctctt ataatctctg ttacttctaa ctactcaggt gtagttacaa ctgtcatgtt 11520

tttggccaga ggtattgttt ttatgtgtgt tgagtattgc cctattttct tcataactgg 11580

taatacactt cagtgtataa tgctagttta ttgtttctta ggctattttt gtacttgtta 11640

ctttggcctc ttttgtttac tcaaccgcta ctttagactg actcttggtg tttatgatta 11700

cttagtttct acacaggagt ttagatatat gaattcacag ggactaytcc cacccaagaa 11760

tagcatagat gccttcaaac tcaacattaa attgttgggt gttggtggca aaccttgtat 11820

caaagtagcc actgtacagt ctaaaatgtc agatgtaaag tgcacatcag tagtcttact 11880

ctcagttttg caacaactca gagtagaatc atcatctaaa ttgtgggctc aatgtgtcca 11940

gttacacaat gacattctct tagctaaaga tactactgaa gcctttgaaa aaatggtttc 12000

actactttct gttttgcttt ccatgcaggg tgctgtagac ataaacaagc tttgtgaaga 12060

aatgctggac aacagggcaa ccttacaagc tatagcctca gagtttagtt cccttccatc 12120

atatgcagct tttgctactg ctcaagaagc ttatgagcag gctgttgcta atggtgattc 12180

tgaagttgtt cttaaaaagt tgaagaagtc tttgaatgtg gctaaatctg aatttgaccg 12240

tgatgcagcc atgcaacgta agttggaaaa gatggctgat caagctatga cccaaatgta 12300

taaacaggct agatctgagg acaagagggc aaaagttact agtgctatgc agacaatgct 12360

tttcactatg cttagaaagt tggataatga tgcactcaac aacattatca acaatgcaag 12420

agatggttgt gttcccttga acataatacc tcttacaaca gcagccaaac taatggttgt 12480

cataccagac tataacacat ataaaaatac gtgtgatggt acaacattta cttatgcatc 12540

agcattgtgg gaaatccaac aggttgtaga tgcagatagt aaaattgttc aacttagtga 12600

aattagtatg gacaattcac ctaatttagc atggcctctt attgtaacag ctttaagggc 12660

caattctgct gtcaaattac agaataatga gcttagtcct gttgcactac gacagatgtc 12720

ttgtgctgcc ggtactacac aaactgcttg cactgatgac aatgcgttag cttactacaa 12780

cacaacaaag ggaggtaggt ttgtacttgc actgttatcc gatttacagg atttgaaatg 12840

ggctagattc cctaagagtg atggaactgg tactatctat acagaactgg aaccaccttg 12900

taggtttgtt acagacacac ctaaaggtcc taaagtgaag tatttatact ttattaaagg 12960

attaaacaac ctaaatagag gtatggtact tggtagttta gctgccacag tacgtctaca 13020

agctggtaat gcaacagaag tgcctgccaa ttcaactgta ttatctttct gtgcttttgc 13080

tgtagatgct gctaaagctt acaaagatta tctagctagt gggggacaac caatcactaa 13140

ttgtgttaag atgttgtgta cacacactgg tactggtcag gcaataacag ttacaccgga 13200

agccaatatg gatcaagaat cctttggtgg tgcatcgtgt tgtctgtact gccgttgcca 13260

catagatcat ccaaatccta aaggattttg tgacttaaaa ggtaagtatg tacaaatacc 13320

tacaacttgt gctaatgacc ctgtgggttt tacacttaaa aacacagtct gtaccgtctg 13380

cggtatgtgg aaaggttatg gctgtagttg tgatcaactc cgcgaaccca tgcttcagtc 13440

agctgatgca caatcgtttt taaacgggtt tgcggtgtaa gtgcagcccg tcttacaccg 13500

tgcggcacag gcactagtac tgatgtcgta tacagggctt ttgacatcta caatgataaa 13560

gtagctggtt ttgctaaatt cctaaaaact aattgttgtc gcttccaaga aaaggacgaa 13620

gatgacaatt taattgattc ttactttgta gttaagagac acactttctc taactaccaa 13680

catgaagaaa caatttataa tttacttaag gattgtccag ctgttgctaa acatgacttc 13740

tttaagttta gaatagacgg tgacatggta ccacatatat cacgtcaacg tcttactaaa 13800

tacacaatgg cagacctcgt ctatgcttta aggcattttg atgaaggtaa ttgtgacaca 13860

ttaaaagaaa tacttgtcac atacaattgt tgtgatgatg attatttcaa taaaaaggac 13920

tggtatgatt ttgtagaaaa cccagatata ttacgcgtat acgccaactt aggtgaacgt 13980

gtacgccaag ctttgttaaa aacagtacaa ttctgtgatg ccatgcgaaa tgctggtatt 14040

gttggtgtac tgacattaga taatcaagat ctcaatggta actggtatga tttcggtgat 14100

ttcatacaaa ccacgccagg tagtggagtt cctgttgtag attcttatta ttcattgtta 14160

atgcctatat taaccttgac cagggcttta actgcagagt cacatgttga cactgactta 14220

acaaagcctt acattaagtg ggatttgtta aaatatgact tcacggaaga gaggttaaaa 14280

ctctttgacc gttattttaa atattgggat cagacatacc acccaaattg tgttaactgt 14340

ttggatgaca gatgcattct gcattgtgca aactttaatg ttttattctc tacagtgttc 14400

ccacttacaa gttttggacc actagtgaga aaaatatttg ttgatggtgt tccatttgta 14460

gtttcaactg gataccactt cagagagcta ggtgttgtac ataatcagga tgtaaactta 14520

catagctcta gacttagttt taaggaatta cttgtgtatg ctgctgaccc tgctatgcac 14580

gctgcttctg gtaatctatt actagataaa cgcactacgt gcttttcagt agctgcactt 14640

actaacaatg ttgcttttca aactgtcaaa cccggtaatt ttaacaaaga cttctatgac 14700

tttgctgtgt ctaagggttt ctttaaggaa ggaagttctg ttgaattaaa acacttcttc 14760

tttgctcagg atggtaatgc tgctatcagc gattatgact actatcgtta taatctacca 14820

acaatgtgtg atatcagaca actactattt gtagttgaag ttgttgataa gtactttgat 14880

tgttacgatg gtggctgtat taatgctaac caagtcatcg tcaacaacct agacaaatca 14940

gctggttttc catttaataa atggggtaag gctagacttt attatgattc aatgagttat 15000

gaggatcaag atgcactttt cgcatataca aaacgtaatg tcatccctac tataactcaa 15060

atgaatctta agtatgccat tagtgcaaag aatagagctc gcaccgtagc tggtgtctct 15120

atctgtagta ctatgaccaa tagacagttt catcaaaaat tattgaaatc aatagccgcc 15180

actagaggag ctactgtagt aattggaaca agcaaattct atggtggttg gcacaacatg 15240

ttaaaaactg tttatagtga tgtagaaaac cctcacctta tgggttggga ttatcctaaa 15300

tgtgatagag ccatgcctaa catgcttaga attatggcct cacttgttct tgctcgcaaa 15360

catacaacgt gttgtagctt gtcacaccgt ttctatagat tagctaatga gtgtgctcaa 15420

gtattgagtg aaatggtcat gtgtggcggt tcactatatg ttaaaccagg tggaacctca 15480

tcaggagatg ccacaactgc ttatgctaat agtgttttta acatttgtca agctgtcacg 15540

gccaatgtta atgcactttt atctactgat ggtaacaaaa ttgccgataa gtatgtccgc 15600

aatttacaac acagacttta tgagtgtctc tatagaaata gagatgttga cacagacttt 15660

gtgaatgagt tttacgcata tttgcgtaaa catttctcaa tgatgatact ctctgacgat 15720

gctgttgtgt gtttcaatag cacttatgca tctcaaggtc tagtggctag cataaagaac 15780

tttaagtcag ttctttatta tcaaaacaat gtttttatgt ctgaagcaaa atgttggact 15840

gagactgacc ttactaaagg acctcatgaa ttttgctctc aacatacaat gctagttaaa 15900

cagggtgatg attatgtgta ccttccttac ccagatccat caagaatcct aggggccggc 15960

tgttttgtag atgatatcgt aaaaacagat ggtacactta tgattgaacg gttcgtgtct 16020

ttagctatag atgcttaccc acttactaaa catcctaatc aggagtatgc tgatgtcttt 16080

catttgtact tacaatacat aagaaagcta catgatgagt taacaggaca catgttagac 16140

atgtattctg ttatgcttac taatgataac acttcaaggt attgggaacc tgagttttat 16200

gaggctatgt acacaccgca tacagtctta caggctgttg gggcttgtgt tctttgcaat 16260

tcacagactt cattaagatg tggtgcttgc atacgtagac cattcttatg ttgtaaatgc 16320

tgttacgacc atgtcatatc aacatcacat aaattagtct tgtctgttaa tccgtatgtt 16380

tgcaatgctt caggttgtga tgtcacagat gtgactcaac tttacttagg aggtatgagc 16440

tattattgta aatcacataa accacccatt agttttccat tgtgtgctaa tggacaagtt 16500

tttggtttat ataaaaatac atgtgttggt agcgataatg ttactgactt taatgcaatt 16560

gcaacatgtg actggacaaa tgctggtgat tacattttag ctaacacctg tactgaaaga 16620

ctcaagcttt ttgcagcaga aacgctcaaa gctactgagg agacatttaa actgtcttat 16680

ggtattgcta ctgtacgtga agtgctgtct gacagagaat tacatctttc atgggaagtt 16740

ggtaaaccta gaccaccact taaccgaaat tatgtcttta ctggttatcg tgtaactaaa 16800

aacagtaaag tacaaatagg agagtacacc tttgaaaaag gtgactatgg tgatgctgtt 16860

gtttaccgag gtacaacaac ttacaaatta aatgttggtg attattttgt gctgacatca 16920

catacagtaa tgccattaag tgcacctaca ctagtgccac aagagcacta tgttagaatt 16980

actggcttat acccaacact caatatctca gatgagtttt ctagcaatgt tgcaaattat 17040

caaaaggttg gtatgcaaaa gtattctaca ctccagggac cacctggtac tggtaagagt 17100

cattttgcta ttggcctagc tctctactac ccttctgctc gcatagtgta tacagcttgc 17160

tctcatgccg ctgttgatgc actatgtgag aaggcattaa aatatttgcc tatagataaa 17220

tgtagtagaa ttatacctgc acgtgctcgt gtagagtgtt ttgataaatt caaagtgaat 17280

tcaacattag aacagtatgt cttttgtact gtaaatgcat tgcctgagac gacagcagat 17340

atagttgtct ttgatgaaat ttcaatggcc acaaattatg atttgagtgt tgtcaatgcc 17400

agattacgtg ctaagcacta tgtgtacatt ggcgaccctg ctcaattacc tgcaccacgc 17460

acattgctaa ctaagggcac actagaacca gaatatttca attcagtgtg tagacttatg 17520

aaaactatag gtccagacat gttcctcgga acttgtcggc gttgtcctgc tgaaattgtt 17580

gacactgtga gtgctttggt ttatgataat aagcttaaag cacataaaga caaatcagct 17640

caatgcttta aaatgtttta taagggtgtt atcacgcatg atgtttcatc tgcaattaac 17700

aggccacaaa taggcgtggt aagagaattc cttacacgta accctgcttg gagaaaagct 17760

gtctttattt caccttataa ttcacagaat gctgtagcct caaagatttt gggactacca 17820

actcaaactg ttgattcatc acagggctca gaatatgact atgtcatatt cactcaaacc 17880

actgaaacag ctcactcttg taatgtaaac agatttaatg ttgctattac cagagcaaaa 17940

gtaggcatac tttgcataat gtctgataga gacctttatg acaagttgca atttacaagt 18000

cttgaaattc cacgtaggaa tgtggcaact ttacaagctg aaaatgtaac aggactcttt 18060

aaagattgta gtaaggtaat cactgggtta catcctacac aggcacctac acacctcagt 18120

gttgacacta aattcaaaac tgaaggttta tgtgttgaca tacctggcat acctaaggac 18180

atgacctata gaagactcat ctctatgatg ggttttaaaa tgaattatca agttaatggt 18240

taccctaaca tgtttatcac ccgcgaagaa gctataagac atgtacgtgc atggattggc 18300

ttcgatgtcg aggggtgtca tgctactaga gaagctgttg gtaccaattt acctttacag 18360

ctaggttttt ctacaggtgt taacctagtt gctgtaccta caggttatgt tgatacacct 18420

aataatacag atttttccag agttagtgct aaaccaccgc ctggagatca atttaaacac 18480

ctcataccac ttatgtacaa aggacttcct tggaatgtag tgcgtataaa gattgtacaa 18540

atgttaagtg acacacttaa aaatctctct gacagagtcg tatttgtctt atgggcacat 18600

ggctttgagt tgacatctat gaagtatttt gtgaaaatag gacctgagcg cacctgttgt 18660

ctatgtgata gacgtgccac atgcttttcc actgcttcag acacttatgc ctgttggcat 18720

cattctattg gatttgatta cgtctataat ccgtttatga ttgatgttca acaatggggt 18780

tttacaggta acctacaaag caaccatgat ctgtattgtc aagtccatgg taatgcacat 18840

gtagctagtt gtgatgcaat catgactagg tgtctagctg tccacgagtg ctttgttaag 18900

cgtgttgact ggactattga atatcctata attggtgatg aactgaagat taatgcggct 18960

tgtagaaagg ttcaacacat ggttgttaaa gctgcattat tagcagacaa attcccagtt 19020

cttcacgaca ttggtaaccc taaagctatt aagtgtgtac ctcaagctga tgtagaatgg 19080

aagttctatg atgcacagcc ttgtagtgac aaagcttata aaatagaaga attattctat 19140

tcttatgcca cacattctga caaattcaca gatggtgtat gcctattttg gaattgcaat 19200

gtcgatagat atcctgctaa ttccattgtt tgtagatttg acactagagt gctatctaac 19260

cttaacttgc ctggttgtga tggtggcagt ttgtatgtaa ataaacatgc attccacaca 19320

ccagcttttg ataaaagtgc ttttgttaat ttaaaacaat taccattttt ctattactct 19380

gacagtccat gtgagtctca tggaaaacaa gtagtgtcag atatagatta tgtaccacta 19440

aagtctgcta cgtgtataac acgttgcaat ttaggtggtg ctgtctgtag acatcatgct 19500

aatgagtaca gattgtatct cgatgcttat aacatgatga tctcagctgg ctttagcttg 19560

tgggtttaca aacaatttga tacttataac ctctggaaca cttttacaag acttcagagt 19620

ttagaaaatg tggcttttaa tgttgtaaat aagggacact ttgatggaca acagggtgaa 19680

gtaccagttt ctatcattaa taacactgtt tacacaaaag ttgatggtgt tgatgtagaa 19740

ttgtttgaaa ataaaacaac attacctgtt aatgtagcat ttgagctttg ggctaagcgc 19800

aacattaaac cagtaccaga ggtgaaaata ctcaataatt tgggtgtgga cattgctgct 19860

aatactgtga tctgggacta caaaagagat gctccagcac atatatctac tattggtgtt 19920

tgttctatga ctgacatagc caagaaacca actgaaacga tttgtgcacc actcactgtc 19980

ttttttgatg gtagagttga tggtcaagta gacttattta gaaatgcccg taatggtgtt 20040

cttattacag aaggtagtgt taaaggttta caaccatctg taggtcccaa acaagctagt 20100

cttaatggag tcacattaat tggagaagcc gtaaaaacac agttcaatta ttataagaaa 20160

gttgatggtg ttgtccaaca attacctgaa acttacttta ctcagagtag aaatttacaa 20220

gaatttaaac ccaggagtca aatggaaatt gatttcttag aattagctat ggatgaattc 20280

attgaacggt ataaattaga aggctatgcc ttcgaacata tcgtttatgg agattttagt 20340

catagtcagt taggtggttt acatctactg attggactag ctaaacgttt taaggaatca 20400

ccttttgaat tagaagattt tattcctatg gacagtacag ttaaaaacta tttcataaca 20460

gatgcgcaaa caggttcatc taagtgtgtg tgttctgtta ttgatttatt acttgatgat 20520

tttgttgaaa taataaaatc ccaagattta tctgtagttt ctaaggttgt caaagtgact 20580

attgactata cagaaatttc atttatgctt tggtgtaaag atggccatgt agaaacattt 20640

tacccaaaat tacaatctag tcaagcgtgg caaccgggtg ttgctatgcc taatctttac 20700

aaaatgcaaa gaatgctatt agaaaagtgt gaccttcaaa attatggtga tagtgcaaca 20760

ttacctaaag gcataatgat gaatgtcgca aaatatactc aactgtgtca atatttaaac 20820

acattaacat tagctgtacc ctataatatg agagttatac attttggtgc tggttctgat 20880

aaaggagttg caccaggtac agctgtttta agacagtggt tgcctacggg tacgctgctt 20940

gtcgattcag atcttaatga ctttgtctct gatgcagatt caactttgat tggtgattgt 21000

gcaactgtac atacagctaa taaatgggat ctcattatta gtgatatgta cgaccctaag 21060

actaaaaatg ttacaaaaga aaatgactct aaagagggtt ttttcactta catttgtggg 21120

tttatacaac aaaagctagc tcttggaggt tccgtggcta taaagataac agaacattct 21180

tggaatgctg atctttataa gctcatggga cacttcgcat ggtggacagc ctttgttact 21240

aatgtgaatg cgtcatcatc tgaagcattt ttaattggat gtaattatct tggcaaacca 21300

cgcgaacaaa tagatggtta tgtcatgcat gcaaattaca tattttggag gaatacaaat 21360

ccaattcagt tgtcttccta ttctttattt gacatgagta aatttcccct taaattaagg 21420

ggtactgctg ttatgtcttt aaaagaaggt caaatcaatg atatgatttt atctcttctt 21480

agtaaaggta gacttataat tagagaaaac aacagagttg ttatttctag tgatgttctt 21540

gttaacaact aaacgaacaa tgtttgtttt tcttgtttta ttgccactag tctctagtca 21600

gtgtgttaat cttacaacca gaactcaatt accccctgca tacactaatt ctttcacacg 21660

tggtgtttat taccctgaca aagttttcag atcctcagtt ttacattcaa ctcaggactt 21720

gttcttacct ttcttttcca atgttacttg gttccatgct atacatgtct ctgggaccaa 21780

tggtactaag aggtttgcta accctgtcct accatttaat gatggtgttt attttgcttc 21840

cactgagaag tctaacataa taagaggctg gatttttggt actactttag attcgaagac 21900

ccagtcccta cttattgtta ataacgctac taatgttgtt attaaagtct gtgaatttca 21960

attttgtaat gatccatttt tgggtgttta ttaccacaaa aacaacaaaa gttggatgga 22020

aagtgagttc agagtttatt ctagtgcgaa taattgcact tttgaatatg tctctcagcc 22080

ttttcttatg gaccttgaag gaaaacaggg taatttcaaa aatcttaggg aatttgtgtt 22140

taagaatatt gatggttatt ttaaaatata ttctaagcac acgcctatta atttagtgcg 22200

tggtctccct cagggttttt cggctttaga accattggta gatttgccaa taggtattaa 22260

catcactagg tttcaaannn nnnctttaca tagaagttat ttgactcctg gtgattcttc 22320

ttcaggttgg acagctggtg ctgcagctta ttatgtgggt tatcttcaac ctaggacttt 22380

tctattaaaa tataatgaaa atggaaccat tacagatgct gtagactgtg cacttgaccc 22440

tctctcagaa acaaagtgta cgttgaaatc cttcactgta gaaaaaggaa tctatcaaac 22500

ttctaacttt agagtccaac caacagaatc tattgttaga tttcctaata ttacaaactt 22560

gtgccctttt ggtgaagttt ttaacgccac cagatttgca tctgtttatg cttggaacag 22620

gaagagaatc agcaactgtg ttgctgatta ttctgtccta tataattccg catcattttc 22680

cacttttaag tgttatggag tgtctcctac taaattaaat gatctctgct ttactaatgt 22740

ctatgcagat tcatttgtaa ttagaggtga tgaagtcaga caaatcgctc cagggcaaac 22800

tggaaatatt gctgattata attataaatt accagatgat tttacaggct gcgttatagc 22860

ttggaattct aacaatcttg attctaaggt tggtggtaat tataattacc tgtatagatt 22920

gtttaggaag tctaatctca aaccttttga gagagatatt tcaactgaaa tctatcaggc 22980

cggtagcaca ccttgtaatg gtgttaaagg ttttaattgt tactttcctt tacaatcata 23040

tggtttccaa cccacttatg gtgttggtta ccaaccatac agagtagtag tactttcttt 23100

tgaacttcta catgcaccag caactgtttg tggacctaaa aagtctacta atttggttaa 23160

aaacaaatgt gtcaatttca acttcaatgg tttaacaggc acaggtgttc ttactgagtc 23220

taacaaaaag tttctgcctt tccaacaatt tggcagagac attgctgaca ctactgatgc 23280

tgtccgtgat ccacagacac ttgagattct tgacattaca ccatgttctt ttggtggtgt 23340

cagtgttata acaccaggaa caaatacttc taaccaggtt gctgttcttt atcagggtgt 23400

taactgcaca gaagtccctg ttgctattca tgcagatcaa cttactccta cttggcgtgt 23460

ttattctaca ggttctaatg tttttcaaac acgtgcaggc tgtttaatag gggctgaaca 23520

tgtcaacaac tcatatgagt gtgacatacc cattggtgca ggtatatgcg ctagttatca 23580

gactcagact aattctcctc ggcgggcacg tagtgtagct agtcaatcca tcattgccta 23640

cactatgtca cttggtgtag aaaattcagt tgcttactct aataactcta ttgccatacc 23700

cacaaatttt actattagtg ttaccacaga aattctacca gtgtctatga ccaagacatc 23760

agtagattgt acaatgtaca tttgtggtga ttcaactgaa tgcagcaatc ttttgttgca 23820

atatggcagt ttttgtacac aattaaaccg tgctttaact ggaatagctg ttgaacaaga 23880

caaaaacacc caagaagttt ttgcacaagt caaacaaatt tacaaaacac caccaattaa 23940

agattttggt ggttttaatt tttcacaaat attaccagat ccatcaaaac caagcaagag 24000

gtcatttatt gaagatctac ttttcaacaa agtgacactt gcagatgctg gcttcatcaa 24060

acaatatggt gattgccttg gtgatattgc tgctagagac ctcatttgtg cacaaaagtt 24120

taacggcctt actgttttgc cacctttgct cacagatgaa atgattgctc aatacacttc 24180

tgcactgtta gcgggtacaa tcacttctgg ttggaccttt ggtgcaggtg ctgcattaca 24240

aataccattt gctatgcaaa tggcttatag gtttaatggt attggagtta cacagaatgt 24300

tctctatgag aaccaaaaat tgattgccaa ccaatttaat agtgctattg gcaaaattca 24360

agactcactt tcttccacag caagtgcact tggaaaactt caagatgtgg tcaaccaaaa 24420

tgcacaagct ttaaacacgc ttgttaaaca acttagctcc aattttggtg caatttcaag 24480

tgttttaaat gatatccttt cacgtcttga caaagttgag gctgaagtgc aaattgatag 24540

gttgatcaca ggcagacttc aaagtttgca gacatatgtg actcaacaat taattagagc 24600

tgcagaaatc agagcttctg ctaatcttgc tgctactaaa atgtcagagt gtgtacttgg 24660

acaatcaaaa agagttgatt tttgtggaaa gggctatcat cttatgtcct tccctcagtc 24720

agcacctcat ggtgtagtct tcttgcatgt gacttatgtc cctgcacaag aaaagaactt 24780

cacaactgct cctgccattt gtcatgatgg aaaagcacac tttcctcgtg aaggtgtctt 24840

tgtttcaaat ggcacacact ggtttgtaac acaaaggaat ttttatgaac cacaaatcat 24900

tactacagac aacacatttg tgtctggtaa ctgtgatgtt gtaataggaa ttgtcaacaa 24960

cacagtttat gatcctttgc aacctgaatt agactcattc aaggaggagt tagataaata 25020

ttttaagaat catacatcac cagatgttga tttaggtgac atctctggca ttaatgcttc 25080

agttgtaaac attcaaaaag aaattgaccg cctcaatgag gttgccaaga atttaaatga 25140

atctctcatc gatctccaag aacttggaaa gtatgagcag tatataaaat ggccatggta 25200

catttggcta ggttttatag ctggcttgat tgccatagta atggtgacaa ttatgctttg 25260

ctgtatgacc agttgctgta gttgtctcaa gggctgttgt tcttgtggat cctgctgcaa 25320

atttgatgaa gacgactctg agccagtgct caaaggagtc aaattacatt acacataaac 25380

gaacttatgg atttgtttat gagaatcttc acaattggaa ctgtaacttt gaagcaaggt 25440

gaaatcaagg atgctactcc ttcagatttt gttcgcgcta ctgcaacgat accgatacaa 25500

gcctcactcc ctttcggatg gcttattgtt ggcgttgcac ttcttgctgt ttttcatagc 25560

gcttccaaaa tcataaccct caaaaagaga tggcaactag cactctccaa gggtgttcac 25620

tttgtttgca acttgctgtt gttgtttgta acagtttact cacacctttt gctcgttgct 25680

gctggccttg aagccccttt tctctatctt tatgctttag tctacttctt gcagagtata 25740

aactttgtaa gaataataat gaggctttgg ctttgctgga aatgccgttc caaaaaccca 25800

ttactttatg atgccaacta ttttctttgc tggcatacta attgttacga ctattgtata 25860

ccttacaata gtgtaacttc ttcaattgtc attactttag gtgatggcac aacaagtcct 25920

atttctgaac atgactacca gattggtggt tatactgaaa aatgggaatc tggagtaaaa 25980

gactgtgttg tattacacag ttacttcact tcagactatt accagctgta ctcaactcaa 26040

ttgagtacag acactggtgt tgaacatgtt accttcttca tctacaataa aattgttgat 26100

gagcctgaag aacatgtcca aattcacaca atcgacggtt catccggagt tgttaatcca 26160

gtaatggaac caatttatga tgaaccgacg acgactacta gcgtgccttt gtaagcacaa 26220

gctgatgagt acgaacttat gtactcattc gtttcggaag agacaggtac gttaatagtt 26280

aatagcgtac ttctttttct tgctttcgtg gtattcttgc tagttacact agccatcctt 26340

actgcgcttc gattgtgtgc gtactgctgc aatattgtta acgtgagtct tgtaaaacct 26400

tctttttacg tttactctcg tgttaaaaat ctgaattctt ctagagttct tgatcttctg 26460

gtctaaacga actaaatatt atattagttt ttctgtttgg aactttaatt ttagccatgg 26520

cagattccaa cggtactatt accgttgaag agcttaaaaa gctccttgaa caatggaacc 26580

tagtaatagg tttcctattc cttacatgga tttgtcttct acaatttgcc tatgccaaca 26640

ggaataggtt tttgtatata attaagttaa ttttcctctg gctgttatgg ccagtaactt 26700

tagcttgttt tgtgcttgct gctgtttaca gaataaattg gatcaccggt ggaattgcta 26760

tcgcaatggc ttgtcttgta ggcttgatgt ggctcagcta cttcattgct tctttcagac 26820

tgtttgcgcg tacgcgttcc atgtggtcat tcaatccaga aactaacatt cttctcaacg 26880

tgccactcca tggcactatt ctgaccagac cgcttctaga aagtgaactc gtaatcggag 26940

ctgtgatcct tcgtggacat cttcgtattg ctggacacca tctaggacgc tgtgacatca 27000

aggacctgcc taaagaaatc actgttgcta catcacgaac gctttcttat tacaaattgg 27060

gagcttcgca gcgtgtagca ggtgactcag gttttgctgc atacagtcgc tacaggattg 27120

gcaactataa attaaacaca gaccattcca gtagcagtga caatattgct ttgcttgtac 27180

agtaagcgac aacagatgtt tcatctcgtt gactttcagg ttactatagc agagatatta 27240

ctaattatta tgaggacttt taaagtttcc atttggaatc ttgattacat cataaacctc 27300

ataattaaaa atttatctaa gtcactaact gagaataaat attctcaatt agatgaagag 27360

caaccaatgg agattgatta aacgaacatg aaaattattc ttttcttggc actgataaca 27420

ctcgctactt gtgagcttta tcactaccaa gagtgtgtta gaggtacaac agtactttta 27480

aaagaacctt gctcttctgg aacatacgag ggcaattcac catttcatcc tctagctgat 27540

aacaaatttg cactgacttg ctttagcact caatttgctt ttgcttgtcc tgacggcgta 27600

aaacacgtct atcagttacg tgccagatca gtttcaccta aactgttcat cagacaagag 27660

gaagttcaag aactttactc tccaattttt cttattgttg cggcaatagt gtttataaca 27720

ctttgcttca cactcaaaag aaagacagaa tgattgaact ttcattaatt gacttctatt 27780

tgtgcttttt agcctttctg ctattccttg ttttaattat gcttattatc ttttggttct 27840

cacttgaact gcaagatcat aatgaaactt gtcacgccta aacgaacatg aaatttcttg 27900

ttttcttagg aatcatcaca actgtagctg catttcacca agaatgtagt ttacagtcat 27960

gtactcaaca tcaaccatat gtagttgatg acccgtgtcc tattcacttc tattctaaat 28020

ggtatattag agtaggagct agaaaatcag cacctttaat tgaattgtgc gtggatgagg 28080

ctggttctaa atcacccatt cagtacatcg atatcggtaa ttatacagtt tcctgtttac 28140

cttttacaat taattgccag gaacctaaat tgggtagtct tgtagtgcgt tgttcgttct 28200

atgaagactt tttagagtat catgacgttc gtgttgtttt agattttatc taaacgaaca 28260

aactaaaatg tctgataatg gaccccaaaa tcagcgaaat gcaccccgca ttacgtttgg 28320

tggaccctca gattcaactg gcagtaacca gaatggagaa cgcagtgggg cgcgatcaaa 28380

acaacgtcgg ccccaaggtt tacccaataa tactgcgtct tggttcaccg ctctcactca 28440

acatggcaag gaagacctta aattccctcg aggacaaggc gttccaatta acaccaatag 28500

cagtccagat gaccaaattg gctactaccg aagagctacc agacgaattc gtggtggtga 28560

cggtaaaatg aaagatctca gtccaagatg gtatttctac tacctaggaa ctgggccaga 28620

agctggactt ccctatggtg ctaacaaaga cggcatcata tgggttgcaa ctgagggagc 28680

cttgaataca ccaaaagatc acattggcac ccgcaatcct gctaacaatg ctgcaatcgt 28740

gctacaactt cctcaaggaa caacattgcc aaaaggcttc tacgcagaag ggagcagagg 28800

cggcagtcaa gcctcttctc gttcctcatc acgtagtcgc aacagttcaa gaaattcaac 28860

tccaggcagc agtaggggaa tttctcctgc tagaatggct ggcaatggcg gtgatgctgc 28920

tcttgctttg ctgctgcttg acagattgaa ccagcttgag agcaaaatgt ctggtaaagg 28980

ccaacaacaa caaggccaaa ctgtcactaa gaaatctgct gctgaggctt ctaagaagcc 29040

tcggcaaaaa cgtactgcca ctaaagcata caatgtaaca caagctttcg gcagacgtgg 29100

tccagaacaa acccaaggaa attttgggga ccaggaacta atcagacaag gaactgatta 29160

caaacattgg ccgcaaattg cacaatttgc ccccagcgct tcagcgttct tcggaatgtc 29220

gcgcattggc atggaagtca caccttcggg aacgtggttg acctacacag gtgccatcaa 29280

attggatgac aaagatccaa atttcaaaga tcaagtcatt ttgctgaata agcatattga 29340

cgcatacaaa acattcccac caacagagcc taaaaaggac aaaaagaaga aggctgatga 29400

aactcaagcc ttaccgcaga gacagaagaa acagcaaact gtgactcttc ttcctgctgc 29460

agatttggat gatttctcca aacaattgca acaatccatg agcagtgctg actcaactca 29520

ggcctaaact catgcagacc acacaaggca gatgggctat ataaacgttt tcgcttttcc 29580

gtttacgata tatagtctac tcttgtgcag aatgaattct cgtaactaca tagcacaagt 29640

agatgtagtt aactttaatc tcacatagca atctttaatc agtgtgtaac attagggagg 29700

acttgaaaga gccaccacat tttcaccgag gccacgcgga gtacgatcga gtgtacagtg 29760

aacaatgcta gggagagctg cctatatgga agagccctaa tgtgtaaaat taattttagt 29820

agtgctatcc ccatgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnaaaaaa aaaaaaaaaa 29880

aaaaaaaaaa aaaaaaa 29897

<210> 19

<211> 1272

<212> PRT

<213> SARS-CoV2

<220>

<221> UNSURE

<222> (240)..(242)

<223> Xaa can be any naturally occurring amino acid (Xaa can and naturally curing amino acid)

<400> 19

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val

1 5 10 15

Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe

20 25 30

Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu

35 40 45

His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp

50 55 60

Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala

65 70 75 80

Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu

85 90 95

Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser

100 105 110

Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile

115 120 125

Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr

130 135 140

Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr

145 150 155 160

Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu

165 170 175

Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe

180 185 190

Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr

195 200 205

Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu

210 215 220

Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Xaa

225 230 235 240

Xaa Xaa Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly

245 250 255

Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg

260 265 270

Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val

275 280 285

Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser

290 295 300

Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln

305 310 315 320

Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro

325 330 335

Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp

340 345 350

Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr

355 360 365

Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr

370 375 380

Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val

385 390 395 400

Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn

405 410 415

Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val

420 425 430

Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr

435 440 445

Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu

450 455 460

Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn

465 470 475 480

Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe

485 490 495

Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu

500 505 510

Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys

515 520 525

Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly

530 535 540

Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro

545 550 555 560

Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg

565 570 575

Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly

580 585 590

Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala

595 600 605

Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His

610 615 620

Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn

625 630 635 640

Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn

645 650 655

Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser

660 665 670

Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser

675 680 685

Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val

690 695 700

Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser

705 710 715 720

Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp

725 730 735

Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu

740 745 750

Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly

755 760 765

Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val

770 775 780

Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn

785 790 795 800

Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe

805 810 815

Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe

820 825 830

Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu

835 840 845

Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu

850 855 860

Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr

865 870 875 880

Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro

885 890 895

Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln

900 905 910

Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser

915 920 925

Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu

930 935 940

Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr

945 950 955 960

Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu

965 970 975

Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile

980 985 990

Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr

995 1000 1005

Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu

1010 1015 1020

Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg

1025 1030 1035

Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln

1040 1045 1050

Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro

1055 1060 1065

Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp

1070 1075 1080

Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly

1085 1090 1095

Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile

1100 1105 1110

Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val

1115 1120 1125

Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu

1130 1135 1140

Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His

1145 1150 1155

Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn Ala

1160 1165 1170

Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu Val

1175 1180 1185

Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu Gly

1190 1195 1200

Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu Gly

1205 1210 1215

Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met Leu

1220 1225 1230

Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys Ser

1235 1240 1245

Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val

1250 1255 1260

Leu Lys Gly Val Lys Leu His Tyr Thr

1265 1270

<210> 20

<211> 29819

<212> DNA

<213> SARS-CoV2

<400> 20

caactttcga tctcttgtag atctgttctc taaacgaact ttaaaatctg tgtggctgtc 60

actcggctgc atgcttagtg cactcacgca gtataattaa taactaatta ctgtcgttga 120

caggacacga gtaactcgtc tatcttctgc aggctgctta cggtttcgtc cgtgttgcag 180

ccgatcatca gcacatctag gttttgtccg ggtgtgaccg aaaggtaaga tggagagcct 240

tgtccctggt ttcaacgaga aaacacacgt ccaactcagt ttgcctgttt tacaggttcg 300

cgacgtgctc gtacgtggct ttggagactc cgtggaggag gtcttatcag aggcacgtca 360

acatcttaaa gatggcactt gtggcttagt agaagttgaa aaaggcgttt tgcctcaact 420

tgaacagccc tatgtgttca tcaaacgttc ggatgctcga actgcacctc atggtcatgt 480

tatggttgag ctggtagcag aactcgaagg cattcagtac ggtcgtagtg gtgagacact 540

tggtgtcctt gtccctcatg tgggcgaaat accagtggct taccgcaagg ttcttcttcg 600

taagaacggt aataaaggag ctggtggcca tagttacggc gccgatctaa agtcatttga 660

cttaggcgac gagcttggca ctgatcctta tgaagacttt caagaaaact ggaacactaa 720

acatagcagt ggtgttaccc gtgaactcat gcgtgagctt aacggagggg catacactcg 780

ctatgtcgat aacaacttct gtggccctga tggctaccct cttgagtgca ttaaagacct 840

tctagcacgt gctggtaaag cttcatgcac tttgtccgaa caactggact ttattgacac 900

taagaggggt gtatactgct gccgtgaaca tgagcatgaa attgcttggt acacggaacg 960

ttctgaaaag agctatgaat tgcagacacc ttttgaaatt aaattggcaa agaaatttga 1020

caccttcaat ggggaatgtc caaattttgt atttccctta aattccataa tcaagactat 1080

tcaaccaagg gttgaaaaga aaaagcttga tggctttatg ggtagaattc gatctgtcta 1140

tccagttgcg tcaccaaatg aatgcaacca aatgtgcctt tcaactctca tgaagtgtga 1200

tcattgtggt gaaacttcat ggcagacggg cgattttgtt aaagccactt gcgaattttg 1260

tggcactgag aatttgacta aagaaggtgc cactacttgt ggttacttac cccaaaatgc 1320

tgttgttaaa atttattgtc cagcatgtca caattcagaa gtaggacctg agcatagtct 1380

tgccgaatac cataatgaat ctggcttgaa aaccattctt cgtaagggtg gtcgcactat 1440

tgcctttgga ggctgtgtgt tctcttatgt tggttgccat aacaagtgtg cctattgggt 1500

tccacgtgct agcgctaaca taggttgtaa ccatacaggt gttgttggag aaggttccga 1560

aggtcttaat gacaaccttc ttgaaatact ccaaaaagag aaagtcaaca tcaatattgt 1620

tggtgacttt aaacttaatg aagagatcgc cattattttg gcatcttttt ctgcttccac 1680

aagtgctttt gtggaaactg tgaaaggttt ggattataaa gcattcaaac aaattgttga 1740

atcctgtggt aattttaaag ttacaaaagg aaaagctaaa aaaggtgcct ggaatattgg 1800

tgaacagaaa tcaatactga gtcctcttta tgcatttgca tcagaggctg ctcgtgttgt 1860

acgatcaatt ttctcccgca ctcttgaaac tgctcaaaat tctgtgcgtg ttttacagaa 1920

ggccgctata acaatactag atggaatttc acagtattca ctgagactca ttgatgctat 1980

gatgttcaca tctgatttgg ctactaacaa tctagttgta atggcctaca ttacaggtgg 2040

tgttgttcag ttgacttcgc agtggctaac taacatcttt ggcactgttt atgaaaaact 2100

caaacccgtc cttgattggc ttgaagagaa gtttaaggaa ggtgtagagt ttcttagaga 2160

cggttgggaa attgttaaat ttatctcaac ctgtgcttgt gaaattgtcg gtggacaaat 2220

tgtcacctgt gcaaaggaaa ttaaggagag tgttcagaca ttctttaagc ttgtaaataa 2280

atttttggct ttgtgtgctg actctatcat tattggtgga gctaaactta aagccttgaa 2340

tttaggtgaa acatttgtca cgcactcaaa gggattgtac agaaagtgtg ttaaatccag 2400

agaagaaact ggcctactca tgcctctaaa agccccaaaa gaaattatct tcttagaggg 2460

agaaacactt cccacagaag tgttaacaga ggaagttgtc ttgaaaactg gtgatttaca 2520

accattagaa caacctacta gtgaagctgt tgaagctcca ttggttggta caccagtttg 2580

tattaacggg cttatgttgc tcgaaatcaa agacacagaa aagtactgtg cccttgcacc 2640

taatatgatg gtaacaaaca ataccttcac actcaaaggc ggtgcaccaa caaaggttac 2700

ttttggtgat gatactgtga tagaagtgca aggttacaag agtgtgaata tcacttttga 2760

acttgatgaa aggattgata aagtacttaa tgagaagtgc tctgcctata cagttgaact 2820

cggtacagaa gtaaatgagt tcgcctgtgt tgtggcagat gctgtcataa aaactttgca 2880

accagtatct gaattactta caccactggg cattgattta gatgagtgga gtatggctac 2940

atactactta tttgatgagt ctggtgagtt taaattggct tcacatatgt attgttcttt 3000

ttaccctcca gatgaggatg aagaagaagg tgattgtgaa gaagaagagt ttgagccatc 3060

aactcaatat gagtatggta ctgaagatga ttaccaaggt aaacctttgg aatttggtgc 3120

cacttctgct gctcttcaac ctgaagaaga gcaagaagaa gattggttag atgatgatag 3180

tcaacaaact gttggtcaac aagacggcag tgaggacaat cagacaacta ctattcaaac 3240

aattgttgag gttcaacctc aattagagat ggaacttaca ccagttgttc agactattga 3300

agtgaatagt tttagtggtt atttaaaact tactgacaat gtatacatta aaaatgcaga 3360

cattgtggaa gaagctaaaa aggtaaaacc aacagtggtt gttaatgcag ccaatgttta 3420

ccttaaacat ggaggaggtg ttgcaggagc cttaaataag gctactaaca atgccatgca 3480

agttgaatct gatgattaca tagctactaa tggaccactt aaagtgggtg gtagttgtgt 3540

tttaagcgga cacaatcttg ctaaacactg tcttcatgtt gtcggcccaa atgttaacaa 3600

aggtgaagac attcaacttc ttaagagtgc ttatgaaaat tttaatcagc acgaagttct 3660

acttgcacca ttattatcag ctggtatttt tggtgctgac cctatacatt ctttaagagt 3720

ttgtgtagat actgttcgca caaatgtcta cttagctgtc tttgataaaa atctctatga 3780

caaacttgtt ttaagctttt tggaaatgaa gagtgaaaag caagttgaac aaaagatcgc 3840

tgagattcct aaagaggaag ttaagccatt tataactgaa agtaaacctt cagttgaaca 3900

gagaaaacaa gatgataaga aaatcaaagc ttgtgttgaa gaagttacaa caactctgga 3960

agaaactaag ttcctcacag aaaacttgtt actttatatt gacattaatg gcaatcttca 4020

tccagattct gccactcttg ttagtgacat tgacatcact ttcttaaaga aagatgctcc 4080

atatatagtg ggtgatgttg ttcaagaggg tgttttaact gctgtggtta tacctactaa 4140

aaaggctggt ggcactactg aaatgctagc gaaagctttg agaaaagtgc caacagacaa 4200

ttatataacc acttacccgg gtcagggttt aaatggttac actgtagagg aggcaaagac 4260

agtgcttaaa aagtgtaaaa gtgcctttta cattctacca tctattatct ctaatgagaa 4320

gcaagaaatt cttggaactg tttcttggaa tttgcgagaa atgcttgcac atgcagaaga 4380

aacacgcaaa ttaatgcctg tctgtgtgga aactaaagcc atagtttcaa ctatacagcg 4440

taaatataag ggtattaaaa tacaagaggg tgtggttgat tatggtgcta gattttactt 4500

ttacaccagt aaaacaactg tagcgtcact tatcaacaca cttaacgatc taaatgaaac 4560

tcttgttaca atgccacttg gctatgtaac acatggctta aatttggaag aagctgctcg 4620

gtatatgaga tctctcaaag tgccagctac agtttctgtt tcttcacctg atgctgttac 4680

agcgtataat ggttatctta cttcttcttc taaaacacct gaagaacatt ttattgaaac 4740

catctcactt gctggttcct ataaagattg gtcctattct ggacaatcta cacaactagg 4800

tatagaattt cttaagagag gtgataaaag tgtatattac actagtaatc ctaccacatt 4860

ccacctagat ggtgaagtta tcacctttga caatcttaag acacttcttt ctttgagaga 4920

agtgaggact attaaggtgt ttacaacagt agacaacatt aacctccaca cgcaagttgt 4980

ggacatgtca atgacatatg gacaacagtt tggtccaact tatttggatg gagctgatgt 5040

tactaaaata aaacctcata attcacatga aggtaaaaca ttttatgttt tacctaatga 5100

tgacactcta cgtgttgagg cttttgagta ctaccacaca actgatccta gttttctggg 5160

taggtacatg tcagcattaa atcacactaa aaagtggaaa tacccacaag ttaatggttt 5220

aacttctatt aaatgggcag ataacaactg ttatcttgcc actgcattgt taacactcca 5280

acaaatagag ttgaagttta atccacctgc tctacaagat gcttattaca gagcaagggc 5340

tggtgaagct gctaactttt gtgcacttat cttagcctac tgtaataaga cagtaggtga 5400

gttaggtgat gttagagaaa caatgagtta cttgtttcaa catgccaatt tagattcttg 5460

caaaagagtc ttgaacgtgg tgtgtaaaac ttgtggacaa cagcagacaa cccttaaggg 5520

tgtagaagct gttatgtaca tgggcacact ttcttatgaa caatttaaga aaggtgttca 5580

gataccttgt acgtgtggta aacaagctac acaatatcta gtacaacagg agtcaccttt 5640

tgttatgatg tcagcaccac ctgctcagta tgaacttaag catggtacat ttacttgtgc 5700

tagtgagtac actggtaatt accagtgtgg tcactataaa catataactt ctaaagaaac 5760

tttgtattgc atagacggtg ctttacttac aaagtcctca gaatacaaag gtcctattac 5820

ggatgttttc tacaaagaaa acagttacac aacaaccata aaaccagtta cttataaatt 5880

ggatggtgtt gtttgtacag aaattgaccc taagttggac aattattata agaaagacaa 5940

ttcttatttc acagagcaac caattgatct tgtaccaaac caaccatatc caaacgcaag 6000

cttcgataat tttaagtttg tatgtgataa tatcaaattt gctgatgatt taaaccagtt 6060

aactggttat aagaaacctg cttcaagaga gcttaaagtt acatttttcc ctgacttaaa 6120

tggtgatgtg gtggctattg attataaaca ctacacaccc tcttttaaga aaggagctaa 6180

attgttacat aaacctattg tttggcatgt taacaatgca actaataaag ccacgtataa 6240

accaaatacc tggtgtatac gttgtctttg gagcacaaaa ccggttgaaa catcaaattc 6300

gtttgatgta ctgaagtcag aggacgcgca gggaatggat aatcttgcct gcgaagatct 6360

aaaaccagtc tctgaagaag tagtggaaaa tcctaccata cagaaagacg ttcttgagtg 6420

taatgtgaaa actaccgaag ttgtaggaga cattatactt aaaccagcaa ataatagttt 6480

aaaaattaca gaagaggttg gccacacaga tctaatggct gcttatgtag acaattctag 6540

tcttactatt aagaaaccta atgaattatc tagagtgtta ggtttgaaaa cccttgctac 6600

tcatggttta gctgctgtta atagtgtccc ttgggatact atagctaatt atgctaagcc 6660

ttttcttaac aaagttgtta gtacaactac taacatagtt acacggtgtt taaaccgtgt 6720

ttgtactaat tatatgcctt atttctttac tttattgcta caattgtgta cttttactag 6780

aagtacaaat tctagaatta aagcatctat gccgactact atagcaaaga atactgttaa 6840

gagtgtcggt aaattttgtc tagaggcttc atttaattat ttgaagtcac ctaatttttc 6900

taaactgata aatattataa tttggttttt actattaagt gtttgcctag gttctttaat 6960

ctactcaacc gctgctttag gtgttttaat gtctaattta ggcatgcctt cttactgtac 7020

tggttacaga gaaggctatt tgaactctac taatgtcact attgcaacct actgtactgg 7080

ttctatacct tgtagtgttt gtcttagtgg tttagattct ttagacacct atccttcttt 7140

agaaactata caaattacca tttcatcttt taaatgggat ttaactgctt ttggcttagt 7200

tgcagagtgg tttttggcat atattctttt cactaggttt ttctatgtac ttggattggc 7260

tgcaatcatg caattgtttt tcagctattt tgcagtacat tttattagta attcttggct 7320

tatgtggtta ataattaatc ttgtacaaat ggccccgatt tcagctatgg ttagaatgta 7380

catcttcttt gcatcatttt attatgtatg gaaaagttat gtgcatgttg tagacggttg 7440

taattcatca acttgtatga tgtgttacaa acgtaataga gcaacaagag tcgaatgtac 7500

aactattgtt aatggtgtta gaaggtcctt ttatgtctat gctaatggag gtaaaggctt 7560

ttgcaaacta cacaattgga attgtgttaa ttgtgataca ttctgtgctg gtagtacatt 7620

tattagtgat gaagttgcga gagacttgtc actacagttt aaaagaccaa taaatcctac 7680

tgaccagtct tcttacatcg ttgatagtgt tacagtgaag aatggttcca tccatcttta 7740

ctttgataaa gctggtcaaa agacttatga aagacattct ctctctcatt ttgttaactt 7800

agacaacctg agagctaata acactaaagg ttcattgcct attaatgtta tagtttttga 7860

tggtaaatca aaatgtgaag aatcatctgc aaaatcagcg tctgtttact acagtcagct 7920

tatgtgtcaa cctatactgt tactagatca ggcattagtg tctgatgttg gtgatagtgc 7980

ggaagttgca gttaaaatgt ttgatgctta cgttaatacg ttttcatcaa cttttaacgt 8040

accaatggaa aaactcaaaa cactagttgc aactgcagaa gctgaacttg caaagaatgt 8100

gtccttagac aatgtcttat ctacttttat ttcagcagct cggcaagggt ttgttgattc 8160

agatgtagaa actaaagatg ttgttgaatg tcttaaattg tcacatcaat ctgacataga 8220

agttactggc gatagttgta ataactatat gctcacctat aacaaagttg aaaacatgac 8280

accccgtgac cttggtgctt gtattgactg tagtgcgcgt catattaatg cgcaggtagc 8340

aaaaagtcac aacattgctt tgatatggaa cgttaaagat ttcatgtcat tgtctgaaca 8400

actacgaaaa caaatacgta gtgctgctaa aaagaataac ttacctttta agttgacatg 8460

tgcaactact agacaagttg ttaatgttgt aacaacaaag atagcactta agggtggtaa 8520

aattgttaat aattggttga agcagttaat taaagttaca cttgtgttcc tttttgttgc 8580

tgctattttc tatttaataa cacctgttca tgtcatgtct aaacatactg acttttcaag 8640

tgaaatcata ggatacaagg ctattgatgg tggtgtcact cgtgacatag catctacaga 8700

tacttgtttt gctaacaaac atgctgattt tgacacatgg tttagccagc gtggtggtag 8760

ttatactaat gacaaagctt gcccattgat tgctgcagtc ataacaagag aagtgggttt 8820

tgtcgtgcct ggtttgcctg gcacgatatt acgcacaact aatggtgact ttttgcattt 8880

cttacctaga gtttttagtg cagttggtaa catctgttac acaccatcaa aacttataga 8940

gtacactgac tttgcaacat cagcttgtgt tttggctgct gaatgtacaa tttttaaaga 9000

tgcttctggt aagccagtac catattgtta tgataccaat gtactagaag gttctgttgc 9060

ttatgaaaat ttacgccctg acacacgtta tgtgctcatg gatggctcta ttattcaatt 9120

tcctaacacc taccttgaag gttctgttag agtggtaaca acttttgatt ctgagtactg 9180

taggcacggc acttgtgaaa gatcagaagc tggtgtttgt gtatctacta gtggtagatg 9240

ggtacttaac aatgattatt acagatcttt accaggagtt ttctgtggtg tagatgctgt 9300

aaatttactt actaatatgt ttacaccact aattcaacct attggtgctt tggacatatc 9360

agcatctata gtagctggtg gtattgtagc tatcgtagta acatgccttg cctactattt 9420

tatgaggttt agaagagctt ttggtgaata cagtcatgta gttgccttta atactttact 9480

attccttatg tcattcactg tactctgttt aacaccagtt tactcattct tacctggtgt 9540

ttattctgtt atttacttgt acttgacatt ttatcttact aatgatgttt cttttttagc 9600

acatattcag tggatggtta tgttcacacc tttagtacct ttctggataa caattgctta 9660

tatcatttgt atttccacaa agcatttcta ttggttcttt agtaattacc taaagagacg 9720

tgtagtcttt aatggtgttt cctttagtac ttttgaagaa gctgcgctgt gcaccttttt 9780

gttaaataaa gaaatgtatc taaagttgcg tagtgatgtg ctattacctc ttacgcaata 9840

taatagatac ttagctcttt ataataagta caagtatttt agtggagcaa tggatacaac 9900

tagctacaga gaagctgctt gttgtcatct cgcaaaggct ctcaatgact tcagtaactc 9960

aggttctgat gttctttacc aaccaccaca aacctctatc acctcagctg ttttgcagag 10020

tggttttaga aaaatggcat tcccatctgg taaagttgag ggttgtatgg tacaagtaac 10080

ttgtggtaca actacactta acggtctttg gcttgatgac gtagtttact gtccaagaca 10140

tgtgatctgc acctctgaag acatgcttaa ccctaattat gaagatttac tcattcgtaa 10200

gtctaatcat aatttcttgg tacaggctgg taatgttcaa ctcagggtta ttggacattc 10260

tatgcaaaat tgtgtactta agcttaaggt tgatacagcc aatcctaaga cacctaagta 10320

taagtttgtt cgcattcaac caggacagac tttttcagtg ttagcttgtt acaatggttc 10380

accatctggt gtttaccaat gtgctatgag gcccaatttc actattaagg gttcattcct 10440

taatggttca tgtggtagtg ttggttttaa catagattat gactgtgtct ctttttgtta 10500

catgcaccat atggaattac caactggagt tcatgctggc acagacttag aaggtaactt 10560

ttatggacct tttgttgaca ggcaaacagc acaagcagct ggtacggaca caactattac 10620

agttaatgtt ttagcttggt tgtacgctgc tgttataaat ggagacaggt ggtttctcaa 10680

tcgatttacc acaactctta atgactttaa ccttgtggct atgaagtaca attatgaacc 10740

tctaacacaa gaccatgttg acatactagg acctctttct gctcaaactg gaattgtcgt 10800

tttagatatg tgtgcttcat taaaagaatt actgcaaaat ggtatgaatg gacgtaccat 10860

attgggtagt gctttattag aagatgaatt tacacctttt gatgttgtta gacaatgctc 10920

aggtgttact ttccaaagtg cagtgaaaag aacaatcaag ggtacacacc actggttgtt 10980

actcacaatt ttgacttcac ttttagtttt agtccagagt actcaatggt ctttgttctt 11040

ttttttgtat gaaaatgcct ttttaccttt tgctatgggt attattgcta tgtctgcttt 11100

tgcaatgatg tttgtcaaac ataagcatgc atttctctgt ttgtttttgt taccttctct 11160

tgccactgta gcttatttta atatggtcta tatgcctgct agttgggtga tgcgtattat 11220

gacatggttg gatatggttg atactagttt gaagctaaaa gactgtgtta tgtatgcatc 11280

agctgtagtg ttactaatcc ttatgacagc aagaactgtg tatgatgatg gtgctaggag 11340

agtgtggaca cttatgaatg tcttgacact cgtttataaa gtttattatg gtaatgcttt 11400

agatcaagcc atttccatgt gggctcttat aatctctgtt acttctaact actcaggtgt 11460

agttacaact gtcatgtttt tggccagagg tattgttttt atgtgtgttg agtattgccc 11520

tattttcttc ataactggta atacacttca gtgtataatg ctagtttatt gtttcttagg 11580

ctatttttgt acttgttact ttggcctctt ttgtttactc aaccgctact ttagactgac 11640

tcttggtgtt tatgattact tagtttctac acaggagttt agatatatga attcacaggg 11700

actactccca cccaagaata gcatagatgc cttcaaactc aacattaaat tgttgggtgt 11760

tggtggcaaa ccttgtatca aagtagccac tgtacagtct aaaatgtcag atgtaaagtg 11820

cacatcagta gtcttactct cagttttgca acaactcaga gtagaatcat catctaaatt 11880

gtgggctcaa tgtgtccagt tacacaatga cattctctta gctaaagata ctactgaagc 11940

ctttgaaaaa atggtttcac tactttctgt tttgctttcc atgcagggtg ctgtagacat 12000

aaacaagctt tgtgaagaaa tgctggacaa cagggcaacc ttacaagcta tagcctcaga 12060

gtttagttcc cttccatcat atgcagcttt tgctactgct caagaagctt atgagcaggc 12120

tgttgctaat ggtgattctg aagttgttct taaaaagttg aagaagtctt tgaatgtggc 12180

taaatctgaa tttgaccgtg atgcagccat gcaacgtaag ttggaaaaga tggctgatca 12240

agctatgacc caaatgtata aacaggctag atctgaggac aagagggcaa aagttactag 12300

tgctatgcag acaatgcttt tcactatgct tagaaagttg gataatgatg cactcaacaa 12360

cattatcaac aatgcaagag atggttgtgt tcccttgaac ataatacctc ttacaacagc 12420

agccaaacta atggttgtca taccagacta taacacatat aaaaatacgt gtgatggtac 12480

aacatttact tatgcatcag cattgtggga aatccaacag gttgtagatg cagatagtaa 12540

aattgttcaa cttagtgaaa ttagtatgga caattcacct aatttagcat ggcctcttat 12600

tgtaacagct ttaagggcca attctgctgt caaattacag aataatgagc ttagtcctgt 12660

tgcactacga cagatgtctt gtgctgccgg tactacacaa actgcttgca ctgatgacaa 12720

tgcgttagct tattacaaca caacaaaggg aggtaggttt gtacttgcac tgttatccga 12780

tttacaggat ttgaaatggg ctagattccc taagagtgat ggaactggta ctatctatac 12840

agaactggaa ccaccttgta ggtttgttac agacacacct aaaggtccta aagtgaagta 12900

tttatacttt attaaaggat taaacaacct aaatagaggt atggtacttg gtagtttagc 12960

tgccacagta cgtctacaag ctggtaatgc aacagaagtg cctgccaatt caactgtatt 13020

atctttctgt gcttttgctg tagatgctgc taaagcttac aaagattatc tagctagtgg 13080

gggacaacca atcactaatt gtgttaagat gttgtgtaca cacactggta ctggtcaggc 13140

aataacagtt acaccggaag ccaatatgga tcaagaatcc tttggtggtg catcgtgttg 13200

tctgtactgc cgttgccaca tagatcatcc aaatcctaaa ggattttgtg acttaaaagg 13260

taagtatgta caaataccta caacttgtgc taatgaccct gtgggtttta cacttaaaaa 13320

cacagtctgt accgtctgcg gtatgtggaa aggttatggc tgtagttgtg atcaactccg 13380

cgaacccatg cttcagtcag ctgatgcaca atcgttttta aacgggtttg cggtgtaagt 13440

gcagcccgtc ttacaccgtg cggcacaggc actagtactg atgtcgtata cagggctttt 13500

gacatctaca atgataaagt agctggtttt gctaaattcc taaaaactaa ttgttgtcgc 13560

ttccaagaaa aggacgaaga tgacaattta attgattctt actttgtagt taagagacac 13620

actttctcta actaccaaca tgaagaaaca atttataatt tacttaagga ttgtccagct 13680

gttgctaaac atgacttctt taagtttaga atagacggtg acatggtacc acatatatca 13740

cgtcaacgtc ttactaaata cacaatggca gacctcgtct atgctttaag gcattttgat 13800

gaaggtaatt gtgatacatt aaaagaaata cttgtcacat acaattgttg tgatgatgat 13860

tatttcaata aaaaggactg gtatgatttt gtagaaaacc cagatatatt acgcgtatac 13920

gccaacttag gtgaacgtgt acgccaagct ttgttaaaaa cagtacaatt ctgtgatgcc 13980

atgcgaaatg ctggtattgt tggtgtactg acattagata atcaagatct caatggtaac 14040

tggtatgatt tcggtgattt catacaaacc acgccaggta gtggagttcc tgttgtagat 14100

tcttattatt cattgttaat gcctatatta accttgacca gggctttaac tgcagagtca 14160

catgttgaca ctgacttaac aaagccttac attaagtggg atttgttaaa atatgacttc 14220

acggaagaga ggttaaaact ctttgaccgt tattttaaat attgggatca gacataccac 14280

ccaaattgtg ttaactgttt ggatgacaga tgcattctgc attgtgcaaa ctttaatgtt 14340

ttattctcta cagtgttccc acttacaagt tttggaccac tagtgagaaa aatatttgtt 14400

gatggtgttc catttgtagt ttcaactgga taccacttca gagagctagg tgttgtacat 14460

aatcaggatg taaacttaca tagctctaga cttagtttta aggaattact tgtgtatgct 14520

gctgaccctg ctatgcacgc tgcttctggt aatctattac tagataaacg cactacgtgc 14580

ttttcagtag ctgcacttac taacaatgtt gcttttcaaa ctgtcaaacc cggtaatttt 14640

aacaaagact tctatgactt tgctgtgtct aagggtttct ttaaggaagg aagttctgtt 14700

gaattaaaac acttcttctt tgctcaggat ggtaatgctg ctatcagcga ttatgactac 14760

tatcgttata atctaccaac aatgtgtgat atcagacaac tactatttgt agttgaagtt 14820

gttgataagt actttgattg ttacgatggt ggctgtatta atgctaacca agtcatcgtc 14880

aacaacctag acaaatcagc tggttttcca tttaataaat ggggtaaggc tagactttat 14940

tatgattcaa tgagttatga ggatcaagat gcacttttcg catatacaaa acgtaatgtc 15000

atccctacta taactcaaat gaatcttaag tatgccatta gtgcaaagaa tagagctcgc 15060

accgtagctg gtgtctctat ctgtagtact atgaccaata gacagtttca tcaaaaatta 15120

ttgaaatcaa tagccgccac tagaggagct actgtagtaa ttggaacaag caaattctat 15180

ggtggttggc acaacatgtt aaaaactgtt tatagtgatg tagaaaaccc tcaccttatg 15240

ggttgggatt atcctaaatg tgatagagcc atgcctaaca tgcttagaat tatggcctca 15300

cttgttcttg ctcgcaaaca tacaacgtgt tgtagcttgt cacaccgttt ctatagatta 15360

gctaatgagt gtgctcaagt attgagtgaa atggtcatgt gtggcggttc actatatgtt 15420

aaaccaggtg gaacctcatc aggagatgcc acaactgctt atgctaatag tgtttttaac 15480

atttgtcaag ctgtcacggc caatgttaat gcacttttat ctactgatgg taacaaaatt 15540

gccgataagt atgtccgcaa tttacaacac agactttatg agtgtctcta tagaaataga 15600

gatgttgaca cagactttgt gaatgagttt tacgcatatt tgcgtaaaca tttctcaatg 15660

atgatactct ctgacgatgc tgttgtgtgt ttcaatagca cttatgcatc tcaaggtcta 15720

gtggctagca taaagaactt taagtcagtt ctttattatc aaaacaatgt ttttatgtct 15780

gaagcaaaat gttggactga gactgacctt actaaaggac ctcatgaatt ttgctctcaa 15840

catacaatgc tagttaaaca gggtgatgat tatgtgtacc ttccttaccc agatccatca 15900

agaatcctag gggccggctg ttttgtagat gatatcgtaa aaacagatgg tacacttatg 15960

attgaacggt tcgtgtcttt agctatagat gcttacccac ttactaaaca tcctaatcag 16020

gagtatgctg atgtctttca tttgtactta caatacataa gaaagctaca tgatgagtta 16080

acaggacaca tgttagacat gtattctgtt atgcttacta atgataacac ttcaaggtat 16140

tgggaacctg agttttatga ggctatgtac acaccgcata cagtcttaca ggctgttggg 16200

gcttgtgttc tttgcaattc acagacttca ttaagatgtg gtgcttgcat acgtagacca 16260

ttcttatgtt gtaaatgctg ttacgaccat gtcatatcaa catcacataa attagtcttg 16320

tctgttaatc cgtatgtttg caatgctcca ggttgtgatg tcacagatgt gactcaactt 16380

tacttaggag gtatgagcta ttattgtaaa tcacataaac cacccattag ttttccattg 16440

tgtgctaatg gacaagtttt tggtttatat aaaaatacat gtgttggtag cgataatgtt 16500

actgacttta atgcaattgc aacatgtgac tggacaaatg ctggtgatta cattttagct 16560

aacacctgta ctgaaagact caagcttttt gcagcagaaa cgctcaaagc tactgaggag 16620

acatttaaac tgtcttatgg tattgctact gtacgtgaag tgctgtctga cagagaatta 16680

catctttcat gggaagttgg taaacctaga ccaccactta accgaaatta tgtctttact 16740

ggttatcgtg taactaaaaa cagtaaagta caaataggag agtacacctt tgaaaaaggt 16800

gactatggtg atgctgttgt ttaccgaggt acaacaactt acaaattaaa tgttggtgat 16860

tattttgtgc tgacatcaca tacagtaatg ccattaagtg cacctacact agtgccacaa 16920

gagcactatg ttagaattac tggcttatac ccaacactca atatctcaga tgagttttct 16980

agcaatgttg caaattatca aaaggttggt atgcaaaagt attctacact ccagggacca 17040

cctggtactg gtaagagtca ttttgctatt ggcctagctc tctactaccc ttctgctcgc 17100

atagtgtata cagcttgctc tcatgccgct gttgatgcac tatgtgagaa ggcattaaaa 17160

tatttgccta tagataaatg tagtagaatt atacctgcac gtgctcgtgt agattgtttt 17220

gataaattca aagtgaattc aacattagaa cagtatgtct tttgtactgt aaatgcattg 17280

cctgagacga cagcagatat agttgtcttt gatgaaattt caatggccac aaattatgat 17340

ttgagtgttg tcaatgccag attacgtgct aagcactatg tgtacattgg cgaccctgct 17400

caattacctg caccacgcac attgctaact aagggcacac tagaaccaga atatttcaat 17460

tcagtgtgta gacttatgaa aactataggt ccagacatgt tcctcggaac ttgtcggcgt 17520

tgtcctgctg aaattgttga cactgtgagt gctttggttt atgataataa gcttaaagca 17580

cataaagaca aatcagctca atgctttaaa atgttttata agggtgttat cacgcatgat 17640

gtttcatctg caattaacag gccacaaata ggcgtggtaa gagaattcct tacacgtaac 17700

cctgcttgga gaaaagctgt ctttatttca ccttataatt cacagaatgc tgtagcctca 17760

aagattttgg gactaccaac tcaaactgtt gattcatcac agggctcaga atatgactat 17820

gtcatattca ctcaaaccac tgaaacagct cactcttgta atgtaaacag atttaatgtt 17880

gctattacca gagcaaaagt aggcatactt tgcataatgt ctgatagaga cctttatgac 17940

aagttgcaat ttacaagtct tgaaattcca cgtaggaatg tggcaacttt acaagctgaa 18000

aatgtaacag gactctttaa agattgtagt aaggtaatca ctgggttaca tcctacacag 18060

gcacctacac acctcagtgt tgacactaaa ttcaaaactg aaggtttatg tgttgacata 18120

cctggcatac ctaaggacat gacctataga agactcatct ctatgatggg ttttaaaatg 18180

aattatcaag ttaatggtta ccctaacatg tttatcaccc gcgaagaagc tataagacat 18240

gtacgtgcat ggattggctt cgatgtcgag gggtgtcatg ctactagaga agctgttggt 18300

accaatttac ctttacagct aggtttttct acaggtgtta acctagttgc tgtacctaca 18360

ggttatgttg atacacctaa taatacagat ttttccagag ttagtgctaa accaccgcct 18420

ggagatcaat ttaaacacct cataccactt atgtacaaag gacttccttg gaatgtagtg 18480

cgtataaaga ttgtacaaat gttaagtgac acacttaaaa atctctctga cagagtcgta 18540

tttgtcttat gggcacatgg ctttgagttg acatctatga agtattttgt gaaaatagga 18600

cctgagcgca cctgttgtct atgtgataga cgtgccacat gcttttccac tgcttcagac 18660

acttatgcct gttggcatca ttctattgga tttgattacg tctataatcc gtttatgatt 18720

gatgttcaac aatggggttt tacaggtaac ctacaaagca accatgatct gtattgtcaa 18780

gtccatggta atgcacatgt agctagttgt gatgcaatca tgactaggtg tctagctgtc 18840

cacgagtgct ttgttaagcg tgttgactgg actattgaat atcctataat tggtgatgaa 18900

ctgaagatta atgcggcttg tagaaaggtt caacacatgg ttgttaaagc tgcattatta 18960

gcagacaaat tcccagttct tcacgacatt ggtaacccta aagctattaa gtgtgtacct 19020

caagctgatg tagaatggaa gttctatgat gcacagcctt gtagtgacaa agcttataaa 19080

atagaagaat tattctattc ttatgccaca cattctgaca aattcacaga tggtgtatgc 19140

ctattttgga attgcaatgt cgatagatat cctgctaatt ccattgtttg tagatttgac 19200

actagagtgc tatctaacct taacttgcct ggttgtgatg gtggcagttt gtatgtaaat 19260

aaacatgcat tccacacacc agcttttgat aaaagtgctt ttgttaattt aaaacaatta 19320

ccatttttct attactctga cagtccatgt gagtctcatg gaaaacaagt agtgtcagat 19380

atagattatg taccactaaa gtctgctacg tgtataacac gttgcaattt aggtggtgct 19440

gtctgtagac atcatgctaa tgagtacaga ttgtatctcg atgcttataa catgatgatc 19500

tcagctggct ttagcttgtg ggtttacaaa caatttgata cttataacct ctggaacact 19560

tttacaagac ttcagagttt agaaaatgtg gcttttaatg ttgtaaataa gggacacttt 19620

gatggacaac agggtgaagt accagtttct atcattaata acactgttta cacaaaagtt 19680

gatggtgttg atgtagaatt gtttgaaaat aaaacaacat tacctgttaa tgtagcattt 19740

gagctttggg ctaagcgcaa cattaaacca gtaccagagg tgaaaatact caataatttg 19800

ggtgtggaca ttgctgctaa tactgtgatc tgggactaca aaagagatgc tccagcacat 19860

atatctacta ttggtgtttg ttctatgact gacatagcca agaaaccaac tgaaacgatt 19920

tgtgcaccac tcactgtctt ttttgatggt agagttgatg gtcaagtaga cttatttaga 19980

aatgcccgta atggtgttct tattacagaa ggtagtgtta aaggtttaca accatctgta 20040

ggtcccaaac aagctagtct taatggagtc acattaattg gagaagccgt aaaaacacag 20100

ttcaattatt ataagaaagt tgatggtgtt gtccaacaat tacctgaaac ttactttact 20160

cagagtagaa atttacaaga atttaaaccc aggagtcaaa tggaaattga tttcttagaa 20220

ttagctatgg atgaattcat tgaacggtat aaattagaag gctatgcctt cgaacatatc 20280

gtttatggag attttagtca tagtcagtta ggtggtttac atctactgat tggactagct 20340

aaacgtttta aggaatcacc ttttgaatta gaagatttta ttcctatgga cagtacagtt 20400

aaaaactatt tcataacaga tgcgcaaaca ggttcatcta agtgtgtgtg ttctgttatt 20460

gatttattac ttgatgattt tgttgaaata ataaaatccc aagatttatc tgtagtttct 20520

aaggttgtca aagtgactat tgactataca gaaatttcat ttatgctttg gtgtaaagat 20580

ggccatgtag aaacatttta cccaaaatta caatctagtc aagcgtggca accgggtgtt 20640

gctatgccta atctttacaa aatgcaaaga atgctattag aaaagtgtga ccttcaaaat 20700

tatggtgata gtgcaacatt acctaaaggc ataatgatga atgtcgcaaa atatactcaa 20760

ctgtgtcaat atttaaacac attaacatta gctgtaccct ataatatgag agttatacat 20820

tttggtgctg gttctgataa aggagttgca ccaggtacag ctgttttaag acagtggttg 20880

cctacgggta cgctgcttgt cgattcagat cttaatgact ttgtctctga tgcagattca 20940

actttgattg gtgattgtgc aactgtacat acagctaata aatgggatct cattattagt 21000

gatatgtacg accctaagac taaaaatgtt acaaaagaaa atgactctaa agagggtttt 21060

ttcacttaca tttgtgggtt tatacaacaa aagctagctc ttggaggttc cgtggctata 21120

aagataacag aacattcttg gaatgctgat ctttataagc tcatgggaca cttcgcatgg 21180

tggacagcct ttgttactaa tgtgaatgcg tcatcatctg aagcattttt aattggatgt 21240

aattatcttg gcaaaccacg cgaacaaata gatggttatg tcatgcatgc aaattacata 21300

ttttggagga atacaaatcc aattcagttg tcttcctatt ctttatttga catgagtaaa 21360

tttcccctta aattaagggg tactgctgtt atgtctttaa aagaaggtca aatcaatgat 21420

atgattttat ctcttcttag taaaggtaga cttataatta gagaaaacaa cagagttgtt 21480

atttctagtg atgttcttgt taacaactaa acgaacaatg tttgtttttc ttgttttatt 21540

gccactagtc tctagtcagt gtgttaattt tacaaacaga actcaattac cctctgcata 21600

cactaattct ttcacacgtg gtgtttatta ccctgacaaa gttttcagat cctcagtttt 21660

acattcaact caggacttgt tcttaccttt cttttccaat gttacttggt tccatgctat 21720

acatgtctct gggaccaatg gtactaagag gtttgataac cctgtcctac catttaatga 21780

tggtgtttat tttgcttcca ctgagaagtc taacataata agaggctgga tttttggtac 21840

tactttagat tcgaagaccc agtccctact tattgttaat aacgctacta atgttgttat 21900

taaagtctgt gaatttcaat tttgtaatta tccatttttg ggtgtttatt accacaaaaa 21960

caacaaaagt tggatggaaa gtgagttcag agtttattct agtgcgaata attgcacttt 22020

tgaatatgtc tctcagcctt ttcttatgga ccttgaagga aaacagggta atttcaaaaa 22080

tcttagtgaa tttgtgttta agaatattga tggttatttt aaaatatatt ctaagcacac 22140

gcctattaat ttagtgcgtg atctccctca gggtttttcg gctttagaac cattggtaga 22200

tttgccaata ggtattaaca tcactaggtt tcaaacttta cttgctttac atagaagtta 22260

tttgactcct ggtgattctt cttcaggttg gacagctggt gctgcagctt attatgtggg 22320

ttatcttcaa cctaggactt ttctattaaa atataatgaa aatggaacca ttacagatgc 22380

tgtagactgt gcacttgacc ctctctcaga aacaaagtgt acgttgaaat ccttcactgt 22440

agaaaaagga atctatcaaa cttctaactt tagagtccaa ccaacagaat ctattgttag 22500

atttcctaat attacaaact tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc 22560

atctgtttat gcttggaaca ggaagagaat cagcaactgt gttgctgatt attctgtcct 22620

atataattcc gcatcatttt ccacttttaa gtgttatgga gtgtctccta ctaaattaaa 22680

tgatctctgc tttactaatg tctatgcaga ttcatttgta attagaggtg atgaagtcag 22740

acaaatcgct ccagggcaaa ctggaacgat tgctgattat aattataaat taccagatga 22800

ttttacaggc tgcgttatag cttggaattc taacaatctt gattctaagg ttggtggtaa 22860

ttataattac ctgtatagat tgtttaggaa gtctaatctc aaaccttttg agagagatat 22920

ttcaactgaa atctatcagg ccggtagcac accttgtaat ggtgttaaag gttttaattg 22980

ttactttcct ttacaatcat atggtttcca acccacttat ggtgttggtt accaaccata 23040

cagagtagta gtactttctt ttgaacttct acatgcacca gcaactgttt gtggacctaa 23100

aaagtctact aatttggtta aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg 23160

cacaggtgtt cttactgagt ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga 23220

cattgctgac actactgatg ctgtccgtga tccacagaca cttgagattc ttgacattac 23280

accatgttct tttggtggtg tcagtgttat aacaccagga acaaatactt ctaatcaggt 23340

tgctgttctt tatcagggtg ttaactgcac agaagtccct gttgctattc atgcagatca 23400

acttactcct acttggcgtg tttattctac aggttctaat gtttttcaaa cacgtgcagg 23460

ctgtttaata ggggctgaat atgtcaacaa ctcatatgag tgtgacatac ccattggtgc 23520

aggtatatgc gctagttatc agactcagac taattctcct cggcgggcac gtagtgtagc 23580

tagtcaatcc atcattgcct acactatgtc acttggtgca gaaaattcag ttgcttactc 23640

taataactct attgccatac ccacaaattt tactattagt gttaccacag aaattctacc 23700

agtgtctatg accaagacat cagtagattg tacaatgtac atttgtggtg attcaactga 23760

atgcagcaat cttttgttgc aatatggcag tttttgtaca caattaaacc gtgctttaac 23820

tggaatagct gttgaacaag acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat 23880

ttacaaaaca ccaccaatta aagattttgg tggttttaat ttttcacaaa tattaccaga 23940

tccatcaaaa ccaagcaaga ggtcatttat tgaagatcta cttttcaaca aagtgacact 24000

tgcagatgct ggcttcatca aacaatatgg tgattgcctt ggtgatattg ctgctagaga 24060

cctcatttgt gcacaaaagt ttaacggcct tactgttttg ccacctttgc tcacagatga 24120

aatgattgct caatacactt ctgcactgtt agcgggtaca atcacttctg gttggacctt 24180

tggtgcaggt gctgcattac aaataccatt tgctatgcaa atggcttata ggtttaatgg 24240

tattggagtt acacagaatg ttctctatga gaaccaaaaa ttgattgcca accaatttaa 24300

tagtgctatt ggcaaaattc aagactcact ttcttccaca gcaagtgcac ttggaaaact 24360

tcaagatgtg gtcaaccaaa atgcacaagc tttaaacacg cttgttaaac aacttagctc 24420

caattttggt gcaatttcaa gtgttttaaa tgatatcctt tcacgtcttg acaaagttga 24480

ggctgaagtg caaattgata ggttgatcac aggcagactt caaagtttgc agacatatgt 24540

gactcaacaa ttaattagag ctgcagaaat cagagcttct gctaatcttg ctgctattaa 24600

aatgtcagag tgtgtacttg gacaatcaaa aagagttgat ttttgtggaa agggctatca 24660

tcttatgtcc ttccctcagt cagcacctca tggtgtagtc ttcttgcatg tgacttatgt 24720

ccctgcacaa gaaaagaact tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca 24780

ctttcctcgt gaaggtgtct ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa 24840

tttttatgaa ccacaaatca ttactacaga caacacattt gtgtctggta actgtgatgt 24900

tgtaatagga attgtcaaca acacagttta tgatcctttg caacctgaat tagactcatt 24960

caaggaggag ttagataaat attttaagaa tcatacatca ccagatgttg atttaggtga 25020

catctctggc attaatgctt catttgtaaa cattcaaaaa gaaattgacc gcctcaatga 25080

ggttgccaag aatttaaatg aatctctcat cgatctccaa gaacttggaa agtatgagca 25140

gtatataaaa tggccatggt acatttggct aggttttata gctggcttga ttgccatagt 25200

aatggtgaca attatgcttt gctgtatgac cagttgctgt agttgtctca agggctgttg 25260

ttcttgtgga tcctgctgca aatttgatga agacgactct gagccagtgc tcaaaggagt 25320

caaattacat tacacataaa cgaacttatg gatttgttta tgagaatctt cacaattgga 25380

actgtaactt tgaagcaagg tgaaatcaag gatgctactc cttcagattt tgttcgcgct 25440

actgcaacga taccgataca agcctcactc cctttcggat ggcttattgt tggcgttgca 25500

cttcttgctg tttttcagag cgcttccaaa atcataaccc tcaaaaagag atggcaacta 25560

gcactctcca agggtgttca ctttgtttgc aacttgctgt tgttgtttgt aacagtttac 25620

tcacaccttt tgctcgttgc tgctggcctt gaagcccctt ttctctatct ttatgcttta 25680

gtctacttct tgcagagtat aaactttgta agaataataa tgaggctttg gctttgctgg 25740

aaatgccgtt ccaaaaaccc attactttat gatgccaact attttctttg ctggcatact 25800

aattgttacg actattgtat accttacaat agtgtaactt cttcaattgt cattacttca 25860

ggtgatggca caacaagtcc tatttctgaa catgactacc agattggtgg ttatactgaa 25920

aaatgggaat ctggagtaaa agactgtgtt gtattacaca gttacttcac ttcagactat 25980

taccagctgt actcaactca attgagtaca gacactggtg ttgaacatgt taccttcttc 26040

atctacaata aaattgttga tgagcctgaa gaacatgtcc aaattcacac aatcgacggt 26100

tcacccggag ttgttaatcc agtaatggaa ccaatttatg atgaaccgac gacgactact 26160

agcgtgcctt tgtaagcaca agctgatgag tacgaactta tgtactcatt cgtttcggaa 26220

gagacaggta cgttaatagt taatagcgta cttctttttc ttgctttcgt ggtattcttg 26280

ctagttacac tagccatcct tactgcgctt cgattgtgtg cgtactgctg caatattgtt 26340

aacgtgagtc ttgtaaaacc ttctttttac gtttactctc gtgttaaaaa tctgaattct 26400

tctagagttc ctgatcttct ggtctaaacg aactaaatat tatattagtt tttctgtttg 26460

gaactttaat tttagccatg gcagattcca acggtactat taccgttgaa gagcttaaaa 26520

agctccttga acaatggaac ctagtaatag gtttcctatt ccttacatgg atttgtcttc 26580

tacaatttgc ctatgccaac aggaataggt ttttgtatat aattaagtta attttcctct 26640

ggctgttatg gccagtaact ttagcttgtt ttgtgcttgc tgctgtttac agaataaatt 26700

ggatcaccgg tggaattgct atcgcaatgg cttgtcttgt aggcttgatg tggctcagct 26760

acttcattgc ttctttcaga ctgtttgcgc gtacgcgttc catgtggtca ttcaatccag 26820

aaactaacat tcttctcaac gtgccactcc atggcactat tctgaccaga ccgcttctag 26880

aaagtgaact cgtaatcgga gctgtgatcc ttcgtggaca tcttcgtatt gctggacacc 26940

atctaggacg ctgtgacatc aaggacctgc ctaaagaaat cactgttgct acatcacgaa 27000

cgctttctta ttacaaattg ggagcttcgc agcgtgtagc aggtgactca ggttttgctg 27060

catacagtcg ctacaggatt ggcaactata aattaaacac agaccattcc agtagcagtg 27120

acaatattgc tttgcttgta cagtaagtga caacagatgt ttcatctcgt tgactttcag 27180

gttactatag cagagatatt actaattatt atgaggactt ttaaagtttc catttggaat 27240

cttgattaca tcataaacct cataattaaa aatttatcta agtcactaac tgagaataaa 27300

tattctcaat tagatgaaga gcaaccaatg gagattgatt aaacgaacat gaaaattatt 27360

cttttcttgg cactgataac actcgctact tgtgagcttt atcactacca agagtgtgtt 27420

agaggtacaa cagtactttt aaaagaacct tgctcttctg gaacatacga gggcaattca 27480

ccatttcatc ctctagctga taacaaattt gcactgactt gctttagcac tcaatttgct 27540

tttgcttgtc ctgacggcgt aaaacacgtc tatcagttac gtgccagatc agtttcacct 27600

aaactgttca tcagacaaga ggaagttcaa gaactttact ctccaatttt tcttattgtt 27660

gcggcaatag tgtttataac actttgcttc acactcaaaa gaaagacaga atgattgaac 27720

tttcattaat tgacttctat ttgtgctttt tagcctttct gctattcctt gttttaatta 27780

tgcttattat cttttggttc tcacttgaac tgcaagatca taatgaaact tgtcacgcct 27840

aaacgaacat gaaatttctt gttttcttag gaatcatcac aactgtagct gcatttcacc 27900

aagaatgtag tttacagtca tgtactcaac atcaaccata tgtagttgat gacccgtgtc 27960

ctattcactt ctattctaaa tggtatatta gagtaggagc tagaaaatca gcacctttaa 28020

ttgaattgtg cgtggatgag gctggttcta aatcacccat tcagtacatc gatatcggta 28080

attatacagt ttcctgttta ccttttacaa ttaattgcca gaaacctaaa ttgggtagtc 28140

ttgtagtgcg ttgttcgttc tatgaagact ttttagagta tcatgacgtt cgtgttgttt 28200

tagatttcat ctaaacgaac aaacaaacta aaatgtctga taatggaccc caaaatcagc 28260

gaaatgcacc ccgcattacg tttggtggac cctcagattc aactggcagt aaccagaatg 28320

gagaacgcag tggggcgcga tcaaaacaac gtcggcccca aggtttaccc aataatactg 28380

cgtcttggtt caccgctctc actcaacatg gcaaggaaga ccttaaattc cctcgaggac 28440

aaggcgttcc aattaacacc aatagcagtc gagatgacca aattggctac taccgaagag 28500

ctaccagacg aattcgtggt ggtgacggta aaatgaaaga tctcagtcca agatggtatt 28560

tctactacct aggaactggg ccagaagctg gacttcccta tggtgctaac aaagacggca 28620

tcatatgggt tgcaactgag ggagccttga atacaccaaa agatcacatt ggcacccgca 28680

atcctgctaa caatgctgca atcgtgctac aacttcctca aggaacaaca ttgccaaaag 28740

gcttctacgc agaagggagc agaggcggca gtcaagcctc ttctcgttcc tcatcacgta 28800

gtcgcaacag ttcaagaaat tcaactccag gcagctctaa acgaacttct cctgctagaa 28860

tggctggcaa tggcggtgat gctgctcttg ctttgctgct gcttgacaga ttgaaccagc 28920

ttgagagcaa aatgtctggt aaaggccaac aacaacaagg ccaaactgtc actaagaaat 28980

ctgctgctga ggcttctaag aagcctcggc aaaaacgtac tgccactaaa gcatacaatg 29040

taacacaagc tttcggcaga cgtggtccag aacaaaccca aggaaatttt ggggaccagg 29100

aactaatcag acaaggaact gattacaaac attggccgca aattgcacaa tttgccccca 29160

gcgcttcagc gttcttcgga atgtcgcgca ttggcatgga agtcacacct tcgggaacgt 29220

ggttgaccta cacaggtgcc atcaaattgg atgacaaaga tccaaatttc aaagatcaag 29280

tcattttgct gaataagcat attgacgcat acaaaacatt cccaccaaca gagcctaaaa 29340

aggacaaaaa gaagaaggct gatgaaactc aagccttacc gcagagacag aagaaacagc 29400

aaactgtgac tcttcttcct gctgcagatt tggatgattt ctccaaacaa ttgcaacaat 29460

ccatgagcag tgctgactca actcaggcct aaactcatgc agaccacaca aggcagatgg 29520

gctatataaa cgttttcgct tttccgttta cgatatatag tctactcttg tgcagaatga 29580

attctcgtaa ctacatagca caagtagatg tagttaactt taatctcaca tagcaatctt 29640

taatcagtgt gtaacattag ggaggacttg aaagagccac cacattttca ccgaggccac 29700

gcggagtacg atcgagtgta cagtgaacaa tgctagggag agctgcctat atggaagagc 29760

cctaatgtgt aaaattaatt ttagtagtgc taaccccatg tgattttaat agcttctta 29819

<210> 21

<211> 1273

<212> PRT

<213> SARS-CoV2

<400> 21

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val

1 5 10 15

Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe

20 25 30

Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu

35 40 45

His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp

50 55 60

Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp

65 70 75 80

Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu

85 90 95

Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser

100 105 110

Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile

115 120 125

Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly Val Tyr

130 135 140

Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr

145 150 155 160

Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu

165 170 175

Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser Glu Phe

180 185 190

Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr

195 200 205

Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu

210 215 220

Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr

225 230 235 240

Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser

245 250 255

Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro

260 265 270

Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala

275 280 285

Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys

290 295 300

Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val

305 310 315 320

Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys

325 330 335

Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala

340 345 350

Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu

355 360 365

Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro

370 375 380

Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe

385 390 395 400

Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly

405 410 415

Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys

420 425 430

Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn

435 440 445

Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe

450 455 460

Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys

465 470 475 480

Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly

485 490 495

Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val

500 505 510

Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys

515 520 525

Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn

530 535 540

Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu

545 550 555 560

Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val

565 570 575

Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe

580 585 590

Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val

595 600 605

Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile

610 615 620

His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser

625 630 635 640

Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val

645 650 655

Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala

660 665 670

Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala

675 680 685

Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser

690 695 700

Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile

705 710 715 720

Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val

725 730 735

Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu

740 745 750

Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr

755 760 765

Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln

770 775 780

Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe

785 790 795 800

Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser

805 810 815

Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly

820 825 830

Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp

835 840 845

Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu

850 855 860

Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly

865 870 875 880

Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile

885 890 895

Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr

900 905 910

Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn

915 920 925

Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala

930 935 940

Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn

945 950 955 960

Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val

965 970 975

Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln

980 985 990

Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val

995 1000 1005

Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn

1010 1015 1020

Leu Ala Ala Ile Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys

1025 1030 1035

Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro

1040 1045 1050

Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val

1055 1060 1065

Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His

1070 1075 1080

Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn

1085 1090 1095

Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln

1100 1105 1110

Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val

1115 1120 1125

Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro

1130 1135 1140

Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn

1145 1150 1155

His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn

1160 1165 1170

Ala Ser Phe Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu

1175 1180 1185

Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu

1190 1195 1200

Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu

1205 1210 1215

Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met

1220 1225 1230

Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys

1235 1240 1245

Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro

1250 1255 1260

Val Leu Lys Gly Val Lys Leu His Tyr Thr

1265 1270

<210> 22

<211> 29883

<212> DNA

<213> SARS-CoV2

<220>

<221> misc_feature

<222> (29849)..(29883)

<223> n is a, c, g or t

<400> 22

attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct 60

gttctctaaa cgaactttaa aatctgtgtg gctgtcactc ggctgcatgc ttagtgcact 120

cacgcagtat aattaataac taattactgt cgttgacagg acacgagtaa ctcgtctatc 180

ttctgcaggc tgcttacggt ttcgtccgtg ttgcagccga tcatcagcac atctaggttt 240

tgtccgggtg tgaccgaaag gtaagatgga gagccttgtc cctggtttca acgagaaaac 300

acacgtccaa ctcagtttgc ctgttttaca ggttcgcgac gtgctcgtac gtggctttgg 360

agactccgtg gaggaggtct tatcagaggc acgtcaacat cttaaagatg gcacttgtgg 420

cttagtagaa gttgaaaaag gcgttttgcc tcaacttgaa cagccctatg tgttcatcaa 480

acgttcggat gctcgaactg cacctcatgg tcatgttatg gttgagctgg tagcagaact 540

cgaaggcatt cagtacggtc gtagtggtga gacacttggt gtccttgtcc ctcatgtggg 600

cgaaatacca gtggcttacc gcaaggttct tcttcgtaag aacggtaata aaggagctgg 660

tggccatagt tacggcgccg atctaaagtc atttgactta ggcgacgagc ttggcactga 720

tccttatgaa gattttcaag aaaactggaa cactaaacat agcagtggtg ttacccgtga 780

actcatgcgt gagcttaacg gaggggcata cactcgctat gtcgataaca acttctgtgg 840

ccctgatggc taccctcttg agtgcattaa agaccttcta gcacgtgctg gtaaagcttc 900

atgcactttg tctgaacaac tggactttat tgacactaag aggggtgtat actgctgccg 960

tgaacatgag catgaaattg cttggtacac ggaacgttct gaaaagagct atgaattgca 1020

gacacctttt gaaattaaat tggcaaagaa atttgacacc ttcaatgggg aatgtccaaa 1080

ttttgtattt cccttaaatt ccataatcaa gactattcaa ccaagggttg aaaagaaaaa 1140

gcttgatggc tttatgggta gaattcgatc tgtctatcca gttgcgtcac caaatgaatg 1200

caaccaaatg tgcctttcaa ctctcatgaa gtgtgatcat tgtggtgaaa cttcatggca 1260

gacgggcgat tttgttaaag ccacttgcga attttgtggc actgagaatt tgactaaaga 1320

aggtgccact acttgtggtt acttacccca aaatgctgtt gttaaaattt attgtccagc 1380

atgtcacaat tcagaagtag gacctgagca tagtcttgcc gaataccata atgaatctgg 1440

cttgaaaacc attcttcgta agggtggtcg cactattgcc tttggaggct gtgtgttctc 1500

ttatgttggt tgccataaca agtgtgccta ttgggttcca cgtgctagcg ctaacatagg 1560

ttgtaaccat acaggtgttg ttggagaagg ttccgaaggt cttaatgaca accttcttga 1620

aatactccaa aaagagaaag tcaacatcaa tattgttggt gactttaaac ttaatgaaga 1680

gatcgccatt attttggcat ctttttctgc ttccacaagt gcttttgtgg aaactgtgaa 1740

aggtttggat tataaagcat tcaaacaaat tgttgaatcc tgtggtaatt ttaaagttac 1800

aaaaggaaaa gctaaaaaag gtgcctggaa tattggtgaa cagaaatcaa tactgagtcc 1860

tctttatgca tttgcatcag aggctgctcg tgttgtacga tcaattttct cccgcactct 1920

tgaaactgct caaaattctg tgcgtgtttt acagaaggcc gctataacaa tactagatgg 1980

aatttcacag tattcactga gactcattga tgctatgatg ttcacatctg atttggctac 2040

taacaatcta gttgtaatgg cctacattac aggtggtgtt gttcagttga cttcgcagtg 2100

gctaactaac atctttggca ctgtttatga aaaactcaaa cccgtccttg attggcttga 2160

agagaagttt aaggaaggtg tagagtttct tagagacggt tgggaaattg ttaaatttat 2220

ctcaacctgt gcttgtgaaa ttgtcggtgg acaaattgtc acctgtgcaa aggaaattaa 2280

ggagagtgtt cagacattct ttaagcttgt aaataaattt ttggctttgt gtgctgactc 2340

tatcattatt ggtggagcta aacttaaagc cttgaattta ggtgaaacat ttgtcacgca 2400

ctcaaaggga ttgtacagaa agtgtgttaa atccagagaa gaaactggcc tactcatgcc 2460

tctaaaagcc ccaaaagaaa ttatcttctt agagggagaa acacttccca cagaagtgtt 2520

aacagaggaa gttgtcttga aaactggtga tttacaacca ttagaacaac ctactagtga 2580

agctgttgaa gctccattgg ttggtacacc agtttgtatt aacgggctta tgttgctcga 2640

aatcaaagac acagaaaagt actgtgccct tgcacctaat atgatggtaa caaacaatac 2700

cttcacactc aaaggcggtg caccaacaaa ggttactttt ggtgatgaca ctgtgataga 2760

agtgcaaggt tacaagagtg tgaatatcac ttttgaactt gatgaaagga ttgataaagt 2820

acttaatgag aagtgctctg cctatacagt tgaactcggt acagaagtaa atgagttcgc 2880

ctgtgttgtg gcagatgctg tcataaaaac tttgcaacca gtatctgaat tacttacacc 2940

actgggcatt gatttagatg agtggagtat ggctacatac tacttatttg atgagtctgg 3000

tgagtttaaa ttggcttcac atatgtattg ttctttttac cctccagatg aggatgaaga 3060

agaaggtgat tgtgaagaag aagagtttga gccatcaact caatatgagt atggtactga 3120

agatgattac caaggtaaac ctttggaatt tggtgccact tctgctgctc ttcaacctga 3180

agaagagcaa gaagaagatt ggttagatga tgatagtcaa caaactgttg gtcaacaaga 3240

cggcagtgag gacaatcaga caactattat tcaaacaatt gttgaggttc aacctcaatt 3300

agagatggaa cttacaccag ttgttcagac tattgaagtg aatagtttta gtggttattt 3360

aaaacttact gacaatgtat acattaaaaa tgcagacatt gtggaagaag ctaaaaaggt 3420

aaaaccaaca gtggttgtta atgcagccaa tgtttacctt aaacatggag gaggtgttgc 3480

aggagcctta aataaggcta ctaacaatgc catgcaagtt gaatctgatg attacatagc 3540

tactaatgga ccacttaaag tgggtggtag ttgtgtttta agcggacaca atcttgctaa 3600

acactgtctt catgttgtcg gcccaaatgt taacaaaggt gaagacattc aacttcttaa 3660

gagtgcttat gaaaatttta atcagcacga agttctactt gcaccattat tatcagctgg 3720

tatttttggt gctgacccta tacattcttt aagagtttgt gtagatactg ttcgcacaaa 3780

tgtctactta gctgtctttg ataaaaatct ctatgacaaa cttgtttcaa gctttttgga 3840

aatgaagagt gaaaagcaag ttgaacaaaa gatcgctgag attcctaaag aggaagttaa 3900

gccatttata actgaaagta aaccttcagt tgaacagaga aaacaagatg ataagaaaat 3960

caaagcttgt gttgaagaag ttacaacaac tctggaagaa actaagttcc tcacagaaaa 4020

cttgttactt tatattgaca ttaatggcaa tcttcatcca gattctgcca ctcttgttag 4080

tgacattgac atcactttct taaagaaaga tgctccatat atagtgggtg atgttgttca 4140

agagggtgtt ttaactgctg tggttatacc tactaaaaag gctggtggca ctactgaaat 4200

gctagcgaaa gctttgagaa aagtgccaac agacaattat ataaccactt acccgggtca 4260

gggtttaaat ggttacactg tagaggaggc aaagacagtg cttaaaaagt gtaaaagtgc 4320

cttttacatt ctaccatcta ttatctctaa tgagaagcaa gaaattcttg gaactgtttc 4380

ttggaatttg cgagaaatgc ttgcacatgc agaagaaaca cgcaaattaa tgcctgtctg 4440

tgtggaaact aaagccatag tttcaactat acagcgtaaa tataagggta ttaaaataca 4500

agagggtgtg gttgattatg gtgctagatt ttacttttac accagtaaaa caactgtagc 4560

gtcacttatc aacacactta acgatctaaa tgaaactctt gttacaatgc cacttggcta 4620

tgtaacacat ggcttaaatt tggaagaagc tgctcggtat atgagatctc tcaaagtgcc 4680

agctacagtt tctgtttctt cacctgatgc tgttacagcg tataatggtt atcttacttc 4740

ttcttctaaa acacctgaag aacattttat tgaaaccatc tcacttgctg gttcctataa 4800

agattggtcc tattctggac aatctacaca actaggtata gaatttctta agagaggtga 4860

taaaagtgta tattacacta gtaatcctac cacattccac ctagatggtg aagttatcac 4920

ctttgacaat cttaagacac ttctttcttt gagagaagtg aggactatta aggtgtttac 4980

aacagtagac aacattaatc tccacacgca agttgtggac atgtcaatga catatggaca 5040

acagtttggt ccaacttatt tggatggagc tgatgttact aaaataaaac ctcataattc 5100

acatgaaggt aaaacatttt atgttttacc taatgatgac actctacgtg ttgaggcttt 5160

tgagtactac cacacaactg atcctagttt tctgggtagg tacatgtcag cattaaatca 5220

cactaaaaag tggaaatacc cacaagttaa tggtttaact tctattaaat gggcagataa 5280

caactgttat cttgccactg cattgttaac actccaacaa atagagttga agtttaatcc 5340

acctgctcta caagatgctt attacagagc aagggctggt gaagctgata acttttgtgc 5400

acttatctta gcctactgta ataagacagt aggtgagtta ggtgatgtta gagaaacaat 5460

gagttacttg tttcaacatg ccaatttaga ttcttgcaaa agagtcttga acgtggtgtg 5520

taaaacttgt ggacaacagc agacaaccct taagggtgta gaagctgtta tgtacatggg 5580

cacactttct tatgaacaat ttaagaaagg tgttcagata ccttgtacgt gtggtaaaca 5640

agctacaaaa tatctagtac aacaggagtc accttttgtt atgatgtcag caccacctgc 5700

tcagtatgaa cttaagcatg gtacatttac ttgtgctagt gagtacactg gtaattacca 5760

gtgtggtcac tataaacata taacttctaa agaaactttg tattgcatag acggtgcttt 5820

acttacaaag tcctcagaat acaaaggtcc tattacggat gttttctaca aagaaaacag 5880

ttacacaaca accataaaac cagttactta taaattggat ggtgttgttt gtacagaaat 5940

tgaccctaag ttggacaatt attataagaa agacaattct tattttacag agcaaccaat 6000

tgatcttgta ccaaaccaac catatccaaa cgcaagcttc gataatttta agtttgtatg 6060

tgataatatc aaatttgctg atgatttaaa ccagttaact ggttataaga aacctgcttc 6120

aagagagctt aaagttacat ttttccctga cttaaatggt gatgtggtgg ctattgatta 6180

taaacactac acaccctctt ttaagaaagg agctaaattg ttacataaac ctattgtttg 6240

gcatgttaac aatgcaacta ataaagccac gtataaacca aatacctggt gtatacgttg 6300

tctttggagc acaaaaccag ttgaaacatc aaattcgttt gatgtactga agtcagagga 6360

cgcgcaggga atggataatc ttgcctgcga agatctaaaa ccagtctctg aagaagtagt 6420

ggaaaatcct accatacaga aagacgttct tgagtgtaat gtgaaaacta ccgaagttgt 6480

aggagacatt atacttaaac cagcaaataa tagtttaaaa attacagaag aggttggcca 6540

cacagatcta atggctgctt atgtagacaa ttctagtctt actattaaga aacctaatga 6600

attatctaga gtattaggtt tgaaaaccct tgttactcat ggtttagctg ctgttaatag 6660

tgtcccttgg gatactatag ctaattatgc taagcctttt cttaacaaag ttgttagtac 6720

aactactaac atagttacac ggtgtttaaa ccgtgtttgt actaattata tgccttattt 6780

ctttacttta ttgctacaat tgtgtacttt tactagaagt acaaattcta gaattaaagc 6840

atctatgccg actactatag caaagaatac tgttaagagt gtcggtaaat tttgtctaga 6900

ggcttcattt aattatttga agtcacctaa tttttctaaa ctgataaata ttacaatttg 6960

gtttttacta ttaagtgttt gcctaggttc tttaatctac tcaaccgctg ctttaggtgt 7020

tttaatgtct aatttaggca tgccttctta ctgtactggt tacagagaag gctatttgaa 7080

ctctactaat gtcactattg caacctactg tactggttct ataccttgta gtgtttgtct 7140

tagtggttta gattctttag acacctatcc ttctttagaa actatacaaa ttaccatttc 7200

atcttttaaa tgggatttaa ctgcttttgg cttagttgca gagtggtttt tggcatatat 7260

tcttttcact aggtttttct atgtacttgg attggctgca atcatgcaat tgtttttcag 7320

ctattttgca gtacatttta ttagtaattc ttggcttatg tggttaataa ttaatcttgt 7380

acaaatggcc ccgatttcag ctatggttag aatgtacatc ttctttgcat cattttatta 7440

tgtatggaaa agttatgtgc atgttgtaga cggttgtaat tcatcaactt gtatgatgtg 7500

ttacaaacgt aatagagcaa caagagtcga atgtacaact attgttaatg gtgttagaag 7560

gtccttttat gtctatgcta atggaggtaa aggcttttgc aaactacaca attggaattg 7620

tgttaattgt gatacattct gtgctggtag tacatttatt agtgatgaag ttgcgagaga 7680

cttgtcacta cagtttaaaa gaccaataaa tcctactgac cagtcttctt acatcgttga 7740

tagtgttaca gtgaagaatg gttccatcca tctttacttt gataaagctg gtcaaaagac 7800

ttatgaaaga cattctctct ctcattttgt taacttagac aacctgagag ctaataacac 7860

taaaggttca ttgcctatta atgttatagt ttttgatggt aaatcaaaat gtgaagaatc 7920

atctgcaaaa tcagcgtctg tttactacag tcagcttatg tgtcaaccta tactgttact 7980

agatcaggca ttagtgtctg atgttggtga tagtgcggaa gttgcagtta aaatgtttga 8040

tgcttacgtt aatacgtttt catcaacttt taacgtacca atggaaaaac tcaaaacact 8100

agttgcaact gcagaagctg aacttgcaaa gaatgtgtcc ttagacaatg tcttatctac 8160

ttttatttca gcagctcggc aagggtttgt tgattcagat gtagaaacta aagatgttgt 8220

tgaatgtctt aaattgtcac atcaatctga catagaagtt actggcgata gttgtaataa 8280

ctatatgctc acctataaca aagttgaaaa catgacaccc cgtgaccttg gtgcttgtat 8340

tgactgtagt gcgcgtcata ttaatgcgca ggtagcaaaa agtcacaaca ttgctttgat 8400

atggaacgtt aaagatttca tgtcattgtc tgaacaacta cgaaaacaaa tacgtagtgc 8460

tgctaaaaag aataacttac cttttaagtt gacatgtgca actactagac aagttgttaa 8520

tgttgtaaca acaaagatag cacttaaggg tggtaaaatt gttaataatt ggttgaagca 8580

gttaattaaa gttacacttg tgttcctttt tgttgctgct attttctatt taataacacc 8640

tgttcatgtc atgtctaaac atactgactt ttcaagtgaa atcataggat acaaggctat 8700

tgatggtggt gtcactcgtg acatagcatc tacagatact tgttttgcta acaaacatgc 8760

tgattttgac acatggttta gccagcgtgg tggtagttat actaatgaca aagcttgccc 8820

attgattgct gcagtcataa caagagaagt gggttttgtc gtgcctggtt tgcctggcac 8880

gatattacgc acaactaatg gtgacttttt gcatttctta cctagagttt ttagtgcagt 8940

tggtaacatc tgttacacac catcaaaact tatagagtac actgactttg caacatcagc 9000

ttgtgttttg gctgctgaat gtacaatttt taaagatgct tctggtaagc cagtaccata 9060

ttgttatgat accaatgtac tagaaggttc tgttgcttat gaaagtttac gccctgacac 9120

acgttatgtg ctcatggatg gctctattat tcaatttcct aacacctacc ttgaaggttc 9180

tgttagagtg gtaacaactt ttgattctga gtactgtagg cacggcactt gtgaaagatc 9240

agaagctggt gtttgtgtat ctactagtgg tagatgggta cttaacaatg attattacag 9300

atctttacca ggagttttct gtggtgtaga tgctgtaaat ttacttacta atatgtttac 9360

accactaatt caacctattg gtgctttgga catatcagca tctatagtag ctggtggtat 9420

tgtagctatc gtagtaacat gccttgccta ctattttatg aggtttagaa gagcttttgg 9480

tgaatacagt catgtagttg cctttaatac tttactattc cttatgtcat tcactgtact 9540

ctgtttaaca ccagtttact cattcttacc tggtgtttat tctgttattt acttgtactt 9600

gacattttat cttactaatg atgtttcttt tttagcacat attcagtgga tggttatgtt 9660

cacaccttta gtacctttct ggataacaat tgcttatatc atttgtattt ccacaaagca 9720

tttctattgg ttctttagta attacctaaa gagacgtgta gtctttaatg gtgtttcctt 9780

tagtactttt gaagaagctg cgctgtgcac ctttttgtta aataaagaaa tgtatctaaa 9840

gttgcgtagt gatgtgctat tacctcttac gcaatataat agatacttag ctctttataa 9900

taagtacaag tattttagtg gagcaatgga tacaactagc tacagagaag ctgcttgttg 9960

tcatctcgca aaggctctca atgacttcag taactcaggt tctgatgttc tttaccaacc 10020

accacaaacc tctatcacct cagctgtttt gcagagtggt tttagaaaaa tggcattccc 10080

atctggtaaa gttgagggtt gtatggtaca agtaacttgt ggtacaacta cacttaacgg 10140

tctttggctt gatgacgtag tttactgtcc aagacatgtg atctgcacct ctgaagacat 10200

gcttaaccct aattatgaag atttactcat tcgtaagtct aatcataatt tcttggtaca 10260

ggctggtaat gttcaactca gggttattgg acattctatg caaaattgtg tacttaagct 10320

taaggttgat acagccaatc ctaagacacc taagtataag tttgttcgca ttcaaccagg 10380

acagactttt tcagtgttag cttgttacaa tggttcacca tctggtgttt accaatgtgc 10440

tatgaggccc aatttcacta ttaagggttc attccttaat ggttcatgtg gtagtgttgg 10500

ttttaacata gattatgact gtgtctcttt ttgttacatg caccatatgg aattaccaac 10560

tggagttcat gctggcacag acttagaagg taacttttat ggaccttttg ttgacaggca 10620

aacagcacaa gcagctggta cggacacaac tattacagtt aatgttttag cttggttgta 10680

cgctgctgtt ataaatggag acaggtggtt tctcaatcga tttaccacaa ctcttaatga 10740

ctttaacctt gtggctatga agtacaatta tgaacctcta acacaagacc atgttgacat 10800

actaggacct ctttctgctc aaactggaat tgccgtttta gatatgtgtg cttcattaaa 10860

agaattactg caaaatggta tgaatggacg taccatattg ggtagtgctt tattagaaga 10920

tgaatttaca ccttttgatg ttgttagaca atgctcaggt gttactttcc aaagtgcagt 10980

gaaaagaaca atcaagggta cacaccactg gttgttactc acaattttga cttcactttt 11040

agttttagtc cagagtactc aatggtcttt gttctttttt ttgtatgaaa atgccttttt 11100

accttttgct atgggtatta ttgctatgtc tgcttttgca atgatgtttg tcaaacataa 11160

gcatgcattt ctctgtttgt ttttgttacc ttctcttgcc actgtagctt attttaatat 11220

ggtctatatg cctgctagtt gggtgatgcg tattatgaca tggttggata tggttgatac 11280

tagtttgaag ctaaaagact gtgttatgta tgcatcagct gtagtgttac taatccttat 11340

gacagcaaga actgtgtatg atgatggtgc taggagagtg tggacactta tgaatgtctt 11400

gacactcgtt tataaagttt attatggtaa tgctttagat caagccattt ccatgtgggc 11460

tcttataatc tctgttactt ctaactactc aggtgtagtt acaactgtca tgtttttggc 11520

cagaggtatt gtttttatgt gtgttgagta ttgccctatt ttcttcataa ctggtaatac 11580

acttcagtgt ataatgctag tttattgttt cttaggctat ttttgtactt gttactttgg 11640

cctcttttgt ttactcaacc gctactttag actgactctt ggtgtttatg attacttagt 11700

ttctacacag gagtttagat atatgaattc acagggacta ctcccaccca agaatagcat 11760

agatgccttc aaactcaaca ttaaattgtt gggtgttggt ggcaaacctt gtatcaaagt 11820

agccactgta cagtctaaaa tgtcagatgt aaagtgcaca tcartagtct tactctcagt 11880

tttgcaacaa ctcagagtag aatcatcatc taaattgtgg gctcaatgtg tccagttaca 11940

caatgacatt ctcttagcta aagatactac tgaagccttt gaaaaaatgg tttcactact 12000

ttctgttttg ctttccatgc agggtgctgt agacataaac aagctttgtg aagaaatgct 12060

ggacaacagg gcaaccttac aagctatagc ctcagagttt agttcccttc catcatatgc 12120

agcttttgct actgctcaag aagcttatga gcaggctgtt gctaatggtg attctgaagt 12180

tgttcttaaa aagttgaaga agtctttgaa tgtggctaaa tctgaatttg accgtgatgc 12240

agccatgcaa cgtaagttgg aaaagatggc tgatcaagct atgacccaaa tgtataaaca 12300

ggctagatct gaggacaaga gggcaaaagt tactagtgct atgcagacaa tgcttttcac 12360

tatgcttaga aagttggata atgatgcact caacaacatt atcaacaatg caagagatgg 12420

ttgtgttccc ttgaacataa tacctcttac aacagcagcc aaactaatgg ttgtcatacc 12480

agactataac acatataaaa atacgtgtga tggtacaaca tttacttatg catcagcatt 12540

gtgggaaatc caacaggttg tagatgcaga tagtaaaatt gttcaactta gtgaaattag 12600

tatggacaat tcacctaatt tagcatggcc tcttattgta acagctttaa gggccaattc 12660

tgctgtcaaa ttacagaata atgagcttag tcctgttgca ctacgacaga tgtcttgtgc 12720

tgccggtact acacaaactg cttgcactga tgacaatgcg ttagcttact acaacacaac 12780

aaagggaggt aggtttgtac ttgcactgtt atccgattta caggatttga aatgggctag 12840

attccctaag agtgatggaa ctggtactat ctatacagaa ctggaaccac cttgtaggtt 12900

tgttacagac acacctaaag gtcctaaagt gaagtattta tactttatta aaggattaaa 12960

caacctaaat agaggtatgg tacttggtag tttagctgcc acagtacgtc tacaagctgg 13020

taatgcaaca gaagtgcctg ccaattcaac tgtattatct ttctgtgctt ttgctgtaga 13080

tgctgctaaa gcttacaaag attatctagc tagtggggga caaccaatca ctaattgtgt 13140

taagatgttg tgtacacaca ctggtactgg tcaggcaata acagttacac cggaagccaa 13200

tatggatcaa gaatcctttg gtggtgcatc gtgttgtctg tactgccgtt gccacataga 13260

tcatccaaat cctaaaggat tttgtgactt aaaaggtaag tatgtacaaa tacctacaac 13320

ttgtgctaat gaccctgtgg gttttacact taaaaacaca gtctgtaccg tctgcggtat 13380

gtggaaaggt tatggctgta gttgtgatca actccgcgaa cccatgcttc agtcagctga 13440

tgcacaatcg tttttaaacg ggtttgcggt gtaagtgcag cccgtcttac accgtgcggc 13500

acaggcacta gtactgatgt cgtatacagg gcttttgaca tctacaatga taaagtagct 13560

ggttttgcta aattcctaaa aactaattgt tgtcgcttcc aagaaaagga cgaagatgac 13620

aatttaattg attcttactt tgtagttaag agacacactt tctctaacta ccaacatgaa 13680

gaaacaattt ataatttact taaggattgt ccagctgttg ctaaacatga cttctttaag 13740

tttagaatag acggtgacat ggtaccacat atatcacgtc aacgtcttac taaatacaca 13800

atggcagacc tcgtctatgc tttaaggcat tttgatgaag gtaattgtga cacattaaaa 13860

gaaatacttg tcacatacaa ttgttgtgat gatgattatt tcaataaaaa ggactggtat 13920

gattttgtag aaaacccaga tatattacgc gtatacgcca acttaggtga acgtgtacgc 13980

caagctttgt taaaaacagt acaattctgt gatgccatgc gaaatgctgg tattgttggt 14040

gtactgacat tagataatca agatctcaat ggtaactggt atgatttcgg tgatttcata 14100

caaaccacgc caggtagtgg agttcctgtt gtagattctt attattcatt gttaatgcct 14160

atattaacct tgaccagggc tttaactgca gagtcacatg ttgacactga cttaacaaag 14220

ccttacatta agtgggattt gttaaaatat gacttcacgg aagagaggtt aaaactcttt 14280

gaccgttatt ttaaatattg ggatcagaca taccacccaa attgtgttaa ctgtttggat 14340

gacagatgca ttctgcattg tgcaaacttt aatgttttat tctctacagt gttcccactt 14400

acaagttttg gaccactagt gagaaaaata tttgttgatg gtgttccatt tgtagtttca 14460

actggatacc acttcagaga gctaggtgtt gtacataatc aggatgtaaa cttacatagc 14520

tctagactta gttttaagga attacttgtg tatgctgctg accctgctat gcacgctgct 14580

tctggtaatc tattactaga taaacgcact acgtgctttt cagtagctgc acttactaac 14640

aatgttgctt ttcaaactgt caaacctggt aattttaaca aagacttcta tgactttgct 14700

gtgtctaagg gtttctttaa ggaaggaagt tctgttgaat taaaacactt cttctttgct 14760

caggatggta atgctgctat cagcgattat gactactatc gttataatct accaacaatg 14820

tgtgatatca gacaactact atttgtagtt gaagttgttg ataagtactt tgattgttac 14880

gatggtggct gtattaatgc taaccaagtc atcgtcaaca acctagacaa atcagctggt 14940

tttccattta ataaatgggg taaggctaga ctttattatg attcaatgag ttatgaggat 15000

caagatgcac ttttcgcata tacaaaacgt aatgtcatcc ctactataac tcaaatgaat 15060

cttaagtatg ccattagtgc aaagaataga gctcgcaccg tagctggtgt ctctatctgt 15120

agtactatga ccaatagaca gtttcatcaa aaattattga aatcaatagc cgccactaga 15180

ggagctactg tagtaattgg aacaagcaaa ttctatggtg gttggcacaa catgttaaaa 15240

actgtttata gtgatgtaga aaaccctcat cttatgggtt gggattatcc taaatgtgat 15300

agagccatgc ctaacatgct tagaattatg gcctcacttg ttcttgctcg caaacataca 15360

acgtgttgta gcttgtcaca ccgtttctat agattagcta atgagtgtgc tcaagtattg 15420

agtgaaatgg tcatgtgtgg cggttcacta tatgttaaac caggtggaac ctcatcagga 15480

gatgccacaa ctgcttatgc taatagtgtt tttaacattt gtcaagctgt cacggccaat 15540

gttaatgcac ttttatctac tgatggtaac aaaattgccg ataagtatgt ccgcaattta 15600

caacacagac tttatgagtg tctctataga aatagagatg ttgacacaga ctttgtgaat 15660

gagttttacg catatttgcg taaacatttc tcaatgatga tactctctga cgatgctgtt 15720

gtgtgtttca atagcactta tgcatctcaa ggtctagtgg ctagcataaa gaactttaag 15780

tcagttcttt attatcaaaa caatgttttt atgtctgaag caaaatgttg gactgagact 15840

gaccttacta aaggacctca tgaattttgc tctcaacata caatgctagt taaacagggt 15900

gatgattatg tgtaccttcc ttacccagat ccatcaagaa tcctaggggc cggctgtttt 15960

gtagatgata tcgtaaaaac agatggtaca cttatgattg aacggttcgt gtctttagct 16020

atagatgctt acccacttac taaacatcct aatcaggagt atgctgatgt ctttcatttg 16080

tacttacaat acataagaaa gctacatgat gagttaacag gacacatgtt agacatgtat 16140

tctgttatgc ttactaatga taacacctca aggtattggg aacctgagtt ttatgaggct 16200

atgtacacac cgcatacagt cttacaggct gttggggctt gtgttctttg caattcacag 16260

acttcattaa gatgtggtgc ttgcatacgt agaccattct tatgttgtaa atgctgttac 16320

gaccatgtca tatcaacatc acataaatta gtcttgtctg ttaatccgta tgtttgcaat 16380

gctccaggtt gtgatgtcac agatgtgact caactttact taggaggtat gagctattat 16440

tgtaaatcac ataaaccacc cattagtttt ccattgtgtg ctaatggaca agtttttggt 16500

ttatataaaa atacatgtgt tggtagcgat aatgttactg actttaatgc aattgcaaca 16560

tgtgactgga caaatgctgg tgattacatt ttagctaaca cctgtactga aagactcaag 16620

ctttttgcag cagaaacgct caaagctact gaggagacat ttaaactgtc ttatggtatt 16680

gctactgtac gtgaagtgct gtctgacaga gaattacatc tttcatggga agttggtaaa 16740

cctagaccac cacttaaccg aaattatgtc tttactggtt atcgtgtaac taaaaacagt 16800

aaagtacaaa taggagagta cacctttgaa aaaggtgact atggtgatgc tgttgtttac 16860

cgaggtacaa caacttacaa attaaatgtt ggtgattatt ttgtgctgac atcacataca 16920

gtaatgccat taagtgcacc tacactagtg ccacaagagc actatgttag aattactggc 16980

ttatacccaa cactcaatat ctcagatgag ttttctagca atgttgcaaa ttatcaaaag 17040

gttggtatgc aaaagtattc tacactccag ggaccacctg gtactggtaa gagtcatttt 17100

gctattggcc tagctctcta ctacccttct gctcgcatag tgtatacagc ttgctctcat 17160

gccgctgttg atgcactatg tgagaaggca ttaaaatatt tgcctataga taaatgtagt 17220

agaattatac ctgcacgtgc tcgtgtagag tgttttgata aattcaaagt gaattcaaca 17280

ttagaacagt atgtcttttg tactgtaaat gcattgcctg agacgacagc agatatagtt 17340

gtctttgatg aaatttcaat ggccacaaat tatgatttga gtgttgtcaa tgccagatta 17400

cgtgctaagc actatgtgta cattggcgac cctgctcaat tacctgcacc acgcacattg 17460

ctaactaagg gcacactaga accagaatat ttcaattcag tgtgtagact tatgaaaact 17520

ataggtccag acatgttcct cggaacttgt cggcgttgtc ctgctgaaat tgttgacact 17580

gtgagtgctt tggtttatga taataggctt aaagcacata aagacaaatc agctcaatgc 17640

tttaaaatgt tttataaggg tgttatcacg catgatgttt catctgcaat taacaggcca 17700

caaataggcg tggtaagaga attccttaca cgtaaccctg cttggagaaa agctgtcttt 17760

atttcacctt ataattcaca gaatgctgta gcctcaaaga ttttgggact accaactcaa 17820

actgttgatt catcacaggg ctcagaatat gactatgtca tattcactca aaccactgaa 17880

acagctcact cttgtaatgt aaacagattt aatgttgcta ttaccagagc aaaagtaggc 17940

atactttgca taatgtctga tagagacctt tatgacaagt tgcaatttac aagtcttgaa 18000

attccacgta ggaatgtggc aactttacaa gctgaaaatg taacaggact ctttaaagat 18060

tgtagtaagg taatcactgg gttacatcct acacaggcac ctacacacct cagtgttgac 18120

actaaattca aaactgaagg tttatgtgtt gacatacctg gcatacctaa ggacatgacc 18180

tatagaagac tcatctctat gatgggtttt aaaatgaatt atcaagttaa tggttaccct 18240

aacatgttta tcacccgcga agaagctata agacatgtac gtgcatggat tggcttcgat 18300

gtcgaggggt gtcatgctac tagagaagct gttggtacca atttaccttt acagctaggt 18360

ttttctacag gtgttaacct agttgctgta cctacaggtt atgttgatac acctaataat 18420

acagattttt ccagagttag tgctaaacca ccgcctggag atcaatttaa acacctcata 18480

ccacttatgt acaaaggact tccttggaat gtagtgcgta taaagattgt acaaatgtta 18540

agtgacacac ttaaaaatct ctctgacaga gtcgtatttg tcttatgggc acatggcttt 18600

gagttgacat ctatgaagta ttttgtgaaa ataggacctg agcgcacctg ttgtctatgt 18660

gatagacgtg ccacatgctt ttccactgct tcagacactt atgcctgttg gcatcattct 18720

attggatttg attacgtcta taatccgttt atgattgatg ttcaacaatg gggttttaca 18780

ggtaacctac aaagcaacca tgatctgtat tgtcaagtcc atggtaatgc acatgtagct 18840

agttgtgatg caatcatgac taggtgtcta gctgtccacg agtgctttgt taagcgtgtt 18900

gactggacta ttgaatatcc tataattggt gatgaactga agattaatgc ggcttgtaga 18960

aaggttcaac acatggttgt taaagctgca ttattagcag acaaattccc agttcttcac 19020

gacattggta accctaaagc tattaagtgt gtacctcaag ctgatgtagg atggaagttc 19080

tatgatgcac agccttgtag tgacaaagct tataaaatag aagaattatt ctattcttat 19140

gccacacatt ctgacaaatt cacagatggt gtatgcctat tttggaattg caatgtcgat 19200

agatatcctg ctaattccat tgtttgtaga tttgacacta gagtgctatc taaccttaac 19260

ttgcctggtt gtgatggtgg cagtttgtat gtaaataaac atgcattcca cacaccagct 19320

tttgataaaa gtgcttttgt taatttaaaa caattaccat ttttctatta ctctgacagt 19380

ccatgtgagt ctcatggaaa acaagtagtg tcagatatag attatgtacc actaaagtct 19440

gctacgtgta taacacgttg caatttaggt ggtgctgtct gtagacatca tgctaatgag 19500

tacagattgt atctcgatgc ttataacatg atgatctcag ctggctttag cttgtgggtt 19560

tacaaacaat ttgatactta taacctctgg aacactttta caagacttca gagtttagaa 19620

aatgtggctt ttaatgttgt aaataaggga cactttgatg gacaacaggg tgaagtacca 19680

gtttctatca ttaataacac tgtttacaca aaagttgatg gtgttgatgt agaattgttt 19740

gaaaataaaa caacattacc tgttaatgta gcatttgagc tttgggctaa gcgcaacatt 19800

aaaccagtac cagaggtgaa aatactcaat aatttgggtg tggatattgc tgctaatact 19860

gtgatctggg actacaaaag agatgctcca gcacatatat ctactattgg tgtttgttct 19920

atgactgaca tagccaagaa accaactgaa acgatttgtg caccactcac tgtctttttt 19980

gatggtagag ttgatggtca agtagactta tttagaaatg cccgtaatgg tgttcttatt 20040

acagaaggta gtgttaaagg tttacaacca tctgtaggtc ccaaacaagc tagtcttaat 20100

ggagtcacat taattggaga agccgtaaaa acacagttca attattataa gaaagttgat 20160

ggtgttgtcc aacaattacc tgaaacttac tttactcaga gtagaaattt acaagaattt 20220

aaacccagga gtcaaatgga aattgatttc ttagaattag ctatggatga attcattgaa 20280

cggtataaat tagaaggcta tgccttcgaa catatcgttt atggagattt tagtcatagt 20340

cagttaggtg gtttacatct actgattgga ctagctaaac gttttaagga atcacctttt 20400

gaattagaag attttattcc tatggacagt acagttaaaa actatttcat aacagatgcg 20460

caaacaggtt catctaagtg tgtgtgttct gttattgatt tattacttga tgattttgtt 20520

gaaataataa aatcccaaga tttatctgta gtttctaagg ttgtcaaagt gactattgac 20580

tatacagaaa tttcatttat gctttgtgta aagatggcca tgtagaaaca ttttacccaa 20640

aattacaatc tagtcaagcg tggcaaccgg gtgttgctat gcctaatctt tacaaaatgc 20700

aaagaatgct attagaaaag tgtgaccttc aaaattatgg tgatagtgca acattaccta 20760

aaggcataat gatgaatgtc gcaaaatata ctcaactgtg tcaatattta aacacattaa 20820

cattagctgt accctataat atgagagtta tacattttgg tgctggttct gataaaggag 20880

ttgcaccagg tacagctgtt ttaagacagt ggttgcctac gggtacgctg cttgtcgatt 20940

cagatcttaa tgactttgtc tctgatgcag attcaacttt gattggtgat tgtgcaactg 21000

tacatacagc taataaatgg gatctcatta ttagtgatat gtacgaccct aagactaaaa 21060

atgttacaaa agaaaatgac tctaaagagg gttttttcac ttacatttgt gggtttatac 21120

aacaaaagct agctcttgga ggttccgtgg ctataaagat aacagaacat tcttggaatg 21180

ctgatcttta taagctcatg ggacacttcg catggtggac agcctttgtt actaatgtga 21240

atgcgtcatc atctgaagca tttttaattg gatgtaatta tcttggcaaa ccacgcgaac 21300

aaatagatgg ttatgtcatg catgcaaatt acatattttg gaggaataca aatccaattc 21360

agttgtcttc ctattcttta tttgacatga gtaaatttcc ccttaaatta aggggtactg 21420

ctgttatgtc tttaaaagaa ggtcaaatca atgatatgat tttatctctt cttagtaaag 21480

gtagacttat aattagagaa aacaacagag ttgttatttc tagtgatgtt cttgttaaca 21540

actaaacgaa caatgtttgt ttttcttgtt ttattgccac tagtctctag tcagtgtgtt 21600

aatcttacaa ccagaactca attaccccct gcatacacta attctttcac acgtggtgtt 21660

tattaccctg acaaagtttt cagatcctca gttttacatt caactcagga cttgttctta 21720

cctttctttt ccaatgttac ttggttccat gctatctctg ggaccaatgg tactaagagg 21780

tttgataacc ctgtcctacc atttaatgat ggtgtttatt ttgcttccac tgagaagtct 21840

aacataataa gaggctggat ttttggtact actttagatt cgaagaccca gtccctactt 21900

attgttaata acgctactaa tgttgttatt aaagtctgtg aatttcaatt ttgtaatgat 21960

ccatttttgg gtgtttacca caaaaacaac aaaagttgga tggaaagtga gttcagagtt 22020

tattctagtg cgaataattg cacttttgaa tatgtctctc agccttttct tatggacctt 22080

gaaggaaaac agggtaattt caaaaatctt agggaatttg tgtttaagaa tattgatggt 22140

tattttaaaa tatattctaa gcacacgcct attaatttag tgcgtgatct ccctcagggt 22200

ttttcggctt tagaaccatt ggtagatttg ccaataggta ttaacatcac taggtttcaa 22260

actttacttg ctttacatag aagttatttg actcctggtg attcttcttc aggttggaca 22320

gctggtgctg cagcttatta tgtgggttat cttcaaccta ggacttttct attaaaatat 22380

aatgaaaatg gaaccattac agatgctgta gactgtgcac ttgaccctct ctcagaaaca 22440

aagtgtacgt tgaaatcctt cactgtagaa aaaggaatct atcaaacttc taactttaga 22500

gtccaaccaa cagaatctat tgttagattt cctaatatta caaacttgtg cccttttggt 22560

gaagttttta acgccaccag atttgcatct gtttatgctt ggaacaggaa gagaatcagc 22620

aactgtgttg ctgattattc tgtcctatat aattccgcat cattttccac ttttaagtgt 22680

tatggagtgt ctcctactaa attaaatgat ctctgcttta ctaatgtcta tgcagattca 22740

tttgtaatta gaggtgatga agtcagacaa atcgctccag ggcaaactgg aaagattgct 22800

gattataatt ataaattacc agatgatttt acaggctgcg ttatagcttg gaattctaac 22860

aatcttgatt ctaaggttgg tggtaattat aattacctgt atagattgtt taggaagtct 22920

aatctcaaac cttttgagag agatatttca actgaaatct atcaggccgg tagcacacct 22980

tgtaatggtg ttgaaggttt taattgttac tttcctttac aatcatatgg tttccaaccc 23040

acttatggtg ttggttacca accatacaga gtagtagtac tttcttttga acttctacat 23100

gcaccagcaa ctgtttgtgg acctaaaaag tctactaatt tggttaaaaa caaatgtgtc 23160

aatttcaact tcaatggttt aacaggcaca ggtgttctta ctgagtctaa caaaaagttt 23220

ctgcctttcc aacaatttgg cagagacatt gatgacacta ctgatgctgt ccgtgatcca 23280

cagacacttg agattcttga cattacacca tgttcttttg gtggtgtcag tgttataaca 23340

ccaggaacaa atacttctaa ccaggttgct gttctttatc agggtgttaa ctgcacagaa 23400

gtccctgttg ctattcatgc agatcaactt actcctactt ggcgtgttta ttctacaggt 23460

tctaatgttt ttcaaacacg tgcaggctgt ttaatagggg ctgaacatgt caacaactca 23520

tatgagtgtg acatacccat tggtgcaggt atatgcgcta gttatcagac tcagactaat 23580

tctcatcggc gggcacgtag tgtagctagt caatccatca ttgcctacac tatgtcactt 23640

ggtgcagaaa attcagttgc ttactctaat aactctattg ccatacccat aaattttact 23700

attagtgtta ccacagaaat tctaccagtg tctatgacca agacatcagt agattgtaca 23760

atgtacattt gtggtgattc aactgaatgc agcaatcttt tgttgcaata tggcagtttt 23820

tgtacacaat taaaccgtgc tttaactgga atagctgttg aacaagacaa aaacacccaa 23880

gaagtttttg cacaagtcaa acaaatttac aaaacaccac caattaaaga ttttggtggt 23940

tttaattttt cacaaatatt accagatcca tcaaaaccaa gcaagaggtc atttattgaa 24000

gatctacttt tcaacaaagt gacacttgca gatgctggct tcatcaaaca atatggtgat 24060

tgccttggtg atattgctgc tagagacctc atttgtgcac aaaagtttaa cggccttact 24120

gttttgccac ctttgctcac agatgaaatg attgctcaat acacttctgc actgttagcg 24180

ggtacaatca cttctggttg gacctttggt gcaggtgctg cattacaaat accatttgct 24240

atgcaaatgg cttataggtt taatggtatt ggagttacac agaatgttct ctatgagaac 24300

caaaaattga ttgccaacca atttaatagt gctattggca aaattcaaga ctcactttct 24360

tccacagcaa gtgcacttgg aaaacttcaa gatgtggtca accaaaatgc acaagcttta 24420

aacacgcttg ttaaacaact tagctccaat tttggtgcaa tttcaagtgt tttaaatgat 24480

atccttgcac gtcttgacaa agttgaggct gaagtgcaaa ttgataggtt gatcacaggc 24540

agacttcaaa gtttgcagac atatgtgact caacaattaa ttagagctgc agaaatcaga 24600

gcttctgcta atcttgctgc tactaaaatg tcagagtgtg tacttggaca atcaaaaaga 24660

gttgattttt gtggaaaggg ctatcatctt atgtccttcc ctcagtcagc acctcatggt 24720

gtagtcttct tgcatgtgac ttatgtccct gcacaagaaa agaacttcac aactgctcct 24780

gccatttgtc atgatggaaa agcacacttt cctcgtgaag gtgtctttgt ttcaaatggc 24840

acacactggt ttgtaacaca aaggaatttt tatgaaccac aaatcattac tacacacaac 24900

acatttgtgt ctggtaactg tgatgttgta ataggaattg tcaacaacac agtttatgat 24960

cctttgcaac ctgaattaga ctcattcaag gaggagttag ataaatattt taagaatcat 25020

acatcaccag atgttgattt aggtgacatc tctggcatta atgcttcagt tgtaaacatt 25080

caaaaagaaa ttgaccgcct caatgaggtt gccaagaatt taaatgaatc tctcatcgat 25140

ctccaagaac ttggaaagta tgagcagtat ataaaatggc catggtacat ttggctaggt 25200

tttatagctg gcttgattgc catagtaatg gtgacaatta tgctttgctg tatgaccagt 25260

tgctgtagtt gtctcaaggg ctgttgttct tgtggatcct gctgcaaatt tgatgaagac 25320

gactctgagc cagtgctcaa aggagtcaaa ttacattaca cataaacgaa cttatggatt 25380

tgtttatgag aatcttcaca attggaactg taactttgaa gcaaggtgaa atcaaggatg 25440

ctactccttc agattttgtt cgcgctactg caacgatacc gatacaagcc tcactccctt 25500

tcggatggct tattgttggc gttgcacttc ttgctgtttt tcagagcgct tccaaaatca 25560

taaccctcaa aaagagatgg caactagcac tctccaaggg tgttcacttt gtttgcaact 25620

tgctgttgtt gtttgtaaca gtttactcac accttttgct cgttgctgct ggccttgaag 25680

ccccttttct ctatctttat gctttagtct acttcttgca gagtataaac tttgtaagaa 25740

taataatgag gctttggctt tgctggaaat gccgttccaa aaacccatta ctttatgatg 25800

ccaactattt tctttgctgg catactaatt gttacgacta ttgtatacct tacaatagtg 25860

taacttcttc aattgtcatt acttcaggtg atggcacaac aagtcctatt tctgaacatg 25920

actaccagat tggtggttat actgaaaaat gggaatctgg agtaaaagac tgtgttgtat 25980

tacacagtta cttcacttca gactattacc agctgtactc aactcaattg agtacagaca 26040

ctggtgttga acatgttacc ttcttcatct acaataaaat tgttgatgag cctgaagaac 26100

atgtccaaat tcacacaatc gacggttcat ccggagttgt taatccagta atggaaccaa 26160

tttatgatga accgacgacg actactagcg tgcctttgta agcacaagct gatgagtacg 26220

aacttatgta ctcattcgtt tcggaagaga caggtacgtt aatagttaat agcgtacttc 26280

tttttcttgc tttcgtggta ttcttgctag ttacactagc catccttact gcgcttcgat 26340

tgtgtgcgta ctgctgcaat attgttaacg tgagtcttgt aaaaccttct ttttacgttt 26400

actctcgtgt taaaaatctg aattcttcta gagttcctga tcttctggtc taaacgaact 26460

aaatattata ttagtttttc tgtttggaac tttaatttta gccatggcag attccaacgg 26520

tactattacc gttgaagagc ttaaaaagct ccttgaacaa tggaacctag taataggttt 26580

cctattcctt acatggattt gtcttctaca atttgcctat gccaacagga ataggttttt 26640

gtatataatt aagttaattt tcctctggct gttatggcca gtaactttag cttgttttgt 26700

gcttgctgct gtttacagaa taaattggat caccggtgga attgctatcg caatggcttg 26760

tcttgtaggc ttgatgtggc tcagctactt cattgcttct ttcagactgt ttgcgcgtac 26820

gcgttccatg tggtcattca atccagaaac taacattctt ctcaacgtgc cactccatgg 26880

cactattctg accagaccgc ttctagaaag tgaactcgta atcggagctg tgatccttcg 26940

tggacatctt cgtattgctg gacaccatct aggacgctgt gacatcaagg acctgcctaa 27000

agaaatcact gttgctacat cacgaacgct ttcttattac aaattgggag cttcgcagcg 27060

tgtagcaggt gactcaggtt ttgctgcata cagtcgctac aggattggca actataaatt 27120

aaacacagac cattccagta gcagtgacaa tattgctttg cttgtacagt aagtgacaac 27180

agatgtttca tctcgttgac tttcaggtta ctatagcaga gatattacta attattatga 27240

ggacttttaa agtttccatt tggaatcttg attacatcat aaacctcata attaaaaatt 27300

tatctaagtc actaactgag aataaatatt ctcaattaga tgaagagcaa ccaatggaga 27360

ttgattaaac gaacatgaaa attattcttt tcttggcact gataacactc gctacttgtg 27420

agctttatca ctaccaagag tgtgttagag gtacaacagt acttttaaaa gaaccttgct 27480

cttctggaac atacgagggc aattcaccat ttcatcctct agctgataac aaatttgcac 27540

tgacttgctt tagcactcaa tttgcttttg cttgtcctga cggcgtaaaa cacgtctatc 27600

agttacgtgc cagatcagtt tcacctaaac tgttcatcag acaagaggaa gttcaagaac 27660

tttactctcc aatttttctt attgttgcgg caatagtgtt tataacactt tgcttcacac 27720

tcaaaagaaa gacagaatga ttgaactttc attaattgac ttctatttgt gctttttagc 27780

ctttctgcta ttccttgttt taattatgct tattatcttt tggttctcac ttgaactgca 27840

agatcataat gaaacttgtc acgcctaaac gaacatgaaa tttcttgttt tcttaggaat 27900

catcacaact gtagctgcat ttcaccaaga atgtagttta cagtcatgta cttaacatca 27960

accatatgta gttgatgacc cgtgtcctat tcacttctat tctaaatggt atattagagt 28020

aggagctata aaatcagcac ctttaattga attgtgcgtg gatgaggctg gttctaaatc 28080

acccattcag tgcatcgata tcggtaatta tacagtttcc tgtttacctt ttacaattaa 28140

ttgccaggaa cctaaattgg gtagtcttgt agtgcgttgt tcgttctatg aagacttttt 28200

agagtatcat gacgttcgtg ttgttttaga tttcatctaa acgaacaaac taaatgtctc 28260

taaatggacc ccaaaatcag cgaaatgcac cccgcattac gtttggtgga ccctcagatt 28320

caactggcag taaccagaat ggagaacgca gtggggcgcg atcaaaacaa cgtcggcccc 28380

aaggtttacc caataatact gcgtcttggt tcaccgctct cactcaacat ggcaaggaag 28440

accttaaatt ccctcgagga caaggcgttc caattaacac caatagcagt ccagatgacc 28500

aaattggcta ctaccgaaga gctaccagac gaattcgtgg tggtgacggt aaaatgaaag 28560

atctcagtcc aagatggtat ttctactacc taggaactgg gccagaagct ggacttccct 28620

atggtgctaa caaagacggc atcatatggg ttgcaactga gggagccttg aatacaccaa 28680

aagatcacat tggcacccgc aatcctgcta acaatgctgc aatcgtgcta caacttcctc 28740

aaggaacaac attgccaaaa ggcttctacg cagaagggag cagaggcggc agtcaagcct 28800

cttctcgttc ctcatcacgt agtcgcaaca gttcaagaaa ttcaactcca ggcagcagta 28860

aacgaacttc tcctgctaga atggctggca atggcggtga tgctgctctt gctttgctgc 28920

tgcttgacag attgaaccag cttgagagca aaatgtttgg taaaggccaa caacaacaag 28980

gccaaactgt cactaagaaa tctgctgctg aggcttctaa gaagcctcgg caaaaacgta 29040

ctgccactaa agcatacaat gtaacacaag ctttcggcag acgtggtcca gaacaaaccc 29100

aaggaaattt tggggaccag gaactaatca gacaaggaac tgattacaaa cattggccgc 29160

aaattgcaca atttgccccc agcgcttcag cgttcttcgg aatgtcgcgc attggcatgg 29220

aagtcacacc ttcgggaacg tggttgacct acacaggtgc catcaaattg gatgacaaag 29280

atccaaattt caaagatcaa gtcattttgc tgaataagca tattgacgca tacaaaacat 29340

tcccaccaac agagcctaaa aaggacaaaa agaagaaggc tgatgaaact caagccttac 29400

cgcagagaca gaagaaacag caaactgtga ctcttcttcc tgctgcagat ttggatgatt 29460

tctccaaaca attgcaacaa tccatgagca gtgctgactc aactcaggcc taaactcatg 29520

cagaccacac aaggcagatg ggctatataa acgttttcgc ttttccgttt acgatatata 29580

gtctactctt gtgcagaatg aattctcgta actacatagc acaagtagat gtagttaact 29640

ttaatctcac atagcaatct ttaatcagtg tgtaacatta gggaggactt gaaagagcca 29700

ccacattttc accgaggcca cgcggagtac gatcgagtgt acagtgaaca atgctaggga 29760

gagctgccta tatggaagag ccctaatgtg taaaattaat tttagtagtg ctatccccat 29820

gtgattttaa tagcttctta ggagaatgnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 29880

nnn 29883

<210> 23

<211> 1270

<212> PRT

<213> SARS-CoV2

<400> 23

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val

1 5 10 15

Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe

20 25 30

Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu

35 40 45

His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp

50 55 60

Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro

65 70 75 80

Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser

85 90 95

Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr

100 105 110

Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val

115 120 125

Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys

130 135 140

Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala

145 150 155 160

Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu

165 170 175

Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys

180 185 190

Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn

195 200 205

Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val

210 215 220

Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala

225 230 235 240

Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr

245 250 255

Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe

260 265 270

Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys

275 280 285

Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr

290 295 300

Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr

305 310 315 320

Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly

325 330 335

Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg

340 345 350

Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser

355 360 365

Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu

370 375 380

Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg

385 390 395 400

Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala

405 410 415

Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala

420 425 430

Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr

435 440 445

Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp

450 455 460

Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val

465 470 475 480

Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro

485 490 495

Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe

500 505 510

Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr

515 520 525

Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr

530 535 540

Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln

545 550 555 560

Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg Asp Pro

565 570 575

Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val

580 585 590

Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu

595 600 605

Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp

610 615 620

Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe

625 630 635 640

Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser

645 650 655

Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln

660 665 670

Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser

675 680 685

Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr

690 695 700

Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser Val Thr

705 710 715 720

Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr

725 730 735

Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln

740 745 750

Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala

755 760 765

Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln

770 775 780

Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser

785 790 795 800

Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu

805 810 815

Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys

820 825 830

Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys

835 840 845

Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp

850 855 860

Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr

865 870 875 880

Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala

885 890 895

Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val

900 905 910

Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile

915 920 925

Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys

930 935 940

Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val

945 950 955 960

Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp

965 970 975

Ile Leu Ala Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg

980 985 990

Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln

995 1000 1005

Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu Ala Ala

1010 1015 1020

Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val Asp

1025 1030 1035

Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala

1040 1045 1050

Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln

1055 1060 1065

Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys

1070 1075 1080

Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His

1085 1090 1095

Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr

1100 1105 1110

Thr His Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly

1115 1120 1125

Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp

1130 1135 1140

Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser

1145 1150 1155

Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val

1160 1165 1170

Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu Val Ala Lys

1175 1180 1185

Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu Gly Lys Tyr

1190 1195 1200

Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu Gly Phe Ile

1205 1210 1215

Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met Leu Cys Cys

1220 1225 1230

Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys Ser Cys Gly

1235 1240 1245

Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val Leu Lys

1250 1255 1260

Gly Val Lys Leu His Tyr Thr

1265 1270

<210> 24

<211> 29832

<212> DNA

<213> SARS-CoV2

<400> 24

aaggtttata ccttcccagg taacaaacca accaactttc gatctcttgt agatctgttc 60

tctaaacgaa ctttaaaatc tgtgtggctg tcactcggct gcatgcttag tgcactcacg 120

cagtataatt aataactaat tactgtcgtt gacaggacac gagtaactcg tctatcttct 180

gcaggctgct tacggtttcg tccgtgttgc agccgatcat cagcacatct aggttttgtc 240

cgggtgtgac cgaaaggtaa gatggagagc cttgtccctg gtttcaacga gaaaacacac 300

gtccaactca gtttgcctgt tttacaggtt cgcgacgtgc tcgtacgtgg ctttggagac 360

tccgtggagg aggtcttatc agaggcacgt caacatctta aagatggcac ttgtggctta 420

gtagaagttg aaaaaggcgt tttgcctcaa cttgaacagc cctatgtgtt catcaaacgt 480

tcggatgctc gaactgcacc tcatggtcat gttatggttg agctggtagc agaactcgaa 540

ggcattcagt acggtcgtag tggtgagaca cttggtgtcc ttgtccctca tgtgggcgaa 600

ataccagtgg cttaccgcaa ggttcttctt cgtaagaacg gtaataaagg agctggtggc 660

catagttacg gcgccgatct aaagtcattt gacttaggcg acgagcttgg cactgatcct 720

tatgaagatt ttcaagaaaa ctggaacact aaacatagca gtggtgttac ccgtgaactc 780

atgcgtgagc ttaacggagg ggcatacact cgctatgtcg ataacaactt ctgtggccct 840

gatggctacc ctcttgagtg cattaaagac cttctagcac gtgctggtaa agcttcatgc 900

actttgtccg aacaactgga ctttattgac actaagaggg gtgtatactg ctgccgtgaa 960

catgagcatg aaattgcttg gtacacggaa cgttctgaaa agagctatga attgcagaca 1020

ccttttgaaa ttaaattggc aaagaaattt gacatcttca atggggaatg tccaaatttt 1080

gtatttccct taaattccat aatcaagact attcaaccaa gggttgaaaa gaaaaagctt 1140

gatggcttta tgggtagaat tcgatctgtc tatccagttg cgtcaccaaa tgaatgcaac 1200

caaatgtgcc tttcaactct catgaagtgt gatcattgtg gtgaaacttc atggcagacg 1260

ggcgattttg ttaaagccac ttgcgaattt tgtggcactg agaatttgac taaagaaggt 1320

gccactactt gtggttactt accccaaaat gctgttgtta aaatttattg tccagcatgt 1380

cacaattcag aagtaggacc tgagcatagt cttgccgaat accataatga atctggcttg 1440

aaaaccattc ttcgtaaggg tggtcgcact attgcctttg gaggctgtgt gttctcttat 1500

gttggttgcc ataacaagtg tgcctattgg gttccacgtg ctagcgctaa cataggttgt 1560

aaccatacag gtgttgttgg agaaggttcc gaaggtctta atgacaacct tcttgaaata 1620

ctccaaaaag agaaagtcaa catcaatatt gttggtgact ttaaacttaa tgaagagatc 1680

gccattattt tggcatcttt ttctgcttcc acaagtgctt ttgtggaaac tgtgaaaggt 1740

ttggattata aagcattcaa acaaattgtt gaatcctgtg gtaattttaa agttacaaaa 1800

ggaaaagcta aaaaaggtgc ctggaatatt ggtgaacaga aatcaatact gagtcctctt 1860

tatgcatttg catcagaggc tgctcgtgtt gtacgatcaa ttttctcccg cactcttgaa 1920

actgctcaaa attctgtgcg tgttttacag aaggccgcta taacaatact agatggaatt 1980

tcacagtatt cactgagact cattgatgct atgatgttca catctgattt ggctactaac 2040

aatctagttg taatggccta cattacaggt ggtgttgttc agttgacttc gcagtggcta 2100

actaacatct ttggcactgt ttatgaaaaa ctcaaacccg tccttgattg gcttgaagag 2160

aagtttaagg aaggtgtaga gtttcttaga gacggttggg aaattgttaa atttatctca 2220

acctgtgctt gtgaaattgt cggtggacaa attgtcacct gtgcaaagga aattaaggag 2280

agtgttcaga cattctttaa gcttgtaaat aaatttttgg ctttgtgtgc tgactctatc 2340

attattggtg gagctaaact taaagccttg aatttaggtg aaacatttgt cacgcactca 2400

aagggattgt acagaaagtg tgttaaatcc agagaagaaa ctggcctact catgcctcta 2460

aaagccccaa aagaaattat cttcttagag ggagaaacac ttcccacaga agtgttaaca 2520

gaggaagttg tcttgaaaac tggtgattta caaccattag aacaacctac tagtgaagct 2580

gttgaagctc cattggttgg tacaccagtt tgtattaacg ggcttatgtt gctcgaaatc 2640

aaagacacag aaaagtactg tgcccttgca cctaatatga tggtaacaaa caataccttc 2700

acactcaaag gcggtgcacc aacaaaggtt acttttggtg atgacactgt gatagaagtg 2760

caaggttaca agagtgtgaa tatcactttt gaacttgatg aaaggattga taaagtactt 2820

aatgagaagt gctctgccta tacagttgaa ctcggtacag aagtaaatga gttcgcctgt 2880

gttgtggcag atgctgtcat aaaaactttg caaccagtat ctgaattact tacaccactg 2940

ggcattgatt tagatgagtg gagtatggct acatactact tatttgatga gtctggtgag 3000

tttaaattgg cttcacatat gtattgttct ttttaccctc cagatgagga tgaagaagaa 3060

ggtgattgtg aagaagaaga gtttgagcca tcaactcaat atgagtatgg tactgaagat 3120

gattaccaag gtaaaccttt ggaatttggt gccacttctg ctgctcttca acctgaagaa 3180

gagcaagaag aagattggtt agatgatgat agtcaacaaa ctgttggtca acaagacggc 3240

agtgaggaca atcagacaac tactattcaa acaattgttg aggttcaacc tcaattagag 3300

atggaactta caccagttgt tcagactatt gaagtgaata gttttagtgg ttatttaaaa 3360

cttactgaca atgtatacat taaaaatgca gacattgtgg aagaagctaa aaaggtaaaa 3420

ccaacagtgg ttgttaatgc agccaatgtt taccttaaac atggaggagg tgttgcagga 3480

gccttaaata aggctactaa caatgccatg caagttgaat ctgatgatta catagctact 3540

aatggaccac ttaaagtggg tggtagttgt gttttaagcg gacacaatct tgctaaacac 3600

tgtcttcatg ttgtcggccc aaatgttaac aaaggtgaag acattcaact tcttaagagt 3660

gcttatgaaa attttaatca gcacgaagtt ctacttgcac cattattatc agctggtatt 3720

tttggtgctg accctataca ttctttaaga gtttgtgtag atactgttcg cacaaatgtc 3780

tacttagctg tctttgataa aaatctctat gacaaacttg tttcaagctt tttggaaatg 3840

aagagtgaaa agcaagttga acaaaagatc gctgagattc ctaaagagga agttaagcca 3900

tttataactg aaagtaaacc ttcagttgaa cagagaaaac aagatgataa gaaaatcaaa 3960

gcttgtgttg aagaagttac aacaactctg gaagaaacta agttcctcac agaaaacttg 4020

ttactttata ttgacattaa tggcaatctt catccagatt ctgccactct tgttagtgac 4080

attgacatca ctttcttaaa gaaagatgct ccatatatag tgggtgatgt tgttcaagag 4140

ggtgttttaa ctgctgtggt tatacctact aaaaaggctg gtggcactac tgaaatgcta 4200

gcgaaagctt tgagaaaagt gccaacagac aattatataa ccacttaccc gggtcagggt 4260

ttaaatggtt acactgtaga ggaggcaaag acagtgctta aaaagtgtaa aagtgccttt 4320

tacattctac catctattat ctctaatgag aagcaagaaa ttcttggaac tgtttcttgg 4380

aatttgcgag aaatgcttgc acatgcagaa gaaacacgca aattaatgcc tgtctgtgtg 4440

gaaactaaag ccatagtttc aactatacag cgtaaatata agggtattaa aatacaagag 4500

ggtgtggttg attatggtgc tagattttac ttttacacca gtaaaacaac tgtagcgtca 4560

cttatcaaca cacttaacga tctaaatgaa actcttgtta caatgccact tggctatgta 4620

acacatggct taaatttgga agaagctgct cggtatatga gatctctcaa agtgccagct 4680

acagtttctg tttcttcacc tgatgctgtt acagcgtata atggttatct tacttcttct 4740

tctaaaacac ctgaagaaca ttttattgaa accatctcac ttgctggttc ctataaagat 4800

tggtcctatt ctggacaatc tacacaacta ggtatagaat ttcttaagag aggtgataaa 4860

agtgtatatt acactagtaa tcctaccaca ttccacctag atggtgaagt tatcaccttt 4920

gacaatctta agacacttct ttctttgaga gaagtgagga ctattaaggt gtttacaaca 4980

gtagacaaca ttaacctcca cacgcaagtt gtggacatgt caatgacata tggacaacag 5040

tttggtccaa cttatttgga tggagctgat gttactaaaa taaaacctca taattcacat 5100

gaaggtaaaa cattttatgt tttacctaat gatgacactc tacgtgttga ggcttttgag 5160

tactaccaca caactgatcc tagttttctg ggtaggtaca tgtcagcatt aaatcacact 5220

aaaaagtgga aatacccaca agttaatggt ttaacttcta ttaaatgggc agataacaac 5280

tgttatcttg ccactgcatt gttaacactc caacaaatag agttgaagtt taatccacct 5340

gctctacaag atgcttatta cagagcaagg gctggtgaag ctgctaactt ttgtgcactt 5400

atcttagcct actgtaataa gacagtaggt gagttaggtg atgttagaga aacaatgagt 5460

tacttgtttc aacatgccaa tttagattct tgcaaaagag tcttgaacgt ggtgtgtaaa 5520

acttgtggac aacagcagac aacccttaag ggtgtagaag ctgttatgta catgggcaca 5580

ctttcttatg aacaatttaa gaaaggtgtt cagatacctt gtacgtgtgg taaacaagct 5640

acaaaatatc tagtacaaca ggagtcacct tttgttatga tgtcagcacc acctgctcag 5700

tatgaactta agcatggtac atttacttgt gctagtgagt acactggtaa ttaccagtgt 5760

ggtcactata aacatataac ttctaaagaa actttgtatt gcatagacgg tgctttactt 5820

acaaagtcct cagaatacaa aggtcctatt acggatgttt tctacaaaga aaacagttac 5880

acaacaacca taaaaccagt tacttataaa ttggatggtg ttgtttgtac agaaattgac 5940

cctaagttgg acaattatta taagaaagac aattcttatt tcacagagca accaattgat 6000

cttgtaccaa accaaccata tccaaacgca agcttcgata attttaagtt tgtatgtgat 6060

aatatcaaat ttgctgatga tttaaaccag ttaactggtt ataagaaacc tgcttcaaga 6120

gagcttaaag ttacattttt ccctgactta aatggtgatg tggtggctat tgattataaa 6180

cactacacac cctcttttaa gaaaggagct aaattgttac ataaacctat tgtttggcat 6240

gttaacaatg caactaataa agccacgtat aaaccaaata cctggtgtat acgttgtctt 6300

tggagcacaa aaccagttga aacatcaaat tcgtttgatg tactgaagtc agaggacgcg 6360

cagggaatgg ataatcttgt ctgcgaagat ctaaaaccag tctctgaaga agtagtggaa 6420

aatcctacca tacagaaaga cgttcttgag tgtaatgtga aaactaccga agttgtagga 6480

gacattatac ttaaaccagc aaataatagt ttaaaaatta cagaagaggt tggccacaca 6540

gatctaatgg ctgcttatgt agacaattct agtcttacta ttaagaaacc taatgaatta 6600

tctagagtat taggtttgaa aacccttgct actcatggtt tagctgctgt taatagtgtc 6660

ccttgggata ctatagctaa ttatgctaag ccttttctta acaaagttgt tagtacaact 6720

actaacatag ttacacggtg tttaaaccgt gtttgtacta attatatgcc ttatttcttt 6780

actttattgc tacaattgtg tacttttact agaagtacaa attctagaat taaagcatct 6840

atgccgacta ctatagcaaa gaatactgtt aagagtgtcg gtaaattttg tctagaggct 6900

tcatttaatt atttgaagtc acctaatttt tctaaactga taaatattat aatttggttt 6960

ttactattaa gtgtttgcct aggttcttta atctactcaa ccgctgcttt aggtgtttta 7020

atgtctaatt taggcatgcc ttcttactgt actggttaca gagaaggcta tttgaactct 7080

actaatgtca ctattgcaac ctactgtact ggttctatac cttgtagtgt ttgtcttagt 7140

ggtttagatt ctttagacac ctatccttct ttagaaacta tacaaattac catttcatct 7200

tttaaatggg atttaactgc ttttggctta gttgcagagt ggtttttggc atatattctt 7260

ttcactaggt ttttctatgt acttggattg gctgcaatca tgcaattgtt tttcagctat 7320

tttgcagtac attttattag taattcttgg cttatgtggt taataattaa tcttgtacaa 7380

atggccccga tttcagctat ggttagaatg tacatcttct ttgcatcatt ttattatgta 7440

tggaaaagtt atgtgcatgt tgtagacggt tgtaattcat caacttgtat gatgtgttac 7500

aaacgtaata gagcaacaag agtcgaatgt acaactattg ttaatggtgt tagaaggtcc 7560

ttttatgtct atgctaatgg aggtaaaggc ttttgcaaac tacacaattg gaattgtgtt 7620

aattgtgata cattctgtgc tggtagtaca tttattagtg atgaagttgc gagagacttg 7680

tcactacagt ttaaaagacc aataaatcct actgaccagt cttcttacat cgttgatagt 7740

gttacagtga agaatggttc catccatctt tactttgata aagctggtca aaagacttat 7800

gaaagacatt ctctctctca ttttgttaac ttagacaacc tgagagctaa taacactaaa 7860

ggttcattgc ctattaatgt tatagttttt gatggtaaat caaaatgtga agaatcatct 7920

gcaaaatcag cgtctgttta ctacagtcag cttatgtgtc aacctatact gttactagat 7980

caggcattag tgtctgatgt tggtgatagt gcggaagttg cagttaaaat gtttgatgct 8040

tacgttaata cgttttcatc aacttttaac gtaccaatgg aaaaactcaa aacactagtt 8100

gcaactgcag aagctgaact tgcaaagaat gtgtccttag acaatgtctt atctactttt 8160

atttcagcag ctcggcaagg gtttgttgat tcagatgtag aaactaaaga tgttgttgaa 8220

tgtcttaaat tgtcacatca atctgacata gaagttactg gcgatagttg taataactat 8280

atgctcacct ataacaaagt tgaaaacatg acaccccgtg accttggtgc ttgtattgac 8340

tgtagtgcgc gtcatattaa tgcgcaggta gcaaaaagtc acaacattgc tttgatatgg 8400

aacgttaaag atttcatgtc attgtctgaa caactacgaa aacaaatacg tagtgctgct 8460

aaaaagaata acttaccttt taagttgaca tgtgcaacta ctagacaagt tgttaatgtt 8520

gtaacaacaa agatagcact taagggtggt aaaattgtta ataattggtt gaagcagtta 8580

attaaagtta cacttgtgtt cctttttgtt gctgctattt tctatttaat aacacctgtt 8640

catgtcatgt ctaaacatac tgacttttca agtgaaatca taggatacaa ggctattgat 8700

ggtggtgtca ctcgtgacat agcatctaca gatacttgtt ttgctaacaa acatgctgat 8760

tttgacacat ggtttagcca gcgtggtggt agttatacta atgacaaagc ttgcccattg 8820

attgctgcag tcataacaag agaagtgggt tttgtcgtgc ctggtttgcc tggcacgata 8880

ttacgcacaa ctaatggtga ctttttgcat ttcttaccta gagtttttag tgcagttggt 8940

aacatctgtt acacaccatc aaaacttata gagtacactg actttgcaac atcagcttgt 9000

gttttggctg ctgaatgtac aatttttaaa gatgcttctg gtaagccagt accatattgt 9060

tatgatacca atgtactaga aggttctgtt gcttatgaaa gtttacgccc tgacacacgt 9120

tatgtgctca tggatggctc tattattcaa tttcctaaca cctaccttga aggttctgtt 9180

agagtggtaa caacttttga ttctgagtac tgtaggcacg gcacttgtga aagatcagaa 9240

gctggtgttt gtgtatctac tagtggtaga tgggtactta acaatgatta ttacagatct 9300

ttaccaggag ttttctgtgg tgtagatgct gtaaatttac ttactaatat gtttacacca 9360

ctaattcaac ctattggtgc tttggacata tcagcatcta tagtagctgg tggtattgta 9420

gctatcgtag taacatgcct tgcctactat tttatgaggt ttagaagagc ttttggtgaa 9480

tacagtcatg tagttgcctt taatacttta ctattcctta tgtcattcac tgtactctgt 9540

ttaacaccag tttactcatt cttacctggt gtttattctg ttatttactt gtacttgaca 9600

ttttatctta ctaatgatgt ttctttttta gcacatattc agtggatggt tatgttcaca 9660

cctttagtac ctttctggat aacaattgct tatatcattt gtatttccac aaagcatttc 9720

tattggttct ttactaatta cctaaagaga cgtgtagtct ttaatggtgt ttcctttagt 9780

acttttgaag aagctgcgct gtgcaccttt ttgttaaata aagaaatgta tctaaagttg 9840

cgtagtgatg tgctattacc tcttacgcaa tataatagat acttagctct ttataataag 9900

tacaagtatt ttagtggagc aatggataca actagctaca gagaagctgc ttgttgtcat 9960

ctcgcaaagg ctctcaatga cttcagtaac tcaggttctg atgttcttta ccaaccacca 10020

caaacctcta tcacctcagc tgttttgcag agtggtttta gaaaaatggc attcccatct 10080

ggtaaagttg agggttgtat ggtacaagta acttgtggta caactacact taacggtctt 10140

tggcttgatg acgtagttta ctgtccaaga catgtgatct gcacctctga agacatgctt 10200

aaccctaatt atgaagattt actcattcgt aagtctaatc ataatttctt ggtacaggct 10260

ggtaatgttc aactcagggt tattggacat tctatgcaaa attgtgtact taagcttaag 10320

gttgatacag ccaatcctaa gacacctaag tataagtttg ttcgcattca accaggacag 10380

actttttcag tgttagcttg ttacaatggt tcaccatctg gtgtttacca atgtgctatg 10440

aggcccaatt tcactattaa gggttcattc cttaatggtt catgtggtag tgttggtttt 10500

aacatagatt atgactgtgt ctctttttgt tacatgcacc atatggaatt accaactgga 10560

gttcatgctg gcacagactt agaaggtaac ttttatggac cttttgttga caggcaaaca 10620

gcacaagcag ctggtacgga cacaactatt acagttaatg ttttagcttg gttgtacgct 10680

gctgttataa atggagacag gtggtttctc aatcgattta ccacaactct taatgacttt 10740

aaccttgtgg ctatgaagta caattatgaa cctctaacac aagaccatgt tgacatacta 10800

ggacctcttt ctgctcaaac tggaattgcc gttttagata tgtgtgcttc attaaaagaa 10860

ttactgcaaa atggtatgaa tggacgtacc atattgggta gtgctttatt agaagatgaa 10920

tttacacctt ttgatgttgt tagacaatgc tcaggtgtta ctttccaaag tgcagtgaaa 10980

agaacaatca agggtacaca ccactggttg ttactcacaa ttttgacttc acttttagtt 11040

ttagtccaga gtactcaatg gtctttgttc ttttttttgt atgaaaatgc ctttttacct 11100

tttgctatgg gtattattgc tatgtctgct tttgcaatga tgtttgtcaa acataagcat 11160

gcatttctct gtttgttttt gttaccttct cttgccactg tagcttattt taatatggtc 11220

tatatgcctg ctagttgggt gatgcgtatt atgacatggt tggatatggt tgatactagt 11280

ttgtctggtt ttaagctaaa agactgtgtt atgtatgcat cagctgtagt gttactaatc 11340

cttatgacag caagaactgt gtatgatgat ggtgctagga gagtgtggac acttatgaat 11400

gtcttgacac tcgtttataa agtttattat ggtaatgctt tagatcaagc catttccatg 11460

tgggctctta taatctctgt tacttctaac tactcaggtg tagttacaac tgtcatgttt 11520

ttggccaaag gtattgtttt tatgtgtgtt gagtattgcc ctattttctt cataactggt 11580

aatacacttc agtgtataat gctagtttat tgtttcttag gctatttttg tacttgttac 11640

tttggcctct tttgtttact caaccgctac tttagactga ctcttggtgt ttatgattac 11700

ttagtttcta cacaggagtt tagatatatg aattcacagg gactactccc acccaagaat 11760

agcatagatg ccttcaaact caacattaaa ttgttgggtg ttggtggcaa accttgtatc 11820

aaagtagcca ctgtacagtc taaaatgtca gatgtaaagt gcacatcagt agtcttactc 11880

tcagttttgc aacaactcag agtagaatca tcatctaaat tgtgggctca atgtgtccag 11940

ttacacaatg acattctctt agctaaagat actactgaag cctttgaaaa aatggtttca 12000

ctactttctg ttttgctttc catgcagggt gctgtagaca taaacaagct ttgtgaagaa 12060

atgctggaca acagggcaac cttacaagct atagcctcag agtttagttc ccttccatca 12120

tatgcagctt ttgctactgc tcaagaagct tatgagcagg ctgttgctaa tggtgattct 12180

gaagttgttc ttaaaaagtt gaagaagtct ttgaatgtgg ctaaatctga atttgaccgt 12240

gatgcagcca tgcaacgtaa gttggaaaag atggctgatc aagctatgac ccaaatgtat 12300

aaacaggcta gatctgagga caagagggca aaagttacta gtgctatgca gacaatgctt 12360

ttcactatgc ttagaaagtt ggataatgat gcactcaaca acattatcaa caatgcaaga 12420

gatggttgtg ttcccttgaa cataatacct cttacaacag cagccaaatt aatggttgtc 12480

ataccagact ataacacata taaaaatacg tgtgatggta caacatttac ttatgcatca 12540

gcattgtggg aaatccaaca ggttgtagat gcagatagta aaattgttca acttagtgaa 12600

attagtatgg acaattcacc taatttagca tggcctctta ttgtaacagc tttaagggcc 12660

aattctgctg tcaaattaca gaataatgag cttagtcctg ttgcactacg acagatgtct 12720

tgtgctgccg gtactacaca aactgcttgc actgatgaca atgcgttagc ttactacaac 12780

acaacaaagg gaggtaggtt tgtacttgca ctgttatccg atttacagga tttgaaatgg 12840

gctagattcc ctaagagtga tggaactggt actatctata cagaactgga accaccttgt 12900

aggtttgtta cagacacacc taaaggtcct aaagtgaagt atttatactt tattaaagga 12960

ttaaacaacc taaatagagg tatggtactt ggtagtttag ctgccacagt acgtctacaa 13020

gctggtaatg caacagaagt gcctgccaat tcaactgtat tatctttctg tgcttttgct 13080

gtagatgctg ctaaagctta caaagattat ctagctagtg ggggacaacc aatcactaat 13140

tgtgttaaga tgttgtgtac acacactggt actggtcagg caataacagt tacaccggaa 13200

gccaatatgg atcaagaatc ctttggtggt gcatcgtgtt gtctgtactg ccgttgccac 13260

atagatcatc caaatcctaa aggattttgt gacttaaaag gtaagtatgt acaaatacct 13320

acaacttgtg ctaatgaccc tgtgggtttt acacttaaaa acacagtctg taccgtctgc 13380

ggtatgtgga aaggttatgg ctgtagttgt gatcaactcc gcgaacccat gcttcagtca 13440

gctgatgcac aatcgttttt aaacgggttt gcggtgtaag tgcagcccgt cttacaccgt 13500

gcggcacagg cactagtact gatgtcgtat acagggcttt tgacatctac aatgataaag 13560

tagctggttt tgctaaattc ctaaaaacta attgttgtcg cttccaagaa aaggacgaag 13620

atgacaattt aattgattct tactttgtag ttaagagaca cactttctct aactaccaac 13680

atgaagaaac aatttataat ttacttaaag attgtccagc tgttgctaaa catgacttct 13740

ttaagtttag aatagacggt gacatggtac cacatatatc acgtcaacgt cttactaaat 13800

acacaatggc agacctcgtc tatgctttaa ggcattttga tgaaggtaat tgtgacacat 13860

taaaagaaat acttgtcaca tacaattgtt gtgatgatga ttatttcaat aaaaaggact 13920

ggtatgattt tgtagaaaac ccagatatat tacgcgtata cgccaactta ggtgaacgtg 13980

tacgccaagc tttgttaaaa acagtacaat tctgtgatgc catgcgaaat gctggtattg 14040

ttggtgtact gacattagat aatcaagatc tcaatggtaa ctggtatgat ttcggtgatt 14100

tcatacaaac cacgccaggt agtggagttc ctgttgtaga ttcttattat tcattgttaa 14160

tgcctatatt aaccttgacc agggctttaa ctgcagagtc acatgttgac actgacttaa 14220

caaagcctta cattaagtgg gatttgttaa aatatgactt cacggaagag aggttaaaac 14280

tctttgaccg ttattttaaa tattgggatc agacatacca cccaaattgt gttaactgtt 14340

tggatgacag atgcattctg cattgtgcaa actttaatgt tttattctct acagtgttcc 14400

cacttacaag ttttggacca ctagtgagaa aaatatttgt tgatggtgtt ccatttgtag 14460

tttcaactgg ataccacttc agagagctag gtgttgtaca taatcaggat gtaaacttac 14520

atagctctag acttagtttt aaggaattac ttgtgtatgc tgctgaccct gctatgcacg 14580

ctgcttctgg taatctatta ctagataaac gcactacgtg cttttcagta gctgcactta 14640

ctaacaatgt tgcttttcaa actgtcaaac ccggtaattt taacaaagac ttctatgact 14700

ttgctgtgtc taagggtttc tttaaggaag gaagttctgt tgaattaaaa cacttcttct 14760

ttgctcagga tggtaatgct gctatcagcg attatgacta ctatcgttat aatctaccaa 14820

caatgtgtga tatcagacaa ctactatttg tagttgaagt tgttgataag tactttgatt 14880

gttacgatgg tggctgtatt aatgctaacc aagtcatcgt caacaaccta gacaaatcag 14940

ctggttttcc atttaataaa tggggtaagg ctagacttta ttatgattca atgagttatg 15000

aggatcaaga tgcacttttc gcatatacaa aacgtaatgt catccctact ataactcaaa 15060

tgaatcttaa gtatgccatt agtgcaaaga atagagctcg caccgtagct ggtgtctcta 15120

tctgtagtac tatgaccaat agacagtttc atcaaaaatt attgaaatca atagccgcca 15180

ctagaggagc tactgtagta attggaacaa gcaaattcta tggtggttgg cacaacatgt 15240

taaaaactgt ttatagtgat gtagaaaacc ctcaccttat gggttgggat tatcctaaat 15300

gtgatagagc catgcctaac atgcttagaa ttatggcctc acttgttctt gctcgcaaac 15360

atacaacgtg ttgtagcttg tcacaccgtt tctatagatt agctaatgag tgtgctcaag 15420

tattgagtga aatggtcatg tgtggcggtt cactatatgt taaaccaggt ggaacctcat 15480

caggagatgc cacaactgct tatgctaata gtgtttttaa catttgtcaa gctgtcacgg 15540

ccaatgttaa tgcactttta tctactgatg gtaacaaaat tgccgataag tatgtccgca 15600

atttacaaca cagactttat gagtgtctct atagaaatag agatgttgac acagactttg 15660

tgaatgagtt ttacgcatat ttgcgtaaac atttctcaat gatgatactc tctgacgatg 15720

ctgttgtgtg tttcaatagc acttatgcat ctcaaggtct agtggctagc ataaagaact 15780

ttaagtcagt tctttattat caaaacaatg tttttatgtc tgaagcaaaa tgttggactg 15840

agactgacct tactaaagga cctcatgaat tttgctctca acatacaatg ctagttaaac 15900

agggtgatga ttatgtgtac cttccttacc cagatccatc aagaatccta ggggccggct 15960

gttttgtaga tgatatcgta aaaacagatg gtacacttat gattgaacgg ttcgtgtctt 16020

tagctataga tgcttaccca cttactaaac atcctaatca ggagtatgct gatgtctttc 16080

atttgtactt acaatacata agaaagctac atgatgagtt aacaggacac atgttagaca 16140

tgtattctgt tatgcttact aatgataaca cttcaaggta ttgggaacct gagttttatg 16200

aggctatgta cacaccgcat acagtcttac aggctgttgg ggcttgtgtt ctttgcaatt 16260

cacagacttc attaagatgt ggtgcttgca tacgtagacc attcttatgt tgtaaatgct 16320

gttacgacca tgtcatatca acatcacata aattagtctt gtctgttaat ccgtatgttt 16380

gcaatgctct aggttgtgat gtcacagatg tgactcaact ttacttagga ggtatgagct 16440

attattgtaa atcacataaa ccacccatta gttttccatt gtgtgctaat ggacaagttt 16500

ttggtttata taaaaataca tgtgttggta gcgataatgt tactgacttt aatgcaattg 16560

caacatgtga ctggacaaat gctggtgatt acattttagc taacacctgt actgaaagac 16620

tcaagctttt tgcagcagaa acgctcaaag ctactgagga gacatttaaa ctgtcttatg 16680

gtattgctac tgtacgtgaa gtgctgtctg acagagaatt acatctttca tgggaagttg 16740

gtaaacctag accaccactt aaccgaaatt atgtctttac tggttatcgt gtaactaaaa 16800

acagtaaagt acaaatagga gagtacacct ttgaaaaagg tgactatggt gatgctgttg 16860

tttaccgagg tacaacaact tacaaattaa atgttggtga ttattttgtg ctgacatcac 16920

atacagtaat gccattaagt gcacctacac tagtgccaca agagcactat gttagaatta 16980

ctggcttata cccaacactc aatatctcat atgagttttc tagcaatgtt gcaaattatc 17040

aaaaggttgg tatgcaaaag tattctacac tccagggacc acctggtact ggtaagagtc 17100

attttgctat tggcctagct ctctactacc cttctgctcg catagtgtat acagcttgct 17160

ctcatgccgc tgttgatgca ctatgtgaga aggcattaaa atatttgcct atagataaat 17220

gtagtagaat tatacctgca cgtgctcgtg tagagtgttt tgataaattc aaagtgaatt 17280

caacattaga acagtatgtc ttttgtactg taaatgcatt gcctgagacg acagcagata 17340

tagttgtctt tgatgaaatt tcaatggcca caaattatga tttgagtgtt gtcaatgcca 17400

gattacgtgc taagcactat gtgtacattg gcgaccctgc tcaattacct gcaccacgca 17460

cattgctaac taagggcaca ctagaaccag aatatttcaa ttcagtgtgt agacttatga 17520

aaactatagg tccagacatg ttcctcggaa cttgtcggcg ttgtcctgct gaaattgttg 17580

acactgtgag tgctttggtt tatgataata agcttaaagc acataaagac aaatcagctc 17640

aatgctttaa aatgttttat aagggtgtta tcacgcatga tgtttcatct gcaattaaca 17700

ggccacaaat aggcgtggta agagaattcc ttacacgtaa ccctgcttgg agaaaagctg 17760

tctttatttc accttataat tcacagaatg ctgtagcctc aaagattttg ggactaccaa 17820

ctcaaactgt tgattcatca cagggctcag aatatgacta tgtcatattc actcaaacca 17880

ctgaaacagc tcactcttgt aatgtaaaca gatttaatgt tgctattacc agagcaaaag 17940

taggcatact ttgcataatg tctgatagag acctttatga caagttgcaa tttacaagtc 18000

ttgaaattcc acgtaggaat gtggcaactt tacaagctga aaatgtaaca ggactcttta 18060

aagattgtag taaggtaatc actgggttac atcctacaca ggcacctaca cacctcagtg 18120

ttgacactaa attcaaaact gaaggtttat gtgttgacat acctggcata cctaaggaca 18180

tgacctatag aagactcatc tctatgatgg gttttaaaat gaattatcaa gttaatggtt 18240

accctaacat gtttatcacc cgcgaagaag ctataagaca tgtacgtgca tggattggct 18300

tcgatgtcga ggggtgtcat gctactagag aagctgttgg taccaattta cctttacagc 18360

taggtttttc tacaggtgtt aacctagttg ctgtacctac aggttatgtt gatacaccta 18420

ataatacaga tttttccaga gttagtgcta aaccaccgcc tggagatcaa tttaaacacc 18480

tcataccact tatgtacaaa ggacttcctt ggaatgtagt gcgtataaag attgtacaaa 18540

tgttaagtga cacacttaaa aatctctctg acagagtcgt atttgtctta tgggcacatg 18600

gctttgagtt gacatctatg aagtattttg tgaaaatagg acctgagcgc acctgttgtc 18660

tatgtgatag acgtgccaca tgcttttcca ctgcttcaga cacttatgcc tgttggcatc 18720

attctattgg atttgattac gtctataatc cgtttatgat tgatgttcaa caatggggtt 18780

ttacaggtaa cctacaaagc aaccatgatc tgtattgtca agtccatggt aatgcacatg 18840

tagctagttg tgatgcaatc atgactaggt gtctagctgt ccacgagtgc tttgttaagc 18900

gtgttgactg gactattgaa tatcctataa ttggtgatga actgaagatt aatgcggctt 18960

gtagaaaggt tcaacacatg gttgttaaag ctgcattatt agcagacaaa ttcccagttc 19020

ttcacgacat tggtaaccct aaagctatta agtgtgtacc tcaagctgat gtagaatgga 19080

agttctatga tgcacagcct tgtagtgaca aagcttataa aatagaagaa ttattctatt 19140

cttatgccac acattctgac aaattcacag atggtgtatg cctattttgg aattgcaatg 19200

tcgatagata tcctgctaat tccattgttt gtagatttga cactagagtg ctatctaacc 19260

ttaacttgcc tggttgtgat ggtggcagtt tgtatgtaaa taaacatgca ttccacacac 19320

cagcttttga taaaagtgct tttgttaatt taaaacaatt accatttttc tattactctg 19380

acagtccatg tgagtctcat ggaaaacaag tagtgtcaga tatagattat gtaccactaa 19440

agtctgctac gtgtataaca cgttgcaatt taggtggtgc tgtctgtaga catcatgcta 19500

atgagtacag attgtatctc gatgcttata acatgatgat ctcagctggc tttagcttgt 19560

gggtttacaa acaatttgat acttataacc tctggaacac ttttacaaga cttcagagtt 19620

tagaaaatgt ggcttttaat gttgtaaata agggacactt tgatggacaa cagggtgaag 19680

taccagtttc tatcattaat aacactgttt acacaaaagt tgatggtgtt gatgtagaat 19740

tgtttgaaaa taaaacaaca ttacctgtta atgtagcatt tgagctttgg gctaagcgca 19800

acattaaacc agtaccagag gtgaaaatac tcaataattt gggtgtggac attgctgcta 19860

atactgtgat ctgggactac aaaagagatg ctccagcaca tatatctact attggtgttt 19920

gttctatgac tgacatagcc aagaaaccaa ctgaaacgat ttgtgcacca ctcactgtct 19980

tttttgatgg tagagttgat ggtcaagtag acttatttag aaatgcccgt aatggtgttc 20040

ttattacaga aggtagtgtt aaaggtttac aaccatctgt aggtcccaaa caagctagtc 20100

ttaatggagt cacattaatt ggagaagccg taaaaacaca gttcaattat tataagaaag 20160

ttgatggtgt tgtccaacaa ttacctgaaa cttactttac tcagagtaga aatttacaag 20220

aatttaaacc caggagtcaa atggaaattg atttcttaga attagctatg gatgaattca 20280

ttgaacggta taaattagaa ggctatgcct tcgaacatat cgtttatgga gattttagtc 20340

atagtcagtt aggtggttta catctactga ttggactagc taaacgtttt aaggaatcac 20400

cttttgaatt agaagatttt attcctatgg acagtacagt taaaaactat ttcataacag 20460

atgcgcaaac aggttcatct aagtgtgtgt gttctgttat tgatttatta cttgatgatt 20520

ttgttgaaat aataaaatcc caagatttat ctgtagtttc taaggttgtc aaagtgacta 20580

ttgactatac agaaatttca tttatgcttt ggtgtaaaga tggccatgta gaaacatttt 20640

acccaaaatt acaatctagt caagcgtggc aaccgggtgt tgctatgcct aatctttaca 20700

aaatgcaaag aatgctatta gaaaagtgtg accttcaaaa ttatggtgat agtgcaacat 20760

tacctaaagg cataatgatg aatgtcgcaa aatatactca actgtgtcaa tatttaaaca 20820

cattaacatt agctgtaccc tataatatga gagttataca ttttggtgct ggttctgata 20880

aaggagttgc accaggtaca gctgttttaa gacagtggtt gcctacgggt acgctgcttg 20940

tcgattcaga tcttaatgac tttgtctctg atgcagattc aactttgatt ggtgattgtg 21000

caactgtaca tacagctaat aaatgggatc tcattattag tgatatgtac gaccctaaga 21060

ctaaaaatgt tacaaaagaa aatgactcta aagagggttt tttcacttac atttgtgggt 21120

ttatacaaca aaagctagct cttggaggtt ccgtggctat aaagataaca gaacattctt 21180

ggaatgctga tctttataag ctcatgggac acttcgcatg gtggacagcc tttgttacta 21240

atgtgaatgc gtcatcatct gaagcatttt taattggatg taattatctt ggcaaaccac 21300

gcgaacaaat agatggttat gtcatgcatg caaattacat attttggagg aatacaaatc 21360

caattcagtt gtcttcctat tctttatttg acatgagtaa atttcccctt aaattaaggg 21420

gtactgctgt tatgtcttta aaagaaggtc aaatcaatga tatgatttta tctcttctta 21480

gtaaaggtag acttataatt agagaaaaca acagagttgt tatttctagt gatgttcttg 21540

ttaacaacta aacgaacaat gtttgttttt cttgttttat tgccactagt ctctattcag 21600

tgtgttaatc ttacaaccag aactcaatta ccccctgcat acactaattc tttcacacgt 21660

ggtgtttatt accctgacaa agttttcaga tcctcagttt tacattcaac tcaggacttg 21720

ttcttacctt tcttttccaa tgttacttgg ttccatgcta tacatgtctc tgggaccaat 21780

ggtactaaga ggtttgataa ccctgtccta ccatttaatg atggtgttta ttttgcttcc 21840

actgagaagt ctaacataat aagaggctgg atttttggta ctactttaga ttcgaagacc 21900

cagtccctac ttattgttaa taacgctact aatgttgtta ttaaagtctg tgaatttcaa 21960

ttttgtaatg atccattttt gggtgtttat taccacaaaa acaacaaaag ttgtatggaa 22020

agtgagttca gagtttattc tagtgcgaat aattgcactt ttgaatatgt ctctcagcct 22080

tttcttatgg accttgaagg aaaacagggt aatttcaaaa atcttaggga atttgtgttt 22140

aagaatattg atggttattt taaaatatat tctaagcaca cgcctattaa tttagtgcgt 22200

gatctccctc agggtttttc ggctttagaa ccattggtag atttgccaat aggtattaac 22260

atcactaggt ttcaaacttt acttgcttta catagaagtt atttgactcc tggtgattct 22320

tcttcaggtt ggacagctgg tgctgcagct tattatgtgg gttatcttca acctaggact 22380

tttctattaa aatataatga aaatggaacc attacagatg ctgtagactg tgcacttgac 22440

cctctctcag aaacaaagtg tacgttgaaa tccttcactg tagaaaaagg aatctatcaa 22500

acttctaact ttagagtcca accaacagaa tctattgtta gatttcctaa tattacaaac 22560

ttgtgccctt ttggtgaagt ttttaacgcc accagatttg catctgttta tgcttggaac 22620

aggaagagaa tcagcaactg tgttgctgat tattctgtcc tatataattc cgcatcattt 22680

tccactttta agtgttatgg agtgtctcct actaaattaa atgatctctg ctttactaat 22740

gtctatgcag attcatttgt aattagaggt gatgaagtca gacaaatcgc tccagggcaa 22800

actggaaaga ttgctgatta taattataaa ttaccagatg attttacagg ctgcgttata 22860

gcttggaatt ctaacaatct tgattctaag gttggtggta attataatta ccggtataga 22920

ttgtttagga agtctaatct caaacctttt gagagagata tttcaactga aatctatcag 22980

gccggtagca caccttgtaa tggtgttgaa ggttttaatt gttactttcc tttacaatca 23040

tatggtttcc aacccactaa tggtgttggt taccaaccat acagagtagt agtactttct 23100

tttgaacttc tacatgcacc agcaactgtt tgtggaccta aaaagtctac taatttggtt 23160

aaaaacaaat gtgtcaattt caacttcaat ggtttaacag gcacaggtgt tcttactgag 23220

tctaacaaaa agtttctgcc tttccaacaa tttggcagag acattgctga cactactgat 23280

gctgtccgtg atccacagac acttgagatt cttgacatta caccatgttc ttttggtggt 23340

gtcagtgtta taacaccagg aacaaatact tctaaccagg ttgctgttct ttatcagggt 23400

gttaactgca cagaagtccc tgttgctatt catgcagatc aacttactcc tacttggcgt 23460

gtttattcta caggttctaa tgtttttcaa acacgtgcag gctgtttaat aggggctgaa 23520

catgtcaaca actcatatga gtgtgacata cccattggtg caggtatatg cgctagttat 23580

cagactcaga ctaattctcc tcggcgggca cgtagtgtag ctagtcaatc catcattgcc 23640

tacactatgt cacttggtgc agaaaattca gttgcttact ctaataactc tattgccata 23700

cccacaaatt ttactattag tgttaccaca gaaattctac cagtgtctat gaccaagaca 23760

tcagtagatt gtacaatgta catttgtggt gattcaactg aatgcagcaa tcttttgttg 23820

caatatggca gtttttgtac acaattaaac cgtgctttaa ctggaatagc tgttgaacaa 23880

gacaaaaaca cccaagaagt ttttgcacaa gtcaaacaaa tttacaaaac accaccaatt 23940

aaagattttg gtggttttaa tttttcacaa atattaccag atccatcaaa accaagcaag 24000

aggtcattta ttgaagatct acttttcaac aaagtgacac ttgcagatgc tggcttcatc 24060

aaacaatatg gtgattgcct tggtgatatt gctgctagag acctcatttg tgcacaaaag 24120

tttaacggcc ttactgtttt gccacctttg ctcacagatg aaatgattgc tcaatacact 24180

tctgcactgt tagcgggtac aatcacttct ggttggacct ttggtgcagg tgctgcatta 24240

caaataccat ttgctatgca aatggcttat aggtttaatg gtattggagt tacacagaat 24300

gttctctatg agaaccaaaa attgattgcc aaccaattta atagtgctat tggcaaaatt 24360

caagactcac tttcttccac agcaagtgca cttggaaaac ttcaagatgt ggtcaaccaa 24420

aatgcacaag ctttaaacac gcttgttaaa caacttagct ccaattttgg tgcaatttca 24480

agtgttttaa atgatatcct ttcacgtctt gacaaagttg aggctgaagt gcaaattgat 24540

aggttgatca caggcagact tcaaagtttg cagacatatg tgactcaaca attaattaga 24600

gctgcagaaa tcagagcttc tgctaatctt gctgctacta aaatgtcaga gtgtgtactt 24660

ggacaatcaa aaagagttga tttttgtgga aagggctatc atcttatgtc cttccctcag 24720

tcagcacctc atggtgtagt cttcttgcat gtgacttatg tccctgcaca agaaaagaac 24780

ttcacaactg ctcctgccat ttgtcatgat ggaaaagcac actttcctcg tgaaggtgtc 24840

tttgtttcaa atggcacaca ctggtttgta acacaaagga atttttatga accacaaatc 24900

attactacag acaacacatt tgtgtctggt aactgtgatg ttgtaatagg aattgtcaac 24960

aacacagttt atgatccttt gcaacctgaa ttagactcat tcaaggagga gttagataaa 25020

tattttaaga atcatacatc accagatgtt gatttaggtg acatctctgg cattaatgct 25080

tcagttgtaa acattcaaaa agaaattgac cgcctcaatg aggttgccaa gaatttaaat 25140

gaatctctca tcgatctcca agaacttgga aagtatgagc agtatataaa atggccatgg 25200

tacatttggc taggttttat agctggcttg attgccatag taatggtgac aattatgctt 25260

tgctgtatga ccagttgctg tagttgtctc aagggctgtt gttcttgtgg atcctgctgc 25320

aaatttgatg aagacgactc tgagccagtg ctcaaaggag tcaaattaca ttacacataa 25380

acgaacttat ggatttgttt atgagaatct tcacaattgg aactgtaact ttgaagcaag 25440

gtgaaatcaa ggatgctact ccttcagatt ttgttcgcgc tactgcaacg ataccgatac 25500

aagcctcact ccctttcgga tggcttattg ttggcgttgc acttcttgct gtttttcata 25560

gcgcttccaa aatcataacc ctcaaaaaga gatggcaact agcactctcc aagggtgttc 25620

actttgtttg caacttgctg ttgttgtttg taacagttta ctcacacctt ttgctcgttg 25680

ctgctggcct tgaagcccct tttctctatc tttatgcttt agtctacttc ttgcagagta 25740

taaactttgt aagaataata atgaggcttt ggctttgctg gaaatgccgt tccaaaaacc 25800

cattacttta tgatgccaac tattttcttt gctggcatac taattgttac gactattgta 25860

taccttacaa tagtgtaact tcttcaattg tcattacttc aggtgatggc acaacaagtc 25920

ctatttctga acatgactac cagattggtg gttatactga aaaatgggaa tctggagtaa 25980

aagactgtgt tgtattacac agttacttca cttcagacta ttaccagctg tactcaactc 26040

aattgagtac agacactggt gttgaacatg ttaccttctt catctacaat aaaattgttg 26100

atgagcctga agaacatgtc caaattcaca caatcgacgg ttcatccgga gttgttaatc 26160

cagtaatgga accaatttat gatgaaccga cgacgactac tagcgtgcct ttgtaagcac 26220

aagctgatga gtacgaactt atgtactcat tcgtttcgga agagacaggt acgttaatag 26280

ttaatagcgt acttcttttt cttgctttcg tggtattctt gctagttaca ctagccatcc 26340

ttactgcgct tcgattgtgt gcgtactgct gcaatattgt taacgtgagt cttgtaaaac 26400

cttcttttta cgtttactct cgtgttaaaa atctgaattc ttctagagtt cctgatcttc 26460

tggtctaaac gaactaaata ttatattagt ttttctgttt ggaactttaa ttttagccat 26520

ggtagattcc aacggtacta ttaccgttga agagcttaaa aagctccttg aacaatggaa 26580

cctagtaata ggtttcctat tccttacatg gatttgtctt ctacaatttg cctatgccaa 26640

caggaatagg tttttgtata taattaagtt aatttttctc tggctgttat ggccagtaac 26700

tttagcttgt tttgtgcttg ctgctgttta cagaataaat tggatcaccg gtggaattgc 26760

tatcgcaatg gcttgtcttg taggcttgat gtggctcagc tacttcattg cttctttcag 26820

actgtttgcg cgtacgcgtt ccatgtggtc attcaatcca gaaactaaca ttcttctcaa 26880

cgtgccactc catggcacta ttctgaccag accgcttcta gaaagtgaac tcgtaatcgg 26940

agctgtgatc cttcgtggac atcttcgtat tgctggacac catctaggac gctgtgacat 27000

caaggacctg cctaaagaaa tcactgttgc tacatcacga acgctttctt attacaaatt 27060

gggagcttcg cagcgtgtag caggtgactc aggttttgct gcatacagtc gctacaggat 27120

tggcaactat aaattaaaca cagaccattc cagtagcagt gacaatattg ctttgcttgt 27180

acagtaagtg acaacagatg tttcatctcg ttgactttca ggttactata gcagagatat 27240

tactaattat tatgaggact tttaaagttt ccatttggaa tcttgattac atcataaacc 27300

tcataattaa aaatttatct aagtcactaa ctgagaataa atattctcaa ttagatgaag 27360

agcaaccaat ggagattgat taaacgaaca tgaaaattat tcttttcttg gcactgataa 27420

cactcgctac ttgtgagctt tatcactacc aagagtgtgt tagaggtaca acagtacttt 27480

taaaagaacc ttgctcttct ggaacatacg agggcaattc accatttcat cctctagctg 27540

ataacaaatt tgcactgact tgctttagca ctcaatttgc ttttgcttgt cctgacggcg 27600

taaaacacgt ctatcagtta cgtgccagat cagtttcacc taaactgttc atcagacaag 27660

aggaagttca agaactttac tctccaattt ttcttattgt tgcggcaata gtgtttataa 27720

cactttgctt cacactcaaa agaaagacag aatgattgaa ctttcattaa ttgacttcta 27780

tttgtgcttt ttagcctttc tgctattcct tgttttaatt atgcttatta tcttttggtt 27840

ctcacttgaa ctgcaagatc ataatgaaac ttgtcacgcc taaacgaaca tgaaatttct 27900

tgttttctta ggaatcatca caactgtagc tgcatttcac caagaatgta gtttacagtc 27960

atgtactcaa catcaaccat atgtagttga tgacccgtgt cctattcact tctattctaa 28020

atggtatatt agagtaggag ctagaaaatc agcaccttta attgaattgt gcgtggatga 28080

ggctggttct aaatcaccca ttcagtacat cgatatcggt aattatacag tttcctgttt 28140

accttttaca attaattgcc aggaacctaa attgggtagt cttgtagtgc gttgttcgtt 28200

ctatgaagac tttttagagt atcatgacgt tcgtgttgtt ttagatttca tctaaacgaa 28260

caaactataa tgtctgataa tggaccccaa aatcagcgaa atgcaccccg cattacgttt 28320

ggtggaccct cagattcaac tggcagtaac cagaatggag aacgcagtgg ggcgcgatca 28380

aaacaacgtc ggccccaagg tttacccaat aatactgcgt cttggttcac cgctctcact 28440

caacatggca aggaagacct taaattccct cgaggacaag gcgttccaat taacaccaat 28500

agcagtccag atgaccaaat tggctactac cgaagagcta ccagacgaat tcgtggtggt 28560

gacggtaaaa tgaaagatct cagtccaaga tggtatttct actacctagg aactgggcca 28620

gaagctggac ttccctatgg tgctaacaaa gacggcatca tatgggttgc aactgaggga 28680

gccttgaata caccaaaaga tcacattggc acccgcaatc ctgctaacaa tgctgcaatc 28740

gtgctacaac ttcctcaagg aacaacattg ccaaaaggct tctacgcaga agggagcaga 28800

ggcggcagtc aagcctcttc tcgttcctca tcacgtagtc gcaacagttc aagaaattca 28860

actccaggca gcagtagggg aatttctcct gctagaatgg ctggcaatgg cggtgatgct 28920

gctcttgctt tgctgctgct tgacagattg aaccagcttg agagcaaaat gtctggtaaa 28980

ggccaacaac aacaaggcca aactgtcact aagaaatctg ctgctgaggc ttctaagaag 29040

cctcggcaaa aacgtactgc cactaaagca tacaatgtaa cacaagcttt cggcagacgt 29100

ggtccagaac aaacccaagg aaattttggg gaccaggaac taatcagaca aggaactgat 29160

tacaaacatt ggccgcaaat tgcacaattt gcccccagcg cttcagcgtt cttcggaatg 29220

tcgcgcattg gcatggaagt cacaccttcg ggaacgtggt tgacctacac aggtgccatc 29280

aaattggatg acaaagatcc aaatttcaaa gatcaagtca ttttgctgaa taagcatatt 29340

gacgcataca aaacatttcc accaacagag cctaaaaagg acaaaaagaa gaaggctgat 29400

gaaactcaag ccttaccgca gagacagaag aaacagcaaa ctgtgactct tcttcctgct 29460

gcagatttgg atgatttctc caaacaattg caacaatcca tgagcagtgc tgactcaact 29520

caggcctaaa ctcatgcaga ccacacaagg cagatgggct atataaacgt tttcgctttt 29580

ccgtttacga tatatagtct actcttgtgc agaatgaatt ctcgtaacta catagcacaa 29640

gtagatgtag ttaactttaa tctcacatag caatctttaa tcagtgtgta acattaggga 29700

ggacttgaaa gagccaccac attttcaccg aggccacgcg gagtacgatc gagtgtacag 29760

tgaacaatgc tagggagagc tgcctatatg gaagagccct aatgtgtaaa attaatttta 29820

gtagtgctat cc 29832

<210> 25

<211> 1273

<212> PRT

<213> SARS-CoV2

<400> 25

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ile Gln Cys Val

1 5 10 15

Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe

20 25 30

Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu

35 40 45

His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp

50 55 60

Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp

65 70 75 80

Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu

85 90 95

Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser

100 105 110

Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile

115 120 125

Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr

130 135 140

Tyr His Lys Asn Asn Lys Ser Cys Met Glu Ser Glu Phe Arg Val Tyr

145 150 155 160

Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu

165 170 175

Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe

180 185 190

Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr

195 200 205

Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu

210 215 220

Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr

225 230 235 240

Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser

245 250 255

Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro

260 265 270

Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala

275 280 285

Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys

290 295 300

Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val

305 310 315 320

Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys

325 330 335

Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala

340 345 350

Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu

355 360 365

Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro

370 375 380

Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe

385 390 395 400

Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly

405 410 415

Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys

420 425 430

Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn

435 440 445

Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe

450 455 460

Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys

465 470 475 480

Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly

485 490 495

Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val

500 505 510

Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys

515 520 525

Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn

530 535 540

Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu

545 550 555 560

Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val

565 570 575

Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe

580 585 590

Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val

595 600 605

Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile

610 615 620

His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser

625 630 635 640

Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val

645 650 655

Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala

660 665 670

Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala

675 680 685

Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser

690 695 700

Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile

705 710 715 720

Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val

725 730 735

Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu

740 745 750

Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr

755 760 765

Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln

770 775 780

Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe

785 790 795 800

Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser

805 810 815

Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly

820 825 830

Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp

835 840 845

Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu

850 855 860

Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly

865 870 875 880

Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile

885 890 895

Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr

900 905 910

Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn

915 920 925

Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala

930 935 940

Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn

945 950 955 960

Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val

965 970 975

Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln

980 985 990

Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val

995 1000 1005

Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn

1010 1015 1020

Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys

1025 1030 1035

Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro

1040 1045 1050

Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val

1055 1060 1065

Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His

1070 1075 1080

Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn

1085 1090 1095

Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln

1100 1105 1110

Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val

1115 1120 1125

Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro

1130 1135 1140

Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn

1145 1150 1155

His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn

1160 1165 1170

Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu

1175 1180 1185

Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu

1190 1195 1200

Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu

1205 1210 1215

Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met

1220 1225 1230

Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys

1235 1240 1245

Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro

1250 1255 1260

Val Leu Lys Gly Val Lys Leu His Tyr Thr

1265 1270

<210> 26

<211> 29816

<212> DNA

<213> SARS-CoV2

<400> 26

actttcgatc tcttgtagat ctgttctcta aacgaacttt aaaatctgtg tggctgtcac 60

tcggctgcat gcttagtgca ctcacgcagt ataattaata actaattact gtcgttgaca 120

ggacacgagt aactcgtcta tcttctgcag gctgcttacg gtttcgtccg tgttgcagcc 180

gatcatcagc acatctaggt tttgtccggg tgtgaccgaa aggtaagatg gagagccttg 240

tccctggttt caacgagaaa acacacgtcc aactcagttt gcctgtttta caggttcgcg 300

acgtgctcgt acgtggcttt ggagactccg tggaggaggt cttatcagag gcacgtcaac 360

atcttaaaga tggcacttgt ggcttagtag aagttgaaaa aggcgttttg cctcaacttg 420

aacagcccta tgtgttcatc aaacgttcgg atgctcgaac tgcacctcat ggtcatgtta 480

tggttgagct ggtagcagaa ctcgaaggca ttcagtacgg tcgtagtggt gagacacttg 540

gtgtccttgt ccctcatgtg ggcgaaatac cagtggctta ccgcaaggtt cttcttcgta 600

agaacggtaa taaaggagct ggtggccata gttacggcgc cgatctaaag tcatttgact 660

taggcgacga gcttggcact gatccttatg aagattttca agaaaactgg aacactaaac 720

atagcagtgg tgttacccgt gaactcatgc gtgagcttaa cggaggggca tacactcgct 780

atgtcgataa caacttctgt ggccctgatg gctaccctct tgagtgcatt aaagaccttc 840

tagcacgtgc tggtaaagct tcatgcactt tgtccgaaca actggacttt attgacacta 900

agaggggtgt atactgctgc cgtgaacatg agcatgaaat tgcttggtac acggaacgtt 960

ctgaaaagag ctatgaattg cagacacctt ttgaaattaa attggcaaag aaatttgaca 1020

tcttcaatgg ggaatgtcca aattttgtat ttcccttaaa ttccataatc aagactattc 1080

aaccaagggt tgaaaagaaa aagcttgatg gctttatggg tagaattcga tctgtctatc 1140

cagttgcgtc accaaatgaa tgcaaccaaa tgtgcctttc aactctcatg aagtgtgatc 1200

attgtggtga aacttcatgg cagacgggcg attttgttaa agccacttgc gaattttgtg 1260

gcactgagaa tttgactaaa gaaggtgcca ctacttgtgg ttacttaccc caaaatgctg 1320

ttgttaaaat ttattgtcca gcatgtcaca attcagaagt aggacctgag catagtcttg 1380

ccgaatacca taatgaatct ggcttgaaaa ccattcttcg taagggtggt cgcactattg 1440

cctttggagg ctgtgtgttc tcttatgttg gttgccataa caagtgtgcc tattgggttc 1500

cacgtgctag cgctaacata ggttgtaacc atacaggtgt tgttggagaa ggttccgaag 1560

gtcttaatga caaccttctt gaaatactcc aaaaagagaa agtcaacatc aatattgttg 1620

gtgactttaa acttaatgaa gagatcgcca ttattttggc atctttttct gcttccacaa 1680

gtgcttttgt ggaaactgtg aaaggtttgg attataaagc attcaaacaa attgttgaat 1740

cctgtggtaa ttttaaagtt acaaaaggaa aagctaaaaa aggtgcctgg aatattggtg 1800

aacagaaatc aatactgagt cctctttatg catttgcatc agaggctgct cgtgttgtac 1860

gatcaatttt ctcccgcact cttgaaactg ctcaaaattc tgtgcgtgtt ttacagaagg 1920

ccgctataac aatactagat ggaatttcac agtattcact gagactcatt gatgctatga 1980

tgttcacatc tgatttggct actaacaatc tagttgtaat ggcctacatt acaggtggtg 2040

ttgttcagtt gacttcgcag tggctaacta acatctttgg cactgtttat gaaaaactca 2100

aacccgtcct tgattggctt gaagagaagt ttaaggaagg tgtagagttt cttagagacg 2160

gttgggaaat tgttaaattt atctcaacct gtgcttgtga aattgtcggt ggacaaattg 2220

tcacctgtgc aaaggaaatt aaggagagtg ttcagacatt ctttaagctt gtaaataaat 2280

ttttggcttt gtgtgctgac tctatcatta ttggtggagc taaacttaaa gccttgaatt 2340

taggtgaaac atttgttacg cactcaaagg gattgtacag aaagtgtgtt aaatccagag 2400

aagaaactgg cctactcatg cctctaaaag ccccaaaaga aattatcttc ttagagggag 2460

aaacacttcc cacagaagtg ttaacagagg aagttgtctt gaaaactggt gatttacaac 2520

cattagaaca acctactagt gaagctgttg aagctccact ggttggtaca ccagtttgta 2580

ttaacgggct tatgttgctc gaaatcaaag acacagaaaa gtactgtgcc cttgcaccta 2640

atatgatggt aacaaacaat accttcacac tcaaaggcgg tgcaccaaca aaggttactt 2700

ttggtgatga cactgtgata gaagtgcaag gttacaagag tgtgaatatc acttttgaac 2760

ttgatgaaag gattgataaa gtacttaatg agaagtgctc tgcctataca gttgaactcg 2820

gtacagaagt aaatgagttc gcctgtgttg tggcagatgc tgtcataaaa actttgcaac 2880

cagtatctga attacttaca ccactgggca ttgatttaga tgagtggagt atggctacat 2940

actacttatt tgatgagtct ggtgagttta aattggcttc acatatgtat tgttcttttt 3000

accctccaga tgaggatgaa gaagaaggtg attgtgaaga agaagagttt gagccatcaa 3060

ctcaatatga gtatggtact gaagatgatt accaaggtaa acctttggaa tttggtgcca 3120

cttctgctgc tcttcaacct gaagaagagc aagaagaaga ttggttagat gatgatagtc 3180

aacaaactgt tggtcaacaa gacggcagtg aggacaatca gacaactact attcaaacaa 3240

ttgttgaggt tcaacctcaa ttagagatgg aacttacacc agttgttcag actattgaag 3300

tgaatagttt tagtggttat ttaaaactta ctgacaatgt atacattaaa aatgcagaca 3360

ttgtggaaga agctaaaaag gtaaaaccaa cagtggttgt taatgcagcc aatgtttacc 3420

ttaaacatgg aggaggtgtt gcaggagcct taaataaggc tactaacaat gccatgcaag 3480

ttgaatctga tgattacata gctactaatg gaccacttaa agtgggtggt agttgtgttt 3540

taagcggaca caatcttgct aaacactgtc ttcatgttgt cggcccaaat gttaacaaag 3600

gtgaagacat tcaacttctt aagagtgctt atgaaaattt taatcagcac gaagttctac 3660

ttgcaccatt attatcagct ggtatttttg gtgctgaccc tatacattct ttaagagttt 3720

gtgtagatac tgttcgcaca aatgtctact tagctgtctt tgataaaaat ctctatgaca 3780

aacttgtttc aagctttttg gaaatgaaga gtgaaaagca agttgaacaa aagatcgctg 3840

agattcctaa agaggaagtt aagccattta taactgaaag taaaccttca gttgaacaga 3900

gaaaacaaga tgataagaaa atcaaagctt gtgttgaaga agttacaaca actctggaag 3960

aaactaagtt cctcacagaa aacttgttac tttatattga cattaatggc aatcttcatc 4020

cagattctgc cactcttgtt agtgacattg acatcacttt cttaaagaaa gatgctccat 4080

atatagtggg tgatgttgtt caagagggtg ttttaactgc tgtggttata cctactaaaa 4140

aggctggtgg cactactgaa atgctagcga aagctttgag aaaagtgcca acagacaatt 4200

atataaccac ttacccgggt cagggtttaa atggttacac tgtagaggag gcaaagacag 4260

tgcttaaaaa gtgtaaaagt gccttttaca ttctaccatc tattatctct aatgagaagc 4320

aagaaattct tggaactgtt tcttggaatt tgcgagaaat gcttgcacat gcagaagaaa 4380

cacgcaaatt aatgcctgtc tgtgtggaaa ctaaagccat agtttcaact atacagcgta 4440

aatataaggg tattaaaata caagagggtg tggttgatta tggtgctaga ttttactttt 4500

acaccagtaa aacaactgta gcgtcactta tcaacacact taacgatcta aatgaaactc 4560

ttgttacaat gccacttggc tatgtaacac atggcttaaa tttggaagaa gctgctcggt 4620

atatgagatc tctcaaagtg ccagctacag tttctgtttc ttcacctgat gctgttacag 4680

cgtataatgg ttatcttact tcttcttcta aaacacctga agaacatttt attgaaacca 4740

tctcacttgc tggttcctat aaagattggt cctattctgg acaatctaca caactaggta 4800

tagaatttct taagagaggt gataaaagtg tatattacac tagtaatcct accacattcc 4860

acctagatgg tgaagttatc acctttgaca atcttaagac acttctttct ttgagagaag 4920

tgaggactat taaggtgttt acaacagtag acaacattaa cctccacacg caagttgtgg 4980

acatgtcaat gacatatgga caacagtttg gtccaactta tttggatgga gctgatgtta 5040

ctaaaataaa acctcataat tcacatgaag gtaaaacatt ttatgtttta cctaatgatg 5100

acactctacg tgttgaggct tttgagtact accacacaac tgatcctagt tttctgggta 5160

ggtacatgtc agcattaaat cacactaaaa agtggaaata cccacaagtt aatggtttaa 5220

cttctattaa atgggcagat aacaactgtt atcttgccac tgcattgtta acactccaac 5280

aaatagagtt gaagtttaat ccacctgctc tacaagatgc ttattacaga gcaagggctg 5340

gtgaagctgc taacttttgt gcacttatct tagcctactg taataagaca gtaggtgagt 5400

taggtgatgt tagagaaaca atgagttact tgtttcaaca tgccaattta gattcttgca 5460

aaagagtctt gaacgtggtg tgtaaaactt gtggacaaca gcagacaacc cttaagggtg 5520

tagaagctgt tatgtacatg ggcacacttt cttatgaaca atttaagaaa ggtgttcaga 5580

taccttgtac gtgtggtaaa caagctacaa aatatctagt acaacaggag tcaccttttg 5640

ttatgatgtc agcaccacct gctcagtatg aacttaagca tggtacattt acttgtgcta 5700

gtgagtacac tggtaattac cagtgtggtc actataaaca tataacttct aaagaaactt 5760

tgtattgcat agacggtgct ttacttacaa agtcctcaga atacaaaggt cctattacgg 5820

atgttttcta caaagaaaac agttacacaa caaccataaa accagttact tataaattgg 5880

atggtgttgt ttgtacagaa attgacccta agttggacaa ttattataag aaagacaatt 5940

cttatttcac agagcaacca attgatcttg taccaaacca accatatcca aacgcaagct 6000

tcgataattt taagtttgta tgtgataata tcaaatttgc tgatgattta aaccagttaa 6060

ctggttataa gaaacctgct tcaagagagc ttaaagttac atttttccct gacttaaatg 6120

gtgatgtggt ggctattgat tataaacact acacaccctc ttttaagaaa ggagctaaat 6180

tgttacataa acctattgtt tggcatgtta acaatgcaac taataaagcc acgtataaac 6240

caaatacctg gtgtatacgt tgtctttgga gcacaaaacc agttgaaaca tcaaattcgt 6300

ttgatgtact gaagtcagag gacgcgcagg gaatggataa tcttgcctgc gaagatctaa 6360

aaccagtctc tgaagaagta gtggaaaatc ctaccataca gaaagacgtt cttgagtgta 6420

atgtgaaaac taccgaagtt gtaggagaca ttatacttaa accagcaaat aatagtttaa 6480

aaattacaga agaggttggc cacacagatc taatggctgc ttatgtagac aattctagtc 6540

ttactattaa gaaacctaat gaattatcta gagtattagg tttgaaaacc cttgctactc 6600

atggtttagc tgctgttaat agtgtccctt gggatactat agctaattat gctaagcctt 6660

ttcttaacaa agttgttagt acaactacta acatagttac acggtgttta aaccgtgttt 6720

gtactaatta tatgccttat ttctttactt tattgctaca attgtgtact tttactagaa 6780

gtacaaattc tagaattaaa gcatctatgc cgactactat agcaaagaat actgttaaga 6840

gtgtcggtaa attttgtcta gaggcttcat ttaattattt gaagtcacct aatttttcta 6900

aactgataaa tattataatt tggtttttac tattaagtgt ttgcctaggt tctttaatct 6960

actcaaccgc tgctttaggt gttttaatgt ctaatttagg catgccttct tactgtactg 7020

gttacagaga aggctatttg aactctacta atgtcactat tgcaacctac tgtactggtt 7080

ctataccttg tagtgtttgt cttagtggtt tagattcttt agacacctat ccttctttag 7140

aaactataca aattaccatt tcatctttta aatgggattt aactgctttt ggcttagttg 7200

cagagtggtt tttggcatat attcttttca ctaggttttt ctatgtactt ggattggctg 7260

caatcatgca attgtttttc agctattttg cagtacattt tattagtaat tcttggctta 7320

tgtggttaat aattaatctt gtacaaatgg ccccgatttc agctatggtt agaatgtaca 7380

tcttctttgc atcattttat tatgtatgga aaagttatgt gcatgttgta gacggttgta 7440

attcatcaac ttgtatgatg tgttacaaac gtaatagagc aacaagagtc gaatgtacaa 7500

ctattgttaa tggtgttaga aggtcctttt atgtctatgc taatggaggt aaaggctttt 7560

gcaaactaca caattggaat tgtgttaatt gtgatacatt ctgtgctggt agtacattta 7620

ttagtgatga agttgcgaga gacttgtcac tacagtttaa aagaccaata aatcctactg 7680

accagtcttc ttacatcgtt gatagtgtta cagtgaagaa tggttccatc catctttact 7740

ttgataaagc tggtcaaaag acttatgaaa gacattctct ctctcatttt gttaacttag 7800

acaacctgag agctaataac actaaaggtt cattgcctat taatgttata gtttttgatg 7860

gtaaatcaaa atgtgaagaa tcatctgcaa aatcagcgtc tgtttactac agtcagctta 7920

tgtgtcaacc tatactgtta ctagatcagg cattagtgtc tgatgttggt gatagtgcgg 7980

aagttgcagt taaaatgttt gatgcttacg ttaatacgtt ttcatcaact tttaacgtac 8040

caatggaaaa actcaaaaca ctagttgcaa ctgcagaagc tgaacttgca aagaatgtgt 8100

ccttagacaa tgtcttatct acttttattt cagcagctcg gcaagggttt gttgattcag 8160

atgtagaaac taaagatgtt gttgaatgtc ttaaattgtc acatcaatct gacatagaag 8220

ttactggcga tagttgtaat aactatatgc tcacctataa caaagttgaa aacatgacac 8280

cccgtgacct tggtgcttgt attgactgta gtgcgcgtca tattaatgcg caggtagcaa 8340

aaagtcacaa cattgctttg atatggaacg ttaaagattt catgtcattg tctgaacaac 8400

tacgaaaaca aatacgtagt gctgctaaaa agaataactt accttttaag ttgacatgtg 8460

caactactag acaagttgtt aatgttgtaa caacaaagat agcacttaag ggtggtaaaa 8520

ttgttaataa ttggttgaag cagttaatta aagttacact tgtgttcctt tttgttgctg 8580

ctattttcta tttaataaca cctgttcatg tcatgtctaa acatactgac ttttcaagtg 8640

aaatcatagg atacaaggct attgatggtg gtgtcactcg tgacatagca tctacagata 8700

cttgttttgc taacaaacat gctgattttg acacatggtt tagccagcgt ggtggtagtt 8760

atactaatga caaagcttgc ccattgattg ctgcagtcat aacaagagaa gtgggttttg 8820

tcgtgcctgg tttgcctggc acgatattac gcacaactaa tggtgacttt ttgcatttct 8880

tacctagagt ttttagtgca gttggtaata tctgttacac accatcaaaa cttatagagt 8940

acactgactt tgcaacatca gcttgtgttt tggctgctga atgtacaatt tttaaagatg 9000

cttctggtaa gccagtacca tattgttatg ataccaatgt actagaaggt tctgttgctt 9060

atgaaagttt acgccctgac acacgttatg tgctcatgga tggctctatt attcaatttc 9120

ctaacaccta ccttgaaggt tctgttagag tggtaacaac ttttgattct gagtactgta 9180

ggcacggcac ttgtgaaaga tcagaagctg gtgtttgtgt atctactagt ggtagatggg 9240

tacttaacaa tgattattac agatctttac caggagtttt ctgtggtgta gatgctgtaa 9300

atttacttac taatatgttt acaccactaa ttcaacctat tggtgctttg gacatatcag 9360

catctatagt agctggtggt attgtagcta tcgtagtaac atgccttgcc tactatttta 9420

tgaggtttag aagagctttt ggtgaataca gtcatgtagt tgcctttaat actttactat 9480

tccttatgtc attcactgta ctctgtttaa caccagttta ctcattctta cctggtgttt 9540

attctgttat ttacttgtac ttgacatttt atcttactaa tgatgtttct tttttagcac 9600

atattcagtg gatggttatg ttcacacctt tagtaccttt ctggataaca attgcttata 9660

tcatttgtat ttccacaaag catttctatt ggttctttag taattaccta aagagacgtg 9720

tagtctttaa tggtgtttcc tttagtactt ttgaagaagc tgcgctgtgc acctttttgt 9780

taaataaaga aatgtatcta aagttgcgta gtgatgtgct attacctctt acgcaatata 9840

atagatactt agctctttat aataagtaca agtattttag tggagcaatg gatacaacta 9900

gctacagaga agctgcttgt tgtcatctcg caaaggctct caatgacttc agtaactcag 9960

gttctgatgt tctttaccaa ccaccacaaa cctctatcac ctcagctgtt ttgcagagtg 10020

gttttagaaa aatggcattc ccatctggta aagttgaggg ttgtatggta caagtaactt 10080

gtggtacaac tacacttaac ggtctttggc ttgatgacgt agtttactgt ccaagacatg 10140

tgatctgcac ctctgaagac atgcttaacc ctaattatga agatttactc attcgtaagt 10200

ctaatcataa tttcttggta caggctggta atgttcaact cagggttatt ggacattcta 10260

tgcaaaattg tgtacttaag cttaaggttg atacagccaa tcctaagaca cctaagtata 10320

agtttgttcg cattcaacca ggacagactt tttcagtgtt agcttgttac aatggttcac 10380

catctggtgt ttaccaatgt gctatgaggc ccaatttcac tattaagggt tcattcctta 10440

atggttcatg tggtagtgtt ggttttaaca tagattatga ctgtgtctct ttttgttaca 10500

tgcaccatat ggaattacca actggagttc atgctggcac agacttagaa ggtaactttt 10560

atggaccttt tgttgacagg caaacagcac aagcagctgg tacggacaca actattacag 10620

ttaatgtttt agcttggttg tacgctgctg ttataaatgg agacaggtgg tttctcaatc 10680

gatttaccac aactcttaat gactttaacc ttgtggctat gaagtacaat tatgaacctc 10740

taacacaaga ccatgttgac atactaggac ctctttctgc tcaaactgga attgccgttt 10800

tagatatgtg tgcttcatta aaagaattac tgcaaaatgg tatgaatgga cgtaccatat 10860

tgggtagtgc tttattagaa gatgaattta caccttttga tgttgttaga caatgctcag 10920

gtgttacttt ccaaagtgca gtgaaaagaa caatcaaggg tacacaccac tggttgttac 10980

tcacaatttt gacttcactt ttagttttag tccagagtac tcaatggtct ttgttctttt 11040

ttttgtatga aaatgccttt ttaccttttg ctatgggtat tattgctatg tctgcttttg 11100

caatgatgtt tgtcaaacat aagcatgcat ttctctgttt gtttttgtta ccttctcttg 11160

ccactgtagc ttattttaat atggtctata tgcctgctag ttgggtgatg cgtattatga 11220

catggttgga tatggttgat actagtttgt ctggttttaa gctaaaagac tgtgttatgt 11280

atgcatcagc tgtagtgtta ctaatcctta tgacagcaag aactgtgtat gatgatggtg 11340

ctaggagagt gtggacactt atgaatgtct tgacactcgt ttataaagtt tattatggta 11400

atgctttaga tcaagccatt tccatgtggg ctcttataat ctctgttact tctaactact 11460

caggtgtagt tacaactgtc atgtttttgg ccagaggtat tgtttttatg tgtgttgagt 11520

attgccctat tttcttcata actggtaata cacttcagtg tataatgcta gtttattgtt 11580

tcttaggcta tttttgtact tgttactttg gcctcttttg tttactcaac cgctacttta 11640

gactgactct tggtgtttat gattacttag tttctacaca ggagtttaga tatatgaatt 11700

cacagggact actcccaccc aagaatagca tagatgcctt caaactcaac attaaattgt 11760

tgggtgttgg tggcaaacct tgtatcaaag tagccactgt acagtctaaa atgtcagatg 11820

taaagtgcac atcagtagtc ttactctcag ttttgcaaca actcagagta gaatcatcat 11880

ctaaattgtg ggctcaatgt gtccagttac acaatgacat tctcttagct aaagatacta 11940

ctgaagcctt tgaaaaaatg gtttcactac tttctgtttt gctttccatg cagggtgctg 12000

tagacataaa caagctttgt gaagaaatgc tggacaacag ggcaacctta caagctatag 12060

cttcagagtt tagttccctt ccatcatatg cagcttttgc tactgctcaa gaagcttatg 12120

agcaggctgt tgctaatggt gattctgaag ttgttcttaa aaagttgaag aagtctttga 12180

atgtggctaa atctgaattt gaccgtgatg cagccatgca acgtaagttg gaaaagatgg 12240

ctgatcaagc tatgacccaa atgtataaac aggctagatc tgaggacaag agggcaaaag 12300

ttactagtgc tatgcagaca atgcttttca ctatgcttag aaagttggat aatgatgcac 12360

tcaacaacat tatcaacaat gcaagagatg gttgtgttcc cttgaacata atacctctta 12420

caacagcagc caaactaatg gttgtcatac cagactataa cacatataaa aatacgtgtg 12480

atggtacaac atttacttat gcatcagcat tgtgggaaat ccaacaggtt gtagatgcag 12540

atagtaaaat tgttcaactt agtgaaatta gtatggacaa ttcacctaat ttagcatggc 12600

ctcttattgt aacagcttta agggccaatt ctgctgtcaa attacagaat aatgagctta 12660

gtcctgttgc actacgacag atgtcttgtg ctgccggtac tacacaaact gcttgcactg 12720

atgacaatgc gttagcttac tacaacacaa caaagggagg taggtttgta cttgcactgt 12780

tatccgattt acaggatttg aaatgggcta gattccctaa gagtgatgga actggtactg 12840

tctatacaga actggaacca ccttgtaggt ttgttacaga cacacctaaa ggtcctaaag 12900

tgaagtattt atactttatt aaaggattaa acaacctaaa tagaggtatg gtacttggta 12960

gtttagctgc cacagtacgt ctacaagctg gtaatgcaac agaagtgcct gccaattcaa 13020

ctgtattatc tttctgtgct tttgctgtag atgctgctaa agcttacaaa gattatctag 13080

ctagtggggg acaaccaatc actaattgtg ttaagatgtt gtgtacacac actggtactg 13140

gtcaggcaat aacagttaca ccggaagcca atatggatca agaatccttt ggtggtgcat 13200

cgtgttgtct gtactgccgt tgccacatag atcatccaaa tcctaaagga ttttgtgact 13260

taaaaggtaa gtatgtacaa atacctacaa cttgtgctaa tgaccctgtg ggttttacac 13320

ttaaaaacac agtctgtacc gtctgcggta tgtggaaagg ttatggctgt agttgtgatc 13380

aactccgcga acccatgctt cagtcagctg atgcacaatc gtttttaaac gggtttgcgg 13440

tgtaagtgca gcccgtctta caccgtgcgg cacaggcact agtactgatg tcgtatacag 13500

ggcttttgac atctacaatg ataaagtagc tggttttgct aaattcctaa aaactaattg 13560

ttgtcgcttc caagaaaagg acgaagatga caatttaatt gattcttact ttgtagttaa 13620

gagacacact ttctctaact accaacatga agaaacaatt tataatttac ttaaggattg 13680

tccagctgtt gctaaacatg acttctttaa gtttagaata gacggtgaca tggtaccaca 13740

tatatcacgt caacgtctta ctaaatacac aatggcagac ctcgtctatg ctttaaggca 13800

ttttgatgaa ggtaattgtg acacattaaa agaaatactt gtcacataca attgttgtga 13860

tgatgattat ttcaataaaa aggactggta tgattttgta gaaaacccag atatattacg 13920

cgtatacgcc aacttaggtg aacgtgtacg ccaagctttg ttaaaaacag tacaattctg 13980

tgatgccatg cgaaatgctg gtattgttgg tgtactgaca ttagataatc aagatctcaa 14040

tggtaactgg tatgatttcg gtgatttcat acaaaccacg ccaggtagtg gagttcctgt 14100

tgtagattct tattattcat tgttaatgcc tatattaacc ttgaccaggg ctttaactgc 14160

agagtcacat gttgacactg acttaacaaa gccttacatt aagtgggatt tgttaaaata 14220

tgacttcacg gaagagaggt taaaactctt tgaccgttat tttaaatatt gggatcagac 14280

ataccaccca aattgtgtta actgtttgga tgacagatgc attctgcatt gtgcaaactt 14340

taatgtttta ttctctacag tgttcccact tacaagtttt ggaccactag tgagaaaaat 14400

atttgttgat ggtgttccat ttgtagtttc aactggatac cacttcagag agctaggtgt 14460

tgtacataat caggatgtaa acttacatag ctctagactt agttttaagg aattacttgt 14520

gtatgctgct gaccctgcta tgcacgctgc ttctggtaat ctattactag ataaacgcac 14580

tacgtgcttt tcagtagctg cacttactaa caatgttgct tttcaaactg tcaaacccgg 14640

taattttaac aaagacttct atgactttgc tgtgtctaag ggtttcttta aggaaggaag 14700

ttctgttgaa ttaaaacact tcttctttgc tcaggatggt aatgctgcta tcagcgatta 14760

tgactactat cgttataatc taccaacaat gtgtgatatc agacaactac tatttgtagt 14820

tgaagttgtt gataagtact ttgattgtta cgatggtggc tgtattaatg ctaaccaagt 14880

catcgtcaac aacctagaca aatcagctgg ttttccattt aataaatggg gtaaggctag 14940

actttattat gattcaatga gttatgagga tcaagatgca cttttcgcat atacaaaacg 15000

taatgtcatc cctactataa ctcaaatgaa tcttaagtat gccattagtg caaagaatag 15060

agctcgcacc gtagctggtg tctctatctg tagtactatg accaatagac agtttcatca 15120

aaaattattg aaatcaatag ccgccactag aggagctact gtagtaattg gaacaagcaa 15180

attctatggt ggttggcaca acatgttaaa aactgtttat agtgatgtag aaaaccctca 15240

ccttatgggt tgggattatc ctaaatgtga tagagccatg cctaacatgc ttagaattat 15300

ggcctcactt gttcttgctc gcaaacatac aacgtgttgt agcttgtcac accgtttcta 15360

tagattagct aatgagtgtg ctcaagtatt gagtgaaatg gtcatgtgtg gcggttcact 15420

atatgttaaa ccaggtggaa cctcatcagg agatgccaca actgcttatg ctaatagtgt 15480

ttttaacatt tgtcaagctg tcacggccaa tgttaatgca cttttatcta ctgatggtaa 15540

caaaattgcc gataagtatg tccgcaattt acaacacaga ctttatgagt gtctctatag 15600

aaatagagat gttgacacag actttgtgaa tgagttttac gcatatttgc gtaaacattt 15660

ctcaatgatg atactctctg acgatgctgt tgtgtgtttc aatagcactt atgcatctca 15720

aggtctagtg gctagcataa agaactttaa gtcagttctt tattatcaaa acaatgtttt 15780

tatgtctgaa gcaaaatgtt ggactgagac tgaccttact aaaggacctc atgaattttg 15840

ctctcaacat acaatgctag ttaaacaggg tgatgattat gtgtaccttc cttacccaga 15900

tccatcaaga atcctagggg ccggctgttt tgtagatgat atcgtaaaaa cagatggtac 15960

acttatgatt gaacggttcg tgtctttagc tatagatgct tacccactta ctaaacatcc 16020

taatcaggag tatgctgatg tctttcattt gtacttacaa tacataagaa agctacatga 16080

tgagttaaca ggacacatgt tagacatgta ttctgttatg cttactaatg ataacacttc 16140

aaggtattgg gaacctgagt tttatgaggc tatgtacaca ccgcatacag tcttacaggc 16200

tgttggggct tgtgttcttt gcaattcaca gacttcatta agatgtggtg cttgcatacg 16260

tagaccattc ttatgttgta aatgctgtta cgaccatgtc atatcaacat cacataaatt 16320

agtcttgtct gttaatccgt atgtttgcaa tgctccaggt tgtgatgtca cagatgtgac 16380

tcaactttac ttaggaggta tgagctatta ttgtaaatca cataaaccac ccattagttt 16440

tccattgtgt gctaatggac aagtttttgg tttatataaa aatacatgtg ttggtagcga 16500

taatgttact gactttaatg caattgcaac atgtgactgg acaaatgctg gtgattacat 16560

tttagctaac acctgtactg aaagactcaa gctttttgca gcagaaacgc tcaaagctac 16620

tgaggagaca tttaaactgt cttatggtat tgctactgta cgtgaagtgc tgtctgacag 16680

agaattacat ctttcatggg aagttggtaa acctagacca ccacttaacc gaaattatgt 16740

ctttactggt tatcgtgtaa ctaaaaacag taaagtacaa ataggagagt acacctttga 16800

aaaaggtgac tatggtgatg ctgttgttta ccgaggtaca acaacttaca aattaaatgt 16860

tggtgattat tttgtgctga catcacatac agtaatgcca ttaagtgcac ctacactagt 16920

gccacaagag cactatgtta gaattactgg cttataccca acactcaata tctcatatga 16980

gttttctagc aatgttgcaa attatcaaaa ggttggtatg caaaagtatt ctacactcca 17040

gggaccacct ggtactggta agagtcattt tgctattggc ctagctctct actacccttc 17100

tgctcgcata gtgtatacag cttgctctca tgccgctgtt gatgcactat gtgagaaggc 17160

attaaaatat ttgcctatag ataaatgtag tagaattata cctgcacgtg ctcgtgtaga 17220

gtgttttgat aaattcaaag tgaattcaac attagaacag tatgtctttt gtactgtaaa 17280

tgcattgcct gagacgacag cagatatagt tgtctttgat gaaatttcaa tggccacaaa 17340

ttatgatttg agtgttgtca atgccagatt acgtgctaag cactatgtgt acattggcga 17400

ccctgctcaa ttacctgcac cacgcacatt gctaactaag ggcacactag aaccagaata 17460

tttcaattca gtgtgtagac ttatgaaaac tataggtcca gacatgttcc tcggaacttg 17520

tcggcgttgt cctgctgaaa ttgttgacac tgtgagtgct ttggtttatg ataataagct 17580

taaagcacat aaagacaaat cagctcaatg ctttaaaatg ttttataagg gtgttatcac 17640

gcatgatgtt tcatctgcaa ttaacaggcc acaaataggc gtggtaagag aattccttac 17700

acgtaaccct gcttggagaa aagctgtctt tatttcacct tataattcac agaatgctgt 17760

agcctcaaag attttgggac taccaactca aactgttgat tcatcacagg gctcagaata 17820

tgactatgtc atattcactc aaaccactga aacagctcac tcttgtaatg taaacagatt 17880

taatgttgct attaccagag caaaagtagg catactttgc ataatgtctg atagagacct 17940

ttatgacaag ttgcaattta caagtcttga aattccacgt aggaatgtgg caactttaca 18000

agctgaaaat gtaacaggac tctttaaaga ttgtagtaag gtaatcactg ggttacatcc 18060

tacacaggca cctacacacc tcagtgttga cactaaattc aaaactgaag gtttatgtgt 18120

tgacatacct ggcataccta aggacatgac ctatagaaga ctcatctcta tgatgggttt 18180

taaaatgaat tatcaagtta atggttaccc taacatgttt atcacccgcg aagaagctat 18240

aagacatgta cgtgcatgga ttggcttcga tgtcgagggg tgtcatgcta ctagagaagc 18300

tgttggtacc aatttacctt tacagctagg tttttctaca ggtgttaacc tagttgctgt 18360

acctacaggt tatgttgata cacctaataa tacagatttt tccagagtta gtgctaaacc 18420

accgcctgga gatcaattta aacacctcat accacttatg tacaaaggac ttccttggaa 18480

tgtagtgcgt ataaagattg tacaaatgtt aagtgacaca cttaaaaatc tctctgacag 18540

agtcgtattt gtcttatggg cacatggctt tgagttgaca tctatgaagt attttgtgaa 18600

aataggacct gagcgcacct gttgtctatg tgatagacgt gccacatgct tttccactgc 18660

ttcagacact tatgcctgtt ggcatcattc tattggattt gattacgtct ataatccgtt 18720

tatgattgat gttcaacaat ggggttttac aggtaaccta caaagcaacc atgatctgta 18780

ttgtcaagtc catggtaatg cacatgtagc tagttgtgat gcaatcatga ctaggtgtct 18840

agctgtccac gagtgctttg ttaagcgtgt tgactggact attgaatatc ctataattgg 18900

tgatgaactg aagattaatg cggcttgtag aaaggttcaa cacatggttg ttaaagctgc 18960

attattagca gacaaattcc cagttcttca cgacattggt aaccctaaag ctattaagtg 19020

tgtacctcaa gctgatgtag aatggaagtt ctatgatgca cagccttgta gtgacaaagc 19080

ttataaaata gaagaattat tctattctta tgccacacat tctgacaaat tcacagatgg 19140

tgtatgccta ttttggaatt gcaatgtcga tagatatcct gctaattcca ttgtttgtag 19200

atttgacact agagtgctat ctaaccttaa cttgcctggt tgtgatggtg gcagtttgta 19260

tgtaaataaa catgcattcc acacaccagc ttttgataaa agtgcttttg ttaatttaaa 19320

acaattacca tttttctatt actctgacag tccatgtgag tctcatggaa aacaagtagt 19380

gtcagatata gattatgtac cactaaagtc tgctacgtgt ataacacgtt gcaatttagg 19440

tggtgctgtc tgtagacatc atgctaatga gtacagattg tatctcgatg cttataacat 19500

gatgatctca gctggcttta gcttgtgggt ttacaaacaa tttgatactt ataacctctg 19560

gaacactttt acaagacttc agagtttaga aaatgtggct tttaatgttg taaataaggg 19620

acactttgat ggacaacagg gtgaagtacc agtttctatc attaataaca ctgtttacac 19680

aaaagttgat ggtgttgatg tagaattgtt tgaaaataaa acaacattac ctgttaatgt 19740

agcatttgag ctttgggcta agcgcaacat taaaccagta ccagaggtga aaatactcaa 19800

taatttgggt gtggacattg ctgctaatac tgtgatctgg gactacaaaa gagatgctcc 19860

agcacatata tctactattg gtgtttgttc tatgactgac atagccaaga aaccaactga 19920

aacgatttgt gcaccactca ctgtcttttt tgatggtaga gttgatggtc aagtagactt 19980

atttagaaat gcccgtaatg gtgttcttat tacagaaggt agtgttaaag gtttacaacc 20040

atctgtaggt cccaaacaag ctagtcttaa tggagtcaca ttaattggag aagccgtaaa 20100

aacacagttc aattattata agaaagttga tggtgttgtc caacaattac ctgaaactta 20160

ctttactcag agtagaaatt tacaagaatt taaacccagg agtcaaatgg aaattgattt 20220

cttagaatta gctatggatg aattcattga acggtataaa ttagaaggct atgccttcga 20280

acatatcgtt tatggagatt ttagtcatag tcagttaggt ggtttacatc tactgattgg 20340

actagctaaa cgttttaagg aatcaccttt tgaattagaa gattttattc ctatggacag 20400

tacagttaaa aactatttca taacagatgc gcaaacaggt tcatctaagt gtgtgtgttc 20460

tgttattgat ttattacttg atgattttgt tgaaataata aaatcccaag atttatctgt 20520

agtttctaag gttgtcaaag tgactattga ctatacagaa atttcattta tgctttggtg 20580

taaagatggc catgtagaaa cattttaccc aaaattacaa tctagtcaag cgtggcaacc 20640

gggtgttgct atgcctaatc tttacaaaat gcaaagaatg ctattagaaa agtgtgacct 20700

tcaaaattat ggtgatagtg caacattacc taaaggcata atgatgaatg tcgcaaaata 20760

tactcaactg tgtcaatatt taaacacatt aacattagct gtaccctata atatgagagt 20820

tatacatttt ggtgctggtt ctgataaagg agttgcacca ggtacagctg ttttaagaca 20880

gtggttgcct acgggtacgc tgcttgtcga ttcagatctt aatgactttg tctctgatgc 20940

agattcaact ttgattggtg attgtgcaac tgtacataca gctaataaat gggatctcat 21000

tattagtgat atgtacgacc ctaagactaa aaatgttaca aaagaaaatg actctaaaga 21060

gggttttttc acttacattt gtgggtttat acaacaaaag ctagctcttg gaggttccgt 21120

ggctataaag ataacagaac attcttggaa tgctgatctt tataagctca tgggacactt 21180

cgcatggtgg acagcctttg ttactaatgt gaatgcgtca tcatctgaag catttttaat 21240

tggatgtaat tatcttggca aaccacgcga acaaatagat ggttatgtca tgcatgcaaa 21300

ttacatattt tggaggaata caaatccaat tcagttgtct tcctattctt tatttgacat 21360

gagtaaattt ccccttaaat taaggggtac tgctgttatg tctttaaaag aaggtcaaat 21420

caatgatatg attttatctc ttcttagtaa aggtagactt ataattagag aaaacaacag 21480

agttgttatt tctagtgatg ttcttgttaa caactaaacg aacaatgttt gtttttcttg 21540

ttttattgcc actagtctct attcagtgtg ttaatcttac aaccagaact caattacccc 21600

ctgcatacac taattctttc acacgtggtg tttattaccc tgacaaagtt ttcagatcct 21660

cagttttaca ttcaactcag gacttgttct tacctttctt ttccaatgtt acttggttcc 21720

atgctataca tgtctctggg accaatggta ctaagaggtt tgataaccct gtcctaccat 21780

ttaatgatgg tgtttatttt gcttccactg agaagtctaa cataataaga ggctggattt 21840

ttggtactac tttagattcg aagacccagt ccctacttat tgttaataac gctactaatg 21900

ttgttattaa agtctgtgaa tttcaatttt gtaatgatcc atttttgggt gtttattacc 21960

acaaaaacaa caaaagttgt atggaaagtg agttcagagt ttattctagt gcgaataatt 22020

gcacttttga atatgtctct cagccttttc ttatggacct tgaaggaaaa cagggtaatt 22080

tcaaaaatct tagggaattt gtgtttaaga atattgatgg ttattttaaa atatattcta 22140

agcacacgcc tattaattta gtgcgtgatc tccctcaggg tttttcggct ttagaaccat 22200

tggtagattt gccaataggt attaacatca ctaggtttca aactttactt gctttacata 22260

gaagttattt gactcctggt gattcttctt caggttggac agctggtgct gcagcttatt 22320

atgtgggtta tcttcaacct aggacttttc tattaaaata taatgaaaat ggaaccatta 22380

cagatgctgt agactgtgca cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct 22440

tcactgtaga aaaaggaatc tatcaaactt ctaactttag agtccaacca acagaatcta 22500

ttgttagatt tcctaatatt acaaacttgt gcccttttgg tgaagttttt aacgccacca 22560

gatttgcatc tgtttatgct tggaacagga agagaatcag caactgtgtt gctgattatt 22620

ctgtcctata taattccgca tcattttcca cttttaagtg ttatggagtg tctcctacta 22680

aattaaatga tctctgcttt actaatgtct atgcagattc atttgtaatt agaggtgatg 22740

aagtcagaca aatcgctcca gggcaaactg gaaagattgc tgattataat tataaattac 22800

cagatgattt tacaggctgc gttatagctt ggaattctaa caatcttgat tctaaggttg 22860

gtggtaatta taattaccgg tatagattgt ttaggaagtc taatctcaaa ccttttgaga 22920

gagatatttc aactgaaatc tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt 22980

ttaattgtta ctttccttta caatcatatg gtttccaacc cactaatggt gttggttacc 23040

aaccatacag agtagtagta ctttcttttg aacttctaca tgcaccagca actgtttgtg 23100

gacctaaaaa gtctactaat ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt 23160

taacaggcac aggtgttctt actgagtcta acaaaaagtt tctgcctttc caacaatttg 23220

gcagagacat tgctgacact actgatgctg tccgtgatcc acagacactt gagattcttg 23280

acattacacc atgttctttt ggtggtgtca gtgttataac accaggaaca aatacttcta 23340

accaggttgc tgttctttat cagggtgtta actgcacaga agtccctgtt gctattcatg 23400

cagatcaact tactcctact tggcgtgttt attctacagg ttctaatgtt tttcaaacac 23460

gtgcaggctg tttaataggg gctgaacatg tcaacaactc atatgagtgt gacataccca 23520

ttggtgcagg tatatgcgct agttatcaga ctcagactaa ttctcctcgg cgggcacgta 23580

gtgtagctag tcaatccatc attgcctaca ctatgtcact tggtgcagaa aattcagttg 23640

cttactctaa taactctatt gccataccca caaattttac tattagtgtt accacagaaa 23700

ttctaccagt gtctatgacc aagacatcag tagattgtac aatgtacatt tgtggtgatt 23760

caactgaatg cagcaatctt ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg 23820

ctttaactgg aatagctgtt gaacaagaca aaaacaccca agaagttttt gcacaagtca 23880

aacaaattta caaaacacca ccaattaaag attttggtgg ttttaatttt tcacaaatat 23940

taccagatcc atcaaaacca agcaagaggt catttattga agatctactt ttcaacaaag 24000

tgacacttgc agatgctggc ttcatcaaac aatatggtga ttgccttggt gatattgctg 24060

ctagagacct catttgtgca caaaagttta acggccttac tgttttgcca cctttgctca 24120

cagatgaaat gattgctcaa tacacttctg cactgttagc gggtacaatc acttctggtt 24180

ggacctttgg tgcaggtgct gcattacaaa taccatttgc tatgcaaatg gcttataggt 24240

ttaatggtat tggagttaca cagaatgttc tctatgagaa ccaaaaattg attgccaacc 24300

aatttaatag cgctattggc aaaattcaag actcactttc ttccacagca agtgcacttg 24360

gaaaacttca agatgtggtc aaccaaaatg cacaagcttt aaacacgctt gttaaacaac 24420

ttagctccaa ttttggtgca atttcaagtg ttttaaatga tatcctttca cgtcttgaca 24480

aagttgaggc tgaagtgcaa attgataggt tgatcacagg cagacttcaa agtttgcaga 24540

catatgtgac tcaacaatta attagagctg cagaaatcag agcttctgct aatcttgctg 24600

ctactaaaat gtcagagtgt gtacttggac aatcaaaaag agttgatttt tgtggaaagg 24660

gctatcatct tatgtccttc cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga 24720

cttatgtccc tgcacaagaa aagaacttca caactgctcc tgccatttgt catgatggaa 24780

aagcacactt tcctcgtgaa ggtgtctttg tttcaaatgg cacacactgg tttgtaacac 24840

aaaggaattt ttatgaacca caaatcatta ctacagacaa cacatttgtg tctggtaact 24900

gtgatgttgt aataggaatt gtcaacaaca cagtttatga tcctttgcaa cctgaattag 24960

actcattcaa ggaggagtta gataaatatt ttaagaatca tacatcacca gatgttgatt 25020

taggtgacat ctctggcatt aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc 25080

tcaatgaggt tgccaagaat ttaaatgaat ctctcatcga tctccaagaa cttggaaagt 25140

atgagcagta tataaaatgg ccatggtaca tttggctagg ttttatagct ggcttgattg 25200

ccatagtaat ggtgacaatt atgctttgct gtatgaccag ttgctgtagt tgtctcaagg 25260

gctgttgttc ttgtggatcc tgctgcaaat ttgatgaaga cgactctgag ccagtgctca 25320

aaggagtcaa attacattac acataaacga acttatggat ttgtttatga gaatcttcac 25380

aattggaact gtaactttga agcaaggtga aatcaaggat gctactcctt cagattttgt 25440

tcgcgctact gcaacgatac cgatacaagc ctcactccct ttcggatggc ttattgttgg 25500

cgttgcactt cttgctgttt ttcatagcgc ttccaaaatc ataaccctca aaaagagatg 25560

gcaactagca ctctccaagg gtgttcactt tgtttgcaac ttgctgttgt tgtttgtaac 25620

agtttactca caccttttgc tcgttgctgt tggccttgaa gccccttttc tctatcttta 25680

tgctttagtc tacttcttgc agagtataaa ctttgtaaga ataataatga ggctttggct 25740

ttgctggaaa tgccgttcca aaaacccatt actttatgat gccaactatt ttctttgctg 25800

gcatactaat tgttacgact attgtatacc ttacaatagt gtaacttctt caattgtcat 25860

tacttcaggt gatggcacaa caagtcctat ttctgaacat gactaccaga ttggtggtta 25920

tactgaaaaa tgggaatctg gagtaaaaga ctgtgttgta ttacacagtt acttcacttc 25980

agactattac cagctgtact caactcaatt gagtacagac actggtgttg aacatgttac 26040

cttcttcatc tacaataaaa ttgttgatga gcctgaagaa catgtccaaa ttcacacaat 26100

cgacggttca tccggagttg ttaatccagt aatggaacca atttatgatg aaccgacgac 26160

gactactagc gtgcctttgt aagcacaagc tgatgagtac gaacttatgt actcattcgt 26220

ttcggaagag acaggtacgt taatagttaa tagcgtactt ctttttcttg ctttcgtggt 26280

attcttgcta gttacactag ccatccttac tgcgcttcga ttgtgtgcgt actgctgcaa 26340

tattgttaac gtgagtcttg taaaaccttc tttttacgtt tactctcgtg ttaaaaatct 26400

gaattcttct agagttcctg atcttctggt ctaaacgaac taaatattat attagttttt 26460

ctgtttggaa ctttaatttt agccatggca gattccaacg gtactattac cgttgaagag 26520

cttaaaaagc tccttgaaca atggaaccta gtaataggtt tcctattcct tacatggatt 26580

tgtcttctac aatttgccta tgccaacagg aataggtttt tgtatataat taagttaatt 26640

tttctctggc tgttatggcc agtaacttta gcttgttttg tgcttgctgc tgtttacaga 26700

ataaattgga tcaccggtgg aattgctatc gcaatggctt gtcttgtagg cttgatgtgg 26760

ctcagctact tcattgcttc tttcagactg tttgcgcgta cgcgttccat gtggtcattc 26820

aatccagaaa ctaacattct tctcaacgtg ccactccatg gcactattct gaccagaccg 26880

cttctagaaa gtgaactcgt aatcggagct gtgatccttc gtggacatct tcgtattgct 26940

ggacaccatc taggacgctg tgacatcaag gacctgccta aagaaatcac tgttgctaca 27000

tcacgaacgc tttcttatta caaattggga gcttcgcagc gtgtagcagg tgactcaggt 27060

tttgctgcat acagtcgcta caggattggc aactataaat taaacacaga ccattccagt 27120

agcagtgaca atattgcttt gcttgtacag taagtgacaa cagatgtttc atctcgttga 27180

ctttcaggtt actatagcag agatattact aattattatg aggactttta aagtttccat 27240

ttggaatctt gattacatca taaacctcat aattaaaaat ttatctaagt cactaactga 27300

gaataaatat tctcaattag atgaagagca accaatggag attgattaaa cgaacatgaa 27360

aattattctt ttcttggcac tgataacact cgctacttgt gagctttatc actaccaaga 27420

gtgtgttaga ggtacaacag tacttttaaa agaaccttgc tcttctggaa catacgaggg 27480

caattcacca tttcatcctc tagctgataa caaatttgca ctgacttgct ttagcactca 27540

atttgctttt gcttgtcctg acggcgtaaa acacgtctat cagttacgtg ccagatcagt 27600

ttcacctaaa ctgttcatca gacaagagga agttcaagaa ctttactctc caatttttct 27660

tattgttgcg gcaatagtgt ttataacact ttgcttcaca ctcaaaagaa agacagaatg 27720

attgaacttt cattaattga cttctatttg tgctttttag cctttctgct attccttgtt 27780

ttaattatgc ttattatctt ttggttctca cttgaactgc aagatcataa tgaaacttgt 27840

cacgcctaaa ctaacatgaa atttcttgtt ttcttaggaa tcatcacaac tgtagctgca 27900

tttcaccaag aatgtagttt acagtcatgt actcaacatc aaccatatgt agttgatgac 27960

ccgtgtccta ttcacttcta ttctaaatgg tatattagag taggagctag aaaatcagca 28020

cctttaattg aattgtgcgt ggatgaggct ggttctaaat cacccattca gtacatcgat 28080

atcggtaatt atacagtttc ctgtttacct tttacaatta attgccagga acctaaattg 28140

ggtagtcttg tagtgcgttg ttcgttctat gaagactttt tagagtatca tgacgttcgt 28200

gttgttttag atttcatcta aacgaacaaa ctataatgtc tgataatgga ccccaaaatc 28260

agcgaaatgc accccgcatt acgtttggtg gaccctcaga ttcaactggc agtaaccaga 28320

atggagaacg cagtggggcg cgatcaaaac aacgtcggcc ccaaggttta cccaataata 28380

ctgcgtcttg gttcaccgct ctcactcaac atggcaagga agaccttaaa ttccctcgag 28440

gacaaggcgt tccaattaac accaatagca gtccagatga ccaaattggc tactaccgaa 28500

gagctaccag acgaattcgt ggtggtgacg gtaaaatgaa agatctcagt ccaagatggt 28560

atttctacta cctaggaact gggccagaag ctggacttcc ctatggtgct aacaaagacg 28620

gcatcatatg ggttgcaact gagggagcct tgaatacacc aaaagatcac attggcaccc 28680

gcaatcctgc taacaatgct gcaatcgtgc tacaacttcc tcaaggaaca acattgccaa 28740

aaggcttcta cgcagaaggg agcagaggcg gcagtcaagc ctcttctcgt tcctcatcac 28800

gtagtcgcaa cagttcaaga aattcaactc caggcagcag taggggaatt tctcctgcta 28860

gaatggctgg caatggcggt gatgctgctc ttgctttgct gctgcttgac agattgaacc 28920

agcttgagag caaaatgtct ggtaaaggcc aacaacaaca aggccaaact gtcactaaga 28980

aatctgctgc tgaggcttct aagaagcctc ggcaaaaacg tactgccact aaagcataca 29040

atgtaacaca agctttcggc agacgtggtc cagaacaaac ccaaggaaat tttggggacc 29100

aggaactaat cagacaagga actgattaca aacattggcc gcaaattgca caatttgccc 29160

ccagcgcttc agcgttcttc ggaatgtcgc gcattggcat ggaagtcaca ccttcgggaa 29220

cgtggttgac ctacacaggt gccatcaaat tggatgacaa agatccaaat ttcaaagatc 29280

aagtcatttt gctgaataag catattgacg catacaaaac atttccacca acagagccta 29340

aaaaggacaa aaagaagaag gctgatgaaa ctcaagcctt accgcagaga cagaagaaac 29400

agcaaactgt gactcttctt cctgctgcag atttggatga tttctccaaa caattgcaac 29460

aatccatgag cagtgctgac tcaactcagg cctaaactca tgcagaccac acaaggcaga 29520

tgggctatat aaacgttttc gcttttccgt ttacgatata tagtctactc ttgtgcagaa 29580

tgaattctcg taactacata gcacaagtag atgtagttaa ctttaatctc acatagcaat 29640

ctttaatcag tgtgtaacat tagggaggac ttgaaagagc caccacattt tcaccgaggc 29700

cacgcggagt acgatcgagt gtacagtgaa caatgctagg gagagctgcc tatatggaag 29760

agccctaatg tgtaaaatta attttagtag tgctatcccc atgtgatttt aatagc 29816

<210> 27

<211> 1273

<212> PRT

<213> SARS-CoV2

<400> 27

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ile Gln Cys Val

1 5 10 15

Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe

20 25 30

Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu

35 40 45

His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp

50 55 60

Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp

65 70 75 80

Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu

85 90 95

Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser

100 105 110

Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile

115 120 125

Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr

130 135 140

Tyr His Lys Asn Asn Lys Ser Cys Met Glu Ser Glu Phe Arg Val Tyr

145 150 155 160

Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu

165 170 175

Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe

180 185 190

Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr

195 200 205

Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu

210 215 220

Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr

225 230 235 240

Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser

245 250 255

Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro

260 265 270

Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala

275 280 285

Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys

290 295 300

Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val

305 310 315 320

Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys

325 330 335

Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala

340 345 350

Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu

355 360 365

Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro

370 375 380

Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe

385 390 395 400

Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly

405 410 415

Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys

420 425 430

Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn

435 440 445

Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe

450 455 460

Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys

465 470 475 480

Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly

485 490 495

Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val

500 505 510

Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys

515 520 525

Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn

530 535 540

Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu

545 550 555 560

Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val

565 570 575

Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe

580 585 590

Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val

595 600 605

Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile

610 615 620

His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser

625 630 635 640

Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val

645 650 655

Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala

660 665 670

Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala

675 680 685

Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser

690 695 700

Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile

705 710 715 720

Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val

725 730 735

Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu

740 745 750

Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr

755 760 765

Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln

770 775 780

Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe

785 790 795 800

Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser

805 810 815

Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly

820 825 830

Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp

835 840 845

Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu

850 855 860

Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly

865 870 875 880

Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile

885 890 895

Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr

900 905 910

Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn

915 920 925

Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala

930 935 940

Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn

945 950 955 960

Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val

965 970 975

Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln

980 985 990

Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val

995 1000 1005

Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn

1010 1015 1020

Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys

1025 1030 1035

Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro

1040 1045 1050

Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val

1055 1060 1065

Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His

1070 1075 1080

Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn

1085 1090 1095

Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln

1100 1105 1110

Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val

1115 1120 1125

Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro

1130 1135 1140

Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn

1145 1150 1155

His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn

1160 1165 1170

Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu

1175 1180 1185

Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu

1190 1195 1200

Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu

1205 1210 1215

Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met

1220 1225 1230

Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys

1235 1240 1245

Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro

1250 1255 1260

Val Leu Lys Gly Val Lys Leu His Tyr Thr

1265 1270

<210> 28

<211> 419

<212> PRT

<213> SARS-CoV2

<400> 28

Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr

1 5 10 15

Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg

20 25 30

Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn

35 40 45

Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu

50 55 60

Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro

65 70 75 80

Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly

85 90 95

Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr

100 105 110

Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp

115 120 125

Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp

130 135 140

His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln

145 150 155 160

Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser

165 170 175

Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn

180 185 190

Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala

195 200 205

Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu

210 215 220

Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln

225 230 235 240

Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys

245 250 255

Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln

260 265 270

Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp

275 280 285

Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile

290 295 300

Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile

305 310 315 320

Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala

325 330 335

Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu

340 345 350

Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro

355 360 365

Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln

370 375 380

Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu

385 390 395 400

Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser

405 410 415

Thr Gln Ala

<210> 29

<211> 222

<212> PRT

<213> SARS-CoV2

<400> 29

Met Ala Asp Ser Asn Gly Thr Ile Thr Val Glu Glu Leu Lys Lys Leu

1 5 10 15

Leu Glu Gln Trp Asn Leu Val Ile Gly Phe Leu Phe Leu Thr Trp Ile

20 25 30

Cys Leu Leu Gln Phe Ala Tyr Ala Asn Arg Asn Arg Phe Leu Tyr Ile

35 40 45

Ile Lys Leu Ile Phe Leu Trp Leu Leu Trp Pro Val Thr Leu Ala Cys

50 55 60

Phe Val Leu Ala Ala Val Tyr Arg Ile Asn Trp Ile Thr Gly Gly Ile

65 70 75 80

Ala Ile Ala Met Ala Cys Leu Val Gly Leu Met Trp Leu Ser Tyr Phe

85 90 95

Ile Ala Ser Phe Arg Leu Phe Ala Arg Thr Arg Ser Met Trp Ser Phe

100 105 110

Asn Pro Glu Thr Asn Ile Leu Leu Asn Val Pro Leu His Gly Thr Ile

115 120 125

Leu Thr Arg Pro Leu Leu Glu Ser Glu Leu Val Ile Gly Ala Val Ile

130 135 140

Leu Arg Gly His Leu Arg Ile Ala Gly His His Leu Gly Arg Cys Asp

145 150 155 160

Ile Lys Asp Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu

165 170 175

Ser Tyr Tyr Lys Leu Gly Ala Ser Gln Arg Val Ala Gly Asp Ser Gly

180 185 190

Phe Ala Ala Tyr Ser Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr

195 200 205

Asp His Ser Ser Ser Ser Asp Asn Ile Ala Leu Leu Val Gln

210 215 220

Claims (64)

1. A SARS-CoV-2 vaccine comprising beta-propiolactone inactivated SARS-CoV-2 particles, wherein the vaccine is capable of producing neutralizing antibodies against native SARS-CoV-2 particles in a human subject.

2. A SARS-CoV-2 vaccine as claimed in claim 1, wherein the native surface conformation of the SARS-CoV-2 particle is preserved in the vaccine.

3.A SARS-CoV-2 vaccine according to claim 1 or 2, wherein the viral RNA in the inactivated SARS-CoV-2 particle is replication-defective, preferably wherein the viral RNA in the inactivated SARS-CoV-2 particle: (i) is alkylated and/or acylated; (ii) (ii) comprises one or more modified purine (preferably guanine) residues and/or strand breaks; and/or (iii) cross-linked to one or more viral proteins.

4.A SARS-CoV-2 vaccine according to any preceding claim, wherein the SARS-CoV-2 particles are inactivated by beta-propiolactone at a concentration of 300 to 700ppm, more preferably 500ppm, and inactivated at 2 ℃ to 8 ℃ for about 1 to 48 hours, preferably 20 to 28 hours, most preferably 24 hours ± 2 hours (e.g. also ± 1 hour or ± 0.5 hours), and then optionally hydrolysed at 35 ℃ to 39 ℃, preferably about 37 ℃ for 2.5 hours ± 0.5 hours.

5. A SARS-CoV-2 vaccine according to any preceding claim, further comprising Ultraviolet (UV) inactivated SARS-CoV-2 particles.

6. A SARS-CoV-2 vaccine according to any preceding claim, wherein the surface protein in the inactivated SARS-CoV-2 particle comprises reduced modifications compared to the viral RNA in the inactivated SARS-CoV-2 particle, preferably wherein the surface protein comprises a reduced proportion of modified residues compared to the viral RNA in the inactivated SARS-CoV-2 particle; the modification relates to native SARS-CoV-2 particles, preferably wherein the modification comprises alkylated and/or acylated nucleotide or amino acid residues.

7. A SARS-CoV-2 vaccine according to any preceding claim, wherein the inactivated SARS-CoV-2 particle comprises the following native conformation: (i) a spike (S) protein; (ii) a nucleocapsid (N) protein; (iii) a membrane (M) glycoprotein; and/or (iv) envelope (E) proteins; preferably wherein the inactivated SARS-CoV-2 particle comprises a native conformational spike (S) protein.

8. A SARS-CoV-2 vaccine according to any preceding claim, wherein the inactivated SARS-CoV-2 particles comprise one or more beta-propiolactone modified cysteine, methionine and/or histidine residues.

9. A SARS-CoV-2 vaccine according to any preceding claim, wherein the inactivated SARS-CoV-2 particle comprises less than 200, 100, 50, 30, 20, 15, 10, 9, 8, 7 or 6 beta-propiolactone modified amino acid residues; preferably wherein the spike (S) protein of the inactivated SARS-CoV-2 particle comprises less than 100, 50, 30, 20, 15, 10, 9, 8, 7 or 6 beta-propiolactone modified amino acid residues; more preferably wherein the inactivated SARS-CoV-2 particle or spike protein thereof comprises 15 or fewer beta-propiolactone modified amino acid residues; most preferably wherein the inactivated SARS-CoV-2 particle or spike protein thereof comprises 1 to 100, 2 to 50, 3 to 30, 5 to 20, or about 15 beta-propiolactone modified amino acid residues.

10. A SARS-CoV-2 vaccine according to any preceding claim, wherein less than 20%, 15%, 10%, 5% or 4% of the SARS-CoV-2 polypeptides in the particle are beta-propiolactone modified; preferably wherein 0.1-10%, more preferably 1-5%, more preferably 2-8% or about 3-6% of the SARS-CoV-2 polypeptide in the particle comprises at least one beta-propiolactone modification; preferably as detected in the vaccine by mass spectrometry, optionally after digestion or acid hydrolysis with trypsin, chymotrypsin and/or PNGase F enzymes.

11. A SARS-CoV-2 vaccine according to any preceding claim, wherein:

(i) The spike (S) protein of the inactivated SARS-CoV-2 particle comprises a beta-propiolactone modification of one or more of the following residues: 49. 146, 166, 177, 207, 245, 379, 432, 519, 625, 1029, 1032, 1058, 1083, 1088, 1101, 1159, and/or 1271; preferably H49, H146, C166, M177, H207, H245, C432, H519, H625, M1029, H1058, H1083, H1088, H1101, H1159 and/or H1271; or H207, H245, C379, M1029 and/or C1032, for example in SEQ ID NO 3, or the corresponding position in SEQ ID NO 19, 21, 23, 25 or 27; and/or

(ii) The membrane (M) glycoprotein of the inactivated SARS-CoV-2 particle comprises a beta-propiolactone modification of one or more of the following residues: 125. 154, 155, 159, and/or 210; preferably H154, H155, C159 and/or H210, for example as in SEQ ID NO. 29;

(iii) The nucleocapsid (N) protein of the inactivated SARS-CoV-2 particle comprises a β -propiolactone modification at M234, e.g., as in SEQ ID NO: 28.

12. A SARS-CoV-2 vaccine according to any preceding claim, wherein less than 30%, 20%, 10%, 5%, 3% or 1% of one or more, preferably at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or all of the following residues in the inactivated SARS-CoV-2 particle are β -propiolactone modified:

(i) In the peak (S) protein, residues 49, 146, 166, 177, 207, 245, 379, 432, 519, 625, 1029, 1032, 1058, 1083, 1088, 1101, 1159 and/or 1271; preferably H49, H146, C166, M177, H207, H245, C432, H519, H625, M1029, H1058, H1083, H1088, H1101, H1159 and/or H1271; or H207, H245, C379, M1029 and/or C1032; e.g., in SEQ ID NO 3, or in the corresponding position in SEQ ID NO 19, 21, 23, 25 or 27; and/or (ii) residues 125, 154, 155, 159 and/or 210 in a membrane (M) glycoprotein; preferably H154, H155, C159 and/or H210; such as in SEQ ID NO: 29; and/or (iii) M234 of the nucleocapsid (N) protein, for example as in SEQ ID NO: 28.

13.A SARS-CoV-2 vaccine as claimed in any preceding claim, wherein the proportion of β -propiolactone modifying residues at each of the following positions in the inactivated SARS-CoV-2 particle is:

(i) In the spike (S) protein (e.g., SEQ ID NO:3 or the corresponding position in SEQ ID NO:19, 21, 23, 25 or 27):

(a) Residues H49, H146, C166, H207, H519, M1029, H1083, H1088, H1101, H1159 and/or H1271: less than 20%, preferably from 0.01 to 10%, more preferably from 0.1 to 5%; and/or

(b) Residues M177, C432, H625: less than 30%, preferably from 0.1 to 20%, more preferably from 1 to 10%; and/or

(c) Residues H245, H1058: less than 30%, preferably from 0.1 to 20%, more preferably from 5 to 15%;

(ii) In membrane (M) glycoproteins (e.g., SEQ ID NO: 29):

(f) H154: less than 5%, less than 1% or less than 0.1%; and/or

(g) H155: less than 10%, preferably 0.1 to 5%; and/or

(h) C159: less than 5%, less than 1% or less than 0.1%; and/or

(i) H210: less than 20%, preferably 0.1 to 10%; and/or

(iii) In the nucleocapsid (N) protein (e.g., SEQ ID NO: 28):

(j) M234: less than 90%, less than 10%, or less than 0.1%.

14. A SARS-CoV-2 vaccine according to any preceding claim, wherein the infectivity of mammalian cells by the inactivated SARS-CoV-2 particle is reduced by at least 99%, 99.99% or 99.9999% compared to native SARS-CoV-2 particles, or wherein the infectivity of mammalian cells by the inactivated SARS-CoV-2 particle is undetectable.

15. A SARS-CoV-2 vaccine according to any preceding claim, further comprising one or more pharmaceutically acceptable excipients, such as Human Serum Albumin (HSA).

16. A SARS-CoV-2 vaccine according to any preceding claim, further comprising an adjuvant.

17. A SARS-CoV-2 vaccine as claimed in claim 16, wherein the adjuvant comprises aluminium hydroxide or aluminium phosphate.

18. A SARS-CoV-2 vaccine as claimed in claim 17, wherein aluminium hydroxide or aluminium phosphate is the only adjuvant in the vaccine.

19. A SARS-CoV-2 vaccine according to claim 16 or 17, wherein the adjuvant comprises or further comprises a Th1 response-directing adjuvant.

20. A SARS-CoV-2 vaccine according to claim 19, wherein the Th1 response targeting adjuvant comprises 3-O-deacyl-4' -monophosphoryl lipid a (MPL), saponin QS-21, a CpG containing oligonucleotide (CpG ODN), squalene, DL-alpha-tocopherol, a cationic peptide, a deoxynucleotide containing immunostimulatory oligonucleotide molecule (I-ODN) and/or imiquimod.

21. A SARS-CoV-2 vaccine as claimed in claim 16, wherein the adjuvant comprises:

(i) A liposomal formulation comprising 3-O-deacyl-4' -monophosphoryl lipid a (MPL) and saponin QS-21, preferably adjuvant system 01;

(ii) CpG ODN comprising sequence 5 'TGACTGTGAACGTTCGAGAGATGA 3' (SEQ ID NO: 4), preferably CpG 1018;

(iii) Squalene, DL-alpha-tocopherol and polysorbate 80 (preferably adjuvant system 03);

(iv) An oil-in-water emulsion comprising squalene, tween 80 and Span 85, preferably MF59;

(v) Sequence KLKLKLKLL ₅ KLK (SEQ ID NO: 5) and oligo-d (IC) ₁₃ (SEQ ID NO: 6), preferably IC 31; or

(vi) An aluminium salt and optionally a Th1 directing adjuvant.

22. A SARS-CoV-2 vaccine according to any preceding claim, wherein the vaccine is capable of seroconverting a subject administered the SARS-CoV-2 vaccine with a probability of at least 70%.

23. A SARS-CoV-2 vaccine as claimed in claim 22, wherein the SARS-CoV-2 vaccine is capable of seroconverting a subject administered with the SARS-CoV-2 vaccine with a probability of at least 80%, 85%, 90% or 95%.

24. A SARS-CoV-2 vaccine according to any preceding claim, wherein the SARS-CoV-2 particles comprise an RNA sequence (and/or a fragment thereof, optionally comprising modified (preferably alkylated or acylated) nucleotide residues) corresponding to the following DNA sequence: (i) is defined by SEQ ID NO:9; or (ii) has at least 80%, at least 85%, at least 90%, at least 95%, or at least 99% sequence identity to SEQ ID NO 9; preferably wherein the native (non-inactivated) SARS-CoV-2 particles comprising the RNA sequence are capable of encapsulating virulent SARS-CoV-2.

25. A SARS-CoV-2 vaccine according to any preceding claim, wherein the vaccine comprises additional SARS-CoV-2 particles comprising an RNA sequence (and/or a fragment thereof, optionally comprising modified (preferably alkylated or acylated) nucleotide residues) corresponding to the following DNA sequence: (i) is defined by SEQ ID NO:18; or (ii) has at least 80%, at least 85%, at least 90%, at least 95%, or at least 99% sequence identity to SEQ ID NO 18; preferably wherein the native (non-inactivated) SARS-CoV-2 particles comprising the RNA sequence are capable of encapsulating virulent SARS-CoV-2.

26. A SARS-CoV-2 vaccine according to any preceding claim, wherein the vaccine comprises additional SARS-CoV-2 particles comprising an RNA sequence (and/or a fragment thereof, optionally comprising modified (preferably alkylated or acylated) nucleotide residues) corresponding to the following DNA sequence: (i) is defined by SEQ ID NO:22; or (ii) has at least 80%, at least 85%, at least 90%, at least 95%, or at least 99% sequence identity to SEQ ID NO. 22; preferably wherein the native (non-inactivated) SARS-CoV-2 particles comprising the RNA sequence are capable of encapsulating virulent SARS-CoV-2.

27. A SARS-CoV-2 vaccine according to any preceding claim, wherein the vaccine is obtained or obtainable from Vero cells.

28. A SARS-CoV-2 vaccine according to any preceding claim, wherein upon administration to a human subject the vaccine (i) does not induce Antibody Dependent Enhancement (ADE) of SARS-CoV-2 related disease (COVID-19); and/or (ii) does not induce immunopathology in the subject.

29. A method of preventing or treating SARS-CoV-2infection and/or SARS-CoV-2 related disease (COVID-19) in a human subject in need thereof, comprising administering to the subject a prophylactically or therapeutically effective amount of the SARS-CoV-2 vaccine of any preceding claim.

30. The method of claim 29, further comprising administering a prophylactically or therapeutically effective amount of a second dose of SARS-CoV-2 vaccine, preferably wherein the second dose of vaccine is the same formulation as the first dose.

31. The method of claim 29 or 30, wherein the prophylactically or therapeutically effective amount of SARS-CoV-2 vaccine per dose is defined as about 1 to 100 AU/dose, preferably about 2 to 75 AU/dose, preferably about 3 to 60 AU/dose, more preferably about 3 to 55 AU/dose, more preferably about 3 to 53 AU/dose, as assessed by ELISA, even more preferably at about 3 to 40 AU/dose, more preferably at about 10 to 60 AU/dose, 20 to 50 AU/dose, 25 to 45 AU/dose or 30 to 40 AU/dose, such as 35 AU/dose or 40 AU/dose.

32. The method of claim 29 or 30, wherein the prophylactically or therapeutically effective amount per dose of SARS-CoV-2 vaccine is defined as about 0.05 to 50 μ g total protein, about 0.1 to 25 μ g, about 0.25 to 12.5 μ g, preferably about 0.5 to 5 μ g total protein, more preferably at least 2.5 μ g total protein, at least 3.5 μ g total protein or at least 2.5 μ g total protein, even more preferably 2.5 μ g to 25 μ g,3.5 μ g to 10 μ g or 4 μ g to 6 μ g total protein per dose, most preferably about 5 μ g total protein per dose, e.g. as measured by (μ) BCA.

33. The method of claim 29 or 30, wherein the prophylactically or therapeutically effective amount of SARS-CoV-2 vaccine per dose is defined as about 0.025 to 25 μ g S protein, about 0.05 to 12.5 μ g, about 0.125 to 6.25 μ g, preferably about 0.25 to 2.5 μ g S protein, measured by ELISA.

34. The method of claim 30, wherein a second dose of SARS-CoV-2 vaccine is administered about 7 days, about 14 days, about 21 days, or about 28 days after the first dose of SARS-CoV-2 vaccine, preferably wherein the second dose of vaccine is the same formulation as the first dose.

35. The method of any one of claims 28 to 34, wherein administration results in the production of SARS-CoV-2 neutralizing antibodies.

36. A method of making a SARS-CoV-2 vaccine, comprising:

(a) Preparing natural SARS-CoV-2 particle;

(b) Inactivating the native SARS-CoV-2 particles to obtain inactivated SARS-CoV-2 particles;

(c) Incorporating inactivated SARS-CoV-2 particles into a vaccine composition;

wherein the native surface conformation of the SARS-CoV-2 particle is retained in the inactivation step such that the vaccine is capable of producing neutralizing antibodies against the native SARS-CoV-2 particle in a human subject.

37. The method of claim 36, wherein the vaccine composition comprises aluminum hydroxide.

38. The method of claim 37, wherein the SARS-CoV-2 vaccine comprising aluminum hydroxide contains less than 1.25ppb copper.

39. The method of any one of claims 36 to 38, wherein the inactivating step preferentially targets viral RNA in SARS-CoV-2 particles.

40. The method of claim 36 or 39, wherein the inactivating step comprises: (ii) (i) alkylating and/or acylating viral RNA; (ii) Modifying purine (preferably guanine) residues or introducing strand breaks into viral RNA; and/or (iii) cross-linking the viral RNA with one or more viral proteins.

41. The method of any one of claims 36, 39 or 40, wherein the inactivating step comprises treating native SARS-CoV-2 particles with beta-propiolactone.

42. The method of claim 41, wherein the concentration of beta-propiolactone in the inactivation step is from 0.01 to 1 weight percent, preferably from 0.05 to 0.5 weight percent, more preferably about 0.1 weight percent.

43. The method of claim 41 or 42, wherein the native SARS-CoV-2 particles are contacted with beta-propiolactone for at least 5 hours, at least 10 hours, at least 24 hours, or at least 4 days.

44. The method of any one of claims 36 or 39 to 43, wherein the inactivation step is performed at about 0 ℃ to about 25 ℃, preferably about 4 ℃ or about 22 ℃.

45. The method of any of claims 36 or 39-44, wherein the inactivating step comprises treating the native SARS-CoV-2 particles with Ultraviolet (UV) light.

46. The method of any one of claims 36 or 39 to 45, wherein step (a) comprises one or more of the steps of:

(i) Passaging SARS-CoV-2 on Vero cells to produce a medium comprising SARS-CoV-2;

(ii) (ii) harvesting the culture medium of (i);

(iii) (iii) precipitating the harvest medium of (ii) thereby preparing native SARS-CoV-2 particles in the supernatant.

47. The method of claim 46, further comprising concentrating the medium of (ii) prior to step (iii).

48. The method of claim 46 or 47, wherein the precipitating of (iii) comprises contacting the medium of (ii) with protamine sulfate or benzoate enzyme.

49. The method of any one of claims 36 or 39 to 48, further comprising dialyzing the inactivated SARS-CoV-2 particles, thereby producing dialyzed SARS-CoV-2.

50. The method of claim 49, further comprising filtering the dialyzed SARS-CoV-2.

51. The method of any of claims 36 or 39 to 50, wherein the inactivating step comprises contacting a liquid composition comprising native SARS-CoV-2 particles with a chemical virus inactivating agent in a container, mixing the chemical virus inactivating agent and the liquid composition comprising SARS-CoV-2 particles under conditions of laminar flow rather than turbulent flow, and incubating the chemical virus inactivating agent and the liquid composition comprising SARS-CoV-2 particles for a time sufficient to inactivate the viral particles.

52. The method of claim 51, wherein the inactivating step is performed in a flexible bioreactor bag.

53. The method of claim 51 or 52, wherein the inactivation step comprises five or fewer container inversions during inactivation.

54. The method of any one of claims 51-53, wherein mixing of the chemical virus-inactivating agent and the composition comprising native SARS-CoV-2 particles comprises rocking, rotating, orbital rocking, or shaking the container at a speed of no more than 10rpm for no more than 10 minutes during incubation.

55. The method of any one of claims 36 or 39 to 54, further comprising purifying the inactivated SARS-CoV-2 particles by one or more methods selected from (i) batch chromatography and/or (ii) sucrose density gradient centrifugation.

56. The method of any one of claims 36 or 39 to 55, wherein step (c) comprises combining the inactivated SARS-CoV-2 particles with an adjuvant.

57. The method of claim 56, wherein said adjuvant comprises a Th1 response-directing adjuvant.

58. The method of claim 56 or 57, wherein said adjuvant comprises 3-O-deacyl-4' -monophosphoryl lipid A (MPL), saponin QS-21, a CpG-containing oligonucleotide (CpG ODN), squalene, DL-alpha-tocopherol, and/or imiquimod.

59. A SARS-CoV-2 vaccine obtained or obtainable by the method of any one of claims 36 or 39 to 58.

60. Use of a SARS-CoV-2 vaccine according to any one of claims 1 to 28 or 59 for treating or preventing a SARS-CoV-2infection in a subject.

61. A pharmaceutical composition for use in the prevention or treatment of SARS-CoV-2infection in a subject, wherein the pharmaceutical composition is an inactivated SARS-CoV-2 vaccine as defined in any of claims 1 to 28 or 59, optionally in combination with one or more pharmaceutically acceptable excipients and/or adjuvants.

62. Use of the SARS-CoV-2 vaccine of any one of claims 1 to 28 or 59 as a medicament.

63. The vaccine, method, use or pharmaceutical composition of any preceding claim, wherein the subject is (i) an elderly subject, preferably a subject over 65 years old, over 70 years old or over 80 years old; (ii) an immunocompromised subject; or (iii) a pregnant subject.

64. The vaccine, method, use or pharmaceutical composition according to any preceding claim, for preventing or treating a SARS-CoV-2infection without inducing (i) Antibody Dependent Enhancement (ADE) of SARS-CoV-2 related disease (COVID-19); and/or (ii) immunopathology of the subject.

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