CN115737893A - Surgical suture with antibacterial, anti-inflammatory and barb structure and preparation method thereof - Google Patents
Surgical suture with antibacterial, anti-inflammatory and barb structure and preparation method thereof Download PDFInfo
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- CN115737893A CN115737893A CN202211435053.7A CN202211435053A CN115737893A CN 115737893 A CN115737893 A CN 115737893A CN 202211435053 A CN202211435053 A CN 202211435053A CN 115737893 A CN115737893 A CN 115737893A
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- suture
- barb structure
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- inflammatory
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 33
- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title abstract description 24
- 239000000835 fiber Substances 0.000 claims abstract description 33
- 238000000034 method Methods 0.000 claims abstract description 14
- 229920000642 polymer Polymers 0.000 claims abstract description 14
- 229920001661 Chitosan Polymers 0.000 claims abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 13
- 229920001610 polycaprolactone Polymers 0.000 claims abstract description 11
- 239000004632 polycaprolactone Substances 0.000 claims abstract description 11
- 102000008186 Collagen Human genes 0.000 claims abstract description 10
- 108010035532 Collagen Proteins 0.000 claims abstract description 10
- 229920001436 collagen Polymers 0.000 claims abstract description 10
- 229920001577 copolymer Polymers 0.000 claims abstract description 9
- 230000008569 process Effects 0.000 claims abstract description 8
- 229940124599 anti-inflammatory drug Drugs 0.000 claims abstract description 7
- 229940124350 antibacterial drug Drugs 0.000 claims abstract description 7
- 229940079593 drug Drugs 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 claims description 22
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 15
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 12
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 12
- 239000004626 polylactic acid Substances 0.000 claims description 12
- 238000009987 spinning Methods 0.000 claims description 11
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 10
- 108010022355 Fibroins Proteins 0.000 claims description 7
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 7
- 238000013329 compounding Methods 0.000 claims description 7
- 239000002105 nanoparticle Substances 0.000 claims description 7
- 229960003500 triclosan Drugs 0.000 claims description 7
- 239000004148 curcumin Substances 0.000 claims description 6
- 229940109262 curcumin Drugs 0.000 claims description 6
- 235000012754 curcumin Nutrition 0.000 claims description 6
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 6
- 229960003957 dexamethasone Drugs 0.000 claims description 6
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims description 6
- 238000002074 melt spinning Methods 0.000 claims description 6
- 229920005615 natural polymer Polymers 0.000 claims description 6
- 229920001059 synthetic polymer Polymers 0.000 claims description 6
- 238000001746 injection moulding Methods 0.000 claims description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- 229920000954 Polyglycolide Polymers 0.000 claims description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 3
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims description 3
- 229960005091 chloramphenicol Drugs 0.000 claims description 3
- 229910052802 copper Inorganic materials 0.000 claims description 3
- 239000010949 copper Substances 0.000 claims description 3
- 239000000155 melt Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000000465 moulding Methods 0.000 claims description 3
- 239000004633 polyglycolic acid Substances 0.000 claims description 3
- 229910052709 silver Inorganic materials 0.000 claims description 3
- 239000004332 silver Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 5
- 208000027418 Wounds and injury Diseases 0.000 abstract description 5
- 230000009286 beneficial effect Effects 0.000 abstract description 4
- 230000008439 repair process Effects 0.000 abstract description 3
- 230000002045 lasting effect Effects 0.000 abstract description 2
- 239000002131 composite material Substances 0.000 description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- XBBVURRQGJPTHH-UHFFFAOYSA-N 2-hydroxyacetic acid;2-hydroxypropanoic acid Chemical compound OCC(O)=O.CC(O)C(O)=O XBBVURRQGJPTHH-UHFFFAOYSA-N 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 2
- BERDEBHAJNAUOM-UHFFFAOYSA-N copper(I) oxide Inorganic materials [Cu]O[Cu] BERDEBHAJNAUOM-UHFFFAOYSA-N 0.000 description 2
- KRFJLUBVMFXRPN-UHFFFAOYSA-N cuprous oxide Chemical compound [O-2].[Cu+].[Cu+] KRFJLUBVMFXRPN-UHFFFAOYSA-N 0.000 description 2
- 229940112669 cuprous oxide Drugs 0.000 description 2
- 238000005034 decoration Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 238000009998 heat setting Methods 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 238000004804 winding Methods 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000002166 wet spinning Methods 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention provides an operation suture with an antibacterial, anti-inflammatory and barb structure and a preparation method thereof, belonging to the technical field of medical machinery. The surgical suture is mainly prepared from an outer layer of a barb structure and an inner layer of force-bearing fibers; the outer layer of the barb structure mainly comprises a polymer carrier and a functional drug; the polymer carrier comprises at least one of polycaprolactone, polylactic acid-glycolic acid copolymer, collagen or chitosan; the functional drugs include antibacterial and/or anti-inflammatory drugs. The suture effectively combines the barb structure and the antibacterial and anti-inflammatory functional components through a simple two-layer structure, has controllable structure and lasting function, and is beneficial to accurate repair of wounds; meanwhile, the preparation method has simple process and strong designability, and is convenient for continuous preparation and precise performance regulation.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to an operation suture with an antibacterial, anti-inflammatory and barb structure and a preparation method thereof.
Background
Sutures are common medical devices used for suturing tissue wounds in surgical operations, and with the development of material science and processing technology, the materials tend to be absorbable so as to avoid the pain of patients caused by postoperative suture removal. However, the suture is often fixed by knotting in the surgical process, and for absorbable sutures, the formed knotted structure is not favorable for precise tissue repair, and scars and other defects can be formed.
Therefore, in recent years, sutures having a barb structure on the surface thereof have been produced, and tissues near a wound are fixed by the barbs, so that the repair accuracy of damaged tissues is improved without knotting. However, the processing of the barb structure is complex, and it is not easy to introduce (antibacterial, anti-inflammatory, etc.) functional components in the processing process, so that the barb suture with functions in the prior art has fewer types, and has a multi-layer complex structure, which is not beneficial to continuous preparation.
Disclosure of Invention
In view of this, the present invention aims to provide an operation suture with antibacterial, anti-inflammatory and barb structure and a preparation method thereof. The suture effectively combines the barb structure and the antibacterial and anti-inflammatory functional components through a simple two-layer structure, has controllable structure and lasting function, and is beneficial to accurate repair of wounds; meanwhile, the preparation method has simple process and strong designability, and is convenient for continuous preparation and precise performance regulation.
In order to achieve the above purpose, the invention provides the following technical scheme:
the invention provides an operation suture with an antibacterial, anti-inflammatory and barb structure, which is mainly prepared from an outer layer of the barb structure and an inner layer of force-bearing fibers; the outer layer of the barb structure mainly comprises a polymer carrier and a functional medicament; the polymer carrier comprises at least one of polycaprolactone, polylactic acid-glycolic acid copolymer, collagen or chitosan; the functional drugs include antibacterial and/or anti-inflammatory drugs.
Preferably, the main component of the force bearing fiber comprises synthetic polymer and/or natural polymer; the synthetic polymer comprises polylactic acid and/or polyglycolic acid; the natural polymer comprises one or more of fibroin, collagen or chitosan.
Preferably, the main component of the force-bearing fiber also comprises antibacterial functional nanoparticles loaded with silver, copper and zinc elements.
Preferably, the force bearing fiber is monofilament or multifilament.
Preferably, the antibacterial and/or anti-inflammatory drug comprises one or more of synthetic micromolecules such as chloramphenicol, triclosan and dexamethasone or natural extracts such as curcumin.
Preferably, the barb structure is angled from 30 to 60 ° to the axial direction of the suture.
The invention also provides a preparation method of the surgical suture, which comprises the following steps:
(1) Hybridizing the main components of the bearing fiber with the functional nano particles, and carrying out melt spinning or solution spinning to prepare monofilament or multifilament as the bearing fiber;
(2) And (3) blending the polymer carrier with the functional medicine in the form of melt or solution, and compounding the polymer carrier serving as an outer layer with the force-bearing fiber in the step (1) by means of a barb structure die to form the barb structure suture.
Preferably, the melt in step (2) comprises a polycaprolactone melt.
Preferably, the solution in step (2) comprises an acetone solution of polylactic acid-glycolic acid copolymer, and an acetic acid solution of collagen or chitosan.
Preferably, the compounding process in step (2) includes hot press molding or injection molding.
Compared with the prior art, the invention has the beneficial effects that:
the surgical suture provided by the invention overcomes the problem that the combination of a suture surface barb structure and antibacterial and anti-inflammatory components is difficult, and the two components are combined integrally through a simple structure of two layers; the suture structure of the two components is controllable, the functions are durable, the interference of suture knotting, bacterial infection and inflammation on skin tissue repair is effectively inhibited, and the scarless healing of wounds is promoted. The preparation method comprises the spinning preparation of the bearing fiber, the composite preparation of the outer layer and the processing of the barb structure; the method has the advantages of simple process, high continuous feasibility, strong designability of fiber spinning and structure processing technologies, and capability of accurately regulating and controlling components and structures according to subsequent clinical requirements. .
Detailed Description
The invention provides an operation suture with antibacterial, anti-inflammatory and barb structure, which is mainly prepared from an outer layer of the barb structure and an inner layer of bearing fiber; the outer layer of the barb structure mainly comprises a polymer carrier and a functional medicament; the polymer carrier comprises at least one of polycaprolactone, polylactic acid-glycolic acid copolymer, collagen or chitosan; the functional drugs include antibacterial and/or anti-inflammatory drugs.
In the present invention, the messenger fiber is preferably a monofilament or a multifilament. Wherein, the main component of the force bearing fiber preferably comprises synthetic polymer and/or natural polymer; the synthetic polymer preferably comprises polylactic acid and/or polyglycolic acid; the natural polymer preferably comprises one or more of fibroin, collagen or chitosan. The source of the raw materials is not particularly limited in the present invention, and the raw materials can be obtained by using a commercially available product or a method conventionally used in the art.
In the invention, the main component of the force bearing fiber preferably also comprises antibacterial functional nanoparticles loaded with silver, copper and zinc elements. Specifically, the antibacterial functional nano particles are loaded according to the requirements of the bearing fiber.
In the present invention, the antibacterial and/or anti-inflammatory drug preferably comprises one or more of chloramphenicol, triclosan, curcumin or dexamethasone. The source of the medicament is not particularly limited, and the medicament can be prepared from conventional commercial products.
In the present invention, the barb structure is preferably at an angle of 30-60 °, more preferably 45 °, to the axial direction of the suture.
The invention also provides a preparation method of the surgical suture, which comprises the following steps:
(1) Hybridizing the main components of the bearing fiber with the functional nano particles, and carrying out melt spinning or solution spinning to prepare single filaments or multifilament serving as the bearing fiber;
(2) And (3) blending the polymer carrier with the functional medicine in the form of melt or solution, and compounding the polymer carrier serving as an outer layer with the force-bearing fiber in the step (1) by means of a barb structure die to form the barb structure suture.
In the present invention, the melt in the step (2) preferably comprises a polycaprolactone melt; the solution preferably comprises an acetone solution of polylactic acid-glycolic acid copolymer, an acetic acid solution of collagen or chitosan.
In the present invention, the compounding process in the step (2) preferably includes hot press molding or injection molding.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
A surgical suture, in particular to an absorbable antibacterial suture with a barb structure, which comprises a barb structure on the outer layer and force bearing fibers on the inner layer; the components of the outer layer of the barb structure are polycaprolactone and triclosan, the components of the inner layer of the barb structure are polylactic acid multifilament, and the angle formed by the barb structure and the axial direction of the suture is 60 degrees.
The preparation method comprises the following steps:
(1) Spinning preparation of bearing fiber
The polylactic acid slices are dried in vacuum for 12h at 100 ℃ by a vacuum drum oven. The dried polylactic acid chips were subsequently melt spun into fibers in multifilament form by means of a melt spinning apparatus, the spinning process being as follows:
screw extrusion temperature: 220 deg.C
The temperature of the box body is as follows: 230 ℃ C
Winding speed: 2500m/min
Drafting temperature: 60 deg.C
Draft multiple: 2.5 times of
Heat-setting temperature: 100 deg.C
(2) Composite preparation of barbed antibacterial suture
Dissolving polycaprolactone in dichloromethane to prepare a solution of 100mg/mL, adding triclosan according to the concentration of 0.1mg/mL, stirring uniformly, and removing the dichloromethane in a vacuum environment at normal temperature to obtain the blend of the polycaprolactone and the triclosan.
And (2) adopting an injection mold with a 60-degree barb structure, putting the polylactic acid monofilament prepared in the step (1) in the middle of the mold, performing injection molding by taking a blend of polycaprolactone and triclosan as a raw material, wherein the injection molding temperature is 100 ℃, and demolding after cooling to obtain the composite suture. The included angle between the barb structure of the prepared suture and the axial direction of the suture is about 60 degrees, the antibacterial rate to escherichia coli and staphylococcus aureus reaches 99 percent, and no obvious toxicity is generated when the suture is co-cultured with epidermal fibroblasts.
Example 2
A surgical suture, in particular to an absorbable antibacterial and anti-inflammatory suture with a barb structure, which comprises a barb structure on the outer layer and force-bearing fibers on the inner layer; the components of the outer layer of the barb structure are poly (lactic acid-glycolic acid) copolymer and dexamethasone (anti-inflammatory function), the components of the inner layer are polylactic acid monofilament loaded with nano cuprous oxide (antibacterial function), and the angle formed by the barb structure and the axial direction of the suture is 30 degrees.
The preparation method comprises the following steps:
(1) Spinning preparation of bearing fiber
The polylactic acid slices are dried in vacuum for 12h at 100 ℃ by a vacuum drum oven. And hybridizing and granulating the polylactic acid slices and the nano cuprous oxide according to the mass ratio of 9.
Then compounding the polylactic acid slices and the hybrid master batches according to the mass ratio of 9, carrying out vacuum drying for 12h at 100 ℃, and carrying out melt spinning processing to obtain the fiber in the form of monofilaments by using melt spinning equipment, wherein the spinning process comprises the following steps:
screw extrusion temperature: 205 deg.C
The temperature of the box body is as follows: 220 deg.C
Winding speed: 1200m/min
Drafting temperature: 70 deg.C
Draft multiple: 4 times of
Heat setting temperature: 110 deg.C
(2) Composite preparation of barbed antibacterial suture
Firstly, poly (lactic acid-glycolic acid) copolymer is dissolved in acetone to prepare 100mg/mL solution, and then dexamethasone is added according to the concentration of 0.1mg/mL to be stirred until the solution is uniform.
And (2) adopting an injection mold with a 30-degree barb structure, putting the polylactic acid monofilament prepared in the step (1) in the middle of the mold, pouring a mixed solution of poly (lactic acid-glycolic acid) copolymer and dexamethasone into the mold, and removing acetone in a normal-temperature vacuum environment to obtain the composite suture. The included angle between the barb structure of the prepared suture and the axial direction of the suture is about 30 degrees, the antibacterial rate to escherichia coli and staphylococcus aureus reaches 99 percent, and meanwhile, the suture is co-cultured with epidermal fibroblasts without generating obvious toxicity, so that macrophage inflammation is effectively inhibited.
Example 3
A surgical suture, in particular to an absorbable antibacterial and anti-inflammatory suture with a barb structure, which comprises a barb structure on the outer layer and a force bearing fiber on the inner layer; the composition of the outer layer of the barb structure is chitosan (anti-inflammatory function) and curcumin (antibacterial function), the composition of the inner layer is silk fibroin multifilament, and the angle formed by the barb structure and the axial direction of the suture is 45 degrees.
The preparation method comprises the following steps:
(1) Spinning preparation of bearing fiber
Preparing 20wt% silk fibroin aqueous solution as spinning solution, adopting 60 deg.C 35wt% ammonium sulfate aqueous solution as coagulating bath, and wet spinning (spinneret orifice diameter 150 μm, drafting magnification 7 times) to obtain silk fibroin multifilament.
(2) Composite preparation of barbed functional sutures
Firstly, dissolving chitosan in 0.1mol/L acetic acid to prepare a 40mg/mL solution, then adding curcumin according to the concentration of 0.1mg/mL, and stirring until the mixture is uniform.
And (2) adopting an injection mold with a 45-degree barb structure, putting the silk fibroin multifilament prepared in the step (1) in the middle of the mold, pouring a mixed solution of chitosan and curcumin into the mold, and then removing the acetic acid solution at 40 ℃ in a vacuum environment to obtain the composite suture. The included angle between the barb structure of the prepared suture and the axial direction of the suture is about 45 degrees, the antibacterial rate to escherichia coli and staphylococcus aureus reaches 99 percent, and meanwhile, the suture is co-cultured with epidermal fibroblasts without generating obvious toxicity, so that macrophage inflammation is effectively inhibited.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. An operation suture with antibacterial, anti-inflammatory and barb structure is characterized in that the operation suture is mainly prepared by an outer layer of the barb structure and an inner layer of force bearing fiber; the outer layer of the barb structure mainly comprises a polymer carrier and a functional drug; the polymer carrier comprises at least one of polycaprolactone, polylactic acid-glycolic acid copolymer, collagen or chitosan; the functional drugs include antibacterial and/or anti-inflammatory drugs.
2. The surgical suture of claim 1, wherein the main component of the force bearing fiber comprises synthetic polymer and/or natural polymer; the synthetic polymer comprises polylactic acid and/or polyglycolic acid; the natural polymer comprises one or more of fibroin, collagen or chitosan.
3. The surgical suture of claim 2, wherein the force bearing fiber mainly comprises antibacterial functional nanoparticles loaded with silver, copper and zinc elements.
4. The surgical suture of claim 1 or 2, wherein the messenger fiber is a monofilament or multifilament.
5. The surgical suture of claim 1, wherein the antibacterial and/or anti-inflammatory drug comprises one or more of a synthetic small molecule such as chloramphenicol, triclosan, dexamethasone, or a natural extract such as curcumin.
6. A surgical suture according to claim 1, wherein the barb structure is angled from 30 to 60 ° to the axial direction of the suture.
7. The method for preparing a surgical suture according to any one of claims 1 to 6, comprising the steps of:
(1) Hybridizing the main components of the bearing fiber with the functional nano particles, and carrying out melt spinning or solution spinning to prepare single filaments or multifilament serving as the bearing fiber;
(2) And (3) blending the polymer carrier with the functional medicine in the form of melt or solution, and compounding the polymer carrier serving as an outer layer with the force-bearing fiber in the step (1) by means of a barb structure die to form the barb structure suture.
8. The method of claim 7, wherein the melt in step (2) comprises a polycaprolactone melt.
9. The method of claim 7, wherein the solution in step (2) comprises an acetone solution of poly (lactic-co-glycolic acid), an acetic acid solution of collagen or chitosan.
10. The method for preparing surgical suture according to claim 7, wherein the compounding process in step (2) comprises hot press molding or injection molding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211435053.7A CN115737893A (en) | 2022-11-16 | 2022-11-16 | Surgical suture with antibacterial, anti-inflammatory and barb structure and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211435053.7A CN115737893A (en) | 2022-11-16 | 2022-11-16 | Surgical suture with antibacterial, anti-inflammatory and barb structure and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN115737893A true CN115737893A (en) | 2023-03-07 |
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| CN202211435053.7A Pending CN115737893A (en) | 2022-11-16 | 2022-11-16 | Surgical suture with antibacterial, anti-inflammatory and barb structure and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075544A (en) * | 2016-01-26 | 2016-11-09 | 西北工业大学 | A kind of core shell composite construction medicine carrying stitching thread and preparation method thereof |
| CN108853562A (en) * | 2018-09-13 | 2018-11-23 | 王传强 | A kind of absorbable pre-knotted operation suture thread of thoracic surgery sustained antiinfective |
| WO2020015046A1 (en) * | 2018-07-20 | 2020-01-23 | 南通纺织丝绸产业技术研究院 | Surgical suture with natural antibacterial drug sustained release function and preparation method therefor |
| CN112516372A (en) * | 2020-11-12 | 2021-03-19 | 盐城工学院 | Composite drug-loaded fiber for absorbable surgical suture |
| CN113197705A (en) * | 2021-04-02 | 2021-08-03 | 苏州大学 | Barbed silk suture line and preparation method thereof |
-
2022
- 2022-11-16 CN CN202211435053.7A patent/CN115737893A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075544A (en) * | 2016-01-26 | 2016-11-09 | 西北工业大学 | A kind of core shell composite construction medicine carrying stitching thread and preparation method thereof |
| WO2020015046A1 (en) * | 2018-07-20 | 2020-01-23 | 南通纺织丝绸产业技术研究院 | Surgical suture with natural antibacterial drug sustained release function and preparation method therefor |
| CN108853562A (en) * | 2018-09-13 | 2018-11-23 | 王传强 | A kind of absorbable pre-knotted operation suture thread of thoracic surgery sustained antiinfective |
| CN112516372A (en) * | 2020-11-12 | 2021-03-19 | 盐城工学院 | Composite drug-loaded fiber for absorbable surgical suture |
| CN113197705A (en) * | 2021-04-02 | 2021-08-03 | 苏州大学 | Barbed silk suture line and preparation method thereof |
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