CN115715663A

CN115715663A - Accurate screening system for cervical cancer

Info

Publication number: CN115715663A
Application number: CN202211278364.7A
Authority: CN
Inventors: 黄健
Original assignee: Shanghai Fly Medical Devices Co ltd
Current assignee: Shanghai Fly Medical Devices Co ltd
Priority date: 2019-10-22
Filing date: 2019-10-22
Publication date: 2023-02-28
Also published as: CN110664365A

Abstract

The invention discloses an accurate cervical cancer screening system which comprises a digital electronic colposcope, an expander, an intelligent terminal and a cervical disease management platform, wherein the digital electronic colposcope can be fixedly arranged at the rear end of the expander and is used for observing a cervix, and transmitting an observed cervix image to the intelligent terminal through a network; the intelligent terminal is provided with a colposcope examination APP for receiving and displaying cervical images observed by a digital electronic colposcope and guiding accurate sampling of the cervix under a visual condition, and the cervical images are further uploaded to a cervical disease management platform; the cervical disease management platform comprises a cervical disease cloud database for medical experts to remotely share screened cervical images. The cervical cancer accurate screening system provided by the invention has the advantages that the accuracy of cervical cancer accurate screening is obviously improved, and meanwhile, the comprehensive management of screening, diagnosis and follow-up visit of female cervical diseases is realized.

Description

Accurate screening system for cervical cancer

The application is a divisional application of a Chinese patent application with the application date of 2019, 10 and 22 months, the application number of 201911003032.6 and the invention name of a cervical cancer accurate screening system.

Technical Field

The invention relates to a medical system based on internet and cloud data, in particular to an accurate cervical cancer screening system.

Background

Cervical Cancer is the most common malignancy in women, with approximately 50 million cases of cervical Cancer occurring each year worldwide, with approximately 20 million people dying from cervical Cancer [ CA Cancer J clin.2005, 55. Of these, 80% occur in relatively poor countries, the main reason for this being the lack of effective screening means and treatment protocols [ Obstet Gyneclo Clin North Am,2007, 34. The national Cancer center published data in 2019, which shows that about 10 million new cases and about 3.05 million deaths of cervical Cancer in 2015 exist [ CA Cancer J clin.2016, 66. China tumor journal, 2019, 41. According to literature, the cervical cancer of China can be up to 15 ten thousand people at the end of 2018 years. Cervical cancer incidence did not enter the top 10 in developed countries, ranked 2 nd in developed countries, mortality ranked 9 th in developed countries, and 3 rd in developed countries.

In order to reduce the incidence rate of cervical cancer, the government of China tries to screen cervical cancer of women in rural areas from 2009, and proposes 2011-2020 development outline of Chinese women in 2010, and requires that the popularization rate of screening cervical cancer of China in 2020 reaches more than 80%. However, after 10 years, the expected inflection point of a large decrease in the incidence of cervical cancer does not appear, but tends to increase continuously, and particularly the trend toward the young is remarkable [ journal of Chinese tumor, 2019, 41 (1): 19-28]. Through years of research and research on screening sites of cervical cancer in many places in China, the following pain points exist in a cervical cancer screening system in China:

1. the sampling is not accurate enough

In the cervical cancer screening process, no matter HPV typing, cytology technology or other technologies (such as gene detection and the like) are used for cervical cancer screening, cervical exfoliated cell samples need to be obtained. However, in the real work, factors such as the responsibility of operators, the technical level, the structure and quality of the material-taking apparatus, the position of pathological changes and the like can cause inaccurate sampling, thereby causing false negative of the inspection result and delaying the diagnosis and treatment time of diseases [ cervical cancer spodiophora aquatica 2018 view.

2. Process invalidation management

At present, the work of providing free cervical cancer screening for 1000 ten thousand women of suitable ages in China each year is to assign all levels of health management departments in a task decomposition mode and then to be implemented by primary women and children health care hospitals. The implementation process is an assault type sports battle, centralized screening is carried out in a short time, the labor intensity is high, and the screening quality is difficult to ensure. The screening result is judged only by counting reported numbers. Screening work in various places is not systematic, an electronic traceable chronic disease follow-up system and platform are not formed, and abnormal people cannot be really tracked and managed. Particularly, people with abnormal virology or cytology results but poor medical compliance lose control, still have high risk of cancer, and if the management is not in place, the early screening loses significance.

3. Screening techniques are not integrated

At present, HPV and/or TCT technology is commonly used in cervical cancer screening in China. Research shows that any single technology has defects in identifying cervical cancer. For example, the TCT detection technology is relatively simple and convenient to operate, has low cost, but has low sensitivity, a certain missed diagnosis rate, and even possible misdiagnosis, and the primary hospital lacks experienced cytopathologists, and has low screening efficiency for large-scale population. The purpose of quickly and accurately screening large-scale people cannot be achieved. In addition, because the level of detection personnel and the advanced degree of detection equipment of each bearing unit are greatly different, the unified standard is difficult to be strictly followed, the difference of the detection service level is large, and even missed diagnosis and misdiagnosis occur. Therefore, there is a need in the field of cytological assays for artificial intelligence devices and techniques that can be applied on a large scale to reduce the effect of assay personnel level irregularities on the results.

In addition, a number of epidemiological and biological studies have demonstrated that HPV infection is a prerequisite for cervical cancer or pre-cervical lesions. Therefore, HPV-DNA detection becomes an auxiliary cervical cancer screening technology. With the progress of high-risk HPV detection technology, the diagnostic value of HPV typing has been widely accepted by clinicians. However, it is not necessary for patients with HPV infection to develop cervical lesions, since most female infections with HPV have a transient character and can be cleared by the immune system of the female within 1-2 years. Only those long-term, persistent high-risk types of HPV infection are likely to lead to the development of cervical cancer. Thus, patients who are simply HPV positive require long-term follow-up and continuous testing.

VIA/VILI (acetic acid-iodine test) visual inspection was the primary screening method for cervical cancer screening in the 90's of the 20 th century. The method is characterized in that a chemical solution is used for staining the cervix after being smeared on the cervix, and the cervix is directly observed by naked eyes for staining reaction of the cervix epithelium without amplification by incandescent light illumination so as to judge whether the cervix has pathological changes. There are two visual methods: (1) VIA (visual infection with acetic acid), the result was visually observed after staining the cervix with a 5% acetic acid solution; (2) VILI (visual infection with Lugol's iodine), the result was visually observed after staining the cervix with 5% compound iodine solution. In a strict sense, the VIA/VILI technique also falls within the category of cytological assays. The principle of VIA is that nuclear protein and keratin are coagulated and precipitated to prevent light from transmitting through the epithelial layer, so that the blood vessels under the epithelium are unclear and are not easy to see, and the epithelium is white. The principle of VILI is that normal squamous epithelial cells contain glycogen, glycogen has affinity with iodine, the epithelium is dyed into tan or black after being coated with iodine solution, abnormal areas (CIN or inflammation and the like) of the squamous epithelium have low glycogen content or do not contain glycogen, so the squamous epithelium is not dyed or partially dyed, and the squamous epithelium looks yellow or mustard. The VIA/VILI with visual observation has the advantages of low cost and capability of realizing 'screening and diagnosis'. However, the above other methods cannot achieve the purpose of screening and diagnosing immediately, and a period of time is required to wait for the result to be obtained after sampling. VIA/VILI by visual observation has the disadvantages that physical strength is consumed by visual observation, and the influence of external environment is large; the VIA cannot automatically time when observing; the results cannot be stored, and once the optimal observation period is missed, the experimental process cannot be reproduced in time, so that detection failure is caused. Therefore, the sensitivity and specificity are low, the neck tube lesion is not easy to be found, and the quality control is difficult.

4. The control system does not form a long-acting mechanism

In the 2009 notification of carrying out cervical cancer screening of rural women in China, a 'two-cancer' examination service mode and an optimization scheme for exploring women suitable for basic level are written in a project target every year, and a 'two-cancer' long-acting mechanism is gradually established. Over the past 10 years, the long-acting mechanism of such cervical cancer prevention systems has not been established. The cervical cancer prevention and treatment system in China lacks an industrial standard and a systematized technical platform. After years of practice, people can deeply realize that the cervical cancer problem cannot be solved at all by the current discontinuous and movable screening mode which covers a few people and adopts a single technology. The fundamental problem of cervical cancer prevention and treatment can only be solved by adopting a full-coverage, continuous, long-acting and multi-technology-integrated standardized and systematic screening mode.

Cervical cancer is a disease that can be prevented and cured. The rapid development of accurate cervical cancer screening technology and system is the key to early detection of cervical cancer.

China is the biggest developing country in the world and is also a high-incidence country of cervical cancer, and the number of new-onset cervical cancer cases accounts for about 28 percent of the total incidence number in the world each year. This is associated with the lack of a systematically effective cervical cancer screening system and disease treatment technologies in developing countries. The screening of cervical cancer plays an important role in reducing the incidence and death rate of cervical cancer as a secondary prevention measure of cervical cancer. The cervical cancer screening mode in western countries has high cost and slow speed, and is not completely suitable for the national conditions of China. Therefore, the method has very important practical significance for exploring a novel advanced, accurate, rapid and low-cost accurate cervical cancer screening new mode suitable for the national conditions of China and a technical system convenient for standardized operation of a front-line doctor.

Disclosure of Invention

The invention aims to solve the technical problems of inaccurate sampling and the like in the existing cervical cancer accurate screening work, and provides the cervical cancer accurate screening system.

In order to solve the technical problems, the invention adopts the following technical scheme:

an accurate cervical cancer screening system comprises a digital electronic colposcope, a dilator, an intelligent terminal and a cervical disease management platform,

the digital electronic colposcope can be fixedly arranged at the rear end of the dilator and is used for observing the cervix uteri and transmitting an observed cervix uteri image to the intelligent terminal through a network;

the intelligent terminal is provided with a colposcope examination APP for receiving and displaying cervical images observed by a digital electronic colposcope and guiding accurate sampling of the cervix under a visual condition, and the cervical images are further uploaded to a cervical disease management platform;

the cervical disease management platform comprises a cervical disease cloud database for medical experts to remotely share screened cervical images.

The digital electronic colposcope is a portable miniature digital electronic colposcope, can automatically take or record pictures of observed cervix uteri at regular time, and can automatically store cervix uteri images.

The digital electronic colposcope video can record the whole cervical sampling process, really realize visual accurate sampling and effectively solve the problem of lack of quality control standards in cervical cancer screening work.

Accurate sample adopts disposable flocking sample brush and electronic sampler, disposable flocking sample brush sets up in the rotatory cover of electronic sampler head.

The samples obtained by accurate sampling are used for HPV and TCT detection.

One of the most important features of the present invention is the accurate acquisition of cervical samples.

The accurate acquisition of the cell sample at the cervical lesion is the premise of ensuring the accuracy of the result, and if the accurate cervical cell sampling is not available, the level of the follow-up slide production and pathology reading doctors is higher, the molecular detection technology is advanced, and the accurate result cannot be obtained. The cervical cancer accurate screening system provided by the invention can ensure sampling accuracy from three aspects. (1) By utilizing the portable digital electronic colposcope system, an operator can be ensured to accurately identify the position of the cervical orifice under the visual condition, the accuracy of a sampling position is ensured, and pictures are stored for later inspection. (2) The plastic brush easy to miss detection is changed into the flocking brush made of high polymer materials, so that the single sampling amount is increased, and the phenomenon of blood contact is reduced. (3) The problem of individual difference of doctor's sample is solved ingeniously through automatic sampling equipment, has thoroughly solved the industry pain point of sampling irregularity in the gynaecology field.

The invention can accurately obtain the sample amount required by HPV and TCT detection by one person brushing one tube without sampling for multiple times, and can avoid the embarrassment that abnormal cells cannot be collected when secondary sampling is carried out on tiny focuses. Compared with the traditional manual sampling, the invention has the advantages that the number of sampled cells is obviously increased, the requirements of cytology and HPV typing are met, and the blood contact phenomenon is obviously reduced. When different doctors take samples, the same time and the same force can be achieved, and a powerful technical basis is laid for the standardization of sample collection.

Another important feature of the present invention is the integration of multiple detection techniques.

At present, a plurality of cervical cancer primary screening technologies exist in China, but the single use of various technologies has defects. Such as: although the HPV typing result is well related to HSIL (suspected cervical invasive carcinoma), the positive rate (10-15%) of HPV in the human population is significantly higher than the detection result (3-5%) of TCT. The simple TCT technology has low sensitivity and poor specificity, and is easy to cause large-scale omission. Besides the lesion of the cervical orifice, the lesion of the lip of the cervix can be found by a VIA/VILI (acetic acid-iodine test) visual observation method, but the lesion of the cervical orifice is not easy to find. Colposcopy techniques need to be combined with other techniques to effectively perform its function. However, the large-scale colposcope which is used in clinical routine at present is not suitable for the high-intensity work of large-scale cervical cancer screening in rural areas due to the characteristics of high price, large volume, difficulty in moving and the like. The portable digital electronic colposcope system not only can be matched with VIA/VILI to improve the positive diagnosis rate, but also can ensure that doctors can realize accurate sampling under visualization, thereby ensuring the accuracy of subsequent detection results. Furthermore, all data can be archived for traceability.

The cervical cancer accurate screening system can integrate the advantages of various technologies such as visual sampling, VIA/VILI, HPV, TCT and the like, greatly improve the negative prediction value and positive detection rate of cervical cancer screening, furthest detect high-risk groups and lay a foundation for subsequent confirmation. According to the cervical cancer screening process published by the government of China, a new round of screening is introduced after 3 years, so that the screening cost can be greatly and scientifically saved, and the scientific judgment cannot be realized by any single technology.

A third feature of the present invention is to effectively manage the screening process.

In the past, the cervical cancer screening work of task completion generally has the pain points of difficult propaganda and mobilization, poor compliance of abnormal result referral, high follow-up diagnosis and treatment failure rate and the like. The portable digital electronic colposcope system disclosed by the invention well solves the problems by utilizing the thinking of the Internet of things. Carrying out visual accurate sampling by using a portable digital electronic colposcope, wherein the sample is used for HPV, TCT and other gene detection; the VIA/VILI result under the portable digital electronic colposcope is used for judging the abnormality of the cervical orifice and the cervical lip, and the purpose of screening and diagnosing is realized. Meanwhile, VIA/VILI images under the portable digital electronic colposcope and results of HPV, TCT and the like are uploaded to a cervical disease management platform, so that subsequent examination, follow-up visit and data statistics are facilitated; the expert team utilizes the cervical disease management platform to synthesize various technical parameters for remote diagnosis of cervical diseases, and accurately guides first-line screening work and management of screening crowd.

The accurate cervical cancer screening system and the screening integration scheme thereof not only can find low-level/high-level pathological changes, suspicious cervical cancer and the like, but also can find other various gynecological diseases closely related to tumorigenesis and development, including subclinical virus infection, erosion, cervical inflammation, polyp, trichomonas infection, nashin's cyst, endometriosis, uterine prolapse and the like. The results provide accurate basis for guiding the screened women to carry out subsequent accurate diagnosis and treatment. Scientific studies have confirmed that gynecological inflammation has a clear correlation with the occurrence and development of gynecological malignant tumors. Therefore, the early treatment of the gynecological diseases has very important significance for preventing and treating the cervical cancer. The standardized and systematized integrated screening scheme of the invention can lay a solid foundation for transformation and upgrading of the cervical cancer screening industry in China.

The intelligent terminal comprises a flat panel display such as a tablet personal computer and a smart phone and is used for displaying the cervical image of the examinee observed by the digital electronic colposcope in real time through a wireless network, uploading the cervical image to the cervical disease management platform, or instructing the printer to print the cervical image observed by the digital electronic colposcope according to the requirement.

Colposcopy APP includes image acquisition module, user interaction module, this image acquisition module, user interaction module with cervical disease management platform passes through network connection. The colposcopy APP comprises a plurality of login or registration ports, including a common user port and a doctor user port.

The common user port is provided with an electronic registration system, and the electronic registration system comprises a two-dimensional code special for scanning and screening and self-inputting personal information or an identity card.

The accuracy of the field input data is an important basis for ensuring the smooth development of screening work, process management and result statistics. Therefore, in a preferred embodiment of the invention, the tablet computer providing the android system performs the personal information input work. The accurate cervical cancer screening system provided by the invention realizes paperless operation, and women needing screening can autonomously input personal information by scanning the special screening two-dimensional code so as to improve the efficiency of on-site screening; meanwhile, the personal information can be input by scanning the identity card on site, and the personal information can be input by face recognition or swiping a social security card, so that the accuracy and consistency of screening personnel are ensured. The method can accurately input the personal information, and eliminates the error phenomenon frequently occurring when the paper file is manually input the personal information.

The colposcopy APP which enters the common user port has multiple functions, including a medical record uploading function, a medical record inquiring function, a health education function, an expert consultation function, a referral reminding function, a re-diagnosis reminding function and a result reminding function; colposcopy APP that doctor user port got into is equipped with the multinomial function, uploads function, doctor's diagnostic function, referral function, teaching live function including image acquisition function, bar code or two-dimensional code recognition function, image or testing result.

Compared with the prior art, the invention has the following beneficial effects:

(1) The system can improve the sampling accuracy of cervical duct cells and cervical exfoliated cells in cervical cancer screening. The digital electronic colposcope is small in size, portable and portable, is easy to operate by basic medical staff, records the whole acetic acid-iodine test process through an automatic photographing technology, and records the image information of a cervical sampling process, so that accurate sampling is realized, and the diagnosis accuracy is ensured; the portable digital electronic colposcope is used for accurately acquiring the exfoliated cervical cells and completing image acquisition, so that the defects of poor sensitivity and specificity of a screening result caused by non-accurate sampling and technical limitations are greatly reduced. The stored dynamic cervical pictures are convenient for subsequent medical experts to perform remote diagnosis, comparison and timely business guidance, so that the efficiency of cervical cancer screening work is improved, the gynecological diagnosis and treatment level of primary doctors is improved, and the accuracy, the intellectualization and the networking of cervical cancer screening are realized.

(2) Establishing a screening and sampling quality control standard: the visual sampling function is realized by the system, and the system requires that an operator must sample the cervical lesion, otherwise, the operator is regarded as invalid operation and needs to sample again. The system provided by the invention can be used for visually and accurately sampling, and the problem that the cervical cancer screening work lacks quality control standards is skillfully solved.

(3) The system can provide services such as result query, medical guidance, health information, doctor-patient communication, graded diagnosis and treatment, chronic disease follow-up and the like.

(4) The system can be used for acquiring high-quality samples and follow-up data related to the occurrence and development of cervical cancer, and providing theoretical basis and technical support for early warning of cervical cancer.

(5) The screening integration platform system (visual accurate sampling + VIA/VILI + HPV + TCT) of the system has the greatest advantage of greatly improving the negative prediction value and the positive detection rate of cervical cancer screening. All negative people screened by the integration scheme need to be brought into a new round of screening again after 3 years according to a cervical cancer screening process published by the government of China, so that the screening cost is saved scientifically and greatly, and the scientific judgment cannot be realized by any single technology.

Drawings

FIG. 1 is a schematic view of a cervical cancer accurate screening system of the present invention;

FIG. 2 is a schematic view of a motorized sampler and brush of the present invention;

FIG. 3 is a schematic view of the electronic check-in system of the present invention;

FIG. 4 is a schematic diagram of the present invention illustrating the registration of a subject with a tablet computer;

FIG. 5 is a workflow diagram of a cervical cancer accurate screening system of the present invention;

FIG. 6 is a schematic illustration of an examination flow for a cervical cancer accurate screening system of the present invention;

FIG. 7 is a graph showing the results of accurate cervical cancer screening in example 1 of the present invention.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.

As shown in fig. 1, the cervical cancer accurate screening system of the present invention includes a digital electronic colposcope 1, an expander 2, an intelligent terminal 3 and a cervical disease management platform, wherein the digital electronic colposcope 1 can be fixedly disposed at the rear end of the expander 2 for observing the cervix, and transmitting the observed cervix image to the intelligent terminal 3 through a network; the intelligent terminal 3 is provided with a colposcopy APP for receiving and displaying cervical images observed by the digital electronic colposcope and uploading the cervical images to a cervical disease management platform; the cervical disease management platform comprises a cervical disease cloud database, and is used for medical experts to remotely share screened cervical images and make timely and accurate diagnosis.

The digital electronic colposcope in the system has the function of automatically photographing at regular time, can automatically record and store the change rule of the appearance of the cervix during the acetic acid-iodine test (VIA/VILI), and provides data support for the diagnosis and multidisciplinary consultation of subsequent medical experts. On the premise of ensuring the quality of clinical diagnosis and treatment, the working strength of primary-line operators in the basic level is greatly reduced, the problem that diagnostic experts are not in the primary-line in the basic level is solved, and primary-line cervical screening image information in the basic level can be clearly observed only through the Internet.

The digital electronic colposcope in the system also has a video recording function, and the visual and accurate sampling of the cervical canal cells can be realized through the video recording of the digital electronic colposcope, so that the problem that the cervical cancer screening work lacks quality control standards is effectively solved. The sample obtained by accurate sampling is further used for HPV and TCT detection, so that the cervical cancer screening is more accurate, efficient and comprehensive.

The accurate sampling of the invention adopts a disposable flocking sampling brush and an electric sampler, and the disposable flocking sampling brush is arranged in a rotary sleeve at the head of the electric sampler. In an embodiment of the present invention, as shown in fig. 2, the electronic sampler includes a handle 4, a rotary sleeve 5, a motor, a transmission mechanism, and a power supply device, wherein the handle 4 is a pistol-type housing, the motor, the transmission mechanism, and the power supply device are disposed inside the housing, and the rotary sleeve 5 is disposed at an opening of a head of the housing; the motor is respectively connected with the power supply device and the transmission mechanism, and the rotating sleeve 5 is connected with the transmission mechanism; the transmission mechanism is driven by the motor to rotate, and the transmission mechanism drives the rotary sleeve 5 to rotate.

The power supply device comprises a power supply, a circuit board and a switch 6, wherein the circuit board is respectively connected with the power supply, the switch 6 and the motor. The circuit board is provided with a control circuit for controlling the rotating speed, the rotating direction and the rotating turns of the motor.

The rotating sleeve 4 is internally provided with an inserted fixing structure such as a clamping groove and an operating rod 7 (shown in figure 2) for fixing the sampling brush.

The switch 6 is a key arranged on the back side or the inner side outside the pistol type shell, and when medical staff uses the electric sampler for sampling, the medical staff only needs to press the switch key with thumb or forefinger. The switch 6 includes a power switch for turning on the power of the electric sampler and a sampling operation switch which is a sampling operation key, and the sampling brush performs automatic sampling by pressing the key.

The intelligent terminal in the system comprises a flat panel display such as a tablet personal computer and a smart phone and is used for displaying the cervical image of the examinee observed by the digital electronic colposcope in real time through a wireless network, uploading the cervical image to a cervical disease management platform, or instructing a printer to print the cervical image observed by the digital electronic colposcope according to needs.

Colposcopy APP includes image acquisition module, user interaction module, and this image acquisition module, user interaction module pass through network connection with cervical disease management platform. The colposcopy APP comprises a plurality of login or registration ports, including a common user port and a doctor user port.

The common user port is provided with an electronic registration system, and the electronic registration system comprises the steps of automatically inputting personal information by scanning a special two-dimensional code for screening, or filling related personal information in a colposcopy APP for login and registration, or filling related personal information by using a WeChat gateway public number for login and registration and obtaining a personal two-dimensional code, or inputting personal information by scanning an identity card on a card reader (see figure 3).

The accuracy of the field input data is an important basis for ensuring the smooth development of screening work, process management and result statistics. Therefore, in a preferred embodiment of the present invention, a tablet computer providing the android system performs the work of inputting personal information (see fig. 4). The cervical cancer accurate screening system disclosed by the invention realizes paperless operation, and a woman to be screened can autonomously input personal information by scanning a 'special screening two-dimensional code', so that the field screening efficiency is improved; meanwhile, the personal information can be input by scanning the identity card on site, and the personal information can be input by face recognition or swiping a social security card, so that the accuracy and consistency of screening personnel are ensured.

The doctor user port is entered by a doctor user through a WeChat platform, a diagnostic page, or a colposcopy APP registry login.

As shown in fig. 5 and 6, in one embodiment of the present invention, when the cervical cancer accurate screening system of the present invention is used for screening, firstly, a general user fills in relevant personal information in colposcopy APP to perform login registration, or fills in relevant personal information using a WeChat post public number to perform login registration, and obtains a personal two-dimensional code. Before the screening sample, the doctor opens colposcopy APP software and wireless network of installation in the panel computer, scans patient's personal two-dimensional code, scans the test tube bar code again and binds. When carrying out cervical cancer screening, the examinee lies flat on the inspection bed, the doctor puts into the examinee's woman vagina with the expander, be fixed in the observation window of expander rear end through the buckle with digital electron colposcope again, then open digital electron colposcope, also can open digital electron colposcope in advance before the screening and make it be in the standby state, install colposcope inspection APP software in this panel computer display, the doctor is some to open the image acquisition module in the colposcope inspection APP software, gather the cervical image that digital electron colposcope observed through wireless network. When the acetic acid-iodine (VIA/VILI) detection is carried out on the cervix, the timing automatic photographing function of the digital electronic colposcope can automatically record and store the whole process of the acetic acid-iodine test, meanwhile, the photographed cervix change image is transmitted to the tablet personal computer through a wireless network, the tablet personal computer can receive and display the cervix image change of the detected person observed by the digital electronic colposcope in real time, and a doctor uploads all collected cervix images to the cervix disease management platform.

When sampling cervical canal cells of a cervix, the visual and accurate sampling of the cervical canal cells can be realized by the video recording function of the digital electronic colposcope. When taking a sample, the doctor inserts the action bars of disposable sample brush (see utility model with publication number CN 207095896U) in the rotatory cover of electronic sampler, then, hold the handle of electronic sampler, pass the expander opening with the sample brush and stretch into the vagina in, and make the brush head stretch to cervical orifice department, press electric sampler's switch and sample operation switch with thumb or forefinger, the sample brush is twenty circles of autogiration under the drive of rotatory sheathed tube immediately, thereby make the flocking brush head of sample brush twenty circles of autogiration at cervical orifice, effectively acquire the cervical cast-off cell of capacity accurately. And accurately sampling the obtained cell sample, putting the cell sample into a cell preservation tube, and further detecting HPV, TCT and the like. The doctor uploads the cell detection results to the cervical disease management platform for subsequent diagnosis. The cervical disease management platform is a cervical disease cloud database, and through data sharing, a doctor expert can perform remote diagnosis on images and other detection results uploaded in the cervical disease cloud database at a computer terminal, inform the screened person of the diagnosis result, and send an abnormal referral notice if an abnormal result exists.

According to the cervical cancer accurate screening system, the image of the cervical region to be sampled is observed in real time through the digital electronic colposcope during sampling, so that the sampling is visualized, the digital colposcope is used for high-performance observation, the observation is not carried out by human eyes, the sampling accuracy and the accuracy of the cervical cancer accurate screening result are obviously improved, and the quality control standard in the cervical cancer accurate screening work is also ensured. Meanwhile, the cervical screening image stored by the cervical cancer accurate screening system can be replayed, so that each link of cervical cancer accurate screening work from the source can be traced, and the condition that the cervical cancer accurate screening result is influenced by improper operation in the sampling process is eliminated.

The colposcopy APP which is accessed from the port of the common user has a plurality of functions, including a medical record uploading function, a medical record inquiring function, a health education function, an expert consultation function, a referral reminding function, a repeated diagnosis reminding function and a result reminding function. The functions of the general user are described in detail as follows:

(1) Medical record uploading function: the user can upload the medical record to the cervical disease management platform by taking pictures or describing characters.

(2) Medical record query function: the user can inquire the cervical cancer accurate screening result record based on the system and the personal self-established medical record content uploaded to the cervical disease management platform by the user.

(3) And (4) health education function: the user can learn the published related knowledge of the cervical cancer through the WeChat public number.

(4) Expert consultation function: the user can conduct related medical guidance and doctor consultation on related contents through the cervical disease management platform.

(5) Referral reminding function: the user can be informed of the abnormal referral by WeChat when the cervical cancer is accurately screened.

(6) The function of the re-diagnosis reminding is as follows: after the user uploads the medical record of the user and fills in the corresponding re-diagnosis time, the system can inform the user of the re-diagnosis date through Wechat.

(7) And a result reminding function: accurate screening of users for cervical cancer can be informed by a WeChat of normal or abnormal result inquiry.

A colposcopy APP for a doctor user port to enter is provided with multiple functions, including an image acquisition function, a bar code or two-dimensional code recognition function, an image or detection result uploading function, a doctor diagnosis function, a referral function and a teaching live broadcasting function. The functions of the doctor user are described in detail as follows:

(1) An image acquisition function: the doctor uses colposcopy APP software to collect cervical pictures by combining with the digital electronic colposcope host.

(2) The bar code and two-dimensional code recognition function: the doctor can carry out the entry of test tube code or other information through scanning the sign indicating number.

(3) Image, result upload function: the acquired images or other detection results are uploaded to a cervical disease management platform by a doctor for diagnosis.

(4) The diagnosis function of the doctor: and the doctor computer terminal carries out remote diagnosis on the uploaded images and other results.

(5) The referral function is as follows: and the doctor transmits a referral notice of the abnormal result.

(6) The live function of teaching: the doctor can release the recorded teaching contents or the real-time live broadcast contents on the cervical disease management platform for the doctor to learn and use.

Example 1

The cervical cancer accurate screening system is tried in a secret state, cervical cancer screening work is carried out on women in a certain village and town, 2045-time free screening work is completed totally, and 829 cases of various gynecological diseases (40.5 percent, see figure 7) are preliminarily discovered by portable digital electronic colposcopy (VIA/VILI). Among them, the number of precancerous lesions and suspected cervical cancer was 93 (4.5%), 240 (11.7%) subclinical viral infection (SPI), and 496 (24.3%) chronic inflammation. During the screening process, the visualized accurately sampled sample is further used for HPV and TCT detection. The result of HPV detection revealed 240 cases of HPV infection (11.7%); after consultation of experts, the following results are determined: a total of 291 cases (14.2%) of patients with low grade/high grade/suspicious cancer seen under colposcopy, plus patients with high risk HPV positivity in other groups were included in the subsequent pathology confirmation; the positive rate of TCT is only 76 cases (3.7%), and the rate of missed detection is extremely high. Therefore, the VIA/VILI images of colposcopy, the HPV and TCT detection results of the visual sampling samples need to be integrated for integral judgment, as shown in FIG. 7, 1666 negative people (81.47%) are scientifically and definitely obtained through the cervical cancer integration screening of visual sampling + VIA/VILI + HPV + TCT, and the part of people need to be subjected to a new round of screening after 3 years according to the cervical cancer screening process published by the government of China, so that the screening cost is greatly saved. And other cases are subjected to pathological confirmation or half-year reexamination according to different conditions, so that the positive detection rate of cervical diseases is remarkably improved, and the omission ratio is greatly reduced.

The screening integration system of the invention also has the characteristic of high screening speed. In the screening process, about 2000 cases of human data can be completed within 3-4 days, and each device in each screening room can easily complete the screening work of 100 people per doctor one day. Therefore, the cervical cancer screening system plays an important role in cervical cancer screening.

The embodiments described above are specific and detailed, but should not be construed as limiting the scope of the invention. It should be noted that various changes and modifications can be made by those skilled in the art without departing from the spirit of the invention, and these changes and modifications are all within the scope of the invention. Therefore, the protection scope of the present patent should be subject to the appended claims.

Claims

1. An accurate cervical cancer screening system is characterized by comprising a digital electronic colposcope, a dilator, an intelligent terminal and a cervical disease management platform,

2. The accurate cervical cancer screening system of claim 1, wherein the digital electronic colposcope automatically takes pictures or videos of observed cervix uteri at regular time and automatically saves images of cervix uteri.

3. The accurate cervical cancer screening system of claim 2, wherein the automatic timed taking of the digital electronic colposcope records the entire acetic acid-iodine test in colposcopy.

4. The accurate cervical cancer screening system of claim 1, wherein the accurate sampling employs a disposable flocked sampling brush and a motorized sampler, the disposable flocked sampling brush being disposed within a rotating sleeve of a head of the motorized sampler.

5. The accurate cervical cancer screening system according to claim 1 or 4, wherein the samples obtained by accurate sampling are used for HPV and TCT detection.

6. The accurate cervical cancer screening system of claim 1, wherein the intelligent terminal comprises a tablet computer and a smart phone.

7. The cervical cancer accurate screening system of claim 1, wherein the colposcopy APP comprises an image acquisition module and a user interaction module, and the image acquisition module and the user interaction module are connected with the cervical disease management platform through a network.

8. The cervical cancer accurate screening system of claim 1, wherein the colposcopy APP has a plurality of login or registration ports including a general user port, a physician user port.

9. The cervical cancer accurate screening system of claim 8, wherein the general user port is provided with an electronic registration system, and the electronic registration system comprises self-entry of personal information by scanning a screening-dedicated two-dimensional code or entry of personal information by scanning an identification card.

10. The accurate cervical cancer screening system of claim 8, wherein the colposcopy APP entered from the common user port has a plurality of functions including a medical record uploading function, a medical record query function, a health education function, an expert consultation function, a referral prompting function, a review prompting function, and a result prompting function.

11. The accurate cervical cancer screening system of claim 8, wherein the colposcopy APP entered by the doctor user port has a plurality of functions, including an image acquisition function, a barcode or two-dimensional code recognition function, an image or detection result uploading function, a doctor diagnosis function, a referral function, and a live teaching function.