CN115676121B - Be used for prosthetic mesenchymal stem cell injection transportation of burn surface of a wound to preserve device - Google Patents
Be used for prosthetic mesenchymal stem cell injection transportation of burn surface of a wound to preserve device Download PDFInfo
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- CN115676121B CN115676121B CN202211712409.7A CN202211712409A CN115676121B CN 115676121 B CN115676121 B CN 115676121B CN 202211712409 A CN202211712409 A CN 202211712409A CN 115676121 B CN115676121 B CN 115676121B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W90/00—Enabling technologies or technologies with a potential or indirect contribution to greenhouse gas [GHG] emissions mitigation
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Abstract
The invention discloses a mesenchymal stem cell injection transportation and preservation device for burn wound repair. The device comprises a box body, a cover plate and a U-shaped plate; the lower end of the cover plate is fixedly provided with an expansion airbag, and the front end and the rear end of the cover plate are fixedly provided with contraction airbags communicated with the expansion airbag; the clearance shutoff between the top lateral wall that inflation gasbag and shrink gasbag can be lapped with the apron and store the chamber plays good sealed effect, prevents that the dust from entering into the storage chamber from the gap in, also can play the heat preservation effect simultaneously, prevents that the temperature in the storage chamber sharply rises or reduces. Two splint can play the tight fixed effect of clamp to stem cell injection storage box simultaneously to stem cell injection storage box under the unsettled state does not with box direct contact, can avoid the vibrations that the box produced directly to transmit stem cell injection storage box in, can play effectual buffering shock attenuation through telescopic link and spring setting in addition, improved transportation equipment's shock resistance performance, prevent that the cell of transportation is destroyed.
Description
Technical Field
The invention belongs to the technical field of mesenchymal stem cell injection transportation and preservation, and relates to a mesenchymal stem cell injection transportation and preservation device for burn wound repair.
Background
Mesenchymal Stem Cells (MSCs) are pluripotent stem cells derived from mesoderm, have biological characteristics such as self-renewal, multidirectional differentiation and immunoregulation, and become hot spots of tissue engineering and clinical treatment research, particularly have wide treatment prospects in the repair of burn wounds. The mesenchymal stem cells need to be prepared into preparations to be infused to patients after being prepared in a GMP clean workshop. How to ensure the cell survival rate is one of the key problems in clinical application. Most Cell Therapy Products (CTP) are injected or handled shortly after collection, but in some cases this may be delayed by as long as 48 hours. Research data indicate that long transport for up to 24 hours can create a significant disadvantage for stem cells, although cryopreserved MSCs may retain good differentiation potential, whereas transport of frozen cells is impractical for cell transplantation because freshly thawed MSCs may develop temporary dysfunction. The above problems present new challenges for the therapeutic use of current stem cells and for future commercial applications.
The existing transportation mode is characterized in that in the transportation process, the sealing effect between the stem cell injection storage box and the refrigerating box is poor, dust easily enters the insulating box, the oxygen and carbon dioxide concentrations in the refrigerating box cannot be guaranteed to be stable, and meanwhile the temperature of the refrigerating box is influenced. And in the transportation process, if jolt occurs, when the refrigerating box vibrates, longitudinal waves in the vertical direction are formed on the stem cell injection storage box, and the stem cell injection storage box vibrates along with the longitudinal waves, so that the stem cell injection oscillates. If stem cell injection storage box is directly placed in the fridge bottom, because can take place vibration many times between inertia stem cell injection storage box and the fridge, make the fridge to the vibration stack of stem cell injection storage box for the vibration wave that the injection in the stem cell injection storage box received is superposed, and then makes the vibration aggravation of injection. And resonance is easy to occur between the stem cell injection storage box and the refrigerating box, so that the oscillation of the injection is further aggravated, and the activity and the quality of the stem cells are damaged by violent oscillation.
In order to solve the problems, the invention provides a storage and transportation device with small influence on biological performances such as the survival rate and the proliferation capacity of stem cells according to the existing conditions of the current clinical application, and aims to provide an early-stage basic guarantee for improving the clinical treatment effect of the MSCs.
Disclosure of Invention
In order to solve the problems in the background art, the invention provides a mesenchymal stem cell injection transportation and preservation device for burn wound repair.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows: comprises that
The box body is characterized in that a sliding rod is fixedly arranged on the inner wall of the top end of the box body; a U-shaped plate is slidably sleeved on the sliding rod;
the cover plate is rotatably arranged on the U-shaped plate; the lower end of the cover plate is fixedly provided with an expansion airbag, and the front end and the rear end of the cover plate are fixedly provided with contraction airbags communicated with the expansion airbag; a first rubber layer is fixedly arranged at the upper end of the cover plate;
the opening of the box body is movably provided with a U-shaped frame; when the U-shaped frame moves, the cover plate is driven to rotate to shield the opening of the box body; a driving assembly for driving the U-shaped frame to act is arranged on the inner wall of the top end of the box body;
the clamping mechanism is arranged in the storage cavity of the box body; the clamping mechanism is in transmission connection with the U-shaped plate through a transmission assembly; when the clamping mechanism acts, the stem cell injection storage box is clamped and suspended.
Furthermore, a return spring is abutted between the U-shaped plate and the inner wall of the box body and sleeved on the sliding rod; a baffle is fixedly arranged at one end of the sliding rod close to the U-shaped plate;
a first torsion spring is fixedly arranged between the cover plate and the U-shaped plate.
Furthermore, the driving assembly comprises a bidirectional threaded rod, a motor and a sliding block fixedly arranged on the U-shaped frame;
a sliding groove is formed in the side wall of the top of the box body, and the motor is fixedly installed at one end of the sliding groove of the box body; a motor shaft of the motor is fixedly connected with one end of the bidirectional threaded rod; the bidirectional threaded rod is rotatably arranged in the chute; a first threaded hole matched with the bidirectional threaded rod is formed in the sliding block, and the sliding block is in threaded connection with the bidirectional threaded rod; the sliding block is in sliding fit with the sliding groove.
Further, the transmission assembly comprises a first chain wheel, a second chain wheel, a chain, a gear and a rack;
a first rotating shaft and a second rotating shaft are rotatably arranged on the inner wall of the box body;
the second chain wheel and the gear are fixedly sleeved on the first rotating shaft;
the first chain wheel is fixedly sleeved on the second rotating shaft;
the chain is wound on the first chain wheel and the second chain wheel;
the rack is fixedly arranged on the U-shaped plate and is meshed with the gear.
Furthermore, the clamping mechanism comprises a clamping plate, a second connecting block, an expansion rod, a spring and a first connecting block;
the first connecting block is fixedly sleeved on the second rotating shaft;
the telescopic rod is fixedly arranged between the first connecting block and the second connecting block;
the spring is sleeved on the telescopic rod and is fixedly connected between the first connecting block and the second connecting block;
the clamping plate is hinged with the second connecting block.
Furthermore, the elastic coefficients of the springs at the left side and the right side in the storage cavity are different.
Further, a second torsion spring is arranged between the clamping plate and the second connecting block, and a second rubber layer is arranged on the clamping plate.
Furthermore, the inner wall of the box body is provided with a yielding groove matched with the rack.
Further, the inflatable balloon and the deflatable balloon are both elastic.
Further, a temperature measuring instrument, an oxygen concentration measuring instrument and a carbon dioxide concentration measuring instrument are arranged in the box body; a display and an alarm are arranged on the outer side of the box body; the temperature measuring instrument, the oxygen concentration measuring instrument and the carbon dioxide concentration measuring instrument are electrically connected with the display through the controller; the controller is also electrically connected with the alarm;
and an oxygen input interface and a carbon dioxide input interface are arranged on the box body.
Compared with the prior art, the invention has the following beneficial effects: after the two cover plates are closed, the expanded air bag and the contracted air bag can plug the gap between the cover plates and the side wall of the top of the storage cavity, and a good sealing effect is achieved. Prevent like this that the dust from entering into the storage chamber from the gap, prevent that the great change of the concentration of storing intracavity oxygen and carbon dioxide from taking place, also can play the heat preservation effect simultaneously, prevent that the temperature in the storage chamber from sharply rising or reducing. The invention can prevent pollution, and can ensure the stability of the temperature and the concentration of oxygen and carbon dioxide in the storage cavity, thereby ensuring the vitality and the quality of stem cells.
Two splint can play the tight fixed effect of clamp to stem cell injection storage box simultaneously to stem cell injection storage box under the unsettled state does not contact with box direct, can avoid the vibrations that the box produced directly to transmit in the stem cell injection storage box, can play effectual buffering shock attenuation through telescopic link and spring setting in addition, improved transportation equipment's shock resistance performance, prevent that the stem cell of transportation from being destroyed, further assurance stem cell's vitality and quality.
Drawings
FIG. 1 is an external structural view of the present invention;
FIG. 2 is a schematic view of the internal structure of the present invention;
FIG. 3 is an enlarged view of portion A of FIG. 2 according to the present invention;
FIG. 4 is a partial exploded view of the present invention;
FIG. 5 is a schematic view of the connection of the U-shaped frame and the slider of the present invention;
FIG. 6 is a schematic view of the structure of the cover plate of the present invention;
fig. 7 is a schematic view showing the connection of the stopper to the stem cell injection solution storage case according to the present invention.
In the figure: 1. a box body; 2. a storage chamber; 3. a cover plate; 4. inflating the balloon; 5. contracting the air bag; 6. a first rubber layer; 7. a U-shaped plate; 8. a slide bar; 9. a baffle plate; 10. a U-shaped frame; 11. a slider; 12. a chute; 13. a bidirectional threaded rod; 14. mounting grooves; 15. a first connection block; 16. a telescopic rod; 17. a second connecting block; 18. a spring; 19. a splint; 20. a second sprocket; 21. a first sprocket; 22. a chain; 23. a gear; 24. a rack; 25. a yielding groove; 26. a return spring; 27. a stopper; 28. stem cell injection storage boxes; 29. a temperature measuring instrument; 30. an oxygen concentration measuring instrument; 31. a carbon dioxide concentration measuring instrument; 32. a display; 33. an alarm; 34. an oxygen input interface; 35. a carbon dioxide input interface.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1 to 7, the technical solution adopted by the present invention is as follows: a mesenchymal stem cell injection transportation and preservation device for burn wound repair, including box 1, the upper end opening part symmetry of box 1 is equipped with two apron 3. The lower extreme of apron 3 sets firmly expansion airbag 4, and the front and back end of apron 3 all sets firmly shrink gasbag 5. The contracting balloon 5 is communicated with the expanding balloon 4 through a trachea. The upper end of the cover plate 3 is fixedly provided with a first rubber layer 6. The inflatable balloon 4 and the deflatable balloon 5 are both elastic and have the characteristic of self-recovery.
When the cover plate 3 shields the opening of the box body 1, gas is filled in the expansion airbag 4 and the contraction airbag 5, and a gap between the cover plate 3 and the side wall of the top of the box body 1 is sealed. The first rubber layers 6 on the two cover plates 3 are pressed and attached together. Through inflation airbag 4 and shrink gasbag 5, first rubber layer messenger box 1 and apron 3 between reach good sealed effect, prevent that the dust from entering into storage chamber 2 from the gap, prevent that the concentration of oxygen and carbon dioxide in the storage chamber 2 from taking place great change, also can play the heat preservation effect simultaneously, prevent that the temperature in the storage chamber from sharply rising or reducing. The device can prevent pollution, guarantees the purpose that the temperature in the storage chamber and the concentration of oxygen and carbon dioxide are stable, and then guarantees the vitality and the quality of stem cells.
As shown in fig. 2, the cover plate 3 is rotatably connected to the case 1 by a U-shaped plate 7. Two slide bars 8 are fixedly arranged at two ends of the inner wall of the left side and two ends of the inner wall of the right side of the top end of the box body 1. The U-shaped plates 7 are arranged on the left side and the right side of the top end of the box body 1 respectively. The U-shaped plate 7 is sleeved on the sliding rod 8 in a sliding manner, and the sliding rod 8 is sleeved with a return spring 26. One end of the return spring 26 is fixed on the U-shaped plate 7, and the other end is fixed on the inner wall of the box body 1. A baffle 9 is fixedly arranged at one end of the sliding rod 8 close to the U-shaped plate 7. The cover plate 3 is rotatably connected with the corresponding U-shaped plate 7. A first torsion spring is fixedly arranged between the cover plate 3 and the U-shaped plate 7.
The opening at the upper end of the box body 1 is provided with two U-shaped frames 10, and the two U-shaped frames 10 are respectively matched with the corresponding cover plates 3. The U-shaped frame 10 drives the cover plate 3 to move, so that the cover plate 3 covers the opening at the upper end of the box body 1. The inner wall of the box body 1 is provided with a driving component for driving the U-shaped frame 10 to act.
The case 1 has a storage chamber 2. The storage cavity 2 is internally provided with a clamping mechanism which is in transmission connection with the U-shaped plate 7 through a transmission assembly. When the U-shaped plate 7 slides along the slide bar 8, the transmission assembly drives the clamping mechanism to act, so that the stem cell injection liquid storage box 28 placed in the storage cavity 2 is clamped and fixed, and is suspended in the storage cavity 2.
Stem cell injection storage box 28 unsettled setting, not with box 1 direct contact, like this when box 1 takes place the vibration, stem cell injection storage box 28 can not and the box 1 between take place vibration many times, can not make the vibration wave stack of injection, and then alleviateed the amplitude of stem cell injection. The suspension arrangement also reduces the probability of resonance between the stem cell injection and the box body 1, further reduces the probability of violent oscillation of the stem cell injection, and further increases the protection of the stem cell injection.
The driving component comprises a bidirectional threaded rod 13 and a motor.
The opposite inner walls of the top of the box body 1 are provided with sliding chutes 12. Two bidirectional threaded rods 13 are provided, and each bidirectional threaded rod 13 is rotatably arranged in a corresponding sliding groove 12.
Two motors are provided, and each motor is fixedly arranged at one end of the sliding chute 12 corresponding to the box body 1; the motor shaft of the motor is fixedly connected with one end of the corresponding bidirectional threaded rod 13.
The two ends of the U-shaped frame 10 are fixedly provided with sliding blocks 11, the sliding blocks 11 are provided with first threaded holes matched with the bidirectional threaded rods 13, and the two sliding blocks 11 are respectively in threaded connection with the corresponding bidirectional threaded rods 13. The U-shaped frame 10 is in sliding fit with the sliding groove 12 through the sliding block 11.
When the motor works, the motor drives the bidirectional threaded rod 13 to rotate, and the bidirectional threaded rod 13 drives the sliding block 11 to move along the sliding groove 12, so that the U-shaped frame 10 is driven to move along the direction of the sliding groove 12. The U-shaped frame 10 drives the cover plate 3 to rotate. The cover plates 3 on the left and right sides rotate clockwise and anticlockwise respectively. Due to the resistance of the first torsion spring, the two cover plates 3 rotate smoothly under the action of the U-shaped frame 10.
The U-shaped frame 10 presses the deflated airbag 5 during movement, and the position where the U-shaped frame 10 contacts the deflated airbag 5 cannot pass through the gas, so that the U-shaped frame 10 divides the deflated airbag 5 into two parts. As the cover 3 is rotated, the inflating bladder 4 comes closer to and contacts the inner wall of the case 1. The expansion airbag 4 is pressed by the cover plate 3 and the inner wall of the box body 1, so that the gas in the expansion airbag 4 is conveyed into the contraction airbag 5, and the contraction airbag 5 is gradually expanded and enlarged. Since the U-shaped frame 10 divides the deflated bladder 5 into two parts, the gas of the inflated bladder 4 can flow only into the part of the deflated bladder 5 near the inflated bladder 4, and the other part of the deflated bladder 5 will not expand much due to the obstruction of the U-shaped frame 10, so that the U-shaped frame 10 can move smoothly. Meanwhile, the expanded part of the contraction air bag 5 is filled in the gap between the cover plate 3 and the box body 1, and a good sealing effect is achieved.
When the two cover plates 3 touch each other, the cover plates 3 on the left and right sides will continue to rotate clockwise and counterclockwise, and the cover plates 3 on the left and right sides will move to the left and right ends, respectively. The corresponding U-shaped plate 7 is driven to move along the slide bar 8 to the direction close to the inner wall of the box body 1, thereby compressing the return spring 26. One end of the cover plate 3 provided with the expansion air bag 4 is gradually close to the inner wall of the box body 1. Finally, the two cover plates 3 are moved to the horizontal state, and the two U-shaped frames 10 are attached to each other. The inflatable air bag 4 is pressed by the cover plate 3 and the inner wall of the box body 1 to seal the gap between the cover plate 3 and the inner wall of the box body 1. The gap between the cover plate 3 and the inner walls of the case 1 on the left and right sides is sealed. The inflatable air bag 4 is pressed by the cover plate 3 and the inner wall of the case 1, and the inflatable air bag 5 is kept in an inflated state. The inflated contraction air bag 5 is acted by the inflation air bag 4, the cover plate 3 and the inner wall of the box body 1, and fills the gap between the front end and the rear end of the cover plate 3 and the inner wall of the box body 1. At this time, the first rubber layers 6 on the two cover plates 3 are pressed and attached together. So that the two cover plates 3 are sealed therebetween.
The two transmission assemblies are respectively matched with the corresponding U-shaped plates 7. The opposite inner walls of the box body 1 are symmetrically provided with mounting grooves 14. The two transmission assemblies are mounted in the corresponding mounting slots 14.
As shown in fig. 3, the transmission assembly includes a first sprocket 21, a second sprocket 20, a chain 22, a gear 23, and a rack 24. The inner wall of the box body 1 is rotatably provided with a first rotating shaft and a second rotating shaft. The first chain wheel 21 and the gear 23 are fixedly sleeved on the first rotating shaft. The second chain wheel 20 is fixedly sleeved on the second rotating shaft. A chain 22 is wound around the first sprocket 21 and the second sprocket 20. The rack 24 is fixed on the U-shaped plate 7 and meshed with the gear 23. The inner wall of the box body 1 is provided with a abdicating groove 25 matched with the rack 24. The relief groove 25 provides a space for movement of the rack 24.
The two clamping mechanisms are respectively matched with the corresponding transmission assemblies.
The clamping mechanism comprises a clamping plate 19, a second connecting block 17, an expansion rod 16, a spring 18 and a first connecting block 15.
The first connecting block 15 is fixedly sleeved on the second rotating shaft.
The telescopic rod 16 is fixedly arranged between the first connecting block 15 and the second connecting block 17.
The spring 18 is sleeved on the telescopic rod 16. The spring 18 has a shock absorbing function when compressed and also has a function of returning the telescopic rod 16. The springs 18 in the left and right sides of the storage chamber have different elastic coefficients.
The clamping plate 19 is hinged to the second connecting block 17. And a second torsion spring is fixedly arranged between the clamping plate 19 and the second connecting block 17, and the second torsion spring enables the clamping plate 19 to keep a vertical state. The clamping plate 19 is fixedly provided with a second rubber layer. The second rubber layer has the function of skid resistance, so that the clamping plate 19 can clamp the stem cell injection storage box 28 more firmly.
The stem cell injection storage box 28 is provided with a stopper 27 which is matched with the clamping plate 19. When the stem cell injection solution storage cassette 28 is put into the storage chamber 2 of the housing 1, the clamp plate 19 is put under the stopper 27.
In the process of the deviation movement of the two U-shaped plates 7, the U-shaped plates 7 drive the rack 24 to move towards the receding groove 25, the rack 24 drives the gear 23 to rotate, so that the first rotating shaft rotates, the first chain wheel 21 rotates, the chain 22 drives the second chain wheel 20 to rotate, the second rotating shaft further rotates, the first connecting block 15 rotates, and the telescopic rod 16, the second connecting block 17 and the clamping plate 19 rotate simultaneously. The clamping plates 19 on the left and right sides rotate counterclockwise and clockwise, respectively. As the clamp plate 19 is rotated, the clamp plate 19 is gradually brought close to and abutted against the stem cell injection solution storage cassette 28, and the bottom surfaces of the stoppers 27 at both sides of the stem cell injection solution storage cassette 28 are brought into contact with the top surface of the clamp plate 19. Then, during the process of continuing to rotate the telescopic rod 16, the clamping plate 19 gradually clamps the stem cell injection storage box 28 and drives the stem cell injection storage box 28 to move upwards. In the process, the clamping plate 19 is kept in a vertical state, and the second connecting block 17 rotates around the hinge joint of the second connecting block 17 and the clamping plate 19. Finally, the telescopic rod 16 rotates to the horizontal state, and the stem cell injection storage box 28 is in a suspended state. In the process, the telescopic rod 16 is gradually shortened, and the spring 18 is compressed to have elastic potential energy.
Stem cell injection storage box 28 under this state does not with box 1 direct contact, can avoid the vibrations that box 1 produced directly to transmit stem cell injection storage box 28 in, can play effectual buffering shock attenuation through telescopic link 16 and spring 18 moreover, has improved the shock resistance performance of transportation equipment, prevents that the cell of transportation from being destroyed.
Since the tank 1 is transported, the generated jolts mainly occur in the vertical direction. Vibration is generated between the box body 1 and the stem cell injection liquid storage box 28 in the vertical direction, namely, the stem cell injection liquid storage box 28 generates vertical longitudinal waves to the stem cell injection liquid. Since the elastic coefficients of the springs 18 on both sides of the stem cell injection solution storage box 28 are different, when the box body 1 vibrates, the elastic deformation amounts of the two springs 18 are different during the up-down vibration of the stem cell injection solution storage box 28. Make stem cell injection storage box 28 produce in the left and right directions and remove, prevent that the shock wave that the stem cell injection formed from putting at stem cell injection storage box 28 central point and producing the stack, avoided causing the acutely to vibrate of stem cell injection. In addition, the energy generated by the vibration in the vertical direction forms a horizontal movement to the stem cell injection storage box 28, so that the energy of the stem cell injection storage box 28 in the vertical direction is reduced, the amplitude of the longitudinal wave of the stem cell injection in the vertical direction is further reduced, and the protection of the stem cell injection is increased.
The box body 1 is a medicine refrigerating box, and is internally provided with a temperature measuring instrument 29, an oxygen concentration measuring instrument 30 and a carbon dioxide concentration measuring instrument 31. The outer side of the box body 1 is provided with a display 32 and an alarm 33. The temperature measuring instrument 29, the oxygen concentration measuring instrument 30 and the carbon dioxide concentration measuring instrument 31 are all electrically connected with the display 32 through the controller. The controller is also electrically connected to an alarm 33. The box body 1 is provided with an oxygen input interface 34 and a carbon dioxide input interface 35.
The display 32 can acquire data information on the temperature in the case 1 and the concentrations of oxygen and carbon dioxide at any time. And when the temperature in the box body 1 reaches the critical value of 4 ℃, the alarm 33 can give an alarm for reminding. The alarm 33 also gives an alarm when the concentration of oxygen or carbon dioxide in the tank 1 reaches a critical value. Then, the worker inputs oxygen into the tank 1 through the oxygen input port 34 or inputs carbon dioxide into the tank 1 through the carbon dioxide input port 35 as necessary.
The working principle is as follows: in the initial state, the two cover plates 3 are in the vertical state, and the return spring 26 is in the compressed state and has a certain elastic potential energy, but does not reach the limit value of compression. The U-shaped plate 7 abuts against one side of the baffle 9 under the elastic action of the return spring 26. Both the inflated airbag 4 and the deflated airbag 5 are in a natural state, that is, the inflated airbag 4 is in an inflated state, and the deflated airbag 5 is in a flat state. Two U-shaped frames 10 are located between the cover plate 3 and the inner wall of the case 1, respectively. The telescopic rod 16 is inclined downwards and is in an extended state, and the clamping plate 19 is in a vertical state under the action of the second torsion spring.
The stem cell injection solution storage cassette 28 and the coolant are placed in the storage chamber 2 with the stem cell injection solution storage cassette 28 between the clamping plates 19. The stopper 27 of the stem cell injection storage box 28 is located above the top of the clamping plate 19.
The motor is started, the motor drives the bidirectional threaded rod 13 to rotate, and the bidirectional threaded rod 13 drives the sliding block 11 to move along the sliding groove 12, so that the U-shaped frame 10 is driven to move along the direction of the sliding groove 12. The U-shaped frame 10 drives the cover plate 3 to rotate. The cover plates 3 on the left and right sides rotate clockwise and anticlockwise respectively. Due to the resistance of the first torsion spring, the two cover plates 3 rotate smoothly under the action of the U-shaped frame 10. The elastic potential energy of the first torsion spring will gradually increase with the movement of the cover plate 3. The U-shaped frame 10 presses the deflated bladder 5 during movement, and the position where the U-shaped frame 10 contacts the deflated bladder 5 cannot pass through, so the U-shaped frame 10 divides the deflated bladder 5 into two parts. As the cover 3 is rotated, the inflating airbag 4 comes close to and contacts the inner wall of the case 1. The expansion airbag 4 is pressed by the cover plate 3 and the inner wall of the case 1, so that the gas in the expansion airbag 4 is conveyed into the contraction airbag 5, and the contraction airbag 5 is gradually expanded. Since the U-shaped frame 10 divides the deflated bladder 5 into two parts, the gas of the inflated bladder 4 can flow only into the part of the deflated bladder 5 near the inflated bladder 4, and the other part of the deflated bladder 5 is not inflated to be large due to the obstruction of the U-shaped frame 10, so that the U-shaped frame 10 can move smoothly. Meanwhile, the expanded part of the contraction air bag 5 is filled in the gap between the cover plate 3 and the box body 1, and a good sealing effect is achieved.
When the two cover plates 3 touch each other, the cover plates 3 on the left and right sides will continue to rotate clockwise and counterclockwise, and the cover plates 3 on the left and right sides will move to the left and right ends, respectively. The corresponding U-shaped plate 7 is driven to move along the sliding rod 8 to the direction close to the inner wall of the box body 1, thereby compressing the return spring 26. One end of the cover plate 3 provided with the inflatable air bag 4 is gradually close to the inner wall of the box body 1. Finally, the two cover plates 3 are moved to the horizontal state, and the two U-shaped frames 10 are attached to each other. The inflatable air bag 4 is pressed by the cover plate 3 and the inner wall of the box body 1 to seal the gap between the cover plate 3 and the inner wall of the box body 1. The gap between the cover plate 3 and the inner walls of the case 1 on the left and right sides is sealed. The inflatable air bag 4 is pressed by the cover plate 3 and the inner wall of the box body 1, so that the inflatable air bag 5 keeps an inflated state. The inflated and deflated air bag 5 is acted by the inflated air bag 4, the cover plate 3 and the inner wall of the box body 1 to fill the gap between the front end and the rear end of the cover plate 3 and the inner wall of the box body 1. At this time, the first rubber layers 6 on the two cover plates 3 are pressed and attached together. So that the two cover plates 3 are sealed therebetween. The motor is then turned off.
In the process of the deviation movement of the two U-shaped plates 7, the U-shaped plates 7 drive the rack 24 to move towards the direction of the abdicating groove 25, the rack 24 drives the gear 23 to rotate, so that the first rotating shaft rotates, the first chain wheel 21 rotates, the second chain wheel 20 rotates through the chain 22, the second rotating shaft further rotates, the first connecting block 15 rotates, and the telescopic rod 16, the second connecting block 17 and the clamping plate 19 rotate simultaneously. The clamping plates 19 on the left and right sides rotate counterclockwise and clockwise respectively. As the clamp plate 19 is rotated, the clamp plate 19 comes close to and abuts the stem cell injection solution storage cassette 28, and the bottom surfaces of the stoppers 27 at both sides of the stem cell injection solution storage cassette 28 come into contact with the top surface of the clamp plate 19. Then, during the process of continuing to rotate the telescopic rod 16, the clamping plate 19 gradually clamps the stem cell injection storage box 28 and drives the stem cell injection storage box 28 to move upwards. In the process, the clamping plate 19 is kept in a vertical state, and the second connecting block 17 rotates around the hinge joint of the second connecting block 17 and the clamping plate 19. Finally, the telescopic rod 16 rotates to the horizontal state, and the stem cell injection storage box 28 is in a suspended state. In the process, the telescopic rod 16 is gradually shortened, and the spring 18 is compressed to have elastic potential energy. Stem cell injection storage box 28 under this state does not with box 1 direct contact, can avoid the vibrations that box 1 produced directly to transmit to stem cell injection storage box 28 in, can play effectual buffering shock attenuation through telescopic link 16 and spring 18 moreover, improved the shock resistance performance of transportation equipment, prevent that the cell of transportation from being destroyed.
When the stem cell injection storage box 28 needs to be opened, the motor is started, and the motor drives the bidirectional threaded rod 13 to rotate, so that the two U-shaped frames 10 move away from each other. When the U-shaped frame 10 moves away from the air bag, the deflated airbag 5 is pressed, the air in the deflated airbag 5 flows into the inflated airbag 4, and the inflated airbag 4 is further inflated.
Meanwhile, an upward pulling force is applied to the cover plates 3, so that the cover plates 3 on the left side and the right side rotate anticlockwise and clockwise respectively. Thereafter, the cover plate 3 is gradually restored to the original state by the first torsion spring elastic potential energy as the U-shaped frame 10 moves. In the process, the return spring 26 pushes the U-shaped plate 7 to slide towards one end close to the baffle 9. The clearance between the left end and the right end of the cover plate 3 and the inner wall of the box body 1 is gradually enlarged, and the expansion air bag 4 is restored to the original state, so that the gas in the contraction air bag 5 enters the expansion air bag 4. When the U-shaped frame 10 is restored to the initial position and both the cover plates 3 are in the vertical state, the inflated air bag 4 and the deflated air bag 5 are restored at the same time, and the U-shaped plate 7 abuts against the baffle 9.
When U-shaped board 7 removed, it removes to drive rack 24, rack 24 drives gear 23 and rotates, drive first sprocket 21 through first pivot and rotate, drive second sprocket 20 through chain 22 and rotate, further drive first connecting block 15 through the second pivot and rotate, thereby make telescopic link 16, second connecting block 17, splint 19 rotate, telescopic link 16 becomes the tilt state by the horizontality gradually, under the effect of spring 18, telescopic link 16 extends gradually, make splint 19 keep the clamping state to stem cell injection storage box 28. And the telescopic rod 16 drives the stem cell injection storage box 28 to gradually move downwards until the stem cell injection storage box 28 is gradually placed at the bottom of the box body 1, and at the moment, the spring 18 restores to a natural state. Then the telescopic rod 16 continues to rotate, and the clamping plate 19 gradually loses the clamping force on the stem cell injection storage box 28. The stem cell injection solution storage cassette 28 can be smoothly taken out of the casing 1.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes in the embodiments and/or modifications of the invention can be made, and equivalents and modifications of some features of the invention can be made without departing from the spirit and scope of the invention.
Claims (8)
1. A mesenchymal stem cell injection transportation of being used for burn wound to restore keeps device which characterized in that includes:
the box body (1), a slide bar (8) is fixedly arranged on the inner wall of the top end of the box body (1); a U-shaped plate (7) is slidably sleeved on the sliding rod (8);
the cover plate (3), the said cover plate (3) is installed on U-shaped plate (7) rotatably; the lower end of the cover plate (3) is fixedly provided with an expansion air bag (4), and the front end and the rear end of the cover plate (3) are respectively fixedly provided with a contraction air bag (5) communicated with the expansion air bag (4); a first rubber layer (6) is fixedly arranged at the upper end of the cover plate (3);
the opening of the box body (1) is movably provided with the U-shaped frame (10); when the U-shaped frame (10) moves, the cover plate (3) is driven to rotate to shield the opening of the box body (1); a driving assembly for driving the U-shaped frame (10) to act is arranged on the inner wall of the top end of the box body (1);
the clamping mechanism is arranged in the storage cavity (2) of the box body (1); the clamping mechanism is in transmission connection with the U-shaped plate (7) through a transmission assembly; when the clamping mechanism acts, the stem cell injection storage box (28) is clamped, and the stem cell injection storage box (28) is suspended;
the transmission assembly comprises a first chain wheel (21), a second chain wheel (20), a chain (22), a gear (23) and a rack (24); a first rotating shaft and a second rotating shaft are rotatably arranged on the inner wall of the box body (1); the second chain wheel (20) and the gear (23) are fixedly sleeved on the first rotating shaft; the first chain wheel (21) is fixedly sleeved on the second rotating shaft; a chain (22) is wound on the second chain wheel (20) and the first chain wheel (21); the rack (24) is fixedly arranged on the U-shaped plate (7) and is meshed with the gear (23);
the clamping mechanism comprises a clamping plate (19), a second connecting block (17), an expansion rod (16), a spring (18) and a first connecting block (15); the first connecting block (15) is fixedly sleeved on the second rotating shaft; the telescopic rod (16) is fixedly arranged between the first connecting block (15) and the second connecting block (17); the spring (18) is sleeved on the telescopic rod (16) and is fixedly connected between the first connecting block (15) and the second connecting block (17); the clamping plate (19) is hinged with the second connecting block (17).
2. The mesenchymal stem cell injection transportation and preservation device for burn wound repair according to claim 1, wherein: a return spring (26) is abutted between the U-shaped plate (7) and the inner wall of the box body (1), and the return spring (26) is sleeved on the sliding rod (8); a baffle (9) is fixedly arranged at one end of the sliding rod (8) close to the U-shaped plate (7);
a first torsion spring is fixedly arranged between the cover plate (3) and the U-shaped plate (7).
3. The mesenchymal stem cell injection transportation and preservation device for burn wound repair according to claim 1, wherein: the driving component comprises a bidirectional threaded rod (13), a motor and a sliding block (11) fixedly arranged on the U-shaped frame (10);
a sliding groove (12) is formed in the side wall of the top of the box body (1), and the motor is fixedly installed at one end of the sliding groove (12) of the box body (1); a motor shaft of the motor is fixedly connected with one end of the bidirectional threaded rod (13); the bidirectional threaded rod (13) is rotatably arranged in the chute (12); a first threaded hole matched with the bidirectional threaded rod (13) is formed in the sliding block (11), and the sliding block (11) is in threaded connection with the bidirectional threaded rod (13); the sliding block (11) is in sliding fit with the sliding groove (12).
4. The mesenchymal stem cell injection transportation and preservation device for burn wound repair according to claim 1, wherein: the left and right springs (18) in the storage chamber (2) have different elastic coefficients.
5. The transportation and preservation device for mesenchymal stem cell injection for burn wound repair according to claim 1, characterized in that: a second torsion spring is arranged between the clamping plate (19) and the second connecting block (17); and a second rubber layer is arranged on the clamping plate (19).
6. The mesenchymal stem cell injection transportation and preservation device for burn wound repair according to claim 1, wherein: the inner wall of the box body (1) is provided with a yielding groove (25) matched with the rack (24).
7. The mesenchymal stem cell injection transportation and preservation device for burn wound repair according to claim 1, wherein: the inflatable air bag (4) and the contractible air bag (5) both have elasticity.
8. The mesenchymal stem cell injection transportation and preservation device for burn wound repair according to claim 1, wherein: a temperature measuring instrument (29), an oxygen concentration measuring instrument (30) and a carbon dioxide concentration measuring instrument (31) are arranged in the box body (1); a display (32) and an alarm (33) are arranged on the outer side of the box body (1); the temperature measuring instrument (29), the oxygen concentration measuring instrument (30) and the carbon dioxide concentration measuring instrument (31) are electrically connected with the display (32) through the controller; the controller is also electrically connected with an alarm (33);
an oxygen input interface (34) and a carbon dioxide input interface (35) are arranged on the box body (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211712409.7A CN115676121B (en) | 2022-12-30 | 2022-12-30 | Be used for prosthetic mesenchymal stem cell injection transportation of burn surface of a wound to preserve device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211712409.7A CN115676121B (en) | 2022-12-30 | 2022-12-30 | Be used for prosthetic mesenchymal stem cell injection transportation of burn surface of a wound to preserve device |
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| CN115676121B true CN115676121B (en) | 2023-03-10 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE202007010226U1 (en) * | 2007-07-23 | 2008-12-04 | Agor Gmbh & Co. Kg | Transport and / or display unit for a wiper blade of vehicles |
| DE102014200879A1 (en) * | 2014-01-20 | 2015-07-23 | Robert Bosch Gmbh | Transport container for lithium batteries |
| AT519320A1 (en) * | 2016-11-08 | 2018-05-15 | Ing Sumetzberger Gmbh | Pneumatic tube sleeve |
| US10155607B2 (en) * | 2016-11-21 | 2018-12-18 | Foreshore Tram & Moorage Ltd. | Carrying apparatus with internal suspension |
| CN110498112B (en) * | 2019-08-20 | 2020-10-13 | 中国人民解放军陆军军医大学第一附属医院 | Cell transportation equipment |
| CN214650142U (en) * | 2021-04-28 | 2021-11-09 | 吉林工程技术师范学院 | Storage device of biochip |
| CN216003497U (en) * | 2021-09-28 | 2022-03-11 | 平顶山神马工程塑料科技发展有限公司 | Nylon chip transfer box |
| CN114229202A (en) * | 2021-12-20 | 2022-03-25 | 闫文所 | Conveying device for production of water pump motor driver and conveying method thereof |
| CN114772035A (en) * | 2022-04-15 | 2022-07-22 | 江苏欣迈豫龙科技有限公司 | Intelligent stacking and placing device for manufacturing production |
| CN217893601U (en) * | 2022-07-21 | 2022-11-25 | 广州市番尔德金属制品有限公司 | Shock absorption box |
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