CN115671252A - Microcapsule with nano zinc oxide as carrier for improving gastrointestinal tract health of piglets - Google Patents
Microcapsule with nano zinc oxide as carrier for improving gastrointestinal tract health of piglets Download PDFInfo
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- CN115671252A CN115671252A CN202211269584.3A CN202211269584A CN115671252A CN 115671252 A CN115671252 A CN 115671252A CN 202211269584 A CN202211269584 A CN 202211269584A CN 115671252 A CN115671252 A CN 115671252A
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- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 title claims abstract description 97
- 239000003094 microcapsule Substances 0.000 title claims abstract description 66
- 239000011787 zinc oxide Substances 0.000 title claims abstract description 49
- 230000036541 health Effects 0.000 title claims abstract description 31
- 210000001035 gastrointestinal tract Anatomy 0.000 title claims abstract description 29
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 84
- 239000003814 drug Substances 0.000 claims abstract description 63
- 238000002360 preparation method Methods 0.000 claims abstract description 44
- 239000006041 probiotic Substances 0.000 claims abstract description 41
- 235000018291 probiotics Nutrition 0.000 claims abstract description 41
- 239000000463 material Substances 0.000 claims abstract description 38
- 150000001875 compounds Chemical class 0.000 claims abstract description 35
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- 239000011782 vitamin Substances 0.000 claims abstract description 33
- 229940088594 vitamin Drugs 0.000 claims abstract description 33
- 108010016626 Dipeptides Proteins 0.000 claims abstract description 28
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 28
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000004472 Lysine Substances 0.000 claims abstract description 28
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 28
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract description 28
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- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000011669 selenium Substances 0.000 claims abstract description 28
- 229910052711 selenium Inorganic materials 0.000 claims abstract description 28
- MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 claims abstract description 28
- 239000002994 raw material Substances 0.000 claims abstract description 13
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims abstract description 11
- 230000002496 gastric effect Effects 0.000 claims abstract description 7
- LCQLHJZYVOQKHU-VKHMYHEASA-N carglumic acid Chemical compound NC(=O)N[C@H](C(O)=O)CCC(O)=O LCQLHJZYVOQKHU-VKHMYHEASA-N 0.000 claims description 54
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 27
- 229940038879 chelated zinc Drugs 0.000 claims description 27
- 229910052802 copper Inorganic materials 0.000 claims description 27
- 239000010949 copper Substances 0.000 claims description 27
- 238000000227 grinding Methods 0.000 claims description 20
- 238000002156 mixing Methods 0.000 claims description 20
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 20
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 238000011049 filling Methods 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 10
- 235000018977 lysine Nutrition 0.000 claims description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 5
- 239000000839 emulsion Substances 0.000 claims description 5
- 238000007873 sieving Methods 0.000 claims description 5
- 238000003860 storage Methods 0.000 claims description 5
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 239000004246 zinc acetate Substances 0.000 claims description 5
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 4
- 244000063299 Bacillus subtilis Species 0.000 claims description 4
- 235000014469 Bacillus subtilis Nutrition 0.000 claims description 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 4
- 241000186605 Lactobacillus paracasei Species 0.000 claims description 4
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 4
- 229930003268 Vitamin C Natural products 0.000 claims description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 4
- 235000019155 vitamin A Nutrition 0.000 claims description 4
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
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- 229940046009 vitamin E Drugs 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- 241000628997 Flos Species 0.000 claims description 2
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- 239000010135 fructus aurantii immaturus Substances 0.000 claims description 2
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 7
- 210000000936 intestine Anatomy 0.000 abstract description 7
- 210000002784 stomach Anatomy 0.000 abstract description 7
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- 239000013522 chelant Substances 0.000 abstract 2
- -1 copper N-carbamylglutamate Chemical compound 0.000 abstract 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a microcapsule which is used for improving the gastrointestinal tract health of piglets and takes nano zinc oxide as a carrier, the outer wall material of the microcapsule is nano zinc oxide, and the medicament wrapped in the microcapsule comprises the following raw materials in parts by weight: the invention relates to a feed additive, which comprises sweet potatoes, lysine, a probiotic preparation, sodium butyrate, glutamine dipeptide, a traditional Chinese medicine compound, apple pomace, glucose, selenium yeast, vitamins, citric acid, copper N-carbamylglutamate chelate and zinc N-carbamylglutamate chelate. The microcapsule taking the nano zinc oxide as the carrier for improving the gastrointestinal health of the piglets can be taken by the piglets for a long time by adopting a mode of combining a traditional Chinese medicine preparation and probiotics to improve the gastrointestinal health of the piglets, well achieves the aim of ensuring the intestines and stomach of the piglets to be more healthy by adopting the traditional Chinese medicine to promote the intestines and stomach, the probiotics and the synergistic effect of other nutritional ingredients, greatly improves the treatment effect and realizes the purpose of prolonging the relapse period of the intestinal tract diseases of the piglets.
Description
Technical Field
The invention relates to the technical field of breeding medicaments, in particular to a microcapsule which is used for improving the gastrointestinal tract health of piglets and takes nano zinc oxide as a carrier.
Background
With the development of the pig raising industry, the operation of pig farms tends to become specialized more and more. The separation of sow farms and nursery-finishing farms makes the trading of piglets more and more frequent. However, because piglets have imperfect development of the digestive system and the immune system, stress reaction of piglets is often caused by the change of nutrition supply and environment, so that the feed intake, the growth performance, the intestinal health and the like are reduced, and the phenomena of low daily gain, diarrhea, serious patients and even death occur. The existing means for relieving the stress of the piglets mainly reduces the possibility of infection diseases of the piglets by adding antibiotics in large dose into feed or drinking water, but cannot fundamentally solve the problems of intestinal tract injury, immunosuppression and growth reduction of the piglets, and pathogenic bacteria can generate drug resistance by using a large amount of antibiotics, thereby further threatening the health of animals and human beings. Therefore, the stress of the piglets is obviously limited by using large-dose antibiotics, and the technology of the piglet anti-stress feed additive needs to be further researched and improved.
At present, antibiotics or drug additives are mostly directly used for treating the intestinal tract diseases of piglets in the healthy breeding process aiming at the intestinal tract diseases of the piglets, the treatment method has poor treatment effect and easy recurrence, the intestinal tract health of the piglets can not be improved by adopting the mode of combining traditional Chinese medicine preparations and probiotics to be taken by the piglets for a long time, the purpose of enabling the intestines and the stomach of the piglets to be more healthy by adopting the intestines and the stomach of the traditional Chinese medicine, promoting effect of the probiotics and the synergistic effect of other nutritional ingredients can not be achieved, the recurrence period of the intestinal tract diseases of the piglets can not be prolonged, and therefore great inconvenience is brought to the breeding of the piglets.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides the microcapsule which is used for improving the gastrointestinal tract health of piglets and takes nano zinc oxide as a carrier, and solves the problems that the existing treatment method has poor treatment effect and easy recurrence, the gastrointestinal health of the piglets cannot be improved by adopting the mode of combining a traditional Chinese medicine preparation and probiotics to be taken by the piglets for a long time, the gastrointestinal health of the piglets cannot be improved by adopting the synergistic effect of the traditional Chinese medicine preparation and the probiotics and other nutritional ingredients, the intestines and the stomach of the piglets are healthier, and the recurrence period of the intestinal tract disease of the piglets cannot be prolonged.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: the microcapsule which is used for improving the gastrointestinal tract health of piglets and takes nano zinc oxide as a carrier is characterized in that the outer wall material of the microcapsule is nano zinc oxide, and the raw materials of a medicament wrapped in the microcapsule comprise the following components in parts by weight: 30-40 parts of sweet potato, 5-6 parts of lysine, 5-10 parts of a probiotic preparation, 5-10 parts of sodium butyrate, 3-5 parts of glutamine dipeptide, 10-20 parts of a traditional Chinese medicine compound, 5-10 parts of apple pomace, 3-5 parts of glucose, 3-5 parts of yeast selenium, 1-3 parts of vitamin, 1-3 parts of citric acid, 1-3 parts of N-carbamylglutamic acid chelated copper and 1-3 parts of N-carbamylglutamic acid chelated zinc.
Preferably, the medicament wrapped in the microcapsule comprises the following raw materials in parts by weight: 35 parts of sweet potato, 5.5 parts of lysine, 7 parts of probiotic preparation, 7 parts of sodium butyrate, 4 parts of glutamine dipeptide, 15 parts of traditional Chinese medicine compound, 7 parts of apple pomace, 4 parts of glucose, 4 parts of yeast selenium, 2 parts of vitamin, 2 parts of citric acid, 2 parts of N-carbamylglutamic acid chelated copper and 2 parts of N-carbamylglutamic acid chelated zinc.
Preferably, the medicament wrapped in the microcapsule comprises the following raw materials in parts by weight: 30 parts of sweet potato, 5 parts of lysine, 5 parts of probiotic preparation, 5 parts of sodium butyrate, 3 parts of glutamine dipeptide, 10 parts of traditional Chinese medicine compound, 5 parts of apple pomace, 3 parts of glucose, 3 parts of yeast selenium, 1 part of vitamin, 1 part of citric acid, 1 part of N-carbamylglutamic acid chelated copper and 1 part of N-carbamylglutamic acid chelated zinc.
Preferably, the medicament wrapped in the microcapsule comprises the following raw materials in parts by weight: 40 parts of sweet potato, 6 parts of lysine, 10 parts of probiotic preparation, 10 parts of sodium butyrate, 5 parts of glutamine dipeptide, 20 parts of traditional Chinese medicine compound, 10 parts of apple pomace, 5 parts of glucose, 5 parts of yeast selenium, 3 parts of vitamin, 3 parts of citric acid, 3 parts of N-carbamylglutamic acid chelated copper and 3 parts of N-carbamylglutamic acid chelated zinc.
Preferably, the vitamin is one or a combination of more than two of vitamin A, vitamin E or vitamin C.
Preferably, the traditional Chinese medicine compound is any combination of two or more than two of green tangerine peel, rhizoma polygonati, immature bitter orange, astragalus, dried orange peel, white paeony root, mangnolia officinalis, fructus psoraleae, bighead atractylodes rhizome, purslane, poria cocos, andrographis paniculata, fructus amomi or honeysuckle.
Preferably, the probiotic preparation is a combined preparation of one or more of lactobacillus paracasei, enterococcus faecium and bacillus subtilis.
The invention also provides a method for improving the gastrointestinal tract health of piglets by using the nano zinc oxide as the carrier microcapsules, which specifically comprises the following steps:
s1, preparing materials: firstly, respectively weighing sweet potatoes, lysine, probiotic preparations, sodium butyrate, glutamine dipeptide, traditional Chinese medicine compounds, apple pomace, glucose, yeast selenium, vitamins, citric acid, N-carbamylglutamic acid chelated copper and N-carbamylglutamic acid chelated zinc in required weight parts by using a batching device, and respectively storing the weighed sweet potatoes, lysine, probiotic preparations, sodium butyrate, glutamine dipeptide, traditional Chinese medicine compounds, apple pomace, glucose, yeast selenium, vitamins, citric acid, N-carbamylglutamic acid chelated copper and N-carbamylglutamic acid chelated zinc by using a storage device for later use;
s2, grinding: respectively crushing and grinding the sweet potatoes, the traditional Chinese medicine compound and the apple pomace weighed in the step S1 in crushing and grinding equipment, sieving the crushed materials by a 100-200-mesh sieve after grinding, and collecting the sieved materials;
s3, mixing materials: pouring the sweet potatoes, the traditional Chinese medicine compound and the apple pomace ground in the step S2 into a mixing device, respectively pouring the lysine, the probiotic preparation, the sodium butyrate, the glutamine dipeptide, the glucose, the yeast selenium, the vitamin, the citric acid, the N-carbamylglutamic acid chelated copper and the N-carbamylglutamic acid chelated zinc weighed in the step S1 into the mixing device, and mixing and stirring for 1-2 hours at the rotating speed of 400-500r/min and the temperature of 30-40 ℃ to obtain a medicament;
s4, preparing a capsule: dripping the zinc acetate aqueous solution into the oil-in-water type emulsion, stirring for reaction, dripping the sodium hydroxide aqueous solution, continuing stirring for reaction, centrifugally washing the obtained product to obtain a microcapsule outer wall material taking nano zinc oxide as a wall material, and pouring the microcapsule outer wall material into forming equipment to obtain a zinc oxide microcapsule capsule body;
s5, filling: and (4) filling the medicament prepared in the step (S3) into the zinc oxide microcapsule obtained in the step (S4) through filling equipment, and folding to obtain the zinc oxide microcapsule.
(III) advantageous effects
The invention provides a microcapsule taking nano zinc oxide as a carrier for improving the gastrointestinal tract health of piglets. Compared with the prior art, the method has the following beneficial effects: the microcapsule for improving the gastrointestinal tract health of the piglets by taking the nano-zinc oxide as the carrier comprises the following raw materials in parts by weight: 30-40 parts of sweet potatoes, 5-6 parts of lysine, 5-10 parts of a probiotic preparation, 5-10 parts of sodium butyrate, 3-5 parts of glutamine dipeptide, 10-20 parts of a traditional Chinese medicine compound, 5-10 parts of apple pomace, 3-5 parts of glucose, 3-5 parts of yeast selenium, 1-3 parts of vitamins, 1-3 parts of citric acid, 1-3 parts of N-carbamylglutamic acid chelated copper and 1-3 parts of N-carbamylglutamic acid chelated zinc.
Drawings
FIG. 1 is a flow chart of the preparation method of the nano zinc oxide microcapsule of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
Referring to fig. 1, the embodiment of the present invention provides three technical solutions: the microcapsule taking the nano zinc oxide as the carrier for improving the gastrointestinal tract health of the piglets specifically comprises the following embodiments:
example 1
The microcapsule which is used for improving the gastrointestinal tract health of piglets and takes nano zinc oxide as a carrier comprises the following raw materials in parts by weight: 35 parts of sweet potato, 5.5 parts of lysine, 7 parts of probiotic preparation, 7 parts of sodium butyrate, 4 parts of glutamine dipeptide, 15 parts of traditional Chinese medicine compound, 7 parts of apple pomace, 4 parts of glucose, 4 parts of yeast selenium, 2 parts of vitamin, 2 parts of citric acid, 2 parts of N-carbamylglutamic acid chelated copper and 2 parts of N-carbamylglutamic acid chelated zinc.
The vitamins are the composition of vitamin A, vitamin E and vitamin C, the traditional Chinese medicine compound is the composition of green tangerine orange peel, rhizoma polygonati, immature bitter orange, astragalus, dried orange peel, white paeony root, officinal magnolia bark, malaytea scurfpea fruit, largehead atractylodes rhizome, purslane, tuckahoe, common andrographis herb, villous amomum fruit and honeysuckle, and the probiotic preparation is the combined preparation of lactobacillus paracasei, enterococcus faecium and bacillus subtilis.
The preparation method of the microcapsule taking the nano zinc oxide as the carrier for improving the gastrointestinal tract health of the piglets comprises the following steps:
s1, preparing materials: firstly, respectively weighing sweet potatoes, lysine, probiotic preparations, sodium butyrate, glutamine dipeptide, traditional Chinese medicine compounds, apple pomace, glucose, yeast selenium, vitamins, citric acid, N-carbamyl glutamic acid chelated copper and N-carbamyl glutamic acid chelated zinc in required weight parts by using a batching device, and respectively storing the weighed sweet potatoes, lysine, probiotic preparations, sodium butyrate, glutamine dipeptide, traditional Chinese medicine compounds, apple pomace, glucose, yeast selenium, vitamins, citric acid, N-carbamyl glutamic acid chelated copper and N-carbamyl glutamic acid chelated zinc by using a storage device for later use;
s2, grinding: respectively crushing and grinding the sweet potatoes, the traditional Chinese medicine compound and the apple pomace weighed in the step S1 in crushing and grinding equipment, sieving the crushed materials with a 150-mesh sieve after grinding, and collecting the sieved materials;
s3, mixing materials: pouring the sweet potatoes, the traditional Chinese medicine compound and the apple pomace ground in the step S2 into a mixing device, respectively pouring the lysine, the probiotic preparation, the sodium butyrate, the glutamine dipeptide, the glucose, the yeast selenium, the vitamin, the citric acid, the N-carbamylglutamic acid chelated copper and the N-carbamylglutamic acid chelated zinc weighed in the step S1 into the mixing device, and mixing and stirring for 1.5 hours at the rotating speed of 450r/min and the temperature of 35 ℃ to obtain a medicament;
s4, preparing a capsule: dripping the zinc acetate aqueous solution into the oil-in-water type emulsion, stirring for reaction, dripping the sodium hydroxide aqueous solution, continuing stirring for reaction, centrifugally washing the obtained product to obtain a microcapsule outer wall material taking nano zinc oxide as a wall material, and pouring the microcapsule outer wall material into forming equipment to obtain a zinc oxide microcapsule capsule body;
s5, filling: and (4) filling the medicament prepared in the step (S3) into the zinc oxide microcapsule obtained in the step (S4) through filling equipment, and folding to obtain the zinc oxide microcapsule.
Example 2
The microcapsule which is used for improving the gastrointestinal tract health of piglets and takes nano zinc oxide as a carrier comprises the following raw materials in parts by weight: 30 parts of sweet potato, 5 parts of lysine, 5 parts of probiotic preparation, 5 parts of sodium butyrate, 3 parts of glutamine dipeptide, 10 parts of traditional Chinese medicine compound, 5 parts of apple pomace, 3 parts of glucose, 3 parts of yeast selenium, 1 part of vitamin, 1 part of citric acid, 1 part of N-carbamylglutamic acid chelated copper and 1 part of N-carbamylglutamic acid chelated zinc.
The vitamin is vitamin A, the Chinese medicinal composition is a composition of pericarpium Citri Reticulatae viride, rhizoma Polygonati, fructus Aurantii Immaturus, radix astragali, pericarpium Citri Tangerinae, radix Paeoniae alba and cortex Magnolia officinalis, and the probiotic preparation is Lactobacillus paracasei.
The preparation method of the microcapsule taking the nano zinc oxide as the carrier for improving the gastrointestinal tract health of the piglets comprises the following steps:
s1, preparing materials: firstly, respectively weighing sweet potatoes, lysine, probiotic preparations, sodium butyrate, glutamine dipeptide, traditional Chinese medicine compounds, apple pomace, glucose, yeast selenium, vitamins, citric acid, N-carbamyl glutamic acid chelated copper and N-carbamyl glutamic acid chelated zinc in required weight parts by using a batching device, and respectively storing the weighed sweet potatoes, lysine, probiotic preparations, sodium butyrate, glutamine dipeptide, traditional Chinese medicine compounds, apple pomace, glucose, yeast selenium, vitamins, citric acid, N-carbamyl glutamic acid chelated copper and N-carbamyl glutamic acid chelated zinc by using a storage device for later use;
s2, grinding: respectively crushing and grinding the sweet potatoes, the traditional Chinese medicine compound and the apple pomace weighed in the step S1 in crushing and grinding equipment, sieving the crushed materials with a 100-mesh sieve after grinding, and collecting the sieved materials;
s3, mixing materials: pouring the sweet potatoes, the traditional Chinese medicine compound and the apple pomace ground in the step S2 into a mixing device, respectively pouring the lysine, the probiotic preparation, the sodium butyrate, the glutamine dipeptide, the glucose, the yeast selenium, the vitamin, the citric acid, the N-carbamylglutamic acid chelated copper and the N-carbamylglutamic acid chelated zinc weighed in the step S1 into the mixing device, and mixing and stirring for 1h at the rotating speed of 400r/min and the temperature of 30 ℃ to obtain a medicament;
s4, preparing a capsule: dripping the zinc acetate aqueous solution into the oil-in-water type emulsion, stirring for reaction, dripping the sodium hydroxide aqueous solution, continuing stirring for reaction, centrifugally washing the obtained product to obtain a microcapsule outer wall material taking nano zinc oxide as a wall material, and pouring the microcapsule outer wall material into forming equipment to obtain a zinc oxide microcapsule capsule body;
s5, filling: and (4) filling the medicament prepared in the step (S3) into the zinc oxide microcapsule obtained in the step (S4) through filling equipment, and folding to obtain the zinc oxide microcapsule.
Example 3
The microcapsule which is used for improving the gastrointestinal tract health of piglets and takes nano zinc oxide as a carrier comprises the following raw materials in parts by weight: 40 parts of sweet potatoes, 6 parts of lysine, 10 parts of probiotic preparation, 10 parts of sodium butyrate, 5 parts of glutamine dipeptide, 20 parts of traditional Chinese medicine compound, 10 parts of apple pomace, 5 parts of glucose, 5 parts of yeast selenium, 3 parts of vitamin, 3 parts of citric acid, 3 parts of N-carbamylglutamic acid chelated copper and 3 parts of N-carbamylglutamic acid chelated zinc.
The vitamin is vitamin C, the Chinese medicinal composition is a composition of fructus Psoraleae, atractylodis rhizoma, herba Portulacae, poria, herba Andrographitis, fructus Amomi and flos Lonicerae, and the probiotic preparation is Bacillus subtilis.
The preparation method of the microcapsule taking the nano zinc oxide as the carrier for improving the gastrointestinal tract health of the piglets comprises the following steps:
s1, preparing materials: firstly, respectively weighing sweet potatoes, lysine, probiotic preparations, sodium butyrate, glutamine dipeptide, traditional Chinese medicine compounds, apple pomace, glucose, yeast selenium, vitamins, citric acid, N-carbamylglutamic acid chelated copper and N-carbamylglutamic acid chelated zinc in required weight parts by using a batching device, and respectively storing the weighed sweet potatoes, lysine, probiotic preparations, sodium butyrate, glutamine dipeptide, traditional Chinese medicine compounds, apple pomace, glucose, yeast selenium, vitamins, citric acid, N-carbamylglutamic acid chelated copper and N-carbamylglutamic acid chelated zinc by using a storage device for later use;
s2, grinding: respectively crushing and grinding the sweet potatoes, the traditional Chinese medicine compound and the apple pomace weighed in the step S1 in crushing and grinding equipment, sieving the crushed materials with a 200-mesh sieve after grinding, and collecting the sieved materials;
s3, mixing materials: pouring the sweet potatoes, the traditional Chinese medicine compound and the apple pomace ground in the step S2 into a mixing device, respectively pouring the lysine, the probiotic preparation, the sodium butyrate, the glutamine dipeptide, the glucose, the yeast selenium, the vitamin, the citric acid, the N-carbamylglutamic acid chelated copper and the N-carbamylglutamic acid chelated zinc weighed in the step S1 into the mixing device, and mixing and stirring for 2 hours at the rotating speed of 500r/min and the temperature of 40 ℃ to obtain a medicament;
s4, preparing capsules: dripping a zinc acetate aqueous solution into the oil-in-water type emulsion, stirring for reaction, dripping a sodium hydroxide aqueous solution, continuously stirring for reaction, centrifugally washing an obtained product to obtain a microcapsule outer wall material taking nano zinc oxide as a wall material, and pouring the microcapsule outer wall material into forming equipment to obtain a zinc oxide microcapsule capsule body;
s5, filling: and (4) filling the medicament prepared in the step (S3) into the zinc oxide microcapsule obtained in the step (S4) through filling equipment, and folding to obtain the zinc oxide microcapsule.
In conclusion, the invention can improve the intestine and stomach health of the piglets by adopting the mode of combining the traditional Chinese medicine preparation and the probiotics for long-term administration of the piglets, well achieves the aim of ensuring the intestine and stomach of the piglets to be healthier by adopting the synergistic effect of the traditional Chinese medicine, promoting effect of the probiotics and other nutritional ingredients, greatly improves the treatment effect, realizes the purpose of prolonging the relapse period of the intestinal tract diseases of the piglets, and greatly facilitates the breeding of the piglets.
And those not described in detail in this specification are well within the skill of those in the art.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. The microcapsule taking the nano zinc oxide as the carrier for improving the gastrointestinal tract health of the piglets is characterized in that: the outer wall material of the microcapsule is nano zinc oxide, and the medicament wrapped in the microcapsule comprises the following raw materials in parts by weight: 30-40 parts of sweet potato, 5-6 parts of lysine, 5-10 parts of a probiotic preparation, 5-10 parts of sodium butyrate, 3-5 parts of glutamine dipeptide, 10-20 parts of a traditional Chinese medicine compound, 5-10 parts of apple pomace, 3-5 parts of glucose, 3-5 parts of yeast selenium, 1-3 parts of vitamin, 1-3 parts of citric acid, 1-3 parts of N-carbamylglutamic acid chelated copper and 1-3 parts of N-carbamylglutamic acid chelated zinc.
2. The microcapsule with nano zinc oxide as a carrier for improving the gastrointestinal health of piglets according to claim 1, wherein: the medicament wrapped in the microcapsule comprises the following raw materials in parts by weight: 35 parts of sweet potatoes, 5.5 parts of lysine, 7 parts of probiotic preparation, 7 parts of sodium butyrate, 4 parts of glutamine dipeptide, 15 parts of traditional Chinese medicine compound, 7 parts of apple pomace, 4 parts of glucose, 4 parts of yeast selenium, 2 parts of vitamin, 2 parts of citric acid, 2 parts of N-carbamyl glutamic acid chelated copper and 2 parts of N-carbamyl glutamic acid chelated zinc.
3. The microcapsule with nano zinc oxide as a carrier for improving the gastrointestinal health of piglets according to claim 1, wherein: the medicament wrapped in the microcapsule comprises the following raw materials in parts by weight: 30 parts of sweet potato, 5 parts of lysine, 5 parts of probiotic preparation, 5 parts of sodium butyrate, 3 parts of glutamine dipeptide, 10 parts of traditional Chinese medicine compound, 5 parts of apple pomace, 3 parts of glucose, 3 parts of yeast selenium, 1 part of vitamin, 1 part of citric acid, 1 part of N-carbamylglutamic acid chelated copper and 1 part of N-carbamylglutamic acid chelated zinc.
4. The microcapsule with nano zinc oxide as a carrier for improving the gastrointestinal health of piglets according to claim 1, wherein: the medicament wrapped in the microcapsule comprises the following raw materials in parts by weight: 40 parts of sweet potato, 6 parts of lysine, 10 parts of probiotic preparation, 10 parts of sodium butyrate, 5 parts of glutamine dipeptide, 20 parts of traditional Chinese medicine compound, 10 parts of apple pomace, 5 parts of glucose, 5 parts of yeast selenium, 3 parts of vitamin, 3 parts of citric acid, 3 parts of N-carbamylglutamic acid chelated copper and 3 parts of N-carbamylglutamic acid chelated zinc.
5. The microcapsule with nano zinc oxide as a carrier for improving the gastrointestinal tract health of piglets according to any one of claims 1 to 4, wherein the microcapsule comprises the following components in percentage by weight: the vitamin is one or more of vitamin A, vitamin E or vitamin C.
6. The microcapsule with nano zinc oxide as a carrier for improving the gastrointestinal tract health of piglets according to any one of claims 1 to 4, wherein the microcapsule comprises the following components in percentage by weight: the Chinese medicinal composition is any combination of two or more of pericarpium Citri Reticulatae viride, rhizoma Polygonati, fructus Aurantii Immaturus, radix astragali, pericarpium Citri Tangerinae, radix Paeoniae alba, cortex Magnolia officinalis, fructus Psoraleae, atractylodis rhizoma, herba Portulacae, poria, herba Andrographitis, fructus Amomi or flos Lonicerae.
7. The microcapsule with nano zinc oxide as a carrier for improving the gastrointestinal tract health of piglets according to any one of claims 1 to 4, wherein the microcapsule comprises the following components in percentage by weight: the probiotic preparation is one or more of lactobacillus paracasei, enterococcus faecium and bacillus subtilis.
8. The method for preparing the microcapsule which is used for improving the gastrointestinal tract health of the piglets and takes the nano zinc oxide as the carrier according to any one of the claims 1 to 4, is characterized in that: the method specifically comprises the following steps:
s1, preparing materials: firstly, respectively weighing sweet potatoes, lysine, probiotic preparations, sodium butyrate, glutamine dipeptide, traditional Chinese medicine compounds, apple pomace, glucose, yeast selenium, vitamins, citric acid, N-carbamylglutamic acid chelated copper and N-carbamylglutamic acid chelated zinc in required weight parts by using a batching device, and respectively storing the weighed sweet potatoes, lysine, probiotic preparations, sodium butyrate, glutamine dipeptide, traditional Chinese medicine compounds, apple pomace, glucose, yeast selenium, vitamins, citric acid, N-carbamylglutamic acid chelated copper and N-carbamylglutamic acid chelated zinc by using a storage device for later use;
s2, grinding: respectively crushing and grinding the sweet potatoes, the traditional Chinese medicine compound and the apple pomace weighed in the step S1 in crushing and grinding equipment, sieving the crushed materials by a 100-200-mesh sieve after grinding, and collecting the sieved materials;
s3, mixing materials: pouring the sweet potatoes, the traditional Chinese medicine compound and the apple pomace ground in the step S2 into a mixing device, respectively pouring the lysine, the probiotic preparation, the sodium butyrate, the glutamine dipeptide, the glucose, the yeast selenium, the vitamin, the citric acid, the N-carbamylglutamic acid chelated copper and the N-carbamylglutamic acid chelated zinc weighed in the step S1 into the mixing device, and mixing and stirring for 1-2 hours at the rotating speed of 400-500r/min and the temperature of 30-40 ℃ to obtain a medicament;
s4, preparing a capsule: dripping the zinc acetate aqueous solution into the oil-in-water type emulsion, stirring for reaction, dripping the sodium hydroxide aqueous solution, continuing stirring for reaction, centrifugally washing the obtained product to obtain a microcapsule outer wall material taking nano zinc oxide as a wall material, and pouring the microcapsule outer wall material into forming equipment to obtain a zinc oxide microcapsule capsule body;
s5, filling: and (4) filling the medicament prepared in the step (S3) into the zinc oxide microcapsule obtained in the step (S4) through filling equipment, and folding to obtain the zinc oxide microcapsule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116159037A (en) * | 2023-04-25 | 2023-05-26 | 四川省川龙动科药业有限公司 | Targeted pellet composition for preventing and treating piglet colitis and preparation method thereof |
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| CN102198115A (en) * | 2011-05-19 | 2011-09-28 | 甘肃易源生物制药有限公司 | Enteric-coated micro-capsule prepared by mixing traditional Chinese medicine extract and probitics |
| CN104435283A (en) * | 2014-11-17 | 2015-03-25 | 金陵科技学院 | Probiotic microcapsule added with prebiotics and preparation method thereof |
| CN104938866A (en) * | 2015-07-14 | 2015-09-30 | 漳州傲农牧业科技有限公司 | Feed additive with piglet stress resistance and intestinal tract improvement effects and preparation method and application |
| CN106266101A (en) * | 2016-08-16 | 2017-01-04 | 四川恒通动物制药有限公司 | A kind of veterinary Chinese medicinal composition and its production and use |
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| CN102198115A (en) * | 2011-05-19 | 2011-09-28 | 甘肃易源生物制药有限公司 | Enteric-coated micro-capsule prepared by mixing traditional Chinese medicine extract and probitics |
| CN104435283A (en) * | 2014-11-17 | 2015-03-25 | 金陵科技学院 | Probiotic microcapsule added with prebiotics and preparation method thereof |
| CN104938866A (en) * | 2015-07-14 | 2015-09-30 | 漳州傲农牧业科技有限公司 | Feed additive with piglet stress resistance and intestinal tract improvement effects and preparation method and application |
| CN106266101A (en) * | 2016-08-16 | 2017-01-04 | 四川恒通动物制药有限公司 | A kind of veterinary Chinese medicinal composition and its production and use |
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