CN115671039A - Cream and production process thereof - Google Patents
Cream and production process thereof Download PDFInfo
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- CN115671039A CN115671039A CN202211644867.1A CN202211644867A CN115671039A CN 115671039 A CN115671039 A CN 115671039A CN 202211644867 A CN202211644867 A CN 202211644867A CN 115671039 A CN115671039 A CN 115671039A
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Abstract
The invention discloses a cream and a production process thereof, and the cream comprises a 022 raw material drug, butyl hydroxy anisole, liquid paraffin, cetyl alcohol, glycerol, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water, wherein the portion of the 022 raw material drug is 2.0%, the portion of the butyl hydroxy anisole is 0.004%, the portion of the liquid paraffin is 11.1%, the portion of the cetyl alcohol is 11.1%, the portion of the glycerol is 11.1%, the portion of the potassium sorbate is 0.27%, the portion of the polysorbate 60 is 5.6%, the portion of the white vaseline is 5.6%, an active ingredient is arranged inside the 022 raw material drug, an antioxidant ingredient is arranged inside the butyl hydroxy anisole, and a thickening ingredient is arranged inside the liquid paraffin. According to the cream and the production process thereof, the quality consistency problem of the 022 cream and the reference medicine is solved by placing or stirring the intermediate product of the preparation and detecting every few days until the quality of the preparation is stable.
Description
Technical Field
The invention relates to the field of cream preparation, and in particular relates to a cream and a production process thereof.
Background
The cream preparation process is a cream production and processing method, and refers to a semisolid external preparation with certain consistency prepared by uniformly mixing a medicament and a proper matrix, wherein an active component is arranged in the cream, and a certain amount of auxiliary reagent is added to be coated on skin or mucous membrane to play roles of protecting wound surfaces, lubricating skin and locally treating.
In the prior art, a patent with an authorization publication number of CN1771969 discloses an external cream for treating dermatitis and eczema, which is prepared from 1 part of medicinal active ingredients of clobetasol propionate and 30 to 50 parts of borneol by a conventional preparation method, and also comprises octadecanol, stearic acid, glyceryl monostearate, liquid paraffin, glycerol, an HR-S1 type emulsifier, emulsified silicone oil and an ethylparaben excipient according to the conventional proportion of the cream, wherein the dosage is selected according to the dosage of the conventional excipient in the cream.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides the cream and the production process thereof, and the quality consistency problem of the 022 cream and the contrast medicine is solved by placing or stirring the intermediate product of the preparation every few days until the preparation quality is stable, so that the problems in the background art can be effectively solved.
(II) technical scheme
In order to achieve the purpose, the invention adopts the technical scheme that: a cream comprises a 022 raw material drug, butyl hydroxy anisole, liquid paraffin, cetyl alcohol, glycerin, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water, wherein the share of the 022 raw material drug is 2.0%, the share of the butyl hydroxy anisole is 0.004%, the share of the liquid paraffin is 11.1%, the share of the cetyl alcohol is 11.1%, the share of the glycerin is 11.1%, the share of the potassium sorbate is 0.27%, the share of the polysorbate 60 is 5.6%, and the share of the white vaseline is 5.6%.
As a preferred technical scheme of this application, 022 bulk drug is inside to be active ingredient, the inside anti-oxidant composition that is of butyl hydroxyanisole, the inside thickening composition that is of liquid paraffin, the inside thickening composition that is of hexadecanol, the inside moisturizing composition that is of glycerine, the inside anticorrosive composition that is of potassium sorbate, the inside emulsification composition that is of polysorbate 60, the inside thickening composition that is of white vaseline, the inside solvent composition that is of purified water.
As a preferred technical solution, the 022 raw material drug, butyl hydroxy anisole, liquid paraffin, cetyl alcohol, glycerin, potassium sorbate, polysorbate 60, white vaseline, and a proper amount of purified water are mixed to form a first cream sample, and the first cream sample is placed at room temperature for 30 days and the viscosity of the cream sample is analyzed.
As a preferred technical scheme, the 022 raw material drug, butyl hydroxyanisole, liquid paraffin, cetyl alcohol, glycerin, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water are mixed to form a second cream sample, the second cream sample is placed at room temperature for 1 day, then stirred and placed continuously, and the viscosity of the cream sample is analyzed.
As a preferable technical scheme, the 022 bulk drug, the butyl hydroxyanisole, the liquid paraffin, the hexadecanol, the glycerol, the potassium sorbate, the polysorbate 60, the white vaseline and a proper amount of purified water are mixed to form a third cream sample, the third cream sample is placed at room temperature for 3 days, stirred and then continuously placed, and the viscosity of the cream sample is analyzed.
As a preferred technical scheme, the 022 raw material drug, butyl hydroxy anisole, liquid paraffin, cetyl alcohol, glycerol, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water are mixed to form a fourth cream sample, the fourth cream sample is placed at room temperature for 5 days, then stirred and placed continuously, and the viscosity of the cream sample is analyzed.
As a preferred technical scheme, the 022 raw material drug, butyl hydroxyanisole, liquid paraffin, cetyl alcohol, glycerin, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water are mixed to form a fifth cream sample, the fifth cream sample is placed at room temperature for 7 days, stirred and then continuously placed, and the viscosity of the cream sample is analyzed.
A production process of cream comprises the following operation steps:
s1: preparing materials: preparing raw materials required for preparing cream, including 022 raw material medicine, butyl hydroxy anisole, liquid paraffin, cetyl alcohol, glycerol, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water;
s2: the first technical scheme is as follows: mixing the prepared raw materials, standing at room temperature for 30 days and analyzing the viscosity of a cream sample;
s3: the second process scheme comprises the following steps: mixing the prepared raw materials, standing at room temperature for 1 day, stirring, standing continuously, and analyzing the viscosity of the cream sample;
s4: the third technical proposal is as follows: mixing the prepared raw materials, standing at room temperature for 3 days, stirring, standing continuously, and analyzing the viscosity of the cream sample;
s5: the fourth technical proposal is as follows: mixing the prepared raw materials, standing at room temperature for 4 days, stirring, standing continuously, and analyzing the viscosity of the cream sample;
s6: the fifth technical proposal is as follows: mixing the prepared raw materials, standing at room temperature for 5 days, stirring, standing continuously, and analyzing the viscosity of the cream sample;
s7: summary analysis: the sample is placed for 30 days all the time, and the viscosity of the sample is similar to that of the contrast medicine; the sample is stirred after being placed for 1 day and then is placed for 3 days, and the viscosity of the sample is similar to that of the contrast medicine; the sample is stirred after being placed for 3 days and then is placed for 1 day, and the viscosity of the sample is similar to that of the contrast medicine; the sample is stirred after being placed for 5 days and is not placed any more, and the viscosity of the sample is similar to that of the contrast medicine; the sample is not placed after being stirred for 7 days, and the viscosity of the sample is lower than that of the reference drug, so that the sample is placed for 5 days and is not stirred.
(III) advantageous effects
Compared with the prior art, the invention provides the cream and the production process thereof, and the cream has the following beneficial effects: the cream and the production process thereof are characterized in that the quality consistency problem of the 022 cream and a reference medicine is solved by placing or stirring the intermediate product of the preparation and detecting every few days until the preparation has stable quality, and raw materials required for preparing the cream comprise 022 raw material medicine, butyl hydroxy anisole, liquid paraffin, cetyl alcohol, glycerin, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water; the first technical scheme is as follows: mixing the prepared raw materials, standing at room temperature for 30 days and analyzing the viscosity of a cream sample; the second process scheme comprises the following steps: mixing the prepared raw materials, standing at room temperature for 1 day, stirring, standing continuously, and analyzing the viscosity of the cream sample; the third technical proposal is as follows: mixing the prepared raw materials, standing at room temperature for 3 days, stirring, standing continuously, and analyzing the viscosity of the cream sample; the fourth technical proposal is as follows: mixing the prepared raw materials, standing at room temperature for 4 days, stirring, standing continuously, and analyzing the viscosity of the cream sample; the fifth technical proposal: mixing the prepared raw materials, standing at room temperature for 5 days, stirring, standing continuously, and analyzing the viscosity of the cream sample;
summary analysis: the sample is placed for 30 days all the time, and the viscosity of the sample is similar to that of the contrast medicine; the sample is stirred after being placed for 1 day and then is placed for 3 days, and the viscosity of the sample is similar to that of the contrast medicine; the sample is stirred after being placed for 3 days and then is placed for 1 day, and the viscosity of the sample is similar to that of the contrast medicine; the sample is stirred after being placed for 5 days and is not placed any more, and the viscosity of the sample is similar to that of the contrast medicine; the sample is not placed after being placed for 7 days, the viscosity of the sample is lower than that of a contrast medicine, so that the sample is placed for 5 days, the stirring is not performed, the whole cream preparation process is simple, the operation is convenient, and the using effect is better than that of the traditional mode.
Drawings
Fig. 1 is an overall schematic view of a cream and a production process thereof according to the present invention.
Fig. 2 is a schematic diagram of a standing time investigation scheme in the cream and the production process thereof.
FIG. 3 is a schematic illustration of a comparison of viscosity results for a cream and process of making the same according to the present invention.
Detailed Description
The technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings and the detailed description, but those skilled in the art will understand that the following described embodiments are a part of the embodiments of the present invention, rather than all of the embodiments, and are only used for illustrating the present invention, and should not be construed as limiting the scope of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
As shown in fig. 1-3, a cream comprises 022 raw material drug, butyl hydroxy anisole, liquid paraffin, cetyl alcohol, glycerin, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water, wherein the portion of the 022 raw material drug is 2.0%, the portion of the butyl hydroxy anisole is 0.004%, the portion of the liquid paraffin is 11.1%, the portion of the cetyl alcohol is 11.1%, the portion of the glycerin is 11.1%, the portion of the potassium sorbate is 0.27%, the portion of the polysorbate 60 is 5.6%, and the portion of the white vaseline is 5.6%.
Furthermore, 022 the bulk drug contains active ingredients inside, butyl hydroxyanisole contains antioxidant ingredients inside, liquid paraffin contains thickening ingredients inside, hexadecanol contains thickening ingredients inside, glycerin contains moisturizing ingredients inside, potassium sorbate contains antiseptic ingredients inside, polysorbate 60 contains emulsifying ingredients inside, white vaseline contains thickening ingredients inside, and purified water contains solvent ingredients inside.
Example 1:
022 mixing raw material medicines, butyl hydroxy anisole, liquid paraffin, hexadecanol, glycerol, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water to form a first cream sample, standing at room temperature for 30 days, and analyzing the viscosity of the cream sample;
the sample is kept for 30 days, and the viscosity of the sample is similar to that of the control drug.
Example 2:
022 mixing the raw materials, butyl hydroxy anisole, liquid paraffin, cetyl alcohol, glycerol, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water to form a second cream sample, standing at room temperature for 1 day, stirring, standing again, and analyzing the viscosity of the cream sample;
the sample is stirred after being placed for 1 day and then is placed for 3 days, and the viscosity of the sample is similar to that of the control drug.
Example 3:
022 mixing the raw materials, butyl hydroxy anisole, liquid paraffin, cetyl alcohol, glycerol, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water to form a third cream sample, standing at room temperature for 3 days, stirring, standing again, and analyzing the viscosity of the cream sample;
the sample is stirred after being placed for 3 days and then is placed for 1 day, and the viscosity of the sample is similar to that of the contrast medicine.
Example 4:
022 mixing the bulk drugs, butyl hydroxyanisole, liquid paraffin, hexadecanol, glycerol, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water to form a fourth cream sample, standing at room temperature for 5 days, stirring, continuing to stand, and analyzing the viscosity of the cream sample;
the sample is left for 5 days without stirring, and the viscosity of the sample is similar to that of the control drug.
Example 5:
022 mixing the bulk drug, butyl hydroxy anisole, liquid paraffin, cetyl alcohol, glycerol, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water to form a fifth cream sample, standing at room temperature for 7 days, stirring, standing again, and analyzing the viscosity of the cream sample;
the samples were left for 7 days without further stirring and the viscosity of the samples was lower than that of the control drug.
Therefore, the sample is stirred for 5 days without standing.
A production process of cream comprises the following operation steps:
s1: preparing materials: preparing raw materials required for preparing cream, including 022 raw material medicine, butyl hydroxy anisole, liquid paraffin, cetyl alcohol, glycerol, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water;
s2: the first technical scheme is as follows: mixing the prepared raw materials, standing at room temperature for 30 days and analyzing the viscosity of a cream sample;
s3: the second technical scheme is as follows: mixing the prepared raw materials, standing at room temperature for 1 day, stirring, standing continuously, and analyzing the viscosity of the cream sample;
s4: the third technical proposal is as follows: mixing the prepared raw materials, standing at room temperature for 3 days, stirring, standing continuously, and analyzing the viscosity of the cream sample;
s5: the fourth process scheme is as follows: mixing the prepared raw materials, standing at room temperature for 4 days, stirring, standing continuously, and analyzing the viscosity of the cream sample;
s6: the fifth technical proposal: mixing the prepared raw materials, standing at room temperature for 5 days, stirring, standing continuously, and analyzing the viscosity of the cream sample;
s7: summary analysis: the sample is placed for 30 days all the time, and the viscosity of the sample is similar to that of the contrast medicine; the sample is stirred after being placed for 1 day and then is placed for 3 days, and the viscosity of the sample is similar to that of the contrast medicine; the sample is stirred after being placed for 3 days and then is placed for 1 day, and the viscosity of the sample is similar to that of the contrast medicine; the sample is stirred after being placed for 5 days and is not placed any more, and the viscosity of the sample is similar to that of the contrast medicine; the sample is not placed after being stirred for 7 days, and the viscosity of the sample is lower than that of the reference drug, so that the sample is placed for 5 days and is not stirred.
It is noted that, herein, relational terms such as first and second (a, b, etc.) and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrases "comprising a," "8230," "8230," or "comprising" does not exclude the presence of additional like elements in a process, method, article, or apparatus that comprises the element.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed.
Claims (8)
1. A cream comprises 022 raw material medicines, butyl hydroxy anisole, liquid paraffin, cetyl alcohol, glycerol, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water, and is characterized in that: the weight percentage of the 022 raw material medicine is 2.0%, the weight percentage of the butyl hydroxyanisole is 0.004%, the weight percentage of the liquid paraffin is 11.1%, the weight percentage of the hexadecanol is 11.1%, the weight percentage of the glycerol is 11.1%, the weight percentage of the potassium sorbate is 0.27%, the weight percentage of the polysorbate 60 is 5.6%, and the weight percentage of the white vaseline is 5.6%.
2. A cream formulation according to claim 1, characterised in that: the 022 bulk drug is internally provided with an active ingredient, the butyl hydroxyanisole is internally provided with an antioxidant ingredient, the liquid paraffin is internally provided with a thickening ingredient, the hexadecanol is internally provided with a thickening ingredient, the glycerol is internally provided with a moisturizing ingredient, the potassium sorbate is internally provided with an antiseptic ingredient, the polysorbate 60 is internally provided with an emulsifying ingredient, the white vaseline is internally provided with a thickening ingredient, and the purified water is internally provided with a solvent ingredient.
3. A cream formulation according to claim 1, characterised in that: the 022 raw material medicine, butyl hydroxy anisole, liquid paraffin, cetyl alcohol, glycerol, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water are mixed to form a first cream sample, the first cream sample is placed at room temperature for 30 days, and the viscosity of the cream sample is analyzed.
4. A cream formulation according to claim 1, characterised in that: the 022 raw material medicine, the butyl hydroxy anisole, the liquid paraffin, the hexadecanol, the glycerol, the potassium sorbate, the polysorbate 60, the white vaseline and a proper amount of purified water are mixed to form a second cream sample, the second cream sample is placed at room temperature for 1 day, stirred and then continuously placed, and the viscosity of the cream sample is analyzed.
5. A cream according to claim 1, wherein: the 022 raw material medicine, the butyl hydroxy anisole, the liquid paraffin, the hexadecanol, the glycerol, the potassium sorbate, the polysorbate 60, the white vaseline and a proper amount of purified water are mixed to form a third cream sample, the third cream sample is placed at room temperature for 3 days, stirred and then continuously placed, and the viscosity of the cream sample is analyzed.
6. A cream according to claim 1, wherein: the 022 raw material medicine, the butyl hydroxy anisole, the liquid paraffin, the hexadecanol, the glycerol, the potassium sorbate, the polysorbate 60, the white vaseline and a proper amount of purified water are mixed to form a fourth cream sample, the fourth cream sample is placed at room temperature for 5 days, stirred and then continuously placed, and the viscosity of the cream sample is analyzed.
7. A cream according to claim 1, wherein: the 022 raw material medicine, the butyl hydroxy anisole, the liquid paraffin, the hexadecanol, the glycerol, the potassium sorbate, the polysorbate 60, the white vaseline and a proper amount of purified water are mixed to form a fifth cream sample, the fifth cream sample is placed at room temperature for 7 days, stirred and then continuously placed, and the viscosity of the cream sample is analyzed.
8. A production process of cream is characterized in that: the method comprises the following operation steps:
s1: preparing materials: preparing raw materials required for preparing cream, including 022 raw material medicine, butyl hydroxy anisole, liquid paraffin, cetyl alcohol, glycerol, potassium sorbate, polysorbate 60, white vaseline and a proper amount of purified water;
s2: the first technical scheme is as follows: mixing the prepared raw materials, standing at room temperature for 30 days and analyzing the viscosity of a cream sample;
s3: the second technical scheme is as follows: mixing the prepared raw materials, standing at room temperature for 1 day, stirring, standing continuously, and analyzing the viscosity of the cream sample;
s4: the third technical proposal is as follows: mixing the prepared raw materials, standing at room temperature for 3 days, stirring, standing continuously, and analyzing the viscosity of the cream sample;
s5: the fourth process scheme is as follows: mixing the prepared raw materials, standing at room temperature for 4 days, stirring, standing continuously, and analyzing the viscosity of the cream sample;
s6: the fifth technical proposal: mixing the prepared raw materials, standing at room temperature for 5 days, stirring, standing continuously, and analyzing the viscosity of the cream sample;
s7: summary analysis: the sample is placed for 30 days all the time, and the viscosity of the sample is similar to that of the contrast medicine; the sample is stirred after being placed for 1 day and then is placed for 3 days, and the viscosity of the sample is similar to that of the contrast medicine; the sample is stirred after being placed for 3 days and then is placed for 1 day, and the viscosity of the sample is similar to that of the contrast medicine; the sample is stirred after being placed for 5 days and is not placed any more, and the viscosity of the sample is similar to that of the contrast medicine; the sample is not placed after being stirred for 7 days, and the viscosity of the sample is lower than that of the reference drug, so that the sample is placed for 5 days and is not stirred.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211644867.1A CN115671039A (en) | 2022-12-21 | 2022-12-21 | Cream and production process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211644867.1A CN115671039A (en) | 2022-12-21 | 2022-12-21 | Cream and production process thereof |
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| Publication Number | Publication Date |
|---|---|
| CN115671039A true CN115671039A (en) | 2023-02-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211644867.1A Pending CN115671039A (en) | 2022-12-21 | 2022-12-21 | Cream and production process thereof |
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|---|---|
| CN (1) | CN115671039A (en) |
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- 2022-12-21 CN CN202211644867.1A patent/CN115671039A/en active Pending
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