CN115645308A - Cosmetic composition and application thereof - Google Patents
Cosmetic composition and application thereof Download PDFInfo
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- CN115645308A CN115645308A CN202211329361.1A CN202211329361A CN115645308A CN 115645308 A CN115645308 A CN 115645308A CN 202211329361 A CN202211329361 A CN 202211329361A CN 115645308 A CN115645308 A CN 115645308A
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- Prior art keywords
- ceramide
- skin
- hyaluronate
- salt
- composition
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- 239000000203 mixture Substances 0.000 title claims description 53
- 239000002537 cosmetic Substances 0.000 title claims description 16
- 108010020346 Polyglutamic Acid Proteins 0.000 claims abstract description 45
- 229940106189 ceramide Drugs 0.000 claims abstract description 40
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 36
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 36
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 36
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 36
- 150000003839 salts Chemical class 0.000 claims abstract description 32
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 22
- 229920002643 polyglutamic acid Polymers 0.000 claims abstract description 18
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 17
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 17
- -1 acetyl chitosamine Chemical compound 0.000 claims abstract description 12
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 claims description 33
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims description 28
- 229940014041 hyaluronate Drugs 0.000 claims description 28
- 239000011734 sodium Substances 0.000 claims description 14
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 12
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 12
- 229910052708 sodium Inorganic materials 0.000 claims description 12
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 12
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 12
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims description 8
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 claims description 8
- 239000011575 calcium Substances 0.000 claims description 8
- 239000011777 magnesium Substances 0.000 claims description 7
- 230000003020 moisturizing effect Effects 0.000 claims description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 6
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 6
- 229910052791 calcium Inorganic materials 0.000 claims description 6
- 229910052749 magnesium Inorganic materials 0.000 claims description 6
- 239000011591 potassium Substances 0.000 claims description 6
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- BBAFBDLICMHBNU-MFZOPHKMSA-N N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC BBAFBDLICMHBNU-MFZOPHKMSA-N 0.000 claims description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 4
- GCDXVKZXCQGDHC-BLCQCPAESA-N [30-oxo-30-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]triacontyl] (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC GCDXVKZXCQGDHC-BLCQCPAESA-N 0.000 claims description 4
- 229910017052 cobalt Inorganic materials 0.000 claims description 4
- 239000010941 cobalt Substances 0.000 claims description 4
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052737 gold Inorganic materials 0.000 claims description 4
- 239000010931 gold Substances 0.000 claims description 4
- VJVOFLWZDWLHNR-MRCUWXFGSA-N icosan-9-yl (z)-docos-13-enoate Chemical compound CCCCCCCCCCCC(CCCCCCCC)OC(=O)CCCCCCCCCCC\C=C/CCCCCCCC VJVOFLWZDWLHNR-MRCUWXFGSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 229910052709 silver Inorganic materials 0.000 claims description 4
- 239000004332 silver Substances 0.000 claims description 4
- DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical compound CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 claims description 4
- CJKGLEVYDCRGBX-FQYIUYQHSA-N N-(30-(9Z,12Z-octadecadienoyloxy)-tricontanoyl)-sphing-4-enine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC CJKGLEVYDCRGBX-FQYIUYQHSA-N 0.000 claims description 3
- KZTJQXAANJHSCE-OIDHKYIRSA-N N-octodecanoylsphinganine Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)CCCCCCCCCCCCCCC KZTJQXAANJHSCE-OIDHKYIRSA-N 0.000 claims description 3
- 229940086668 ceramide eop Drugs 0.000 claims description 3
- 229940092542 ceramide eos Drugs 0.000 claims description 3
- BUDNAJYVCUHLSV-ZLUOBGJFSA-N Ala-Asp-Ser Chemical compound C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O BUDNAJYVCUHLSV-ZLUOBGJFSA-N 0.000 claims description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 21
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- 230000014759 maintenance of location Effects 0.000 abstract description 2
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- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
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- 230000001681 protective effect Effects 0.000 description 2
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- 238000010998 test method Methods 0.000 description 2
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 description 1
- GBGUSZWBYGKEBA-VBYMIUBRSA-N (2R)-2-hydroxy-N-[(E,2S,3R,6R)-1,3,6-trihydroxyoctadec-4-en-2-yl]tetracosanamide Chemical compound CCCCCCCCCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@@H](CO)[C@H](O)\C=C\[C@H](O)CCCCCCCCCCCC GBGUSZWBYGKEBA-VBYMIUBRSA-N 0.000 description 1
- 241000192705 Aphanothece Species 0.000 description 1
- 240000007087 Apium graveolens Species 0.000 description 1
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 1
- 235000010591 Appio Nutrition 0.000 description 1
- 241000218645 Cedrus Species 0.000 description 1
- WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 description 1
- 229930182847 D-glutamic acid Natural products 0.000 description 1
- 206010052139 Eye oedema Diseases 0.000 description 1
- 240000006927 Foeniculum vulgare Species 0.000 description 1
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Chemical group O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
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- 241000168517 Haematococcus lacustris Species 0.000 description 1
- 241000720991 Illicium Species 0.000 description 1
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- WAYLDHLWVYQNSQ-KEFDUYNTSA-N N-2-hydroxylignoceroylsphingosine Chemical compound CCCCCCCCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)\C=C\CCCCCCCCCCCCC WAYLDHLWVYQNSQ-KEFDUYNTSA-N 0.000 description 1
- ZBQZXOVJGDSANU-SPUWTEBASA-N N-[(E,2S,3R,6R)-1,3,6-trihydroxyoctadec-4-en-2-yl]tetracosanamide Chemical compound CCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)\C=C\[C@H](O)CCCCCCCCCCCC ZBQZXOVJGDSANU-SPUWTEBASA-N 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- 102000011842 Serrate-Jagged Proteins Human genes 0.000 description 1
- 108010036039 Serrate-Jagged Proteins Proteins 0.000 description 1
- MIUIRGGKIICMBP-NFOZDHADSA-N [27-oxo-27-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]heptacosyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC MIUIRGGKIICMBP-NFOZDHADSA-N 0.000 description 1
- ZGBFGAHZKZQSLG-UMCOJZBLSA-N [30-oxo-30-[[(e,2s,3r,6r)-1,3,6-trihydroxyoctadec-4-en-2-yl]amino]triacontyl] (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCC[C@@H](O)\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC ZGBFGAHZKZQSLG-UMCOJZBLSA-N 0.000 description 1
- NTMADBCZHNCQCJ-UHFFFAOYSA-N [SiH3]O.N1(C)C(=O)N(C)C=2N=CN(C)C2C1=O Chemical compound [SiH3]O.N1(C)C(=O)N(C)C=2N=CN(C)C2C1=O NTMADBCZHNCQCJ-UHFFFAOYSA-N 0.000 description 1
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- AEMOLEFTQBMNLQ-WAXACMCWSA-N alpha-D-glucuronic acid Chemical group O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-WAXACMCWSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
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- 229940041514 candida albicans extract Drugs 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229940048864 ceramide 1 Drugs 0.000 description 1
- 229940099417 ceramide 2 Drugs 0.000 description 1
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- 229940069826 chlorella vulgaris extract Drugs 0.000 description 1
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Images
Abstract
The application discloses the effects of comprising the acetyl chitosamine, the hyaluronic acid or the salt thereof, the polyglutamic acid or the salt thereof and the ceramide, repairing skin barriers, improving the moisture content of skin horny layers and the moisture retention and preservation capacity of the skin.
Description
Technical Field
The application relates to the technical field of cosmetics, in particular to a cosmetic composition with moisturizing and repairing effects and application thereof.
Background
The natural barrier of the skin refers to a brick wall structure consisting of stratum corneum cells, lipid among the cells and natural moisturizing factors, and a skin lipid membrane is attached to the surface of the brick wall structure, so that a natural protective barrier of a human body is formed together. However, the natural protective barrier is easily damaged, and the skin barrier is damaged due to night stay, over-cleaning, improper sun protection, abuse of skin care products and improper medical and aesthetic repair, so that the epidermis is too quickly drained, the skin is easily dried, and part of the skin has stabbing pain and the like.
CN 110101740B discloses a skin repairing composition and a preparation thereof, wherein the composition mainly comprises polysaccharide of Aphanothece purpurea, chlorella vulgaris extract, haematococcus pluvialis extract, illicium pseudo-anise leaf extract and Glycine max seed extract, has good protection of epidermal cells, and obviously improves the moisture content, the elasticity and the glossiness of skin.
CN 111297760B discloses a composition with repairing effect, which mainly comprises 6-18 parts of African chinaberry bark extract, 1-8 parts of celery coastal callus culture filtrate, 1.5-7 parts of fennel callus culture filtrate, 3-10 parts of Relexium, 1-7 parts of WKPep Descarin G, 20-35 parts of polyhydric alcohol and 29-43 parts of water.
CN 113413338A discloses an eye-repairing composition and a preparation method and application thereof, wherein the effects achieved by compounding a hydrolyzed yeast extract, a north non-cedar bark extract and caffeine silanol are obviously superior to those achieved by single or simple combination, and the composition has the effects of reducing eye edema, resisting water retention, enhancing skin elasticity, calming and strongly moistening skin and lightening dark circles.
With the continuous improvement of skin care consciousness and living standard of people, more and more people begin to pay attention to the health condition of skin, and except for nursing the skin of the face, the hand and foot nursing gradually enters the visual field of consumers. The hand is used as the position which is most contacted with the outside when the hand is used most, and the skin barrier is easily damaged, so that skin problems such as roughness, dryness, peeling and the like are caused. Although the foot is not exposed to the environment often, prolonged rubbing can result in a rough, chapped heel. Consumers have stronger and stronger requirements on hand and foot skin care, and the market of hand and foot products with repairing efficacy is getting bigger and bigger.
Disclosure of Invention
The present application provides a cosmetic composition that increases the moisture content of the stratum corneum of the skin and improves the water-holding and moisturizing ability of the skin.
Specifically, the technical scheme adopted by the application is as follows,
1. a cosmetic composition comprises chitosamine, hyaluronic acid or its salt, polyglutamic acid or its salt and ceramide.
2. The composition according to the above-mentioned item 1,
0.05 to 5 parts by weight of the chitosamine, 0.005 to 0.2 part by weight of the hyaluronic acid or salt thereof, 0.005 to 0.1 part by weight of the polyglutamic acid or salt thereof, and 0.0005 to 0.5 part by weight of the ceramide per 100 parts by weight of the composition.
3. The composition according to any one of items 1 to 2, wherein the hyaluronic acid salt comprises any one or more of sodium hyaluronate, potassium hyaluronate, zinc hyaluronate, calcium hyaluronate, silver hyaluronate, gold hyaluronate, magnesium hyaluronate, cobalt hyaluronate, and tetrabutylammonium hyaluronate.
4. The composition according to any one of items 1 to 3, wherein the molecular weight of the hyaluronic acid or the salt thereof is 0.1MDa to 2MDa.
5. The composition according to any one of items 1 to 4, wherein the polyglutamate comprises one or more of sodium polyglutamate, potassium polyglutamate, magnesium polyglutamate, calcium polyglutamate, polyglutamic amine and zinc polyglutamate.
6. The composition of any one of items 1 to 5, wherein the ceramide comprises one or more of ceramide NP, ceramide NH, ceramide AH, ceramide NDS, ceramide AS, ceramide AP, ceramide NS, ceramide EOS, ceramide EOH, ceramide ADS, ceramide EOP, and ceramide EODs.
7. Use of the composition of any one of items 1 to 6 for moisturizing and repairing.
8. Use of the composition of any one of items 1 to 6 in a skin care product.
9. A cosmetic method comprising the steps of: applying the composition of items 1-6 to the skin.
Effects of the invention
1. The cosmetic composition provided by the application realizes the effects of repairing skin barriers, improving the moisture content of skin horny layers and improving the water-locking and moisture-keeping capacities of the skin, and experimental results show that the composition can effectively reduce the percutaneous moisture loss of hand and foot skins, parameters of skin scales, improve the moisture content of the horny layers and improve the smoothness and roughness of the skin, so that the problem of dry skin is improved, and the skin becomes soft and fine.
2. The raw materials used in the cosmetic composition are commonly used in skin care products, are easily available, can obtain an obvious repairing effect by using a small amount of raw materials, and can be widely applied to cosmetics of different systems.
Drawings
The drawings are included to provide a further understanding of the application and are not to be construed as limiting the application. Wherein:
fig. 1 is a skin texture map of three subjects using the foot membranes prepared in example 1, for 0 day (D0), 14 days (D14), and 28 days (D28), respectively.
Detailed Description
The following description of exemplary embodiments of the present application is provided to facilitate the understanding of the various details of the embodiments of the present application and are to be considered exemplary only. Accordingly, those of ordinary skill in the art will recognize that various changes and modifications of the embodiments described herein can be made without departing from the scope and spirit of the present application. Also, descriptions of well-known functions and constructions are omitted in the following description for clarity and conciseness.
Provided is a cosmetic composition comprising chitosamine, hyaluronic acid or a salt thereof, polyglutamic acid or a salt thereof, and ceramide.
The acetyl chitosamine is a basic composition unit of many important polysaccharides in biological cells, is a multifunctional humectant and a keratinocyte metabolism agent, and can accelerate skin metabolism.
The hyaluronic acid refers to a biopolymer material consisting of repeating units of N-acetyl-D-glucosamine and D-glucuronic acid, which are linearly linked. The hyaluronic acid or salt thereof is intended to include hyaluronic acid itself, a salt thereof, or a combination thereof. Examples of hyaluronic acid salts include, but are not limited to: inorganic salts such as sodium hyaluronate, potassium hyaluronate, calcium hyaluronate, magnesium hyaluronate, zinc hyaluronate, gold hyaluronate, silver hyaluronate, cobalt hyaluronate; and organic salts such as tetrabutylammonium hyaluronate. In the present application, hyaluronic acid itself or a salt thereof may be used alone, or a combination of two or more kinds of hyaluronic acid or salts thereof may be used.
The hyaluronic acid or a salt thereof described in the present application is not limited, and for example, the hyaluronic acid salt is a water-soluble salt of hyaluronic acid, which includes: any one or more of sodium hyaluronate, potassium hyaluronate, zinc hyaluronate, calcium hyaluronate, silver hyaluronate, gold hyaluronate, magnesium hyaluronate, cobalt hyaluronate, and tetrabutylammonium hyaluronate.
In some embodiments, the hyaluronic acid salt has a molecular weight of 0.2MDa to 1.5MDa, for example, can be 0.3MDa, 0.4MDa, 0.5MDa, 0.6MDa, 0.7MDa, 0.8MDa, 0.9MDa, 1.0MDa, 1.1MDa, 1.2MDa, 1.3MDa, 1.4MDa.
The molecular weight of the sodium hyaluronate is 0.2MDa to 1.5MDa, and may be, for example, 0.3MDa, 0.4MDa, 0.5MDa, 0.6MDa, 0.7MDa, 0.8MDa, 0.9MDa, 1.0MDa, 1.1MDa, 1.2MDa, 1.3MDa, and 1.4MDa.
The polyglutamic acid (gamma-polyglutamic acid, english: poly-gamma-Glutamic acid, short for gamma-PGA) is formed by polymerizing D-Glutamic acid and L-Glutamic acid through gamma-glutamyl bonds, so that a polypeptide macromolecule is formed, and the general molecular weight is 10-2000 kDa. The polyglutamic acid or salt thereof in the present application may be any polyglutamic acid or salt thereof, including, but not limited to, polyglutamic acid (A)γ -PGA, H form), na + Polyglutamates of the form K + Polyglutamate salt and NH 4 + Polyglutamate, mg in form 2+ Polyglutamates and/or Ca in form 2+ Polyglutamate and/or cross-linked gamma-polyglutamate hydrogel (formed from Na) + Polyglutamates of form K + Polyglutamate, NH in form 4 + Polyglutamate salt in form of Mg 2+ Polyglutamates and/or Ca in form 2+ Prepared with polyglutamate in form), in some embodiments, the polyglutamic acid or salt thereof is Na + Polyglutamate in the form of polyglutamate, i.e. sodium polyglutamate. The polyglutamic acid or salt thereof of the present application has a molecular weight of 1-200wDa, for example, 1wDa, 5wDa, 10wDa, 15wDa, 20wDa, 25wDa, 30wDa, 40wDa, 50wDa, 60wDa, 70wDa, 80wDa, 90wDa, 100wDa, 110wDa, 120wDa, 130wDa, 140wDa, 150wDa, 160wDa, 170wDa, 180wDa, 190wDa, and in a specific embodiment, 100wDa-180wDa.
The sodium polyglutamate is formed by ionizing carboxyl on a side chain of a glutamic acid unit body of polyglutamic acid to form anion Carboxylate (COO) - ) And then combining with sodium ions to form a product. The polyglutamic acid sodium has good moisture retention.
In some embodiments, the chitosamine, hyaluronic acid or salt thereof, and polyglutamic acid or salt thereof as described above are all obtained from a fermentation process.
The ceramide is a compound formed by combining sphingosine and long-chain fatty acid through an amide bond. Ceramide is a lipid substance that rapidly penetrates the skin, helps to renew the natural protective layer of the skin, reconstitutes cells, enhances the skin barrier against water loss and reduces the effects of the external environment.
The ceramides in the present application can be any kind of ceramides, and in some embodiments, the ceramides are 12 different subtypes of ceramides contained mainly in the stratum corneum of the skin, and are listed AS ceramide NP (ceramide 3), ceramide NH (ceramide 8), ceramide AH (ceramide 7), ceramide NDS (ceramide 10), ceramide AS (ceramide 5), ceramide AP (ceramide 6), ceramide NS (ceramide 2), ceramide EOS (ceramide 1), ceramide EOH (ceramide 4), ceramide ADS (ceramide 11), ceramide EOP (ceramide 9), and ceramide EODs.
The compositions of the present application may also include cosmetically acceptable components.
Such cosmetically acceptable components include, but are not limited to, solvents, emulsifiers, thickeners, antioxidants, preservatives and mildewcides, humectants, surfactants, pH adjusters, fragrances, pigments, functional aids, other skin care ingredients, and the like.
In some embodiments, the acetylcysteine amine is 0.05 to 5 parts by weight, the sodium hyaluronate is 0.005 to 0.2 parts by weight, the sodium polyglutamate is 0.005 to 0.1 parts by weight, and the ceramide is 0.0005 to 0.5 parts by weight, relative to 100 parts by weight of the composition.
In some embodiments, the amount of the acetyl chitosamine is 0.1 to 1 part by weight, the amount of the sodium hyaluronate is 0.01 to 0.08 part by weight, the amount of the sodium polyglutamate is 0.01 to 0.05 part by weight, and the amount of the ceramide is 0.001 to 0.1 part by weight, relative to 100 parts by weight of the composition.
In some embodiments, the acetylcysteine amine, the sodium hyaluronate, the sodium polyglutamate, and the ceramide are 0.3 to 0.8 parts by weight, 0.04 to 0.07 parts by weight, 0.01 to 0.03 parts by weight, and 0.03 to 0.07 parts by weight, respectively, per 100 parts by weight of the composition.
The cosmetic composition can be prepared into powder, aqua, emulsion, paste, suspension, etc.
The present application provides the use of any of the compositions described above for wet repair.
The present application further provides the use of any of the compositions as described above in a skin care product.
The skin care products include, but are not limited to, water, milk, cream, essence, sunscreen cream, oils, body refreshing products, bath products, eye skin care products, facial masks, face washing products, makeup removing products, foundation products, pressed powder products, poplites, body painting cosmetics, eyebrow pencils, eye shadows, eyelids, eye hairs, eye color makeup remover, lip protecting creams, lip gloss oils, common lip creams and lip line pens.
The synergistic effect of moisturizing and repairing can be achieved by compounding the acetyl chitosamine, the hyaluronic acid or the salt thereof, the polyglutamic acid or the salt thereof and the ceramide.
Examples
Raw materials: chitosamine, sodium hyaluronate, and sodium polyglutamate were all purchased from Huaxi Biotech Inc.; ceramide NP (Evonik Operations GmbH)
Example 1
The composition is prepared into the hand membrane/foot membrane inner material, and the preparation method of the hand membrane/foot membrane inner material comprises the following steps:
(1) Preparing phase A, wherein the components in the phase A are shown in table 1, 0.5 part of acetyl chitosamine, 0.06 part of sodium hyaluronate (1.5 MDa) and 0.01 part of sodium polyglutamate (180 wDa), and the components in the phase A are mixed and stirred uniformly as shown in table 2, heated to 75 ℃, and the water in the phase A is added to 100 percent, wherein the weight of the water remained after the weight of other components is removed based on the total weight of the phase A and the phase B;
(2) Preparing a phase B, wherein the components in the phase B are shown in table 1, 0.05 part of ceramide NP is shown in table 2, and the phase B is mixed and heated to 75 ℃;
(3) Adding the phase B into the phase A, homogenizing, and cooling to obtain the hand mask/foot mask lining.
TABLE 1 basic formulation of hand/foot film inner material
Table 2 content of each component of example and comparative example composition in hand/foot film inner material (%)
Examples 2 to 9 and comparative examples 1 to 8
Hand/foot film inserts of examples 2 to 9 and comparative examples 1 to 8 were prepared according to the method of example 1, the contents of the respective components are shown in tables 1 and 2, and the other non-mentioned portions are the same as example 1.
Blank control group
Hand/foot pack interiors were prepared according to the method of example 1, with the contents of the components shown in table 1, wherein phase a did not contain chitosamine, sodium hyaluronate, sodium polyglutamate, phase B did not contain ceramide NP, and the other non-mentioned portions were the same as in example 1.
Test examples
Test example 1 transdermal water loss test
The measuring instrument is as follows: the skin surface moisture loss tester, tewameter TM 300courage and Khazaka Germany.
The test method comprises the following steps: examples 1-9 and comparative examples 1-8 and a blank control group 31 subjects were selected, male and female, but not limited to, ages 18-55. Cleaning hands of the testee before sleeping every night, wearing the hand mask for 15-20 minutes, then picking off the testee, and uniformly smearing the hand mask until the hand mask is absorbed. Used 1 time every three days. The whole test period can not be used for long-time sun exposure, outdoor exercises, traveling and the like, cosmetics or medicines with similar product efficacy can not be used in the whole test period, and the test subject can not change the daily care habit in the test period. The test is carried out on the 14 th day and the 28 th day, and the test environment is 20.3-21.8 ℃ of temperature, 44.6-51.3% of humidity.
The test results of the change rate of the percutaneous water loss after the hand mask product is used for 14 days and 28 days are shown in the table 3, wherein the calculation formula of the change rate of the percutaneous water loss is as follows:
rate of change in percutaneous water loss = (amount of percutaneous water dispersion lost after use-amount of percutaneous water dispersion lost before use)/amount of percutaneous water dispersion lost before use × 100%
TABLE 3 test results of the change rate of the percutaneous Water loss
As can be seen from the data in Table 3, the hand film products prepared by using the composition of the present application, for example, 1-9, 14 days and 28 days, have significantly reduced moisture loss rate through skin on the back of the hand of the subject, which indicates that the moisture evaporation amount from the skin surface is reduced after using the composition product, and the effect is significantly better than the effect obtained by adding the components in the comparative example, which indicates that the skin barrier function is improved and the skin care effect is very good.
Test example 2 skin Scale parameter SEsc test
An experimental instrument: skin texture analysis system Visioscan VC20.
The test method comprises the following steps: examples 1-9 and comparative examples 1-8 and a blank control group 33 subjects were selected, each of which was male and female, but was 18-55 years old. Cleaning feet with clear water, wiping the feet dry, opening the package, wearing a foot film, gently massaging the feet to promote the absorption of essence, taking down the feet after 15 minutes, cleaning the feet, and wiping the feet dry. It is administered 2-3 times per week for 4 weeks. The test is carried out on the 14 th day and the 28 th day, and the test environment is 20-22 ℃ of temperature and 40-60% of humidity RH.
The SEsc test results of the skin scale parameters of the heel part after 14 days and 28 days of use of the product are shown in the table 4, wherein the calculation formula of the change rate of the skin scale parameters is as follows:
skin scale parameter change rate = (after use skin scale parameter value-before use skin scale parameter value)/before use skin scale parameter value × 100%
TABLE 4 skin Scale parameter Change Rate test results
As can be seen from the above table, the foot membrane products prepared by using the composition of the present application, as in examples 1 to 9, after 28 days, have significantly reduced skin scales on the feet of the subjects, and the effect is significantly better than the effect obtained by adding the components in the comparative examples, which indicates that the skin metabolism is accelerated, the skin barrier is restored, and the skin condition is significantly improved.
Test example 3 testing of moisture content of horny layer
An experimental instrument: corneometer CM825 Courage & Khazaka, germany). The test subjects, the product use requirements and the test environment were the same as those in test example 1. Measurement requirements: testing for 6 times, taking an average value, and calculating the moisture change rate of the stratum after use, wherein the calculation formula is as follows:
stratum corneum moisture change rate = (using posterior stratum moisture content-using anterior stratum moisture content)/using anterior stratum moisture content × 100%
31 subjects selected from examples 1 to 9 and comparative examples 1 to 8 and the blank control were treated with the hand mask product for 14 days, and the moisture change rate of the hand horny layer after 28 days was shown in Table 5.
TABLE 5 test results of moisture change rate of horny layer of hands
The results of the rate of change of water content in the horny layer of the feet after 14 days and 28 days using the foot mask product are shown in Table 6 for 33 subjects selected from examples 1 to 9 and comparative examples 1 to 8 and the blank control group, respectively.
TABLE 6 test results of moisture change rate of horny layer of foot
As can be seen from Table 5,6, whether the compositions of the present application were used to prepare hand or foot mask products as in examples 1-9, the moisture content of the stratum corneum was significantly increased after the subjects used the products for 14 and 28 days, and the effect was significantly better than the effect of the comparative example after the components were added, which indirectly confirmed the repairing effect of the compositions. The evaporation and the loss of skin moisture are reduced, the water content of the skin is improved, and the skin becomes moist and full.
Test example 4 skin smoothness test
An experimental instrument: visioscan VC20 plus Courage & Khazaka, germany. Measurement requirements: the images are collected for 1 time, the images are analyzed for 1 time, and the using requirements and the testing environment of the testee and the product are the same as those of the experimental example 1.
The results of the SEsm test for skin smoothness of the hands of subjects after 28 days using the hand film product are shown in table 7. The skin smoothness SEsm change rate calculation formula is as follows:
skin smoothness SEsm rate of change = (skin smoothness after use SEsm-skin smoothness before use SEsm)/skin smoothness before use SEsm × 100%
TABLE 7 skin smoothness SEsm Rate test results
Test example 5 skin roughness SEr test
An experimental instrument: visioscan VC20 Plus Courage & Khazaka, germany. Measurement requirements: the images are collected for 1 time, the images are analyzed for 1 time, and the using requirements and the testing environment of the testee and the product are the same as those of the experimental example 1.
The results of the product using 14 days, skin roughness after 28 days SEr test are shown in Table 8. The SEr change rate calculation formula of the skin roughness is as follows:
skin roughness sur rate of change = (after use skin roughness sur-before use skin roughness sur)/before use skin roughness sur × 100%
TABLE 8 skin roughness SEr Rate of Change test results
As can be seen from tables 7 and 8, the hand mask products prepared by using the composition of the present application, as shown in examples 1 to 9, 14 and 28 days later, the skin smoothness of the subjects was improved, the skin smoothness was smoothed, the skin roughness was improved to a large extent, and the effect was significantly better than that of the comparative examples after the components were added, which indicates that the skin metabolism was accelerated and the skin condition was better, further confirming that the composition has a repairing effect.
Meanwhile, photographs of skin texture tests of three subjects selected from the subjects using the foot mask products prepared in example 1 are shown in fig. 1, and it can be seen from the figures that skin textures of the three subjects become gradually clear at 14 days and 28 days after the foot mask products prepared in example 1 of the present application are used, indicating that the skin roughness is improved.
Test example 6 self-evaluation of subjects
The products of 31 hand film subjects who used the hand film products prepared in example 1 were collected using self-evaluation results, and the self-evaluation feedback results are shown in table 9.
TABLE 9 self-evaluation feedback results for skin condition 28 days after product application
As can be seen from the self-evaluation results feedback of table 9, more than 96.77% of the subjects using the product containing the composition of chitosamine, sodium hyaluronate, sodium polyglutamate and ceramide NP considered the product to improve dry hand skin 28 days later. The hand skin roughness, the hand skin smoothness, the hand softness, the hand fineness and the like are obviously improved and the hand skin overall state becomes good in 100% of subjects, so that the composition has a good moisturizing and repairing effect no matter from objective data results or subjective feeling evaluation in experimental examples.
While embodiments of the present application have been described above in connection with specific embodiments thereof, the present application is not limited to the above-described embodiments and fields of application, which are intended to be illustrative, instructive, and not restrictive. Those skilled in the art, having the benefit of this disclosure, may effect numerous modifications thereto and changes may be made without departing from the scope of the invention as defined by the appended claims.
Claims (9)
1. A cosmetic composition comprising an acetyl chitosamine, hyaluronic acid or a salt thereof, polyglutamic acid or a salt thereof, and a ceramide.
2. The composition of claim 1,
0.05 to 5 parts by weight of the chitosamine, 0.005 to 0.2 part by weight of the hyaluronic acid or salt thereof, 0.005 to 0.1 part by weight of the polyglutamic acid or salt thereof, and 0.0005 to 0.5 part by weight of the ceramide per 100 parts by weight of the composition.
3. The composition according to any one of claims 1 to 2, wherein the hyaluronic acid salt comprises any one or more of sodium hyaluronate, potassium hyaluronate, zinc hyaluronate, calcium hyaluronate, silver hyaluronate, gold hyaluronate, magnesium hyaluronate, cobalt hyaluronate, tetrabutylammonium hyaluronate.
4. The composition according to any one of claims 1 to 3, wherein the hyaluronic acid or salt thereof has a molecular weight of 0.1MDa to 2MDa.
5. The composition according to any one of claims 1 to 4, wherein the polyglutamate comprises one or more of sodium polyglutamate, potassium polyglutamate, magnesium polyglutamate, calcium polyglutamate, polyglutamamine, and zinc polyglutamate.
6. The composition of any one of claims 1 to 5, wherein the ceramide comprises one or more of ceramide NP, ceramide NH, ceramide AH, ceramide NDS, ceramide AS, ceramide AP, ceramide NS, ceramide EOS, ceramide EOH, ceramide ADS, ceramide EOP, and ceramide EODs.
7. Use of a composition according to any one of claims 1 to 6 for moisturizing and repairing.
8. Use of a composition according to any one of claims 1 to 6 in a skin care product.
9. A cosmetic method comprising the steps of: applying the composition of claims 1-6 to the skin.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108685741A (en) * | 2018-08-06 | 2018-10-23 | 广州国宇医药科技有限公司 | It is a kind of promote skin barrier reparation composition and its application |
| CN111686033A (en) * | 2020-06-02 | 2020-09-22 | 华熙生物科技股份有限公司 | Diversified functional compound composition containing hyaluronic acid or salt thereof and application thereof |
| CN114699338A (en) * | 2022-04-14 | 2022-07-05 | 华熙生物科技股份有限公司 | Skin care composition, application thereof and skin care product |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108685741A (en) * | 2018-08-06 | 2018-10-23 | 广州国宇医药科技有限公司 | It is a kind of promote skin barrier reparation composition and its application |
| CN111686033A (en) * | 2020-06-02 | 2020-09-22 | 华熙生物科技股份有限公司 | Diversified functional compound composition containing hyaluronic acid or salt thereof and application thereof |
| CN114699338A (en) * | 2022-04-14 | 2022-07-05 | 华熙生物科技股份有限公司 | Skin care composition, application thereof and skin care product |
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