CN115607360A

CN115607360A - Medicine depthkeeping conveyor

Info

Publication number: CN115607360A
Application number: CN202110914399.4A
Authority: CN
Inventors: 洪颖; 张纯; 宋思佳; 陈旭豪
Original assignee: Peking University Third Hospital Peking University Third Clinical Medical College
Current assignee: Peking University Third Hospital Peking University Third Clinical Medical College
Priority date: 2021-08-10
Filing date: 2021-08-10
Publication date: 2023-01-17

Abstract

The present disclosure relates to a drug depthkeeping delivery device, comprising: the conveying part is provided with an accommodating structure, the accommodating structure is used for accommodating medicaments, the needle head is connected with the accommodating structure, and the positioning part is sleeved on the needle head and provided with a positioning structure and scales arranged at the bottom end of the positioning structure, the positioning structure comprises a first positioning structure and a second positioning structure, the first positioning structure and the second positioning structure are overturned towards the radial outer side of the body relative to the body, a first opening is arranged between the first positioning structure and the body, a second opening is arranged between the second positioning structure and the body, and the first opening is opposite to the opening of the second opening. This is disclosed through being provided with location structure and having the location portion of scale, under the condition of carrying the medicament to choroid and sclera lacuna space, combines the sclera thickness that measures in advance, can fix location portion to the desired position, has realized the effect that the high accuracy depthkeeping was carried.

Description

Medicine depthkeeping conveyor

Technical Field

The disclosure relates to the technical field of medical appliances, in particular to a medicine depth-fixing conveying device.

Background

The eyeball is a very delicate tissue organ of human beings, with a diameter of about 22mm-24mm. The outer layer of the eyeball is a layer of eyeball wall tissue, and the inner layer is filled with aqueous humor and vitreous tissues of a water sample. In short, like a balloon filled with water, or a camera. Since the inside of the eyeball is free of blood vessels for maintaining a transparent optical system, nutrition for the intraocular tissue is supplied through the eyeball wall tissue. Therefore, the eyeball can be administered after getting a disease by selectively injecting the drug into the eyeball through the eyeball wall tissue.

The eye wall tissue is divided into three layers, including the outermost sclera (tough), the middle choroid (rich in blood vessels), and the innermost retina (imaging and visual signal transmission). The sclera is the copper wall and iron wall which protects the eyeball tissue, and the choroid is used for conveying nutrition and discharging waste; are all for retinal services. Thus, retinal diseases or scientific studies can be performed by injecting drugs into the eye from the scleral side.

Currently, there are two ways to inject drugs into the eye. One is to make the needle penetrate all three layers of tissues directly to reach the inside of the eyeball, so that the liquid medicine is metabolized quickly and the medicine effect is maintained for a short time. Another way is that the tip of the needle reaches under the choroid, which is similar to subcutaneous injection of slow release drugs, which can last a long time. However, choroidal tissue is a rich layer of vascular tissue that, once the needle tip breaks through the blood vessel during injection, can cause excessive bleeding, harm the patient and affect the injection of the agent.

Disclosure of Invention

To overcome the problems in the related art, the present disclosure provides a medication depthkeeping delivery device.

According to an embodiment of the present disclosure, there is provided a medication depthkeeping device, including:

a delivery portion including an accommodation structure for accommodating a medicament;

the needle head is connected with the accommodating structure;

the positioning part is sleeved on the needle head and comprises a body, and scales are arranged on the body;

the positioning part further comprises a positioning structure, the positioning structure comprises a first positioning structure and a second positioning structure, the first positioning structure and the second positioning structure are opposite to the body and face towards the radial outer side of the body, a first opening is formed between the first positioning structure and the body, a second opening is formed between the second positioning structure and the body, and the first opening and the second opening face opposite to each other.

Optionally, the first opening faces the needle and the second opening faces the delivery portion.

Optionally, the positioning structures include at least two first positioning structures, and the at least two first positioning structures are uniformly distributed along the circumferential direction of the body;

the positioning structure comprises at least two second positioning structures, and the second positioning structures are uniformly distributed along the circumferential direction of the body.

Optionally, the first positioning structure and the second positioning structure are disposed on a side close to the bottom end of the body.

Optionally, the positioning portion further includes a plurality of through holes, and the through holes penetrate through the side wall of the body;

the positioning part also comprises a one-way valve, and the through hole is arranged between the one-way valve and the positioning structure;

the conduction direction of the one-way valve is opposite to the injection direction of the medicament.

Optionally, a plurality of the through holes are uniformly distributed along the circumferential direction of the body.

Optionally, a pressure sensing unit is disposed on the needle.

Optionally, an illumination unit is provided on the needle.

Optionally, the conveying part further comprises a driving structure, and the driving structure is connected with the accommodating structure.

Optionally, the front end of the needle has a bevel inclined at a preset angle to the axis of the body, the preset angle being 45 ° ± 5 °.

The technical scheme provided by the embodiment of the disclosure can have the following beneficial effects: this is disclosed has location structure and the location portion of scale through setting up the detachable, under the condition of carrying the medicament to the lacunar space between choroid and sclera, combines the sclera thickness that measures in advance, can fix location portion to the desired position, has realized the effect that the depthkeeping of high accuracy was carried.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the disclosure.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and together with the description, serve to explain the principles of the invention.

Fig. 1 is a schematic view of a medication depthkeeping delivery device according to an exemplary embodiment.

Fig. 2 is a partial schematic view of a medication depthkeeping delivery device according to an exemplary embodiment.

Fig. 3 is a partial schematic view of a medication depthkeeping delivery device according to an exemplary embodiment.

Fig. 4 is a partial schematic view of a medication depthkeeping delivery device according to an exemplary embodiment.

Detailed Description

Reference will now be made in detail to the exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, like numbers in different drawings represent the same or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present invention. Rather, they are merely examples of apparatus and methods consistent with certain aspects of the invention, as detailed in the appended claims.

Currently, there are two ways to deliver drugs into the eye.

In the first mode, the needle penetrates all three layers of tissue directly to reach the inside of the eyeball and injects the medicine, but the medicine is metabolized quickly and remains for a short time.

The second way is to have the needle tip reach under the choroid, which is maintained for a long period of time, just like injecting a slow release medication subcutaneously. However, choroidal tissue is a rich layer of vascular tissue that bleeds profoundly once the blood vessels are breached. In which a potential compartment exists between the choroid and scleral tissues, like clothing and linings, which are normally held together and can be separated by a twist. Therefore, many studies hope that drugs can be injected into this layer of cavities. The injection method can not cause bleeding, and can be maintained for a long time without damaging other tissues. The sclera is only a few millimeters thick, and ensuring that the sclera is properly penetrated without damaging the choroid is a technical difficulty.

In order to solve the above problems, the present disclosure provides a medicine depthkeeping conveying device, which includes a conveying portion having an accommodating structure, a needle connected to the accommodating structure, and a positioning portion sleeved on the needle, wherein the accommodating structure is used for accommodating a medicine. The positioning part comprises a body with scales and a positioning structure, the positioning structure comprises a first positioning structure and a second positioning structure, the first positioning structure and the second positioning structure are turned towards the radial outer side of the body relative to the body, namely, the positioning structure protrudes out of the outer side wall of the body, when the needle penetrates into the eyeball, the positioning structure protruding out of the outer side wall of the body can be fixed on the tough sclera, a first opening is arranged between the first positioning structure and the body, a second opening is arranged between the second positioning structure and the body, the first opening and the second opening are opposite in opening direction, the first positioning structure and the second positioning structure which are opposite in opening direction can be respectively fixed on the outer wall and the inner wall of the sclera, the first positioning structure can limit the positioning part to continuously penetrate into the choroid, the positioning part can penetrate into the eyeball when the positioning part reaches a desired position, the first positioning structure can not continuously penetrate into the outer side wall of the body due to the protrusion, the positioning structure can not continuously penetrate into the outer side wall of the body in combination with the measured sclera thickness in a B-exceeding mode, the process that the conveying part drives the needle to penetrate into the eyeball, and accordingly, the positioning part can roughly judge the depth of the positioning part when the positioning effect of deep injection is achieved.

According to an exemplary embodiment, the present embodiment provides a medicament depthkeeping delivery device, which comprises a delivery part 1, a needle 2 and a positioning part 3, as shown in fig. 1. The conveying part 1 comprises an accommodating structure 11 for accommodating the medicament, the accommodating structure 11 is connected with the needle 2, and the connecting mode can be fixed connection or can be installed together through a connecting structure.

In this embodiment, as shown in fig. 1, the conveying part 1 is a syringe, the conveying part 1 includes an accommodating structure 11 and a driving structure 12 slidably connected to the accommodating structure 11, the driving structure 12 and the accommodating structure 11 cooperate to form an accommodating space 13, and the accommodating space 13 has 1 opening, that is, the needle 2 connected to the accommodating structure 11. The accommodating structure 11 further includes a push plate 111, and the driving structure 12 can slide in the accommodating structure 11 under the action of an external force. Taking the orientation shown in fig. 1 as an example, when the medicine is not contained in the containing structure 11, the needle 2 is inserted into the medicine bottle, the driving structure 12 moves upward under the action of external force, the pressure in the containing space 13 becomes smaller, and the pressure in the medicine bottle is greater than the pressure in the containing space 13, so that the medicine enters the containing space 13. Taking the orientation shown in fig. 1 as an example, during injection, the holding structure 11 inserts the needle 2 and the positioning portion 3 into a predetermined position, the external force acts on the push plate 111 and the driving structure 12 on the holding structure 11, and the driving structure 12 is pushed downwards and slowly, so as to deliver the medicament in the holding space 13 to a desired position in the eyeball.

In some possible embodiments, the containing structure 11 may be an infusion bottle, and the driving structure 12 is used to communicate and balance the pressure inside the containing structure 11 with the external atmospheric pressure, the pressure at the needle 2 is greater than the pressure inside the eyeball, and the medicament is subjected to gravity, so that the medicament can be delivered into the eyeball through the needle 2.

As shown in fig. 2 and 3, the positioning portion 3 includes a body 31 having a scale 35 and a positioning structure 32 provided on the body 31. The zero scale of the scale 35 is located at the bottom end of the positioning portion 3, and the scale 35 is provided to show the depth of the positioning portion 3 into the sclera. Wherein, scale 35 sets up in location portion 3 surface, if set up inside location portion 3, the reading angle difference probably produces the error, leads to inserting the degree of depth incorrect, threatens patient's safety even. The positioning structure 32 is used for limiting when the positioning part 3 reaches a predetermined position and fixing the positioning part 3, so as to protect the choroid from being punctured and damaged by the positioning part 3 and the needle 2. The positioning portion 3 may be made of a silicon gel or a metal material.

As shown in fig. 3, the positioning structure 32 includes a first positioning structure 321 and a second positioning structure 322, and the first positioning structure 321 and the second positioning structure 322 are turned toward the radial outer side of the body 31 relative to the body 31, that is, the positioning structure 32 protrudes from the outer side wall of the body 31. When the needle 2 is inserted into the eyeball, the first positioning structure 321 has an opening facing downward and protruding from the body 31, and when the first positioning structure 321 contacts the outer wall of the sclera, the protruding first positioning structure 321 can be fixed on the tough sclera to limit the insertion of the positioning part 3, thereby having a limiting effect. The first opening 3211 is arranged between the first positioning structure 321 and the body 31, the second opening 3221 is arranged between the second positioning structure 322 and the body 31, the first opening 3211 and the second opening 3221 are opposite in opening direction, the first positioning structure 321 and the second positioning structure 322 which are opposite in opening direction can be respectively fixed on the outer wall and the inner wall of the sclera, the first positioning structure 321 can limit the positioning portion 3 from further penetrating into the eyeball to damage the choroid, the second positioning structure 322 is fixed on the inner wall of the sclera, so as to prevent the positioning portion 3 from separating from the sclera, in combination with the sclera thickness of the patient measured by the type B ultrasonic method, in the process of pushing the conveying portion 1 to drive the needle into the eyeball, the positioning portion 3 can penetrate into the eyeball, the depth of the positioning portion 3 can be roughly judged by the scale 35 on the positioning portion 3, when the expected position is reached, the first positioning structure 321 protrudes out of the outer side wall of the body 31, so that the first positioning structure 321 is fixed on the outer wall of the sclera, so as to limit the positioning portion 3 from further, and the second positioning structure 322 fixed on the inner wall of the sclera can prevent the positioning portion from falling off from the eyeball, thereby realizing the effect of the deep injection.

Taking the orientation shown in fig. 2 as an example, the first positioning structure 321 faces downward, the second positioning structure 322 faces upward, the second positioning structure 322 is located below the first positioning structure 321, and both the first positioning structure 321 and the second positioning structure 322 are disposed at positions far from the top end of the positioning portion 3.

The first positioning structure 321 and the second positioning structure 322 are disposed at positions that are supported by data, and the positions are related to the sclera thickness of the patient's eye measured by a B-ultrasonic apparatus or the like.

As shown in FIG. 3, the distance between the first positioning structure 321 and the second positioning structure 322 is slightly greater than the sclera thickness: when first location structure 321 contacted sclera outer wall, second location structure 322 opening tip had surpassed sclera inner wall, and 3 bottoms of location portion had caused the deformation in the safety range to the choroid this moment, and the relative first location structure 321 of opening direction and second location structure 322 had played the fixed action to location portion through the centre gripping to the sclera wall this moment.

As shown in fig. 3, the distance between the second positioning structure 322 and the bottom end of the positioning portion 3 is: as long as the length of the positioning part 3 protruding out of the inner wall of the sclera is ensured not to extrude and damage the choroid of the patient.

In this embodiment, the shape of the positioning structure 32 is not limited, and may be, for example, a thorn-shaped structure, a square-shaped structure, or a special-shaped structure, as long as the positioning portion 3 can be fixed and limited.

As shown in fig. 3 and 4, the positioning portion 3 is further provided with a plurality of through holes 34, the through holes 34 penetrate through the side wall of the body 31 and are uniformly distributed along the circumferential direction of the body 31, and in the vertical direction, the through holes 34 are located between the bottom end of the body 31 and the second positioning structure 322.

As shown in fig. 3 and 4, the positioning portion 3 is further provided with a check valve 33, the check valve 33 is located at the bottom end of the positioning portion 3, a plurality of through holes 34 are provided between the check valve 33 and the positioning structure 32, the check valve 33 is composed of a plurality of petals, and the plurality of petals can be tightly closed in an unstressed state. When the needle 2 passes through the positioning part 3, the petals are spread apart, and at this time, the needle 2 and the positioning part 3 have a function of clamping connection.

Taking the orientation shown in fig. 2 as an example, the conduction direction of the check valve 33 disposed in the positioning portion 3 is vertical upward, the conveying direction of the needle 2 is vertical downward, that is, the conduction direction of the check valve 33 is opposite to the conveying direction of the needle 2, referring to fig. 4, the body 31 of the positioning portion 3 is a tubular structure with two-way conduction, when the conveying portion 1 is driven to convey, the medicament in the needle 2 flows downward vertically from the top and flows downward along the inner wall of the body 31 of the positioning portion 3, the bottom end of the positioning portion 3 is in close contact with the choroid, if the check valve 33 is not disposed, a large amount of medicament can greatly impact the choroid, which causes damage to the choroid, and by disposing the check valve 33 opposite to the conveying direction, the medicament can be prevented from moving linearly along the inner wall of the body 31 of the positioning portion 3 all the time, which avoids the medicament directly impacting the choroid, thereby achieving the effect of protecting the choroid.

As shown in fig. 4, when the medicament is delivered, because the conduction direction of the one-way valve 33 is opposite to the delivery direction, when an external force is applied to the medicament in the accommodating structure 11, the medicament enters the space between the sclera and the choroid through the plurality of through holes 34, and the plurality of through holes are arranged in different directions, so that the medicament can be distributed to more positions, and in the delivery direction, the one-way valve 33 has a blocking effect on the medicament, so that the medicament does not directly impact the choroid, and the choroid is protected.

As shown in fig. 2, the needle 2 and the positioning portion 3 are detachably mounted, the inner wall of the body 31 of the positioning portion 3 is attached to the diameter of the needle 2, and the detachable mounting manner may be a friction contact, a snap, or the like, as long as the needle 2 and the positioning portion 3 can be connected or separated. When syringe needle 2 is in the assembled state with location portion 3, can drive location portion 3 through syringe needle 2 and get into the sclera, when syringe needle 2 pierces through the sclera, drive location portion 3 and move together, fix on the sclera for guaranteeing that location portion 3 can stabilize, can let location structure 32 of location portion 3 get into, external force control location portion 3 position is unchangeable this moment, pulling holding structure 11 drives syringe needle 2 and outwards removes, install syringe needle 2 and location portion 3 together again, continue to the inside propulsion of eyeball, can avoid syringe needle 2 to contact the choroid and produce the hemorrhage phenomenon, can also be with the more firm fixing in the sclera of location portion 3.

In some possible embodiments, after the positioning part 3 is fixed, the needle 2 can be taken out and positioned for bidirectional therapy. If the choroid hemorrhage or other exudates and other conditions are met, the needle head 2 can be pulled out, the positioning part 3 is of a conduction structure, redundant substances in the tissue can be released through the positioning part 3, or other treatment appliances or treatment auxiliary appliances can enter the tissue through the positioning part 3 after the needle head 2 is pulled out, and the effect of auxiliary treatment is achieved.

As shown in fig. 2, the front end of the needle 2 has a bevel inclined at a predetermined angle of 45 ° ± 5 ° with respect to the axis of the needle body, on the one hand, an excessive angle reduces the sharpness of the tip of the needle 2, which may excessively press the sclera to penetrate the sclera, when passing through the tough sclera; on the other hand, too small an angle increases the longitudinal length at the tip of the needle 2 so that the tip penetrates the sclera, but does not open a larger through-hole to the sclera so that the positioning portion 3 can enter.

As shown in fig. 2, the needle 2 includes a needle body 21 and a pressure sensing unit 22 disposed at an end close to the needle tip, and at the moment the needle 2 penetrates the sclera, the pressure sensing unit 22 does not sense the pressure, i.e. stops to go deep, so as to protect the tissue from being damaged; the pressure inside the tissue is closely related to the lesion, and the data of the pressure sensing unit 22 can be used to know whether the lesion occurs and the degree of the lesion.

As shown in fig. 2, an illumination unit 23 is disposed at one end of the needle body 2 near the needle tip, in this embodiment, the illumination unit 23 may be fiber illumination, and since the sclera tissue, the choroid and the retina tissue have certain light transmittance, the location of the delivery position can be performed by blinking red light on the outer surface of the sclera or by observing the red light transmitted by the retina through a microscope during the operation.

The specific implementation manner of this embodiment: when the device is used, the thickness of the sclera of a patient is firstly measured by a B ultrasonic instrument and the like, and the positioning part 3 is processed according to the measured value.

Processing treatment: at this time, the positioning portion 3 has the check valve 33, the through hole 34 and the scale 35, but does not have the positioning structure 32, wherein the distance between the second positioning structure 322 and the bottom end of the positioning portion 3 does not need to be determined according to the previously measured numerical value, and it is only required to ensure that the through hole 34 is not damaged, and the distance between the first positioning structure 321 and the second positioning structure 322 should be slightly larger than the previously measured numerical value, so as to ensure that the first positioning structure 321 and the second positioning structure 322 can be fixed on the outer wall and the inner wall of the sclera respectively.

After the positioning part 3 is processed, a rod-shaped object attached to the inner wall of the body 31 of the positioning part 3 is inserted along the conduction direction of the one-way valve 33, a part of the rod-shaped object is inside the positioning part 3, a part of the rod-shaped object is outside the positioning part 3, the needle 2 is inserted in the direction opposite to the conduction direction of the one-way valve 33, the rod-shaped object is butted with the needle 2, the positioning part 3 is moved along the conduction direction of the one-way valve 33, and the positioning part 3 is sleeved on the needle 2.

Wherein the rod-shaped object acts: for opening the one-way flap of the one-way valve 33 and interfacing with the needle 2, enables the transfer of the positioning part 3 onto the needle 2.

After the installation is finished, the device is inserted into the eye tissue of a patient, in the inserting process, when the sensing pressure of the pressure sensing unit 22 disappears (the sensing pressure disappears at the moment of penetration), the positioning part 3 is fixed, the accommodating structure 11 is pulled back to drive the needle head 2 and the positioning part 3 to generate relative displacement, the positioning part 3 is fixedly cancelled, and the accommodating structure 11 is pushed to drive the needle head 2 and the positioning part 3 to continue to be inserted.

After the positioning part 3 reaches a preset position, subsequent treatment is carried out according to a treatment plan, and medicines can be selectively delivered into the eyes or tissue fluid accumulated in the eyes can be discharged.

Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the embodiments disclosed herein. This application is intended to cover any variations, uses, or adaptations of the disclosure following, in general, the principles of the disclosure and including such departures from the present disclosure as come within known or customary practice within the art to which the disclosure pertains. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the invention being indicated by the following claims.

It will be understood that the invention is not limited to the precise arrangements described above and shown in the drawings and that various modifications and changes may be made without departing from the scope thereof. The scope of the invention is limited only by the appended claims.

Claims

1. A medication depthkeeping delivery device, comprising:

a delivery portion comprising an accommodation structure for accommodating a medicament;

the needle head is connected with the accommodating structure;

2. The medication depthkeeping delivery device of claim 1, wherein the first opening is toward the needle and the second opening is toward the delivery portion.

3. The device for depthkeeping transportation of medicines according to claim 1, characterized in that the positioning structures comprise at least two first positioning structures which are uniformly distributed along the circumferential direction of the body;

4. The device of any of claims 1-3, wherein the first and second locating features are disposed on a side proximate a bottom end of the body.

5. The device of claim 1, wherein the positioning portion further comprises a plurality of through holes, the through holes penetrating through the sidewall of the body;

6. The device for depthkeeping conveying of medicines according to claim 5, characterized in that a plurality of through holes are evenly distributed along the circumferential direction of the body.

7. The device for depthkeeping transportation of medicines according to claim 1, characterized in that, a pressure sensing unit is arranged on the needle head.

8. The medication depthkeeping delivery device of claim 1, wherein an illumination unit is disposed on the needle.

9. The device of claim 1, wherein the delivery portion further comprises a drive structure, the drive structure being coupled to the receiving structure.

10. The medication depthkeeping delivery device of claim 1, wherein the forward end of the needle has a bevel that is inclined at a preset angle to the axis of the body, the preset angle being 45 ° ± 5 °.