CN115583788B - Automatic micromanipulation needle drawing instrument and drawing method - Google Patents
Automatic micromanipulation needle drawing instrument and drawing method Download PDFInfo
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- CN115583788B CN115583788B CN202211310602.8A CN202211310602A CN115583788B CN 115583788 B CN115583788 B CN 115583788B CN 202211310602 A CN202211310602 A CN 202211310602A CN 115583788 B CN115583788 B CN 115583788B
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- sliding rail
- needle
- glass tube
- heating
- sliding block
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- 238000000034 method Methods 0.000 title claims abstract description 21
- 239000011521 glass Substances 0.000 claims abstract description 92
- 238000010438 heat treatment Methods 0.000 claims abstract description 87
- 238000005520 cutting process Methods 0.000 claims abstract description 35
- 238000009434 installation Methods 0.000 claims description 14
- 230000005540 biological transmission Effects 0.000 claims description 8
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical group [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 claims description 8
- 229910000831 Steel Inorganic materials 0.000 claims description 4
- 239000010959 steel Substances 0.000 claims description 4
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 4
- 229910052721 tungsten Inorganic materials 0.000 claims description 4
- 239000010937 tungsten Substances 0.000 claims description 4
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 229910000566 Platinum-iridium alloy Inorganic materials 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 16
- 239000012472 biological sample Substances 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000011068 loading method Methods 0.000 description 4
- 230000009471 action Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000002485 combustion reaction Methods 0.000 description 2
- 238000010304 firing Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 210000001161 mammalian embryo Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000005452 bending Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000013020 embryo development Effects 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- UONOETXJSWQNOL-UHFFFAOYSA-N tungsten carbide Chemical compound [W+]#[C-] UONOETXJSWQNOL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
- C03B23/00—Re-forming shaped glass
- C03B23/04—Re-forming tubes or rods
- C03B23/11—Reshaping by drawing without blowing, in combination with separating, e.g. for making ampoules
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P40/00—Technologies relating to the processing of minerals
- Y02P40/50—Glass production, e.g. reusing waste heat during processing or shaping
- Y02P40/57—Improving the yield, e-g- reduction of reject rates
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Re-Forming, After-Treatment, Cutting And Transporting Of Glass Products (AREA)
Abstract
The invention provides an automatic micromanipulation needle drawing instrument and a drawing method, and belongs to the technical field of biological sample experimental equipment production equipment. The automatic micromanipulation needle drawing instrument comprises a vertical support, a first clamping assembly, a second clamping assembly, a heating device, a needle breaking device and a controller. The first clamping assembly comprises a first sliding rail, a first sliding block, a first clamping jaw and a first driving device, the second clamping assembly comprises a second sliding rail, a second sliding block, a second clamping jaw and a second driving device, the heating device is arranged on the mounting surface and located between the first sliding rail and the second sliding rail, a heating hole for a glass tube to pass through is formed in the heating device, a heater is arranged in the heating hole, and the needle breaking device is used for cutting the glass tube located between the heating device and the second clamping jaw. By adopting the automatic micromanipulation needle drawing instrument and the drawing method, the micromanipulation needle can be automatically drawn in a flow manner in a laboratory, the preparation precision is improved, and the rejection rate is reduced.
Description
Technical Field
The invention relates to the technical field of biological sample experimental equipment production equipment, in particular to an automatic micromanipulation needle drawing instrument and a drawing method.
Background
In assisted reproductive medicine and biological embryo research, tissue samples of biological embryos often need to be collected by micromanipulation and then sent to analytical instruments such as a microscope for observation and experimental analysis. In the embryo culture process, since the embryo development is in different stages, micromanipulation needles with different tube diameters and lengths are needed for operation in the test stage. The micromanipulation needle may require on-site preparation by an experimenter for different experimental needs.
In the related art, when a tester performs a drawing operation on a micro-needle, two clamping devices with adjustable intervals are generally used to clamp both ends of a glass tube as a raw material. And then the glass tube is fired and heated by using an alcohol lamp or a liquefied gas igniter, the glass tube is drawn into different lengths and tube diameters by manually adjusting the interval of the clamping devices, and finally the glass tube is cut by using a medical grinding wheel to form a fracture, so that the usable micro-operation needle is obtained.
The glass tube is heated by adopting open flame equipment such as an alcohol lamp or a liquefied gas igniter, and the like, the temperature in the combustion process is easily affected by the external environment to cause uneven heating, and the laboratory environment is easily polluted. Meanwhile, manual stretching firing is performed by manual operation, so that the dimension deviation is easy to cause, the stretching length and the pipe diameter of the glass pipe cannot be accurately controlled, the preparation precision of the micro-operation needle is low, and the rejection rate of materials is high.
Disclosure of Invention
The embodiment of the invention provides an automatic micromanipulation needle drawing instrument and a drawing method, which can carry out flow automatic drawing on a micromanipulation needle in a laboratory, improve the preparation precision and reduce the rejection rate. The technical proposal is as follows:
in a first aspect, embodiments of the present invention provide an automatic micro-needle drawing instrument comprising:
The vertical bracket, the first clamping component, the second clamping component, the heating device, the needle breaking device and the controller are electrically connected with each other,
The vertical bracket is provided with a mounting surface;
the first clamping assembly comprises a first sliding rail, a first sliding block, a first clamping jaw and a first driving device, wherein the first sliding rail is installed on the installation surface, the first sliding rail is arranged in the vertical direction, the first sliding block is slidably installed on the first sliding rail, the first clamping jaw is installed on the first sliding block, and the first driving device is arranged on the vertical support and in transmission connection with the first sliding block;
The second clamping assembly comprises a second sliding rail, a second sliding block, a second clamping jaw and a second driving device, the second sliding rail is installed on the installation surface, the second sliding rail is parallel to the first sliding rail and is arranged right below the first sliding rail, the second sliding block is slidably installed on the second sliding rail, the second clamping jaw is installed on the second sliding block, and the second driving device is arranged on the vertical support and is in transmission connection with the second sliding block;
The heating device is arranged on the mounting surface and positioned between the first sliding rail and the second sliding rail, a heating hole for the glass tube to pass through is formed in the heating device, and a heater is arranged in the heating hole;
The broken needle device is arranged on the mounting surface and is positioned between the heating device and the second sliding rail, and the broken needle device is used for cutting a glass tube positioned between the heating device and the second clamping jaw.
Optionally, the needle breaking device comprises a third sliding rail, a third sliding block, a connecting arm, a cutting edge and a third driving device, wherein the third sliding rail is installed on the installation surface, the third sliding rail is arranged along the horizontal direction and is parallel to the installation surface, the third sliding block is slidably installed on the third sliding rail, one end of the connecting arm is connected with the third sliding block, the cutting edge is connected with the third sliding block through the connecting arm, the third driving device is connected with the third sliding rail, and the third driving device is in transmission connection with the third sliding rail.
Optionally, the third slider is last to have dodge reset assembly, dodge reset assembly includes telescopic link and reset seat, the telescopic link with reset seat is along perpendicular to the direction interval arrangement of installation face, the telescopic link is located reset seat with between the installation face, the telescopic link perpendicular to the installation face, slidable wears to be equipped with the reset lever on the reset seat, the reset link with the telescopic link is coaxial, the one end of reset link is located reset seat with between the telescopic link, the other end of reset link is located reset seat is facing away from one side of installation face, the cover is equipped with the spring on the reset link, the one end of spring with the other end of reset link, the other end of spring with reset seat is connected, the middle part of linking arm through the pivot with the third slider rotates to be connected, the pivot is arranged along vertical direction, the one end of linking arm stretches into the telescopic link with between the reset seat, the telescopic link with the one end of reset link is located reset seat dorsad one side of linking arm respectively by the linking arm with the butt.
Optionally, the cutting edge is detachably connected with the connecting arm.
Optionally, the cutting edge is a tungsten steel blade in a disc shape.
Optionally, the first driving device, the second driving device and the third driving device are servo motors.
Optionally, the heater is a platinum iridium alloy ring, and the platinum iridium alloy ring is arranged around the hole wall of the heating hole.
Optionally, the automated micro-needle draw instrument further comprises a tube holder mounted on the first slider above the first jaw.
Optionally, the automatic micromanipulation needle drawing instrument further comprises an outer box body, the vertical support, the first clamping assembly, the second clamping assembly, the heating device and the needle breaking device are all installed in the inner portion of the outer box body, and the outer box body is provided with a transparent window capable of being opened and closed.
In a second aspect, an embodiment of the present invention provides a drawing method implemented based on the automatic micromanipulation needle drawing apparatus described in the first aspect, including:
Feeding a glass tube to be drawn, clamping the middle part of the glass tube by using the first clamping jaw, driving the first sliding block to slide on the first sliding rail by using the first driving device, enabling the glass tube to pass through the heating hole, and clamping the lower end of the glass tube by using the second clamping jaw;
Starting the heater, heating the glass tube by using the heating device, and stopping heating after the set heating time is reached;
Driving the second sliding block to slide on the second sliding rail by using the second driving device, and drawing the glass tube;
cutting the glass tube by using the needle breaking device to break the glass tube;
and driving the first sliding block to return to the initial position by using the first driving device, and loosening the first clamping jaw to finish drawing of the micro-operation needle.
The technical scheme provided by the embodiment of the invention has the beneficial effects that at least:
The automatic limiting operating needle drawing instrument provided by the embodiment of the invention is used for preparing the micro-operating needle, clamps the glass tube in the vertical direction through the first clamping jaw and the second clamping jaw with adjustable spacing, and draws the glass tube at a specified distance under the driving of the first driving device and the second driving device which are matched, so that the problem that the drawing length and the tube diameter of the glass tube cannot be accurately controlled due to dimensional deviation caused by manual operation is avoided. Meanwhile, in the heating process before stretching, the heating holes are adopted to perform 360-degree surrounding heating on the to-be-drawn section of the glass tube in the radial direction, so that the to-be-drawn section is heated uniformly, and the interference of the external environment on the heating process is reduced. The automatic drawing of the micro-operation needle in the laboratory in a flow manner is realized, the preparation precision is improved, and the rejection rate is reduced.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic elevational view of an automatic micromanipulation needle draw gauge provided in an embodiment of the present invention;
FIG. 2 is a left side structural plan view of an automatic micro-needle drawing machine provided in an embodiment of the present invention;
FIG. 3 is a top structural bottom view of an automatic micro-needle drawing instrument provided by an embodiment of the present invention;
FIG. 4 is a schematic top view of a heating device according to an embodiment of the present invention;
fig. 5 is a schematic perspective view of a needle breaking device according to an embodiment of the present invention;
fig. 6 is a schematic top view of a broken needle device according to an embodiment of the present invention;
fig. 7 is a schematic front view of a needle breaking device according to an embodiment of the present invention;
fig. 8 is a schematic right-view structural diagram of a needle breaking device according to an embodiment of the present invention;
fig. 9 is a schematic structural view of an outer case according to an embodiment of the present invention;
FIG. 10 is a block diagram of the control architecture of an automatic micro-needle draw machine provided by an embodiment of the present invention;
fig. 11 is a flowchart of a drawing method provided in an embodiment of the present invention.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the present invention more apparent, the embodiments of the present invention will be described in further detail with reference to the accompanying drawings.
In the related art, when a tester performs a drawing operation on a micro-needle, two clamping devices with adjustable intervals are generally used to clamp both ends of a glass tube as a raw material. And then the glass tube is fired and heated by using an alcohol lamp or a liquefied gas igniter, the glass tube is drawn into different lengths and tube diameters by manually adjusting the interval of the clamping devices, and finally the glass tube is cut by using a medical grinding wheel to form a fracture, so that the usable micro-operation needle is obtained.
The glass tube is heated by adopting open flame equipment such as an alcohol lamp or a liquefied gas igniter, and the like, the temperature in the combustion process is easily affected by the external environment to cause uneven heating, and the laboratory environment is easily polluted. Meanwhile, manual stretching firing is performed by manual operation, so that the dimension deviation is easy to cause, the stretching length and the pipe diameter of the glass pipe cannot be accurately controlled, the preparation precision of the micro-operation needle is low, and the rejection rate of materials is high.
Fig. 1 is a schematic front view of an automatic micro-needle drawing machine according to an embodiment of the present application. Fig. 2 is a left side structural plan view of an automatic micro-needle drawing machine provided in an embodiment of the present application. Fig. 3 is a top view of an automated micro-needle drawing instrument according to an embodiment of the present application. Fig. 4 is a schematic top view of a heating device according to an embodiment of the present application. Fig. 5 is a schematic perspective view of a needle breaking device according to an embodiment of the present application. Fig. 6 is a schematic top view of a broken needle device according to an embodiment of the present application. Fig. 7 is a schematic front view of a needle breaking device according to an embodiment of the present application. Fig. 8 is a schematic right-view structural diagram of a needle breaking device according to an embodiment of the present application. Fig. 9 is a schematic structural view of an outer case according to an embodiment of the present application. Fig. 10 is a block diagram of a control structure of an automatic micro-needle drawing machine according to an embodiment of the present application. As shown in fig. 1 to 10, through practice, the present inventors have provided an automatic micro-operation needle drawing apparatus including a vertical support 1, a first clamping assembly 2, a second clamping assembly 3, a heating device 4, a needle breaking device 5, and a controller 6, the first clamping assembly 2, the second clamping assembly 3, the heating device 4, and the needle breaking device 5 being electrically connected to the controller 6.
The vertical stand 1 has a mounting surface 11.
The first clamping assembly 2 comprises a first slide rail 21, a first slider 22, a first clamping jaw 23 and a first driving device 24. The first slide rail 21 is mounted on the mounting surface 11, and the first slide rail 21 is arranged in the vertical direction. The first slide block 22 is slidably mounted on the first slide rail 21, the first clamping jaw 23 is mounted on the first slide block 22, and the first driving device 24 is arranged on the vertical support 1 and is in transmission connection with the first slide block 22.
The second clamping assembly 3 comprises a second slide rail 31, a second slider 32, a second clamping jaw 33 and a second driving device 34. The second slide rail 31 is mounted on the mounting surface 11, and the second slide rail 31 is parallel to the first slide rail 21 and is disposed directly under the first slide rail 21. The second sliding block 32 is slidably mounted on the second sliding rail 31, the second clamping jaw 33 is mounted on the second sliding block 32, and the second driving device 34 is arranged on the vertical bracket 1 and is in transmission connection with the second sliding block 32.
The heating device 4 is mounted on the mounting surface 11 and is located between the first slide rail 21 and the second slide rail 31, a heating hole 41 through which the glass tube m passes is formed in the heating device 4, and a heater 42 is disposed in the heating hole 41.
The breaking device 5 is mounted on the mounting surface 11 and located between the heating device 4 and the second slide rail 31, the breaking device 5 being used for cutting the glass tube m located between the heating device 4 and the second jaw 33.
In the implementation of the invention, the controller 6 can receive the control instruction of an external computer or execute the control instruction preset in the controller to control and operate each part of the automatic micro-operation needle drawing instrument. When the micro-operation needle needs to be prepared, a tester can take the glass tube m to be drawn for feeding. After the glass tube m is aligned with the heating hole 41 on the heating device 4, the middle part of the glass tube m is clamped by the first clamping jaw 23, the first sliding block 22 is driven by the first driving device 24 to descend on the first sliding rail 21, the glass tube m is driven to pass through the heating hole 41 until the lower end of the glass tube m slides to the position of the second clamping jaw 33 to stop, and then the bottom of the glass tube m is clamped by the second clamping jaw 33, so that the clamping of the glass tube m is completed. Then, the heater 42 in the heating device 4 is started to heat the drawn section of the glass tube m positioned inside the heating hole 41, and the heating is stopped after the set heating time is reached. Then, the second slider 32 is driven by the second driving means 34 to descend to a set position on the second slide rail 31, and the heated glass tube m is elongated to a specified length. Finally, the glass tube m is broken by cutting the drawn section of the glass tube m between the heating device 4 and the second slide rail 31 by the breaking needle device 5. The first driving device 24 is used for driving the first sliding block 22 to ascend and return to the initial position, after the first clamping jaw 23 is loosened, a tester can take down the elongated and cut glass tube m clamped by the first clamping jaw 23, and the preparation of the micro-operation needle is completed.
The automatic limiting operating needle drawing instrument provided by the embodiment of the invention is used for preparing the micro-operating needle, clamps the glass tube m in the vertical direction through the first clamping jaw 23 and the second clamping jaw 33 with adjustable spacing, and draws the glass tube m at a specified distance under the driving of the first driving device 24 and the second driving device 34 which are matched with the first clamping jaw, so that the problem that the drawing length and the tube diameter of the glass tube cannot be accurately controlled due to dimensional deviation caused by manual operation is avoided. Meanwhile, in the heating process before stretching, the heating holes 41 are adopted to perform 360-degree surrounding heating on the section to be drawn of the glass tube m in the radial direction, so that the section to be drawn is heated uniformly, and the interference of the external environment on the heating process is reduced. The automatic drawing of the micro-operation needle in the laboratory in a flow manner is realized, the preparation precision is improved, and the rejection rate is reduced.
Optionally, the needle breaking device 5 includes a third sliding rail 51, a third slider 52, a connecting arm 53, a cutting edge 54 and a third driving device 55, the third sliding rail 51 is mounted on the mounting surface 11, the third sliding rail 51 is arranged along a horizontal direction and is parallel to the mounting surface 11, the third slider 52 is slidably mounted on the third sliding rail 51, one end of the connecting arm 53 is connected with the third slider 52, the cutting edge 54 is connected with the third slider 52 through the connecting arm 53, the third driving device 55 is connected with the third sliding rail 51, and the third driving device 55 is in transmission connection with the third sliding rail 51. Illustratively, in the embodiment of the invention, the breaking device 5 is located entirely between the heating device 4 and the second slide rail 31 in the vertical direction. When the glass tube m is fed, heated and drawn, the third slider 52 is positioned at the end of the third slide rail 51 farthest from the heating device 4 and the second slide rail 31. The cutting edge 54 is still spaced from the clamped glass tube m. After the heating and drawing are finished, the third driving device 55 can be used for driving the third sliding block 52 to slide towards one end close to the heating device 4 and the second sliding rail 31, so as to drive the connecting arm 53 and the cutting blade 54 positioned on the connecting arm 53 to move towards the glass tube m, the cutting blade 54 cuts the glass tube after contacting the glass tube m, and the glass tube m is cut off and then slides back to the initial position along with the third sliding block 52 again, so that a feeding space is reserved for next preparation.
Optionally, the third slider 52 is provided with the avoidance reset assembly 56, the avoidance reset assembly 56 includes a telescopic rod 561 and a reset seat 562, the telescopic rod 561 and the reset seat 562 are arranged at intervals along the direction perpendicular to the mounting surface 11, the telescopic rod 561 is located between the reset seat 562 and the mounting surface 11, the telescopic rod 561 is perpendicular to the mounting surface 11, the telescopic rod 563 is slidably arranged on the reset seat 562 in a penetrating manner, the telescopic rod 563 is coaxial with the telescopic rod 561, one end of the telescopic rod 563 is located between the reset seat 562 and the telescopic rod 561, the other end of the telescopic rod 563 is located at one side of the reset seat 562 opposite to the mounting surface 11, a spring 564 is sleeved on the telescopic rod 563, one end of the spring 564 is connected with the other end of the telescopic rod 563, the other end of the spring 564 is connected with the reset seat 562, the middle part of the connecting arm 53 is rotationally connected with the third slider 52 through a rotating shaft 565, one end of the connecting arm 53 extends into the telescopic rod 561 and the reset seat 562, and one ends of the telescopic rod 563 are respectively abutted by two sides of the connecting arm 53 and the connecting arm 53. Illustratively, in the embodiment of the present invention, when the third driving device 55 drives the third slider 52 to slide toward the end close to the heating device 4 and the second slide rail 31, the telescopic rod 561 is synchronously extended to push the end of the connecting arm 53 in contact with the same, so that the connecting arm 53 rotates around the rotation shaft 565, and the other end of the connecting arm 53 connected with the cutting blade 54 is close to the mounting surface 11. At this time, the telescopic rod 561 continuously provides the pushing force, and the return rod 563 correspondingly pushes out the side of the return seat 562 facing away from the mounting surface 11 and stretches the spring 564. After the third slider 52 is slid into place, the cutting edge 54 does not directly contact the glass tube m due to the rotational yielding of the connecting arm 53. At this time, the telescopic link 561 is controlled to shorten and reset, and the reset link 563 will return the connecting arm 53 to the top under the action of the spring force. At this time, the cutting blade 54 at the other end of the connecting arm 53 rotates towards the glass tube m, and breaks the cutting part of the glass tube m under the action of inertia while contacting and cutting the glass tube m, so that the stable separation of the cutting part is ensured, the situation that the cutting is not in place is avoided, and the preparation precision is further improved.
Optionally, the cutting edge 54 is detachably connected to the connecting arm 53. Illustratively, in embodiments of the present invention, the cutting edge 54 may be removed from the connecting arm 53 for maintenance and replacement after extended use, improving the overall useful life of the automatic limit operation pin drawing instrument.
Alternatively, the cutting edge 54 is a tungsten steel blade having a disk shape. Illustratively, in the embodiment of the invention, the tungsten steel is prepared by pressing and sintering high-quality tungsten carbide and cobalt powder after being mixed according to the formula ratio, and has high hardness, high strength, high wear resistance and high elastic modulus. And meanwhile, the disc-shaped cutting edge 54 is adopted, after a part of the cutting edge is worn, other unused cutting edges can be set to the cutting position for repeated use through rotation, so that the overall service life of the automatic limit operation needle drawing instrument is further prolonged.
Optionally, the first drive 24, the second drive 34 and the third drive 55 are servomotors. The response time difference is smaller than 50ms after the control command is received, the control precision is high, the clamping force and the driving stroke in the drawing process can be accurately controlled, and the preparation precision is ensured.
Alternatively, the heater 42 is a platinum iridium alloy ring, and a platinum iridium alloy ring is disposed around the wall of the heating hole 41. Illustratively, in the embodiment of the present invention, after heating, the platinum-iridium alloy ring, that is, the temperature in the heating hole 41, may be instantaneously heated to 800 ℃ to 900 ℃ by loading a large current to both ends of the platinum-iridium alloy ring, so that the heating speed is fast, and the preparation precision requirement is effectively ensured. Meanwhile, compared with the method for heating the glass tube by adopting open flame equipment such as an alcohol lamp or a liquefied gas igniter, the method has the advantage that the environment in a laboratory is not polluted.
Optionally, the automated micro-needle drawing instrument further comprises a tube rest 25, the tube rest 25 being mounted on the first slider 22 above the first jaw 23. In the embodiment of the invention, before loading and clamping the glass tube m, the glass tube m can be put into the mounting hole on the pipe support 25 to pass through, the mounting hole of the pipe support 25 faces the first clamping jaw 23 and the second clamping jaw 33, and the glass tube m can accurately slide to the clamping positions of the first clamping jaw 23 and the second clamping jaw 33 by using the limiting guide of the pipe support 25, so that the clamping and fastening are in place, the coaxial and non-bending state is always kept during drawing, and the preparation precision is further improved.
Optionally, the automatic micromanipulation needle drawing instrument further comprises an outer box 7, a vertical bracket 1, a first clamping assembly 2, a second clamping assembly 3, a heating device 4 and a needle breaking device 5 are all installed inside the outer box 7, and a openable transparent window 71 is formed in the outer box 7. Illustratively, in the embodiment of the present invention, during the drawing process of the limiting operation needle, after the loading and clamping are completed, the transparent window 71 may be closed to observe the drawing process from the outside, and after the completion, the transparent window is opened again to perform loading and unloading. Further ensuring that the process of heating and drawing the glass tube m is not influenced by the external environment and the temperature, and further improving the preparation precision.
Fig. 11 is a flowchart of a drawing method provided in an embodiment of the present invention. As shown in fig. 11, the embodiment of the present invention further provides a drawing method, which is implemented based on the automatic micro-needle drawing apparatus described in fig. 1 to 10, and includes the following steps:
S1, feeding a glass tube m to be drawn, clamping the middle part of the glass tube m by using a first clamping jaw 23, driving a first sliding block 22 to slide on a first sliding rail 21 by using a first driving device 24, enabling the glass tube m to pass through a heating hole 41, and clamping the lower end of the glass tube m by using a second clamping jaw 33.
Specifically, when the micro-operation needle needs to be prepared, a tester can take the glass tube m to be drawn for feeding. After the glass tube m is aligned with the heating hole 41 on the heating device 4, the middle part of the glass tube m is clamped by the first clamping jaw 23, the first sliding block 22 is driven by the first driving device 24 to descend on the first sliding rail 21, the glass tube m is driven to pass through the heating hole 41 until the lower end of the glass tube m slides to the position of the second clamping jaw 33 to stop, and then the bottom of the glass tube m is clamped by the second clamping jaw 33, so that the clamping of the glass tube m is completed.
S2, starting the heater 42, heating the glass tube m by the heating device 4, and stopping heating after the set heating time is reached.
And S3, driving the second sliding block 32 to slide on the second sliding rail 31 by using the second driving device 34, and drawing the glass tube m.
Specifically, the second slider 32 is driven by the second driving means 34 to descend to a set position on the second slide rail 31, and the heated glass tube m is elongated to a specified length.
S4, cutting the glass tube by using the needle breaking device 5 to break the glass tube m.
S5, the first driving device 24 is used for driving the first sliding block 22 to return to the initial position, the first clamping jaw 23 is loosened, and drawing of the micro-operation needle is completed.
Specifically, the first driving device 24 is used for driving the first sliding block 22 to ascend and return to the initial position, after the first clamping jaw 23 is loosened, a tester can take down the elongated and cut glass tube m clamped by the first clamping jaw 23, and the preparation of the micro-operation needle is completed.
The automatic limiting operating needle drawing instrument and the drawing method provided by the embodiment of the invention are adopted to prepare the micro-operating needle, the glass tube m is clamped in the vertical direction by the first clamping jaw 23 and the second clamping jaw 33 with adjustable spacing, and the glass tube m is drawn for a specified distance under the driving of the first driving device 24 and the second driving device 34 which are matched, so that the problem that the drawing length and the tube diameter of the glass tube cannot be accurately controlled due to dimensional deviation caused by manual operation is avoided. Meanwhile, in the heating process before stretching, the heating holes 41 are adopted to perform 360-degree surrounding heating on the section to be drawn of the glass tube m in the radial direction, so that the section to be drawn is heated uniformly, and the interference of the external environment on the heating process is reduced. The automatic drawing of the micro-operation needle in the laboratory in a flow manner is realized, the preparation precision is improved, and the rejection rate is reduced.
Unless defined otherwise, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this invention belongs. The terms "first," "second," and the like in the description and in the claims, are not used for any order, quantity, or importance, but are used for distinguishing between different elements. Likewise, the terms "a" or "an" and the like do not denote a limitation of quantity, but rather denote the presence of at least one. The word "comprising" or "comprises", and the like, means that elements or items appearing before "comprising" or "comprising" are intended to be inclusive of the elements or items listed thereafter as "comprising" or "comprising", and not to exclude other elements or items. The terms "connected" or "connected," and the like, are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "upper", "lower", "left", "right", etc. are used merely to denote relative positional relationships, which may also change accordingly when the absolute position of the object to be described changes.
The foregoing description of the preferred embodiments of the present invention is not intended to limit the invention, but rather, the invention is to be construed as limited to the appended claims.
Claims (8)
1. An automatic micromachined pin drawing instrument, comprising: the vertical bracket (1), a first clamping component (2), a second clamping component (3), a heating device (4), a needle breaking device (5) and a controller (6), wherein the first clamping component (2), the second clamping component (3), the heating device (4) and the needle breaking device (5) are electrically connected with the controller (6),
The vertical bracket (1) is provided with a mounting surface (11);
The first clamping assembly (2) comprises a first sliding rail (21), a first sliding block (22), a first clamping jaw (23) and a first driving device (24), wherein the first sliding rail (21) is installed on the installation surface (11), the first sliding rail (21) is arranged along the vertical direction, the first sliding block (22) is slidably installed on the first sliding rail (21), the first clamping jaw (23) is installed on the first sliding block (22), and the first driving device (24) is arranged on the vertical support (1) and is in transmission connection with the first sliding block (22);
The second clamping assembly (3) comprises a second sliding rail (31), a second sliding block (32), a second clamping jaw (33) and a second driving device (34), the second sliding rail (31) is installed on the installation surface (11), the second sliding rail (31) is parallel to the first sliding rail (21) and is arranged under the first sliding rail (21), the second sliding block (32) is slidably installed on the second sliding rail (31), the second clamping jaw (33) is installed on the second sliding block (32), and the second driving device (34) is arranged on the vertical support (1) and is in transmission connection with the second sliding block (32);
the heating device (4) is arranged on the mounting surface (11) and positioned between the first sliding rail (21) and the second sliding rail (31), a heating hole (41) for a glass tube (m) to pass through is formed in the heating device (4), and a heater (42) is arranged in the heating hole (41);
The needle breaking device (5) is arranged on the mounting surface (11) and is positioned between the heating device (4) and the second sliding rail (31), the needle breaking device (5) is used for cutting a glass tube (m) positioned between the heating device (4) and the second clamping jaw (33), the needle breaking device (5) comprises a third sliding rail (51), a third sliding block (52), a connecting arm (53), a cutting blade (54) and a third driving device (55), the third sliding rail (51) is arranged on the mounting surface (11), the third sliding rail (51) is arranged along the horizontal direction and is parallel to the mounting surface (11), the third sliding block (52) is slidably arranged on the third sliding rail (51), one end of the connecting arm (53) is connected with the third sliding block (52), the cutting blade (54) is connected with the third sliding block (52) through the connecting arm (53), the third driving device (55) is connected with the third sliding rail (51) in a horizontal direction and is parallel to the third sliding rail (562) and is provided with a reset assembly (561), the telescopic rod (561) and the reset seat (562) are arranged at intervals along the direction perpendicular to the installation surface (11), the telescopic rod (561) is positioned between the reset seat (562) and the installation surface (11), the telescopic rod (561) is perpendicular to the installation surface (11), the reset rod (563) is slidably arranged on the reset seat (562) in a penetrating way, the reset rod (563) is coaxial with the telescopic rod (561), one end of the reset rod (563) is positioned between the reset seat (562) and the telescopic rod (561), the other end of the reset rod (563) is positioned at one side, opposite to the installation surface (11), of the reset seat (562), a spring (564) is sleeved on the reset rod (563), one end of the spring (564) is connected with the other end of the reset rod (563), the other end of the spring (564) is connected with the reset seat (562), the middle part of the connecting arm (53) is connected with the first rotating shaft (565) through a sliding block (565) in the vertical direction, the connecting arm (565) is connected with the rotating shaft (52) along the direction of the rotating shaft (53), one ends of the telescopic rod (561) and the reset rod (563) are respectively abutted with the connecting arm (53) through two sides of the connecting arm (53).
2. The automatic micro-needle drawing instrument according to claim 1, wherein the cutting edge (54) is detachably connected to the connecting arm (53).
3. The automatic micro-needle drawing machine according to claim 2, wherein the cutting edge (54) is a tungsten steel blade in the shape of a disk.
4. The automatic micro-needle drawing instrument according to claim 1, wherein the first driving means (24), the second driving means (34) and the third driving means (55) are servo motors.
5. The automatic micromanipulation needle drawing instrument according to claim 1, wherein said heater (42) is a platinum iridium alloy ring, said platinum iridium alloy being disposed around a wall of said heating aperture (41).
6. The automatic micro-needle drawing instrument according to claim 1, further comprising a pipe bracket (25), the pipe bracket (25) being mounted on the first slider (22) above the first clamping jaw (23).
7. The automatic micro-needle drawing instrument according to claim 1, further comprising an outer box (7), wherein the vertical support (1), the first clamping assembly (2), the second clamping assembly (3), the heating device (4) and the needle breaking device (5) are all installed inside the outer box (7), and a transparent window (71) capable of being opened and closed is formed on the outer box (7).
8. A drawing method of a cover slip, the drawing method being implemented based on the automatic micromanipulation needle drawing instrument according to any one of claims 1 to 7, characterized in that the drawing method comprises:
Feeding a glass tube (m) to be drawn, clamping the middle part of the glass tube (m) by using the first clamping jaw (23), driving the first sliding block (22) to slide on the first sliding rail (21) by using the first driving device (24), enabling the glass tube (m) to pass through the heating hole (41), and clamping the lower end of the glass tube (m) by using the second clamping jaw (33);
starting the heater (42), heating the glass tube (m) by the heating device (4), and stopping heating after the set heating time is reached;
Driving the second slider (32) to slide on the second slide rail (31) by using the second driving device (34) so as to draw the glass tube (m);
Cutting the glass tube (m) by the needle breaking device (5) to break the glass tube (m);
The first sliding block (22) is driven to return to the initial position by the first driving device (24), the first clamping jaw (23) is loosened, and the drawing of the micro-operation needle is completed.
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| CN202211310602.8A CN115583788B (en) | 2022-10-25 | 2022-10-25 | Automatic micromanipulation needle drawing instrument and drawing method |
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| CN202211310602.8A CN115583788B (en) | 2022-10-25 | 2022-10-25 | Automatic micromanipulation needle drawing instrument and drawing method |
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| CN115583788B true CN115583788B (en) | 2024-04-26 |
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| CN117003482B (en) * | 2023-10-08 | 2023-12-19 | 成都泰盟软件有限公司 | Vertical drawing instrument for multi-step drawing |
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| CN102453667A (en) * | 2010-10-26 | 2012-05-16 | 陈浩杰 | Microscope fixing pin manufacturing method and microscope fixing pin manufactured by same |
| CN202945150U (en) * | 2012-10-19 | 2013-05-22 | 云南大学 | Glass capillary needle drawing device |
| CN106865962A (en) * | 2017-04-08 | 2017-06-20 | 贵州大学 | It is a kind of to integrate micro-nano nozzle drawing forging instrument apparatus and the method drawn with forging |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102453667A (en) * | 2010-10-26 | 2012-05-16 | 陈浩杰 | Microscope fixing pin manufacturing method and microscope fixing pin manufactured by same |
| CN202945150U (en) * | 2012-10-19 | 2013-05-22 | 云南大学 | Glass capillary needle drawing device |
| CN106865962A (en) * | 2017-04-08 | 2017-06-20 | 贵州大学 | It is a kind of to integrate micro-nano nozzle drawing forging instrument apparatus and the method drawn with forging |
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| CN115583788A (en) | 2023-01-10 |
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