CN115572572A - Medical UV adhesive for peripherally placing central venous catheter and preparation method thereof - Google Patents
Medical UV adhesive for peripherally placing central venous catheter and preparation method thereof Download PDFInfo
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- CN115572572A CN115572572A CN202211215846.8A CN202211215846A CN115572572A CN 115572572 A CN115572572 A CN 115572572A CN 202211215846 A CN202211215846 A CN 202211215846A CN 115572572 A CN115572572 A CN 115572572A
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- 239000000853 adhesive Substances 0.000 title claims description 21
- 230000001070 adhesive effect Effects 0.000 title claims description 21
- 238000002360 preparation method Methods 0.000 title abstract description 10
- 239000003292 glue Substances 0.000 claims abstract description 25
- 239000000178 monomer Substances 0.000 claims abstract description 22
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 21
- 239000003085 diluting agent Substances 0.000 claims abstract description 21
- 229920002635 polyurethane Polymers 0.000 claims abstract description 20
- 239000004814 polyurethane Substances 0.000 claims abstract description 20
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims abstract description 19
- 239000003999 initiator Substances 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000003756 stirring Methods 0.000 claims abstract description 9
- 229920003232 aliphatic polyester Polymers 0.000 claims description 8
- FIHBHSQYSYVZQE-UHFFFAOYSA-N 6-prop-2-enoyloxyhexyl prop-2-enoate Chemical compound C=CC(=O)OCCCCCCOC(=O)C=C FIHBHSQYSYVZQE-UHFFFAOYSA-N 0.000 claims description 6
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 6
- DAKWPKUUDNSNPN-UHFFFAOYSA-N Trimethylolpropane triacrylate Chemical compound C=CC(=O)OCC(CC)(COC(=O)C=C)COC(=O)C=C DAKWPKUUDNSNPN-UHFFFAOYSA-N 0.000 claims description 6
- -1 acrylic ester Chemical class 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 4
- GNWBLLYJQXKPIP-ZOGIJGBBSA-N (1s,3as,3bs,5ar,9ar,9bs,11as)-n,n-diethyl-6,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,5a,8,9,9b,10,11-dodecahydro-1h-indeno[5,4-f]quinoline-1-carboxamide Chemical compound CN([C@@H]1CC2)C(=O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)N(CC)CC)[C@@]2(C)CC1 GNWBLLYJQXKPIP-ZOGIJGBBSA-N 0.000 claims description 3
- PSGCQDPCAWOCSH-UHFFFAOYSA-N (4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl) prop-2-enoate Chemical compound C1CC2(C)C(OC(=O)C=C)CC1C2(C)C PSGCQDPCAWOCSH-UHFFFAOYSA-N 0.000 claims description 3
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims description 3
- ZDQNWDNMNKSMHI-UHFFFAOYSA-N 1-[2-(2-prop-2-enoyloxypropoxy)propoxy]propan-2-yl prop-2-enoate Chemical compound C=CC(=O)OC(C)COC(C)COCC(C)OC(=O)C=C ZDQNWDNMNKSMHI-UHFFFAOYSA-N 0.000 claims description 3
- VHSHLMUCYSAUQU-UHFFFAOYSA-N 2-hydroxypropyl methacrylate Chemical compound CC(O)COC(=O)C(C)=C VHSHLMUCYSAUQU-UHFFFAOYSA-N 0.000 claims description 3
- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 claims description 3
- WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 claims description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 3
- NDWUBGAGUCISDV-UHFFFAOYSA-N 4-hydroxybutyl prop-2-enoate Chemical compound OCCCCOC(=O)C=C NDWUBGAGUCISDV-UHFFFAOYSA-N 0.000 claims description 3
- 102100026735 Coagulation factor VIII Human genes 0.000 claims description 3
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims description 3
- IAXXETNIOYFMLW-COPLHBTASA-N [(1s,3s,4s)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl] 2-methylprop-2-enoate Chemical compound C1C[C@]2(C)[C@@H](OC(=O)C(=C)C)C[C@H]1C2(C)C IAXXETNIOYFMLW-COPLHBTASA-N 0.000 claims description 3
- VFHVQBAGLAREND-UHFFFAOYSA-N diphenylphosphoryl-(2,4,6-trimethylphenyl)methanone Chemical compound CC1=CC(C)=CC(C)=C1C(=O)P(=O)(C=1C=CC=CC=1)C1=CC=CC=C1 VFHVQBAGLAREND-UHFFFAOYSA-N 0.000 claims description 3
- 229940119545 isobornyl methacrylate Drugs 0.000 claims description 3
- ZDHCZVWCTKTBRY-UHFFFAOYSA-N omega-Hydroxydodecanoic acid Natural products OCCCCCCCCCCCC(O)=O ZDHCZVWCTKTBRY-UHFFFAOYSA-N 0.000 claims description 3
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 claims description 3
- 239000012956 1-hydroxycyclohexylphenyl-ketone Substances 0.000 claims description 2
- MQDJYUACMFCOFT-UHFFFAOYSA-N bis[2-(1-hydroxycyclohexyl)phenyl]methanone Chemical compound C=1C=CC=C(C(=O)C=2C(=CC=CC=2)C2(O)CCCCC2)C=1C1(O)CCCCC1 MQDJYUACMFCOFT-UHFFFAOYSA-N 0.000 claims description 2
- JRWNODXPDGNUPO-UHFFFAOYSA-N oxolane;prop-2-enoic acid Chemical compound C1CCOC1.OC(=O)C=C JRWNODXPDGNUPO-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- 239000004721 Polyphenylene oxide Substances 0.000 description 5
- 239000002313 adhesive film Substances 0.000 description 5
- 229920000570 polyether Polymers 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000032683 aging Effects 0.000 description 4
- 239000012948 isocyanate Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000009864 tensile test Methods 0.000 description 4
- 125000001931 aliphatic group Chemical group 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- UHESRSKEBRADOO-UHFFFAOYSA-N ethyl carbamate;prop-2-enoic acid Chemical compound OC(=O)C=C.CCOC(N)=O UHESRSKEBRADOO-UHFFFAOYSA-N 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 238000002791 soaking Methods 0.000 description 3
- 230000007547 defect Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000004383 yellowing Methods 0.000 description 2
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 1
- 206010070835 Skin sensitisation Diseases 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- MUTNCGKQJGXKEM-UHFFFAOYSA-N tamibarotene Chemical compound C=1C=C2C(C)(C)CCC(C)(C)C2=CC=1NC(=O)C1=CC=C(C(O)=O)C=C1 MUTNCGKQJGXKEM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J175/00—Adhesives based on polyureas or polyurethanes; Adhesives based on derivatives of such polymers
- C09J175/04—Polyurethanes
- C09J175/14—Polyurethanes having carbon-to-carbon unsaturated bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a medical UV glue with a central venous catheter placed in the periphery and a preparation method thereof, wherein the components in parts by weight comprise 30-40 parts of polyurethane acrylate, 40-50 parts of reactive diluent monomer, 4-8 parts of cross-linking agent monomer and 2-5 parts of initiator, the polyurethane acrylate, the reactive diluent and the cross-linking agent are weighed in proportion and added into a beaker during preparation, then the beaker is placed in a water bath and stirred for 10min at the temperature of 50 ℃, and the initiator is added for stirring until the mixture is completely dissolved.
Description
Technical Field
The invention relates to the field of medical adhesives, in particular to medical UV (ultraviolet) adhesive for peripherally placing a central venous catheter and a preparation method thereof.
Background
The central venous catheter, also called PICC, is placed peripherally. Due to the complexity of the catheter hub design, the catheter hub cannot be assembled with the catheter in an encapsulation mode, and only UV glue can be used for bonding. As the longest time for the product to stay in the human body is one year, the patient inevitably touches natural aging factors such as sunlight, water vapor and the like during free activity, the UV adhesive aging causes the bonding property to be poor, and the patient is in a dangerous state of infection once falling off.
After being cured, the commercially available medical UV adhesive is placed into hot water at 55 ℃ for soaking for 24 hours, and the adhesive film is found to be cracked by being slightly pinched by hands, namely the adhesive film has poor strength and water resistance and cannot meet the clinical use of products. Therefore, the development of a UV adhesive with excellent water resistance is urgently needed, and the situation that accessories of a patient cannot fall off in normal life is guaranteed.
Disclosure of Invention
The purpose of the invention is as follows: the invention aims to provide medical UV glue for peripherally placing a central venous catheter and a preparation method thereof aiming at the defects of the prior art.
The technical scheme is as follows: the medical UV adhesive comprises, by weight, 30-40 parts of polyurethane acrylate, 40-50 parts of a reactive diluent monomer, 4-8 parts of a cross-linking agent monomer and 2-5 parts of an initiator.
Preferably, the polyurethane acrylate is a difunctional aliphatic polyester with a molecular weight of 1500-2000 and a tensile strain of 300-400%.
Preferably, the reactive diluent monomer comprises one or more of isobornyl acrylate IBOA, isobornyl methacrylate IBOMA, hydroxyethyl methacrylate HEMA, 4-hydroxybutylacrylate 4-HBA, hydroxypropyl methacrylate HPMA, tetrahydrofurfuryl acrylate THFA, n.n. dimethylacrylamide DMAA.
Preferably, the cross-linking agent monomer comprises one or a combination of 1,6-hexanediol diacrylate HDDA, tripropylene glycol diacrylate TPGDA and trimethylolpropane triacrylate TMPTA.
Preferably, the initiator comprises 1-hydroxycyclohexylphenone, 2,4,6-trimethylbenzoyl-diphenylphosphine oxide.
A preparation method of medical UV glue peripherally inserted into a central venous catheter comprises the following steps:
s1, weighing polyurethane acrylate, a reactive diluent and a cross-linking agent according to a proportion, and adding the polyurethane acrylate, the reactive diluent and the cross-linking agent into a beaker;
s2, placing the beaker after the charging into a water bath, stirring for 10min at the temperature of 50 ℃, adding an initiator, and stirring until the initiator is completely dissolved, thereby obtaining the medical UV glue solution.
Compared with the prior art, the invention has the following beneficial effects: the UV adhesive adopts polyurethane acrylate, and the prepared medical UV adhesive has good bonding effect and water resistance effect by adjusting the proportion of the reactive diluent monomer, the cross-linking agent monomer and the photoinitiator, and simultaneously greatly prolongs the aging time and prolongs the service life.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "axial," "radial," "circumferential," and the like are used in an orientation or positional relationship indicated to facilitate describing the invention and to simplify the description, but do not indicate or imply that the device or element so referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be considered as limiting the invention.
In the present invention, unless otherwise specifically stated or limited, the terms "mounted," "connected," "fixed," and the like are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally formed; the connection can be mechanical connection, electrical connection or communication connection; either directly or indirectly through intervening media, either internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
The technical solution of the present invention will be described in detail below with specific examples. The following several specific embodiments may be combined with each other, and details of the same or similar concepts or processes may not be repeated in some embodiments.
The medical UV adhesive for peripherally placing a central venous catheter comprises, by weight, 30-40 parts of urethane acrylate, 40-50 parts of a reactive diluent monomer, 4-8 parts of a cross-linking agent monomer and 2-5 parts of an initiator.
Specifically, the polyurethane acrylate is difunctional aliphatic polyester, the molecular weight is 1500-2000, and the tensile strain is 300-400%; the reactive diluent monomer comprises one or more of isobornyl acrylate IBOA, isobornyl methacrylate IBOMA, hydroxyethyl methacrylate HEMA, 4-hydroxybutyl acrylate 4-HBA, hydroxypropyl methacrylate HPMA, tetrahydrofuran acrylate THFA, N.N. dimethylacrylamide DMAA; the cross-linking agent monomer comprises one or a combination of 1,6-hexanediol diacrylate HDDA, tripropylene glycol diacrylate TPGDA and trimethylolpropane triacrylate TMPTA; the initiator includes 1-hydroxycyclohexyl phenyl ketone, 2,4,6-trimethylbenzoyl-diphenylphosphine oxide.
The main body part of the UV glue is polyurethane acrylate, a reactive diluent, a cross-linking agent and a photoinitiator. The urethane acrylate is classified into aromatic polyether, aliphatic polyether, and aliphatic polyester according to the kind of isocyanate and the kind of polyol. The aromatic isocyanate has the characteristics of heat resistance, solvent resistance and obvious defect because the aromatic isocyanate contains benzene rings, and the internal benzene rings are easy to react with oxygen to form benzoquinone, so that yellowing is caused. Aliphatic isocyanate does not contain benzene rings, so that yellowing does not occur, but the solvent resistance is poor, and the hardness is relatively low. The polyether is characterized by high flexibility, but has strong hydrophilicity and low mechanical strength because of containing a large amount of ether bonds. The polyester is characterized by having a large number of ester bonds, strong hydrophobic property, easy formation of hydrogen bonds by the ester bonds, high cohesive strength of a molecular chain and high integral mechanical strength.
The PICC catheter material adopts TPU which is aliphatic polyester, and is characterized in that the catheter has high mechanical strength and can not be broken because of being kept in a human blood vessel for a long time.
Thus, based on the above analysis, the urethane acrylate in the UV glue is chosen to be of the aliphatic polyester type. The optimal bonding effect and water resistance effect are achieved by adjusting the proportion of the reactive diluent monomer, the cross-linking agent monomer and the photoinitiator.
The technical scheme has the advantages that the polyurethane acrylate is adopted in the UV adhesive, and the prepared medical UV adhesive has good bonding effect and water resistance effect by adjusting the proportion of the reactive diluent monomer, the cross-linking agent monomer and the photoinitiator, so that the aging time is greatly prolonged, and the service life is prolonged.
The preparation method comprises the following steps: s1, weighing polyurethane acrylate, a reactive diluent and a crosslinking agent according to a proportion, and adding the polyurethane acrylate, the reactive diluent and the crosslinking agent into a beaker;
s2, placing the beaker after the charging into a water bath, stirring for 10min at the temperature of 50 ℃, adding an initiator, and stirring until the initiator is completely dissolved, thereby obtaining the medical UV glue solution.
According to the components and the preparation method, in order to fully test the product performance and compare the technical progress, three groups of examples, namely example 1, example 2 and example 3 are designed, and three groups of comparative examples, namely comparative example 1, comparative example 2 and comparative example 3 are arranged. The polyurethane acrylate type in the example is difunctional aliphatic polyester, the molecular weight is 1500-2000, the tensile strain is 300-400%, the polyurethane acrylate type in the comparative example is difunctional aliphatic polyether, the molecular weight is 1500-2000, the tensile strain is 300-400%, and the proportion of the reactive diluent monomer, the cross-linking agent monomer and the photoinitiator is adjusted to carry out the test, and the preparation method comprises the following steps: s1, weighing polyurethane acrylate, a reactive diluent and a crosslinking agent according to a proportion, and adding the polyurethane acrylate, the reactive diluent and the crosslinking agent into a beaker; s2, placing the beaker after the material loading into a water bath and stirring for 10min at the temperature of 50 ℃, and then adding an initiator and stirring until the initiator is completely dissolved, thereby obtaining the medical UV glue solution; the ratio of the amounts of the respective components in example 1, example 2, example 3, comparative example 1, comparative example 2 and comparative example 3 is shown in the following table, for example.
The test items and methods were as follows:
1. adhesive force between adhesive film and conduit
And (3) coating the glue on the surface of the TPU conduit, wherein the glue is in a shape of 1 and has the length of 1cm, fixing the two ends of the conduit on a clamp of a tensile testing machine after ultraviolet curing, setting the speed at 20mm/s, and observing whether the glue film is separated after the glue film is stretched to 5cm along with the conduit.
2. Tear resistance of adhesive film
And (3) coating the glue on the surface of the TPU conduit, wherein the glue is in a shape of 1 and has the length of 1cm, fixing the two ends of the conduit to a clamp of a tensile testing machine after ultraviolet curing, setting the speed to be 20mm/s, and observing whether the glue film is broken after the glue film is stretched to 5cm along with the conduit.
3. Water-proof performance of glue film
And (3) coating glue on the surface of the TPU catheter, wherein the glue is in a shape of a Chinese character '1', the length of the TPU catheter is 1cm, soaking the TPU catheter in water at 55 ℃ for 12h after ultraviolet curing, fishing out and airing, fixing two ends of the TPU catheter in a tensile testing machine clamp at a speed set to be 20mm/s, and observing whether the glue film is separated or broken after the TPU catheter is stretched to 5cm along with the TPU catheter.
4. Product bonding strength
The PICC catheter holder and the connector UV glue are integrally placed into water at 55 ℃ for soaking for 12h after being bonded, the PICC catheter holder and the connector UV glue are fished out and aired, then two ends of the PICC catheter holder are fixed on a clamp of a tensile testing machine, the speed is set to be 20mm/s, and the damage condition of the bonded part is observed. The product was aged in an environment at 55 ℃ and 20% RH at an accelerated rate for 40 days, taken out, and the adhesive strength was measured to observe the failure of the adhesive part.
5. Biological assay
And carrying out intracutaneous stimulation and skin sensitization biological performance tests on the bonded product according to the standards of GB/T16886.5-2017 cytotoxicity and GB/T16886.10-2017.
The results obtained from testing the above test items are shown in the following table:
it can be seen from the comparison of examples 1, 2 and 3 that when TPGDA is not suitable for the UV adhesive bonding system, the adhesive film strength and water resistance of aliphatic polyester are better than those of aliphatic polyether in the comparative example, and the formulation of example 3 is biologically tested and passed to meet the medical requirements.
In the present invention, unless otherwise explicitly specified or limited, the first feature "on" or "under" the second feature may be directly contacting the first feature and the second feature or indirectly contacting the first feature and the second feature through an intermediate. Also, a first feature "on," "above," and "over" a second feature may mean that the first feature is directly above or obliquely above the second feature, or that only the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lower level than the second feature. In the description herein, reference to the description of the term "one embodiment," "some embodiments," "an example," "a specific example" or "some examples," or the like, means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example.
Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (6)
1. The utility model provides a medical UV glues of central venous catheter is put into through periphery which characterized in that: the components by weight portion include polyurethane acrylic ester 30-40 parts, reactive diluent monomer 40-50 parts, cross-linking agent monomer 4-8 parts, and initiator 2-5 parts.
2. The medical UV adhesive for peripherally inserted central venous catheters according to claim 1, wherein: the polyurethane acrylate is difunctional aliphatic polyester, the molecular weight is 1500-2000, and the tensile strain is 300-400%.
3. The medical UV adhesive for peripherally inserted central venous catheters according to claim 1, wherein: the reactive diluent monomer comprises one or a combination of isobornyl acrylate IBOA, isobornyl methacrylate IBOMA, hydroxyethyl methacrylate HEMA, 4-hydroxybutyl acrylate 4-HBA, hydroxypropyl methacrylate HPMA, tetrahydrofuran acrylate THFA, N.N. dimethylacrylamide DMAA.
4. The medical UV adhesive for peripherally inserted central venous catheters according to claim 1, wherein: the cross-linking agent monomer comprises one or a combination of 1,6-hexanediol diacrylate HDDA, tripropylene glycol diacrylate TPGDA and trimethylolpropane triacrylate TMPTA.
5. The medical UV adhesive for peripherally inserted central venous catheters according to claim 1, wherein: the initiator includes 1-hydroxycyclohexyl phenyl ketone, 2,4,6-trimethylbenzoyl-diphenylphosphine oxide.
6. The method for preparing the medical UV adhesive which is peripherally inserted into the central venous catheter according to the claims 1 to 5, is characterized in that: the method comprises the following steps:
s1, weighing polyurethane acrylate, a reactive diluent and a crosslinking agent according to a proportion, and adding the polyurethane acrylate, the reactive diluent and the crosslinking agent into a beaker;
s2, placing the beaker after the charging into a water bath, stirring for 10min at the temperature of 50 ℃, adding an initiator, and stirring until the initiator is completely dissolved, thereby obtaining the medical UV glue solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211215846.8A CN115572572A (en) | 2022-09-30 | 2022-09-30 | Medical UV adhesive for peripherally placing central venous catheter and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211215846.8A CN115572572A (en) | 2022-09-30 | 2022-09-30 | Medical UV adhesive for peripherally placing central venous catheter and preparation method thereof |
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| Publication Number | Publication Date |
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| CN115572572A true CN115572572A (en) | 2023-01-06 |
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| CN202211215846.8A Pending CN115572572A (en) | 2022-09-30 | 2022-09-30 | Medical UV adhesive for peripherally placing central venous catheter and preparation method thereof |
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| CN105820794A (en) * | 2016-05-30 | 2016-08-03 | 三友（天津）高分子技术有限公司 | Inorganic filler modified ultraviolet curing adhesive |
| CN106833497A (en) * | 2016-12-26 | 2017-06-13 | 深圳市易盛新材料科技有限公司 | A kind of UV glue and preparation method thereof |
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