CN115531045A

CN115531045A - Prosthesis structure

Info

Publication number: CN115531045A
Application number: CN202211202825.2A
Authority: CN
Inventors: 柴伟; 孔祥朋; 曹正; 杨敏之; 孟德松; 刘昆玺; 马小林
Original assignee: Beijing AK Medical Co Ltd; Fourth Medical Center General Hospital of Chinese PLA
Current assignee: Beijing AK Medical Co Ltd; Fourth Medical Center General Hospital of Chinese PLA
Priority date: 2022-09-29
Filing date: 2022-09-29
Publication date: 2022-12-30

Abstract

The present invention provides a prosthetic structure comprising: a base portion; a porous portion provided at one side of the base portion; a drug-carrying portion disposed within the base portion and/or the porous portion, the drug-carrying portion comprising: a drug output channel having an inlet end and an outlet end; the inner-layer medicine carrying bin is communicated with the medicine output channel and comprises an inner-layer main cavity arranged at the inlet end and an inner-layer expansion cavity which is arranged on the cavity wall of the inner-layer main cavity in a communicated manner and extends towards the direction far away from the medicine output channel; outer medicine carrying storehouse, with inlayer medicine carrying storehouse intercommunication, outer medicine carrying storehouse sets up on the chamber wall of outer main cavity and towards the outer extension chamber of keeping away from medicine output channel's direction extension including surrounding the outer main cavity that sets up in the outside in inlayer medicine carrying storehouse and communicateing. The technical scheme of the application effectively solves the problem that medicines cannot be provided for the position where the autologous bone of the human body is contacted with the prosthesis structure for a long time in the related technology.

Description

Prosthesis structure

Technical Field

The invention relates to the field of medical instruments, in particular to a prosthesis structure.

Background

In the related art, after the prosthesis structure is implanted into a human body, infection is liable to occur at a position where autologous bones of the human body contact the prosthesis structure. Thus, it is desirable to provide medication to the body at the location where the autologous bone is in contact with the prosthetic structure for an extended period of time to avoid infection. In the related art, the long-term oral administration of antibiotics is generally used to avoid infection, but the oral administration of antibiotics is difficult to completely enter the designated position where the autologous bone of the human body is contacted with the prosthesis structure, and the oral administration of antibiotics can cause side effects such as damage to the liver and kidney functions.

The related art fails to provide a medicine for a long time at a position where autologous bones of the human body contact a prosthesis structure.

Disclosure of Invention

The main purpose of the present invention is to provide a prosthesis structure, which solves the problem of the related art that it is impossible to provide a drug to the position where the autologous bone of the human body contacts the prosthesis structure for a long time.

In order to achieve the above object, the present invention provides a prosthesis structure comprising: a base portion; a porous portion provided at one side of the base portion; medicine carrying portion sets up in base body portion and/or porous portion, and medicine carrying portion includes: a drug output channel having an inlet end and an outlet end; the inner-layer medicine carrying bin is communicated with the medicine output channel and comprises an inner-layer main cavity arranged at the inlet end and an inner-layer expansion cavity which is arranged on the cavity wall of the inner-layer main cavity in a communicated manner and extends towards the direction far away from the medicine output channel; outer drug loading storehouse, with inlayer drug loading storehouse intercommunication, outer drug loading storehouse sets up on the chamber wall of outer main cavity and towards the outer extension chamber of keeping away from medicine output channel's direction extension including surrounding the outer main cavity that sets up in the outside in inlayer drug loading storehouse and communicateing, wherein, is provided with the first passageway of crossing medicine of intercommunication inlayer main cavity and outer main cavity on the inner extension chamber.

Further, the prosthetic structure further comprises: the middle-layer drug-loading bin is arranged between the inner-layer drug-loading bin and the outer-layer drug-loading bin and communicated with the inner-layer drug-loading bin and the outer-layer drug-loading bin.

Further, the inlayer expands the chamber and includes the second inlayer extension chamber that first inlayer extension chamber and a plurality of interval set up, the volume that first inlayer extension chamber is less than the volume of inlayer main cavity, the volume that every second inlayer extension chamber is less than the volume of first inlayer extension chamber, a plurality of second inlayer extension chambers set up on the chamber wall in first inlayer extension chamber and extend towards the direction of keeping away from medicine output channel, first inlayer extension chamber is linked together with a plurality of second inlayer extension chambers, first medicine passageway setting is crossed on the chamber wall in second inlayer extension chamber.

Further, outer extension chamber includes the outer extension chamber of second that first outer extension chamber and a plurality of interval set up, the volume that first outer extension chamber is less than the volume of outer main cavity, the volume that every second outer extension chamber is less than the volume of first outer extension chamber, a plurality of second outer extension chambers set up on the chamber wall in first outer extension chamber and towards the direction extension of keeping away from medicine output channel, first outer extension chamber is linked together with a plurality of second outer extension chambers.

Further, the inner layer main cavity, the first inner layer expansion cavity, the second inner layer expansion cavity, the outer layer main cavity, the first outer layer expansion cavity and the second outer layer expansion cavity are all of spherical structures.

Further, the inner-layer main cavity is communicated with the inner-layer expansion cavity through a first communication port, and the flow area of the first communication port is smaller than the maximum cross-sectional area of the inner-layer expansion cavity; the outer layer main cavity is communicated with the outer layer expansion cavity through a second communication port, and the flow area of the second communication port is smaller than the maximum cross-sectional area of the outer layer expansion cavity.

Further, intermediate level medicine carrying storehouse is a plurality of, and a plurality of intermediate level medicine carrying storehouses set up between inner layer medicine carrying storehouse and outer layer medicine carrying storehouse nested each other, communicate each other between a plurality of intermediate level medicine carrying storehouses.

Further, intermediate level medicine carrying storehouse sets up on the chamber wall of intermediate level main cavity and towards the intermediate level extension chamber that the direction of keeping away from medicine output channel including surrounding the intermediate level main cavity that sets up in the outside in intermediate level medicine carrying storehouse and communicateing, wherein, is provided with the second on the intermediate level extension chamber and crosses the medicine passageway, and the second crosses outer medicine carrying storehouse of medicine passageway intercommunication and intermediate level medicine carrying storehouse, first medicine carrying storehouse and the inner drug carrying storehouse of medicine passageway intercommunication intermediate level.

Further, the drug delivery channel extends along the direction from the porous part to the base body part, and the inner drug-loaded bin and the outer drug-loaded bin are arranged in a protruding mode in the direction from the porous part to the base body part.

Further, the medicine carrying parts are multiple and are arranged in the porous part at intervals; the inner expansion cavities are arranged on the cavity wall of the inner main cavity at intervals, the outer expansion cavities are arranged on the cavity wall of the outer main cavity at intervals; the minimum distance between the main cavity of the outer layer and the side of the porous part far away from the base part is in the range of 1mm to 2mm.

By applying the technical scheme of the invention, the prosthesis structure comprises: a base portion, a porous portion, and a drug-carrying portion. The porous part is arranged on one side of the base part, and after the prosthesis structure is implanted into a human body, the porous part is contacted with the autologous bone of the human body, so that the autologous bone of the human body can grow into the porous part conveniently, and the stability of the prosthesis structure after being implanted into the human body is improved. The medicine carrying portion is provided in the base body portion and/or the porous portion, and the medicine carrying portion includes: the medicine delivery passage, inner layer medicine carrying storehouse and outer layer medicine carrying storehouse. The drug delivery channel has an inlet end and an outlet end. The inner layer drug-loaded bin and the outer layer drug-loaded bin are communicated through the first drug passing channel, so that the inner layer drug-loaded bin and the outer layer drug-loaded bin are communicated with the drug output channel, and drugs in the inner layer drug-loaded bin and the outer layer drug-loaded bin are conveniently conveyed to the position where autologous bones of a human body are contacted with the prosthesis structure through the drug output channel. Inner layer medicine carrying storehouse sets up on the chamber wall of inner layer main cavity and towards the inlayer extension chamber that extends of the direction of keeping away from medicine output channel including setting up the inner layer main cavity of import end department and communicateing, and the setting in inlayer extension chamber has enlarged the volume in inner layer medicine carrying storehouse, makes inner layer medicine carrying storehouse can hold more medicines. Outer medicine carrying storehouse and inlayer medicine carrying storehouse intercommunication, outer medicine carrying storehouse including encircle the outer main cavity that sets up in the outside in inlayer medicine carrying storehouse and set up on the chamber wall of outer main cavity and towards the outer extension chamber of keeping away from medicine output channel's direction extension with communicateing. The size of the outer drug-loaded bin is enlarged due to the arrangement of the outer expansion cavity, so that more drugs can be contained in the outer drug-loaded bin. Wherein, for the convenience of the intercommunication in inlayer year medicine storehouse and outer layer year medicine storehouse, be provided with the first passageway of crossing of intercommunication inlayer main cavity and outer main cavity on the inlayer extension chamber. The medicine in the outer medicine carrying bin needs to pass through the first medicine passing channel, the inner medicine carrying bin and the medicine output channel in sequence and is conveyed to the position where the autologous bone of the human body is contacted with the prosthesis structure, so that the time for the medicine in the outer medicine carrying bin to reach the position where the autologous bone of the human body is contacted with the prosthesis structure is prolonged, the time for the prosthesis structure to provide the medicine for the position where the autologous bone of the human body is contacted with the prosthesis structure is prolonged, and the purpose of medicine slow release is achieved. Therefore, the technical scheme of the application effectively solves the problem that medicines cannot be provided for a long time at the position where the autologous bone of the human body is contacted with the prosthesis structure in the related art.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the invention and, together with the description, serve to explain the invention and not to limit the invention. In the drawings:

FIG. 1 shows a schematic cross-sectional view of an embodiment of a prosthetic structure according to the invention;

FIG. 2 shows a close-up view at A of the prosthesis structure of FIG. 1;

fig. 3 shows a partial enlargement at B of the prosthesis structure of fig. 2.

Wherein the figures include the following reference numerals:

10. a base portion;

20. a porous portion;

30. a drug-carrying section;

31. an inner drug-carrying bin; 311. an inner main chamber; 312. an inner expansion cavity; 3121. a first inner expansion cavity; 3122. a second inner expansion chamber; 313. a first drug passage; 314. a first communication port;

32. a middle drug-carrying bin; 321. a middle layer main cavity; 322. an intermediate layer expansion cavity; 3221. a first intermediate layer expansion cavity; 3222. a second intermediate layer expansion cavity; 323. a second drug passage; 324. a second communication port;

33. an outer drug-carrying bin; 331. an outer layer main cavity; 332. an outer expansion chamber; 3321. a first outer expansion cavity; 3322. a second outer expansion cavity;

34. a drug delivery channel; 341. an inlet end; 342. an outlet end;

40. autologous bone of the human body.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the invention, its application, or uses. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

The relative arrangement of the components and steps, the numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless it is specifically stated otherwise. Meanwhile, it should be understood that the sizes of the respective portions shown in the drawings are not drawn in an actual proportional relationship for the convenience of description. Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate. In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values. It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, further discussion thereof is not required in subsequent figures.

As shown in fig. 1 and 2, the prosthesis structure of the present embodiment includes: a base portion 10, a porous portion 20, and a drug-carrying portion 30. The porous portion 20 is provided on one side of the base portion 10. The medicine carrying part 30 is provided in the porous part 20, and the medicine carrying part 30 includes: a drug delivery channel 34, an inner drug-loaded chamber 31 and an outer drug-loaded chamber 33. The drug delivery channel 34 has an inlet end 341 and an outlet end 342. The inner drug-loaded chamber 31 is communicated with the drug output channel 34, and the inner drug-loaded chamber 31 comprises an inner main chamber 311 arranged at the inlet end 341 and an inner expanding chamber 312 which is arranged on the chamber wall of the inner main chamber 311 in a communicating manner and extends towards the direction far away from the drug output channel 34. Outer layer cartridge 33 and inner layer cartridge 31 intercommunication, outer layer cartridge 33 is including surrounding the outer main cavity 331 that sets up the outside in inner layer cartridge 31 and communicateing and set up on the chamber wall of outer main cavity 331 and towards the outer extension chamber 332 that extends of the direction of keeping away from medicine output channel 34. Wherein, the inner layer expanding cavity 312 is provided with a first drug passing channel 313 communicating the inner layer main cavity 311 and the outer layer main cavity 331.

By applying the technical solution of this embodiment, the prosthesis structure includes: a base portion 10, a porous portion 20, and a drug-carrying portion 30. The porous portion 20 is disposed at one side of the base portion 10, and after the prosthesis structure is implanted into a human body, the porous portion 20 contacts with the autologous bone of the human body so that the autologous bone of the human body can grow into the porous portion 20, thereby increasing the stability of the prosthesis structure after being implanted into the human body. The medicine-carrying part 30 is provided in the porous part 20, and the medicine-carrying part 30 includes: a drug delivery channel 34, an inner drug-loaded chamber 31 and an outer drug-loaded chamber 33. The drug delivery channel 34 has an inlet end 341 and an outlet end 342. The inner drug-loaded bin 31 and the outer drug-loaded bin 33 are communicated through a first drug passing channel 313, so that the inner drug-loaded bin 31 and the outer drug-loaded bin 33 are both communicated with a drug output channel 34, and drugs in the inner drug-loaded bin 31 and the outer drug-loaded bin 33 can be conveniently conveyed to the position where autologous bones of a human body are contacted with a prosthesis structure through the drug output channel 34. The inner drug-loaded bin 31 comprises an inner main cavity 311 arranged at the inlet end 341 and an inner expanding cavity 312 which is arranged on the cavity wall of the inner main cavity 311 in a communicating manner and extends towards the direction far away from the drug output channel 34, and the volume of the inner drug-loaded bin 31 is enlarged by the arrangement of the inner expanding cavity 312, so that more drugs can be contained in the inner drug-loaded bin 31. Outer layer cartridge 33 and inner layer cartridge 31 intercommunication, outer layer cartridge 33 is including surrounding the outer main cavity 331 that sets up the outside in inner layer cartridge 31 and communicateing and set up on the chamber wall of outer main cavity 331 and towards the outer extension chamber 332 that extends of the direction of keeping away from medicine output channel 34. The provision of the outer expanding cavity 332 enlarges the volume of the outer drug-loaded cartridge 33, enabling the outer drug-loaded cartridge 33 to hold more drug. In order to facilitate the communication between the inner-layer drug loading bin 31 and the outer-layer drug loading bin 33, a first drug passing channel 313 communicating the inner-layer main cavity 311 and the outer-layer main cavity 331 is arranged on the inner-layer expansion cavity 312. The medicine in the outer-layer medicine carrying bin 33 needs to pass through the first medicine passing channel 313, the inner-layer medicine carrying bin 31 and the medicine output channel 34 in sequence and be conveyed to the position where the autologous bone of the human body is contacted with the prosthesis structure, so that the time for the medicine in the outer-layer medicine carrying bin 33 to reach the position where the autologous bone of the human body is contacted with the prosthesis structure is prolonged, the time for the prosthesis structure to provide the medicine for the position where the autologous bone of the human body is contacted with the prosthesis structure is prolonged, and the purpose of slow release of the medicine is achieved. Therefore, the technical scheme of the embodiment effectively solves the problem that the medicine cannot be provided for a long time at the position where the autologous bone of the human body is contacted with the prosthesis structure in the related art.

It should be noted that the inlet end 341 is the end of the drug delivery channel 34 connected to the wall of the inner main lumen 311, and the outlet end 342 is the end of the drug delivery channel 34 facing away from the base portion 10. After the prosthesis structure is implanted into a human body, the outlet end 342 is communicated with the autologous bone of the human body, the medicine in the medicine loading part 30 is delivered to the position where the autologous bone of the human body is contacted with the prosthesis structure through the medicine output channel 34, and at the moment, the medicine in the medicine output channel 34 is delivered to the outlet end 342 through the inlet end 341.

Furthermore, the prosthesis structure is suitable for a prosthesis structure which is in contact with bone and needs slow release of the drug, and the prosthesis structure of the embodiment has the function of slow release of the drug, can continuously exert the efficacy of the drug and prolongs the release time of the drug. According to the corresponding design of the required medicine quantity and the medicine carrying cavity volume, the aim of realizing medicine treatment in a specified period can be fulfilled. And the prosthesis structure of the embodiment can realize the functions of function replacement of autologous bones, focus treatment and body growth promotion. The prosthetic structure may be a joint prosthesis or a bone defect patch, for example: hip joint prosthesis, knee joint prosthesis, hip bone defect patch, knee bone defect patch.

In this embodiment, the base portion 10, the porous portion 20 and the drug-carrying portion 30 of the prosthesis structure are an integral structure, and are formed by a metal 3D printing technique using an electron beam melting technique. The metal 3D printing technology of the electron beam melting technology belongs to the additive manufacturing category and can process special-shaped complex structures.

In embodiments not shown in the figures, the drug carrying part is provided in the base part, or a part of the drug carrying part is provided in the base part and another part is provided in the porous part.

As shown in figures 1 and 2, the prosthesis structure further comprises a middle drug-loaded chamber 32, and the middle drug-loaded chamber 32 is arranged between the inner drug-loaded chamber 31 and the outer drug-loaded chamber 33 and communicated with the inner drug-loaded chamber 31 and the outer drug-loaded chamber 33. The medicine in the outer medicine carrying bin 33 can reach the inner medicine carrying bin 31 only through the middle medicine carrying bin 32, and then is output to the position where the autologous bone of the human body is contacted with the prosthesis structure through the medicine output channel 34 communicated with the inner medicine carrying bin 31, so that the time for the medicine in the outer medicine carrying bin 33 to reach the position where the autologous bone of the human body is contacted with the prosthesis structure is further increased.

As shown in fig. 1 and 2, the inner expansion cavity 312 includes a first inner expansion cavity 3121 and a plurality of spaced apart second inner expansion cavities 3122, and the arrangement of the plurality of second inner expansion cavities 3122 further expands the volume of the inner expansion cavity 312, so that the inner expansion cavity 312 can contain more medicament. The volume of the first inner expansion cavity 3121 is smaller than the volume of the inner main cavity 311, and the volume of each second inner expansion cavity 3122 is smaller than the volume of the first inner expansion cavity 3121. The plurality of second inner expansion cavities 3122 are disposed on the cavity wall of the first inner expansion cavity 3121 and extend in a direction away from the medicine output passage 34, the first inner expansion cavity 3121 is communicated with the plurality of second inner expansion cavities 3122, and the first medicine passage 313 is disposed on the cavity wall of the second inner expansion cavity 3122. Thus, the drugs in the middle-layer drug-loading bin 32 need to sequentially pass through the first drug passing channel 313, the second inner-layer expansion cavity 3122 and the first inner-layer expansion cavity 3121 to enter the inner-layer main cavity 311, and the time for the drugs in the middle-layer drug-loading bin 32 to enter the inner-layer main cavity 311 can be further prolonged due to the sequential reduction of the volumes of the inner-layer main cavity 311, the first inner-layer expansion cavity 3121 and the second inner-layer expansion cavity 3122.

As shown in FIGS. 1 and 2, the outer expansion chamber 332 includes a first outer expansion chamber 3321 and a plurality of spaced apart second outer expansion chambers 3322, the arrangement of the plurality of second outer expansion chambers 3322 further increases the volume of the outer expansion chamber 332 to allow the outer expansion chamber 332 to hold more medicament. The first outer expansion chamber 3321 has a volume smaller than that of the outer main chamber 331, each of the second outer expansion chambers 3322 has a volume smaller than that of the first outer expansion chamber 3321, a plurality of second outer expansion chambers 3322 are provided on the wall of the first outer expansion chamber 3321 and extend in a direction away from the drug delivery path 34, and the first outer expansion chamber 3321 is communicated with the plurality of second outer expansion chambers 3322. Thus, the drug in the second outer expansion cavity 3322 needs to enter the outer main cavity 331 through the second outer expansion cavity 3322, and the time for the drug in the second outer expansion cavity 3322 to enter the outer main cavity 331 can be further prolonged due to the sequential reduction of the volumes of the outer main cavity 331, the first outer expansion cavity 3321 and the second outer expansion cavity 3322.

As shown in fig. 1 and 2, the inner main cavity 311, the first inner expansion cavity 3121, the second inner expansion cavity 3122, the outer main cavity 331, the first outer expansion cavity 3321, and the second outer expansion cavity 3322 are all spherical structures. The spherical structure is larger in volume and can contain more medicaments. And the spherical structure simulates the structure of human alveolus, so that the drug loading capacity is further improved.

In an embodiment not shown in the figures, the inner main cavity, the first inner extension cavity, the second inner extension cavity, the outer main cavity, the first outer extension cavity, and the second outer extension cavity may be triangular pyramids, triangular prisms, or cubes.

As shown in fig. 1 to 3, the inner layer main chamber 311 communicates with the inner layer expansion chamber 312 through the first communication port 314, and the flow area of the first communication port 314 is smaller than the maximum cross-sectional area of the inner layer expansion chamber 312. That is, inner layer main cavity 311 is a major arc (an arc larger than a semicircle) in a sectional view through the center of the sphere of the spherical structure of inner layer main cavity 311. This prevents a portion of the drug in the inner extension chamber 312 from directly discharging from the first communication port 314 to the inner main chamber 311, and prolongs the time period during which the drug in the inner extension chamber 312 is transferred to the inner main chamber 311.

As shown in fig. 1 to 3, the outer-layer main chamber 331 communicates with the outer-layer expansion chamber 332 through the second communication port 324, and the flow area of the second communication port 324 is smaller than the maximum cross section of the outer-layer expansion chamber 332. That is, the outer layer main cavity 331 has a major arc (arc larger than a semicircle) in a sectional view through the center of the sphere of the spherical structure of the outer layer main cavity 331. This prevents a portion of the drug in the outer expansion chamber 332 from being discharged directly from the second communication port 324 to the outer main chamber 331, and prolongs the period of time during which the drug in the outer expansion chamber 332 is delivered to the outer main chamber 331.

Specifically, the inner layer main cavity 311, the first inner layer expansion cavity 3121, the second inner layer expansion cavity 3122, the outer layer main cavity 331, the first outer layer expansion cavity 3321, and the second outer layer expansion cavity 3322 are all of a segment structure. The first communication port 314 is a bottom surface of the spherical segment structure of the first inner expansion chamber 3121, and the second communication port 324 is a bottom surface of the spherical segment structure of the first outer expansion chamber 3321.

As shown in fig. 1 to 3, in the present embodiment, there is one drug-loading cavity in the middle layer.

In the embodiment not shown in the figure, the intermediate layer medicine carrying bin is multiple, the multiple intermediate layer medicine carrying bins are nested with each other and are arranged between the inner layer medicine carrying bin and the outer layer medicine carrying bin, and the multiple intermediate layer medicine carrying bins are communicated with each other. Like this, the medicine in outer medicine carrying cavity need carry inlayer medicine carrying cavity through a plurality of intermediate level medicine carrying storehouses, has further increased the time that the medicine in outer medicine carrying cavity reachs inlayer medicine carrying cavity to the position department that medicine output channel intercommunication through being linked together with inlayer medicine carrying cavity is human autologous bone and prosthetic structures contact provides the medicine for a long time.

As shown in fig. 1 to fig. 3, the middle layer drug loading chamber 32 includes a middle layer main chamber 321 disposed around the outer side of the middle layer drug loading chamber 32, and a middle layer expanding chamber 322 disposed on the chamber wall of the middle layer main chamber 321 and extending toward the direction away from the drug output channel 34. The intermediate layer expansion cavity 322 enlarges the volume of the intermediate layer drug-loaded bin 32, so that the intermediate layer drug-loaded bin 32 can contain more drugs. The middle layer expanding cavity 322 is provided with a second medicine passing channel 323, the second medicine passing channel 323 is communicated with the outer layer medicine carrying bin 33 and the middle layer medicine carrying bin 32, and the first medicine passing channel 313 is communicated with the middle layer medicine carrying bin 32 and the inner layer medicine carrying bin 31. The first drug passing channel 313 and the second drug passing channel 323 are arranged to enable the drug in the outer drug loading bin 33 to be delivered to the middle drug loading bin 32 and the inner drug loading bin 31.

In this embodiment, the middle tier expansion cavity 322 comprises a first middle tier expansion cavity 3221 and a plurality of second middle tier expansion cavities 3222 arranged in spaced relation. The volume of the first intermediate layer expansion cavity 3221 is less than the volume of the intermediate layer main cavity 321, and the volume of each second intermediate layer expansion cavity 3222 is less than the volume of the first intermediate layer expansion cavity 3221. The plurality of second middle layer expansion cavities 3222 are arranged on the cavity wall of the first middle layer expansion cavity 3221 and extend towards the direction away from the medicine output channel 34, the first middle layer expansion cavity 3221 is communicated with the plurality of second middle layer expansion cavities 3222, and the second medicine passing channel 323 is arranged on the cavity wall of the second middle layer expansion cavity 3222. Further, the first medicine passing channel 313 is arranged on the wall of the second inner expansion cavity 3122, and the flow area of the first medicine passing channel 313 is smaller than the maximum cross-sectional area of the second inner expansion cavity 3122. Therefore, along with the movement of the human body, the medicine can slowly enter the second inner layer expanding cavity 3122 from the middle layer main cavity 321, the delivery time of the medicine is prolonged, and the medicine slow release effect is further achieved.

Further, the second drug passing channel 323 is arranged on the wall of the second middle expansion cavity 3222, and the flow area of the second drug passing channel 323 is smaller than the maximum cross-sectional area of the second middle expansion cavity 3222. Therefore, along with the movement of the human body, the medicine can slowly enter the second middle layer expanding cavity 3222 from the outer middle layer main cavity, so that the delivery time of the medicine is prolonged, and the slow release effect of the medicine is further achieved.

As shown in fig. 1 to 3, the drug delivery channel 34 extends along the direction from the porous portion 20 to the base portion 10, and the inner drug carrying chamber 31 and the outer drug carrying chamber 33 are arranged to protrude in the direction from the porous portion 20 to the base portion 10, so that the drug delivery channel 34 is communicated with the inner drug carrying chamber 31, and the drug in the drug carrying chambers is delivered to the position of the autogenous bone of the human body in contact with the porous portion 20.

In the present embodiment, the drug delivery channel 34 extends vertically in the direction from the porous portion 20 to the base body portion 10, and the inner drug-loaded cartridge 31 and the outer drug-loaded cartridge 33 are disposed to protrude vertically in the direction from the porous portion 20 to the base body portion 10.

In the embodiment not shown in the figures, the drug delivery channel extends non-vertically along the direction from the porous part to the basal body part, and the inner drug-loaded cartridge and the outer drug-loaded cartridge are arranged in a non-vertical protruding manner along the direction from the porous part to the basal body part according to the shape requirement and the mechanical property requirement of the prosthesis structure.

As shown in fig. 1 to 3, the medicine-carrying portion 30 is plural, and the plural medicine-carrying portions 30 are disposed at intervals in the porous portion 20. The inner expansion chamber 312 is plural, and the plural inner expansion chambers 312 are arranged at intervals on the chamber wall of the inner main chamber 311. The arrangement of the plurality of inner expanding cavities 312 enlarges the volume of the inner drug-loaded cavity, and further enables the inner drug-loaded cartridge 31 to contain more drugs. The outer layer expansion cavity 332 is multiple, and the multiple outer layer expansion cavities 332 are arranged on the cavity wall of the outer layer main cavity 331 at intervals. The provision of the plurality of outer expansion cavities 332 enlarges the volume of the outer drug-loaded cavity, further enabling the outer drug-loaded cartridge 33 to hold more drug.

As shown in fig. 1 to 3, since the depth required for the autogenous bone of the human body to grow into the porous portion 20 is less than 1mm, the minimum distance between the outer layer main chamber 331 and the side of the porous portion 20 away from the base portion 10 is in the range of 1mm to 2mm. Therefore, the contact area between the autologous bone of the human body and the porous structure can be increased, the autologous bone of the human body can grow into the porous part 20 conveniently, and the stability of the prosthesis structure implanted into the human body is increased. In the present embodiment, the minimum distance between the outer layer main cavity 331 and the side of the porous portion 20 away from the base portion 10 is preferably 1mm or 1.2mm or 1.5mm or 1.8mm or 2mm.

In this embodiment, the middle layer expansion cavity 322 is plural, and the plural middle layer expansion cavities 322 are arranged on the cavity wall of the middle layer main cavity 321 at intervals.

Further, the thickness of the porous part 20 is in the range of 5mm to 15mm, and the drug loading amount of each drug-loaded part 30 is in the range of 1ml to 5 ml. The medicine is loaded into the medicine loading portion 30 by soaking, injecting or squeezing, and when the medicine is loaded into the medicine loading portion 30, the medicine sequentially passes through the outlet end 342 of the medicine output channel 34, the inlet end 341 of the medicine output channel 34, the inner layer main cavity 311, the inner layer expansion cavity 312, the intermediate layer main cavity 321, the intermediate layer expansion cavity 322, the outer layer main cavity 331 and the outer layer expansion cavity 332, so as to fill the medicine loading portion 30. The prosthesis structure in this embodiment can load multiple medicine through injecting or extruding different medicines in the medicine carrying cavity of difference to reach better treatment. In the present embodiment, the thickness of the porous portion 20 is preferably 5mm or 8mm or 10mm or 12mm or 15mm.

In this embodiment, there is one inner layer main cavity 311 of one drug carrying part 30, one inner layer expansion cavity 312 is arranged on the vertex of the spherical surface of one spherical inner layer main cavity 311, six inner layer expansion cavities 312 arranged on the spherical section of the spherical inner layer main cavity 311 are surrounded around the one inner layer expansion cavity 312 on the vertex of the spherical surface, and twelve inner layer expansion cavities 312 are arranged on the spherical section of the one spherical inner layer main cavity 311 away from the base body 10. In the embodiment not shown in the figure, the increase of the number of the extension cavities of the inner layer facilitates the increase of the drug loading amount according to the requirement of clinical application and the premise of meeting the mechanical property.

In this embodiment, one intermediate layer main cavity 321 of one drug loading part 30 is provided, one intermediate layer expansion cavity 322 is provided at the vertex of the spherical surface of one intermediate layer main cavity 321 of the spherical structure, six intermediate layer expansion cavities 322 provided on the spherical section of the intermediate layer main cavity 321 of the spherical structure are surrounded around one intermediate layer expansion cavity 322 at the vertex of the spherical surface, and twelve intermediate layer expansion cavities 322 are provided on the spherical section of one intermediate layer main cavity 321 of the spherical structure, which is away from the base body part 10. In the embodiment not shown in the figure, the increased number of the middle layer expansion cavities facilitates the increase of drug loading according to the requirements of clinical application and on the premise of meeting the mechanical property.

In this embodiment, there is one outer layer main cavity 331 of one drug-loading part 30, one outer layer expansion cavity 332 is disposed at the vertex of the spherical surface of one outer layer main cavity 331 of the spherical structure, six outer layer expansion cavities 332 disposed on the spherical section of the outer layer main cavity 331 of the spherical structure are surrounded around one outer layer expansion cavity 332 at the vertex of the spherical surface, and twelve outer layer expansion cavities 332 are disposed on the spherical section of one outer layer main cavity 331 of the spherical structure, which is away from the base body 10. In the embodiment not shown in the figure, the increase of the number of the outer expansion cavities facilitates the increase of the drug loading amount according to the requirements of clinical application and the premise of meeting the mechanical property.

In an embodiment not shown in the figures, the inner drug-loaded chamber, the middle drug-loaded chamber and the outer drug-loaded chamber are arranged in the base portion, the inner main chamber of the inner drug-loaded chamber is communicated with the inlet end of the drug delivery channel, and the outlet end of the drug delivery channel is arranged through the porous portion to be communicated with the outside of the prosthesis structure.

In an embodiment not shown in the figures, a portion of the inner drug-loading chamber, a portion of the middle drug-loading chamber and a portion of the outer drug-loading chamber are disposed in the base portion, another portion of the inner drug-loading chamber, another portion of the middle drug-loading chamber and another portion of the outer drug-loading chamber are disposed in the porous portion, the inner main chamber 311 of the inner drug-loading chamber is in communication with the inlet end of the drug delivery channel, and the outlet end of the drug delivery channel is in communication with the exterior of the prosthetic structure.

In the description of the present invention, it is to be understood that the orientation or positional relationship indicated by the orientation words such as "front, rear, upper, lower, left, right", "lateral, vertical, horizontal" and "top, bottom", etc. are usually based on the orientation or positional relationship shown in the drawings, and are only for convenience of description and simplicity of description, and in the case of not making a reverse description, these orientation words do not indicate and imply that the device or element being referred to must have a specific orientation or be constructed and operated in a specific orientation, and therefore, should not be considered as limiting the scope of the present invention; the terms "inner and outer" refer to the inner and outer relative to the profile of the respective component itself.

For ease of description, spatially relative terms such as "above … …", "above … …", "above … … upper surface", "above", etc. may be used herein to describe the spatial positional relationship of one device or feature to other devices or features as shown in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is turned over, devices described as "above" or "on" other devices or configurations would then be oriented "below" or "under" the other devices or configurations. Thus, the exemplary term "above … …" may include both orientations of "above … …" and "below … …". The device may be otherwise variously oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

It should be noted that the terms "first", "second", and the like are used to define the components, and are only used for convenience of distinguishing the corresponding components, and the terms have no special meanings unless otherwise stated, and therefore, the scope of the present invention should not be construed as being limited.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A prosthetic structure, comprising:

a base portion (10);

a porous portion (20) provided on one side of the base portion (10);

a drug-loaded portion (30) disposed within the base portion (10) and/or the porous portion (20), the drug-loaded portion (30) comprising:

a drug output channel (34), the drug output channel (34) having an inlet end (341) and an outlet end (342);

an inner drug-loaded cartridge (31) in communication with the drug delivery channel (34), the inner drug-loaded cartridge (31) comprising an inner main chamber (311) disposed at the inlet end (341) and an inner expansion chamber (312) communicatively disposed on a chamber wall of the inner main chamber (311) and extending in a direction away from the drug delivery channel (34);

outer layer cartridge medicine storehouse (33), with inner layer cartridge medicine storehouse (31) intercommunication, outer cartridge medicine storehouse (33) is including encircleing the setting and being in outer main cavity (331) and the ground setting in the outside of inner layer cartridge medicine storehouse (31) are in just towards keeping away from on the chamber wall of outer main cavity (331) the outer extension chamber (332) of the direction extension of medicine output channel (34), wherein, be provided with the intercommunication on inner layer extension chamber (312) inner layer main cavity (311) with first medicine passageway (313) of crossing of outer main cavity (331).

2. The prosthetic structure of claim 1, further comprising:

the middle-layer medicine carrying bin (32) is arranged between the inner-layer medicine carrying bin (31) and the outer-layer medicine carrying bin (33) and communicated with the inner-layer medicine carrying bin (31) and the outer-layer medicine carrying bin (33).

3. The prosthetic structure of claim 1,

the inner layer expansion cavity (312) comprises a first inner layer expansion cavity (3121) and a plurality of spaced apart second inner layer expansion cavities (3122), the volume of the first inner layer expansion cavity (3121) is smaller than that of the inner layer main cavity (311), the volume of each second inner layer expansion cavity (3122) is smaller than that of the first inner layer expansion cavity (3121), the plurality of second inner layer expansion cavities (3122) are disposed on the cavity wall of the first inner layer expansion cavity (3121) and extend in a direction away from the drug output channel (34), the first inner layer expansion cavity (3121) is communicated with the plurality of second inner layer expansion cavities (3122), and the first drug passing channel (313) is disposed on the cavity wall of the second inner layer expansion cavity (3122).

4. The prosthetic structure of claim 3,

outer layer extension chamber (332) includes first outer layer extension chamber (3321) and a plurality of second outer layer extension chamber (3322) that the interval set up, the volume of first outer layer extension chamber (3321) is less than the volume of outer layer main chamber (331), every the volume of second outer layer extension chamber (3322) is less than the volume of first outer layer extension chamber (3321), and is a plurality of second outer layer extension chamber (3322) sets up on the chamber wall of first outer layer extension chamber (3321) and keep away from the direction of medicine output channel (34) extends, first outer layer extension chamber (3321) is with a plurality of second outer layer extension chamber (3322) is linked together.

5. The prosthetic structure of claim 4, wherein the inner main lumen (311), the first inner expansion lumen (3121), the second inner expansion lumen (3122), the outer main lumen (331), the first outer expansion lumen (3321), and the second outer expansion lumen (3322) are all spherical structures.

6. The prosthetic structure of claim 5,

the inner-layer main cavity (311) is communicated with the inner-layer expansion cavity (312) through a first communication port (314), and the flow area of the first communication port (314) is smaller than the maximum cross-sectional area of the inner-layer expansion cavity (312);

the outer layer main cavity (331) is communicated with the outer layer expansion cavity (332) through a second communication port (324), and the flow area of the second communication port (324) is smaller than the maximum cross-sectional area of the outer layer expansion cavity (332).

7. The prosthesis structure of claim 2, wherein the intermediate drug loading bin (32) is a plurality of drug loading bins, the intermediate drug loading bins (32) are nested with each other and are arranged between the inner drug loading bin (31) and the outer drug loading bin (33), and the intermediate drug loading bins (32) are communicated with each other.

8. The prosthesis structure of claim 2, wherein the middle layer drug loading chamber (32) comprises a middle layer main chamber (321) surrounding the outer side of the middle layer drug loading chamber (32) and a middle layer expanding chamber (322) communicatively disposed on the chamber wall of the middle layer main chamber (321) and extending in a direction away from the drug output channel (34), wherein a second drug passing channel (323) is disposed on the middle layer expanding chamber (322), the second drug passing channel (323) communicates the outer layer drug loading chamber (33) and the middle layer drug loading chamber (32), and the first drug passing channel (313) communicates the middle layer drug loading chamber (32) and the inner layer drug loading chamber (31).

9. The prosthetic arrangement according to claim 1, characterized in that the drug delivery channel (34) extends in the direction from the porous portion (20) to the base portion (10), the inner drug-loaded cartridge (31) and the outer drug-loaded cartridge (33) being arranged protruding in the direction from the porous portion (20) to the base portion (10).

10. The prosthetic structure of claim 1, wherein the drug carrying portion (30) is plural, and plural drug carrying portions (30) are provided at intervals in the porous portion (20); the inner expansion cavities (312) are multiple, a plurality of inner expansion cavities (312) are arranged on the cavity wall of the inner main cavity (311) at intervals, the outer expansion cavities (332) are multiple, and a plurality of outer expansion cavities (332) are arranged on the cavity wall of the outer main cavity (331) at intervals; the minimum distance between the outer layer main cavity (331) and the side of the porous portion (20) away from the base portion (10) is in the range of 1mm to 2mm.