CN115436637A - Blood glucose detection method and device and blood glucose detection equipment - Google Patents
Blood glucose detection method and device and blood glucose detection equipment Download PDFInfo
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Abstract
The application is applicable to the technical field of electrochemical detection, and provides a blood glucose detection method, a blood glucose detection device, blood glucose detection equipment and a computer readable storage medium, wherein the method comprises the following steps: the method comprises the steps that a blood sample to be detected is contacted with biological enzyme on blood glucose test paper, the blood glucose current value of the blood sample to be detected is acquired at a first preset time point after voltage is applied to a first pair of electrodes by acquiring the hematocrit background current value of the blood sample to be detected, and then the blood glucose current value of the blood sample to be detected is acquired at a second preset time point after voltage is applied to a second pair of electrodes; and determining the blood glucose concentration of the blood sample to be tested according to the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test paper, so that the blood glucose concentration is converted according to the compensation coefficient corresponding to the blood glucose test paper, the hematocrit background current value and the blood glucose current value, the interference of hematocrit on blood glucose test is obviously reduced, and the accuracy of a blood glucose test result is improved.
Description
Technical Field
The present application relates to the field of electrochemical detection technologies, and in particular, to a blood glucose detection method and apparatus, a blood glucose detection device, and a computer-readable storage medium.
Background
The electrochemical method is earlier applied to a biosensor for detecting a target object in blood, such as glucose, the reaction principle is that the blood to be detected is contacted with a biological enzyme reagent fixed on the biosensor, an electron gain and loss process is generated on the surface of an electrode by an active substance under an external voltage, the gain and loss electrons are conducted along the electrode to generate current, and the current is in direct proportion to the concentration of the substance, so that the detected current is converted into the concentration of the blood glucose to be displayed.
The current blood sugar detection method is easily interfered by the hematocrit in blood in the test process, so that the error of the blood sugar test result is larger.
Disclosure of Invention
The blood glucose detection method, the blood glucose detection device, the blood glucose detection equipment and the computer readable storage medium provided by the embodiment of the application can solve the problem that the error of a blood glucose test result is large due to the fact that the blood glucose test result is easily interfered by the hematocrit in blood in the test process.
In a first aspect, an embodiment of the present application provides a blood glucose detecting method, including:
collecting the background current value of the hematocrit of the blood sample to be detected at a first preset time point after the blood sample to be detected is contacted with the biological enzyme on the blood glucose test paper and the voltage is applied to the first pair of electrodes; collecting the blood glucose current value of the blood sample to be detected at a second preset time point after the voltage is applied to the second pair of electrodes; and determining the blood glucose concentration of the blood sample to be detected according to the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test paper.
In a second aspect, an embodiment of the present application provides a blood glucose detecting device, including:
the first acquisition module is used for acquiring a background current value of hematocrit of a blood sample to be detected at a first preset time point after the blood sample to be detected is contacted with biological enzyme on the blood glucose test paper and voltage is applied to the first pair of electrodes; the second acquisition module is used for acquiring the blood glucose current value of the blood sample to be detected at a second preset time point after the voltage is applied to the second counter electrode; and the detection module is used for determining the blood glucose concentration of the blood sample to be detected according to the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test paper.
In a third aspect, an embodiment of the present application provides a blood glucose detecting apparatus, including a memory, a processor, and a computer program stored in the memory and executable on the processor, where the processor implements the blood glucose detecting method according to any one of the above first aspects when executing the computer program.
In a fourth aspect, the present application provides a computer-readable storage medium, which stores a computer program, and when the computer program is executed by a processor, the computer program implements the blood glucose detecting method according to any one of the first aspect.
In a fifth aspect, the present application provides a computer program product, which, when run on a blood glucose detecting device, causes the blood glucose detecting device to perform the blood glucose detecting method according to any one of the above first aspects.
It is understood that the beneficial effects of the second aspect to the fifth aspect can be referred to the related description of the first aspect, and are not described herein again.
Compared with the prior art, the embodiment of the application has the advantages that: the method comprises the steps that a blood sample to be tested is contacted with biological enzyme on a blood glucose test paper, the blood glucose concentration of the blood sample to be tested is determined according to a hematocrit background current value of the blood sample to be tested and a second preset time point after voltage is applied to a second pair of electrodes after the hematocrit background current value of the blood sample to be tested is collected at the first preset time point after voltage is applied to the first pair of electrodes, and then the blood glucose concentration of the blood sample to be tested is determined according to the hematocrit background current value, the blood glucose current value and a compensation coefficient corresponding to the blood glucose test paper.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the embodiments or the prior art descriptions will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a schematic flow chart of a blood glucose testing method according to an embodiment of the present application;
FIG. 2 is a schematic flow chart of a blood glucose measuring method according to another embodiment of the present application;
FIG. 3 is a schematic structural diagram of a blood glucose testing device according to an embodiment of the present application;
fig. 4 is a schematic structural diagram of a blood glucose detecting device according to an embodiment of the present application.
Detailed Description
In the following description, for purposes of explanation and not limitation, specific details are set forth, such as particular system structures, techniques, etc. in order to provide a thorough understanding of the embodiments of the present application. It will be apparent, however, to one skilled in the art that the present application may be practiced in other embodiments that depart from these specific details. In other instances, detailed descriptions of well-known systems, devices, circuits, and methods are omitted so as not to obscure the description of the present application with unnecessary detail.
It will be understood that the terms "comprises" and/or "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
It should also be understood that the term "and/or" as used in this specification and the appended claims refers to and includes any and all possible combinations of one or more of the associated listed items.
As used in this specification and the appended claims, the term "if" may be interpreted contextually as "when", "upon" or "in response to" determining "or" in response to detecting ". Similarly, the phrase "if it is determined" or "if a [ described condition or event ] is detected" may be interpreted contextually to mean "upon determining" or "in response to determining" or "upon detecting [ described condition or event ]" or "in response to detecting [ described condition or event ]".
Furthermore, in the description of the present application and the appended claims, the terms "first," "second," "third," and the like are used for distinguishing between descriptions and not necessarily for describing a relative importance or importance.
Reference throughout this specification to "one embodiment" or "some embodiments," or the like, means that a particular feature, structure, or characteristic described in connection with the embodiment is included in one or more embodiments of the present application. Thus, appearances of the phrases "in one embodiment," "in some embodiments," "in other embodiments," or the like, in various places throughout this specification are not necessarily all referring to the same embodiment, but rather "one or more but not all embodiments" unless specifically stated otherwise. The terms "comprising," "including," "having," and variations thereof mean "including, but not limited to," unless otherwise specifically stated.
It should be understood that, the sequence numbers of the steps in this embodiment do not mean the execution sequence, and the execution sequence of each process should be determined by the function and the inherent logic of the process, and should not constitute any limitation to the implementation process of the embodiment of the present application.
In the related art, the blood sugar detection method is easily interfered by the hematocrit in the blood in the test process, so that the error of the blood sugar test result is larger.
The application provides a blood sugar detection method, wherein a blood sample to be detected is contacted with biological enzyme on blood sugar test paper, and the blood sugar current value of the blood sample to be detected is acquired at a first preset time point after voltage is applied to a first pair of electrodes by acquiring the hematocrit background current value of the blood sample to be detected and then at a second preset time point after voltage is applied to a second pair of electrodes; and determining the blood glucose concentration of the blood sample to be tested according to the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test paper, so that the blood glucose concentration is converted according to the compensation coefficient corresponding to the blood glucose test paper, the hematocrit background current value and the blood glucose current value, the interference of hematocrit on the blood glucose test is obviously reduced, and the accuracy of the blood glucose test result is improved.
According to the blood sugar detection method, the execution main body can be a blood sugar detection device. In order to explain the technical solution of the present application, the method takes an execution subject as a blood glucose detecting device as an example to explain an implementation process of the blood glucose detecting method provided in the embodiment of the present application.
In one embodiment, referring to fig. 1, a blood glucose test method is provided, by way of example and not limitation, as shown in fig. 1, the blood glucose test method may include the steps of:
The blood sample to be tested can be a blood sample which needs to be subjected to blood glucose detection at present.
The blood glucose test paper can be a blood glucose test paper which is matched with blood glucose detection equipment and coated with biological enzymes. The blood glucose test strip is coated with an ultra-thin conductive layer, and as an example, the conductive layer of the blood glucose test strip includes a counter electrode, a start electrode, a full blood detection electrode, a Red blood cell specific volume (HCT) working electrode, and a blood glucose working electrode.
In a possible implementation manner of the embodiment of the present application, the blood glucose test strip is inserted into a test strip socket of the blood glucose test device, the counter electrode and the starting electrode are in a short circuit state, the blood glucose test device is started and is in a standby state, a blood sample to be tested is placed in a reaction area of the blood glucose test strip, when the reaction area of the blood glucose test strip is full of blood, the counter electrode and the full blood test electrode form a passage, at this time, the blood glucose test device starts to time, the blood sample to be tested is in contact with a bio-enzyme on the blood glucose test strip, after a first preset time interval, a voltage is applied to the first counter electrode and the first counter electrode is timed, that is: and applying a voltage between the counter electrode and the HCT working electrode, wherein the reaction area of the blood glucose test paper generates electrochemical reaction, and collecting the current from the beginning of timing to a first preset time point to generate a current value, wherein the current value is the hematocrit background current value of the blood sample to be detected.
The first preset time point may be a time point after the voltage application to the first pair of electrodes is started, the first preset time point may be determined according to a time when the electrochemical reaction sufficiently occurs in the reaction region of the blood glucose test strip, and the first preset time point may be set to be 1 second, 2 seconds, 3 seconds, or 4 seconds after the voltage application to the first pair of electrodes is started, and the like, which is not limited in this embodiment of the present application. In one example, the hematocrit background current value of the blood sample to be measured is collected 5 seconds after the voltage application to the first pair of electrodes is started, and the first preset time point is 5 seconds after the voltage application to the first pair of electrodes is started.
The first predetermined time interval may be a time interval between the time when the counter electrode and the full blood detection electrode form a passage and the time when the voltage application to the first counter electrode is started. The first predetermined time interval may be determined according to the reaction time of the actual blood sample to be tested and the bio-enzyme on the blood glucose test strip, such as 1 second, 2 seconds or 3 seconds.
It should be understood that, after the interval of the first preset time interval, the first pair of electrodes is started and timed, so that the blood sample to be detected can fully react with the biological enzyme on the blood glucose test paper, and the accuracy of collecting the background current value of the hematocrit can be improved.
It will be appreciated that the first pair of electrodes may be a pair of electrodes consisting of a counter electrode and a HCT working electrode.
And 102, acquiring the blood glucose current value of the blood sample to be detected at a second preset time point after the voltage is applied to the second pair of electrodes.
The second preset time point may be a time point after the voltage is applied to the second pair of electrodes, the second preset time point may be determined according to a time when the electrochemical reaction sufficiently occurs in the reaction region of the blood glucose test strip, and the second preset time point may be set to be 1 second, 2 seconds, 3 seconds, 4 seconds, or the like after the voltage is applied to the second pair of electrodes, which is not limited in the embodiment of the present invention. In one example, the blood glucose current value of the blood sample to be measured is collected 5 seconds after the voltage application to the second pair of electrodes is started, and the second preset time point is 5 seconds after the voltage application to the second pair of electrodes is started.
The second counter electrode can be a pair of electrodes consisting of a counter electrode on the blood glucose test paper and a blood glucose working electrode.
In a possible implementation manner of the embodiment of the present application, the blood glucose test strip is inserted into a test strip socket of the blood glucose test device, the counter electrode and the starting electrode are in a short circuit state, the blood glucose test device is started and is in a standby state, a blood sample to be tested is placed in a reaction area of the blood glucose test strip, when the reaction area of the blood glucose test strip is full of blood, the counter electrode and the full blood test electrode form a passage, at this time, the blood glucose test device starts to time, the blood sample to be tested is in contact with a bio-enzyme on the blood glucose test strip, after a first preset time interval, a voltage is applied to the first counter electrode and the first counter electrode is timed, that is: applying a voltage between the counter electrode and the HCT working electrode, wherein an electrochemical reaction occurs in a reaction area of the blood glucose test paper, and collecting the current from the beginning of timing to a first preset time point to generate a current value, wherein the current value is the hematocrit background current value of a blood sample to be detected, the voltage application between the counter electrode and the HCT working electrode is stopped at a second preset time interval, and then the voltage application and timing are performed on a second counter electrode, namely: and applying a voltage between the counter electrode and the blood glucose working electrode, wherein the reaction area of the blood glucose test paper generates electrochemical reaction, and collecting the current to generate a current value from the beginning of timing to a second preset time point, wherein the current value is the blood glucose current value of the blood sample to be detected.
The second preset time interval may be determined according to the actual blood glucose measurement accuracy, such as 1 second, 2 seconds, or 3 seconds.
And 103, determining the blood glucose concentration of the blood sample to be detected according to the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test paper.
The compensation coefficient may be a calibration coefficient for calculating the blood glucose concentration of the blood sample to be measured. The compensation factors of different production batches of blood glucose test strips may be the same or different, and the compensation factors of the same production batch of blood glucose test strips may be the same.
It should be understood that different production batches of blood glucose test strips may cause a difference between a hematocrit background current value and a blood glucose current value collected by the same blood glucose test device due to process problems, and a compensation coefficient corresponding to each production batch of blood glucose test strips is generated by testing blood glucose test strips of different production batches, and when a blood glucose test device uses a certain production batch of blood glucose test strips for blood glucose test, the compensation coefficient written in the blood glucose test device corresponds to the compensation coefficient of the blood glucose test strips of the production batch.
As a possible implementation manner, since the hematocrit of blood may affect the blood glucose detection result when performing blood glucose detection, in this embodiment of the present application, the compensation coefficient corresponding to the blood glucose test strip may be predetermined and stored in the blood glucose detection device, and then, when performing blood glucose monitoring, the compensation system corresponding to the blood glucose test strip may be used to correct the background current value of hematocrit and the blood glucose current value, so as to reduce the influence of the hematocrit of blood on the blood glucose detection result, and improve the accuracy of blood glucose detection.
According to the blood glucose detection method provided by the embodiment of the application, a blood sample to be detected is contacted with biological enzymes on a blood glucose test paper, a first preset time point after voltage is applied to a first pair of electrodes is used for collecting a background current value of hematocrit of the blood sample to be detected, and then a second preset time point after voltage is applied to a second pair of electrodes is used for collecting a blood glucose current value of the blood sample to be detected; and then determining the blood glucose concentration of the blood sample to be tested according to the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test paper, so that the blood glucose concentration is converted according to the compensation coefficient corresponding to the blood glucose test paper, the hematocrit background current value and the blood glucose current value, the interference of hematocrit on blood glucose test is obviously reduced, and the accuracy of a blood glucose test result is improved.
In one embodiment, referring to fig. 2, another blood glucose test method is further provided, wherein the compensation factor corresponding to the blood glucose test strip includes: hematocrit compensation factor and blood glucose concentration compensation factor. Referring to fig. 2, a schematic flow chart of another blood glucose detecting method provided in the embodiment of the present application includes:
And 302, acquiring the blood glucose current value of the blood sample to be detected at a second preset time point after the voltage is applied to the second pair of electrodes.
For the specific implementation process and principle of the foregoing steps 301 to 302, reference may be made to the detailed description of the foregoing embodiments, which are not described herein again.
The compensated hematocrit value may be a hematocrit value calibrated by a hematocrit compensation coefficient.
The hematocrit compensation coefficient may be a coefficient related to hematocrit in the blood glucose measurement. The hematocrit compensation factor may include a first hematocrit compensation factor, a second hematocrit compensation factor, a third hematocrit compensation factor, and a fourth hematocrit compensation factor.
As a possible implementation manner, the hematocrit background current value and the blood glucose current value may be input into the hematocrit compensation function, and the compensated hematocrit value may be output. That is, the step 303 may include:
inputting the background current value and the blood glucose current value of the hematocrit into a hematocrit compensation function, and outputting the compensated hematocrit value, wherein the hematocrit compensation function is as follows:
wherein, HCT comp To compensate for the hematocrit value, I HCT Background current value for hematocrit, I w Is the blood glucose current value, K 1 Is the first hematocrit compensation factor, B 1 Compensation factor for the second hematocrit, K 2 Compensation factor for the third hematocrit, B 2 Fourth hematocrit compensation factor.
As a possible implementation, the first hematocrit compensation factor, the second hematocrit compensation factor, the third hematocrit compensation factor, and the fourth hematocrit compensation factor may be determined by:
n x m blood sugar test samples with n blood sugar concentrations and m hematocrit combinations are prepared in advance; obtaining a blood glucose concentration true value, a hematocrit background current test value and a hematocrit value corresponding to the n × m blood glucose test samples, wherein the hematocrit background current test value can be obtained by detecting the n × m blood glucose test samples by adopting blood glucose test paper in the same batch as the blood glucose test paper; determining a first hematocrit compensation coefficient and a second hematocrit compensation coefficient according to a first fitting function of blood glucose concentration real values and hematocrit background current test values corresponding to the nxm blood glucose test samples; and determining a third hematocrit compensation coefficient and a fourth hematocrit compensation coefficient according to the second fitting function of the hematocrit background current test value and the hematocrit value corresponding to the nxm blood glucose test samples.
The blood sugar test sample can be a blood sample required for performing a blood sugar test.
The actual blood glucose concentration value may be a plasma blood glucose concentration value determined by testing n × m blood glucose test samples with a laboratory standard instrument for testing glucose with accuracy up to a preset value. It should be understood that the accuracy of blood glucose detection using the laboratory standard instrument is relatively high, so that the laboratory standard instrument can be used for testing n × m blood glucose test samples to obtain the blood plasma blood glucose concentration value as the true blood glucose concentration value.
The hematocrit background current test value may be a hematocrit background current value obtained by measuring a blood glucose test sample with a blood glucose measuring device using a blood glucose test strip.
The hematocrit value can be a hematocrit value corresponding to the blood sugar test sample, and the hematocrit value is prepared according to the test requirement.
The first fitting function may be a function generated by fitting the real blood glucose concentration values and the hematocrit background current test values corresponding to the nxm blood glucose test samples. As an example, the real values of blood glucose concentration and the background current value of hematocrit corresponding to n × m blood glucose test samples may be input into any fitting function software to generate the first fitting function.
The second fitting function may be a function generated by fitting the hematocrit background current test value and the hematocrit value corresponding to the n × m blood glucose test samples. As an example, the hematocrit background current test value and the hematocrit value corresponding to the n × m blood glucose test samples may be input into the fitting function software to generate the second fitting function.
It should be noted that, in actual use, the fitting function software and the type of the fitting function may be selected according to actual needs and specific application scenarios, which are not limited in real time in the present application. For example, the fitting function software may be an MATLAB, the MATLAB is a tool that can be used for fitting a function, a function type may be arbitrarily selected in the MATLAB, and the function type may be a linear function, a quadratic function, a multi-time function, or the like. In the embodiment of the present application, the first fitting function and the second fitting function may select a linear function, a quadratic function, or a multiple function, which may be determined according to a reaction principle, and the embodiment of the present application does not limit this.
Further, the first hematocrit compensation coefficient may be a coefficient of a highest-order term of the first fitting function; the second hematocrit compensation coefficient may be a constant term of the first fitting function; the third hematocrit compensation coefficient may be a coefficient of a highest-order term of the second fitting function; the fourth hematocrit compensation coefficient may be a constant term of the second fitting function.
As a possible implementation manner, n × m blood glucose test samples of n blood glucose concentrations and m hematocrit combinations, which are respectively expressed as HCT, can be prepared in advance 1-1 、HCT 1-2 、HCT 1-3 ……HCT 1-m 、HCT 2-1 、HCT 2-2 、HCT 2-3 ……HCT 2-m 、HCT n-1 、HCT n-2 、HCT n-3 ……HCT n-m (ii) a The blood plasma glucose concentrations (mg/dL) of the above n × m blood glucose test samples were measured using a laboratory standard instrument and are expressed as: c 1-1 、C 1-2 、C 1-3 ……C 1-m 、C 2-1 、C 2-2 、C 2-3 ……C 2-m 、C n-1 、C n-2 、C n-3 ……C n-m 。
Under normal temperature and normal humidity conditions, adopting a blood glucose measuring device using the blood glucose test paper and the blood glucose test paper of the same production batch to detect n multiplied by m blood glucose test samples to obtain hematocrit background current test values, wherein the hematocrit background current test values of the n multiplied by m blood glucose test samples are as follows: i is HCT1-1 、I HCT1-2 、I HCT1-3 ……I HCT1-m 、I HCT2-1 、I HCT2-2 、I HCT2-3 ……I HCT2-m 、I HCTn-1 、I HCTn-2 、I HCTn-3 ……I HCTn-m 。
As a possible implementation, C may be used 1-1 、C 1-2 、C 1-3 ……C 1-m 、C 2-1 、C 2-2 、C 2-3 ……C 2-m 、C n-1 、C n-2 、C n-3 ……C n-m As the abscissa, I HCT1-1 、I HCT1-2 、I HCT1-3 ……I HCT1-m 、I HCT2-1 、I HCT2-2 、I HCT2-3 ……I HCT2-m 、I HCTn-1 、I HCTn-2 、I HCTn-3 ……I HCTn-m Fitting is performed for the ordinate, a first fitting function is generated, and the coefficient of the highest order term of the first fitting function, which may be a linear function, a quadratic function or more, may be determined as the first hematocrit compensation coefficient K1, and the constant term of the first fitting function may be determined as the second hematocrit compensation coefficient B1.
As a possible implementation, HCT can be used 1-1 、HCT 1-2 、HCT 1-3 ……HCT 1-m 、HCT 2-1 、HCT 2-2 、HCT 2-3 ……HCT 2-m 、HCT n-1 、HCT n-2 、HCT n-3 ……HCT n-m Is the abscissa, I HCT1-1 、I HCT1-2 、I HCT1-3 ……I HCT1-m 、I HCT2-1 、I HCT2-2 、I HCT2-3 ……I HCT2-m 、I HCTn-1 、I HCTn-2 、I HCTn-3 ……I HCTn-m Fitting for the ordinate to generate a second fitting function, the coefficient of the highest-order term of which can be determined as the third hematocrit compensation coefficient K 2 And determining the constant term of the second fitting function as a fourth hematocrit compensation coefficient B 2 The second fitting function may be a linear function, a quadratic function, or a multiple function.
And step 304, determining the blood glucose concentration of the blood sample to be detected according to the compensated hematocrit value, the blood glucose current value and the blood glucose concentration compensation coefficient.
The blood glucose concentration compensation coefficient may be a coefficient related to blood glucose concentration in blood glucose detection. The blood glucose concentration compensation factors include: a first blood glucose concentration compensation factor, a second blood glucose concentration compensation factor, a third blood glucose concentration compensation factor, and a fourth blood glucose concentration compensation factor.
As a possible implementation manner, the compensated hematocrit value and blood glucose current value may be input into the blood glucose concentration compensation function, and the blood glucose concentration of the blood sample to be measured may be output. I.e., step 304, may include:
inputting the compensated hematocrit value and blood glucose current value into a blood glucose concentration compensation function, and outputting the blood glucose concentration of the blood sample to be detected, wherein the blood glucose concentration compensation function is as follows:
wherein, C Glu To determine the blood glucose concentration of the blood sample to be tested, I w As blood glucose current value, HCT comp For compensated hematocrit value, K 3 Compensation factor for first blood glucose concentration, B 3 Compensation factor for second blood glucose concentration, K 4 Compensation factor for third blood glucose concentration, B 4 A fourth blood glucose concentration compensation factor.
As a possible implementation, the first, second, third and fourth blood glucose concentration compensation factors may be determined by: n x m blood sugar test samples with n blood sugar concentrations and m hematocrit combinations are prepared in advance; obtaining real values of blood glucose concentration, blood glucose and current test values and hematocrit values corresponding to the n x m blood glucose test samples, wherein the blood glucose and current test values are obtained by detecting the n x m blood glucose test samples by adopting blood glucose test paper in the same batch as the blood glucose test paper; determining a first blood glucose concentration compensation coefficient and a second blood glucose concentration compensation coefficient according to a third fitting function of the blood glucose concentration true values and the blood glucose current test values corresponding to the nxm blood glucose test samples; and determining a third blood glucose concentration compensation coefficient and a fourth blood glucose concentration compensation coefficient according to a fourth fitting function of the blood glucose current test value and the hematocrit value corresponding to the n x m blood glucose test samples.
The blood glucose current test value may be obtained by measuring a blood glucose test sample with a blood glucose measuring device using blood glucose test paper.
The hematocrit value can be a hematocrit value corresponding to the blood sugar test sample, and the hematocrit value is prepared according to the test requirement.
The third fitting function may be a function generated by fitting the real blood glucose concentration values and the blood glucose current test values corresponding to the nxm blood glucose test samples. As an example, the true blood glucose concentration values and blood glucose current test values corresponding to n × m blood glucose test samples may be input into any fitting function software to generate the third fitting function.
The fourth fitting function may be a function generated by fitting blood glucose current test values and hematocrit values corresponding to the n × m blood glucose test samples. As an example, the blood glucose current test values and the hematocrit values corresponding to the n × m blood glucose test samples may be input into the fitting function software to generate the fourth fitting function.
It should be noted that, in actual use, the fitting function software and the type of the fitting function may be selected according to actual needs and specific application scenarios, which are not limited in real time in the present application. For example, the fitting function software may be an MATLAB, the MATLAB is a tool that can be used for fitting a function, a function type may be arbitrarily selected in the MATLAB, and the function type may be a linear function, a quadratic function, a multi-time function, or the like. In the embodiment of the present application, the first fitting function and the second fitting function may be a linear function, a quadratic function, or a multi-time function, which may be determined according to a reaction principle, and the embodiment of the present application does not limit this.
Further, the first blood glucose concentration compensation coefficient may be a coefficient of a highest-order term of the third fitting function; the second blood glucose concentration compensation factor may be a constant term of the third fitting function; the third blood glucose concentration compensation factor may be a factor of a highest-order term of the fourth fitting function; the fourth blood glucose concentration compensation factor may be a constant term of the fourth fitting function.
As one possible implementation manner, n × m blood glucose test samples of n blood glucose concentrations and m hematocrit combinations can be prepared in advance, and the n × m blood glucose test samples are respectively represented as HCT 1-1 、HCT 1-2 、HCT 1-3 ……HCT 1-m 、HCT 2-1 、HCT 2-2 、HCT 2-3 ……HCT 2-m 、HCT n-1 、HCT n-2 、HCT n-3 ……HCT n-m (ii) a The blood plasma glucose concentrations (mg/dL) of the above n × m blood glucose test samples were measured using a laboratory standard instrument and are expressed as: c 1-1 、C 1-2 、C 1-3 ……C 1-m 、C 2-1 、C 2-2 、C 2-3 ……C 2-m 、C n-1 、C n-2 、C n-3 ……C n-m 。
Detecting n x m blood glucose test samples by adopting blood glucose measuring equipment using the blood glucose test strips and the blood glucose test strips of the same production batch under the normal temperature and the normal humidity condition to obtain blood glucose current test values, wherein the blood glucose current test values of the n x m blood glucose test samples are represented as I W1-1 、I W1-2 、I W1-3 ……I W1-m 、I W2-1 、I W2-2 、I W2-3 ……I W2-m 、I Wn-1 、I Wn-2 、I Wn-3 ……I Wn-m 。
As a possible implementation, C may be used 1-1 、C 1-2 、C 1-3 ……C 1-m 、C 2-1 、C 2-2 、C 2-3 ……C 2-m 、C n-1 、C n-2 、C n-3 ……C n-m As the abscissa, I W1-1 、I W1-2 、I W1-3 ……I W1-m 、I W2-1 、I W2-2 、I W2-3 ……I W2-m 、I Wn-1 、I Wn-2 、I Wn-3 ……I Wn-m Fitting is performed for the ordinate to generate a third fitting function, and the coefficient of the highest order term of the third fitting function can be determined as the first blood glucose concentration compensation coefficient K 3 And determining a constant term of the third fitting function as a second blood glucose concentration compensation coefficient B 3 The third fitting function may be a linear function, a quadratic function, or a multi-order function.
As a possible implementation, HCT may be used 1-1 、HCT 1-2 、HCT 1-3 ……HCT 1-m 、HCT 2-1 、HCT 2-2 、HCT 2-3 ……HCT 2-m 、HCT n-1 、HCT n-2 、HCT n-3 ……HCT n-m As the abscissa, I W1-1 、I W1-2 、I W1-3 ……I W1-m 、I W2-1 、I W2-2 、I W2-3 ……I W2-m 、I Wn-1 、I Wn-2 、I Wn-3 ……I Wn-m Fitting is carried out for the ordinate to generate a fourth fitting function, and the coefficient of the highest-order term of the fourth fitting function can be determined as the third blood glucose concentration compensation coefficient K 4 And determining a constant term of the fourth fitting function as a fourth blood glucose concentration compensation coefficient B 4 The fourth fitting function may be a linear function, a quadratic function, or a multiple function.
According to the blood sugar detection method provided by the embodiment of the application, a blood sample to be detected is contacted with biological enzyme on blood sugar test paper, the blood sugar current of the blood sample to be detected is acquired at a first preset time point after voltage is applied to a first pair of electrodes by acquiring the hematocrit background current value of the blood sample to be detected, and then the blood sugar current of the blood sample to be detected is acquired at a second preset time point after voltage is applied to a second pair of electrodes; determining a compensated hematocrit value according to the hematocrit background current value, the blood glucose current value and the hematocrit compensation coefficient; and determining the blood glucose concentration of the blood sample to be detected according to the compensated hematocrit value, the blood glucose current value and the blood glucose concentration compensation coefficient. Therefore, the influence of the hematocrit on the blood glucose concentration is quantified through the hematocrit background current value, the blood glucose current value and the hematocrit compensation coefficient to obtain a compensated hematocrit value, and the blood glucose current value is corrected according to the compensated hematocrit value and the blood glucose concentration compensation coefficient to obtain the blood glucose concentration of the blood sample to be tested, so that the interference of the hematocrit on the blood glucose test is further remarkably reduced, and the accuracy of the blood glucose test result is improved.
To further clearly demonstrate the beneficial effects of the present application, experimental tests were performed on 30 blood glucose test samples formulated with 6 blood glucose concentrations and 5 hematocrit combinations, namely: n =6,m =5, as follows:
and (3) testing 30 blood sugar test samples by using a laboratory standard instrument, and testing the actual blood sugar concentration values of the 30 obtained blood sugar test samples, wherein the actual blood sugar concentration values are shown in tables 1 to 5.
Under the conditions of normal temperature and normal humidity, 30 blood glucose test samples are tested by adopting a blood glucose measuring device using the blood glucose test paper and the blood glucose test paper of the same production batch to respectively obtain the background current value I of hematocrit HCT And blood glucose current value I W See tables 1 and 2, where each blood glucose test sample was tested 5 times in parallel:
table 1: hematocrit background current value I corresponding to 30 blood sugar test samples HCT And average value table
Table 2: blood glucose current value I corresponding to 30 blood glucose test samples W And average value table
According to the background current value of hematocrit corresponding to the 30 blood glucose test samples in table 1 and the blood glucose current value corresponding to the 30 blood glucose test samples in table 2, the compensated hematocrit value calculated by the hematocrit compensation function is adopted, and the hematocrit compensation coefficient in the hematocrit compensation function is the hematocrit compensation coefficient corresponding to the blood glucose test strip of the production batch, which is shown in table 3:
table 3: compensated hematocrit value table corresponding to 30 blood sugar test samples
According to the hematocrit background current values corresponding to the 30 blood glucose test samples in table 1, the blood glucose current values corresponding to the 30 blood glucose test samples in table 2 and the compensated hematocrit values corresponding to the 30 blood glucose test samples in table 3, the blood glucose concentration is calculated through the blood glucose concentration compensation function, and the blood glucose concentration compensation coefficient in the blood glucose concentration compensation function is the blood glucose concentration compensation coefficient corresponding to the blood glucose test paper of the production batch, see table 4:
table 4: blood glucose concentration and average value table corresponding to 30 blood glucose test samples
Through the table 4, it can be seen that the blood glucose current value is corrected according to the compensated hematocrit value and the blood glucose concentration compensation coefficient, the error between the obtained blood glucose concentration and the true blood glucose concentration value is within the blood glucose measurement error standard in the field, and the error is small, so that the blood glucose detection method improves the accuracy of the blood glucose test result.
It should be understood that although the various steps in the flowcharts of fig. 1-2 are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and described, and may be performed in other orders, unless explicitly stated otherwise. Moreover, at least some of the steps in fig. 1-2 may include multiple steps or multiple stages, which are not necessarily performed at the same time, but may be performed at different times, and the order of performing the steps or stages is not necessarily sequential, but may be performed alternately or alternately with other steps or at least some of the steps or stages in other steps.
In one embodiment, as shown in fig. 3, a blood glucose detecting apparatus is provided, which may be a part of a computer device using a software module or a hardware module, or a combination of the two modules, and specifically includes: a first acquisition module 410, a second acquisition module 420, and a detection module 430.
The first collecting module 410 is configured to collect a background current value of hematocrit of the blood sample to be detected at a first preset time point after the blood sample to be detected contacts the bio-enzyme on the blood glucose test strip and the voltage is applied to the first pair of electrodes.
The second collecting module 420 is configured to collect a blood glucose value of the blood sample to be measured at a second preset time point after the voltage is applied to the second pair of electrodes.
And the detection module 430 is configured to determine the blood glucose concentration of the blood sample to be detected according to the hematocrit background current value, the blood glucose current value, and the compensation coefficient corresponding to the blood glucose test paper.
According to the blood glucose detection device provided by the embodiment of the application, a blood sample to be detected is contacted with biological enzymes on a blood glucose test paper, a first preset time point after voltage is applied to a first pair of electrodes is used for collecting a background current value of hematocrit of the blood sample to be detected, and then a second preset time point after voltage is applied to a second pair of electrodes is used for collecting a blood glucose current value of the blood sample to be detected; and determining the blood glucose concentration of the blood sample to be tested according to the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test paper, so that the blood glucose concentration is converted according to the compensation coefficient corresponding to the blood glucose test paper, the hematocrit background current value and the blood glucose current value, the interference of the hematocrit on the blood glucose test is obviously reduced, and the accuracy of the blood glucose test result is improved.
In one embodiment, the compensation factors for the blood glucose test strip include: the hematocrit compensation factor and the blood glucose concentration compensation factor, the detection module 430 is further configured to: determining a compensated hematocrit value according to the hematocrit background current value, the blood glucose current value and the hematocrit compensation coefficient; and determining the blood glucose concentration of the blood sample to be detected according to the compensated hematocrit value, the blood glucose current value and the blood glucose concentration compensation coefficient.
In one embodiment, the hematocrit compensation factor comprises: the first hematocrit compensation factor, the second hematocrit compensation factor, the third hematocrit compensation factor, and the fourth hematocrit compensation factor, the detection module 430 is further configured to: inputting the background current value of hematocrit and the blood glucose current value into a hematocrit compensation function, and outputting the compensated hematocrit value, wherein the hematocrit compensation function is as follows:
wherein, HCT comp To compensate for the hematocrit value, I HCT Background current value for hematocrit, I w Is the blood glucose current value, K 1 Compensation factor for first hematocrit, B 1 Compensation factor for the second hematocrit, K 2 Compensation factor for the third hematocrit, B 2 Fourth hematocrit compensation factor.
In one embodiment, the hematocrit compensation factor is determined by: n x m blood sugar test samples with n blood sugar concentrations and m hematocrit combinations are prepared in advance; acquiring real values of blood glucose concentration, hematocrit background current test values and hematocrit values corresponding to the n x m blood glucose test samples, wherein the hematocrit background current test values are obtained by detecting the n x m blood glucose test samples by adopting blood glucose test paper in the same batch as the blood glucose test paper; determining a first hematocrit compensation coefficient and a second hematocrit compensation coefficient according to a first fitting function of blood glucose concentration real values and hematocrit background current test values corresponding to the nxm blood glucose test samples; and determining a third hematocrit compensation coefficient and a fourth hematocrit compensation coefficient according to the second fitting function of the hematocrit background current test value and the hematocrit value corresponding to the nxm blood glucose test samples.
In one embodiment, the first hematocrit compensation coefficient is the coefficient of the highest order term of the first fitting function; the second hematocrit compensation coefficient is a constant term of the first fitting function; the third hematocrit compensation coefficient is a coefficient of a highest-order term of the second fitting function; the fourth hematocrit compensation coefficient is a constant term of the second fitting function.
In one embodiment, the blood glucose concentration compensation factor comprises: the first, second, third and fourth blood glucose concentration compensation coefficients, the detection module 430 is further configured to: inputting the compensated hematocrit value and blood glucose current value into a blood glucose concentration compensation function, and outputting the blood glucose concentration of the blood sample to be detected, wherein the blood glucose concentration compensation function is as follows:
wherein, C Glu Blood glucose concentration of the blood sample to be tested, I w As blood glucose current value, HCT comp For compensated hematocrit, K 3 Compensation factor for first blood glucose concentration, B 3 Is a second blood glucose concentration compensation factor, K 4 Compensation factor for third blood glucose concentration, B 4 A fourth blood glucose concentration compensation factor.
In one embodiment, the blood glucose concentration compensation factor is determined by: n x m blood sugar test samples with n blood sugar concentrations and m hematocrit combinations are prepared in advance; obtaining real values of blood glucose concentration, blood glucose and current test values and hematocrit values corresponding to the n x m blood glucose test samples, wherein the blood glucose and current test values are obtained by detecting the n x m blood glucose test samples by adopting blood glucose test paper in the same batch as the blood glucose test paper; determining a first blood glucose concentration compensation coefficient and a second blood glucose concentration compensation coefficient according to a third fitting function of the blood glucose concentration true values and the blood glucose current test values corresponding to the nxm blood glucose test samples; and determining a third blood glucose concentration compensation coefficient and a fourth blood glucose concentration compensation coefficient according to a fourth fitting function of the blood glucose current test value and the hematocrit value corresponding to the n x m blood glucose test samples.
In one embodiment, the first blood glucose concentration compensation factor is a factor of a highest order term of the third fitting function; the second blood glucose concentration compensation coefficient is a constant term of the third fitting function; the third blood glucose concentration compensation coefficient is the coefficient of the highest-order term of the fourth fitting function; the fourth glucose concentration compensation factor is a constant term of the fourth fitting function.
According to the blood sugar detection device provided by the embodiment of the application, through the contact between a blood sample to be detected and biological enzymes on blood sugar test paper, the blood sugar current of the blood sample to be detected is acquired at a first preset time point after the voltage is applied to a first pair of electrodes by acquiring the hematocrit background current value of the blood sample to be detected and then at a second preset time point after the voltage is applied to a second pair of electrodes; determining a compensated hematocrit value according to the hematocrit background current value, the blood glucose current value and the hematocrit compensation coefficient; and determining the blood glucose concentration of the blood sample to be detected according to the compensated hematocrit value, the blood glucose current value and the blood glucose concentration compensation coefficient. Therefore, the influence of the hematocrit on the blood glucose concentration is quantified through the hematocrit background current value, the blood glucose current value and the hematocrit compensation coefficient to obtain a compensated hematocrit value, and the blood glucose current value is corrected according to the compensated hematocrit value and the blood glucose compensation coefficient to obtain the blood glucose concentration of the blood sample to be tested, so that the interference of the hematocrit on the blood glucose test in the blood is further remarkably reduced, and the accuracy of the blood glucose test result is improved.
For the specific definition of the blood glucose testing device, reference may be made to the definition of the blood glucose testing method above, and details are not repeated here. The modules in the blood sugar detecting device can be wholly or partially realized by software, hardware and a combination thereof. The modules can be embedded in a hardware form or independent of a processor in the computer device, and can also be stored in a memory in the computer device in a software form, so that the processor can call and execute operations corresponding to the modules.
FIG. 4 is a schematic structural diagram of a blood glucose test device provided by the present application in one embodiment. As shown in fig. 4, the blood glucose detecting apparatus 700 of this embodiment includes: at least one processor 710 (only one shown in fig. 4), a memory 720, and a computer program 721 stored in the memory 720 and operable on the at least one processor 710, the steps in the above-described blood glucose detection method embodiments being implemented when the computer program 721 is executed by the processor 710.
The blood glucose detecting device 700 may be a device for detecting blood glucose, such as a desktop computer, a notebook, a blood glucose meter, a palm computer, and a cloud server. The blood glucose measuring device may include, but is not limited to, a processor 710, a memory 720. Those skilled in the art will appreciate that FIG. 4 is merely an example of a blood glucose sensing device 700 and does not constitute a limitation of the blood glucose sensing device 700, and may include more or fewer components than shown, or some components in combination, or different components, such as input-output devices, network access devices, etc.
The Processor 710 may be a Central Processing Unit (CPU), and the Processor 710 may be other general purpose Processor, a Digital Signal Processor (DSP), an Application Specific Integrated Circuit (ASIC), an off-the-shelf Programmable Gate Array (FPGA) or other Programmable logic device, discrete Gate or transistor logic, discrete hardware components, etc. A general purpose processor may be a microprocessor or the processor may be any conventional processor or the like.
The memory 720 may be an internal storage unit of the blood glucose testing device 700 in some embodiments, such as a hard disk or memory of the blood glucose testing device 700. The memory 720 may also be an external storage device of the blood glucose detecting device 700 in other embodiments, such as a plug-in hard disk provided on the blood glucose detecting device 700, a Smart Media Card (SMC), a Secure Digital (SD) Card, a Flash memory Card (Flash Card), and so on. Further, memory 720 may also include both internal and external memory units of blood glucose testing device 700. The memory 720 is used for storing an operating system, an application program, a Boot Loader (Boot Loader), data, and other programs, such as program codes of a computer program. The memory 720 may also be used to temporarily store data that has been output or is to be output.
It should be clear to those skilled in the art that, for convenience and simplicity of description, the foregoing division of the functional units and modules is only used for illustration, and in practical applications, the above function distribution may be performed by different functional units and modules as needed, that is, the internal structure of the device is divided into different functional units or modules, so as to perform all or part of the above described functions. Each functional unit and module in the embodiments may be integrated in one processing unit, or each unit may exist alone physically, or two or more units are integrated in one unit, and the integrated unit may be implemented in a form of hardware, or in a form of software functional unit. In addition, specific names of the functional units and modules are only for convenience of distinguishing from each other, and are not used for limiting the protection scope of the present application. The specific working processes of the units and modules in the system may refer to the corresponding processes in the foregoing method embodiments, and are not described herein again.
In the above embodiments, the descriptions of the respective embodiments have respective emphasis, and reference may be made to the related descriptions of other embodiments for parts that are not described or illustrated in a certain embodiment.
Those of ordinary skill in the art will appreciate that the various illustrative elements and algorithm steps described in connection with the embodiments disclosed herein may be implemented as electronic hardware or combinations of computer software and electronic hardware. Whether such functionality is implemented as hardware or software depends upon the particular application and design constraints imposed on the implementation. Skilled artisans may implement the described functionality in varying ways for each particular application, but such implementation decisions should not be interpreted as causing a departure from the scope of the present application.
In the embodiments provided in the present application, it should be understood that the disclosed apparatus/blood glucose detecting device and method may be implemented in other ways. For example, the above-described device/blood glucose detection apparatus embodiments are merely illustrative, and for example, the division of the modules or units is only one logical division, and other divisions may be realized in practice, for example, a plurality of units or components may be combined or integrated into another system, or some features may be omitted, or not executed. In addition, the shown or discussed mutual coupling or direct coupling or communication connection may be an indirect coupling or communication connection through some interfaces, devices or units, and may be in an electrical, mechanical or other form.
The units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of the embodiment.
In addition, functional units in the embodiments of the present application may be integrated into one processing unit, or each unit may exist alone physically, or two or more units are integrated into one unit. The integrated unit may be implemented in the form of hardware, or may also be implemented in the form of a software functional unit.
The integrated modules/units, if implemented in the form of software functional units and sold or used as separate products, may be stored in a computer readable storage medium. Based on such understanding, all or part of the flow in the method of the embodiments described above can be realized by a computer program, which can be stored in a computer-readable storage medium and can realize the steps of the embodiments of the methods described above when the computer program is executed by a processor. Wherein the computer program comprises computer program code, which may be in the form of source code, object code, an executable file or some intermediate form, etc. The computer-readable medium may include: any entity or device capable of carrying the computer program code, recording medium, usb disk, removable hard disk, magnetic disk, optical disk, computer Memory, read-Only Memory (ROM), random Access Memory (RAM), electrical carrier wave signals, telecommunications signals, software distribution medium, and the like. It should be noted that the computer readable medium may contain content that is subject to appropriate increase or decrease as required by legislation and patent practice in jurisdictions, for example, in some jurisdictions, computer readable media does not include electrical carrier signals and telecommunications signals as is required by legislation and patent practice.
The present application may also be implemented by a computer program product, when the computer program product runs on a blood glucose detecting device, the steps in the above method embodiments may be implemented when the blood glucose detecting device executes the computer program product.
The above-mentioned embodiments are only used for illustrating the technical solutions of the present application, and not for limiting the same. Although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not substantially depart from the spirit and scope of the embodiments of the present application and are intended to be included within the scope of the present application.
Claims (10)
1. A method of blood glucose testing, comprising:
collecting the background current value of the hematocrit of the blood sample to be detected at a first preset time point after the blood sample to be detected is contacted with the biological enzyme on the blood glucose test paper and the voltage is applied to the first pair of electrodes;
collecting the blood glucose current value of the blood sample to be detected at a second preset time point after the voltage is applied to the second pair of electrodes;
and determining the blood glucose concentration of the blood sample to be detected according to the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test paper.
2. The method of claim 1, wherein the compensation factor for the blood glucose strip comprises: the determining the blood glucose concentration of the blood sample to be tested according to the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test paper comprises the following steps:
determining a compensated hematocrit value according to the hematocrit background current value, the blood glucose current value and the hematocrit compensation coefficient;
and determining the blood glucose concentration of the blood sample to be detected according to the compensated hematocrit value, the blood glucose current value and the blood glucose concentration compensation coefficient.
3. The method of claim 2, wherein the hematocrit compensation factor comprises: the method for determining the compensated hematocrit value according to the background hematocrit current value, the blood glucose current value and the hematocrit compensation coefficient includes:
inputting the background current value of hematocrit and the blood glucose current value into a hematocrit compensation function, and outputting the compensated hematocrit value, wherein the hematocrit compensation function is as follows:
wherein, HCT comp Is the compensated hematocrit value, I HCT As the hematocrit background current value, I w Is the blood glucose current value, K 1 Compensation factor for said first hematocrit, B 1 Compensation factor for the second hematocrit, K 2 For the third hematocrit compensation factor, B 2 The fourth hematocrit compensation factor.
4. The method of claim 3, wherein the hematocrit compensation factor is determined by:
n x m blood sugar test samples with n blood sugar concentrations and m hematocrit combinations are prepared in advance;
obtaining a blood glucose concentration true value, a hematocrit background current test value and a hematocrit value corresponding to the n × m blood glucose test samples, wherein the hematocrit background current test value is obtained by detecting the n × m blood glucose test samples by adopting blood glucose test paper in the same batch as the blood glucose test paper;
determining the first hematocrit compensation coefficient and the second hematocrit compensation coefficient according to a first fitting function of the blood glucose concentration real values and the hematocrit background current test values corresponding to the n × m blood glucose test samples;
and determining the third hematocrit compensation coefficient and the fourth hematocrit compensation coefficient according to a second fitting function of the hematocrit background current test value and the hematocrit value corresponding to the n × m blood glucose test samples.
5. The method of claim 4, wherein the first hematocrit compensation coefficient is a coefficient of a highest-order term of the first fitting function; the second hematocrit compensation coefficient is a constant term of the first fitting function; the third hematocrit compensation coefficient is a coefficient of a highest-order term of the second fitting function; the fourth hematocrit compensation coefficient is a constant term of the second fitting function.
6. The blood glucose test method of any one of claims 2-5, wherein the blood glucose concentration compensation factor comprises: the method comprises the following steps of determining the blood glucose concentration of a blood sample to be detected according to the compensated hematocrit value, the blood glucose current value and the blood glucose concentration compensation coefficient, wherein the first blood glucose concentration compensation coefficient, the second blood glucose concentration compensation coefficient, the third blood glucose concentration compensation coefficient and the fourth blood glucose concentration compensation coefficient comprise the following steps:
inputting the compensated hematocrit value and the blood glucose current value into a blood glucose concentration compensation function, and outputting the blood glucose concentration of the blood sample to be detected, wherein the blood glucose concentration compensation function is as follows:
wherein, C Glu Is the blood glucose concentration of the blood sample to be tested, I w For the blood glucose current value, HCT comp As said compensated hematocrit value, K 3 Compensating for the first blood glucose concentration by a factor, B 3 Is the second blood glucose concentration compensation factor, K 4 Compensating for the third blood glucose concentration factor, B 4 Compensating for the fourth glucose concentration compensation factor.
7. The blood glucose test method of claim 6, wherein the blood glucose concentration compensation factor is determined by:
n x m blood sugar test samples with n blood sugar concentrations and m hematocrit combinations are prepared in advance;
obtaining real values of blood glucose concentration, blood glucose current test values and hematocrit values corresponding to the n x m blood glucose test samples, wherein the blood glucose current test values are obtained by detecting the n x m blood glucose test samples by adopting blood glucose test strips in the same batch as the blood glucose test strips;
determining the first blood glucose concentration compensation coefficient and the second blood glucose concentration compensation coefficient according to a third fitting function of the blood glucose concentration real value and the blood glucose current test value corresponding to the n x m blood glucose test samples;
and determining the third blood glucose concentration compensation coefficient and the fourth blood glucose concentration compensation coefficient according to a fourth fitting function of the blood glucose current test value and the hematocrit value corresponding to the n x m blood glucose test samples.
8. The method of claim 7, wherein the first glucose concentration compensation factor is a factor of a highest-order term of the third fitting function; the second blood glucose concentration compensation coefficient is a constant term of the third fitting function; the third blood glucose concentration compensation coefficient is a coefficient of a highest-order term of the fourth fitting function; the fourth blood glucose concentration compensation factor is a constant term of the fourth fitting function.
9. A blood glucose test device, comprising:
the first acquisition module is used for acquiring a background current value of hematocrit of a blood sample to be detected at a first preset time point after the blood sample to be detected is contacted with biological enzyme on the blood glucose test paper and voltage is applied to the first pair of electrodes;
the second collection module is used for collecting the blood glucose current value of the blood sample to be detected at a second preset time point after the voltage is applied to the second pair of electrodes;
and the detection module is used for determining the blood glucose concentration of the blood sample to be detected according to the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test paper.
10. A blood glucose monitoring device comprising a memory, a processor and a computer program stored in the memory and executable on the processor, characterized in that the processor implements the method of any one of claims 1 to 8 when executing the computer program.
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