CN115429341B - In-situ real-time biopsy needle, device and system based on OCT (optical coherence tomography) - Google Patents
In-situ real-time biopsy needle, device and system based on OCT (optical coherence tomography) Download PDFInfo
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- CN115429341B CN115429341B CN202211198281.7A CN202211198281A CN115429341B CN 115429341 B CN115429341 B CN 115429341B CN 202211198281 A CN202211198281 A CN 202211198281A CN 115429341 B CN115429341 B CN 115429341B
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- 238000001574 biopsy Methods 0.000 title claims abstract description 56
- 238000011065 in-situ storage Methods 0.000 title claims abstract description 39
- 238000012014 optical coherence tomography Methods 0.000 title abstract description 31
- 239000013307 optical fiber Substances 0.000 claims abstract description 77
- 230000001575 pathological effect Effects 0.000 claims abstract description 19
- 230000001681 protective effect Effects 0.000 claims description 29
- 230000003287 optical effect Effects 0.000 claims description 26
- 239000002184 metal Substances 0.000 claims description 21
- 238000001514 detection method Methods 0.000 claims description 14
- 238000004891 communication Methods 0.000 claims description 9
- 239000006185 dispersion Substances 0.000 claims description 7
- 230000005389 magnetism Effects 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 239000007769 metal material Substances 0.000 claims description 4
- 238000005070 sampling Methods 0.000 claims description 4
- 239000000835 fiber Substances 0.000 claims description 3
- 238000005259 measurement Methods 0.000 claims description 3
- 230000003902 lesion Effects 0.000 description 8
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
Abstract
The invention provides an in-situ real-time biopsy needle, a device and a system based on OCT, wherein after the biopsy needle is inserted into pathological tissues, a motor transmits torque through a torque coil to drive a first optical fiber, a collimating lens, a focusing lens, a reflecting mirror and a fixing piece to rotate simultaneously, and the first optical fiber emits laser to be emitted to the pathological tissues after passing through the collimating lens, the focusing lens and the reflecting mirror, and scans the pathological tissues through a perspective window for 360 degrees to obtain pathological information of the pathological tissues; the invention realizes in-situ biopsy of living body by utilizing Optical Coherence Tomography (OCT), and improves biopsy efficiency while ensuring biopsy accuracy.
Description
Technical Field
The invention relates to the technical field of in-situ biopsy medical equipment, in particular to an in-situ real-time biopsy needle, device and system of a living body based on OCT.
Background
The statements in this section merely provide background information related to the present disclosure and may not necessarily constitute prior art.
Biopsy is a technique for taking out pathological tissue from a patient body by incision, forceps or puncture and the like according to the requirements of diagnosis and treatment, and the main purpose of the biopsy is as follows: assisting in diagnosing lesions or providing clues for diagnosing diseases in clinic; knowing the nature and development trend of the lesions, and judging the prognosis of the diseases; verifying and observing the curative effect of the medicine, and providing reference basis for clinical medication; the method is involved in clinical scientific research, and new diseases or new types are discovered, so that pathological histology basis is provided for clinical scientific research.
The histopathological diagnostic procedure of a biopsy is generally: visual inspection of the sample, sampling, fixing, embedding, preparing thin sections, hematoxylin-eosin (HE) staining, and observing under an optical microscope; through analysis and identification of pathological tissue and cell morphology, and combination of macroscopic observation and clinical related data, diagnosis of various diseases is made.
The inventor finds that on the basis of the conventional examination, the auxiliary diagnosis is carried out by using techniques such as histochemistry, immunohistochemistry, electron microscope or molecular biology and the like on some difficult and rare cases, so that great wounds are caused to patients; meanwhile, the existing detection method has the problem of inaccurate detection of a lesion area, so that lesion tissues are not thoroughly removed, and subsequent complications are easy to generate.
Disclosure of Invention
In order to solve the defects in the prior art, the invention provides an in-situ real-time biopsy needle, a device and a system of a living body based on OCT, which utilize Optical Coherence Tomography (OCT) to realize real-time in-situ biopsy of the living body and improve biopsy efficiency while ensuring biopsy accuracy.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
the first aspect of the invention provides an OCT-based in-situ real-time biopsy needle.
An OCT-based in-situ real-time biopsy needle, comprising:
a first optical fiber, a protective sleeve, a moment coil, a collimating lens, a focusing lens, a reflecting mirror, a fixing piece and a metal shell, the first optical fiber is nested in the protective sleeve, and the moment coil is fixed on the inner side wall of the protective sleeve or embedded in the wall of the protective sleeve;
the first end of the first optical fiber is used for receiving detection light or sending scattered light, the collimating lens, the focusing lens and the reflecting mirror are sequentially arranged in the hollow structure of the fixing piece along the light path, the first opening end of the fixing piece extends into the protective sleeve and is fixedly connected with the inner wall of the protective sleeve, and the second end of the first optical fiber is opposite to the collimating lens along the light path;
the position cover that is close to first optic fibre first end in the protective sheath outside is equipped with fixed cover, and fixed cover outside cover is equipped with the magnetism ring, and magnetism ring is connected with the inside wall of metal casing first end, and the lateral part of mounting is opened to have the second opening relative along the light path position with the speculum, and the metal casing is equipped with perspective window with the relative position of speculum, and metal casing second end inboard is fixed with magnetic element, and mounting and fixed cover are the metal material.
As an alternative implementation, the perspective window is a continuous annular window or an intermittent annular window.
As an alternative implementation, the magnetic element is disposed at the bottom inside the second end of the metal casing.
As an optional implementation manner, the outgoing direction of the detection light of the reflection environment is perpendicular to the central axis of the metal shell; or the emergent direction of the detection light of the reflection environment is perpendicular to the central axis of the protective sleeve.
The second aspect of the invention provides an in-situ real-time biopsy device for living body based on OCT.
An OCT-based in-situ real-time biopsy device, comprising: the motor, the belt pulley, the second optical fiber and the in-situ real-time biopsy needle based on OCT according to the first aspect of the invention;
the motor is connected with the belt pulley through a belt, a hollow shaft of the belt pulley is connected with a protective sleeve at the first end position of the first optical fiber, the second end of the second optical fiber is opposite to one side of the collimating component along the optical path, and the other side of the collimating component is opposite to the first end of the first optical fiber along the optical path.
As an alternative implementation manner, the second end of the second optical fiber is fixedly connected with the supporting component, and the supporting component and the motor are both fixed on the supporting base.
A third aspect of the invention provides an OCT-based in-situ real-time biopsy system.
An OCT-based in-situ real-time biopsy system, comprising: the device comprises a light source, an optical coupler, a spectrometer, a collimator, a dispersion module, an attenuation module, a plane mirror and the in-situ real-time living body biopsy device based on OCT according to the second aspect of the invention;
the light source and the spectrometer are respectively connected with the first end (i.e. left end) of the optical coupler through optical fibers, the second end (i.e. right end) of the optical coupler is connected with the first end of the second optical fiber, the second end of the optical coupler is connected with one side of the collimator through optical fibers, and the other side of the collimator is sequentially provided with a dispersion module, an attenuation module and a plane reflector along the light path.
As an alternative implementation manner, the motor is in communication connection with the control terminal; or, the motor is connected with a microcontroller, and the microcontroller is connected with a control terminal.
As an alternative implementation manner, the spectrometer is in communication connection with the control terminal; alternatively, the spectrometer is in communication connection with an image processing terminal, which is in communication connection with a control terminal.
As an optional implementation manner, after the biopsy needle is inserted into the pathological tissue, the motor transmits torque through the torque coil to drive the first optical fiber, the collimating lens, the focusing lens, the reflecting mirror and the fixing piece to rotate simultaneously, and the first optical fiber emits laser to exit to the pathological tissue after passing through the collimating lens, the focusing lens and the reflecting mirror, and 360-degree scanning is performed on the pathological tissue through the perspective window to acquire pathological information of the pathological tissue;
the reference light reflected by the plane reflector and the back scattered light of the measured sample are converged on the spectrometer, and interference occurs when the optical path difference between the reference light and the back scattered light is within the coherence length of the light source;
and scanning the plane reflector and recording the space position, so that the reference light interferes with the backward scattered light from different Z-direction depths, obtaining measurement data of different sample depths according to the position of the plane reflector and the corresponding interference signal intensity, and obtaining the three-dimensional structure information of the sample by combining the scanning result of the sampling light beam in the XY plane.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the in-situ real-time biopsy needle, the device and the system based on the OCT, the free end of the first optical fiber is arranged in the needle-shaped metal shell by utilizing Optical Coherence Tomography (OCT), so that an optical detection part can be more efficiently sent into a tissue to be detected, real-time in-situ biopsy of the living body is realized, and the biopsy efficiency is improved while the biopsy accuracy is ensured.
2. In the invention, the first optical fiber is wrapped by the protective sleeve and the moment coil, wherein one fixed end (the end close to the motor belt pulley) is connected with the collimating component, the other end (namely the free end) is connected with the collimating lens, the focusing lens, the reflecting mirror and the fixing piece, the components are integrated, the belt pulley drives the whole body to rotate, the moment coil bears the moment transmitted by the belt pulley, and the damage to the optical fiber caused by the moment is effectively prevented.
3. In the invention, the fixing piece and the fixing sleeve are made of metal materials, the positions of the needle tip and the needle tail of the biopsy needle are respectively provided with the magnet block and the magnet ring, the axial freedom and the radial freedom of the free end of the first optical fiber are limited by magnetism, and the rotation freedom of the first optical fiber is not influenced.
4. In the invention, the first optical fiber is connected with the hollow shaft of the belt wheel, a tiny gap is reserved between the two opposite ends of the first optical fiber and the second optical fiber, after the calibration of the collimating component, the laser emitted by the light source can be incident into the first optical fiber through the second optical fiber, the second optical fiber is fixed on the supporting component and is relatively static to the motor, and the first optical fiber is fixed on the hollow shaft and is a fixed end and is relatively static to the belt wheel, so that 360-degree rotation detection is realized.
Additional aspects of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention.
Fig. 1 is a schematic structural diagram of an OCT-based in-situ real-time biopsy needle according to embodiment 1 of the present invention.
Fig. 2 is a schematic diagram of a motor part of an OCT-based in-situ real-time biopsy device according to embodiment 2 of the present invention.
Fig. 3 is a schematic connection diagram of an OCT-based in-situ real-time biopsy system according to embodiment 3 of the present invention.
Wherein 1-a first optical fiber; 2-protecting sleeve; 3-a torque coil; 4-a collimating lens; a 5-focus lens; a 6-mirror; 7-fixing pieces; 8-fixing the sleeve; 9-magnet ring; 10-a metal housing; 11-perspective window; 12-magnet; 13-an electric motor; 14-pulleys; 15-a belt; 16-a second optical fiber; 17-biopsy needle; an 18-optocoupler; a 19-collimator; a 20-dispersion module; a 21-decay module; 22-plane mirrors; 23-spectrometer; a 24-image processing system; 25-a control terminal; 26-a light source; 27-a microcontroller.
Detailed Description
The invention will be further described with reference to the drawings and examples.
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the present invention. As used herein, the singular is also intended to include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that the terms "comprises" and/or "comprising" when used in this specification are taken to specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.
In the present invention, terms such as "upper", "lower", "left", "right", "front", "rear", "vertical", "horizontal", "side", "bottom", etc. refer to an orientation or a positional relationship based on that shown in the drawings, and are merely relational terms, which are used for convenience in describing structural relationships of various components or elements of the present invention, and do not denote any one of the components or elements of the present invention, and are not to be construed as limiting the present invention.
In the present invention, terms such as "fixedly attached," "connected," "coupled," and the like are to be construed broadly and refer to either a fixed connection or an integral or removable connection; can be directly connected or indirectly connected through an intermediate medium. The specific meaning of the terms in the present invention can be determined according to circumstances by a person skilled in the relevant art or the art, and is not to be construed as limiting the present invention.
Embodiments of the invention and features of the embodiments may be combined with each other without conflict.
Example 1:
as shown in fig. 1, embodiment 1 of the present invention provides an OCT-based in-situ real-time biopsy needle, comprising:
the optical fiber optical device comprises a first optical fiber 1, a protective sleeve 2, a moment coil 3, a collimating lens 4, a focusing lens 5, a reflecting mirror 6, a fixing piece 7 and a metal shell 10, wherein the first optical fiber 1 is embedded in the protective sleeve 2, and the moment coil 3 is fixed on the inner side wall of the protective sleeve 2 or embedded in the wall of the protective sleeve 2;
the first end of the first optical fiber 1 is used for receiving detection light or sending scattered light, the collimating lens 4, the focusing lens 5 and the reflecting mirror 6 are sequentially arranged in a hollow structure of the fixing piece 7 along a light path, the first opening end of the fixing piece 7 stretches into the protective sleeve 2 to be fixedly connected with the inner wall of the protective sleeve 2, and the second end of the first optical fiber 1 is opposite to the collimating lens 4 along the light path;
the position cover that is close to first optic fibre 1 first end in the protective sheath 2 outside is equipped with fixed cover 8, and fixed cover 8 outside cover is equipped with magnetic ring 9, and magnetic ring 9 is connected with the inside wall of metal casing 10 first end, and the lateral part of mounting 7 is opened to have the second opening relative with speculum 6 along the light path position, and metal casing 10 is equipped with perspective window 11 with the position relative of speculum 6, and metal casing 10 second end inboard is fixed with magnet 12 (i.e. magnetic element).
In this embodiment, the transparent window 11 is a continuous annular window to realize 360 ° detection, and it can be appreciated that in other embodiments, the transparent window is an intermittent annular window, and those skilled in the art may select the transparent window according to specific working conditions, which will not be described herein.
In this embodiment, the magnet 12 (i.e. the magnetic element) is disposed at the bottom of the second end of the metal casing 10, and it can be appreciated that in other embodiments, the magnet may be disposed on a side wall of the second end of the metal casing 10 near the bottom, or disposed on the side wall and the bottom, which may be selected by those skilled in the art according to specific working conditions, and will not be described herein again.
In this embodiment, the outgoing direction of the detection light of the reflection border 6 is perpendicular to the central axis of the metal housing 10, and it can be understood that in other embodiments, the outgoing direction of the detection light of the reflection border 6 is perpendicular to the central axis of the protective sleeve.
In this embodiment, in order to limit the axial and radial freedom of the free end of the first optical fiber 1 and the biopsy needle, but not limit the rotational freedom of the first optical fiber 1, the fixing member 7 and the fixing sleeve 8 are made of metal materials, and the positions of the needle tip and the needle tail of the biopsy needle are respectively provided with a magnet block and a magnet ring, so that the axial and radial freedom of the free end of the first optical fiber 1 are limited by magnetism, and the rotational freedom of the first optical fiber 1 is not affected.
In this embodiment, the protective sleeve 2, the torque coil 3, the collimating lens 4, the focusing lens 5, the reflecting mirror 6 and the fixing member 7 are integrated, and the pulley 14 drives the whole to rotate, so that the torque coil 3 bears the torque transmitted by the pulley 14, and the first optical fiber 1 is prevented from being damaged due to the torque.
Example 2:
as shown in fig. 2, embodiment 2 of the present invention provides an OCT-based in-situ real-time biopsy device, comprising: the motor, the belt pulley, the second optical fiber and the in-situ real-time biopsy needle based on OCT of the embodiment 1 of the invention;
the motor 13 is connected with the belt wheel 14 through a belt 15, a hollow shaft of the belt wheel 14 is connected with the protective sleeve 2 at the first end position of the first optical fiber 1, the second end of the second optical fiber 16 is opposite to one side of the collimating component along the optical path, and the other side of the collimating component is opposite to the first end of the first optical fiber 1 along the optical path.
In this embodiment, the second end of the second optical fiber 16 is fixedly connected to a supporting member, and the supporting member, the motor 13, and the pulley 14 are all fixed to a supporting base.
In this embodiment, the in-situ real-time biopsy of the living body adopts the OCT principle, where the optical fiber of the sample arm is divided into two parts, namely, a first optical fiber 1 and a second optical fiber 16, where the second end of the first optical fiber 1 is connected with the hollow shaft of the pulley 14, a small gap is left between the first optical fiber 1 and the second optical fiber 16, after being corrected by the collimating component, the laser emitted by the light source can be incident into the first optical fiber 1 through the second optical fiber 16, the second end of the second optical fiber 16 is fixed on the supporting component and is relatively stationary with the motor, the first optical fiber 1 is fixed on the hollow shaft and is a fixed end, and is relatively stationary with the pulley, and in the motion state, the second optical fiber 16 is stationary and the first optical fiber 1 is driven by the pulley to rotate relative to the first optical fiber 1.
Example 3:
the embodiment 3 of the invention provides an in-situ real-time biopsy system of a living body based on OCT, which comprises: a light source 26, an optical coupler 18, a spectrometer 23, a collimator 19, a dispersion module 20, an attenuation module 21, a plane mirror 22 and the in-situ real-time biopsy device based on OCT according to the embodiment 2 of the present invention;
the light source 26 and the spectrometer 23 are connected to a first end (i.e. a left end) of the optical coupler 18 by optical fibers, respectively, and a second end (i.e. a right end) of the optical coupler 18 is connected to a first end of the second optical fiber 16, and the second end of the optical coupler 18 is connected to one side of the collimator 19 by optical fibers, and the other side of the collimator 19 is provided with a dispersion module 20, an attenuation module 21 and a plane mirror 22 in this order along the optical path.
In this embodiment, the motor 13 is connected to a microcontroller 27, and the microcontroller 27 is connected to a control terminal 25; it may be appreciated that in other embodiments, the motor is in communication connection with the control terminal, and the control terminal directly performs motor control, so that a person skilled in the art may select according to a specific working condition, which is not described herein again, and the motor in this embodiment is a servo motor.
In this embodiment, the spectrometer 23 is communicatively connected to the image processing terminal 24, and the image processing terminal 24 is communicatively connected to the control terminal 25; it will be appreciated that in other embodiments, the spectrometer is communicatively connected to a control terminal, which has both control and image processing functions, and may be selected by those skilled in the art according to specific operating conditions, which will not be described herein.
In this embodiment, after the biopsy needle 17 is inserted into the lesion tissue, the motor transmits torque through the torque coil to drive the first optical fiber 1, the collimating lens 4, the focusing lens 5, the reflecting mirror 6 and the fixing piece 7 to rotate simultaneously, and the first optical fiber 1 emits laser to exit to the lesion tissue after passing through the collimating lens 4, the focusing lens 5 and the reflecting mirror 6, and scans the lesion tissue for 360 degrees through the perspective window 11 to obtain the pathological information of the lesion tissue;
the reference light reflected by the plane reflector 22 and the back scattered light of the measured sample are converged on the spectrometer 23, and interference occurs when the optical path difference between the two is within the coherence length of the light source;
the plane reflector 22 is scanned and the space position is recorded, so that the reference light interferes with the backward scattered light from different depths in the Z direction, the measurement data of different depths of the sample are obtained according to the position of the plane reflector 22 and the corresponding interference signal intensity, and the three-dimensional structure information of the sample is obtained by combining the scanning result of the sampling light beam in the XY plane.
The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. An OCT-based in-situ real-time biopsy needle, characterized in that:
comprising the following steps:
a first optical fiber, a protective sleeve, a moment coil, a collimating lens, a focusing lens, a reflecting mirror, a fixing piece and a metal shell, the first optical fiber is nested in the protective sleeve, and the moment coil is fixed on the inner side wall of the protective sleeve or embedded in the wall of the protective sleeve;
the first end of the first optical fiber is used for receiving detection light or sending scattered light, the collimating lens, the focusing lens and the reflecting mirror are sequentially arranged in the hollow structure of the fixing piece along the light path, the first opening end of the fixing piece extends into the protective sleeve and is fixedly connected with the inner wall of the protective sleeve, and the second end of the first optical fiber is opposite to the collimating lens along the light path;
the position cover that is close to first optic fibre first end in the protective sheath outside is equipped with fixed cover, and fixed cover outside cover is equipped with the magnetism ring, and magnetism ring is connected with the inside wall of metal casing first end, and the lateral part of mounting is opened to have the second opening relative along the light path position with the speculum, and the metal casing is equipped with perspective window with the relative position of speculum, and metal casing second end inboard is fixed with magnetic element, and mounting and fixed cover are the metal material.
2. The OCT based in-situ real-time biopsy needle of claim 1, wherein:
the perspective window is a continuous annular window or an intermittent annular window.
3. The OCT based in-situ real-time biopsy needle of claim 1, wherein:
the magnetic element is arranged at the bottom of the inner side of the second end of the metal shell.
4. The OCT based in-situ real-time biopsy needle of claim 1, wherein:
the emergent direction of the detection light of the reflection environment is perpendicular to the central axis of the metal shell; or the emergent direction of the detection light of the reflection environment is perpendicular to the central axis of the protective sleeve.
5. An in-situ real-time biopsy device of living body based on OCT, characterized in that:
comprising the following steps: a motor, pulley, second optical fiber, OCT-based biopsy needle of any one of claims 1-4 in real time in situ;
the motor is connected with the belt pulley through a belt, a hollow shaft of the belt pulley is connected with a protective sleeve at the first end position of the first optical fiber, the second end of the second optical fiber is opposite to one side of the collimating component along the optical path, and the other side of the collimating component is opposite to the first end of the first optical fiber along the optical path.
6. The OCT based in-situ real-time biopsy device of claim 5, wherein:
the second end of the second optical fiber is fixedly connected with the supporting component, and the supporting component and the motor are both fixed on the supporting base.
7. An OCT-based in-situ real-time biopsy system, characterized by:
comprising the following steps: a light source, an optical coupler, a spectrometer, a collimator, a dispersion module, an attenuation module, a planar mirror, and the OCT-based in-situ real-time biopsy device of claim 5 or 6;
the light source and the spectrometer are respectively connected with the first end of the optical coupler through optical fibers, the second end of the optical coupler is connected with the first end of the second optical fiber, the second end of the optical coupler is connected with one side of the collimator through the optical fibers, and the other side of the collimator is sequentially provided with a dispersion module, an attenuation module and a plane reflector along an optical path.
8. The OCT based in-situ real-time biopsy system of claim 7, wherein:
the motor is in communication connection with the control terminal; or, the motor is connected with a microcontroller, and the microcontroller is connected with a control terminal.
9. The OCT based in-situ real-time biopsy system of claim 7, wherein:
the spectrometer is in communication connection with the control terminal; alternatively, the spectrometer is in communication connection with an image processing terminal, which is in communication connection with a control terminal.
10. The OCT based in-situ real-time biopsy system of claim 7, wherein:
after the biopsy needle is inserted into the pathological tissue, the motor transmits torque through the torque coil to drive the first optical fiber, the collimating lens, the focusing lens, the reflecting mirror and the fixing piece to rotate simultaneously, and the first optical fiber emits laser to emit laser to the pathological tissue after passing through the collimating lens, the focusing lens and the reflecting mirror, and the pathological information of the pathological tissue is obtained by scanning the pathological tissue through 360 degrees through the perspective window;
the reference light reflected by the plane reflector and the back scattered light of the measured sample are converged on the spectrometer, and interference occurs when the optical path difference between the reference light and the back scattered light is within the coherence length of the light source;
and scanning the plane reflector and recording the space position, so that the reference light interferes with the backward scattered light from different Z-direction depths, obtaining measurement data of different sample depths according to the position of the plane reflector and the corresponding interference signal intensity, and obtaining the three-dimensional structure information of the sample by combining the scanning result of the sampling light beam in the XY plane.
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| CN201019719Y (en) * | 2007-03-29 | 2008-02-13 | 浙江大学 | Spectrum region OCT endoscopic image pick-up device used for in situ optical biopsy |
| CN106175700A (en) * | 2016-09-27 | 2016-12-07 | 广东永士达医疗科技有限公司 | A kind of OCT probe being applied to human body open pipes tract |
| WO2019183838A1 (en) * | 2018-03-28 | 2019-10-03 | 深圳市太赫兹科技创新研究院 | Optical coherence tomography system |
| CN110881942A (en) * | 2019-12-11 | 2020-03-17 | 上海交通大学 | OCT-based bimodal optical fiber endoscope device |
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| CN201019719Y (en) * | 2007-03-29 | 2008-02-13 | 浙江大学 | Spectrum region OCT endoscopic image pick-up device used for in situ optical biopsy |
| CN106175700A (en) * | 2016-09-27 | 2016-12-07 | 广东永士达医疗科技有限公司 | A kind of OCT probe being applied to human body open pipes tract |
| WO2019183838A1 (en) * | 2018-03-28 | 2019-10-03 | 深圳市太赫兹科技创新研究院 | Optical coherence tomography system |
| CN110881942A (en) * | 2019-12-11 | 2020-03-17 | 上海交通大学 | OCT-based bimodal optical fiber endoscope device |
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