CN115429280A

CN115429280A - Electrode assembly

Info

Publication number: CN115429280A
Application number: CN202211147393.XA
Authority: CN
Inventors: 王旭芳; 王璐璐; 鲁艺
Original assignee: Shenzhen Institute of Advanced Technology of CAS
Current assignee: Shenzhen Institute of Advanced Technology of CAS
Priority date: 2022-07-20
Filing date: 2022-09-20
Publication date: 2022-12-06

Abstract

The present application provides an electrode device. The electrode device comprises an electrode connector, at least one electrode and an electrode sleeve. Each electrode is secured to an electrode connector. At least one electrode is located to the electrode sleeve pipe cover and is fixed on the electrode connector, and the electrode sleeve pipe includes sleeve pipe main part and sleeve pipe anterior segment, and the sleeve pipe anterior segment is compared and is kept away from the electrode connector setting in sleeve pipe main part, and wherein, the pipe diameter of sleeve pipe anterior segment reduces along the direction of keeping away from sleeve pipe main part gradually. The application provides an electrode device, pipe diameter through setting up the sleeve pipe anterior segment reduces gradually, make the sleeve pipe anterior segment implant can reduce the damage that causes the tissue after the tissue, and can strengthen the toughness of sleeve pipe anterior segment, make the sleeve pipe anterior segment can be along with tissue deformation, thereby can further reduce the damage that causes the tissue, in addition, can adjust the size of sleeve pipe anterior segment according to the tissue that awaits measuring, in order to reduce the damage to the tissue that awaits measuring and do benefit to electrode and the tissue contact that awaits measuring.

Description

Electrode assembly

Technical Field

The application relates to the technical field of medical equipment, in particular to an electrode device.

Background

In the field of neuroscience, particularly behavioral research, simultaneous recording and regulation of neuronal activity is of great significance for functional analysis and pathological intervention of the nervous system. Thanks to the development of the electronic manufacturing industry, the computer industry and the like, tungsten wire electrodes are developed in 1957, traditional electrodes represented by four electrodes, michigan electrodes and Utah micro-arrays are developed, and then the electrodes are upgraded into novel electrode arrays with the characteristics of high density, long-term stable implantation, multifunctional integration and the like, and the development of the electrode arrays in the past sixty years can be a rapid progress, so that the research on neuroscience is promoted.

At present, a silicon tube electrode is generally used for cell specificity regulation and electrophysiological recording, and the front end of the silicon tube is in a straight tube shape, and the silicon tube in industrial production has larger and uniform size, so that the electrode has larger damage to tissue after being implanted into animal tissue, and the silicon tube size cannot be adaptively adjusted aiming at specific action tissue in practical application.

Disclosure of Invention

In order to solve the technical problem, the application provides an electrode device, can reduce the damage that causes to the tissue that awaits measuring, and can make adaptability adjustment to the tissue that awaits measuring.

An electrode assembly includes an electrode connector, at least one electrode, and an electrode sleeve. Each electrode is secured to the electrode connector. The electrode sleeve is sleeved on the at least one electrode and fixed on the electrode connector, the electrode sleeve comprises a sleeve main body and a sleeve front section, the sleeve front section is far away from the electrode connector compared with the sleeve main body, and the pipe diameter of the sleeve front section is gradually reduced along the direction far away from the sleeve main body.

The application provides an electrode device, through setting up the pipe diameter of electrode sleeve's sleeve pipe anterior segment reduces along the direction of keeping away from the sleeve pipe main part gradually for can reduce the damage that causes the tissue after the sleeve pipe anterior segment is implanted the tissue, and can strengthen through setting up the pipe diameter reduces gradually the toughness of sleeve pipe anterior segment makes can follow tissue deformation in certain extent after the sleeve pipe anterior segment is implanted the tissue, thereby can further reduce the damage that causes the tissue, and can protect the electrode to make its top be difficult by the rupture. In addition, the size of the sleeve front section of the electrode sleeve can be adjusted according to specific tissues to be detected, so that the damage to the tissues to be detected is reduced, and the contact between the electrode and the tissues to be detected is facilitated.

Drawings

In order to more clearly illustrate the technical solution of the present application, the drawings needed to be used in the embodiments will be briefly described below, and obviously, the drawings in the following description are some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.

Fig. 1 is a schematic structural diagram of an electrode device provided in an embodiment of the present application.

Fig. 2 is an enlarged view of a in fig. 1.

Fig. 3 is a schematic structural diagram of an electrode according to an embodiment of the present application.

Fig. 4 is a schematic structural diagram of an electrode according to another embodiment of the present application.

Description of the main element symbols:

electrode assembly 100

Electrode connector 10

Electrode 20

Electrode sleeve 30

Sleeve body 31

Sleeve front section 32

First end 21

Second end 22

Sub-electrode 23

Insulating layer 40

Optical fiber 50

Administration tube 60

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without inventive step, are within the scope of the present disclosure.

In the description of the present application, the terms "first", "second", etc. are used for distinguishing different objects and not for describing a particular order, and in addition, the terms "upper", "inner", "outer", etc. indicate orientations or positional relationships based on those shown in the drawings only for convenience of description and simplification of description, but do not indicate or imply that the referred device or element must have a particular orientation, be constructed in a particular orientation, and operate, and thus, should not be construed as limiting the present application.

Throughout the description of the present application, unless expressly stated or limited otherwise, the term "coupled" is to be construed broadly, e.g., as meaning fixedly attached, detachably attached, or integrally attached; the two elements can be directly connected, indirectly connected through an intermediate medium, or communicated with each other inside; may be a communication connection; may be an electrical connection. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.

Referring to fig. 1 and fig. 2 together, fig. 1 is a schematic structural diagram of an electrode device 100 according to an embodiment of the present disclosure, and fig. 2 is an enlarged view of a in fig. 1. As shown in fig. 1 and 2, the electrode device 100 includes an electrode connector 10, at least one electrode 20, and an electrode bushing 30. Each electrode 20 is fixed to the electrode connector 10. The electrode sleeve 30 is sleeved on the at least one electrode 20 and fixed on the electrode connector 10, the electrode sleeve 30 includes a sleeve main body 31 and a sleeve front section 32, the sleeve front section 32 is disposed far away from the electrode connector 10 than the sleeve main body 31, and a tube diameter of the sleeve front section 32 is gradually reduced along a direction far away from the sleeve main body 31. In some embodiments, as shown in FIG. 2, the forward section 32 of the sleeve may be conical.

The embodiment of the present application provides the electrode device 100, through setting up the pipe diameter of the sleeve pipe anterior segment 32 of the electrode sleeve 30 gradually reduces along the direction of keeping away from the sleeve main body 31, make the damage that can reduce to the tissue and cause after the sleeve pipe anterior segment 32 implants the tissue, and can strengthen through setting up the toughness of sleeve pipe anterior segment 32 that reduces gradually, make can follow tissue deformation in certain extent after the sleeve pipe anterior segment 32 implants the tissue, thereby can further reduce the damage that causes the tissue, and can protect electrode 20 to make its top difficult for breaking. In addition, the size of the front sleeve section 32 of the electrode sleeve 30 can be adjusted according to the specific tissue to be measured, so as to reduce the damage to the tissue to be measured and facilitate the contact between the electrode 20 and the tissue to be measured.

The electrode sleeve 30 is fixed to the electrode connector 10 through the sleeve main body 31, and specifically, one end of the sleeve main body 31, which is far away from the sleeve front section 32, is fixed to the electrode connector 10.

As shown in fig. 1 and 2, each electrode 20 includes a first end 21 and a second end 22 opposite to each other, the first end 21 of each electrode 20 is fixed to the electrode connector 10, and the second end 22 of each electrode 20, which is far away from the electrode connector 10, extends from the casing front section 32 of the electrode casing 30. The second end 22 is used to contact a target area of a tissue to be tested to collect electrical signals generated by the tissue to be tested or to stimulate the tissue to be tested for cellular regulation and repair, for example, to collect electrical signals generated by peripheral nerves or to stimulate motor fibers of muscles.

Wherein, the electrode sleeve 30 comprises a first port and a second port, the first port is the end of the sleeve main body 31 far away from the sleeve front section 32, the second port is the end of the sleeve front section 32 far away from the sleeve main body 31, the electrode sleeve 30 is fixedly connected with the electrode connector 10 through the end edge of the first port, for example, the end edge of the first port can be adhered to the electrode connector 10 by using glue to fix the electrode sleeve 30 on the electrode connector 10, or the electrode connector 10 is provided with a groove matched with the end edge of the first port, and the electrode sleeve 30 is fixed on the electrode connector 10 by embedding the first port in the groove. Wherein the second port is used for the first end 21 of each electrode 20 to pass through and be fixed on the electrode connector 10, and the second port is used for the second end 22 of at least one electrode 20 to extend out.

One side of the electrode connector 10 close to the electrode sleeve 30 is provided with at least one electrode interface, each electrode interface is used for being electrically connected with the first end 21 of one electrode 20, a circuit is arranged in the electrode connector 10, and the at least one electrode interface is connected with a signal processing assembly or an electrical stimulator through the circuit. The second end 22 of each electrode 20, which is far away from the electrode connector 10, extends out of the casing front section 32 of the electrode casing 30, and then can contact with the tissue to be tested to collect a corresponding electrical signal, and the electrode 20 can transmit the collected electrical signal to the signal processing assembly through the electrode interface connected with the electrode 20, so that the signal processing assembly processes the electrical signal generated by the tissue to be tested. Alternatively, the electrical stimulator may apply electrical stimulation to the at least one electrode 20 through the at least one electrode interface to electrically stimulate the tissue under test in contact with the second end 22 of the at least one electrode 20 for cellular regulation and repair. Wherein the electrode interface may be a pin, and the electrode 20 may be fixed to the electrode connector 10 by welding the first end 21 and the pin together.

The electrode sleeve 30 may be an integrally formed structure.

The arrangement of the at least one electrode 20 may vary according to different requirements, and for example, the at least one electrode may be arranged in a matrix, a circle, or any other arrangement.

The length of the at least one electrode 20 may be the same or different, and is specifically set according to the actual test requirement.

The electrode 20 may be made of a metal material, such as nickel-cadmium alloy, platinum-iridium alloy, etc., which has good electrical conductivity, stable chemical properties, and corrosion resistance, and does not react with the electrolyte of the tissue to be measured. In other embodiments, the material of the electrode 20 may also be carbon nanotubes, graphene, conductive polymers, and the like.

The electrode device 100 is used for implanting into tissue structures such as nervous system tissues of human body, animals and the like, and detecting and/or repairing the tissue structures. The electrode device 100 may be configured to collect an electrical signal of a tissue to be measured, specifically, the electrode device 100 may be implanted into the tissue to be measured, the at least one electrode 20 contacts with a target region of the tissue to be measured, and collects an electrical signal generated in the target region, and more specifically, the second end 22 of the at least one electrode 20 extending from the casing front section 32 of the electrode casing 30 contacts with the target region of the tissue to be measured, so as to collect the electrical signal generated in the target region. For example, the mouse may be opened at the neck, the submandibular gland and other tissues are blunt-separated, the vagus nerve node located beside the carotid artery is exposed, the electrode connector 10 is left outside the body, the electrode sleeve 30 is extended to the vagus nerve node, the electrode sleeve 30 is fixed by means of a clamp, the second end 22 of the at least one electrode 20 is adjusted to the target region of the vagus nerve, the second end 22 of the at least one electrode 20 is fixed to the target region by using tissue glue, and finally the wound is sutured. Wherein, because the pipe diameter of sleeve pipe anterior segment 32 is along keeping away from the direction of electrode connector 10 reduces gradually, promptly the pipe diameter of sleeve pipe anterior segment 32 is along being close to the direction of the tissue that awaits measuring reduces gradually, thereby can reduce the damage that sleeve pipe anterior segment 32 caused to the tissue that awaits measuring, and can strengthen through setting up the pipe diameter reduces gradually the toughness of sleeve pipe anterior segment 32 makes sleeve pipe anterior segment 32 can produce the deformation along with the vagus nerve, thereby further reduces the damage of vagus nerve.

In some embodiments, the tube diameter of the front sleeve section 32 decreases linearly in a direction away from the main sleeve body 31, i.e. the tube diameter of a position of the front sleeve section 32 is smaller than that of a position closer to the main sleeve body 31 than the position, as shown in fig. 2.

Through setting up the pipe diameter of sleeve pipe anterior segment 32 is linear and reduces, can make the surface of sleeve pipe anterior segment 32 is comparatively level and smooth, and can not unevenness, thereby can further reduce the damage that electrode sleeve pipe 30 caused to the tissue that awaits measuring. Furthermore, the linear reduction of the pipe diameter of the front sleeve section 32 makes the front sleeve section 32 easier to manufacture.

In some embodiments, the tube diameters of the sleeve body 31 are equal along the extension direction of the sleeve body 31. The pipe diameters of the sleeve main bodies 31 may be substantially equal along the extending direction of the sleeve main bodies 31, that is, equal within a certain error range. Due to the limitation of the manufacturing process, there may be a certain difference in pipe diameters at different positions of the sleeve main body 31, and therefore the pipe diameters of the sleeve main body 31 may be substantially equal.

The tube diameters of the different positions of the sleeve main body 31 are set to be approximately equal, the manufacturing process of the electrode sleeve 30 can be simplified, the manufacturing cost is reduced, and the damage to the tissue to be measured can be reduced due to the sleeve main body 31 with uniform tube diameters.

In some embodiments, the electrode sleeve 30 is a glass tube.

The electrode sleeve 30 may be formed by drawing a glass tube, so that the manufactured electrode sleeve 30 is an integrally formed structure, the glass tube may be a capillary glass tube, specifically, the capillary glass tube is drawn by using a drawing instrument, first, drawing parameters of the drawing instrument may be set according to a specific position of a tissue to be measured, for example, a length and a tube diameter of the sleeve front section 32 and a length of the sleeve main body 31 may be determined according to a depth of the tissue to be measured from a body surface, and then drawing parameters of the drawing instrument may be set according to the determined length and tube diameter of the sleeve front section 32 and the length of the sleeve main body 31; then, the capillary glass tube is mounted on a drawing machine, and the drawing machine is started up, and the drawing machine draws the capillary glass tube according to the set drawing parameters to obtain the electrode sleeve 30. The length of the sleeve front section 32 is the dimension of the sleeve front section 32 in the extending direction of the sleeve front section 32, and the length of the sleeve main body 31 is the dimension of the sleeve main body 31 in the extending direction of the sleeve main body 31.

Wherein, the glass tube has a low cost and is very common, and the electrode sleeve 30 is formed by drawing the glass tube, so that the manufacturing cost of the electrode sleeve 30 can be greatly reduced and the manufacturing efficiency can be improved, thereby being beneficial to the reduction of the production cost and the improvement of the production efficiency of the electrode device 100.

Wherein, when the tissue that awaits measuring is darker apart from the body surface, can set up sleeve pipe anterior segment 32 is longer just sleeve pipe anterior segment 32's tapering is less, promptly sleeve pipe anterior segment 32 is longer and more sharp, thereby does benefit to sleeve pipe anterior segment 32 stretches into to the tissue department that awaits measuring, and the length of sleeve pipe anterior segment 32 is longer, and the tapering is less, can make sleeve pipe anterior segment 32's toughness is better, thereby is favorable to more sleeve pipe anterior segment 32 produces deformation along with the motion of the tissue that awaits measuring, and then reduces the destruction to the tissue that awaits measuring, and reduces sleeve pipe anterior segment 32 with at least one electrode 20 is by the risk of rupture. In addition, the main body 31 of the cannula can be longer, and the length of the main body 31 of the cannula is long enough to enable the electrode connector 10 to be located outside the living body when the front section 32 of the cannula is in contact with the tissue to be measured. When the target area of the tissue to be measured is less, the distance of the front sleeve segment 32 from the pipe diameter of one end of the main sleeve body 31 is less, so that the front sleeve segment 32 is kept away from the one end of the main sleeve body 31 and the target area of the tissue to be measured are accurately contacted, and the electric signal generated by the target area is collected by the at least one electrode 20.

Therefore, the length, the taper and the pipe diameter of the front section 32 of the sleeve pipe and the length and the pipe diameter of the main body 31 of the sleeve pipe are set according to the depth and/or the size of a target area of the tissue to be detected, so that the damage to the tissue to be detected can be reduced as much as possible, and the contact between the at least one electrode 20 and the tissue to be detected is facilitated, and the electric signal is acquired. The length, taper and pipe diameter of the front casing section 32 and the pipe diameter of the main casing body 31 can be adjusted according to the number of the at least one set electrode 20, for example, when the number of the at least one set electrode 20 is small, the pipe diameter of the front casing section 32 and the pipe diameter of the main casing body 31 can be adjusted to be small, so as to reduce the damage in the living body.

In other embodiments, the pipe diameters of the sleeve body 31 may not be equal along the extending direction of the sleeve body 31.

Referring to fig. 3, fig. 3 is a schematic structural diagram of an electrode 20 according to an embodiment of the present disclosure. In some embodiments, as shown in fig. 3, the outer surface of the portion of each electrode 20 other than the first and second ends 21 and 22 is provided with an insulating layer 40.

Wherein, the insulating layer 40 covers at least part of the side wall of the electrode 20, and at least the end face of the electrode 20 close to the electrode connector 10 and the end face far away from the electrode connector 10 are exposed.

The insulating layer 40 may be made of a high molecular material, such as polyacrylic polymer, polyacrylate polymer, epoxy polymer, polyimide, parylene, and the like. The polyacrylate polymer may include polymethyl acrylate polymer, polyethyl acrylate polymer, polypropyl acrylate polymer, polybutyl acrylate polymer, polypentyl acrylate polymer, and the like. The epoxy resin-based polymer may include bisphenol a type epoxy resin, modified epoxy resin, and the like. The insulating layer 40 made of the above polymer has little biotoxicity and has little influence on the tissue to be measured.

The insulating layer 40 is disposed on the outer surface of the electrode 20, so that short circuit between the electrode 20 and other electrodes 20 can be prevented, and the hardness of the electrode 20 can be improved, so that the electrode 20 can better enter into a tissue to be detected and be positioned to a target area, thereby facilitating the electrode 20 to acquire an electric signal of the target area. In addition, when the collection is finished, the electrode 20 can still keep a good shape after being taken out of the tissue to be detected, and the reuse of the electrode 20 is facilitated.

In some embodiments, as shown in fig. 3, each electrode 20 includes two sub-electrodes 23, the two sub-electrodes 23 are disposed in parallel, one end of each electrode 20, close to the electrode connector 10, of each sub-electrode 23 is connected to the electrode connector 10, and one end of each electrode 20, far from the electrode connector 10, of each sub-electrode 23 is spaced apart from the electrode connector 10, so that each sub-electrode 23 independently collects electrical signals of the tissue to be measured in contact therewith, that is, each sub-electrode 23 forms a separate collection channel. Thus, each electrode 20 has two separate acquisition channels. Wherein, the ends of the two sub-electrodes 23 far away from the electrode connector 10 constitute the second ends 22 of the corresponding electrodes 20, and the ends of the two sub-electrodes 23 close to the electrode connector 10 of each electrode 20 constitute the first ends 21 of the corresponding electrodes 20.

Wherein the outer surface of the portion other than both ends of each sub-electrode 23 is provided with an insulating layer 40. Wherein, the insulating layer 40 wraps at least part of the side wall of the sub-electrode 23, and at least the end surface of the sub-electrode 23 far away from the electrode connector 10 and the end surface of the sub-electrode 23 close to the electrode connector 10 are exposed.

In some embodiments, as shown in fig. 3, the two sub-electrodes 23 of each electrode 20 are helically wound together.

The two sub-electrodes 23 are wound together, so that the strength of the electrode 20 can be enhanced, the electrode 20 is not easy to bend and deform when contacting with a tissue to be detected, implantation is facilitated, the size of the electrode 20 can be reduced, the space occupied by the electrode 20 during implantation can be reduced, and damage to the tissue to be detected can be further reduced.

Referring to fig. 4, fig. 4 is a schematic structural diagram of an electrode 20 according to another embodiment of the present disclosure. In some embodiments, as shown in fig. 4, the two sub-electrodes 23 may be disposed substantially in parallel. The two sub-electrodes 23 are arranged to be approximately parallel, so that the difficulty of the manufacturing process can be reduced, and the process flow is simplified.

In some embodiments, the electrode 20 may be formed by bending a wire electrode, specifically, the side wall of the wire electrode is provided with an insulating layer 40, the two sub-electrodes 23 may be formed by bending the wire electrode and then cutting the wire electrode at the bent portion, further, the two sub-electrodes 23 may be spirally wound together, and then the portion of the insulating layer 40 at the cut portion is removed, so that the portion of the cut portion of the two sub-electrodes 23 is completely exposed, that is, the electrode 20 is formed. The fixation of the electrode 20 to the electrode connector 10 can then be achieved by welding the portions of the two sub-electrodes 23 at the cut-off to the pins of the electrode connector 10.

Wherein, an appropriate length of the wire electrode can be selected according to the depth of the tissue to be measured, so that the electrode 20 formed by the wire electrode is sufficiently implanted into the target region of the tissue to be measured.

The diameter of the electrode wire can be set according to actual requirements, and in some embodiments, the diameter of the electrode wire can be 12 μm.

In some embodiments, the two sub-electrodes 23 of each electrode 20 may be two independent structures, one end of the two sub-electrodes 23 close to the electrode connector 10 constitutes the first end 21 of the corresponding electrode 20, and one end of the two sub-electrodes 23 far from the electrode connector 10 constitutes the second end 22 of the corresponding electrode 20. The ends of the two sub-electrodes 23 close to the electrode connector 10 may be connected to the same electrode interface. The two sub-electrodes 23 may form two separate acquisition channels.

Wherein, the two sub-electrodes 23 may be spirally wound together. In other embodiments, the two sub-electrodes 23 may be disposed substantially in parallel.

In some embodiments, as shown in fig. 1 and 2, the electrode device 100 further includes an optical fiber 50 and/or a drug delivery tube 60, the optical fiber 50 is disposed on the side of the electrode connector 10 where the electrode sleeve 30 is disposed and is spaced apart from the electrode sleeve 30, and at least a portion of the drug delivery tube 60 is inserted into the electrode sleeve 30.

Wherein the administration tube 60 is for topical administration. The electrode connector 10 may be provided with a through hole penetrating the electrode connector 10 along an extending direction of the electrode sleeve 30, and the drug administration tube 60 includes a drug inlet end and a drug outlet end opposite to each other, the drug outlet end passes through the through hole and is inserted into the electrode sleeve 30, and the drug inlet end is located on one side of the electrode connector 10 away from the electrode sleeve 30. Wherein the administration tube 60 may be fixed to the electrode connector 10 at the through hole using an insulating paste. A syringe may be used to inject the medical fluid from the drug delivery end to effect delivery to the target tissue.

The tube diameter of the drug delivery tube 60 can be set according to the tube diameter of the electrode sleeve 30, so that the drug delivery tube 60 can be smoothly inserted into the electrode sleeve 30 and spaced from the at least one electrode 20 as far as possible.

The administration tube 60 may be made of a polymer material, for example, polyethylene, polyvinyl chloride, or the like.

By using the electrode cannula 30 instead of a conventional metal administration cannula to cover the administration tube 60, damage to the tissue to be administered can be greatly reduced.

The optical fiber 50 and the electrode sleeve 30 may be disposed adjacent to each other, the optical fiber 50 is used for transmitting light to the tissue to be measured to perform optical stimulation on the tissue to be measured, and the at least one electrode 20 may collect an electrical signal generated by the tissue to be measured that is subjected to optical stimulation.

The optical fiber 50 may be a flexible optical fiber, and the flexible optical fiber can deform along with the movement of the tissue to be detected when being implanted into the tissue to be detected, so as to reduce the damage to the tissue to be detected.

The electrode device 100 may further include other functional components, and a user may set different functional components on the electrode connector 10 according to actual needs to implement corresponding functions.

In the foregoing embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments.

The foregoing is an implementation of the embodiments of the present application, and it should be noted that, for those skilled in the art, several modifications and decorations can be made without departing from the principle of the embodiments of the present application, and these modifications and decorations are also regarded as the protection scope of the present application.

Claims

1. An electrode device, characterized in that it comprises:

an electrode connector;

at least one electrode, each electrode being secured to the electrode connector; and

the electrode sleeve is sleeved on the at least one electrode and fixed on the electrode connector, the electrode sleeve comprises a sleeve main body and a sleeve front section, the sleeve front section is far away from the electrode connector compared with the sleeve main body, and the pipe diameter of the sleeve front section is gradually reduced along the direction far away from the sleeve main body.

2. The electrode assembly of claim 1 wherein each electrode includes opposite first and second ends, the first end of each electrode being secured to the electrode connector, the second end of each electrode distal from the electrode connector extending from the forward sleeve section of the electrode sleeve.

3. The electrode device of claim 1, wherein the diameter of the front section of the sleeve decreases linearly in a direction away from the sleeve body.

4. The electrode device of claim 1, wherein the tube diameters of the sleeve bodies are equal along the extension direction of the sleeve bodies.

5. The electrode device of claim 1, wherein the electrode sleeve is a glass tube.

6. An electrode arrangement according to claim 2, wherein the outer surface of the portion of each electrode other than the first and second ends is provided with an insulating layer.

7. The electrode device according to claim 2, wherein each electrode comprises two sub-electrodes, the two sub-electrodes are arranged in parallel, one ends of the two sub-electrodes of each electrode, which are close to the electrode connector, are fixedly connected with the electrode connector respectively, one ends of the two sub-electrodes of each electrode, which are far from the electrode connector, are arranged at intervals, and the outer surface of the part of each sub-electrode, which is outside the two ends, is provided with an insulating layer.

8. The electrode device of claim 7, wherein the two sub-electrodes of each electrode are spirally wound together or arranged in parallel.

9. The electrode device of claim 1, further comprising an optical fiber disposed on a side of the electrode connector where the electrode sleeve is disposed and spaced apart from the electrode sleeve.

10. The electrode device of claim 1, further comprising an administration tube, at least a portion of which is inserted within the electrode sheath.

11. The electrode assembly of claim 1 wherein said electrode sheath is of unitary construction.