CN115403678B - Moisturizing gel and preparation method thereof - Google Patents

Moisturizing gel and preparation method thereof Download PDF

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CN115403678B
CN115403678B CN202210910728.2A CN202210910728A CN115403678B CN 115403678 B CN115403678 B CN 115403678B CN 202210910728 A CN202210910728 A CN 202210910728A CN 115403678 B CN115403678 B CN 115403678B
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moisturizing gel
water
reaction
moisturizing
glycidyl methacrylate
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CN115403678A (en
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吕继祥
李玉博
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Jiahua Science and Technology Development Shanghai Ltd
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Jiahua Science and Technology Development Shanghai Ltd
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
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    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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Abstract

The invention relates to the technical field of biological cosmetics, and in particular provides a preparation method of moisturizing gel, which comprises the following steps: s1, step: guar gum reacts with glycidyl methacrylate under the action of a catalyst; s2, step: reacting the product of the step S1 with a sulfhydryl compound under ultraviolet light; s3, step: and (3) mixing the product of the step (S2) with a cross-linking agent, and heating to obtain the moisturizing gel. The invention adopts guar gum, glycidyl methacrylate and sulfhydryl compound to form a hydrophilic structure with flexible molecular chains, the structure contains a large number of hydrophilic groups, the flexible molecular chains obviously reduce the crosslinking density of the crosslinking reaction, and the moisturizing gel obtained after crosslinking has obviously improved water absorption performance and water retention performance.

Description

Moisturizing gel and preparation method thereof
Technical Field
The invention relates to the technical field of biological cosmetics, in particular to a moisturizing gel and a preparation method thereof.
Background
In the current society, various pollutions are serious, the damage of ecological environment has great influence on the skin of people, and the skin mainly comprises yellowing, aging, darkening of skin color, no luster and the like, and even part of people also have serious color spots. Healthy skin should be smooth, moist and elastic, and these appearance signs are related to the function of the skin's own moisturizing system. The moisturizing system has the functions of maintaining a certain moisture content of the skin, and the sufficient hydration is beneficial to enzymatic reaction and can promote the maturation of the stratum corneum and maintain the elasticity of the stratum corneum. Therefore, the moisturizing of the skin is also the basis of modern beauty and skin care.
Humectants are a class of compounds that absorb moisture in a humid environment and are low in volatility and retain the moisture. The external humectant in the moisturizing skin care product also has the effects of supplementing skin moisture, preventing excessive loss of moisture and keeping the healthy state of skin. If the water content of the horny layer is less than 10%, skin dryness occurs, hyaluronic acid in dermis is reduced, mucopolysaccharide is denatured, blood vessel constriction and blood vessel wall permeability of the upper layer of dermis are reduced, the water content of dermis is reduced, and skin aging phenomena such as dryness, mattness, elasticity reduction, wrinkle increase and the like are caused.
Conventional humectants can be divided into three categories: inorganic moisturizers, organic moisturizers, and metal-organic moisturizers. The inorganic humectant is calcium chloride; organic humectants include polyols, amino acids and polysaccharides; metal-organic humectants include lactate and gluconate.
The novel moisturizer mainly comprises a gel moisturizer and a foam moisturizer, and the function principle of the novel moisturizer is that the gel moisturizer or the foam moisturizer can keep certain wettability by blocking air. Although the use speed of the foam humectant is high, foam is pumped out by means of an efficient pressing foaming pump head, and the defoaming time is long.
The moisturizing gel used in cosmetics or skin care products at present mainly comprises carbomer resin gel, modified starch, modified cellulose gel and the like, wherein the carbomer resin has important applications such as thickening, suspending and the like, and has simple process, good stability and high transparency, but the moisturizing capability of the moisturizing gel for absorbing water has certain limitations, so that development of the moisturizing gel with high water absorption and moisturizing capability is needed.
Disclosure of Invention
Therefore, the technical problem to be solved by the invention is to overcome the defect of poor water absorption and moisture retention effects of the moisture retention gel in the prior art, thereby providing the moisture retention gel and the preparation method thereof.
The invention provides a preparation method of moisturizing gel, which comprises the following steps:
s1, step: guar gum reacts with glycidyl methacrylate under the action of a catalyst;
s2, step: reacting the product of the step S1 with a sulfhydryl compound under ultraviolet light;
s3, step: and (3) mixing the product of the step (S2) with a cross-linking agent, and heating to obtain the moisturizing gel.
Further, the catalyst is a basic catalyst, preferably, the catalyst is selected from at least one of potassium hydroxide, sodium hydroxide and sodium carbonate.
Further, in the step S1, the reaction is carried out under the atmosphere of nitrogen or inert gas, preferably, the reaction temperature is 50-60 ℃ and the time is 2-10h.
The inert gas in the invention can be helium, neon, argon and other common inert gases.
Further, the mass ratio of glycidyl methacrylate to guar gum is 1:10-10:1, preferably 1:3-3:1.
Further, the mass of the catalyst accounts for 0.5-5% of the mass of the glycidyl methacrylate; and/or, in the step S1, water is used as a solvent for reaction.
Further, in the step S1, the glycerol methacrylate and the aqueous solution containing 5-15 wt% of the catalyst are added into the aqueous solution containing 10-20wt% of guar gum for reaction.
Further, the structural formula of the sulfhydryl compound is HS-R 1 Wherein R is 1 Is a substituted or unsubstituted C2-C10 alkyl group, or a substituted or unsubstituted polyethylene glycol having an average molecular weight of 400 to 800, wherein the substitution means that 1 to 2 hydrogen atoms on the alkyl group or the polyethylene glycol are substituted with a member selected from the group consisting of amino, carboxyl, and hydroxyl; preferably, the sulfhydryl compound is selected from the group consisting of mercaptoethylamine, mercaptopropylamine, HS-PEG-NH 2 At least one of 3-mercapto-1-hexanol, 6-mercapto-1-hexanol, HS-PEG, 3-mercapto-1-propanol, and HS-PEG-OH.
Further, the mass of the sulfhydryl compound accounts for 3-10 percent of the mass of the glycidyl methacrylate; and/or, the method further comprises the steps of cooling, dialyzing and drying the reactant in the step S2.
Further, in the step S2, the reaction is performed under an atmosphere of nitrogen or inert gas, preferably, the reaction temperature is 50-60 ℃ for 1-5 hours.
Further, the ultraviolet light wavelength is 365nm.
Further, in the dialysis process, the dialysis medium is deionized water, and a dialysis bag with a molecular weight cut-off of 5000 is adopted.
Further, the cross-linking agent is at least one selected from ethylene glycol diglycidyl ether, 1, 4-butanediol diglycidyl ether, 1, 6-hexanediol diglycidyl ether, polypropylene glycol diglycidyl ether, polyethylene glycol diglycidyl ether and glycerol triglycidyl ether; and/or the cross-linking agent accounts for 0.1-5% of the glycidyl methacrylate by mass; and/or in step S3, the reaction temperature is 40-60 ℃ for at least 0.5 hours (e.g., 0.5-2 hours); and/or, in the step S3, water is used as a solvent for reaction.
The invention also provides the moisturizing gel prepared by the preparation method.
The technical scheme of the invention has the following advantages:
1. according to the preparation method of the moisturizing gel, guar gum reacts with glycidyl methacrylate under the action of a catalyst; reacting the product of the step S1 with a sulfhydryl compound under ultraviolet light; the product of the step S2 is mixed with a cross-linking agent and heated to prepare the moisturizing gel, and the guar gum, the glycidyl methacrylate and the sulfhydryl compound are reacted to form a hydrophilic structure with flexible molecular chains, the structure contains a large number of hydrophilic groups, the cross-linking density of the cross-linking reaction is obviously reduced by the flexible molecular chains, and the moisturizing gel obtained after the cross-linking has obviously improved water absorption performance and water retention performance.
Illustrating: in the step S1 and the step S2, potassium hydroxide or sodium hydroxide is used as a catalyst, mercaptoethylamine is used as a mercapto compound, and the reaction flow is as follows:
2. the structural formula of the sulfhydryl compound is HS-R 1 Wherein R is 1 Alkyl of C2-C10, optionally substitutedOr a substituted or unsubstituted polyethylene glycol having an average molecular weight of 400 to 800, wherein the substituted means that 1 to 2 hydrogen atoms of the alkyl group or the polyethylene glycol are replaced with a member selected from the group consisting of amino, carboxyl, and hydroxyl groups; in particular, the mercapto compound is selected from mercaptoethylamine, mercaptopropylamine, HS-PEG-NH 2 At least one of 3-mercapto-1-hexanol, 6-mercapto-1-hexanol, HS-PEG, 3-mercapto-1-propanol, and HS-PEG-OH. Functional groups (such as amino, hydroxyl, carboxyl and the like) are connected into the moisturizing gel through the sulfhydryl compound, so that the biocompatibility of the moisturizing gel is enlarged, and the moisturizing gel can be widely applied to the field of biological medicines or cosmetics. The moisturizing gel has good stability, can coexist with acid skin-active components and salt substances, and has wide application range.
Detailed Description
The following examples are provided for a better understanding of the present invention and are not limited to the preferred embodiments described herein, but are not intended to limit the scope of the invention, any product which is the same or similar to the present invention, whether in light of the present teachings or in combination with other prior art features, falls within the scope of the present invention.
The specific experimental procedures or conditions are not noted in the examples and may be followed by the operations or conditions of conventional experimental procedures described in the literature in this field. The reagents or apparatus used were conventional reagent products commercially available without the manufacturer's knowledge.
Example 1
The embodiment provides a preparation method of moisturizing gel, which comprises the following steps:
(1) Dissolving 10 g of guar gum into 80 g of water, adding the water into a three-neck flask, magnetically stirring the water by using a rotor, continuously introducing nitrogen into the three-neck flask after sealing the three-neck flask, keeping the water bath temperature at 50 ℃, adding 5 g of glycidyl methacrylate and 2 g of 10wt% sodium hydroxide aqueous solution, continuously introducing nitrogen to react for 2 hours, dropwise adding 0.5 g of mercaptoethylamine into the three-neck flask, continuously introducing nitrogen, continuously using 365nm ultraviolet light to irradiate, continuously stirring the water for 1 hour, stopping introducing nitrogen while stopping stirring, cooling the water to room temperature, filling the product in the three-neck flask into a dialysis bag with a molecular weight cut-off of 5000, cleaning the product in deionized water, taking out a sample in the dialysis bag for rotary steaming and freeze drying when the pH of the solution is about 7.
(2) 1 g of the reaction product obtained in the step (1) is added with water to prepare a 2wt% solution, then 0.2 g of 1, 4-butanediol diglycidyl ether is added, and after being stirred uniformly, the mixture is poured into a mold and put into a baking oven at 50 ℃ for 1 hour, and the moisturizing gel is prepared.
Example 2
The embodiment provides a preparation method of moisturizing gel, which comprises the following steps:
(1) Dissolving 10 g of guar gum into 80 g of water, adding the water into a three-necked flask, magnetically stirring the water by using a rotor, sealing the three-necked flask, continuously introducing nitrogen for 5 minutes, keeping the water bath temperature at 50 ℃, adding 5 g of glycidyl methacrylate and 2 g of 10wt% of potassium hydroxide aqueous solution, continuously introducing nitrogen for reacting for 2 hours, and then dropwise adding 0.5 g of HS-PEG-NH into the three-necked flask 2 And continuously introducing nitrogen, using 365nm ultraviolet light for irradiation, continuously stirring and reacting for 1 hour, stopping introducing nitrogen, stopping stirring at the same time, cooling to room temperature, placing the product in the three-neck flask into a dialysis bag with molecular weight cut-off of 5000, placing into deionized water for cleaning, taking out the sample in the dialysis bag for rotary evaporation and freeze drying when the pH of the solution is about 7.
(2) 1 g of the reaction product obtained in the step (1) is added with water to prepare a 2wt% solution, then 0.2 g of 1, 4-butanediol diglycidyl ether is added, and after being stirred uniformly, the mixture is poured into a mold and put into a baking oven at 50 ℃ for 1 hour, and the moisturizing gel is prepared.
Example 3
The embodiment provides a preparation method of moisturizing gel, which comprises the following steps:
(1) Dissolving 15 g of guar gum into 80 g of water, adding the water into a three-neck flask, magnetically stirring the water by using a rotor, continuously introducing nitrogen into the three-neck flask after sealing the three-neck flask, keeping the water bath temperature at 60 ℃, adding 5 g of glycidyl methacrylate and 2 g of 10wt% of sodium carbonate aqueous solution, continuously introducing nitrogen to react for 2 hours, dropwise adding 0.5 g of 6-mercapto-1-hexanol into the three-neck flask, continuously introducing nitrogen, continuously using 365nm ultraviolet light to irradiate, continuously stirring the three-neck flask for 1 hour, stopping introducing nitrogen while stopping stirring, cooling to room temperature, filling the product in the three-neck flask into a dialysis bag with a molecular weight cut-off of 5000, cleaning the dialysis bag in deionized water, taking out a sample in the dialysis bag for rotary steaming and freeze drying when the pH of the solution is about 7.
(2) 1 g of the reaction product obtained in the step (1) is added with water to prepare a 2wt% solution, then 0.2 g of 1, 4-butanediol diglycidyl ether is added, and after being stirred uniformly, the mixture is poured into a mold and put into a baking oven at 50 ℃ for 1 hour, and the moisturizing gel is prepared.
Example 4
The embodiment provides a preparation method of moisturizing gel, which comprises the following steps:
(1) Dissolving 10 g of guar gum into 80 g of water, adding the water into a three-neck flask, using a rotor to stir magnetically, sealing the three-neck flask, continuously introducing nitrogen for 5 minutes, keeping the water bath temperature at 55 ℃, adding 10 g of glycidyl methacrylate and 2 g of 10wt% sodium carbonate aqueous solution, continuously introducing nitrogen to react for 2 hours, dropwise adding 0.5 g of HS-PEG-OH with the average molecular weight of 400 into the three-neck flask, continuously introducing nitrogen, using 365nm ultraviolet light to irradiate, continuously stirring and reacting for 1 hour, stopping introducing nitrogen while stopping stirring, cooling to room temperature, filling the product in the three-neck flask into a dialysis bag with the molecular weight cut-off of 5000, cleaning in deionized water, taking out a sample in the dialysis bag to perform rotary evaporation and freeze drying when the pH of the solution is about 7.
(2) 1 g of the reaction product obtained in the step (1) is added with water to prepare a 2wt% solution, then 0.2 g of ethylene glycol diglycidyl ether is added, and after being stirred uniformly, the mixture is poured into a mold and placed into an oven at 50 ℃ for 1 hour, thus obtaining the moisturizing gel.
Example 5
The embodiment provides a preparation method of moisturizing gel, which comprises the following steps:
(1) Dissolving 10 g of guar gum into 80 g of water, adding the water into a three-neck flask, magnetically stirring the water by using a rotor, continuously introducing nitrogen into the three-neck flask after sealing the three-neck flask, keeping the water bath temperature at 55 ℃, adding 15 g of glycidyl methacrylate and 2 g of 10wt% of potassium hydroxide aqueous solution, continuously introducing nitrogen to react for 2 hours, dropwise adding 0.5 g of mercaptoethylamine into the three-neck flask, continuously introducing nitrogen, continuously using 365nm ultraviolet light to irradiate, continuously stirring the water for 1 hour, stopping introducing nitrogen while stopping stirring, cooling the water to room temperature, filling the product in the three-neck flask into a dialysis bag with a molecular weight cut-off of 5000, cleaning the water in deionized water, taking out a sample in the dialysis bag for rotary steaming and freeze drying when the pH of the solution is about 7.
(2) 1 g of the reaction product obtained in the step (1) is added with water to prepare a 2wt% solution, then 0.2 g of glycerol triglycidyl ether is added, and after being stirred uniformly, the mixture is poured into a mold and placed into a baking oven at 50 ℃ for 1 hour, and the moisturizing gel is prepared.
Comparative example 1
The comparative example provides a method for preparing a moisturizing gel, comprising the following steps:
(1) Dissolving 10 g of hydroxyethyl cellulose into 80 g of water, adding the water into a three-neck flask, magnetically stirring the water by using a rotor, continuously introducing nitrogen into the three-neck flask after sealing the three-neck flask, keeping the water bath temperature at 50 ℃, adding 5 g of glycidyl methacrylate and 2 g of 10wt% sodium hydroxide aqueous solution, continuously introducing nitrogen for reaction for 2 hours, dropwise adding 0.5 g of mercaptoethylamine into the three-neck flask, continuously introducing nitrogen, using 365nm ultraviolet light for irradiation, continuously stirring the reaction for 1 hour, stopping introducing nitrogen while stopping stirring, cooling the reaction product to room temperature, loading the product in the three-neck flask into a dialysis bag with a molecular weight cut-off of 5000, cleaning the product in deionized water, taking out a sample in the dialysis bag for rotary steaming and freeze drying when the pH of the solution is about 7.
(2) 1 g of the reaction product obtained in the step (1) is added with water to prepare a 2wt% solution, then 0.2 g of 1, 4-butanediol diglycidyl ether is added, and after being stirred uniformly, the mixture is poured into a mold and put into a baking oven at 50 ℃ for 1 hour, and the moisturizing gel is prepared.
Comparative example 2
The comparative example provides a method for preparing a moisturizing gel, comprising the following steps:
1 g of guar gum is added with water to prepare a solution with the mass percent of 2wt% of the guar gum, then 0.2 g of 1, 4-butanediol diglycidyl ether is added, the mixture is stirred uniformly and poured into a mold, and the mold is put into an oven at 50 ℃ for 1 hour to prepare the moisturizing gel.
Comparative example 3
The comparative example provides a method for preparing a moisturizing gel, comprising the following steps:
(1) Dissolving 10 g of guar gum into 80 g of water, adding the water into a three-neck flask, magnetically stirring the water by using a rotor, continuously introducing nitrogen into the three-neck flask after sealing the three-neck flask, keeping the water bath temperature at 55 ℃, adding 15 g of 4-vinylbenzyl glycidyl ether and 2 g of 10wt% aqueous sodium hydroxide solution, continuously introducing nitrogen for reacting for 2 hours, dropwise adding 0.5 g of mercaptoethylamine into the three-neck flask, continuously introducing nitrogen, irradiating the water by using 365nm ultraviolet light, continuously stirring the water for 1 hour, stopping introducing nitrogen while stopping stirring, cooling the water to room temperature, filling the product in the three-neck flask into a dialysis bag with a molecular weight cut-off of 5000, cleaning the dialysis bag in deionized water, taking out a sample in the dialysis bag for rotary steaming and freeze drying until the pH of the solution is about 7.
(2) 1 g of the reaction product obtained in the step (1) is added with water to prepare a 2wt% solution, then 0.2 g of ethylene glycol diglycidyl ether is added, and after being stirred uniformly, the mixture is poured into a mold and placed into an oven at 50 ℃ for 1 hour, thus obtaining the moisturizing gel.
Experimental example 1
The moisturizing gels prepared in each example and comparative example were respectively freeze-dried to prepare xerogels, and each group of 1 gram of xerogels was put into water, and left stand for 24 hours, and the xerogels were saturated with water, weighed and recorded as M1. Then putting the xerogel into a baking oven at 40 ℃ for baking for 24 hours, weighing again, recording as M2, and calculating the water absorption= (M1-1 g)/1 g multiplied by 100%, and the water retention= (M2-1 g)/1 g multiplied by 100%; the results are shown in the following table.
TABLE 1 Water absorption and Water retention results
As shown in the above table, the water absorption rate of the moisturizing gel obtained in each example of the present invention is higher than 90% after standing for 24 hours, and the water retention rate of the moisturizing gel obtained in each example of the present invention is not lower than 60% after baking in an oven at 40 ℃ for 24 hours, and the moisturizing gel has good water absorption performance and moisturizing performance, while the moisturizing gels of comparative examples 1 to 3 have poor water absorption performance and moisturizing performance.
It is apparent that the above examples are given by way of illustration only and are not limiting of the embodiments. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. While still being apparent from variations or modifications that may be made by those skilled in the art are within the scope of the invention.

Claims (7)

1. The preparation method of the moisturizing gel is characterized by comprising the following steps of:
s1, step: reacting guar gum with glycidyl methacrylate under the action of a catalyst, wherein the catalyst is at least one of potassium hydroxide, sodium carbonate and potassium carbonate, the reaction temperature is 50-60 ℃ in the step S1, the reaction time is 2-10h, the mass ratio of the glycidyl methacrylate to the guar gum is 1:3-3:1, and in the step S1, water is used as a solvent for reaction;
s2, step: reacting the product of step S1 with a sulfhydryl compound selected from the group consisting of mercaptoethylamine, mercaptopropylamine, HS-PEG-NH under ultraviolet light 2 At least one of 3-mercapto-1-hexanol, 6-mercapto-1-hexanol, HS-PEG, 3-mercapto-1-propanol, and HS-PEG-OH; the mass of the sulfhydryl compound accounts for the mass of the glycidyl methacrylate3-10% in number, and in the step S2, the reaction temperature is 50-60 ℃ and the reaction time is 1-5h;
s3, step: mixing the product of the step S2 with a cross-linking agent, and heating to obtain a moisturizing gel, wherein the cross-linking agent is at least one selected from ethylene glycol diglycidyl ether, 1, 4-butanediol diglycidyl ether, 1, 6-hexanediol diglycidyl ether, polypropylene glycol diglycidyl ether, polyethylene glycol diglycidyl ether and glycerol triglycidyl ether; the cross-linking agent accounts for 0.1-5% of the glycidyl methacrylate by mass; in the step S3, the heating temperature is 40-60 ℃ and the time is at least 0.5 hour.
2. The method for preparing a moisturizing gel according to claim 1, wherein in the step S1, the reaction is performed under an atmosphere of nitrogen or inert gas.
3. The method for preparing a moisturizing gel according to claim 1, wherein the mass of the catalyst is 0.5% -5% of the mass of the glycidyl methacrylate.
4. The method for preparing a moisturizing gel according to claim 1, further comprising the steps of cooling, dialyzing and drying the reactant of the step S2.
5. The method for preparing a moisturizing gel according to claim 1, wherein in the step S2, the reaction is performed under an atmosphere of nitrogen or inert gas.
6. The method for preparing a moisturizing gel according to claim 1, wherein in the step S3, the reaction is performed using water as a solvent.
7. A moisturizing gel prepared by the method of any one of claims 1-6.
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