CN115399758A

CN115399758A - Detection system, method, equipment and storage medium based on optical waveguide sensor

Info

Publication number: CN115399758A
Application number: CN202110576310.8A
Authority: CN
Inventors: 汪远; 陆辉; 柏志飞; 褚浩宇; 陈敏
Original assignee: Nanjing Weina Technology Research Institute Co ltd
Current assignee: Nanjing Weina Technology Research Institute Co ltd
Priority date: 2021-05-26
Filing date: 2021-05-26
Publication date: 2022-11-29
Also published as: WO2022246979A1

Abstract

The embodiment of the invention provides a detection system, a method, equipment and a storage medium based on an optical waveguide sensor, wherein the system comprises a wearable sensing chip, a signal receiver and a health monitoring platform, the sensing chip comprises the optical waveguide sensor, the optical waveguide sensor is used for acquiring physiological index information of a user at preset time intervals or continuously and transmitting the physiological index information to the signal receiver, the signal receiver is used for analyzing and processing the received physiological index information and transmitting the processed information to the health monitoring platform, and the health monitoring platform is used for displaying the processed information.

Description

Detection system, method, equipment and storage medium based on optical waveguide sensor

Technical Field

The present invention relates to the field of sensing technologies, and in particular, to a detection system, method, device, and storage medium based on an optical waveguide sensor.

Background

With the continuous improvement of living standard, users pay more attention to their health conditions. Regular health examinations may help users understand their health status and early diagnosis of some diseases.

Present health physical examination needs the user to go to the hospital and carries out specific physical examination project, or utilizes some simple and easy health detection equipment of domestic formula to carry out the measurement of specific physiological index, and complex operation wastes time and energy, and monitoring effect is relatively poor.

Disclosure of Invention

The embodiment of the invention provides a detection system, a method, equipment and a storage medium based on an optical waveguide sensor, which can detect continuous physiological index values of a user, are convenient and fast to operate, save time and have a good monitoring effect.

In a first aspect, an embodiment of the present invention provides a detection system based on an optical waveguide sensor, where the system includes:

the system comprises a wearable sensing chip, a signal receiver and a health monitoring platform;

the sensing chip comprises an optical waveguide sensor, and the optical waveguide sensor is used for acquiring physiological index information of a user at preset time intervals or continuously and transmitting the physiological index information to a signal receiver;

the signal receiver is used for analyzing and processing the received physiological index information and sending the processed information to the health monitoring platform;

the health monitoring platform is used for displaying the processed information.

Optionally, the optical waveguide sensor includes: the device comprises an excitation light source, a first lens, a first optical waveguide, an optical sensing module, a second optical waveguide, a second lens and a photoelectric detection device;

the excitation light source is used for outputting optical signals, and the optical signals are converged to the first optical waveguide through the first lens;

the first optical waveguide is connected with the optical sensing module, and the optical sensing module is used for transmitting an optical signal output by the first optical waveguide to a detected part, acquiring an optical response signal obtained after the optical signal acts on the detected part, and transmitting the obtained optical response signal to the second optical waveguide;

the second optical waveguide is used for converging the acquired optical response signal to the photoelectric detection device through a second lens;

the photoelectric detection device is used for determining corresponding physiological index information according to the acquired optical response signal.

Optionally, the optical sensing module includes: a wavelength division multiplexing module and at least one detection component;

the first end of the wavelength division multiplexing module is connected with the first optical waveguide and is used for transmitting the optical signal of at least one wavelength acquired from the first optical waveguide to the second end;

each detection component comprises a third optical waveguide and an optical sensing layer, wherein the third optical waveguide is connected with the second end of the wavelength division multiplexing module and is used for transmitting the optical signal acquired from the second end to the detected part;

the optical sensing layer is used for collecting an optical response signal obtained after the optical signal acts on the detected part and transmitting the obtained optical response signal to the second optical waveguide through the third optical waveguide and the wavelength division multiplexing module.

Optionally, the optical waveguide sensor is configured to detect one or more items of physiological index information; a corresponding detection component and a photoelectric detection device are arranged for each item of physiological index information.

Optionally, the physiological index information includes at least one of: cholesterol, low density lipoprotein, uric acid, urea, creatinine, glucose, catecholamine, acetylcholine, theophylline, pH, lactic acid, sialic acid, active oxygen, sodium ion, potassium ion, glutamic-pyruvic transaminase, alkaline phosphatase, carcinoembryonic antigen, and alpha-fetoprotein.

Optionally, the optical response signal is used to indicate at least one of: the light absorption is enhanced or weakened, the light scattering is enhanced or weakened, the fluorescence is enhanced or quenched, a Raman scattering peak is generated, and a surface plasmon resonance peak moves.

Optionally, the sensing chip further includes: and the signal calibration unit is used for calibrating the physiological index information acquired by the optical waveguide sensor.

Optionally, the sensing chip further includes at least one of: a temperature sensor, a humidity sensor, a timer and an ion concentration sensor;

correspondingly, the signal calibration unit is specifically configured to perform at least one of the following on the physiological index information acquired by the optical waveguide sensor:

the method comprises the following steps of temperature calibration, humidity calibration, optical sensing layer oxidation calibration, optical sensing layer thermal degradation calibration, optical sensing layer photobleaching calibration, optical sensing layer photo-activation calibration after oxidation, optical sensing layer photobleaching calibration after thermal degradation, and ion concentration calibration.

Optionally, the calibration coefficient used for calibrating the physiological index information is a calibration coefficient determined based on a material of the optical sensing layer.

Optionally, the sensing chip further includes: and the signal transmitting circuit is used for transmitting the calibrated physiological index information to the signal receiver.

Optionally, the signal receiver is specifically configured to perform at least one of normalization, prediction, and drawing of a change map on the received physiological index information, and send the processed information to the health monitoring platform.

Optionally, when the signal receiver performs the prediction processing on the physiological index information, the signal receiver is specifically configured to:

the physiological index information is predicted based on the neural network through the wearing position and the temperature information of the sensing chip and the physiological index information obtained through history.

Optionally, the health monitoring platform comprises at least one of:

the information sharing platform is used for displaying the processed information for the tested user and the associated user;

the health information base is used for storing at least one of the following information of the tested user: personal basic information, change information of physiological index information, associated information with associated users, regional information, age and work attributes;

the system comprises an information system applied to a hospital, a database and a database server, wherein the information system is used for medical staff to access at least part of information of a tested user under the authorization of the tested user, and/or adding medical order information in a personal information base of the tested user.

Optionally, the information system applied to the hospital includes a device provided in the hospital for printing the personal health information.

Optionally, the health monitoring platform is further configured to:

and acquiring the permission set by the tested user for the associated user, and displaying information to the associated user based on the permission.

In a second aspect, an embodiment of the present invention provides a method applied to a signal receiver, where the method includes:

acquiring physiological index information sent by a wearable sensing chip, wherein the physiological index information is acquired at intervals of preset time or continuously acquired on the basis of an optical waveguide sensor in the sensing chip;

analyzing and processing the received physiological index information, and sending the processed information to a health monitoring platform so that the health monitoring platform displays the processed information.

Optionally, analyzing and processing the received physiological index information includes:

and carrying out at least one of normalization, prediction and change graph drawing on the received physiological index information.

Optionally, predicting the received physiological index information includes:

Optionally, the physiological index information includes at least one of: cholesterol, low density lipoprotein, uric acid, urea, creatinine, glucose, catecholamine, acetylcholine, theophylline, pH, lactic acid, sialic acid, active oxygen, sodium ion, potassium ion, glutamic-pyruvic transaminase, alkaline phosphatase, carcinoembryonic antigen, alpha-fetoprotein.

Optionally, the physiological index information is obtained based on at least one of optical absorption detection, optical scattering detection, fluorescence detection, raman detection, and surface plasmon resonance detection.

Optionally, the received physiological index information is specifically information obtained by calibrating the physiological index information detected by the optical waveguide sensor through a signal calibration unit of the sensing chip.

In a third aspect, an embodiment of the present invention provides another method, which is applied to a health monitoring platform, where the method includes:

receiving information obtained by analyzing and processing the physiological index information by a signal receiver, wherein the physiological index information is acquired at intervals of preset time or continuously acquired based on an optical waveguide sensor in a sensing chip;

and displaying the information obtained after the analysis processing.

Optionally, displaying information obtained after the analysis processing includes:

and displaying the analyzed and processed information for the tested user and the associated user.

Optionally, the method further includes:

storing at least one of the following information of the tested user: personal basic information, change information of physiological index information, associated information with associated users, regional information, age and work attributes; and/or the presence of a gas in the atmosphere,

displaying at least part of information of the tested user to medical staff under the authorization of the tested user; and/or the presence of a gas in the gas,

acquiring medical order information input by medical staff and adding the medical order information into a personal information base of a tested user.

Optionally, the method further includes:

and acquiring the authority set by the tested user for the associated user, and displaying information to the associated user based on the authority.

In a fourth aspect, an embodiment of the present invention provides a detection apparatus based on an optical waveguide sensor, where the apparatus includes:

the system comprises an acquisition module, a processing module and a display module, wherein the acquisition module is used for acquiring physiological index information sent by a wearable sensing chip, and the physiological index information is acquired at preset time intervals or continuously acquired on the basis of an optical waveguide sensor in the sensing chip;

the first display module is used for analyzing and processing the received physiological index information and sending the processed information to the health monitoring platform so that the health monitoring platform can display the processed information.

In a fifth aspect, an embodiment of the present invention provides a detection apparatus based on an optical waveguide sensor, where the apparatus includes:

the receiving module is used for receiving information obtained after the signal receiver analyzes and processes the physiological index information, wherein the physiological index information is acquired at intervals of preset time or continuously acquired on the basis of an optical waveguide sensor in the sensing chip;

and the second display module is used for displaying the information obtained after the analysis processing.

In a sixth aspect, an embodiment of the present invention provides a signal receiving apparatus, including: at least one processor and a memory;

the memory stores computer-executable instructions;

the at least one processor executing the computer-executable instructions stored by the memory causes the at least one processor to perform the optical waveguide sensor-based detection method of any of the second aspects above.

In a seventh aspect, an embodiment of the present invention provides a monitoring device, including: at least one processor and memory;

the memory stores computer-executable instructions;

the at least one processor executing the computer-executable instructions stored by the memory causes the at least one processor to perform the method of optical waveguide sensor-based detection as described in any of the third aspects above.

In an eighth aspect, the embodiments of the present invention provide a computer-readable storage medium, in which computer-executable instructions are stored, and when the computer-executable instructions are executed by a processor, the computer-executable instructions are configured to implement the method according to any one of the second aspect and the third aspect.

In a ninth aspect, an embodiment of the present invention provides a computer program product, which includes a computer program that, when executed by a processor, implements the method according to any one of the second and third aspects.

The detection system, the method, the equipment and the storage medium based on the optical waveguide sensor comprise a wearable sensing chip, a signal receiver and a health monitoring platform, wherein the sensing chip comprises the optical waveguide sensor, the optical waveguide sensor is used for acquiring physiological index information of a user at preset time intervals or continuously and sending the physiological index information to the signal receiver, the signal receiver is used for analyzing and processing the received physiological index information and sending the processed information to the health monitoring platform, and the health monitoring platform is used for displaying the processed information, can monitor the continuous physiological index information of the user with multiple indexes, detects various physiological indexes of the user in real time, and is simple to operate and good in monitoring effect.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and together with the description, serve to explain the principles of the invention.

Fig. 1 is a schematic view of an application scenario provided in an embodiment of the present invention;

fig. 2 is a schematic structural diagram of a monitoring system based on an optical waveguide sensor according to an embodiment of the present invention;

fig. 3 is a schematic structural diagram of an optical waveguide sensor according to an embodiment of the present invention;

fig. 4 is a schematic view of a wearing manner of a sensor chip according to an embodiment of the present invention;

FIG. 5 is a schematic diagram illustrating an effect factor on an optical sensing layer according to an embodiment of the present invention;

FIG. 6 is a graph showing the change of fluorescence spectrum of phenylboronic acid derivatives with glucose concentration according to an embodiment of the present invention;

FIG. 7 is a graph showing the variation of fluorescence intensity of phenylboronic acid derivatives with blood glucose concentration according to an embodiment of the present invention;

FIG. 8 is a graph showing the variation of fluorescence peak intensity of phenylboronic acid derivatives with blood glucose concentration according to an embodiment of the present invention;

FIG. 9 is a flow chart of a detection process based on an optical waveguide sensor according to an embodiment of the present invention;

FIG. 10 is a flow chart of another optical waveguide sensor-based detection method according to an embodiment of the present invention;

FIG. 11 is a schematic diagram of a detection principle of an optical waveguide sensor according to an embodiment of the present invention;

fig. 12 is a schematic structural diagram of a detecting device based on an optical waveguide sensor according to an embodiment of the present invention;

FIG. 13 is a schematic structural diagram of another optical waveguide sensor-based detection apparatus according to an embodiment of the present invention;

fig. 14 is a schematic structural diagram of a signal receiving apparatus according to an embodiment of the present invention;

fig. 15 is a schematic structural diagram of a monitoring device according to an embodiment of the present invention.

With the above figures, certain embodiments of the invention have been illustrated and described in more detail below. The drawings and the description are not intended to limit the scope of the inventive concept in any way, but rather to illustrate it by those skilled in the art with reference to specific embodiments.

Detailed Description

Reference will now be made in detail to the exemplary embodiments, examples of which are illustrated in the accompanying drawings. The following description refers to the accompanying drawings in which the same numbers in different drawings represent the same or similar elements unless otherwise indicated. The implementations described in the following exemplary examples do not represent all implementations consistent with the present invention. Rather, they are merely examples of apparatus and methods consistent with certain aspects of the invention, as detailed in the appended claims.

The following describes the technical solution of the present invention and how to solve the above technical problems in detail by specific examples. The following several specific embodiments may be combined with each other, and details of the same or similar concepts or processes may not be repeated in some embodiments.

The following explains an application scenario provided by an embodiment of the present invention: the scheme provided by the embodiment of the invention relates to the monitoring of the physiological indexes of the user. It is now common that the user needs to go to the hospital for a specific physical examination item, such as blood routine, urinalysis, cancer cell screening, electrocardiogram, electroencephalogram, etc. In the case of simpler testing items, a home-use, simple health monitoring device may be selected. Common household health detection devices include a sphygmomanometer, a blood glucose meter and a heart rate monitor, and the devices can help a user to measure some physiological indexes at home.

In some technologies, a user needs to go to a hospital to check some physical examination items, the physical examination mode needs good compliance of the user, generally the examination is performed at least once a year, which is difficult to realize in a region with poor medical resources, and the frequency of the physical examination once a year is difficult to realize the early diagnosis of diseases.

In other techniques, a home-based simple health-monitoring device may help a user to check some physiological indicators without going to a hospital. However, the physical indicators monitored by the household health examination equipment are limited, and some diseases cannot be discovered at an early stage.

The two health physical examination methods measure the physiological index information of a user at a certain time point, do not have the function of continuous monitoring, and are difficult to truly reflect the health level and the later-stage physiological index development trend of the user.

Therefore, the embodiment of the invention provides a detection system based on an optical waveguide sensor, the optical waveguide sensor can detect continuous physiological index information and transmit the information to a signal receiver, the signal receiver analyzes and processes the information and transmits the processed information to a health detection platform, the health detection platform can display the information, the continuous physiological index information of a user can be detected, the operation is convenient and fast, the time is saved, and the monitoring effect is improved.

Fig. 1 is a schematic view of an application scenario provided in an embodiment of the present invention. As shown in fig. 1, a measurement of heart rate may optionally be made at the wrist of the user with the health monitoring device 100. The monitoring device 100 adopts an electro-optical method to measure the heart rate of the user, and the contraction and the relaxation of the heart can enable the blood vessels to shrink and expand regularly, so that the reflection of light fluctuates, the heart rate value of the user can be measured, and the heart rate of the user can be monitored continuously.

Some embodiments of the invention are described in detail below with reference to the accompanying drawings. The features of the embodiments and examples described below may be combined with each other without conflict between the embodiments.

Fig. 2 is a schematic structural diagram of a monitoring system based on an optical waveguide sensor according to an embodiment of the present invention. As shown in fig. 2, the system in the present embodiment includes: wearable sensing chip, signal receiver and health monitoring platform.

The sensing chip comprises an optical waveguide sensor, the optical waveguide sensor is used for acquiring physiological index information of a user at preset time intervals or continuously and transmitting the physiological index information to a signal receiver, the signal receiver is used for analyzing and processing the received physiological index information and transmitting the processed information to a health monitoring platform, and the health monitoring platform is used for displaying the processed information.

The sensing chip can be a health sensing chip, and a user can wear the sensing chip aiming at one or more physiological indexes according to personal wishes. The implantation position of the sensing chip can be a certain part of a body which is conveniently implanted by a user, and particularly can be positioned on the back, the abdomen, the outer side of thighs, the inner side of shanks, the neck, the outer side of arms and the like of the user. Due to different working modes of the optical waveguide sensor, the sensing chip can be worn on a certain part of the body of a user in an implanted mode, a puncture mode or a non-invasive mode. Optionally, the sensing chip may further include other circuit portions, such as a central processing unit, a photoelectric conversion circuit, an operational amplifier circuit, and a charging circuit.

Alternatively, the optical waveguide sensor may be made of a flexible material having high chemical stability, for example, polydimethylsiloxane may be used. Optical waveguide sensor through flexible material preparation is at the actual work in-process, will pierce the position that user subcutaneous tissue interstitial fluid degree of depth is less than 4 millimeters, and at the time of predetermineeing or gather different physiological index information in succession to the physiological index information that will gather sends information receiver through sensor chip, can ensure that the user does not have the perception at the in-process of wearing, makes the user more comfortable wearing the in-process, does not influence user's action activity.

In the embodiment of the invention, the optical waveguide sensor is used for acquiring the physiological index information of the user at intervals of preset time or continuously and sending the physiological index information to the signal receiver.

In an optional implementation manner, the optical waveguide sensor may collect physiological index information of the user at preset time intervals and send the physiological index information to the signal receiver.

The preset time may be a detection interval time set manually. Specifically, the preset time may be 3 minutes, 5 minutes, or 10 minutes.

In another optional implementation manner, the optical waveguide sensor may continuously and uninterruptedly acquire the physiological index information of the user and send the physiological index information to the signal receiver, and the signal receiver continuously receives the physiological index information, so as to implement a real-time and continuous health monitoring function and improve a monitoring effect.

Optionally, the signal receiver may be a device capable of communicating, specifically, an independent signal receiving device, or a terminal device such as a mobile phone. When the signal receiver is an independent signal receiving device, the communication mode of the signal receiver comprises a wired transmission technology, a zigbee technology, a near field communication technology, a radio frequency identification technology, a bluetooth technology, a Wi-Fi technology and the like, and when the signal receiver is a mobile phone terminal, a mobile phone with bluetooth can be used for communicating with the health sensing chip through bluetooth, or the mobile phone can be used for communicating with the independent signal receiving device through bluetooth, so that the signal sent by the sensor is directly or indirectly received through the mobile phone. Correspondingly, both the application program and the mobile phone software on the independent signal receiving equipment can receive the physiological index information sent by the sensing chip, analyze and process the information and send the processed information to the health monitoring platform. The process of the analytical process may include, but is not limited to: filtering, analog-to-digital conversion, denoising, calibrating, normalizing, predicting, modulating and other arbitrary information processing processes.

Optionally, the health monitoring platform may exist independently of the sensing chip provided by the present invention, and the platform may display continuous physiological index information provided by other types of sensing chips. For example, the health monitoring platform can display the acquired data by adding a data transmission interface to the health sensors of a household blood glucose meter, a sphygmomanometer, a temperature sensor, physical examination data at a hospital end and the like and transmitting the data to the health monitoring platform.

In practical applications, the detection system provided by the embodiment can be realized through hardware improvement. Optionally, the optical waveguide sensor may be implemented by an optical waveguide and a photoelectric detection device, the obtained physiological index information may be represented as a voltage signal or a current signal, the sensing chip may be connected to the signal receiver, and the signal receiver obtains the signal acquired by the sensing chip and performs analysis processing. The analysis processing procedure may be implemented by using relevant hardware, for example, algorithms such as calibration, normalization and the like are performed on the signals, the algorithms may be implemented by setting selectors, adders, multipliers and the like, the signals are processed by a neural network, and the algorithms may be implemented by a convolution operation array and the like. The health monitoring platform can be connected with the signal receiver, can receive and display the processed signals sent by the signal receiver, and the display mode can also be realized through a hardware structure, such as an LED nixie tube, an indicator light, a loudspeaker and the like.

The detection system provided by the embodiment of the invention comprises a wearable sensing chip, a signal receiver and a health monitoring platform, wherein the sensing chip comprises an optical waveguide sensor, the optical waveguide sensor is used for acquiring physiological index information of a user at preset time intervals or continuously and transmitting the physiological index information to the signal receiver, the signal receiver is used for analyzing the received physiological index information and transmitting the processed information to the health monitoring platform, and the health monitoring platform is used for displaying the processed information, can monitor the continuous physiological index information of the user with multiple indexes and detects various physiological indexes of the user in real time, and is simple to operate and good in monitoring effect.

Based on the technical solutions provided by the above embodiments, fig. 3 is a schematic structural diagram of an optical waveguide sensor provided by an embodiment of the present invention. As shown in fig. 3, the optical waveguide sensor includes:

the device comprises an excitation light source 1, a first lens 2, a first optical waveguide 3, an optical sensing module 50, a second optical waveguide 7, a second lens 8 and a photoelectric detection device 9; the excitation light source 1 is configured to output an optical signal, and the optical signal is converged to the first optical waveguide 3 through the first lens 2; the first optical waveguide 3 is connected to the optical sensing module 50, and the optical sensing module 50 is configured to transmit an optical signal output by the first optical waveguide 3 to a detected part, collect an optical response signal obtained after the optical signal is acted by the detected part, and transmit the obtained optical response signal to the second optical waveguide 7; the second optical waveguide 7 is used for converging the acquired optical response signal to a photoelectric detection device 9 through a second lens 8; the photoelectric detection device 9 is used for determining corresponding physiological index information according to the acquired optical response signal.

The photodetector 9 may include a photodetector or a spectrometer, and may implement photoelectric conversion. The photodetector or spectrometer includes a signal light detection subunit and a reference light detection subunit, the signal light detection subunit selecting different wavelength bands according to optical characteristics of the analyte, and selecting one or more signal light photoelectric detection subunits according to the number of detection indexes. The signal light detection subunit may also be referred to as a signal light photodetection subunit.

Alternatively, the optical signal may be a plurality of laser beams with different wavebands emitted by the excitation light source.

In the figure the dashed arrows indicate the direction of optical signal transmission and the solid arrows indicate the direction of optical response signal transmission.

In the embodiment of the invention, the implementation mode of sensing is different from most electrochemical methods, an optical detection method based on an optical waveguide technology is creatively adopted, and the optical waveguide technology has the advantages of strong anti-electromagnetic interference capability, good electrical insulation performance, safety and reliability, and can improve the accuracy of detecting the physiological index information.

Optionally, the optical sensing module 50 includes: a wavelength division multiplexing module 4 and at least one detection component 40;

a first end of the wavelength division multiplexing module 4 is connected to the first optical waveguide 3, and is configured to transmit an optical signal of at least one wavelength acquired from the first optical waveguide 3 to a second end; each detection component 40 comprises a third optical waveguide 10 and an optical sensing layer 6, wherein the third optical waveguide 10 is connected with the second end of the wavelength division multiplexing module and is used for transmitting the optical signals acquired from the second end to the detected part; the optical sensing layer 6 is configured to collect an optical response signal obtained after an optical signal is acted by the measured portion, and transmit the obtained optical response signal to the second optical waveguide 7 through the third optical waveguide 10 and the wavelength division multiplexing module 4.

The wavelength division multiplexing module 4 may be a wavelength division multiplexing module with two or more wavelength division multiplexing modules. The wavelength division multiplexing module 4 may combine a plurality of optical signals with different wavelengths transmitted by the first optical waveguide 3 into a bundle, transmit the bundle along a single optical fiber, and transmit the bundle to the third optical waveguide 10. The third optical waveguide 10 transmits the optical response signal generated by transmitting the optical signal to the detected portion to the wavelength division multiplexing module 4, and the wavelength division multiplexing module 4 divides the optical signal according to the wavelength and transmits the optical signal to the second optical waveguide 7.

Wherein each optical sensing layer 6 corresponds to a different detection index, in order to distinguish different optical sensing layers 6, fig. 3 schematically illustrates different optical sensing layers 6 separately, and it can be understood that, in practical application, different optical sensing layers 6 are tied together. There may be multiple optical sensing layers 6 in each optical waveguide sensor.

Optionally, after the optical sensing layer 6 collects the optical signal guided to the third optical waveguide 10, one or more physiological indexes are selectively captured according to different types of the optical sensing layer 6, and then an optical response signal is generated.

In this embodiment, the optical waveguide technology ensures efficient excitation and collection efficiency, can improve the signal-to-noise ratio, efficiently excites the optical signal to the optical sensing layer, and can efficiently transmit the optical signal to the photodetection device 9.

In other alternative implementations, the optical sensing module may omit the wavelength division multiplexing module, or use other forms of sensing modules, as long as it is capable of detecting the optical response signal carrying the detected location information.

Wherein, the optical waveguide sensor can detect at least one item of physiological index information. Each optical sensing layer in the optical waveguide sensor can correspondingly detect optical response information and send the detected optical response information to the corresponding photoelectric detection device, and the photoelectric detection device can determine corresponding physiological index information according to the optical response information.

When the detection component is provided with a plurality of optical sensing layers, a plurality of items of physiological index information can be correspondingly detected.

In this embodiment, the optical waveguide sensor is used to obtain at least one item of physiological index information, and the corresponding detection component and the photoelectric detection device are used to complete the detection of each physiological index, so as to accurately obtain each physiological index information.

The optical sensing layer can be used for detecting different physiological index information according to different types of the optical sensing layer. According to the quantity classification of the detection indexes, the sensing chip can be divided into single index detection and multi-index detection. The single index detection is that the sensing chip can detect single physiological index information, and the multi-index detection is that the sensing chip can detect a plurality of physiological index information simultaneously.

Optionally, by changing the material of the optical sensing layer, different health indicators can be detected by using the wavelength division multiplexing module, for example, blood glucose and cholesterol can be detected simultaneously. According to one embodiment of the present invention, one optical sensing layer may use phenylboronic acid derivative hydrogel, while the other optical sensing layer uses digitonin derivative hydrogel. After the two optical sensors capture two objects to be detected, the photoelectric detection module can detect optical response signals caused by blood sugar and cholesterol.

In this embodiment, compared with a common electrochemical detection method, the optical waveguide sensor has parallel multi-path detection capability, and different physiological index information can be detected simultaneously by using materials of different optical sensing layers, so that the detection efficiency is greatly improved, and the cost is saved.

Optionally, the optical response signal is used to indicate at least one of: the light absorption is enhanced or weakened, the light scattering is enhanced or weakened, the fluorescence is enhanced or quenched, a Raman scattering peak is generated, and a Surface Plasmon Resonance (SPR) peak is moved.

The detection mode of the sensing chip can be classified according to the optical sensing principle, and can be optical absorption detection, optical scattering detection, fluorescence detection, raman detection, surface plasmon resonance detection and the like, when the optical sensing layer captures corresponding physiological index information, the corresponding optical response change can be light absorption enhancement or reduction, light scattering enhancement or reduction, fluorescence enhancement or fluorescence quenching, raman scattering peak generation, surface plasmon resonance peak movement and the like.

Specifically, when the blood glucose concentration is detected, the phenylboronic acid derivative hydrogel can be used as an optical sensing layer, the phenylboronic acid derivative is used for specifically capturing glucose molecules, and after the glucose molecules are captured, the phenylboronic acid derivative can generate intramolecular photoinduced electron transfer to generate a fluorescence enhancement signal. And transmitting the fluorescent signal to a photoelectric detection device by using an optical waveguide, and detecting the fluorescent signal. When the fluorescent signal changes, it correspondingly indicates that the blood glucose concentration of the user is changing.

Optionally, the optical detection technique may be not only a fluorescence spectroscopy technique but also a raman scattering spectroscopy technique. Taking blood sugar measurement as an example, when a glucose molecule binds to a phenylboronic acid derivative, a new raman peak appears, and the intensity of the new raman peak is measured by a spectrometer, so that the blood sugar level is predicted.

Different optical response changes are obtained according to different detection modes of the sensing chip. When the detection mode is selected, the detection mode which can most represent the change of the physiological index information can be selected.

Optionally, when detecting the physiological index information, the optical waveguide sensor may be affected by a plurality of influencing factors, and may be calibrated by the signal calibration unit.

The signal calibration unit can calibrate the physiological index information according to the wearing position of the sensing chip.

Fig. 4 is a schematic view of a wearing manner of a sensor chip according to an embodiment of the present invention. As shown in fig. 4, the user can wear the sensing chip on the outer side of the arm, the optical waveguide sensor 11 monitors the physiological index information of the user at intervals or continuously, and the signal calibration unit 13 calibrates the physiological index information monitored by the optical waveguide sensor 11. The sensor chip housing 12 may protect the internal construction of the sensor chip. Optionally, the sensing chip may also be worn at other locations. The sensor chip has options of different wearing positions, and the sensor can select different calibration algorithms according to different wearing positions to calibrate the physiological index information.

Optionally, the signal calibration unit may also calibrate the physiological index information according to other external influence factors.

The detection accuracy can be improved by optimizing the structure of the optical waveguide sensor and compensating a plurality of calibration algorithms, and accurate and continuous physiological index information can be obtained.

the method comprises the following steps of temperature calibration, humidity calibration, optical sensing layer oxidation calibration, optical sensing layer thermal degradation calibration, optical sensing layer photobleaching calibration, optical sensing layer photo-activation calibration after oxidation, optical sensing layer photo-bleaching calibration after thermal degradation, and ion concentration calibration.

The temperature sensor in the sensing chip collects the temperature in the detection process, and the temperature calibration unit in the corresponding signal calibration unit calibrates the temperature collected by the temperature sensor. Specifically, when the temperature collected by the temperature sensor is too high or too low, the temperature calibration unit calibrates the detected physiological index information according to the temperature.

Humidity in the humidity sensor collection testing process among the sensor chip, humidity calibration unit calibrates the humidity that humidity sensor gathered in the corresponding signal calibration unit. The ion concentration sensor in the sensing chip collects the ion concentration in the detection process, and the ion concentration calibration unit in the corresponding signal calibration unit calibrates the ion concentration collected by the ion concentration sensor.

Optionally, the optical sensing layer oxidation calibration, the optical sensing layer thermal degradation calibration, the optical sensing layer photobleaching calibration, the optical sensing layer photo-activation calibration after oxidation, the optical sensing layer photo-bleaching calibration after oxidation, and the optical sensing layer photo-bleaching calibration after thermal degradation can respectively calibrate oxidation, thermal degradation, photo-bleaching, photo-activation, and the like, which are received by the optical sensing layer.

The optical sensing layer oxidation calibration is the calibration considering oxidation factors, the photobleaching calibration after the optical sensing layer oxidation is the calibration considering oxidation and photobleaching factors, the other calibration meanings are similar, and the calibration of different factors can be considered and set according to the practical application condition.

Various factors are comprehensively considered, and corresponding calibration methods are selected according to different factors, so that the accuracy of the detection data can be improved.

Optionally, the calibration coefficient for calibrating the physiological index information is a calibration coefficient determined based on a material of the optical sensing layer.

Different signal calibration algorithms can be correspondingly set according to the material characteristics of different optical sensing layers. Fig. 5 is a schematic diagram illustrating a factor affecting an optical sensing layer according to an embodiment of the present invention. As shown in fig. 5, when the optical waveguide sensor employs fluorescence detection, the optical sensing layer is affected by temperature, use time, cumulative light exposure time, and the like, and changes such as thermal degradation, oxidation, photobleaching, and the like occur. These 3 factors affect different optical sensing layer materials to different extents, so that different signal calibration coefficients need to be selected. After the optical waveguide sensor sets a test target, the system can automatically match the corresponding calibration coefficient, and the normalized fluorescence intensity is more accurately output. After the signal receiver receives the fluorescence intensity at a certain moment, the data self-learning is carried out according to the implantation position of the sensor, the temperature change and the data obtained at the previous moment, and then the physiological index information at the moment is predicted.

Because the optical sensing layer is influenced by temperature, humidity, oxidation, thermal degradation, photobleaching, photoactivation and ion concentration, different calibration algorithms can be compiled for different material characteristics of the optical sensing layer, a corresponding calibration system can be automatically matched according to a test target, and an optical response change value can be accurately output.

The calibration coefficient may be added to, multiplied by, exponential, logarithmic, etc. with the physiological index information to obtain calibrated physiological index information, and the specific calibration algorithm may be determined through experiments.

Optionally, the signal calibration unit automatically matches the corresponding calibration coefficient according to the position where the optical waveguide sensor is worn and/or the detection target of the optical sensing layer, calibrates the physiological index information according to the calibration coefficient, and outputs the calibrated physiological index information. The signal transmitting circuit can be connected with the signal calibration unit and outputs the calibrated one or more physiological index information to the signal receiver.

The calibrated physiological index information is sent to the signal receiver through the signal transmitting circuit, and the physiological index information transmitted to the signal receiver is guaranteed to be closest to the actual condition.

The signal receiver has a data processing function and can normalize all physiological index information to obtain the change of the physiological index data in the range of 0-1. According to the obtained certain physiological index information, a change chart can be drawn on the information, for example, the change condition of the physiological index information along with time is shown.

By analyzing and processing the physiological index information, the change trend of the physiological index information can be obtained, which is beneficial for a user to know a certain physiological index.

According to the wearing position of the sensing chip, the temperature information and the historical information, the information of a certain physiological index can be predicted through the neural network model, the future change value of the index can be judged, and the precaution consciousness can be improved.

Optionally, the health monitoring platform comprises at least one of:

the health information base is used for storing at least one item of the following information of the tested user: personal basic information, change information of physiological index information, associated information with associated users, regional information, age and work attributes;

the system comprises an information system applied to a hospital, a server and a server, wherein the information system is used for providing medical staff with access to at least part of information of a tested user under the authorization of the tested user, and/or adding medical order information in a personal information base of the tested user.

Optionally, the existing home health monitoring devices are usually only used as independent detection devices, and most of the existing home health monitoring devices cannot share information among family members through the internet, and further do not establish a comprehensive personal health information base containing personal information and various physiological indexes, and cannot access and modify the information base at a hospital end.

After artificial intelligence first year, the intelligent health monitoring platform starts, but most of the information of hospitals cannot be shared, and the condition that all examinations of a hospital need to be done again when the hospital is changed frequently occurs, so that the efficiency of the hospital is low, and patients repeatedly occupy medical resources; moreover, the household medical equipment in the prior art cannot realize information sharing among family members, so that the problem that a child currently far away from a parent cannot know the physical health condition of the parent in time cannot be well solved; meanwhile, for chronic diseases, which are diseases requiring continuous conditioning, long-term continuous intervention therapy is very necessary, but the lack of information sharing between hospital-side information and home-use medical equipment makes it difficult to realize. The health detection platform provided by the invention can realize partial information sharing between personal information and family and at a hospital.

Optionally, the information sharing platform may set an information sharing mode and a sharing authority. The information sharing mode can comprise selective information sharing among families and selective partial information sharing among patients and attending doctors. The setting of the sharing authority may include a setting that the user can perform the sharing authority according to the individual's needs.

Optionally, the information sharing platform further has an early warning function, and can give an early warning in time when the physiological index exceeds a threshold value. Specifically, the user A and the user B select information sharing, and both sides can see the physiological index information of the other side. When the blood pressure of the user A is higher, the user B can receive the early warning prompt of the higher blood pressure of the user A at the signal receiver end. The function can help the children in different places to know the physical condition of the parents in time.

Optionally, the health information base may be a personal health information base, including personal basic information of the user, changes of various physiological indexes of the user, associations between relatives and friends, associations between user regions, working properties, age groups, and big data analysis of health conditions of each user, a targeted personalized health management method, access right setting, and user-defined access rights. And the connection is established, so that the real reasons of the disease treatment of the user can be analyzed by the big data, the prevention or treatment can be performed in a targeted manner, and government control is facilitated, such as confirmation of environmental pollution disease, bad life disease and the like.

The hospital-side information system comprises partial information which is set in a hospital and can access the health information base under the condition that a tested person allows, and medical staff have the permission to add medical advice in the health information base.

The health information of the user can be selectively shared among relatives and friends, one account can be shared among family members, one account can be shared among each person, a personal health information base and a family information base can be established by the system, the different information bases are connected through big data analysis, the information can be accessed at a hospital end, and part of experts can be used for researching regional and health differences of all ages, so that government control is facilitated, and if the disease is determined to be environmental pollution, or bad life, the disease is determined to be the same.

The health monitoring platform can establish a personal health information base of a user, realizes partial information sharing with family members through the Internet, and helps the user to know own physical condition, help medical staff to accurately judge the cause of disease and improve the working efficiency with the partial information sharing of a hospital end.

The hospital end is provided with the equipment special for printing the personal health information, so that a user can conveniently carry the personal health information table when seeing a doctor in the hospital, and the judgment of medical staff on the etiology is facilitated.

Optionally, the health monitoring platform is further configured to:

The tested user can selectively share the health information with others, and can also set access authority for partial information. When the tested user is bound with the associated user, the tested user can set the authority to display partial personal information to the associated user. Specifically, the tested user may set that other people cannot view the blood glucose concentration of the user, and the associated user cannot access the blood glucose concentration of the tested user, but other physiological index information may still be viewed.

The tested user can protect the privacy of the tested user by setting the sharing authority, and partial information can be shared with others.

An alternative embodiment of the invention is given below by way of example of blood glucose. The phenylboronic acid derivative is used for specifically capturing glucose molecules, the phenylboronic acid derivative hydrogel is used as an optical sensing layer, and after the glucose molecules are captured, intramolecular photoinduced electron transfer can occur in the phenylboronic acid derivative, so that a fluorescence enhancement signal is generated. And transmitting the fluorescence signal to a photoelectric detection module by using an optical waveguide, and detecting the original fluorescence signal. The raw fluorescence signal is the physiological index information detected by the optical waveguide sensor before being processed by the signal calibration unit.

FIG. 6 is a graph showing the change of fluorescence spectrum of phenylboronic acid derivatives with glucose concentration according to an embodiment of the present invention. As shown in fig. 6, the fluorescence signal is corrected according to the current temperature information, the implantation time of the sensor and the accumulated illumination time of the sensor, and a normalized fluorescence enhancement signal is output and transmitted to the signal receiver. The signal receiver can correspond the fluorescence signal to the content of the glucose in the blood through a neural network prediction algorithm and output the blood glucose value at that time. The signal receiver can share the blood sugar value of the user to family, friends and lovers in real time according to the setting of the user. Meanwhile, the signal receiver uploads the data to the cloud in real time, a database of the blood sugar changes of the user is established, and the database can be accessed by an information system of a hospital. Under the condition of permission of the patient, the main doctor can check the blood sugar value of the patient for a period of time to obtain the blood sugar change trend, the information can help the doctor to give a more accurate personalized treatment and maintenance scheme, and optional doctors can also add medical orders in the personal blood sugar information base of the patient. The doctor can also continuously observe the blood sugar change of the patient during the treatment period of the patient, and the treatment scheme can be modified more purposefully.

Alternatively, when the concentration of the phenylboronic acid derivative is changed, the range of the fluorescence detection of blood glucose may be changed. FIG. 7 is a graph showing the change of fluorescence intensity of phenylboronic acid derivatives with blood glucose concentration according to an embodiment of the present invention. Wherein the concentration of the phenylboronic acid derivative is 0.078mg/ml. As shown in FIG. 7, when the concentration of the phenylboronic acid derivative was 0.078mg/ml, the range of the blood glucose concentration that could be detected was 0 to 4.5mM.

FIG. 8 is a graph showing the variation of fluorescence peak intensity of phenylboronic acid derivatives with blood glucose concentration according to the present invention.

Wherein the concentration of the phenylboronic acid derivative is 0.39mg/ml. As shown in FIG. 8, when the concentration of the phenylboronic acid derivative was 0.39mg/ml, the range of the blood glucose concentration that could be detected was 0 to 15mM.

Fig. 9 is a flowchart of a detection process based on an optical waveguide sensor according to an embodiment of the present invention. The execution subject of the method in this embodiment may be a signal receiver. As shown in fig. 9, includes:

step 901, acquiring physiological index information sent by a wearable sensing chip, wherein the physiological index information is acquired at preset time intervals or continuously acquired based on an optical waveguide sensor in the sensing chip.

And 902, analyzing and processing the received physiological index information, and sending the processed information to a health monitoring platform so that the health monitoring platform displays the processed information.

Optionally, predicting the received physiological index information includes:

For the specific implementation principle and effect of the method in this embodiment, reference may be made to the foregoing embodiments, which are not described herein again.

Fig. 10 is a flow chart of another detection method based on an optical waveguide sensor according to an embodiment of the present invention. The execution subject of the method in this embodiment may be a health detection platform. As shown in fig. 10, includes:

1001, receiving information obtained by analyzing and processing physiological index information by a signal receiver, wherein the physiological index information is acquired at intervals of preset time or continuously acquired based on an optical waveguide sensor in a sensing chip;

and step 1002, displaying the information obtained after the analysis processing.

and displaying the processed information for the tested user and the associated user.

Optionally, the method further includes:

storing at least one of the following information of the tested user: personal basic information, change information of physiological index information, associated information with associated users, region information, age and work attributes; and/or the presence of a gas in the gas,

displaying at least part of information of the tested user to medical staff under the authorization of the tested user; and/or the presence of a gas in the atmosphere,

Optionally, the method further includes:

Fig. 11 is a schematic diagram of a detection principle of an optical waveguide sensor according to an embodiment of the present invention. As shown in fig. 11, the sensing chip is mainly for the optical waveguide sensor, and the sensor that assists other signal calibration units. The optical waveguide sensor transmits signal light to the optical sensing layer through the optical waveguide, and the optical sensing layer changes optical response after selectively capturing one or more physiological indexes. These optical responses are then transmitted to the photodetection module via optical waveguides. Through a signal calibration algorithm, accurate and continuous physiological index information is obtained, and finally, one or more pieces of physiological index information are output to a signal receiver through a signal transmitting circuit.

The physiological index information sent by the sensing chip in real time can be received by special independent signal receiving equipment or a mobile phone. The signal receiver can analyze and process the physiological index information, and finally, the data can be transmitted to the health detection platform for cloud storage.

The health detection platform comprises an information sharing platform, a health information base and a hospital-side information system.

The information sharing platform can set an information sharing mode and sharing permission. The manner in which information is shared may include selective partial sharing of information between family, friends, lovers and attending physicians. The setting of the sharing permission is specifically represented by that the user can set the sharing permission according to the requirement of the user. Optionally, the information sharing platform further has an early warning function, and the user may receive the early warning information at the signal receiver.

The health information base comprises personal basic information, changes of various physiological indexes of the user, health data and big data analysis heredity, eating habits and living habits factors between the related user and relatives and friends, and user information of the same region, the same working property and the same age group.

The user can set access authority in the information system at the hospital end, and the main doctor can access partial information of the health information base under the permission of the patient and has the authority to add medical advice in the health information base.

Fig. 12 is a schematic structural diagram of a detection apparatus based on an optical waveguide sensor according to an embodiment of the present invention. The detection device based on the optical waveguide sensor provided by the embodiment may include:

the acquisition module 1201 is configured to acquire physiological index information sent by a wearable sensing chip, where the physiological index information is acquired at preset time intervals or continuously acquired based on an optical waveguide sensor in the sensing chip.

The first display module 1202 is configured to analyze and process the received physiological indicator information, and send the processed information to a health monitoring platform, so that the health monitoring platform displays the processed information.

Optionally, when the first display module 1202 analyzes and processes the received physiological index information, it is specifically configured to:

and at least one of normalization, prediction and drawing of a change map is carried out on the received physiological index information.

Optionally, when the first display module 1202 predicts the received physiological index information, it is specifically configured to:

the physiological index information is predicted based on the neural network through the wearing position and the temperature information of the sensing chip and the physiological index information acquired through history.

The detection apparatus based on the optical waveguide sensor provided in this embodiment may implement the technical solution of the method embodiment shown in fig. 9, and the implementation principle and the technical effect are similar, which are not described herein again.

Fig. 13 is a schematic structural diagram of another detection apparatus based on an optical waveguide sensor according to an embodiment of the present invention. The detection device based on the optical waveguide sensor provided by the embodiment can comprise:

the receiving module 1301 is configured to receive information obtained by analyzing and processing the physiological index information by the signal receiver, where the physiological index information is acquired at preset time intervals or continuously acquired based on an optical waveguide sensor in the sensing chip.

A second displaying module 1302, configured to display the information obtained after the analysis.

Optionally, the second display module 1302 is specifically configured to:

Optionally, the receiving module 1301 is further configured to:

The detection apparatus based on the optical waveguide sensor provided in this embodiment may implement the technical solution of the method embodiment shown in fig. 10, and the implementation principle and technical effect are similar, which are not described herein again.

Fig. 14 is a schematic structural diagram of a signal receiving device according to an embodiment of the present invention. As shown in fig. 14, the signal receiving apparatus provided in this embodiment may include: at least one processor 1401 and memory 1402;

the memory 1402 stores computer-executable instructions;

the at least one processor 1401 executes the computer-executable instructions stored by the memory 1402, causing the at least one processor 1401 to perform a method for optical waveguide sensor-based detection as described in the embodiment illustrated in fig. 9.

Wherein the memory 1402 and the processor 1401 may be connected via a bus 1403.

For a specific implementation principle and effect of the signal receiving device provided in this embodiment, reference may be made to relevant descriptions and effects corresponding to the embodiments shown in fig. 1 to fig. 11, which are not described herein again.

Fig. 15 is a schematic structural diagram of a monitoring device according to an embodiment of the present invention. As shown in fig. 15, the monitoring device provided in this embodiment may include: at least one processor 1501 and memory 1502;

the memory 1502 stores computer-executable instructions;

the at least one processor 1501 executes computer-executable instructions stored by the memory 1502 to cause the at least one processor 1501 to perform the optical waveguide sensor-based detection method described in the embodiment illustrated in fig. 10.

The memory 1502 and the processor 1501 may be connected by a bus 1503.

For specific implementation principles and effects of the monitoring device provided in this embodiment, reference may be made to relevant description and effects corresponding to the embodiments shown in fig. 1 to fig. 11, which are not described in detail herein.

Embodiments of the present invention further provide a computer-readable storage medium, on which a computer program is stored, where the computer program is executed by a processor to implement the detection method based on the optical waveguide sensor provided in any embodiment of the present invention.

Embodiments of the present invention further provide a computer program product, which includes a computer program, and when the computer program is executed by a processor, the detection method based on an optical waveguide sensor according to any embodiment of the present invention is implemented.

In the embodiments provided in the present invention, it should be understood that the disclosed apparatus and method may be implemented in other ways. For example, the above-described apparatus embodiments are merely illustrative, and for example, a division of modules is merely a division of logical functions, and an actual implementation may have another division, for example, a plurality of modules or components may be combined or integrated into another system, or some features may be omitted, or not executed. In addition, the shown or discussed mutual coupling or direct coupling or communication connection may be an indirect coupling or communication connection through some interfaces, devices or modules, and may be in an electrical, mechanical or other form.

The modules described as separate parts may or may not be physically separate, and parts displayed as modules may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the modules may be selected according to actual needs to implement the solution of the present embodiment.

In addition, functional modules in the embodiments of the present invention may be integrated into one processing unit, or each module may exist alone physically, or two or more modules are integrated into one unit. The unit formed by the modules can be realized in a hardware mode, and can also be realized in a mode of hardware and a software functional unit.

The integrated module implemented in the form of a software functional module may be stored in a computer-readable storage medium. The software functional module is stored in a storage medium and includes several instructions for causing a computer device (which may be a personal computer, a server, or a network device) or a processor to execute some steps of the methods according to the embodiments of the present invention.

It should be understood that the Processor may be a Central Processing Unit (CPU), other general purpose Processor, a Digital Signal Processor (DSP), an Application Specific Integrated Circuit (ASIC), etc. A general purpose processor may be a microprocessor or the processor may be any conventional processor or the like. The steps of a method disclosed in connection with the present invention may be embodied directly in a hardware processor, or in a combination of hardware and software modules.

The memory may comprise a high speed RAM memory, and may further comprise a non-volatile storage NVM, such as at least one magnetic disk memory, and may also be a usb disk, a removable hard disk, a read-only memory, a magnetic or optical disk, or the like.

The bus may be an Industry Standard Architecture (ISA) bus, a Peripheral Component Interconnect (PCI) bus, an Extended ISA (Extended Industry Standard Architecture) bus, or the like. The bus may be divided into an address bus, a data bus, a control bus, etc. The buses in the figures of the present invention are not limited to only one bus or type of bus for ease of illustration.

The storage medium may be implemented by any type or combination of volatile and non-volatile memory devices, such as Static Random Access Memory (SRAM), electrically erasable programmable read-only memory (EEPROM), erasable programmable read-only memory (EPROM), programmable read-only memory (PROM), read-only memory (ROM), magnetic memory, flash memory, magnetic or optical disks. A storage media may be any available media that can be accessed by a general purpose or special purpose computer.

An exemplary storage medium is coupled to the processor such the processor can read information from, and write information to, the storage medium. Of course, the storage medium may also be integral to the processor. The processor and the storage medium may reside in an Application Specific Integrated Circuits (ASIC). Of course, the processor and the storage medium may reside as discrete components in an electronic device or host device.

Those of ordinary skill in the art will understand that: all or a portion of the steps of implementing the above-described method embodiments may be performed by hardware associated with program instructions. The foregoing program may be stored in a computer-readable storage medium. When executed, the program performs steps comprising the method embodiments described above; and the aforementioned storage medium includes: various media that can store program codes, such as ROM, RAM, magnetic or optical disks.

Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. This invention is intended to cover any variations, uses, or adaptations of the invention following, in general, the principles of the invention and including such departures from the present disclosure as come within known or customary practice within the art to which the invention pertains. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the invention being indicated by the following claims.

It will be understood that the invention is not limited to the precise arrangements that have been described above and shown in the drawings, and that various modifications and changes can be made without departing from the scope thereof. The scope of the invention is limited only by the appended claims.

Claims

1. A detection system based on an optical waveguide sensor, comprising: the system comprises a wearable sensing chip, a signal receiver and a health monitoring platform;

2. The system of claim 1, wherein the optical waveguide sensor comprises: the device comprises an excitation light source, a first lens, a first optical waveguide, an optical sensing module, a second optical waveguide, a second lens and a photoelectric detection device;

3. The system of claim 2, wherein the optical sensing module comprises: a wavelength division multiplexing module and at least one detection component;

each detection component comprises a third optical waveguide and an optical sensing layer, wherein the third optical waveguide is connected with the second end of the wavelength division multiplexing module and is used for transmitting the optical signal acquired from the second end to the detected part; the optical sensing layer is used for collecting an optical response signal obtained after the optical signal passes through the measured part, and transmitting the obtained optical response signal to the second optical waveguide through the third optical waveguide and the wavelength division multiplexing module.

4. The system of claim 3, wherein the optical waveguide sensor is configured to detect one or more physiological indicators; a corresponding detection component and a photoelectric detection device are arranged for each item of physiological index information.

5. The system according to any one of claims 1-3, wherein the physiological metric information includes at least one of: cholesterol, low density lipoprotein, uric acid, urea, creatinine, glucose, catecholamine, acetylcholine, theophylline, pH, lactic acid, sialic acid, active oxygen, sodium ion, potassium ion, glutamic-pyruvic transaminase, alkaline phosphatase, carcinoembryonic antigen, alpha-fetoprotein.

6. A system according to claim 2 or 3, wherein the optical response signal is indicative of at least one of: the light absorption is enhanced or weakened, the light scattering is enhanced or weakened, the fluorescence is enhanced or quenched, a Raman scattering peak is generated, and a surface plasmon resonance peak moves.

7. The system of claim 3, wherein the sensing chip further comprises: and the signal calibration unit is used for calibrating the physiological index information acquired by the optical waveguide sensor.

8. The system of claim 7, wherein the sensing chip further comprises at least one of: a temperature sensor, a humidity sensor, a timer and an ion concentration sensor;

correspondingly, the signal calibration unit is specifically configured to perform at least one of the following operations on the physiological index information acquired by the optical waveguide sensor:

9. The system of claim 7, wherein the calibration coefficients used to calibrate the physiological index information are calibration coefficients determined based on the material of the optical sensing layer.

10. The system of claim 7, wherein the sensing chip further comprises: and the signal transmitting circuit is used for transmitting the calibrated physiological index information to the signal receiver.

11. The system according to any one of claims 1-3, wherein the signal receiver is specifically configured to perform at least one of normalization, prediction, and mapping of the received physiological indicator information, and to send the processed information to the health monitoring platform.

12. The system of claim 11, wherein the signal receiver, when performing the predictive processing of the physiological indicator information, is specifically configured to:

13. The system of any one of claims 1-3, wherein the health monitoring platform comprises at least one of:

the health information base is used for storing at least one of the following information of the tested user: personal basic information, change information of physiological index information, associated information with associated users, region information, age and work attributes;

14. The system according to claim 13, wherein the information system applied to the hospital includes a device for printing personal health information provided in the hospital.

15. The system of claim 13, wherein the health monitoring platform is further configured to:

16. A detection method based on an optical waveguide sensor is characterized by being applied to a signal receiver, and the method comprises the following steps:

17. The method of claim 16, wherein analyzing the received physiological metric information comprises:

18. The method of claim 17, wherein predicting the received physiological metric information comprises:

19. The method according to any one of claims 16-18, wherein the physiological metric information comprises at least one of: cholesterol, low density lipoprotein, uric acid, urea, creatinine, glucose, catecholamine, acetylcholine, theophylline, pH, lactic acid, sialic acid, active oxygen, sodium ion, potassium ion, glutamic-pyruvic transaminase, alkaline phosphatase, carcinoembryonic antigen, and alpha-fetoprotein.

20. The method according to any one of claims 16 to 18, wherein the physiological indicator information is physiological indicator information obtained based on at least one of optical absorption detection, optical scattering detection, fluorescence detection, raman detection, surface plasmon resonance detection.

21. The method according to claim 16, wherein the received physiological index information is specifically information obtained by calibrating the physiological index information detected by the optical waveguide sensor through a signal calibration unit of the sensing chip.

22. A detection method based on an optical waveguide sensor is applied to a health monitoring platform, and comprises the following steps:

receiving information obtained by analyzing and processing physiological index information by a signal receiver, wherein the physiological index information is acquired at preset time intervals or continuously acquired based on an optical waveguide sensor in a sensing chip;

and displaying the information obtained after the analysis processing.

23. The method of claim 22, wherein presenting the information obtained after the analyzing comprises:

24. The method of claim 22, further comprising:

25. The method of any one of claims 22-24, further comprising:

26. A detection device based on an optical waveguide sensor, characterized in that the device comprises:

27. A detection device based on an optical waveguide sensor, the device comprising:

the receiving module is used for receiving information obtained after the signal receiver analyzes and processes the physiological index information, wherein the physiological index information is acquired at preset time intervals or continuously acquired on the basis of an optical waveguide sensor in the sensing chip;

28. A signal receiving apparatus, comprising: at least one processor and memory;

the memory stores computer execution instructions;

the at least one processor executing the computer-executable instructions stored by the memory causes the at least one processor to perform the optical waveguide sensor-based detection method of any one of claims 16-21.

29. A monitoring device, comprising: at least one processor and a memory;

the memory stores computer execution instructions;

execution of the computer-executable instructions stored by the memory by the at least one processor causes the at least one processor to perform the optical waveguide sensor-based detection method of any one of claims 22-25.

30. A computer-readable storage medium having computer-executable instructions stored thereon, which when executed by a processor, are configured to implement the method of any one of claims 16-25 for optical waveguide sensor-based detection.

31. A computer program product comprising a computer program, characterized in that the computer program, when being executed by a processor, implements the optical waveguide sensor based detection method according to any one of claims 16-25.