CN115397502A - Liquid injection device, system thereof and cartridge unit - Google Patents
Liquid injection device, system thereof and cartridge unit Download PDFInfo
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- CN115397502A CN115397502A CN202180028185.5A CN202180028185A CN115397502A CN 115397502 A CN115397502 A CN 115397502A CN 202180028185 A CN202180028185 A CN 202180028185A CN 115397502 A CN115397502 A CN 115397502A
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- liquid injection
- liquid
- cartridge unit
- unit
- injection apparatus
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Abstract
A liquid injection device (1) for injecting a liquid into the skin by a microneedle (10) is composed of a cartridge unit (20) having the microneedle, a discharge hole (11) for discharging the liquid, an injector section (21) for containing the liquid, and a gasket section (23) for pushing out the liquid from the injector section toward the discharge hole, and a main body (30) having at least a cartridge mounting section for detachably mounting the cartridge unit and sliding sections (37, 38) for moving the gasket section of the mounted cartridge unit in the axial direction, and the cartridge unit can be replaced and used.
Description
Technical Field
The present invention relates to a liquid injection device for injecting a liquid such as a cosmetic water or a drug solution into the skin through microneedles, a system thereof, and a cartridge unit.
Background
Microneedles are used as percutaneous absorption devices in the medical and cosmetic fields.
The skin is composed of epidermis and dermis. The epidermis is a hard protein composed of the stratum corneum, the basal layer, the stratum spinosum, and the like. The stratum corneum forms a barrier that prevents bacteria and dust from entering, and prevents moisture from evaporating from the body; the basal layer produces keratinocytes and melanin protects the skin from uv light.
Meanwhile, the dermis is composed of fibrous collagen, gel-like hyaluronic acid, etc., and is a highly elastic protein layer that spreads over nerves, blood vessels, lymph vessels, etc.
The amount of liquid that can be injected into the skin is extremely small compared to the amount that enters the subcutaneous tissue, and is 0.2 ml or less in the highly elastic dermis and about 1/100 of the amount in the epidermis that is a scleroprotein. In addition, since the thickness of the skin is about 1.5 to 2mm in total of the epidermis and dermis, the microneedles are effective devices that can control the transdermal absorption amount and depth.
Especially in the cosmetic field, the aim is to infuse cosmetic liquids into the epidermis, which has low permeability. For this purpose, a closed type microneedle is used in the cosmetic field, in which collagen or hyaluronic acid hardened in a needle shape is spread in a needle-like shape, and fixed to a skin-repairing part such as eyes or a facial line with an adhesive for a long time to allow penetration.
As related prior art, patent document 1 discloses a structure including a housing, a microneedle array holder holding a microneedle array, and a Shuttle (Shuttle) holding a cartridge, wherein the microneedle array holder is movable between a retracted position and an extended position. In this structure, only the cartridge containing the liquid medicine can be replaced, and the microneedle array and its microneedle array holder, which are disposed separately from the cartridge, are moved from the retracted position to the extended position by the energy storage device. The energy storage means is in particular a helical spring, which contacts the skin at a certain impact speed.
Further, patent document 2 discloses a manipulation tool which can easily and reliably inject a desired amount of fluid into skin tissue in a short time when intradermal injection is performed by a fluid injector using a multi-microneedle device. The instrument is characterized by being simple and low-cost, and has a mechanism for moving the needle in the device body in sequence between an initial position in which the needle is retracted into the opening, a first position in which the needle projects from the opening to the outside by a first distance, and a second position in which the needle projects to the outside by a second distance shorter than the first distance. After the fluid exits at the second location, the injector is pushed to the initial position by magnetic force.
Since the predetermined amount cannot be repeatedly injected since it returns to the initial position every time, a structure is disclosed as a structure for injecting the entire fluid of the desired amount in the fluid injector into the skin tissue of the desired position.
Patent document 3 discloses a medicament delivery assembly having a delivery assembly including a plurality of microneedles configured to deliver a drug transdermally to a patient and including a sensing unit configured to measure at least one physical parameter determined according to the volume of a medicament within the device. The device discloses a structure that forms a capacitor with two electrodes between which the drug flows and the volume is measured by measuring the capacitance of the capacitor. In addition, a structure for performing measurement by the photodetector is also disclosed. In this case, these measuring devices are required between the microneedles and the housing portion for the drug, and there is a problem that the structure and control of the device become complicated, in addition to the inability to easily replace the housing portion and the microneedles.
Documents of the prior art
Patent document
Patent document 1: JP 2016-523115A
Patent document 2: international publication No. 2014/017561
Patent document 3: japanese patent publication No. 2020-504650.
Disclosure of Invention
Technical problem to be solved by the invention
As a problem with the above-described prior art, the adhesive may cause rash, swelling, and the like, due to the sealed-type microneedles being in contact with the skin for a long time. In addition, many sealing members are required to permeate the cosmetic liquid over a large area, which is inefficient.
On the other hand, when the microneedle is attached to the tip of the syringe and injected from the needle, most of the liquid may leak out without entering the skin due to low skin permeation amount. In particular, when a liquid is injected into the epidermis, the injection amount needs to be controlled in units of several μ l, and the operation itself is difficult because of a small amount. In addition, the injected cosmetic liquid is expensive, and if it overflows from the skin, the cost performance is much worse.
The present invention has been made in view of the problems of the prior art, and provides a liquid injection device for injecting a liquid from a microneedle into skin having low permeability, which provides a technique for accurately and easily injecting a trace amount of liquid. Meanwhile, it is an object to provide a technology that can inject a liquid into the epidermis in a short time without waste and can inject a cosmetic liquid in a large area by cooperating with the operation of a user when the skin is in contact with the device.
Means for solving the problems
In order to solve the above problems, the present invention provides the following liquid injection device.
According to a first aspect of the present invention, there is provided a liquid injection device for injecting a liquid into skin by microneedles, comprising a cartridge unit and a main body, wherein the cartridge unit comprises the microneedles, a discharge hole for discharging the liquid, and a container portion for containing the liquid. The main body further includes a cartridge mounting portion for detachably mounting the cartridge unit, and a biasing force generating mechanism for generating a discharging action of the liquid with respect to the mounted cartridge unit. Thus, a liquid injection device that can be used with a replaceable cartridge unit can be provided.
According to a second aspect of the present invention, in the cartridge unit, the distal end portion includes microneedles and a discharge hole, and the distal end portion can be attached to the container portion for use.
According to a third aspect of the present invention, the liquid injection device may further include a discharge amount setting device for setting a discharge amount of the liquid when the liquid is discharged from the cartridge unit.
According to a fourth aspect of the present invention, the discharge amount setting means may be configured to set the discharge amount per unit time by changing the state of the discharge hole according to the characteristics of the liquid.
According to a fifth aspect of the present invention, the container portion of the cartridge unit may include at least a syringe portion and a gasket portion for extruding the liquid from the syringe portion to the discharge hole, and the urging force generating mechanism may include a sliding portion for axially moving the gasket portion of the mounted cartridge unit.
According to a sixth aspect of the present invention, the liquid injector may further include a discharge frequency setting device for setting a frequency of discharging the liquid from the cartridge unit.
According to a seventh aspect of the present invention, the liquid injection device may further include a driving device for axially driving the sliding portion of the liquid injection device.
According to an eighth aspect of the present invention, the discharge amount setting device may include a first control unit that sets the discharge amount per unit time by controlling a driving speed of the driving device.
According to a ninth aspect of the present invention, the discharge amount setting device may include a second control unit that adjusts the amount of extrusion according to the bead portion of the driving device.
According to a tenth aspect of the present invention, the driving device may be a motor including a driving shaft for driving the sliding portion in the axial direction.
According to an eleventh aspect of the present invention, the liquid injection apparatus may further include an operation unit for manually operating the slide unit.
According to a twelfth aspect of the present invention, there is provided the liquid injection apparatus, wherein the urging force generating mechanism includes a vibrating portion that vibrates the cartridge unit in the axial direction.
According to a thirteenth aspect of the present invention, the present invention may further include a third control unit that sets a vibration frequency of the vibration unit in the acting force generating mechanism.
According to a fourteenth aspect of the present invention, the liquid injection device may further include a fourth control unit that controls the force applied from the biasing mechanism to the cartridge unit.
According to a fifteenth aspect of the present invention, there is provided a liquid injection device, wherein the main body of the liquid injection device comprises a grip portion to be gripped by a user and an action portion including at least a cartridge mounting portion, and an angle between the grip portion and the action portion in a longitudinal direction is 50 degrees to 80 degrees.
According to a sixteenth aspect of the present invention, in the liquid injection apparatus, a fifth control unit may be provided which detects the tilt angle of the main body and controls to be activatable or to notify the user when the tilt angle is within a predetermined angle range.
According to a seventeenth aspect of the present invention, the fifth control unit may set the discharge amount per unit time based on the detected inclination angle of the main body.
According to an eighteenth aspect of the present invention, there may be provided: a skin sensor for detecting the proximity or contact of the vicinity of the microneedle with the skin, and a sixth control unit for controlling the urging force generating mechanism based on the detection result.
According to a nineteenth aspect of the present invention, in the configuration in which the urging force generating mechanism includes the vibrating portion, the cartridge unit may include a plurality of discharge holes, and the discharge holes may be arranged at intervals ranging from 2mm to 20 mm.
According to a twentieth aspect of the present invention, there is provided a system using the liquid injection device described above, the system including a plurality of cartridge units each containing two or more liquids having different efficacies and a main body, the system being capable of providing a plurality of efficacies by replacing the cartridge units and using the cartridge units.
According to a twenty-first aspect of the present invention, there is provided a system comprising a plurality of cartridge units each having at least one microneedle having a different length, arrangement density and distribution area, and a main body, wherein the system can provide various effects by replacing the cartridge units and using the cartridge units.
According to a twenty-second aspect of the present invention, there is provided a system in which the distal end portion includes microneedles and discharge holes, and in a configuration in which the distal end portion is attached to the container portion and used, the distal end portion is replaced with a replacement cartridge unit, thereby providing various effects.
Effects of the invention
The invention achieves the following effects through the structure.
By providing the cartridge unit with the microneedles and the injector section for containing the cosmetic liquid, the drug solution, etc., it is possible to select and provide the microneedles in the optimum state for the liquid, and the user can perform various required operations without bothering for advanced knowledge or selection when replacing the cartridge unit.
The liquid injection device of the invention has the components of a cartridge unit and a sliding part driven by a motor and the like, and has the advantages of small number of components, simple structure, high cost performance and stable quality.
In addition, in the configuration having the distal end portion, since the microneedle and the syringe section can be provided separately, the cartridge unit that can be adapted to the liquid injection device of the present invention can be easily provided even if the authentication system or the like differs. Further, the syringe section as a general-purpose component contributes to mass production.
In the structure having the motor of the present invention, the discharge of the liquid can be controlled. That is, the discharge speed of the liquid may be adjusted by the discharge speed adjusting means, or the extrusion amount of the bead portion may be adjusted by using the origin sensor.
Further, by controlling the motor by providing a skin sensor that detects contact with the skin in the vicinity of the microneedles, it is possible to discharge the liquid at an appropriate time according to the distance from the skin.
By providing the elastic support member for elastically supporting the predetermined portion of the syringe unit toward the gasket portion side, the cartridge unit can be supported with appropriate elasticity and pressure, and the waterproof function on the main body side can be facilitated.
In the structure having the vibrating portion of the present invention, the liquid can be easily discharged. In particular, by controlling the vibration frequency and intensity, the discharge amount can be adjusted to an appropriate level.
Further, by controlling the motor by providing a skin sensor that detects contact with the skin or the like near the microneedles, it is possible to discharge the liquid at an appropriate time according to the distance from the skin.
By providing the elastic support member for elastically supporting the predetermined portion of the syringe unit toward the gasket unit side, the cartridge unit can be supported with appropriate elasticity and pressure, and waterproofing of the main body side can be facilitated.
The present invention provides the cartridge unit and the front end portion thereof as a replaceable system, and can freely select various types of liquid and microneedle combinations, contributing to providing various effects.
Drawings
Fig. 1 is a sectional view for explaining an internal mechanism of a liquid injection device according to a first embodiment of the present invention.
Fig. 2 is an oblique view thereof.
Fig. 3 is an enlarged head view.
Fig. 4 is a view showing a state where the cartridge unit is assembled.
Fig. 5 is a view showing a state in which the cartridge unit is detached.
Fig. 6 is an explanatory diagram of a control circuit according to the first embodiment of the present invention.
Fig. 7 is an explanatory diagram showing an implementation state of the counter unit of the linear motor.
Fig. 8 is a view showing an appearance of a liquid injection device according to a first embodiment of the present invention.
Fig. 9 is an oblique view of a liquid injection device according to a second embodiment of the present invention.
Fig. 10 is a sectional view illustrating an internal mechanism thereof.
Fig. 11 is an explanatory diagram of the vibration mechanism.
Fig. 12 is a perspective view of the tip portion.
Fig. 13 is an explanatory view showing the shape of the microneedle.
Fig. 14 is a diagram showing another state of the tip end portion.
Fig. 15 is an explanatory diagram of a control circuit according to the second embodiment of the invention.
Fig. 16 is an explanatory diagram showing a swing state of the head.
Fig. 17 is a view showing an angle of the grip portion and the action portion.
Detailed Description
Hereinafter, embodiments of the present invention will be described based on examples shown in the drawings. Further, the embodiments are not limited to the following.
(first embodiment)
Fig. 1 is a sectional view for explaining an internal mechanism of a liquid injection device according to a first embodiment of the present invention, and fig. 2 is an oblique view thereof in a state where a circuit board is removed.
The present invention is a liquid injection device 1 for injecting a liquid into the skin through microneedles 10, which is composed of a cartridge unit 20 and a main body 30.
The microneedle 10 having the discharge hole 11 is disposed at the tip end, and includes a syringe section 21 for containing a liquid and a gasket section 22 for pushing the liquid from the syringe section 21 to the discharge hole 11 at the rear side, and these constitute a cartridge unit 20.
In the present invention, the cartridge unit is particularly characterized in that the cartridge mounting portion is disposed on the main body of the liquid injection device, and the cartridge unit can be detachably mounted. Further, the urging force generating mechanism according to the present invention includes a sliding portion for moving the gasket portion of the cartridge unit in the axial direction, so that the liquid in the cartridge is discharged from the discharge hole.
The sliding portion may be manually slid or automatically slid. For example, in the case of manual operation, it may be configured that an operation portion such as a slide bar or a push button is provided on the main body, and the liquid is discharged from the discharge hole by an axial movement of the gasket portion following the movement of the operation portion.
In the present embodiment, a structure in which the slide portion is operated by the driving device is disclosed. As the driving device, a known driving device that operates in the axial direction, such as a hydraulic cylinder or an air cylinder, may be used in addition to a linear motor or the like described later. These driving means may be controlled by the control means described below.
The main body 30 is configured by a head portion 31 covering the periphery of the microneedle 10 at the tip end, a housing portion 32 housing the cartridge unit 20 and other internal components, a linear motor 33 driving a drive shaft in the housing portion 32, a battery 34 supplying electric power, a control board 35 having a control circuit, an operation switch 36 for operation, and the like.
In use, with the head portion 31 removed, the cartridge unit 20 is inserted into the cylindrical cartridge mounting portion 320 at the front end of the housing portion 32, and the head portion 31 is fitted into the head receiving portion 321 at the front end of the housing portion 32.
Fig. 3 shows a state of the inside of the head 31. As shown in fig. 2, two cams 3210 are provided on the outer peripheral surface of the head receiving portion 321, and the cam groove 311 that engages with the cams 3210 is provided on the inner peripheral surface of the head 31, so that the head 31 can be easily attached and detached by being pressed against the head receiving portion 321 and rotated.
At this time, the cartridge unit 20 is stably supported by the elastic support member provided inside the head portion 31, i.e., the cartridge pressing rubber 310 made of rubber and elastically supported toward the washer portion 22 in the present embodiment.
The cartridge pressing rubber 310 suppresses shaking of the cartridge unit 20, and also has a waterproof effect of preventing liquid and the like from entering the inside from the periphery of the cartridge unit.
Fig. 4 is a view showing an assembled state of the cartridge unit 20, and fig. 5 is a view showing a separated state of the cartridge unit.
In the present embodiment, the cartridge unit 20 is configured by a distal end portion 23 including the microneedles 10 and the discharge holes 11, a cylindrical syringe portion 21 for containing a liquid, and a gasket portion 22. The liquid in the syringe section 21 is discharged from the discharge hole 11 through a not-shown flow hole in the distal end portion 23.
More specifically, the gasket portion 22 is composed of a seal member 220 that seals the liquid in the syringe portion 21, and a back end member 221 that receives the driving force from the linear motor 33.
The back-end unit 221 may be configured such that the manual operation unit pushes and slides the back-end unit 221, as in the case of other driving devices.
It is well known that a microneedle having a tip portion 23 with a large number of very fine needles having a diameter and length of less than 1mm can penetrate through the stratum corneum layer of an impermeable substance and penetrate a drug more shallowly than the dermis layer having many pain spots. The injection device can be used for medical applications such as injection of drugs such as insulin and vaccines, and can also be used for cosmetic applications such as injection of cosmetic liquids.
As the material of the microneedles, collagen, hyaluronic acid, etc. are preferably used in addition to PLA (polylactic acid). For cosmetic use, a solid needle is generally used, and cosmetic liquid is discharged from the discharge hole 11 in the flat portion around the needle, and can permeate through the skin pores opened by the microneedle.
In the present invention, the discharge amount setting means is provided for setting the discharge amount when discharging the liquid from the cartridge unit 20. As the discharge amount setting means, the discharge amount per unit time can be set by changing the frictional resistance of the fluid by adjusting the diameter of the discharge hole, the length of the passage portion, and the state of the discharge hole such as the material. According to this configuration, even if the driving device is manually operated, if the driving device is operated with a certain strength, it is possible to maintain an appropriate discharge amount suitable for the liquid to be used.
By thus changing the states of the microneedles and the discharge holes suitable for the cartridge unit 20, the size of the discharge holes can be changed and adjusted according to the amount, momentum, viscosity, etc. of the liquid. If the force is too large or the amount is too large, the liquid may drip or not be properly applied, resulting in a large loss of the cosmetic liquid, and therefore it is important to appropriately adjust the discharge speed.
In addition, without changing the state of the discharge hole, a not-shown pressurizing chamber may be provided in the cartridge unit 20, and the discharge amount may be set by adjusting the speed of the liquid flowing out from the pressurizing chamber to the discharge hole.
In the present embodiment, the liquid in the syringe section 21 is pushed out by the linear motor 33, but even in this case, the discharge amount can be set by changing the hole diameter of the discharge hole 11.
The state of the discharge port 11 is preferably selected depending on the liquid inside, and for example, when the viscosity of the liquid is 30 Pa.S, the pore diameter is preferably about 0.2 to 1mm, and when the viscosity is 30000 Pa.S, the pore diameter is preferably 1mm to 2mm. In this way, depending on the viscosity of the liquid, varying the discharge orifice may allow for more effective application and help prevent clogging.
The diameter of the circular portion of the microneedle 10 is 5 to 25mm, for example, preferably about 12mm. This structure of pushing out the liquid by the gasket portion 22 can be applied to a cosmetic liquid having a high viscosity, for example, 5000Pa · S or more, and the pore diameter of the discharge hole can be selected from a wide range of 30 μm to 2mm.
In the structure including the plurality of discharge holes 11, the discharge holes for liquid are preferably arranged at intervals of at least 100 μm to 500 μm. By ensuring such a distance, the microneedles and the discharge holes can be alternately and efficiently arranged in a dispersed manner.
The present invention is not limited to solid microneedles, and hollow needles may also be used. In this case, the discharge hole 11 is configured to be discharged from the hole of the microneedle. In particular, in medical applications, it is common to use hollow microneedles, but solid microneedles for cosmetic applications are not excluded.
One end of the injector portion 21 may be screwed with the front end portion 23 or a cap, not shown, and the other end may be sealed with a gasket portion 22 to provide the cartridge unit 20 for various liquids. The syringe portion 21 may be made of a transparent member so that the amount of liquid inside can be easily confirmed.
Since the microneedles 10 act on the human body, manufacturers may be restricted by licensing regulations and laws and regulations, but such separability of the leading end portions 23 facilitates application of the licensed microneedles 10 to the cartridge unit 20 of the present invention.
In the practice of the present invention, the microneedles 10 and the syringe unit 21 of the cartridge unit 20 may be formed integrally.
As the liquid contained in the syringe part 21, a cosmetic liquid such as collagen, hyaluronic acid, placental original solution, hydroquinone, tranexamic acid, vitamin derivative, or the like can be used. In addition, as the hair growth promoting liquid, minoxidil, finasteride, swertia extract, vitamin derivatives, and the like can be used.
In the present invention, the application of the liquid to be treated is not limited to the cosmetic application, the medical application, and the like, and thus, the liquid having various effects can be freely used by replacing the cartridge unit 20, which is advantageous.
It is also preferable to have a structure as described below: the washer portion 22 of the cartridge unit 20 can move only forward and cannot return backward. If the gasket portion 22 returns, foreign matter may be mixed into the internal liquid or an optimal combination with the microneedles may be broken, and therefore, the gasket portion 22 may have, for example, a ratchet-like and irreversible action.
The rear end of the washer 22 abuts a plunger 37 that slides back and forth in the housing 32, and the plunger 37 is connected to a drive shaft 38 to form a sliding portion.
In the present invention, when the driving means, in particular, the linear motor 33 is used, the following control can be performed. That is, the linear motor 33 slides forward by a predetermined amount of movement under the control of the control circuit 40 provided on the control board 35, and controls the squeezing out of the washer 23 of the cartridge unit 20, thereby achieving optimum liquid discharge.
Fig. 6 is an explanatory diagram of the control circuit 40. In the present embodiment, the control board 35 having an IC with a motor driver and the like is connected to the linear motor 33 and the operation switch 36, and further includes an origin sensor 44 and a skin sensor 45.
In the present invention, the following control is preferably performed on the linear motor 33.
First, the control circuit 40 includes a discharge speed adjustment unit 41 as a first control unit.
In the liquid injection device, when the optimum discharge amount per unit time is determined by the viscosity and the characteristics of the liquid, the discharge speed adjustment unit 41 may adjust the discharge speed by adjusting only the operation speed of the linear motor 33.
According to the discharge speed adjusting portion 41, the speed is reduced or the amount of movement is increased by the application portion and the liquid, and the liquid can be prevented from dripping, so that the necessary and sufficient application can be performed.
Next, the control circuit 40 includes an extrusion amount control unit 42 as a second control unit. By controlling the amount of extrusion of the plunger 37, the amount of liquid discharge can be accurately adjusted. If the plunger 37 moves only by an amount not dropping the liquid from the skin, corresponding to a distance of several microliters, an appropriate amount of the liquid is discharged from the discharge hole 11 of the cartridge unit 20.
In order to more accurately detect the amount of movement of the drive shaft 38, an origin sensor 44 may be provided. The origin sensor 44 is composed of, for example, a sensor stopper 440 and a sensor 441 attached to the case 32, and detects the origin position of the drive shaft 38. Then, as shown in fig. 7, a C-shaped light shielding plate 380 is provided at the connecting position of the drive shaft 38 and the plunger 37, and the number of times the light shielding plate 380 is shielded by the counter portion 46 is counted, whereby the extrusion amount based on the number of revolutions can be detected.
The cartridge unit 20 receives a sliding resistance from the washer 22 during operation, and the head 31 matches the amount of movement of the drive shaft 38 and the amount of movement of the washer 22 by the engagement of the cam 3210 with the cam groove 311 and a sufficient strength against the sliding resistance of the cartridge pressing rubber 310.
The number of revolutions of the counter part 46 is stored even if the power is turned off, and therefore, the extrusion amount control part 42 can continuously control the extrusion amount since the number of revolutions is added to the stored number of revolutions at the time of the next use.
The method of controlling the extrusion amount is not limited to the above-described configuration, and the position of the bead portion 22 may be detected by a known position sensor and controlled based on the detected position.
The liquid injection device of the present invention is not a general disposable type, but can reuse the liquid of the cartridge unit 20 several tens of times, and therefore, it is important to detect the origin position of the plunger 37 at the start of use and the position after use by the position sensor 44. As a result, the extrusion amount of the predetermined amount from the current position can be controlled again at the next start of use.
Further, the end of use of the cartridge unit 20 may be detected using the counter section 46. When the liquid inside becomes empty, even if the linear motor 33 is operated, the washer section 22 hits the front end surface of the syringe section 22 and cannot further operate, so the detected number of rotations of the counter section 46 becomes 0, and the error detection 47 is performed. In the case of an error detection 47, it is detected that the injector part 22 is empty.
If the syringe component 22 becomes empty, it is replaced with a new one.
Upon a false detection 47, the linear motor 33 is rotated, causing the plunger 37 to retract to the home position and stop, and the user may be prompted to change the cartridge.
If a position sensor is provided, the remaining amount of liquid can be detected from the current position of the gasket portion 22 without such erroneous detection.
As shown in the drawings, the linear motor includes a type in which a driving shaft protrudes from one side and a type in which a driving shaft protrudes from a rear side to extend a stroke. In the latter case, the light blocking plate 380 may be disposed at the rear end position of the drive shaft, instead of the connecting position between the drive shaft 38 and the plunger 37 as described above. Furthermore, the drive shaft itself may be detected by a sensor.
In the present invention, the cartridge unit may further include a discharge number setting device for setting the number of times the liquid is discharged from the cartridge unit. Conventionally, microneedle discharge has been generally performed only once, and when it is injected into the epidermis, the permeation rate of the epidermis is low, and it is possible to perform percutaneous absorption of the amount injected twice and the amount applied to the skin more efficiently.
Therefore, the control circuit 40 may further include the discharge control unit 43 to perform a plurality of discharges. In this case, the linear motor 33 may perform the drive control only a predetermined number of times.
In this configuration, the discharge control unit 43 can also control the discharge time. The discharge time may be arbitrarily discharged by a user's switch operation, or the skin sensor 45 may be provided to perform discharge based on input information thereof.
A skin sensor 45 is provided on the head 31. As shown in fig. 3, a terminal 312 of a skin sensor for detecting proximity or contact with the skin is provided, and the terminal 312 flows through the circuit board 36 by a minute current when it is contacted by the connecting shaft 39 provided on the upper surface of the housing 32, and proximity or contact with the skin can be detected by a well-known electrostatic sensor.
By activating the linear motor 33 in response to skin contact or the like, the liquid is continuously discharged from the discharge hole 11 every time the user contacts the skin with the injection device, and injection into the skin over a large area can be completed in a short time.
At this time, the time when the skin sensor 45 is separated from the skin is detected, and by controlling the discharge of the liquid using this as a trigger, the discharged liquid stays in the head 31 due to the surface tension between the microneedle, and when the microneedle is brought into contact with the skin again, the amount absorbed by the skin is the sum of the amount injected from the needle and the amount left in the head, and therefore, more liquid can be absorbed transdermally. The present structure is particularly useful when solid microneedles are used.
The above-described structure controls the number of ejections, but the number of injections of microneedles other than the number of ejections may also be changed. In the present embodiment, the microneedle is injected by pressing the body against the skin, but the microneedle may be connected to a vibration motor and injected by the vibration of the vibration motor a predetermined number of times. In this case, the control may be performed in combination with the discharge by the discharge control unit 43.
Fig. 8 shows the appearance of the liquid injection device 1 according to the first embodiment of the present invention. The user can hold the stick-shaped housing 2 and perform operations such as turning on/off of the power supply, mode selection, and discharge by operating the switch 36 and the like.
The housing 2 has a diameter of 3 cm to 5 cm, an overall length of 20 cm to 30 cm, a thickness and a length suitable for grasping with the palm of the user's hand, and can stably support the main body 30.
As described above, by removing the head 31, the cartridge unit 20 can be easily attached and detached. By the combination of the body and the plurality of cartridges, a system is achieved that can be used to provide multiple efficacy by replacing the cartridge unit.
By making the plurality of cartridge units different in at least one of the length, arrangement density, distribution area of the microneedles 10, for example, according to differences in parts such as the face and scalp, types of liquids, and differences between cosmetic and medical uses, various effects can be achieved.
In the case of the configuration having the distal end portion 23, the distal end portion 23 may be replaced with a replacement cartridge unit and used, thereby providing various effects.
Furthermore, the present invention may also provide only the cartridge unit 20 as a single body.
(second embodiment)
Next, a second embodiment having a different force generation mechanism will be shown. In this embodiment, the shape of the body is also different from that of the first embodiment, and the operation and effect thereof will be described.
Fig. 9 is an oblique view of a liquid injection device according to a second embodiment of the present invention, and fig. 10 is a sectional view for explaining an internal mechanism thereof.
The liquid injection apparatus 100 of the present embodiment is composed of a cartridge unit 120 and a main body 130. The cartridge unit 120 in the present embodiment does not have an injector portion or a gasket portion, but has a container portion 121 and a needle cap 122 screwed into the container portion as a leading end portion, and a protective cap that protects the microneedles 10 when not in use.
The needle cap 122 has many microneedles 10 and three discharge holes 124 (shown in fig. 12).
In the present embodiment, by applying vibration to the cartridge unit 120, the liquid in the container portion 121 is discharged from the discharge hole, and permeates the skin through the microneedle 10.
The main body 130 includes a grip portion 140 gripped by a user and an operating portion 150 having an attachment portion 151 of the cartridge unit 120 therein, and as shown in the drawing, the grip portion 140 and the operating portion 150 are each formed in a curved shape having an angle of 55 degrees in the longitudinal direction.
The case 141 of the grip portion 140 is integrally formed with the case 152 of the action portion, and in the present embodiment, the vibration portion is accommodated in the case 152 of the action portion as in the attachment portion 151. The vibrating portion is composed of a solenoid 160, a joint 161 connected to a shaft of the solenoid 160, a slider 162 vibrating forward and backward through the joint 161, and an outer cylinder holding the vibrating slider 162 on the outer periphery.
The solenoid 160 is fixed to the housing 152 by the elastic members 164 and 165, so that the vibration of the solenoid 160 is not directly transmitted to the housing 152. This improves the feeling of use and reduces noise.
In the present embodiment, the urging force generating mechanism includes a vibrating portion that vibrates the cartridge unit 120 in the axial direction, i.e., in the same direction as the direction in which the microneedles protrude. Fig. 11 illustrates this structure in detail. As shown in fig. 11 (a), the solenoid 160 includes a spring 1602 on the outer periphery of an electromagnet 1601, and vibrates in the axial direction by the action of the spring and the switch of the electromagnet. The vibration is transmitted to the slider 162 through the joint 161 connected to the shaft 1603 of the solenoid 160.
The slider 162 is provided with a plurality of slits 1621 in the axial direction and is elastic in the radial direction, and as shown in fig. 11 (B), an engaging convex portion 1622 is provided on the inner periphery thereof and engages with an engaging concave portion 1211 on the outer periphery of the container portion 121.
Therefore, when the cartridge unit 120 is inserted into the mounting portion 151 formed in the slider 162, it can be detachably mounted by the engagement of the engaging convex portion 1622 and the engaging concave portion 1211.
The curved portions of the grip portion 140 and the action portion 150 have operation switches 131 for operation. In addition, a battery 142 for supplying power and a control board 143 having a control circuit are housed in the case 141 of the grip portion 140.
The components respectively accommodated in the grip portion 140 and the acting portion 150 are preferable because of the good weight balance of the structure of the present embodiment, but the present invention is not limited thereto.
By controlling and vibrating the solenoid 160 as described above, the needle cap 122 is directed downward, and the cosmetic liquid or the like is discharged from the discharge hole 124 by the weight of the liquid in the container portion 121.
At this time, as the cosmetic liquid permeates to the skin surface by vibration, a tapping effect of tapping the skin gently can be obtained.
However, in order to achieve smooth discharge and optimum application amount, it is necessary to adjust the viscosity of the liquid, the hole diameter of the discharge hole, the vibration frequency, the stroke, and the like. Accordingly, the structure of the needle cap 122 and the control method of the solenoid 160 will be described in detail below.
Fig. 12 shows an oblique view of the needle cap 122 as the tip portion, and fig. 13 shows the shape of the microneedle.
As shown, the needle cap 122 has a rounded front end abutting the skin surface and has the discharge holes 124 at three points on the circumference while a large number of microneedles 10 are uniformly implanted in the circle.
The diameter of the circular portion is around 12mm, suitably in the range of 5 to 25mm. The pore diameter of the drain hole is preferably in the range of 0.8mm to 1.6mm at a preferred viscosity (200-1000 mPas) of the cosmetic liquid. Although one discharge hole may be provided at the center, by providing a plurality of discharge holes, the cosmetic liquid can be appropriately distributed to the microneedles 10 within the circle.
In the present embodiment using the vibrating portion as the urging force generating mechanism, the hole diameter of the discharge hole needs to be made relatively large as compared with the first embodiment. For this purpose, large-diameter discharge holes are arranged at appropriate intervals, and the centers of the discharge holes are arranged at the respective vertex positions of a virtual regular triangle having a side length of 6.6 mm. When the hole diameter of the discharge holes is within the above range, the spacing distance is preferably 4mm to 12mm.
In the present invention, another preferable state of the tip end portion is shown in fig. 14. In addition to fig. 14 (a) having the discharge holes 124 at three points in the above-described embodiment, (b) of fig. 14 has the discharge holes 124' at the vertex positions of the virtual square of the rounded tip, and a large number of microneedles 10 are implanted therearound.
In fig. 14 (c), the discharge holes 124' are provided at two opposing points on the circumference of the circular tip.
Further, (d) of fig. 14 has a discharge hole 124' at one point on the circumference of the circular leading end.
In addition, (e) of fig. 14 has one discharge hole 124' at the center position of the circular front end.
In the present invention, the diameter of the circular portion is preferably in the range of about 5mm to 25mm, and particularly, in the case of a large diameter close to 25mm, as shown in fig. 14 (b), discharge holes of four or more points are suitable, and on the other hand, in the case of a small diameter close to 5mm, as shown in fig. 14 (d) and (e), one point is sufficient.
In this embodiment, it is preferable that the discharge holes of the tip portion are arranged at intervals in the range of 2mm to 20 mm. That is, these are determined according to the size of the tip portion, and for example, when the diameter of the tip portion is 5mm and 4 dots are arranged as shown in fig. 14 (b), the interval is about 2mm. When the diameter is 25mm, the interval is about 20mm when two dots are arranged as shown in fig. 14 (c).
According to the findings of the inventors, it was confirmed that in the above numerical range, when the proper amount of liquid was discharged from the discharge hole by vibration, the liquid did not immediately leak even when the needle cap (122) was faced downward without vibration, and the effect of use was particularly excellent.
The microneedles in this example are substantially quadrangular pyramid-shaped having a flat surface portion on the upper surface, and as shown in fig. 13, the height (H) is about 200 μm, the bottom surface side length (L1) is about 100 μm, and the top surface side length (L2) is about 40 μm. Compared with the common micro-needle with a sharp front end, the flat top surface can ensure that the penetration effect of the cosmetic liquid is good and the feeling of pain is difficult. In terms of the effect of penetration and the strength of the microneedles, the ratio of L1: L2: H is preferably about 1.
In the first embodiment, various structures are disclosed for adjusting the discharge amount when discharging the liquid from the cartridge unit 20 by the discharge amount setting means. The present embodiment may be provided with the same discharge amount setting device.
Meanwhile, in the present embodiment including the vibrating portion, the following control is particularly preferably performed.
Fig. 15 is an explanatory diagram of the control circuit 400. In the present embodiment, the control board 143 provided with an IC or the like has a notification portion 410, a tilt sensor 411, and a skin sensor 412 for notifying a user by light emission, display, sound, or the like, in addition to the connection with the solenoid 160 and the operation switch 131.
The solenoid 160 is preferably controlled as follows.
First, the control circuit 40 has a vibration frequency control section 401 as a third control section. The vibration frequency control section 401 can adjust the discharge amount by adjusting the on/off of the current to the solenoid 160 and the polarity inversion frequency. Generally, the lower the frequency, the smaller the discharge amount, and the higher the frequency, the larger the discharge amount.
In the present invention, the preferable range of the vibration frequency is 5 to 30Hz, and if it is lower than 5Hz, stable discharge cannot be obtained, and if it is higher than 30Hz, it is continuously discharged like a general cosmetic liquid, and the discharge amount is too large.
The vibration frequency control section 401 can also change the vibration frequency within an appropriate range by operating the operation switch 131.
As another configuration for adjusting the discharge amount, the stroke (amplitude) and the intensity of the pushing force of the solenoid 160 may be adjusted by the intensity control unit 402 as a fourth control unit. When the voltage applied to the solenoid 160 is increased, the stroke of the solenoid 160 is increased in the maximum stroke range, and the force of pushing (thrust) is also increased. Therefore, the intensity control section 402 can adjust the stroke and the intensity by adjusting the voltage.
For example, the stroke is preferably in the range of 1mm to 3mm, and not only the discharge amount of the cosmetic liquid but also the touch of the user to the skin surface can be adjusted. If a strong tapping feeling is desired, the stroke is set to be large or the pushing force is set to be strong, and if the tapping feeling is desired to be applied to a sensitive portion such as the eye, the pushing force is set to be weak. Preferably, the thrust range may be adjusted in the range of 30% to 100% when the thrust range is 100% at the maximum.
In the structure of the present embodiment including the vibrating portion, the angle of the needle cap 122 is also important. As described above, if it is directed too downward, the discharge amount becomes too large due to gravity, and the liquid is not discharged when facing upward with respect to the horizontal plane. Therefore, the depression angle of the axial direction (the protruding direction of the microneedles) with respect to the horizontal is preferably in the range of 0 to 25 degrees.
Since this angle is important for the liquid injection device 100, the following structure is adopted.
That is, the grip portion 140 and the operating portion 150 are formed so as to be bent at an angle of 55 degrees in the longitudinal direction, and the tip end portion is formed to be slightly downward when the grip portion 140 is gripped. As an angle that tends to become the depression angle described above, it is preferable to set the angle between the grip portion 140 and the action portion 150 to 50 degrees to 80 degrees.
Further, the liquid injection apparatus 100 may be provided with a tilt angle sensor 411 to obtain the angle of the apparatus. The control circuit 400 includes a tilt linkage control unit 403 as a 5 th control unit, and controls the operation of the solenoid 160 when the tilt angle is good or inappropriate according to the tilt angle sensor 411.
For example, the control may be performed so that the operation is performed only when the tilt angle is good, or the control may be performed so that the operation is stopped when the tilt angle is not appropriate. Further, if the tilt angle is good, the notification portion 410 may emit blue light, and if the tilt angle is not appropriate, red light may be emitted to notify the user of the appropriate angle. Further, when the tilt angle is inappropriate, the notification portion 410 may issue a warning sound for notification.
Whether or not to execute the control according to the tilt angle sensor 411 may be switched from the operation switch 131. Depending on the angle of the skin surface to be applied, action may be desired even if the tilt is not appropriate, so the action of the solenoid 160 may be set so as not to stop.
Further, the tilt linkage control unit 403 may set the discharge amount per unit time according to the tilt angle. That is, the discharge amount can be set in the same manner as the discharge amount setting device in the first embodiment, and the discharge amount may be set by instructing the vibration frequency control unit 401 or the intensity control unit 402 to perform control, or by adjusting the vibration frequency, the stroke, the intensity, and the like by the tilt linkage control unit 403.
The working portion 150 has a head 153 at its front end. The head 153 is connected to the housing 152 by a plunger portion 154. The plunger portion 154 holds a rubber O-ring, and even if liquid drops from the needle cap 122, it is sealed so that the liquid does not flow into the inside of the housing 152 due to vibration.
The head 153 includes the skin sensor 412, and the discharge control unit 404 may control the discharge time, as in the head 31 of the first embodiment. That is, the solenoid 160 is triggered by contact with the skin or the like, and the liquid can be discharged from the discharge hole 243 each time the user brings the injection device into contact with the skin.
The control time and the like by the discharge control unit 404 are arbitrary as in embodiment 1.
The head 153 has the skin surface side electrode 155 made of a conductive material, and the grip 140 has the hand electrode 144, thereby achieving various electric beauty effects. For example, a weak current may be applied to the skin surface from the skin surface side electrode 155 to perform an action called iontophoresis that improves the permeability of the cosmetic liquid. At this time, the penetration effect can be further enhanced by the tapping cooperation with the vibrating portion.
Further, an Electrical Muscle Stimulation called EMS (Electrical Muscle Stimulation) and an RF current, for example, a high frequency of about 1Mhz, which is a current having a frequency of several Hz to several kHz, may be applied from the skin surface side electrode.
If a high hardness material such as metal is used as the conductive material of the head 153, pain may be felt when the skin is lightly tapped. Thus, the head 153 may also be made to shake head to ease the impact.
As shown in fig. 16, the skin-side electrode 155 is configured such that a portion thereof can swing within a range of about + -10 degrees on the head 153, avoiding excessive disturbance to the skin.
In the present embodiment, the vibration portion is realized by using a structure of a solenoid, but a mechanism for generating vibration is arbitrary. For example, a vibration motor, ultrasonic vibration, a vibration speaker, a pneumatic vibrator, or the like may be used as appropriate.
Further, the shapes of the force generation mechanism and the main body are not necessarily limited to the above combination. In the structure using the vibrating portion, the housing may be rod-shaped, and in the structure having the sliding portion, a curved body may be used.
Further, as shown in fig. 17, a substantially T-shaped body may also be used. Also in these embodiments, when the vibration part is used, as shown in fig. 17 (a), it is preferable that the angle between the action part 170 and the grip part 171 is constituted to be 70 degrees. However, the structure using the sliding portion is not limited to the structure using the vibrating portion and the other force generating mechanism, and may be any angle such as 90 degrees or 110 degrees as shown in fig. 17 (B) and (C).
Description of reference numerals
1 liquid injection device
10 microneedle
11 discharge hole
20 Cartridge Unit
21 injector part
22 washer section
23 front end portion
30 main body
31 head part
32 housing part
33 electric machine
34 cell
35 control substrate
36 operating switch
37 plunger piston
38 drive shaft
39 connecting shaft
40 control circuit
41 discharge speed adjusting part
42 extrusion amount control part
43 discharge control part
44 origin sensor
45 skin sensor
100 liquid injection device
120 cartridge unit
121 container part
122 needle cap
124 discharge hole
130 body
131 operating switch
140 grip part
141 casing
142 cell
143 control substrate
144 hand electrode
150 acting part
151 mounting part
152 housing
153 head
154 plunger portion
155 skin surface side electrode
160 solenoid
161 joint
162 slide block
163 outer cylinder
400 control circuit
401 vibration frequency control unit
402 intensity control part
403 tilt linkage control unit
404 discharge control unit
410 notification unit
411 inclination angle sensor
412 skin sensor
Claims (22)
1. A liquid injection device for injecting liquid into skin by a microneedle, comprising a cartridge unit and a main body,
the cartridge unit includes the microneedle, a discharge hole for discharging the liquid, and a container section for containing the liquid;
the main body is provided with:
a cartridge mounting part to which the cartridge unit is detachably mounted,
a force generating mechanism that generates a discharging action of the liquid with respect to the cartridge unit mounted;
the cartridge unit can be replaced and used.
2. The liquid injection apparatus of claim 1,
in the cartridge unit, the microneedle and the discharge hole are provided at a distal end portion, and the distal end portion is attached to the container portion and used.
3. The liquid injection apparatus according to claim 1 or 2,
the liquid injection device is provided with a discharge amount setting device for setting a discharge amount when the liquid is discharged from the cartridge unit.
4. The liquid injection apparatus of claim 3,
the discharge amount setting means sets the discharge amount per unit time by changing the state of the discharge hole in accordance with the characteristic of the liquid.
5. The liquid injection apparatus according to any one of claims 1 to 4,
the container portion of the cartridge unit includes at least a syringe portion and a gasket portion for extruding the liquid from the syringe portion to the discharge hole,
the urging force generating mechanism includes a sliding portion for axially moving the washer portion of the attached cartridge unit.
6. The liquid injection apparatus of claim 5,
the liquid injection device includes a discharge frequency setting device for setting the frequency of discharging the liquid from the cartridge unit.
7. The liquid injection apparatus according to claim 5 or 6,
the liquid injection device includes a driving device for driving the sliding portion of the liquid injection device in an axial direction.
8. The liquid injection apparatus as claimed in claims 3 and 7,
the discharge amount setting device includes a first control unit that sets a discharge amount per unit time by controlling a driving speed of the driving device.
9. The liquid injection apparatus as claimed in claims 3 and 7,
the discharge amount setting device includes a second control unit that adjusts the amount of extrusion of the gasket unit by the driving device.
10. The liquid injection apparatus according to any of claims 7 to 9,
the driving device is a motor having a driving shaft for driving the sliding portion in the axial direction.
11. The liquid injection apparatus according to any one of claims 5 to 10,
the liquid injection device is provided with an operation unit for manually operating the slide unit.
12. The liquid injection apparatus according to any one of claims 1 to 4,
the urging force generating mechanism includes a vibrating portion configured to vibrate the cartridge unit in an axial direction.
13. The liquid injection apparatus of claim 12,
the vibration control device is provided with a third control unit that sets the vibration frequency of the vibration unit in the acting force generation mechanism.
14. The liquid injection apparatus as claimed in any of claims 1 to 13,
the liquid injection device is provided with a fourth control unit that controls the force applied from the urging force generation mechanism to the cartridge unit.
15. The liquid injection apparatus as claimed in any of claims 1 to 14,
the main body of the liquid injection device is composed of a holding part for holding by a user and an action part at least provided with the cartridge installation part,
the included angle between the holding part and the acting part in the length direction is 50-80 degrees.
16. The liquid injection apparatus as claimed in any of claims 1 to 15,
the liquid injection device is provided with a fifth control unit which detects the tilt angle of the main body and controls the tilt angle to be activated or notifies a user when the tilt angle is within a predetermined angle range.
17. The liquid injection apparatus of claim 16,
the fifth control portion sets a discharge amount per unit time according to the detected inclination angle of the main body.
18. The liquid injection apparatus according to any one of claims 1 to 17, comprising:
a skin sensor detecting proximity or contact of the microneedle to the skin in the vicinity of the microneedle,
and a sixth control unit for controlling the acting force generating mechanism according to the detection result.
19. The liquid injection apparatus of claim 12,
in the cartridge unit, there are a plurality of the discharge holes arranged at intervals ranging from 2mm to 20 mm.
20. A system using the liquid injection apparatus as claimed in any one of claims 1 to 19,
comprises a plurality of cartridge units respectively containing more than two liquids with different efficacies and a main body,
various effects are provided by replacing the cartridge unit and using it.
21. A system using the liquid injection apparatus as claimed in any one of claims 1 to 19,
the cartridge unit includes a plurality of cartridge units each having microneedles different in at least one of length, arrangement density, and distribution area, and the main body includes a plurality of microneedles,
various effects are provided by replacing the cartridge unit and using it.
22. The system of claim 20 or 21,
in the system, the microneedle and the discharge hole are provided at the distal end portion, and in a configuration in which the distal end portion is used by being attached to the container portion, various effects are provided by replacing the distal end portion and using it, instead of replacing the cartridge unit.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020-114884 | 2020-07-02 | ||
| JP2020114884 | 2020-07-02 | ||
| PCT/JP2021/025124 WO2022004876A1 (en) | 2020-07-02 | 2021-07-02 | Liquid injection device, and system and cartridge unit therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115397502A true CN115397502A (en) | 2022-11-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180028185.5A Pending CN115397502A (en) | 2020-07-02 | 2021-07-02 | Liquid injection device, system thereof and cartridge unit |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPWO2022004876A1 (en) |
| CN (1) | CN115397502A (en) |
| WO (1) | WO2022004876A1 (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1571685A (en) * | 2001-09-12 | 2005-01-26 | 贝克顿迪肯森公司 | Microneedle-based pen device for drug delivery and method for using same |
| US20150045729A1 (en) * | 2011-04-20 | 2015-02-12 | Amgen, Inc. | Autoinjector apparatus |
| JP2015217176A (en) * | 2014-05-19 | 2015-12-07 | 株式会社根本杏林堂 | Chemical feeder |
| KR20160007337A (en) * | 2014-07-11 | 2016-01-20 | 주식회사 현대메디텍 | Sylinge connecting type autometic drug injection apparatus |
| US20180140778A1 (en) * | 2015-04-16 | 2018-05-24 | Nemoto Kyorindo Co., Ltd. | Chemical liquid injector, method for controlling chemical liquid injector, and computer program |
| KR20200019399A (en) * | 2018-08-14 | 2020-02-24 | 주식회사 브리텍 | Skin Beauty Applicator in use with Micro Needle |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL156245A0 (en) * | 2000-12-22 | 2004-01-04 | Dca Design Int Ltd | Drive mechanism for an injection device |
| PT3185934T (en) * | 2014-08-28 | 2018-10-19 | Unl Holdings Llc | Skin sensors for drug delivery devices |
-
2021
- 2021-07-02 CN CN202180028185.5A patent/CN115397502A/en active Pending
- 2021-07-02 WO PCT/JP2021/025124 patent/WO2022004876A1/en active Application Filing
- 2021-07-02 JP JP2022534125A patent/JPWO2022004876A1/ja active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1571685A (en) * | 2001-09-12 | 2005-01-26 | 贝克顿迪肯森公司 | Microneedle-based pen device for drug delivery and method for using same |
| US20150045729A1 (en) * | 2011-04-20 | 2015-02-12 | Amgen, Inc. | Autoinjector apparatus |
| JP2015217176A (en) * | 2014-05-19 | 2015-12-07 | 株式会社根本杏林堂 | Chemical feeder |
| KR20160007337A (en) * | 2014-07-11 | 2016-01-20 | 주식회사 현대메디텍 | Sylinge connecting type autometic drug injection apparatus |
| US20180140778A1 (en) * | 2015-04-16 | 2018-05-24 | Nemoto Kyorindo Co., Ltd. | Chemical liquid injector, method for controlling chemical liquid injector, and computer program |
| KR20200019399A (en) * | 2018-08-14 | 2020-02-24 | 주식회사 브리텍 | Skin Beauty Applicator in use with Micro Needle |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022004876A1 (en) | 2022-01-06 |
| JPWO2022004876A1 (en) | 2022-01-06 |
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