CN115382089A - Automatic contrast agent supplementing method and device matched with ultrasonic transdermal drug delivery device - Google Patents
Automatic contrast agent supplementing method and device matched with ultrasonic transdermal drug delivery device Download PDFInfo
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- CN115382089A CN115382089A CN202211056359.1A CN202211056359A CN115382089A CN 115382089 A CN115382089 A CN 115382089A CN 202211056359 A CN202211056359 A CN 202211056359A CN 115382089 A CN115382089 A CN 115382089A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Abstract
The invention discloses a method and a device for automatically supplementing a contrast agent matched with an ultrasonic transdermal drug delivery device, and belongs to the technical field of ultrasonic transdermal drug delivery devices. Firstly, the diagnosis and treatment integrated host acquires the initial amplitude of each depth pixel of an image, records the real-time amplitude of each depth pixel in the treatment process, automatically judges whether the contrast agent needs to be supplemented or not through an algorithm, and timely supplements the contrast agent through an input pipe orifice connected with a drug administration pool. The invention can observe the consumption condition of the contrast agent in real time in the whole course, flexibly supplements the contrast agent according to the actual condition at each depth on the premise of not changing the relative position relation of the probe and the treatment area, avoids the influence of subjective evaluation of operators, ensures the consistency and scientificity of the whole treatment process, and is beneficial to enhancing the effect of the ultrasonic combined contrast agent transdermal administration treatment means.
Description
Technical Field
The invention belongs to the technical field of ultrasonic transdermal drug delivery devices, and particularly relates to a method and a device for automatically supplementing a contrast agent matched with an ultrasonic transdermal drug delivery device.
Background
Transdermal administration refers to a method of administering a drug to the surface of the skin such that the drug passes through the skin at a constant rate (or near constant rate) and into the systemic circulation to produce a systemic or local therapeutic effect. Transdermal administration has many advantages: the drug absorption is not influenced by factors such as pH, food, transport time and the like in the digestive tract; the first pass effect of the liver is avoided; the adverse reaction caused by overhigh blood concentration due to too fast absorption is overcome; the drug administration speed can be continuously controlled, the drug administration is flexible, and the like. However, the skin has a specific barrier function, which effectively limits the exchange of substances with the external environment and the penetration of foreign compounds. While protecting the human body, the skin barrier also blocks the passage of macromolecular drugs into the human body.
The ultrasound combined contrast agent microbubble is a new non-invasive means for effectively enhancing transdermal drug delivery, and has the advantages of no damage to human bodies, simple operation and wide clinical application. However, contrast agents rapidly deplete at a certain ultrasound intensity and impair the effectiveness of ultrasound transdermal delivery. It is therefore desirable to monitor and replenish fresh contrast agent in real time during the course of treatment. In the existing transdermal administration method of the ultrasonic combined contrast agent, an ultrasonic diagnosis and treatment integrated machine is generally used, and the condition of the contrast agent is monitored through the imaging function of a host machine while treatment is carried out. The probe of the diagnosis and treatment integrated machine is contacted with the upper surface of the contrast agent solution, the contrast agent solution is contained in the hollow well-shaped contrast agent application pool, and the lower surface of the diagnosis and treatment integrated machine can be attached to the skin to be treated. Due to the limitation of external superficial treatment, the method can not provide continuous microbubbles of the contrast agent by intravenous injection in the treatment process like in vivo tumor treatment and other scenes, the conventional method generally lifts the treatment ultrasonic probe frequently to directly supplement the liquid for the contrast agent application pool, but air is mixed between the probe and the contrast agent, the probe is damaged, and the position relation between the probe and the treatment area is also changed. In addition, the method of injecting the liquid supplement into the contrast agent application pool through the needle tube can avoid air mixing, but can not grasp the residual contrast agent in the contrast agent application pool in real time, so that the dosage of the newly added contrast agent can not be quantified, and the stability of the whole treatment process is influenced.
The existing ultrasonic combined contrast agent transdermal administration treatment needs a novel method and a novel device which can automatically judge the residual content of the contrast agent in real time and directly supplement the contrast agent in the treatment process.
Disclosure of Invention
The invention aims to provide an automatic contrast agent supplementing device matched with an ultrasonic transdermal administration device and a method, and aims to solve the technical problem of automatic contrast agent supplementing in the conventional ultrasonic combined contrast agent transdermal administration treatment.
In order to realize the purpose, the invention adopts the following technical scheme: the automatic contrast agent supplementing method matched with the ultrasonic transdermal drug delivery device is characterized in that: the method specifically comprises the following steps:
s1: the diagnosis and treatment integrated host and the probe acquire images of treatment areas in real time and record pixel information of the images, and the diagnosis and treatment integrated host calculates and records the amplitude sum A of initial pixels at each depth i (i＝1,2,…,n)；
S2: at preset time intervals, the diagnosis and treatment integrated host and the probe acquire images of the treatment area in real time and record pixel information of the images, and the diagnosis and treatment integrated host calculates and records the amplitude sum B of real-time pixels at various depths i (i＝1,2,…,n)；
S3: the diagnosis and treatment integrated host machine judges whether a contrast medium solution needs to be supplemented or not;
s4: the contrast agent automatic replenishment system inputs a fresh contrast agent solution into the contrast agent administration reservoir.
Further, the method for automatically supplementing the contrast medium matched with the ultrasound transdermal drug delivery device comprises the following specific steps: on an ultrasonic image acquired by a diagnosis and treatment integrated host, n rectangular frames with the width of the full width of the image and the height of h are sequentially selected from the upper surface of the skin as a starting point in the direction close to a probe, and the initial pixel amplitude sum A in each depth rectangular frame is calculated i (i＝1,2,…,n)。
Further, the method for automatically supplementing the contrast medium matched with the ultrasound transdermal drug delivery device comprises the following specific steps of: on an ultrasonic image acquired by a diagnosis and treatment integrated host, taking the upper surface of skin as a starting point, sequentially selecting n rectangular frames with the width of the full width of the image and the height of h from the direction close to a probe, and calculating the real-time pixel amplitude sum B in each depth rectangular frame i (i＝1,2,…,n)。
Further, in the method for automatically replenishing a contrast medium matched with an ultrasound transdermal drug delivery device, the judgment criterion in step S3 is as follows: b i ≤0.5A i (i＝1,2,…,n)；
Sequentially judging n times in total, when the formula is met, indicating that the contrast agent needs to be supplemented, recording the depth corresponding to the i at the moment, and continuing to execute S4; and if all the n times of judgment do not satisfy the above expression, executing S2.
Further, in the method for automatically supplementing a contrast medium matched with an ultrasound transdermal drug delivery device, the specific method in step S4 is: and after obtaining the depth information transmitted by the diagnosis and treatment integrated host, the automatic contrast medium supplementing system discharges the waste contrast medium through the output pipe orifice, the discharged volume of the waste contrast medium is equal to (1/2 n) ± (10%) of the initial volume of the contrast medium, supplements an equal amount of fresh contrast medium through the input pipe orifice at a corresponding depth position, and continues to execute S2 after supplementing.
Further, in the method for automatically replenishing a contrast medium matched with an ultrasonic transdermal drug delivery device, the interval h ranges from: h is more than or equal to 1mm and less than or equal to 10mm.
The contrast agent automatic supplementing device matched with the ultrasonic transdermal drug delivery device is characterized in that: the device comprises: the diagnosis and treatment integrated main machine is connected with the probe, the probe is attached to the contrast agent application pool, the contrast agent application pool is connected with the contrast agent automatic supplement system, and the contrast agent automatic supplement system is connected with the diagnosis and treatment integrated main machine.
Further, the contrast agent automatic replenishing device matched with the ultrasonic transdermal drug delivery device is characterized in that the contrast agent application pool is a hollow container filled with contrast agent solution, and the lower end of the contrast agent application pool can be tightly attached to the skin surface of a treatment area; the contrast agent application pool is vertically provided with n contrast agent input pipe orifices along the side wall of one side of the ultrasonic wave emitted by the probe, and the circle centers of adjacent pipe orifices are separated by h; an output orifice is provided at the opposite side thereof.
Further, the contrast medium automatic replenishment device matched with the ultrasonic transdermal drug delivery device comprises a flow pump with a plurality of valves, wherein the valves are connected to the input pipe orifices of the fresh contrast medium in a one-to-one correspondence manner, and the control circuit controls the opening and closing, and the opening and closing time of each valve.
The invention has the advantages that: firstly, the diagnosis and treatment integrated host collects the initial amplitude of each depth pixel of an image, records the real-time amplitude of each depth pixel in the treatment process, automatically judges whether the contrast agent needs to be supplemented or not through an algorithm, and timely supplements the contrast agent through an input pipe orifice connected with a drug administration pool. The invention can observe the consumption condition of the contrast agent in real time in the whole course, flexibly supplements the contrast agent according to the actual condition at each depth on the premise of not changing the relative position relation of the probe and the treatment area, avoids the influence of subjective evaluation of operators, ensures the consistency and scientificity of the whole treatment process, and is beneficial to enhancing the effect of the ultrasonic combined contrast agent transdermal administration treatment means.
Drawings
Fig. 1 is a schematic structural view of an automatic contrast medium replenishing device matched with an ultrasonic transdermal drug delivery device according to the present invention.
Fig. 2 is a schematic structural view of the drug delivery pool in fig. 1.
Fig. 3 is a schematic flow chart of the method for automatically replenishing the contrast medium matched with the ultrasonic transdermal drug delivery device according to the invention.
Description of the reference numerals: the diagnosis and treatment integrated system comprises a diagnosis and treatment integrated main machine 1, a probe 2, a contrast agent administration pool 3, a contrast agent automatic replenishment system 4, a fresh contrast agent input pipe orifice 31, a contrast agent waste liquid output pipe orifice 32 and a contrast agent 33.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments.
Example 1: in medicine, ultrasound contrast agents are often used to enhance the visualization of blood flow, enhance the effect of ultrasound therapy, and the like. Since the scattering of the ultrasound wave by the contrast agent is very strong, the contrast agent will appear as a brighter scattering point in the image displayed by the ultrasound imaging apparatus, and the more the contrast agent, the higher the pixel amplitude of the corresponding ultrasound image area. The amplitude of the ultrasound image pixels can therefore be used to characterize the contrast agent content. Meanwhile, the contrast agent with higher level can play a role of enhancing the effect of ultrasonic transdermal drug delivery. Therefore, in the ultrasonic transdermal drug delivery treatment, the content of the contrast agent solution needs to be monitored in real time and kept at a high level by means of fluid replacement.
Referring to fig. 1, the present invention provides an apparatus for automatically replenishing a contrast medium in an ultrasonic transdermal drug delivery device, the apparatus including: diagnose integrative host computer 1, probe 2, contrast medium and give medicine to the pond 3, the automatic complementary system 4 of contrast medium, diagnose integrative host computer 1 and probe 2 and be connected, probe 2 and the laminating of contrast medium pond 3 of giving medicine to the pond, contrast medium pond 3 of giving medicine to the pond is connected with the automatic complementary system 4 of contrast medium, contrast medium automatic complementary system 4 is connected with diagnosing integrative host computer 1.
Referring to fig. 2, the contrast agent dispensing pool 3 in this embodiment is a hollow cylindrical container with a radius of 20mm and a height of 40mm. 8 contrast agent input pipe orifices 31 with the radius of 2mm are vertically arranged on the side wall of one side of the contrast agent administration pool along the direction of the ultrasonic wave transmitted by the probe, and the circle centers of the pipe orifices are 5mm apart; on its opposite side, 1 outlet duct 32 with a radius of 2mm is provided. The contrast agent application reservoir is filled with a contrast agent solution 33 and has a lower end that is in close proximity to the skin surface of the treatment area.
Specifically, the contrast medium automatic replenishment system comprises a flow pump with 8 valves, the valves are connected to 8 fresh contrast medium inlet pipes in a one-to-one correspondence manner, and the contrast medium automatic replenishment system controls the opening and closing, and the opening and closing time of the 8 valves through a control circuit.
Referring to fig. 3, in the method for automatically replenishing the contrast agent in the ultrasound transdermal drug delivery device of the present embodiment, when the method is implemented, the contrast agent application pool is first attached to the skin of the treatment area, 50.24ml of fresh contrast agent solution is injected into the contrast agent application pool, and the space between the skin and the probe is filled with the contrast agent solution, so that no air exists between the probe and the skin.
The ultrasonic diagnosis and treatment integrated host and the probe provided by a certain enterprise acquire images of treatment areas in real time, and the real-time ultrasonic images displayed by the diagnosis and treatment integrated host are as follows: rectangular image with a width of 40mm and a depth of 50 mm. On this image, the skin is located 40mm below the probe surface. 8 rectangular frames with the width of 40mm and the height of 5mm are sequentially selected towards the direction close to the probe by taking the upper surface of the skin as a starting point. With reference to Table 1, the sum of the amplitudes of the initial pixels in each depth rectangular frame is A calculated by the diagnosis and treatment machine i (i＝1,2,…,8)。
Table 1:
every 30 seconds, the above operation is repeated and the real-time pixel amplitude sum Bi of each depth is recorded (i =1,2, \8230;, 8). As can be seen from table 1, at 60 seconds, the contrast agent is consumed more at the depths of 2.5mm, 7.5mm and 12.5mm from the upper surface of the skin, and the real-time pixel amplitude sum is already lower than half of the original pixel amplitude sum at the corresponding positions, so that the contrast agent needs to be supplemented at the three depth positions. Indicating that the contrast agent is more easily consumed near the skin.
The integrated unit will discharge 3.14ml (total 9.42 ml) of the original contrast medium three times by opening the valve connected to the output nozzle. Meanwhile, the three depth positions of 2.5mm, 7.5mm and 12.5mm are transmitted to an automatic contrast medium supplementing system, and the system opens valves connected with the 1 st, 2 nd and 3 rd input nozzles with corresponding depths, and each valve is supplemented with 3.14ml of fresh contrast medium. All valves are then closed, the contrast content is continuously monitored and the above steps are repeated.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It should be understood by those skilled in the art that the above embodiments do not limit the scope of the present invention in any way, and all technical solutions obtained by using equivalent substitution methods fall within the scope of the present invention.
The parts not involved in the present invention are the same as or can be implemented using the prior art.
Claims (9)
1. The automatic contrast agent supplementing method matched with the ultrasonic transdermal drug delivery device is characterized in that: the method specifically comprises the following steps:
s1: the diagnosis and treatment integrated host and the probe acquire images of treatment areas in real time and record pixel information of the images, and the diagnosis and treatment integrated host calculates and records the amplitude sum A of initial pixels at each depth i （i=1,2,…,n）；
S2: every preset time, diagnosis and treatment are integratedThe host and the probe acquire images of the treatment area in real time and record pixel information thereof, and the diagnosis and treatment integrated host calculates and records the amplitude sum B of real-time pixels at all depths i （i=1,2,…,n）；
S3: the diagnosis and treatment integrated host machine judges whether a contrast agent solution needs to be supplemented or not;
s4: the contrast agent automatic replenishment system inputs a fresh contrast agent solution into the contrast agent administration reservoir.
2. The method for automatically replenishing a contrast medium mated with an ultrasonic transdermal drug delivery device according to claim 1, wherein: the specific method of the step S1 is as follows: on an ultrasonic image acquired by a diagnosis and treatment integrated host, taking the upper surface of skin as a starting point, sequentially selecting n rectangular frames with the width of the full width of the image and the height of h from the direction close to a probe, and calculating the initial pixel amplitude sum A in each depth rectangular frame i （i=1,2,…,n）。
3. The method for automatically replenishing a contrast medium mated with an ultrasonic transdermal drug delivery device according to claim 1, wherein: the specific method of the step S2 is as follows: on an ultrasonic image acquired by a diagnosis and treatment integrated host, n rectangular frames with the width of the full width of the image and the height of h are sequentially selected from the upper surface of the skin as a starting point in the direction close to a probe, and the real-time pixel amplitude sum B in each depth rectangular frame is calculated i （i=1,2,…,n）。
4. The method for automatically replenishing a contrast medium mated with an ultrasonic transdermal drug delivery device according to claim 1, wherein: the judgment criterion in step S3 is as follows: b is i ≤0.5A i （i=1,2,…,n）；
Sequentially judging n times in total, when the formula is met, indicating that the contrast agent needs to be supplemented, recording the depth corresponding to the i at the moment, and continuing to execute S4; and if all the n times of judgment do not satisfy the formula, executing S2.
5. The method for automatically supplementing a contrast medium matched with an ultrasonic transdermal drug delivery device according to claim 1, wherein the specific method in step S4 comprises the following steps: and after the contrast agent automatic supplementing system obtains the depth information transmitted by the diagnosis and treatment integrated host, discharging contrast agent waste liquid through an output pipe orifice, wherein the discharge volume of the contrast agent waste liquid is equal to (1/2 n) ± (10%) of the volume of the initial contrast agent, supplementing an equivalent amount of fresh contrast agent through the input pipe orifice at a corresponding depth position, and continuing to execute S2 after supplementing.
6. The method for automatically replenishing contrast medium in an ultrasonic transdermal delivery device according to claim 2, wherein the interval h is in the range of: h is more than or equal to 1mm and less than or equal to 10mm.
7. The contrast agent automatic supplementing device matched with the ultrasonic transdermal drug delivery device is characterized in that: the device comprises: the diagnosis and treatment integrated main machine is connected with the probe, the probe is attached to the contrast agent application pool, the contrast agent application pool is connected with the contrast agent automatic supplement system, and the contrast agent automatic supplement system is connected with the diagnosis and treatment integrated main machine.
8. The apparatus for automatically replenishing a contrast medium in an ultrasonic transdermal drug delivery device according to claim 7, wherein: the contrast agent application pool is a hollow container, wherein the hollow container is filled with contrast agent solution, and the lower end of the hollow container can be tightly attached to the skin surface of the treatment area; n contrast agent input pipe orifices are vertically arranged on the side wall of the contrast agent administration pool along one side of the ultrasonic wave emitted by the probe, and the circle centers of adjacent pipe orifices are separated by h; an output orifice is provided at the opposite side thereof.
9. The apparatus for automatically replenishing a contrast medium mated with an ultrasonic transdermal drug delivery apparatus according to claim 7, wherein: the contrast medium automatic replenishing system comprises a flow pump with a plurality of valves, wherein the valves are connected to the fresh contrast medium input pipe orifices in a one-to-one correspondence mode, and the opening and closing time of each valve are controlled through a control circuit.
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