CN115382037A

CN115382037A - Fluid replacement control method for blood purification apparatus, and computer-readable storage medium

Info

Publication number: CN115382037A
Application number: CN202210929619.5A
Authority: CN
Inventors: 董凡; 区子友; 郭瑶; 宋小刚; 宋先新
Original assignee: Beijing Jafron Medical Equipment Co Ltd
Current assignee: Beijing Jafron Medical Equipment Co Ltd
Priority date: 2022-08-03
Filing date: 2022-08-03
Publication date: 2022-11-25

Abstract

The invention provides a fluid infusion control method of blood purification equipment, the blood purification equipment and a computer readable storage medium, wherein the fluid infusion control method comprises the following steps: controlling the blood purifier to perform blood purification operation; acquiring a first weight W1 of the fluid infusion bag detected by a first weighing scale; if the first weight W1 is determined to be larger than the first preset weight, the heating device is controlled to be started to heat the fluid infusion bag, the heating power of the heating device is subjected to feedback adjustment according to the first weight W1, and the heating power and the first weight W1 are subjected to feedback adjustment in a direct proportion relation; when a fluid replacement operation instruction is obtained, detecting a first temperature T1 of a replacement fluid in a fluid replacement bag, and detecting a second temperature T2 of blood in an extracorporeal blood circuit of the blood purifier; and judging whether the absolute value of T1-T2 is less than or equal to delta T1, if so, outputting the supplementary liquid into the extracorporeal blood circuit. The fluid replacement control method of the blood purification equipment can effectively ensure that the temperature of the fluid replacement is stably maintained in a safe temperature range.

Description

Fluid replacement control method for blood purification apparatus, and computer-readable storage medium

Technical Field

The present invention relates to the field of control technologies for blood purification apparatuses, and in particular, to a fluid replacement control method for a blood purification apparatus, a blood purification apparatus implementing the fluid replacement control method, and a computer-readable storage medium.

Background

The blood purification treatment belongs to one of kidney substitution treatment methods, wherein human blood is led out to an extracorporeal blood circuit by a blood purification device, specific molecular substances (such as toxins and the like) in the blood are filtered by a blood purifier in the extracorporeal blood circuit, meanwhile, some supplementary liquid containing substances required by a human body is added into the purified blood by a supplementary branch in the extracorporeal blood circuit, and then the purified blood is returned to the human body so as to achieve the purposes of purifying the blood and treating diseases. At present, the blood purification equipment can be widely applied to the fields of rescue and treatment of acute and severe patients with acute and chronic renal insufficiency, multi-organ dysfunction syndrome, systemic inflammatory response syndrome, fulminant hepatic failure, severe hemorrhagic necrotizing pancreatitis and the like, and in the clinical treatment process, different blood purification treatment modes can be selected according to the clinical treatment requirements of the patients, such as: a slow continuous ultrafiltration treatment mode, a hemodiafiltration treatment mode, a hemodialysis treatment mode, a hemoperfusion treatment mode and the like, and under the selected blood purification treatment mode, the blood purification treatment function can be realized by using the blood purification equipment.

When the blood of a human body is led out of the body, the temperature of the blood of the human body is very easy to drop, the supplementary liquid belongs to external liquid, the temperature of the blood can be changed when the supplementary liquid is added into the purified blood, and if the blood which does not meet the safety standard of the physiological temperature of the human body is directly returned into the human body, uncomfortable symptoms can be caused to the human body, and the life safety of a patient can be seriously threatened.

In order to solve the problem of the temperature reduction of extracorporeal blood in the blood purification treatment process, the conventional blood purification equipment is provided with a heater on a supplementing branch in an extracorporeal blood circuit, and supplementing liquid in the supplementing branch is heated and then added into purified blood, so that the purified blood can meet the safety standard of human physiological temperature. However, the heater on the existing supplementing branch adopts manual control to adjust the heating temperature, so that the heating effect of the supplementing liquid is not good, for example, the temperature of the heated supplementing liquid is too high or too low, and the output capacity of the supplementing liquid can also change in the blood purification treatment process, which causes great difficulty in controlling the heating of the supplementing liquid, cannot stably maintain the purified blood in the safe temperature range required by the user, and reduces the temperature safety of the blood returned to the human body in the blood purification treatment process.

Disclosure of Invention

The first purpose of the present invention is to provide a fluid replacement control method for blood purification equipment, which can effectively ensure that the temperature of a fluid replacement is stably maintained within a safe temperature range, so as to improve the heating safety and the heating control efficiency of the fluid replacement, and add the fluid replacement with a stable heating temperature to purified blood, so that the blood purification treatment process has higher safety, the risk of temperature safety of the blood returned to a human body in the blood purification treatment process is reduced, and the problems of low heating control efficiency and low heating safety of the existing blood purification equipment are overcome.

The second purpose of the invention is to provide a blood purification device for realizing the fluid replacement control method.

A third object of the present invention is to provide a computer-readable storage medium for implementing the fluid replacement control method.

In order to achieve the first object of the present invention, the present invention provides a fluid replacement control method for a blood purification apparatus, wherein a first weighing scale of the blood purification apparatus is provided with a heating device, the first weighing scale is used for placing a fluid replacement bag, the first weighing scale is used for detecting the weight of the fluid replacement bag, the heating device is used for heating the fluid replacement bag, and the fluid replacement control method for the blood purification apparatus comprises: controlling the blood purifier to perform blood purification operation; acquiring a first weight W1 of the fluid infusion bag detected by a first weighing scale; if the first weight W1 is larger than the first preset weight, controlling the heating device to start heating the fluid infusion bag, and simultaneously performing feedback adjustment on the heating power of the heating device according to the first weight W1, wherein the heating power and the first weight W1 are in a direct proportion relationship to perform feedback adjustment; when a fluid replacement operation instruction is obtained, detecting a first temperature T1 of a replacement fluid in a fluid replacement bag, and detecting a second temperature T2 of blood in an extracorporeal blood circuit of the blood purifier; and judging whether the absolute value of T1-T2 is less than or equal to delta T1, if so, outputting the supplementary liquid into the extracorporeal blood circuit, wherein the delta T1 is a first preset temperature difference value.

According to the scheme, the fluid infusion control method of the blood purification equipment performs feedback adjustment on the heating power of the heating device according to the first weight W1 of the fluid infusion bag, so that the heating temperature of the heating device and the first weight W1 of the fluid infusion bag can be maintained in a relatively stable state, the temperature of the supplementary fluid can be effectively maintained in a safe temperature range, the heating safety and the heating control efficiency of the supplementary fluid are improved, the supplementary fluid with stable heating temperature is added into purified blood, the blood purification treatment process has higher safety, the temperature safety risk of the blood which is returned to a human body in the blood purification treatment process is reduced, and the problems of low heating control efficiency and low heating safety of the existing blood purification equipment are solved. Compared with the existing heater which can only heat the supplementary liquid in the supplementary branch and can not heat the supplementary liquid in the supplementary liquid bag, the blood purification equipment of the invention arranges the heating device on the first weighing scale, thus having two effects: 1. the space layout of the blood purification equipment is saved, the structure of the blood purification equipment is simplified, and the structure of the blood purification equipment is more miniaturized; 2. place on first weighing scale when the fluid infusion bag, can directly heat the supplementary liquid in the fluid infusion bag to make the supplementary liquid in the fluid infusion bag maintain at stable state, the supplementary liquid after the heating is directly exported to the blood return circuit on, has improved the heating convenience and the heating control stability of supplementary liquid.

Further, when the first temperature T1 is judged to be higher than the preset warning temperature T, the blood purifying apparatus is controlled to stop the blood purifying operation.

In a further aspect, the blood purifier of the blood purification apparatus is a filter, a waste liquid output end of the filter outputs waste liquid, and the fluid replacement control method of the blood purification apparatus further comprises: detecting a third temperature T3 of the waste liquid; judging whether the absolute value T1-T3 is less than or equal to delta T2, if not, controlling the blood purification equipment to send out a filter fault signal; wherein Δ T2 is a second predetermined temperature difference.

According to a further scheme, the blood purification equipment further comprises a second weighing scale, wherein the second weighing scale is used for placing the waste liquid bag and detecting the weight of the waste liquid bag, and the waste liquid bag is communicated with the waste liquid output end of the filter and used for collecting waste liquid; the fluid infusion control method of the blood purification device further comprises the following steps: acquiring a second weight W2 of the waste liquid bag detected by the second weighing scale; calculating and acquiring the weight increasing rate rho 1 of the waste liquid bag according to the second weight W2, and calculating and acquiring the weight decreasing rate rho 2 of the fluid infusion bag according to the first weight W1; judging whether | rho 1-rho 2| ≧ Δ rho is satisfied, if so, judging that the liquid of the filter is in an unbalanced state; wherein Δ ρ is a preset weight change rate.

Further, the blood purifier of the blood purification device is a dialyzer, dialysate is input to a dialysate input end of the dialyzer, and recovery liquid is output to a dialysate output end of the dialyzer, and the fluid replacement control method of the blood purification device further comprises: detecting a first liquid flow Q2 of the dialysate and a second liquid flow Q3 of the recovery liquid; judging whether | Q2-Q3| ≧ Δ Q, if yes, controlling the blood purification equipment to send a dialyzer liquid imbalance fault signal; wherein Δ Q is a preset liquid flow rate.

The further scheme is that whether | Q2-Q3| ≧ Δ Q is judged, and if not, the fluid infusion control method of the blood purification device further comprises the following steps: detecting a fourth temperature T4 of the dialysate and detecting a fifth temperature T5 of the recovery liquid; judging whether absolute T4-T5 is less than or equal to delta T3, and if not, judging that the dialysis temperature fault of the dialyzer occurs; wherein Δ T3 is a third predetermined temperature difference.

In a further aspect, the fluid replacement control method for a blood purification apparatus further includes: the preset guard temperature T = T5+2 × (T4-T5) is reset.

According to a further scheme, the blood purification equipment further comprises a third weighing scale and a fourth weighing scale, wherein the third weighing scale is used for placing a dialysate bag and detecting the weight of the dialysate bag, the dialysate bag is communicated with a dialysate input end of a dialyzer and used for supplying dialysate, the fourth weighing scale is used for placing a liquid storage bag and detecting the weight of the liquid storage bag, and the liquid storage bag is communicated with a dialysate output end of the dialyzer and used for collecting recovery liquid; the fluid infusion control method of the blood purification device further comprises the following steps: acquiring a third weight W3 of the dialysate bag detected by the third weighing scale, and calculating and acquiring a weight reduction rate rho 3 of the dialysate bag according to the third weight W3; acquiring a fourth weight W4 of the liquid storage bag detected by the fourth weighing scale, and calculating and acquiring a weight increasing rate rho 4 of the liquid storage bag according to the fourth weight W4; when the weight increasing rate rho 4 of the liquid storage bag is greater than the weight decreasing rate rho 3 of the dialysate bag, increasing the preset warning temperature t on the basis of resetting; or when the weight increasing rate rho 4 of the liquid storage bag is smaller than the weight reducing rate rho 3 of the dialysate bag, the preset warning temperature t is reduced on the basis of resetting.

In order to achieve the second object of the present invention, the present invention provides a blood purification apparatus, which includes a host and a display screen, wherein a circuit board capable of implementing interactive communication with the display screen is disposed in the host, a processor and a memory are disposed on the circuit board, the memory stores a computer program, and the computer program implements the steps of the fluid infusion control method of the blood purification apparatus when executed by the processor.

In order to achieve the third object of the present invention, the present invention provides a computer-readable storage medium having stored thereon a computer program which, when being executed by a processor, realizes the respective steps of the above-mentioned fluid replacement control method for a blood purification apparatus.

Drawings

Fig. 1 is a structural view of an embodiment of the blood purification apparatus of the present invention.

Fig. 2 is a schematic diagram of the operation of an embodiment of the blood purification apparatus of the present invention.

Fig. 3 is a flowchart of an embodiment of the fluid replacement control method of the blood purification apparatus of the present invention.

Fig. 4 is a graph showing the relationship between the real-time flow rate of blood in the extracorporeal blood circuit and the substitution flow rate of the substitution liquid in the embodiment of the substitution control method for the blood purification apparatus according to the present invention.

FIG. 5 is a schematic diagram showing the operation of the blood purifier as a filter in the embodiment of the blood purification apparatus of the present invention.

FIG. 6 is a partial flowchart showing a filter as a blood purifier in an embodiment of a method of controlling replenishment liquid to a blood purification apparatus according to the present invention.

Fig. 7 is a schematic diagram of the operation of the blood purifier as a dialyzer in the embodiment of the blood purification apparatus of the present invention.

FIG. 8 is a partial flow chart of the embodiment of the method for controlling the replenishment solution in the blood purification apparatus of the present invention in which the blood purifier is a dialyzer.

The invention is further explained with reference to the drawings and the embodiments.

Detailed Description

The embodiment of the fluid infusion control method of the blood purification equipment comprises the following steps:

the fluid infusion control method of the blood purification device of the embodiment is applied to the blood purification device, referring to fig. 1, the blood purification device includes a host 1, a display screen 2, a first weighing scale 315 and other components, the display screen 2 is a human-computer interactive touch screen, a circuit board capable of achieving interactive communication with the display screen 2 is arranged in the host 1, a processor and a memory are arranged on the circuit board, the memory stores a computer program, and the computer program is executed by the processor to implement the steps of the fluid infusion control method of the blood purification device of the embodiment, so that the display screen 2 and the host 1 can achieve interactive communication, and a medical worker can input an instruction on the display screen 2 to enable the blood purification device to execute the steps of the fluid infusion control method of the blood purification device of the embodiment according to the operation requirement of the medical worker, so as to ensure the safety of blood purification treatment of a patient.

Referring to fig. 2, the extracorporeal blood purification circuit part of the blood purification apparatus comprises: the blood purification device comprises an artery clamp 31, a blood pump 32, a heparin pump 33 (namely an anticoagulation pump), a blood purifier 34, a venous pot 36, a liquid level detector 35, a bubble detector 37, a blood detector 38, a vein clamp 39, an artery pipeline 310, a vein pipeline 311, a fluid infusion branch 312, a switch assembly 316, a substitution liquid pump 313 and a fluid infusion bag 314, wherein the artery pipeline 310 outputs blood of a human body to the blood purifier 34, the blood pump 32 is adopted to provide driving force so that the blood circulates between the artery pipeline 310 and the vein pipeline 311, when the blood passes through the blood purifier 34, the blood purifier 34 can filter and purify specific molecular substances in the blood, and then the purified blood is returned to the human body through the vein pipeline 311 so as to achieve the purposes of purifying the blood and treating diseases. The fluid infusion branch 312 is communicated between the fluid infusion bag 314 and the arterial line 310 or the venous line 311, the substitution fluid pump 313 provides driving force to add the supplementary fluid in the fluid infusion bag 314 to the extracorporeal blood, a switch component 316 is arranged on the fluid infusion branch 312, the switch component 316 is used for controlling the connection or disconnection of the fluid infusion branch 312, when the switch component 316 is disconnected, the fluid infusion branch 312 is disconnected, the fluid in the fluid infusion branch 312 cannot flow, when the switch component 316 is connected, the fluid infusion branch 312 is connected, and the supplementary fluid in the fluid infusion bag 314 is output to the extracorporeal blood circuit through the fluid infusion branch 312. Be provided with heating device on the first weigh scale 315 of this embodiment, be used for placing fluid infusion bag 314 on the first weigh scale 315, and first weigh scale 315 is used for detecting the weight of fluid infusion bag 314, and heating device is used for heating fluid infusion bag 314. Preferably, the first weight scale 315 may be implemented by a load cell, and the heating component may be implemented by a heating resistance wire.

According to the clinical treatment requirement of the patient, the blood purification treatment process performs a fluid replacement operation, wherein the fluid replacement operation is to output the supplementary fluid in the fluid replacement bag 314 to an extracorporeal blood circuit, which is an arterial line 310 or a venous line 311, so as to achieve a better blood purification treatment effect. It should be noted that the fluid replacement operation is not an essential step in the blood purification treatment process, but is set according to the clinical treatment requirement of the patient, for example, when the patient needs to supplement nutrients in the blood purification treatment process, the fluid replacement operation is performed. In addition, in the fluid infusion operation, the fluid infusion branch 312 can output the fluid infusion to the arterial line 310 and the fluid infusion to the venous line 311, which are determined according to the blood purification treatment mode of the blood purification apparatus.

Wherein, the blood purification equipment can select different blood purification treatment modes according to the clinical treatment requirements of patients, such as: a slow continuous ultrafiltration treatment mode, a hemodiafiltration treatment mode, a hemodialysis treatment mode, a hemoperfusion treatment mode and the like, and under the selected blood purification treatment mode, the blood purification treatment function can be realized by using the blood purification equipment. When the blood purification apparatus is in different blood purification treatment modes, the types of the blood purifiers 34 will be different, for example, in the slow continuous ultrafiltration treatment mode, the blood purifiers 34 are filters, and in the hemodialysis treatment mode, the blood purifiers 34 are dialyzers, etc. The extracorporeal blood circuit components of the blood purification apparatus may also be changed when the blood purification apparatus is in different blood purification treatment modes, wherein fig. 2 shows a most basic structural schematic of the extracorporeal blood circuit of the blood purification apparatus, and the extracorporeal blood circuit of the blood purification apparatus may be modified or deformed based on fig. 2 when the blood purification apparatus is in different blood purification treatment modes.

Referring to fig. 3, fig. 3 is a flowchart of the fluid replacement control method of the blood purification apparatus of the present embodiment, and the specific implementation steps of the fluid replacement control method of the blood purification apparatus of the present embodiment are as follows.

Step S1, controlling the blood purifier to perform blood purification operation, namely after the blood purification equipment is started and started, and after a user selects a blood purification treatment mode, accessing the blood purifier into the blood of a human body in the selected blood purification treatment mode, and purifying the blood through the blood purifier so as to perform the blood purification operation of the blood purifier.

Step S2, obtaining a first weight W1 of the fluid infusion bag 314 detected by the first weighing scale 315, specifically, the fluid infusion bag 314 stores a certain volume of the fluid infusion solution in advance, for example, the total volume of the fluid infusion bag 314 is: 1000g, then, 1000g of the replenishing liquid is stored in the replenishing bag 314 in advance in the initial state, the replenishing liquid is continuously output to the extracorporeal blood circuit by the replenishing bag 314 during the blood purification treatment, the weight of the replenishing bag 314 is reduced, the first weight W1 of the replenishing bag 314 is detected in real time by the first weighing scale 315, and the blood purification treatment state can be reflected according to the first weight W1 of the replenishing bag 314.

S3, determining whether the first weight W1 is larger than a first preset weight, if so, executing the step S4; if not, step S5 is executed.

And S4, after the first weight W1 is determined to be larger than the first preset weight in the step S3, controlling the heating device to start heating the fluid infusion bag 314 in the step S4, and simultaneously carrying out feedback adjustment on the heating power of the heating device according to the first weight W1, wherein the heating power and the first weight W1 are in direct proportion for feedback adjustment.

And S5, after the first weight W1 is determined to be less than or equal to the first preset weight in the step S3, controlling the heating device to be closed and stop heating in the step S5.

Specifically, the first preset weight represents a limit of whether the fluid infusion bag 314 stores a sufficient amount of the supplementary fluid, and if the first weight W1 of the fluid infusion bag 314 is greater than the first preset weight, it indicates that the fluid infusion bag 314 stores a sufficient amount of the supplementary fluid, and the fluid infusion bag 314 can output the supplementary fluid to the extracorporeal blood circuit; if the first weight W1 of fluid replacement bag 314 is less than or equal to the first predetermined weight, indicating that the fluid replacement bag 314 is storing insufficient amount of fluid replacement, fluid replacement bag 314 is unable to deliver fluid replacement to the extracorporeal blood circuit, which is often the case when the fluid replacement operation of fluid replacement bag 314 has been completed and the user forgets to turn off first weigh scale 315. The first preset weight is determined according to the total volume of the fluid replenishing bag 314, for example, the maximum weight of the fluid replenishing bag 314 capable of storing the fluid replenishing liquid is 2000g, the first preset weight is 10% of the maximum weight of the fluid replenishing liquid plus the weight of the fluid replenishing bag 314 itself, for example, the weight of the fluid replenishing bag 314 itself is 200g, and then the first preset weight = (2000X 10% + 200) g =400g. Only when the first weight W1 of the fluid infusion bag 314 is greater than the first preset weight, the heating device will heat the fluid infusion bag 314, so as to prevent the heating device from heating the empty bag of the fluid infusion bag 314 and damaging the safety of the fluid infusion bag 314.

Meanwhile, the heating power of the heating device is feedback-regulated according to the first weight W1 of the fluid infusion bag 314, and the heating temperature of the heating device can be changed by regulating the heating power of the heating device, for example, when the heating power of the heating device is 500W, the heating temperature of the heating device is 35 ℃, and when the heating power of the heating device is regulated to 1000W, the heating temperature of the heating device is regulated to 37 ℃. In step S5, feedback adjustment is performed on the heating power of the heating device according to the first weight W1 of the fluid infusion bag 314, so that the heating temperature of the heating device and the first weight W1 of the fluid infusion bag 314 can be in a stable relationship, for example, if the temperature of the supplementary fluid in the fluid infusion bag 314 needs to be maintained at 36 ℃, and if the first weight W1 of the fluid infusion bag 314 is 1500g, the heating temperature of the heating device needs to be 37 ℃, the heating power of the heating device is adjusted to 1000W; when the first weight W1 of the fluid infusion bag 314 is 500g, the heating temperature of the heating device is required to be 35 ℃, the heating power of the heating device is adjusted to 500W, and feedback adjustment is performed according to the direct proportion relationship between the heating power and the first weight W1. Therefore, the fluid infusion control method of the blood purification apparatus of the embodiment can adaptively adjust the heating power of the heating device according to the first weight W1 of the fluid infusion bag 314, so that the temperature of the supplementing fluid in the heated fluid infusion bag 314 is always maintained in a stable state, and the heating stability of the supplementing fluid in the fluid infusion bag 314 is improved.

Optionally, a PID (Proportional integral derivative) feedback adjustment is performed on the heating power of the heating device according to the first weight W1 of the fluid infusion bag 314, and a PID control algorithm belongs to a conventional feedback adjustment method, which has high control response accuracy.

And S6, acquiring a fluid replacement operation instruction, which indicates that the blood purification equipment needs to perform fluid replacement operation.

In step S7, a first temperature T1 of the replenishment liquid in the replenishment liquid bag 314 is detected, and a second temperature T2 of the blood in the extracorporeal blood circuit of the blood purifier is detected.

S8, judging whether | T1-T2| ≦ Δ T1, if yes, executing S9; if not, step S10 is executed. Wherein Δ T1 is a first predetermined temperature difference.

And S9, outputting the supplementary liquid into the extracorporeal blood circuit.

And S10, controlling the blood purification equipment to send out an acousto-optic alarm signal.

Specifically, when the blood purification apparatus recognizes and acquires the fluid replacement operation instruction output by the user, it indicates that the blood purification apparatus needs to perform the fluid replacement operation. When the condition that the absolute value of T1-T2 is less than or equal to delta T1 is met, the temperature of the supplementary liquid meets the human physiological temperature safety standard, and the supplementary liquid can be output to an extracorporeal blood circuit to finish the liquid supplementing operation. When the condition that the absolute value of T1-T2 is less than or equal to delta T1 is not satisfied, the temperature of the supplementary liquid is not in accordance with the human physiological temperature safety standard, the supplementary liquid cannot be output to an extracorporeal blood loop, and the blood purification equipment is controlled to send out an acousto-optic alarm signal which is used for giving a prompt to a user according to the acousto-optic alarm signal: the replenishment solution has a temperature failure.

In the condition that the temperature of the blood is less than or equal to the temperature of the blood in the | T1-T2|, the temperature of the blood is used as a judgment standard to judge whether the temperature of the supplementary liquid in the supplementary liquid bag 314 has a temperature fault, only when the temperature of the heated supplementary liquid and the temperature of the blood are equal or approximately equal (the condition that the temperature of the | T1-T2| is less than or equal to the temperature of the blood is met), the temperature of the blood cannot be increased or decreased violently after the supplementary liquid is added, the purified blood can be returned to the human body, and the safety of the blood purification treatment of the patient is guaranteed. On the contrary, when the temperature of the heated supplementary liquid and the temperature of the blood have large deviation (the condition of | T1-T2| ≦ Δ T1 is not satisfied), the temperature of the blood is increased or decreased sharply after the supplementary liquid is added, and the safety of the blood purification treatment of the patient is damaged. Therefore, the fluid replacement control method of the blood purification device of the embodiment can accurately judge whether the temperature of the fluid replacement meets the human physiological temperature safety standard.

It should be noted that the first preset temperature difference is set by the user in advance, and the first preset temperature difference represents a temperature error allowed by the user, for example, the first preset temperature difference is 1 ℃, and when the temperature of the supplementary liquid is 35 ℃, the temperature of the blood is 36 ℃, |35 ℃ -36 | =1 ≦ 1 ℃, then the condition of | T1-T2| ≦ Δ T1 is satisfied, and the supplementary liquid may be output to the extracorporeal blood circuit.

Optionally, the second temperature T2 of the blood in the extracorporeal blood circuit refers to the temperature of the blood in the arterial line or the temperature of the blood in the venous line, preferably the second temperature T2 of the blood in the extracorporeal blood circuit is the temperature of the blood in the arterial line.

And S11, detecting the real-time flow of the blood in the extracorporeal blood circuit, and performing feedback regulation on the fluid infusion flow Q1 of the supplementing fluid according to the real-time flow, wherein the fluid infusion flow Q1 and the real-time flow are in a direct proportion relation for feedback regulation.

Specifically, both the real-time flow rate of blood in the extracorporeal blood circuit and the replacement flow rate Q1 of the replacement fluid need to maintain a stable relationship, and when the real-time flow rate of blood in the extracorporeal blood circuit becomes larger, the replacement flow rate Q1 of the replacement fluid output by the replacement fluid bag 314 also needs to become larger, so that the purified blood can be safely returned to the human body, thereby ensuring the safety of blood purification treatment of the patient. The fluid infusion control method of the blood purification apparatus of the embodiment can perform feedback adjustment on the fluid infusion flow Q1 of the supplementary fluid through the real-time flow of the blood in the extracorporeal blood circuit, so that the fluid infusion flow Q1 of the supplementary fluid output by the fluid infusion bag 314 and the real-time flow of the blood in the extracorporeal blood circuit keep a stable matching relationship, and the safety of blood purification treatment is improved.

It should be noted that, a corresponding curve between the real-time flow rate of blood in the extracorporeal blood circuit and the replacement flow rate Q1 of the replacement fluid output by the replacement fluid bag 314 is set according to the clinical technical experience of the user, and as shown in fig. 4, when the real-time flow rate of blood in the extracorporeal blood circuit is obtained, the corresponding replacement flow rate Q1 of the replacement fluid can be obtained according to the corresponding curve in fig. 4, so as to complete the feedback adjustment of the replacement flow rate Q1 of the replacement fluid output by the replacement fluid bag 314. Therefore, when the real-time flow rate of blood in the extracorporeal blood circuit changes, the fluid infusion flow rate Q1 of the supplement fluid output by the fluid infusion bag 314 also changes, and the fluid infusion flow rate Q1 of the supplement fluid subjected to feedback adjustment and the real-time flow rate of blood in the extracorporeal blood circuit always keep a stable matching relationship, so that the blood purification treatment efficiency of the patient is higher.

Step S12, calculating and obtaining the residual transfusion time of the fluid infusion bag 314

And controls the display screen 2 of the blood purification apparatus to display the remaining transfusion time t. Where Δ W is the bag weight of the fluid infusion bag 314.

Specifically, how long time is left to replace the fluid infusion bag 314 can be obtained according to the remaining infusion time t of the fluid infusion bag 314, so that the user can conveniently and safely control the fluid infusion operation of the blood purification device. Such as: the first weight W1 of the fluid infusion bag 314 is 1000g, the fluid infusion flow Q1 of the supplement fluid output by the fluid infusion bag 314 is 10g/min, the bag weight of the fluid infusion bag 314 is 100g, the remaining infusion time t = (1000 g-100 g)/10 g/min =90min for the fluid infusion bag 314, the fluid infusion bag 314 needs 90min to output all the supplement fluid, a user can know the actual condition of the supplement fluid output by the fluid infusion bag 314 in time, and the blood purification treatment process has higher fluid infusion control efficiency.

Step S13, judging whether the residual transfusion time t is less than a first preset time, if so, executing step S14; if not, step S12 is executed.

In step S14, the control switch assembly 316 closes the fluid infusion branch, so that the fluid infusion branch stops outputting the supplementary fluid.

If the remaining infusion time t is greater than or equal to the first preset time, the control switch assembly 316 is turned on, so that the fluid infusion branch outputs the fluid infusion. Specifically, the first preset time is used for judging whether the supplementary liquid in the liquid replenishing bag 314 can be continuously output, and when the remaining transfusion time t of the liquid replenishing bag 314 is less than the first preset time, it indicates that the supplementary liquid in the liquid replenishing bag 314 cannot be continuously output; when the remaining infusion time t of the fluid infusion bag 314 is greater than or equal to the first preset time, it indicates that the supplementary fluid in the fluid infusion bag 314 can be continuously output. According to the fluid infusion control method of the blood purification device, whether the fluid infusion bag 314 meets the safe output condition of the fluid infusion can be judged by comparing the residual infusion time t of the fluid infusion bag 314 with the first preset time, so that the continuity and the safety of the fluid infusion operation are greatly guaranteed.

Illustratively, the first preset time is 30S; if the remaining infusion time t of the fluid infusion bag 314 is less than 30S, the control switch component 316 closes the fluid infusion branch, so that the fluid infusion branch stops outputting the supplementary fluid (if the fluid infusion branch continues to output the supplementary fluid in this case, this may cause an empty bag phenomenon in the fluid infusion bag 314, and a user may not guarantee continuity of the fluid infusion operation in a bag replacement operation for the fluid infusion bag 314, and may also damage physical safety of the fluid infusion branch). If the remaining infusion time t of the fluid infusion bag 314 is greater than or equal to 30S, the control switch assembly 316 is turned on, so that the fluid infusion branch continues to output the fluid infusion, and the fluid infusion operation can be performed normally.

And step S15, detecting the real-time conductivity of the replenishing liquid.

Step S16, detecting whether the real-time conductivity of the replenishing liquid exceeds a preset conductivity, if so, executing step S17; if not, step S15 is executed.

And S17, controlling the blood purification equipment to send out a fault alarm signal.

Specifically, the real-time conductivity of the supplementary liquid represents the ion concentration of the supplementary liquid, wherein the supplementary liquid contains sodium ions, potassium ions and the like, and the ion concentration in the supplementary liquid influences the conductivity of the supplementary liquid, so that the ion concentration in the supplementary liquid can be directly deduced according to the real-time conductivity of the supplementary liquid. When the detected real-time conductivity exceeds the preset conductivity, indicating that the supplementary liquid does not accord with the ion concentration quality standard, controlling the blood purification equipment to send out a fault alarm signal to prompt a user: the ion concentration in the supplementary liquid is in a fault state, a user can timely handle the ion concentration fault of the supplementary liquid, for example, the real-time conductivity of the supplementary liquid is 15mS/cm, the concentration of sodium ions in the supplementary liquid is calculated to be 100mmol/L, if the normal concentration range of the sodium ions in the supplementary liquid is 110 mmol/L-120 mmol/L, the concentration of the sodium ions in the supplementary liquid is out of the normal concentration range, the concentration of the sodium ions in the supplementary liquid is judged to be out of the normal concentration range, and a fault alarm signal is sent out to play a fault prompt function. Therefore, the fluid replacement control method of the blood purification device can accurately judge whether the real-time conductivity of the fluid replacement exceeds the preset conductivity, and ensures the safety of fluid replacement operation in the blood purification treatment process.

It should be noted that, the real-time conductivity of the replenishment liquid may be detected by the conductivity sensor, and the concentration of the ions in the replenishment liquid may be directly obtained according to the preset corresponding relationship when the real-time conductivity of the replenishment liquid is obtained according to the corresponding relationship between the real-time conductivity of the replenishment liquid and the concentration of the ions in the solution (the corresponding relationship is preset).

Step S18, judging whether the first temperature T1 of the supplementing liquid in the supplementing bag 314 is greater than a preset warning temperature T, if so, executing step S19; if not, step S7 is executed.

And a step S19, when the first temperature T1 of the replenishing liquid in the replenishing liquid bag 314 is judged to be higher than the preset warning temperature T in the step S18, the step S19 controls the blood purifying device to stop the blood purifying operation.

When the blood purifier 34 of the blood purification apparatus of the present embodiment is the filter 341, the replenishment control method of the blood purification apparatus of the present embodiment further includes executing steps S20 to S32. In the case where the blood purifier 34 is the filter 341, when the filter 341 is connected to blood, the filter 341 filters specific substances such as inflammatory factors in the blood and generates waste liquid, a waste liquid output line 342 is further provided on the filter 341, the waste liquid output line 342 of the filter 341 is configured to output the waste liquid, a waste liquid pump 343 is provided on the waste liquid output line 342, the waste liquid pump 343 provides power for discharging the waste liquid from the waste liquid output line 342, an output end of the waste liquid output line 342 is connected to a waste liquid bag 344, the waste liquid bag 344 is placed on a second scale 345 of the blood purification apparatus, the second scale 345 is configured to detect a weight of the waste liquid bag 344, and the waste liquid bag 344 is communicated with a waste liquid output end of the filter 341 through the waste liquid output line 342 and is configured to collect the waste liquid, as shown in fig. 5.

Referring to fig. 6, fig. 6 is a partial flowchart of the blood purifier filter 341 in the fluid replacement control method of the blood purification apparatus according to the present embodiment, and steps S20 to S32 are specifically as follows.

In step S20, a third temperature T3 of the waste liquid is detected.

Step S21, judging whether | T1-T3| < delta T2 is satisfied, if yes, executing step S20; if not, step S22 is executed. Wherein Δ T2 is a second predetermined temperature difference.

In step S22, the blood purification apparatus is controlled to send a failure signal to the filter 341.

Specifically, the waste liquid in the waste liquid bag 344 is a pathogenic factor removed from the blood of the human body, so that the supplementary liquid is the liquid added to the blood of the human body and the waste liquid is the liquid removed from the blood of the human body when the blood purification treatment process is in a normal state, and only when the first temperature T1 of the supplementary liquid and the third temperature T3 of the waste liquid are kept close (that is, the condition of | T1-T3| ≦ Δ T2 is satisfied), the temperature of the blood in the extracorporeal blood circuit does not change dramatically, so that the temperature of the blood in the extracorporeal blood circuit is in a stable state, and further, the temperature of the blood in the blood purification treatment process is in a safe state.

If the first temperature T1 of the supplemental fluid and the third temperature T3 of the waste fluid are very different (i.e. the condition of | T1-T3| ≦ Δ T2 is not satisfied), this may cause a drastic change in the temperature of the blood in the extracorporeal blood circuit, thereby compromising the safety of the blood purification treatment for the patient, for example, if the first temperature T1 of the supplemental fluid is 37 ℃, the third temperature T3 of the waste fluid is 34 ℃, and the second preset temperature difference Δ T2 is 2 ℃, then |37 ℃ -34 | =3 ℃ > 2 ℃, the condition of | T1-T3| ≦ Δ T2 is not satisfied, which indicates that the first temperature T1 of the supplemental fluid added to the blood is far greater than the third temperature T3 of the waste fluid removed from the blood, which may cause a drastic increase in the temperature of the blood in the extracorporeal blood circuit, causing the patient to experience discomfort during the blood purification treatment; for the same reason, for example, the first temperature T1 of the replenishment liquid is: 34 ℃, the third temperature T3 of the waste fluid is 37 ℃, the second preset temperature difference Δ T2 is 2 ℃, then |34 ℃ to 37 | =3 ℃ is greater than 2 ℃, the condition of | T1-T3| ≦ Δ T2 is not satisfied, which indicates that the first temperature T1 of the supplement fluid added to the blood is much lower than the third temperature T3 of the waste fluid removed from the blood, and the heat of the blood in the extracorporeal blood circuit is lost too much, which may cause the temperature of the blood in the extracorporeal blood circuit to drop sharply, causing the patient to have uncomfortable symptoms during the blood purification treatment.

The second preset temperature difference value delta T2 is set by a user in advance, and the second preset temperature difference value delta T2 is related to the external environment temperature, the blood purification treatment duration and other factors.

Therefore, the fluid replacement control method of the blood purification apparatus of the present embodiment can determine whether the temperature of the blood in the extracorporeal blood circuit has failed according to the difference between the first temperature T1 of the fluid replacement and the third temperature T3 of the waste fluid, so that the temperature of the blood in the extracorporeal blood circuit can be always in a stable state.

In step S23, a second weight W2 of the waste liquid bag 344 detected by the second weigh scale 345 is acquired.

In step S24, the weight increasing rate ρ 1 of the waste liquid bag 344 is calculated and obtained from the second weight W2, and the weight decreasing rate ρ 2 of the fluid infusion bag 314 is calculated and obtained from the first weight W1.

Step S25, judging whether | rho 1-rho 2| ≧ Δ rho is satisfied, if yes, executing step S26; if not, go to step S24. Where Δ ρ is a preset weight change rate.

In step S26, it is determined that the liquid in the filter 341 is in an unbalanced state.

When the blood purifier is the filter 341, the filter 341 purifies blood, the supplementary liquid in the substitution bag 314 is output to the blood in the extracorporeal blood circuit, the filter 341 removes a pathogenic factor in the blood of a human body, and the waste liquid output end of the filter 341 outputs waste liquid, and when the blood purification treatment process is in a normal state, both the waste liquid filtered from the blood and the supplementary liquid added to the blood need to be balanced, so the substitution control method of the blood purification apparatus of the present embodiment can determine whether the filter 341 is in a liquid balanced state according to the difference between the weight reduction rate ρ 2 of the substitution bag 314 and the weight increase rate ρ 1 of the waste liquid bag 344. Illustratively, when | ρ 1- ρ 2| ≧ Δ ρ is unsatisfied, the filter 341 is determined to be in a liquid equilibrium state; when | ρ 1- ρ 2| ≧ Δ ρ, it is determined that the filter 341 is not in a liquid equilibrium state, that is, the liquid in the filter 341 is in an unbalanced state.

For example, the weight reduction rate ρ 2 of the fluid infusion bag 314 is 10g/min, the weight increase rate ρ 1 of the waste fluid bag 344 is 12g/min, the predetermined weight change rate Δ ρ is 1g/min, |10g/min to 12g/min | =2g/min > 1g/min, which indicates that the waste fluid output from the filter 341 is too fast, and after a long time of blood purification treatment, it is likely that the patient may have symptoms such as dehydration, and it is determined that the fluid in the filter 341 is in an unbalanced state. For another example, the weight reduction rate ρ 2 of the fluid infusion bag 314 is 10g/min, the weight increase rate ρ 1 of the waste fluid bag 344 is 10.5g/min, the preset weight change rate Δ ρ is 1g/min, |10g/min-10.5g/min | =0.5g/min < 1g/min, which indicates that the filter 341 is in a liquid equilibrium state.

The fluid replacement control method of the blood purification apparatus of the present embodiment determines whether the filter 341 is in a fluid equilibrium state by calculating the weight reduction rate ρ 2 of the fluid replacement bag 314 and the weight increase rate ρ 1 of the waste fluid bag 344, thereby ensuring the safety of the blood purification treatment of the patient.

Step S27, determining whether the weight increase rate ρ 1 of the waste liquid bag 344 is greater than a preset increase rate, if yes, executing step S28; if not, go to step S24.

And step S28, controlling the blood purification equipment to send out a purification fault alarm signal.

Specifically, when the filter 341 purifies blood, the weight increase rate ρ 1 of the waste liquid bag 344 can represent the blood purification efficiency of the filter 341, where the blood purification efficiency of the filter 341 refers to a rate at which the filter 341 removes a pathogenic factor from blood per unit time, for example, 5g of the pathogenic factor from blood is removed by the filter 341 in 1 min. When the filter 341 removes the blood-causing agent at a higher rate, the larger the weight increase rate ρ 1 of the waste liquid bag 344, the higher the blood purification efficiency of the filter 341. When the blood purification treatment process of the patient is in a normal state, the blood purification efficiency of the filter 341 also needs to be in a normal range, the blood purification efficiency cannot be too fast, once the blood purification efficiency of the filter 341 is too fast, the control difficulty of the blood purification equipment is increased, the rate of substances lost in the blood of the human body is too fast, a lot of beneficial substances are easily lost in the blood of the human body, and therefore the blood purification efficiency of the filter 341 is not suitable to be too fast. For example, in a normal case, the preset increase rate is 12g/min, and if the weight increase rate ρ 1 of the waste liquid bag 344 is 13g/min and 13g/min > 12g/min, it is determined that the blood purification efficiency of the filter 341 is too high and the safety of the blood purification treatment of the patient is seriously damaged, and the blood purification apparatus is controlled to send a purification failure alarm signal to prompt the user of the occurrence of the blood purification failure. Therefore, the fluid replacement control method of the blood purification apparatus of the present embodiment can accurately determine whether the blood purification efficiency of the filter 341 is too high based on the weight increase rate ρ 1 of the waste fluid bag 344, and promptly remove the failure state during the blood purification process.

And S29, calculating and acquiring the temperature change rate of the waste liquid according to the third temperature T3.

Step S30, judging whether the temperature change rate is smaller than a preset safe change rate, if so, executing step S31; if not, step S20 is executed.

And step S31, controlling the heating device to be closed and stopping heating.

If the temperature change rate of the waste liquid is smaller than the preset safe change rate, the fact that the liquid supplementing bag 314 needs to stop heating is judged; if the temperature change rate of the waste liquid is greater than or equal to the preset safe change rate, it is determined that the fluid infusion bag 314 does not need to be stopped, i.e., the heating device continuously heats the fluid infusion bag 314. The preset safety change rate is a preset value, and can be set according to the technical experience of technicians.

There are two main factors for influencing the temperature of the replenishment liquid in the replenishment liquid bag 314: the initial temperature of the replenishing liquid in the replenishing bag 314 and the external temperature during the blood purification treatment. In order to keep the replenishing liquid in the fluid infusion bag 314 from deteriorating, the storage temperature of the replenishing liquid is generally 5-10 ℃, so that during the fluid infusion operation, the heating device needs to be controlled to heat the fluid infusion bag 314 so as to heat the replenishing liquid in the fluid infusion bag 314 to heat the first temperature T1 of the replenishing liquid to be close to the second temperature T2 of the blood in the extracorporeal blood circuit. Since the temperature of the supplementary fluid in the fluid infusion bag 314 decreases due to heat loss when the external temperature is low (e.g., in winter) during the blood purification treatment, the first temperature T1 of the supplementary fluid in the fluid infusion bag 314 is maintained in a stable state by continuously heating the supplementary fluid in the fluid infusion bag 314 by the heating device. However, when the external temperature is high (e.g., in summer), the first temperature T1 of the supplement liquid in the fluid infusion bag 314 does not drop very quickly, and at this time, when the first temperature T1 of the supplement liquid and the second temperature T2 of the blood in the extracorporeal blood circuit satisfy the condition of | T1-T2| ≦ Δ T1, if it is determined that the temperature change rate of the waste fluid is less than the preset safe change rate, which indicates that the external temperature is originally very high, the fluid infusion bag 314 does not need to be heated, so that the heating device is controlled to be turned off to stop heating. The fluid infusion control method of the blood purification apparatus of this embodiment judges whether the external temperature is high according to the temperature change rate of the waste fluid, for example, when the temperature change rate of the waste fluid is smaller than the preset safe change rate, it indicates that the external temperature is high, and then the fluid infusion bag 314 does not need to be heated continuously, and the temperature of the fluid infusion in the fluid infusion bag 314 can be maintained in a stable state automatically, so as to reduce the power loss generated by the heating device and save the heating cost of the blood purification apparatus.

Illustratively, the preset safety change rate is 3 ℃/h, if the calculated temperature change rate of the waste liquid is 2 ℃/h (the temperature of the waste liquid is reduced by 2 ℃ in 1 hour), and the temperature is less than 3 ℃/h, the external temperature is judged to be high, and the liquid supplementing bag 314 needs to stop heating; if the temperature change rate of the waste liquid obtained by calculation is 4 ℃/h, and 4 ℃/h is more than 3 ℃/h, the external temperature is judged to be low, the external temperature can enable the temperature of the supplementary liquid in the liquid supplementing bag 314 to be rapidly reduced, and the heating device needs to be controlled to continuously heat the supplementary liquid in the liquid supplementing bag 314, so that the temperature of the supplementary liquid in the liquid supplementing bag 314 can meet the safety standard of the physiological temperature of the human body, and the heating efficiency of the supplementary liquid and the safety of blood purification treatment are improved.

It should be noted that, in this embodiment, whether the external temperature belongs to the high temperature is determined according to the temperature change rate of the waste liquid, and whether the external temperature belongs to the high temperature is determined without adopting the temperature change rate of the replenishment liquid, because the replenishment liquid bag 314 is always in the heating state, the temperature change rate of the replenishment liquid cannot truly reflect the real change situation of the external temperature, and the waste liquid in the waste liquid bag 344 does not need to be heated, the real change situation of the external temperature can be truly and accurately reflected according to the temperature change rate of the waste liquid, and then the external temperature is determined to be the high temperature or the low temperature, so that the accuracy of the temperature determination is ensured.

Step S32, the preset alert temperature T = T3+ (5 ℃ -6 ℃) is reset.

Specifically, the preset alarm temperature T represents the highest safe temperature of the supplementary liquid in the fluid infusion bag 314, for example, the preset alarm temperature T of the fluid infusion bag 314 is 39 ℃, and when the first temperature T1 of the supplementary liquid in the fluid infusion bag 314 is greater than 39 ℃, it indicates that the temperature of the supplementary liquid is too high, and the blood purification device needs to be controlled to stop the blood purification operation, so as to prevent the temperature of the blood in the extracorporeal blood circuit from being too high.

The fluid infusion control method of the blood purification apparatus of this embodiment resets the preset warning temperature T of the fluid infusion bag 314 according to the third temperature T3 of the waste fluid, wherein the third temperature T3 of the waste fluid in the waste fluid bag 344 represents the heat lost in the blood, and the supplementary fluid in the fluid infusion bag 314 is output to the blood circuit, so as to compensate for the heat lost by the waste fluid in the extracorporeal blood circuit due to the discharge of the waste fluid, the preset warning temperature T = T3+ (5 ℃ -6 ℃) is reset, so that the first temperature T1 of the supplementary fluid in the fluid infusion bag 314 can meet the safety standard of the physiological temperature of the human body, and the first temperature T1 of the supplementary fluid cannot be too high or too low, and thus the preset warning temperature T can be reset scientifically and reasonably.

In this embodiment, the preset alert temperature T = T3+ (5-6 ℃), for example, the third temperature T3 of the waste liquid is 33 ℃, the preset alert temperature T =33 ℃ + (5-6 ℃) = (38-39 ℃), for example, the preset alert temperature T is 39 ℃, when the first temperature T1 of the supplementary liquid in the liquid supplementing bag 314 is detected to be greater than 39 ℃, it indicates that the temperature of the supplementary liquid in the liquid supplementing bag 314 is too high, and the filter 341 needs to be controlled to stop purifying, so as to ensure the safety of the blood purification treatment of the patient.

It should be noted that, in steps S18 and S19, "when the first temperature T1 is determined to be greater than the preset alert temperature T, the blood purification apparatus is controlled to stop the blood purification operation", and in steps S8 and S9, "when it is determined that | T1-T2| ≦ Δ T1 is satisfied, the supplementary liquid is outputted into the extracorporeal blood circuit", these two determination steps do not have correlation, where steps S18 and S19 are to determine whether the heated supplementary liquid exceeds the preset alert temperature T, and steps S8 and S9 are to determine whether the heated supplementary liquid matches the temperature of the blood in the extracorporeal blood circuit, for example, the preset alert temperature T is 38 ℃, the first temperature T1 of the supplementary liquid in the supplementary liquid bag 314 is 39 ℃, the second temperature T2 of the blood in the extracorporeal blood circuit is 37 ℃, and the first preset temperature difference Δ T1 is 2 ℃; the condition of | T1-T2| < Δ T1 is satisfied, but the first temperature T1 of the supplementary liquid in the supplementary liquid bag 314 is greater than the preset warning temperature T, so whether the first temperature T1 of the supplementary liquid in the supplementary liquid is in a safe state is respectively judged from two dimensions.

When the blood purifier 34 of the blood purification apparatus of the present embodiment is the dialyzer 346, the fluid replacement control method of the blood purification apparatus of the present embodiment further includes executing steps S33 to S44. When the blood purifier 34 is a dialyzer 346, a dialysate is input to a dialysate input end of the dialyzer 346, and a dialysate output end of the dialyzer 346 outputs a recovery liquid. The blood purification apparatus of the present embodiment further comprises a third weight scale 350 and a fourth weight scale 354, the third weight scale 350 is used for placing a dialysate bag 349, the third weight scale 350 is used for detecting the weight of the dialysate bag 349, the dialysate bag 349 is communicated with the dialysate input end of the dialyzer 346 through a dialysis branch 347 and is used for supplying dialysate, the dialysis branch 347 is provided with a dialysate pump 348, and a driving force is provided when supplying dialysate. Be used for placing stock solution bag 353 on the fourth weighing scale 354, and fourth weighing scale 354 is used for detecting the weight of stock solution bag 353, and stock solution bag 353 is linked together and is used for collecting the recovery liquid through waste liquid branch 351 and the dislysate output of cerini dialyser cerini 346, is provided with waste liquid pump 352 on the waste liquid branch 351, provides drive power when collecting the recovery liquid, as shown in fig. 7. Wherein, a dialysate bag 349 prestores a certain volume of dialysate, such as 3000g dialysate, a dialysate input end of a dialyzer 346 is connected with the dialysate, a blood input end of the dialyzer 346 is connected with the blood, a hollow fiber membrane exists inside the dialyzer 346, the blood and the dialysate are respectively positioned at two sides of the hollow fiber membrane, a large amount of water and middle and small molecular toxins in a patient body are removed through principles of dispersion, convection, ultrafiltration and the like under the action of osmotic pressure and transmembrane pressure, the balance of water, electrolyte and alkaline acid in the body is maintained, then a recovered liquid (waste liquid) is output to the liquid storage bag 353 through a dialysate output end of the dialyzer 346, the liquid storage bag 353 is used for storing the waste liquid, and a blood output end of the dialysate outputs purified blood to complete a hemodialysis treatment process.

Referring to fig. 8, fig. 8 is a partial flowchart of the method for controlling the replenishment solution of the blood purification apparatus according to the present embodiment, where the blood purifier is the dialyzer 346, and steps S33 to S44 are specifically as follows.

In step S33, the first liquid flow rate Q2 of the dialysate is detected, and the second liquid flow rate Q3 of the collected liquid is detected.

Step S34, judging whether | Q2-Q3| ≧ Δ Q is satisfied, if yes, executing step S35; if not, go to step S36. Wherein Δ Q is a predetermined liquid flow rate

Step S35, the blood purification apparatus is controlled to send a dialyzer 346 fluid imbalance fault signal.

Specifically, during the hemodialysis treatment of the patient, the dialysate enters the dialyzer 346 and diffuses, convects and ultrafiltrates with the blood, the first flow rate Q2 of the dialysate and the second flow rate Q3 of the recovery fluid should be kept approximately balanced, so as not to cause the body fluid imbalance of the patient, and then whether the purification process of the dialyzer 346 is faulty or not can be determined according to the difference between the first flow rate Q2 of the dialysate and the second flow rate Q3 of the recovery fluid. For example, when | Q2-Q3| < Δ Q, it indicates that the first fluid flow Q2 of the dialysate and the second fluid flow Q3 of the recovery fluid are substantially equal, and the blood after hemodialysis is in a fluid balance state, and it is determined that the purification process of the dialyzer 346 has not failed; when | Q2-Q3| ≧ Δ Q, it means that the error between the first fluid flow rate Q2 of the dialysate and the second fluid flow rate Q3 of the recovery liquid is large, the patient is in a fluid imbalance state during hemodialysis, the patient can have a fluid imbalance, and the purification process of the dialyzer 346 has a fault.

The fluid infusion control method of the blood purification device of the embodiment can judge whether the body fluid imbalance phenomenon occurs to the patient in the hemodialysis treatment process according to the difference value between the first fluid flow Q2 of the dialysate and the second fluid flow Q3 of the recovery fluid, so that the safety of the patient in the hemodialysis treatment is guaranteed.

In step S36, a fourth temperature T4 of the dialysate is detected, and a fifth temperature T5 of the recovery fluid is detected.

Step S37, judging whether | T4-T5| ≦ Δ T3, if yes, executing step S36; if not, go to step S38. Wherein, delta T3 is a third preset temperature difference value

In step S38, it is judged that the dialyzer 346 has a dialysis temperature failure.

In step S39, the preset guard temperature T = T5+2 × (T4-T5) is reset.

When the liquid imbalance phenomenon of the blood in the dialyzer 346 is judged to be absent, namely | Q2-Q3| < Δ Q, whether the temperature fault occurs in the blood purification treatment process is judged by | T4-T5| < Δ T3. Specifically, | T4-T5| represents the difference in temperature of the fluid in the dialyzer 346 caused by the dialysate passing through the dialyzer 346, and typically, for example, the fourth temperature T4 of the dialysate is 36 ℃, the fifth temperature T5 of the recovery fluid is 34 ℃, and | T4-T5| =2 ℃, which means that the temperature of the dialysate decreases by 2 ℃ after the dialysate passes through the dialyzer 346. The temperature drop of the blood caused by the blood passing through the dialyzer 346 can be estimated according to the temperature difference between the fourth temperature T4 of the dialysate and the fifth temperature T5 of the recovery fluid, the preset warning temperature T can be reset according to the temperature difference between the fourth temperature T4 of the dialysate and the fifth temperature T5 of the recovery fluid, and whether the first temperature T1 of the heated supplementary fluid in the supplementary fluid bag 314 is too high can be determined according to the preset warning temperature T. When the first temperature T1 of the supplementary liquid in the liquid supplementing bag 314 is judged to be greater than the preset warning temperature T, it is indicated that the first temperature T1 of the heated supplementary liquid in the liquid supplementing bag 314 is too high, and the blood purifier stops purifying, so as to ensure the safety of the blood purification treatment of the patient.

Illustratively, the fourth temperature T4 of the dialysate is 36 ℃, the fifth temperature T5 of the recovery fluid is 34 ℃,36 ℃ -34 ℃ =2 ℃, and the reset preset guard temperature T =34 ℃ +2X (36 ℃ -34 ℃) =38 ℃. When the first temperature T1 of the heated supplementary liquid in the liquid replenishing bag 314 is greater than the preset warning temperature T, it indicates that the temperature of the heated supplementary liquid in the liquid replenishing bag 314 is too high.

According to the fluid infusion control method of the blood purification equipment, whether the condition that | T4-T5| is less than or equal to Δ T3 is met or not is judged, if not, the condition that the temperature of the liquid is rapidly reduced when the dialysate flows through the dialyzer 346 is explained, and the occurrence of the dialysis temperature fault of the dialyzer 346 is judged (the reason for the dialysis temperature fault is that the liquid inside the dialyzer 346 is blocked and the liquid cannot flow inside the dialyzer 346 generally), so that the fluid infusion control method of the blood purification equipment can also judge whether the dialysis temperature fault occurs in the dialysate inside the dialyzer 346 or not, and the safety of hemodialysis of a patient is comprehensively guaranteed.

Step S40, obtaining a third weight W3 of the dialysate bag 349 detected by the third weight scale 350, and calculating a weight reduction rate ρ 3 of the dialysate bag 349 according to the third weight W3; the fourth weight W4 of the reservoir 353 detected by the fourth weight scale 354 is acquired, and the weight increase rate ρ 4 of the reservoir 353 is calculated and acquired from the fourth weight W4.

In step S41, when the weight increase rate ρ 4 of the reservoir 353 is greater than the weight decrease rate ρ 3 of the dialysate bag 349, step S42 is performed.

And step S42, increasing the preset warning temperature t on the basis of resetting.

In step S43, when the weight increase rate ρ 4 of the reservoir bag 353 is smaller than the weight decrease rate ρ 3 of the dialysate bag 349, step S44 is performed.

And step S44, reducing the preset warning temperature t on the basis of resetting.

Specifically, the rate of weight increase ρ 4 of the reservoir bag 353 may be increased, decreased, or equal to the rate of weight decrease ρ 3 of the dialysate bag 349 after diffusion, convection, ultrafiltration, and the like of the blood and dialysate within the dialyzer 346. When the preset warning temperature T is reset in step S39, the temperature determination error caused by the liquid loss or the liquid increase in the dialyzer 346 is not considered, so the fluid replacement control method of the blood purification apparatus of this embodiment further calibrates the preset warning temperature T according to the comparison between the weight reduction rate ρ 3 of the dialysate bag 349 and the weight increase rate ρ 4 of the liquid bag 353, and the calibrated preset warning temperature T has accuracy to determine whether the first temperature T1 of the supplementary fluid in the fluid replacement bag 314 is too high, thereby reducing the temperature determination error.

Illustratively, when the weight increase rate ρ 4 of the reservoir 353 is greater than the weight decrease rate ρ 3 of the dialysate bag 349, it indicates that a part of substances are absorbed by the blood in the dialyzer 346, which may cause a decrease in the temperature of the blood output from the blood output end of the dialyzer 346, and the preset alarm temperature T needs to be increased on the basis of the reset value, so that the first temperature T1 of the supplementary fluid in the fluid supply bag 314 can be increased as much as possible, and when the supplementary fluid is output to the extracorporeal blood circuit, the temperature of the purified blood can just reach the normal temperature. For example, in step S39, the preset guard temperature t is set to 38 ℃ and the calibrated preset guard temperature t is set to 39 ℃ when the weight increase rate ρ 4 of the reservoir bag 353 is greater than the weight decrease rate ρ 3 of the dialysate bag 349.

When the weight increase rate ρ 4 of the reservoir bag 353 is smaller than the weight decrease rate ρ 3 of the dialysate bag 349, it indicates that part of substances in the blood in the dialyzer 346 are filtered, which may cause the temperature of the blood output from the blood output end of the dialyzer 346 to rise, and the preset alarm temperature T needs to be reduced on the basis of resetting, so that the first temperature T1 of the supplementary fluid in the fluid replenishing bag 314 may not rise too high, and the temperature of the purified blood is prevented from exceeding the normal temperature. For example, in step S39, the preset guard temperature t is set to 38 ℃ and the calibrated preset guard temperature t is set to 37 ℃ when the weight increase rate ρ 4 of the reservoir bag 353 is smaller than the weight decrease rate ρ 3 of the dialysate bag 349.

It should be noted that the preset warning temperature t is increased or decreased on the basis of the resetting, wherein the increase or decrease of the preset warning temperature t is related to the difference between the weight decrease rate ρ 3 of the dialysate bag 349 and the weight decrease rate ρ 3 of the dialysate bag 349, and when the difference is larger, the increase or decrease of the preset warning temperature t is larger; the magnitude of increase or decrease of the preset guard temperature t is smaller as the difference is smaller. The increase or decrease of the preset alarm temperature t has a numerical correspondence with the difference between the weight reduction rate ρ 3 of the dialysate bag 349 and the weight reduction rate ρ 3 of the dialysate bag 349, which can be preset according to experience of clinical technicians.

Therefore, after the fluid infusion control method of the blood purification apparatus of this embodiment recalibrates the preset warning temperature T, an error caused by the substance loss of the blood in the dialyzer 346 or the judgment of the first temperature T1 of the supplementary fluid in the fluid infusion bag 314 due to the addition can be eliminated, the judgment precision of the first temperature T1 of the supplementary fluid in the fluid infusion bag 314 is improved, and the safety of the hemodialysis treatment performed by the patient is ensured.

Blood purification apparatus embodiment:

the blood purification device comprises a host machine 1, a display screen 2 and other components, wherein the display screen 2 is a human-computer interactive touch screen, a circuit board which can realize interactive communication with the display screen 2 is arranged in the host machine 1, a processor and a memory are arranged on the circuit board, a computer program is stored in the memory, and each step of the fluid infusion control method of the blood purification device is realized when the computer program is executed by the processor.

For example, a computer program may be partitioned into one or more modules that are stored in a memory and executed by a processor to implement the modules of the present invention. One or more of the modules may be a series of computer program instruction segments capable of performing certain functions, which are used to describe the execution of the computer program in the terminal device.

The processor may be a Central Processing Unit (CPU), or may be other general-purpose processor, a Digital Signal Processor (DSP), an Application Specific Integrated Circuit (ASIC), an off-the-shelf Programmable Gate Array (FPGA) or other Programmable logic device, a discrete Gate or transistor logic device, a discrete hardware component, or the like. The general purpose processor may be a microprocessor or the processor may be any conventional processor or the like, the processor being the control center of the appliance and connected to the various parts of the overall appliance by various interfaces and lines.

The memory may be used to store computer programs and/or modules, and the processor may implement various functions of the appliance by operating or executing the computer programs and/or modules stored in the memory and calling data stored in the memory. The memory may mainly include a storage program area and a storage data area, wherein the storage program area may store an operating system, an application program required for at least one function, and the like; the storage data area may store data created according to use of the appliance, and the like. In addition, the memory may include high speed random access memory, and may also include non-volatile memory, such as a hard disk, a memory, a plug-in hard disk, a Smart Media Card (SMC), a Secure Digital (SD) Card, a Flash memory Card (Flash Card), at least one magnetic disk storage device, a Flash memory device, or other volatile solid state storage device.

Computer-readable storage medium embodiments:

the computer program stored in the memory of the blood purification apparatus may be stored in a computer-readable storage medium if it is implemented in the form of a software functional unit and sold or used as a separate product. Based on such understanding, all or part of the processes of the methods of the embodiments of the present invention may be implemented by a computer program, which may be stored in a computer readable storage medium, and when the computer program is executed by a processor, the computer program may implement the steps of the fluid replacement control method of the blood purification apparatus.

Wherein the computer program comprises computer program code, which may be in the form of source code, object code, an executable file or some intermediate form, etc. The computer readable medium may include: any entity or device capable of carrying computer program code, recording medium, U.S. disk, removable hard disk, magnetic disk, optical disk, computer Memory, read-Only Memory (ROM), random Access Memory (RAM), electrical carrier wave signals, telecommunications signals, software distribution media, and the like. It should be noted that the computer readable medium may contain other components which may be suitably increased or decreased as required by legislation and patent practice in jurisdictions, for example, in some jurisdictions, in accordance with legislation and patent practice, the computer readable medium does not include electrical carrier signals and telecommunications signals.

The above embodiments are only preferred examples of the present invention, and should not be construed as limiting the scope of the invention, so that the equivalent changes or modifications made by the structure, characteristics and principle of the claimed invention should be included in the scope of the invention.

Claims

1. The fluid infusion control method of the blood purification equipment is characterized in that a heating device is arranged on a first weighing scale of the blood purification equipment, a fluid infusion bag is placed on the first weighing scale, the first weighing scale is used for detecting the weight of the fluid infusion bag, the heating device is used for heating the fluid infusion bag, and the fluid infusion control method of the blood purification equipment comprises the following steps:

controlling the blood purifier to perform a blood purification operation;

acquiring a first weight W1 of the fluid infusion bag detected by the first weighing scale;

if the first weight W1 is determined to be larger than a first preset weight, controlling the heating device to start heating the fluid infusion bag, and simultaneously carrying out feedback regulation on the heating power of the heating device according to the first weight W1, wherein the heating power and the first weight W1 are in a direct proportion relationship for carrying out feedback regulation;

when a fluid replacement operation instruction is obtained, detecting a first temperature T1 of a replacement fluid in the fluid replacement bag, and detecting a second temperature T2 of blood in an extracorporeal blood circuit of the blood purifier;

and judging whether the absolute value of T1-T2 is less than or equal to delta T1, if so, outputting the supplementary liquid into the extracorporeal blood circuit, wherein delta T1 is a first preset temperature difference value.

2. The fluid replacement control method of a blood purification apparatus according to claim 1, characterized in that:

and when the first temperature T1 is judged to be higher than the preset warning temperature T, controlling the blood purification equipment to stop the blood purification operation.

3. The fluid replacement control method of a blood purification apparatus according to claim 2, characterized in that:

the blood purifier of the blood purification equipment is a filter, a waste liquid output end of the filter outputs waste liquid, and the liquid supplementing control method of the blood purification equipment further comprises the following steps:

detecting a third temperature T3 of the waste liquid;

judging whether the absolute value of T1-T3 is less than or equal to delta T2, if not, controlling the blood purification equipment to send out a filter fault signal;

wherein Δ T2 is a second predetermined temperature difference.

4. The fluid replacement control method of a blood purification apparatus according to claim 3, characterized in that:

the blood purification equipment further comprises a second weighing scale, wherein the second weighing scale is used for placing a waste liquid bag and detecting the weight of the waste liquid bag, and the waste liquid bag is communicated with the waste liquid output end of the filter and is used for collecting the waste liquid;

the fluid replacement control method of the blood purification apparatus further includes:

acquiring a second weight W2 of the waste liquid bag detected by the second weighing scale;

calculating and acquiring the weight increasing rate rho 1 of the waste liquid bag according to the second weight W2, and calculating and acquiring the weight decreasing rate rho 2 of the fluid infusion bag according to the first weight W1;

judging whether | rho 1-rho 2| ≧ Δ rho is satisfied, and if so, judging that the liquid of the filter is in an unbalanced state;

where Δ ρ is a preset weight change rate.

5. The fluid replacement control method of a blood purification apparatus according to claim 2, characterized in that:

the blood purifier of the blood purification equipment is a dialyzer, dialysate is input to a dialysate input end of the dialyzer, and recovery liquid is output to a dialysate output end of the dialyzer, and the fluid infusion control method of the blood purification equipment further comprises the following steps:

detecting a first liquid flow rate Q2 of the dialysate and a second liquid flow rate Q3 of the recovery liquid;

judging whether | Q2-Q3| ≧ Δ Q, if yes, controlling the blood purification equipment to send a dialyzer liquid imbalance fault signal;

wherein Δ Q is a preset liquid flow rate.

6. The fluid replacement control method of a blood purification apparatus according to claim 5, characterized in that:

judging whether | Q2-Q3| ≧ Δ Q, if not, the fluid infusion control method of the blood purification device further comprises:

detecting a fourth temperature T4 of the dialysate and detecting a fifth temperature T5 of the recovery fluid;

judging whether absolute T4-T5 is less than or equal to delta T3, and if not, judging that the dialyzer has dialysis temperature fault;

wherein Δ T3 is a third predetermined temperature difference.

7. The fluid replacement control method of a blood purification apparatus according to claim 6, characterized in that:

resetting the preset alert temperature T = T5+2 × (T4-T5).

8. The fluid replacement control method of a blood purification apparatus according to claim 7, characterized in that:

the blood purification equipment further comprises a third weighing scale and a fourth weighing scale, wherein the third weighing scale is used for placing a dialysate bag and detecting the weight of the dialysate bag, the dialysate bag is communicated with a dialysate input end of the dialyzer and is used for supplying dialysate, the fourth weighing scale is used for placing a liquid storage bag and detecting the weight of the liquid storage bag, and the liquid storage bag is communicated with a dialysate output end of the dialyzer and is used for collecting the recovery liquid;

acquiring a third weight W3 of the dialysate bag detected by the third weight scale, and calculating and acquiring a weight reduction rate ρ 3 of the dialysate bag according to the third weight W3;

acquiring a fourth weight W4 of the liquid storage bag detected by the fourth weighing scale, and calculating and acquiring a weight increase rate rho 4 of the liquid storage bag according to the fourth weight W4;

when the weight increase rate rho 4 of the liquid storage bag is greater than the weight decrease rate rho 3 of the dialysate bag, increasing the preset warning temperature t on the basis of resetting;

or when the weight increase rate ρ 4 of the liquid storage bag is smaller than the weight decrease rate ρ 3 of the dialysate bag, the preset warning temperature t is decreased on the basis of resetting.

9. Blood purification equipment, characterized by, including host computer and display screen, be provided with the circuit board that can realize interactive communication with the display screen in the host computer, be provided with treater and memory on the circuit board, the memory stores computer program, computer program realizes each step of the fluid replacement control method of blood purification equipment of any one of above-mentioned claim 1 to 8 when being executed by the treater.

10. A computer-readable storage medium having stored thereon a computer program, characterized in that:

the computer program, when executed by a processor, implements the steps of the fluid replacement control method for a blood purification apparatus according to any one of claims 1 to 8.