CN115381489A - Method and device for measuring ultrasonic blood flow parameters and ocular vascular indexes - Google Patents

Method and device for measuring ultrasonic blood flow parameters and ocular vascular indexes Download PDF

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CN115381489A
CN115381489A CN202110567200.5A CN202110567200A CN115381489A CN 115381489 A CN115381489 A CN 115381489A CN 202110567200 A CN202110567200 A CN 202110567200A CN 115381489 A CN115381489 A CN 115381489A
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杜宜纲
黄永
林穆清
杨雪梅
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Abstract

一种超声血流参数、眼部血管指数的测量方法及装置,该方法包括:获取目标血管的超声图像上的第一感兴趣位置和第二感兴趣位置;确定第一感兴趣位置和第二感兴趣位置之间的连线,其中连线包括划分的多个区间;针对每个区间,获取区间的两端位置处的向量血流速度以及区间的区间长度,并基于向量血流速度和区间长度计算区间的两端位置之间的血压差;基于每个区间的两端位置之间的血压差的大小在连线的不同区间上显示相应的颜色,以呈现第一感兴趣位置和第二感兴趣位置之间的血压差的变化趋势。本申请能够实现精确的局部压差计算。

Figure 202110567200

A method and device for measuring ultrasonic blood flow parameters and ocular vascular index, the method comprising: acquiring a first position of interest and a second position of interest on an ultrasonic image of a target blood vessel; determining the first position of interest and the second position of interest A connection line between positions of interest, wherein the connection line includes a plurality of divided intervals; for each interval, the vector blood flow velocity at the two ends of the interval and the interval length of the interval are obtained, and based on the vector blood flow velocity and the interval The length calculates the blood pressure difference between the two ends of the interval; based on the size of the blood pressure difference between the two ends of each interval, the corresponding color is displayed on different intervals of the connection line to present the first interest position and the second Trend of blood pressure difference between locations of interest. The application enables accurate calculation of local differential pressure.

Figure 202110567200

Description

超声血流参数、眼部血管指数的测量方法及装置Method and device for measuring ultrasonic blood flow parameters and ocular vascular index

技术领域technical field

本申请涉及超声扫描技术领域,更具体地涉及一种基于超声血流参数、眼部血管指数的测量方法及装置。The present application relates to the technical field of ultrasonic scanning, and more particularly relates to a method and device for measuring blood flow parameters and ocular vascular index based on ultrasonic waves.

背景技术Background technique

心脏瓣膜(包括主动脉瓣、三尖瓣、二尖瓣、肺动脉瓣等)异常时,通过瓣膜后局部血压会有异常的下降;动脉狭窄会造成血流通过狭窄处时局部血压的明显下降;颈动脉窦和主动脉弓的压力感受器出现问题时可能会引起高血压;静脉瓣异常反流时局部血压变化异常,使血液回流并可能产生血栓;眼压升高过多属于比较严重的眼部疾病,研究显示视网膜动脉硬化与血压和眼压都存在一定关系。When the heart valves (including aortic valve, tricuspid valve, mitral valve, pulmonary valve, etc.) are abnormal, there will be an abnormal drop in local blood pressure after passing through the valve; arterial stenosis will cause a significant drop in local blood pressure when the blood flow passes through the stenosis; Problems with the baroreceptors of the carotid sinus and aortic arch may cause high blood pressure; when the venous valve is abnormally regurgitated, the local blood pressure changes abnormally, causing blood to flow back and may cause thrombus; excessively elevated intraocular pressure is a relatively serious eye disease. Studies have shown that there is a certain relationship between retinal arteriosclerosis and blood pressure and intraocular pressure.

由此可见,局部血压变化的测量对于很多疾病的诊断和研究都有一定临床价值。穿刺针可以测量血管内压力,但是这是有创的。常见的无创方法主要有基于磁共振成像(MRI)或连续多普勒(CW)的血管内压差测量方法。但MRI检查时间长、成本高,CW缺失具体的测量位置信息。因此,为了使局部血压的精确测量在临床检查中普及起来,还需要更高级的超声测量方法和技术。It can be seen that the measurement of local blood pressure changes has certain clinical value for the diagnosis and research of many diseases. A needle can measure the pressure inside the blood vessel, but this is invasive. Common non-invasive methods mainly include intravascular pressure difference measurement methods based on magnetic resonance imaging (MRI) or continuous Doppler (CW). However, MRI examination takes a long time and costs high, and CW lacks specific measurement location information. Therefore, in order to popularize accurate measurement of regional blood pressure in clinical examination, more advanced ultrasonic measurement methods and techniques are needed.

发明内容Contents of the invention

根据本申请一方面,提供了一种超声血流参数的测量方法,所述方法包括:获取目标血管的超声图像上的第一感兴趣位置和所述第二感兴趣位置;确定所述第一感兴趣位置和所述第二感兴趣位置之间的连线,其中所述连线包括划分的多个区间;针对每个所述区间,获取所述区间的两端位置处的向量血流速度以及所述区间的区间长度,并基于所述向量血流速度和所述区间长度计算所述区间的两端位置之间的血压差;基于每个所述区间的两端位置之间的血压差的大小在所述连线的不同区间上显示相应的颜色,以呈现所述第一感兴趣位置和所述第二感兴趣位置之间的血压差的变化趋势。According to one aspect of the present application, a method for measuring ultrasonic blood flow parameters is provided, the method comprising: acquiring a first position of interest and the second position of interest on an ultrasonic image of a target blood vessel; determining the first position of interest A connection line between the location of interest and the second location of interest, wherein the connection line includes a plurality of divided intervals; for each of the intervals, obtain the vector blood flow velocity at the two ends of the interval and the interval length of the interval, and calculate the blood pressure difference between the two ends of the interval based on the vector blood flow velocity and the interval length; based on the blood pressure difference between the two ends of each interval Corresponding colors are displayed on different intervals of the connecting line, so as to present the variation trend of the blood pressure difference between the first location of interest and the second location of interest.

根据本申请另一方面,提供了一种超声血流参数的测量方法,所述方法包括:获取用户在目标血管的超声图像上描绘的连线,其中所述连线包括划分的多个区间;针对每个所述区间,获取所述区间的两端位置处的向量血流速度以及所述区间的区间长度,并基于所述向量血流速度和所述区间长度计算所述区间的两端位置之间的血压差;基于每个所述区间的两端位置之间的血压差的大小在所述连线的不同区间上显示相应的颜色,以呈现所述连线上的血压差的变化趋势。According to another aspect of the present application, a method for measuring ultrasonic blood flow parameters is provided, the method comprising: acquiring a connection line drawn by a user on an ultrasound image of a target blood vessel, wherein the connection line includes a plurality of divided intervals; For each interval, obtain the vector blood flow velocity at the two ends of the interval and the interval length of the interval, and calculate the two end positions of the interval based on the vector blood flow velocity and the interval length Based on the blood pressure difference between the two ends of each of the intervals, corresponding colors are displayed on different intervals of the line to present the change trend of the blood pressure difference on the line .

根据本申请再一方面,提供了一种超声血流参数的测量方法,所述方法包括:沿至少两个不同的扫描角度向目标血管发射超声波,接收所述超声波的回波,并基于所述超声波的回波获得至少两组超声回波信号,其中每组超声回波信号源自一个扫描角度发射的超声波;获取所述目标血管的超声图像上的第一感兴趣位置和第二感兴趣位置,以及所述第一感兴趣位置和所述第二感兴趣位置之间的长度;基于所述至少两组超声回波信号分别得到所述第一感兴趣位置处的至少两个速度分量和所述第二感兴趣位置的至少两个速度分量,并将每个所述感兴趣位置处的至少两个速度分量合成得到每个所述感兴趣位置处的向量血流速度,其中每个速度分量源自一组超声回波信号;基于所述第一感兴趣位置处的向量血流速度、所述第二感兴趣位置处的向量血流速度以及所述第一感兴趣位置和所述第二感兴趣位置之间的长度计算所述第一感兴趣位置与所述第二感兴趣位置之间的血压差。According to still another aspect of the present application, a method for measuring ultrasonic blood flow parameters is provided, the method comprising: transmitting ultrasonic waves to the target blood vessel along at least two different scanning angles, receiving the echoes of the ultrasonic waves, and based on the Obtaining at least two groups of ultrasonic echo signals, wherein each group of ultrasonic echo signals originates from ultrasonic waves emitted at a scanning angle; obtaining a first position of interest and a second position of interest on the ultrasonic image of the target blood vessel , and the length between the first position of interest and the second position of interest; based on the at least two groups of ultrasonic echo signals, at least two velocity components at the first position of interest and the at least two velocity components at the second position of interest, and synthesize at least two velocity components at each position of interest to obtain a vector blood flow velocity at each position of interest, wherein each velocity component derived from a set of ultrasound echo signals; based on the vector blood flow velocity at the first location of interest, the vector blood flow velocity at the second location of interest, and the first location of interest and the second The length between locations of interest calculates a blood pressure difference between the first location of interest and the second location of interest.

根据本申请再一方面,提供了一种眼部血管指数的测量方法,所述方法包括:获取目标血管的超声图像上的第一感兴趣位置与第二感兴趣位置之间的血压差,其中,所述第一感兴趣位置和第二感兴趣位置分别位于颈总动脉内和颈内动脉内;获取与所述颈内动脉连通的眼部血管的血流参数,所述血流参数包括收缩期峰值流速和舒张末期流速;计算所述收缩期峰值流速与舒张末期流速之间的速度差值,并计算和输出所述血压差与所述速度差值的比值。According to yet another aspect of the present application, a method for measuring an ocular vascular index is provided, the method comprising: acquiring a blood pressure difference between a first position of interest and a second position of interest on an ultrasound image of a target vessel, wherein , the first position of interest and the second position of interest are respectively located in the common carotid artery and the internal carotid artery; the blood flow parameters of the ocular blood vessels communicating with the internal carotid artery are obtained, and the blood flow parameters include contraction Phase peak flow velocity and end-diastole flow velocity; calculate the velocity difference between the systolic peak flow velocity and the end-diastole flow velocity, and calculate and output the ratio of the blood pressure difference to the velocity difference.

根据本申请又一方面,提供了一种超声血流成像装置,所述超声血流成像装置包括发射电路、接收电路、超声探头、处理器和显示器,其中:所述发射电路用于控制所述超声探头向目标对象的目标部位发射超声波;所述接收电路用于控制所述超声探头接收所述超声波的回波,并从所述超声波的回波获取超声回波信号;所述处理器用于基于所述超声回波信号进行超声血流成像;所述处理器还用于执行上述超声血流参数的测量方法;所述显示器用于显示所述处理器输出的结果。According to still another aspect of the present application, an ultrasonic blood flow imaging device is provided, the ultrasonic blood flow imaging device includes a transmitting circuit, a receiving circuit, an ultrasonic probe, a processor and a display, wherein: the transmitting circuit is used to control the The ultrasonic probe transmits ultrasonic waves to the target part of the target object; the receiving circuit is used to control the ultrasonic probe to receive the echoes of the ultrasonic waves, and obtain ultrasonic echo signals from the echoes of the ultrasonic waves; the processor is used to The ultrasonic echo signal is used for ultrasonic blood flow imaging; the processor is also used for executing the above method for measuring ultrasonic blood flow parameters; and the display is used for displaying the result output by the processor.

根据本申请实施例的超声血流参数、眼部血管指数的测量方法及装置能够实现精确的局部压差计算,且无创又快捷;此外,根据本申请实施例的超声血流参数的测量方法基于目标血管超声图像上两个感兴趣位置之间区域的多处向量血流速度生成两个感兴趣位置之间的压力梯度图,能够实现两个感兴趣位置之间的压差变化趋势的直观呈现,从而更好地辅助医生诊断;此外,眼部血管指数的测量方法基于颈动脉窦处的压降情况计算眼部供血情况相关的参数,能够为医生提供眼部疾病,尤其是缺血性眼部疾病的临床研究和相关指导。The method and device for measuring ultrasonic blood flow parameters and ocular vascular index according to the embodiments of the present application can realize accurate calculation of local pressure difference, and is non-invasive and fast; in addition, the measurement method of ultrasonic blood flow parameters according to the embodiments of the present application is based on Multiple vector blood flow velocities in the area between two positions of interest on the target blood vessel ultrasound image generate a pressure gradient map between the two positions of interest, which can realize the intuitive presentation of the trend of pressure difference between the two positions of interest , so as to better assist doctors in diagnosis; in addition, the measurement method of ocular vascular index calculates the parameters related to ocular blood supply based on the pressure drop at the carotid sinus, which can provide doctors with ocular diseases, especially ischemic ocular Clinical research and related guidance for certain diseases.

附图说明Description of drawings

通过结合附图对本申请实施例进行更详细的描述,本申请的上述以及其它目的、特征和优势将变得更加明显。附图用来提供对本申请实施例的进一步理解,并且构成说明书的一部分,与本申请实施例一起用于解释本申请,并不构成对本申请的限制。在附图中,相同的参考标号通常代表相同部件或步骤。The above and other objects, features and advantages of the present application will become more apparent through a more detailed description of the embodiments of the present application in conjunction with the accompanying drawings. The accompanying drawings are used to provide a further understanding of the embodiments of the present application, and constitute a part of the specification, and are used together with the embodiments of the present application to explain the present application, and do not constitute limitations to the present application. In the drawings, the same reference numerals generally represent the same components or steps.

图1示出根据本申请一个实施例的超声血流参数的测量方法的示意性流程图。Fig. 1 shows a schematic flowchart of a method for measuring ultrasonic blood flow parameters according to an embodiment of the present application.

图2示出根据本申请一个实施例的超声血流参数的测量方法中两个感兴趣位置以及它们之间的连线的示例性示意图。Fig. 2 shows an exemplary schematic diagram of two positions of interest and a connection line between them in the method for measuring ultrasonic blood flow parameters according to an embodiment of the present application.

图3示出根据本申请一个实施例的超声血流参数的测量方法中两个感兴趣位置以及它们之间的连线的示例性示意图。Fig. 3 shows an exemplary schematic diagram of two positions of interest and a connection line between them in the method for measuring ultrasonic blood flow parameters according to an embodiment of the present application.

图4示出根据本申请一个实施例的超声血流参数的测量方法中血压差的变化趋势的示例性示意图。Fig. 4 shows an exemplary schematic diagram of the variation trend of blood pressure difference in the method for measuring ultrasonic blood flow parameters according to an embodiment of the present application.

图5示出根据本申请另一个实施例的超声血流参数的测量方法的示意性流程图。Fig. 5 shows a schematic flowchart of a method for measuring ultrasonic blood flow parameters according to another embodiment of the present application.

图6示出根据本申请再一个实施例的超声血流参数的测量方法的示意性流程图。Fig. 6 shows a schematic flowchart of a method for measuring ultrasonic blood flow parameters according to yet another embodiment of the present application.

图7示出根据本申请再一个实施例的超声血流参数的测量方法中三个感兴趣位置以及它们之间的连线的示例性示意图。Fig. 7 shows an exemplary schematic diagram of three positions of interest and the lines between them in the method for measuring ultrasonic blood flow parameters according to yet another embodiment of the present application.

图8示出根据本申请又一个实施例的超声血流参数的测量方法的示意性流程图。Fig. 8 shows a schematic flowchart of a method for measuring ultrasonic blood flow parameters according to yet another embodiment of the present application.

图9示出根据本申请再一个实施例的眼部血管指数的测量方法的示意性流程图。Fig. 9 shows a schematic flowchart of a method for measuring an ocular vascular index according to yet another embodiment of the present application.

图10示出根据本申请再一个实施例的眼部血管指数的测量方法中两个感兴趣位置的示例性示意图。Fig. 10 shows an exemplary schematic diagram of two positions of interest in a method for measuring an ocular vascular index according to yet another embodiment of the present application.

图11示出根据本申请实施例的超声血流成像装置的示意性结构框图。Fig. 11 shows a schematic structural block diagram of an ultrasonic blood flow imaging device according to an embodiment of the present application.

具体实施方式Detailed ways

为了使得本申请的目的、技术方案和优点更为明显,下面将参照附图详细描述根据本申请的示例实施例。显然,所描述的实施例仅仅是本申请的一部分实施例,而不是本申请的全部实施例,应理解,本申请不受这里描述的示例实施例的限制。基于本申请中描述的本申请实施例,本领域技术人员在没有付出创造性劳动的情况下所得到的所有其它实施例都应落入本申请的保护范围之内。In order to make the objects, technical solutions, and advantages of the present application more apparent, exemplary embodiments according to the present application will be described in detail below with reference to the accompanying drawings. Apparently, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments of the present application. It should be understood that the present application is not limited by the exemplary embodiments described here. Based on the embodiments of the present application described in the present application, all other embodiments obtained by those skilled in the art without creative efforts shall fall within the protection scope of the present application.

首先,参照图1描述根据本申请一个实施例的超声血流参数的测量方法。图1示出了根据本申请一个实施例的超声血流参数的测量方法100的示意性流程图。如图1所示,基于超声血流参数的测量方法100可以包括如下步骤:First, a method for measuring ultrasonic blood flow parameters according to an embodiment of the present application will be described with reference to FIG. 1 . Fig. 1 shows a schematic flowchart of a method 100 for measuring ultrasonic blood flow parameters according to an embodiment of the present application. As shown in FIG. 1, a method 100 for measuring blood flow parameters based on ultrasound may include the following steps:

在步骤S110,获取目标血管的超声图像上的第一感兴趣位置和第二感兴趣位置。In step S110, a first position of interest and a second position of interest on the ultrasonic image of the target blood vessel are acquired.

在本申请的实施例中,可以首先对目标血管进行超声成像得到目标血管的超声图像,并将其显示给用户,由用户来通过该超声图像确定要进行压差测量的两个感兴趣位置(例如通过用户交互界面),即第一感兴趣位置和第二感兴趣位置。因此,根据用户操作,可获取用户选定的第一感兴趣位置和第二感兴趣位置。在其他示例中,也可以由超声系统在一些情况下自动选取两个感兴趣位置,例如系统通过检测发现血管某处可能存在问题,则可自动确定要测量血压差的位置。In the embodiment of the present application, the ultrasonic imaging of the target blood vessel can be performed first to obtain the ultrasonic image of the target blood vessel, which is displayed to the user, and the user can determine the two positions of interest ( For example, through a user interaction interface), that is, the first location of interest and the second location of interest. Therefore, according to the user's operation, the first location of interest and the second location of interest selected by the user can be obtained. In other examples, the ultrasound system can also automatically select two positions of interest in some cases. For example, the system can automatically determine the position where the blood pressure difference is to be measured if the system finds that there may be a problem somewhere in the blood vessel through detection.

图2和图3分别示出了血管内两个感兴趣位置的两个示例。其中,图2示出了分叉血管示意图,例如颈动脉分叉,在希望测量从颈总动脉至颈内动脉之间的血压差时,可以自动或者由用户手动确定两个感兴趣位置,如图2中所示的第一感兴趣位置A和第二感兴趣位置B。图3示出了有斑块的血管示意图,系统通过检测发现血管某处存在斑块时,可以自动确定斑块两侧的感兴趣位置,如图3中所示的第一感兴趣位置A和第二感兴趣位置B,以测量血流通过斑块后的压降。当然,图3中所示的两个感兴趣位置也可以是由用户来确定的。Figures 2 and 3 show two examples of two locations of interest within a blood vessel, respectively. Wherein, FIG. 2 shows a schematic diagram of a bifurcated blood vessel, such as a carotid artery bifurcation. When it is desired to measure the blood pressure difference from the common carotid artery to the internal carotid artery, two positions of interest can be determined automatically or manually by the user, such as A first location of interest A and a second location of interest B shown in FIG. 2 . Figure 3 shows a schematic diagram of a blood vessel with plaque. When the system detects that there is plaque somewhere in the blood vessel, it can automatically determine the positions of interest on both sides of the plaque, as shown in Figure 3. The first position of interest A and A second location of interest, B, to measure the pressure drop after blood flow through the plaque. Certainly, the two positions of interest shown in FIG. 3 may also be determined by the user.

在步骤S120,确定所述第一感兴趣位置和所述第二感兴趣位置之间的连线,其中所述连线包括划分的多个区间。In step S120, a connection line between the first location of interest and the second location of interest is determined, wherein the connection line includes a plurality of divided intervals.

在本申请的实施例中,在获取第一感兴趣位置和第二感兴趣位置之后,可以确定第一感兴趣位置和第二感兴趣位置之间的连线,其中,该连线为一段连续的且分别与第一感兴趣位置和第二感兴趣位置相接的连线,并且该连线被划分为多个区间。该连线可以是直线、折线、曲线或者不规则形状的线条,此处不做具体限制。该连线可以是线条型或带状,也就是说可以具有一定的厚度。在本申请的实施例中,将两个感兴趣位置之间的连线划分为多个区间是为了对每个区间进行血压差计算,以得到两个感兴趣位置之间的压差变化趋势,从而更精确地实现局部血压变化的测量,如下文的步骤S130到步骤S140将描述的。In the embodiment of the present application, after the first location of interest and the second location of interest are obtained, the connection between the first location of interest and the second location of interest can be determined, wherein the connection is a continuous The connecting lines connected to the first position of interest and the second position of interest respectively, and the connecting line is divided into a plurality of intervals. The connection line may be a straight line, a broken line, a curve or an irregularly shaped line, which is not specifically limited here. The connection line can be in the shape of a line or a strip, that is to say, it can have a certain thickness. In the embodiment of the present application, the purpose of dividing the line between two locations of interest into multiple intervals is to calculate the blood pressure difference for each interval, so as to obtain the change trend of the pressure difference between the two locations of interest, Thereby, the measurement of local blood pressure changes can be realized more accurately, as will be described in steps S130 to S140 below.

示例性地,第一感兴趣位置和第二感兴趣位置之间的连线(诸如如图2和图3所示的第一感兴趣位置A和第二感兴趣位置B之间的连线),该连线可被划分为多个线段以作为多个区间(诸如如图4所示的第一感兴趣位置A和第二感兴趣位置B之间的连线被划分为等距或者不等距的多段)。在一个示例中,可以根据第一感兴趣位置和第二感兴趣位置所在的血管的走势自动生成第一感兴趣位置和第二感兴趣位置之间的连线,使得该连线大致与血管的轴线保持一致。具体的,该连线上的点到血管前壁和后壁的距离大致相同,使得该连线大致处于血管的中间区域。血流大致是沿着血管的走势方向在流动,通过该方式能够描绘出大致的血流流动路径,特别是针对分叉处的血管,能够很好的呈现血流走势,通过计算连线上各区间的血压差,方便医生快速了解局部血管的血流状态。在另一个示例中,可以根据第一感兴趣位置和第二感兴趣位置所在的血管的血流流动路径生成第一感兴趣位置和第二感兴趣位置之间的连线,使得生成的该连线更贴近血流的真实流动路径。具体的,可以根据第一感兴趣位置和第二感兴趣位置所在的血管的向量血流速度确定血流流动路径,例如以血流流入位置(第一感兴趣位置或第二感兴趣位置)作为起始点,基于该起始点的向量血流速度的方向取相邻点,基于该相邻点的向量血流速度的方向继续找相邻点,最后将这些点拟合为上述连线。通过该方式能够准确的识别血流的真实流向,因此能够更准确的描绘出血流的流动路径,为后续进行血压差的测量提供更精准的定位,给医生判断局部血管的血流状态提供更准确的测量指标。在另一个示例中,可以由用户手动描绘例如通过用户交互界面在超声图像上描绘出第一感兴趣位置和第二感兴趣位置之间的连线。Exemplarily, the line between the first position of interest and the second position of interest (such as the line between the first position of interest A and the second position of interest B as shown in FIG. 2 and FIG. 3 ) , the line can be divided into multiple line segments as multiple intervals (such as the line between the first position of interest A and the second position of interest B as shown in Figure 4 is divided into equidistant or unequal multiple segments of the distance). In one example, the connection line between the first position of interest and the second position of interest can be automatically generated according to the trends of the blood vessels where the first position of interest and the second position of interest are located, so that the line is roughly in line with the Axes remain the same. Specifically, the distances from the points on the line to the front wall and the back wall of the blood vessel are approximately the same, so that the line is approximately in the middle area of the blood vessel. The blood flow roughly flows along the trend direction of the blood vessels. This method can describe the approximate blood flow path, especially for the blood vessels at the bifurcation, which can well present the blood flow trend. By calculating the The blood pressure difference between intervals is convenient for doctors to quickly understand the blood flow status of local blood vessels. In another example, the connection line between the first position of interest and the second position of interest may be generated according to the blood flow path of the vessel where the first position of interest and the second position of interest are located, so that the generated connection The line is closer to the real flow path of blood flow. Specifically, the blood flow path can be determined according to the vector blood flow velocity of the blood vessel where the first position of interest and the second position of interest are located, for example, the blood flow inflow position (the first position of interest or the second position of interest) is used as The starting point, based on the direction of the vector blood flow velocity of the starting point, select adjacent points, continue to find adjacent points based on the direction of the vector blood flow velocity of the adjacent point, and finally fit these points to the above-mentioned connection line. This method can accurately identify the real flow direction of blood flow, so it can more accurately describe the flow path of blood flow, provide more accurate positioning for subsequent measurement of blood pressure difference, and provide doctors with better judgment of blood flow status of local blood vessels. Accurate measurement indicators. In another example, the connecting line between the first location of interest and the second location of interest may be manually drawn by the user, for example, on the ultrasound image through a user interaction interface.

在步骤S130,针对每个所述区间,获取所述区间的两端位置处的向量血流速度以及所述区间的区间长度,并基于所述向量血流速度和所述区间长度计算所述区间的两端位置之间的血压差。In step S130, for each interval, the vector blood flow velocity at the two ends of the interval and the interval length of the interval are obtained, and the interval is calculated based on the vector blood flow velocity and the interval length The difference in blood pressure between the two ends of the position.

在本申请的实施例中,针对第一感兴趣位置和第二感兴趣位置之间的连线被划分的每个区间,可获取该区间的两端位置处的向量血流速度以及该区间的长度,以计算该区间的两端位置之间的血压差。对每个区间都执行这样的计算,可得到每个区间的两端位置之间的血压差,从而得到第一感兴趣位置和第二感兴趣位置之间的压差变化情况。例如,针对第一感兴趣位置和第二感兴趣位置之间的连线,可自动或者用户手动将其划分为多个线段,针对每个线段,计算该线段两端的端点之间的向量血流速度以及该线段的长度,以计算该线段两端的端点之间的血压差,从而得到第一感兴趣位置和第二感兴趣位置之间的压差变化情况。以图4所示示例来描述,第一感兴趣位置A和第二感兴趣位置B之间的压差变化情况可以通过如下公式(1)来计算:In the embodiment of the present application, for each interval divided by the connecting line between the first position of interest and the second position of interest, the vector blood flow velocity at the two ends of the interval and the length to calculate the difference in blood pressure between the two ends of the interval. Such calculation is performed for each interval, and the blood pressure difference between the two ends of each interval can be obtained, so as to obtain the change of the pressure difference between the first location of interest and the second location of interest. For example, for the connection line between the first position of interest and the second position of interest, it can be divided into multiple line segments automatically or manually by the user, and for each line segment, the vector blood flow between the endpoints at both ends of the line segment is calculated The speed and the length of the line segment are used to calculate the blood pressure difference between the two ends of the line segment, so as to obtain the change of the pressure difference between the first position of interest and the second position of interest. Taking the example shown in FIG. 4 as an example, the change in pressure difference between the first location of interest A and the second location of interest B can be calculated by the following formula (1):

Figure BDA0003081340280000071
Figure BDA0003081340280000071

其中,i和j为第一感兴趣位置A和第二感兴趣位置B之间的连线上任意一个区间的两个端点(例如第一感兴趣位置A和第二感兴趣位置B之间的连线上相邻两点的位置),Δpij为该区间两个端点i和j之间的血压差,vi和vj分别为该区间两个端点i和j处各自的向量血流速度,lij为该区间的长度,ρ是血液密度(血粘度),t是时间变量。基于公式(1)计算两个感兴趣位置之间的压差时,没有忽略血粘度的影响,没有忽略AB两点之间的速度变化,相对于后面实施例中描述的计算方式(诸如公式(3)和公式(5)),能够得到最精确的局部压差计算结果。而基于公式(1)计算两个感兴趣位置之间的压差时,需要两个感兴趣位置之间很多点的速度才能做积分,只有向量血流成像技术才能满足这种精确的压差计算方式。因此,根据本申请实施例的基于超声血流成像的测量方法100基于向量血流速度计算局部血管压差,能够实现精确的局部压差计算,且无创又快捷。Wherein, i and j are the two endpoints of any interval on the line between the first position of interest A and the second position of interest B (for example, the distance between the first position of interest A and the second position of interest B The positions of two adjacent points on the connecting line), Δp ij is the blood pressure difference between the two endpoints i and j of the interval, v i and v j are the respective vector blood flow velocities at the two endpoints i and j of the interval , l ij is the length of the interval, ρ is the blood density (blood viscosity), and t is the time variable. When calculating the pressure difference between two points of interest based on formula (1), the influence of blood viscosity and the speed change between the two points AB and AB are not ignored. Compared with the calculation method described in the following examples (such as the formula ( 3) and formula (5)), the most accurate calculation result of local pressure difference can be obtained. However, when calculating the pressure difference between two locations of interest based on formula (1), the velocity of many points between the two locations of interest is required to be integrated. Only vector flow imaging technology can satisfy this precise pressure difference calculation. Way. Therefore, the measurement method 100 based on ultrasonic blood flow imaging according to the embodiment of the present application calculates the local vascular pressure difference based on the vector blood flow velocity, which can realize accurate calculation of the local pressure difference, and is non-invasive and fast.

在本申请的实施例中,各区间的两端位置处的向量血流速度可以是通过斑点跟踪法、横向波振荡法或者基于多普勒原理的多角度偏转发射和/或接收方法计算得到的。该向量血流速度可包括速度大小,也可以包括速度大小和方向。In the embodiment of the present application, the vector blood flow velocity at the two ends of each interval can be calculated by the speckle tracking method, the transverse wave oscillation method or the multi-angle deflection transmission and/or reception method based on the Doppler principle . The vector blood flow velocity may include the magnitude of the velocity, and may also include the magnitude and direction of the velocity.

其中,以通过多角度偏转发射/接收方法得到向量血流速度为例,通过超声探头沿第一扫描角度向目标血流区域发射超声波,接收从该目标血流区域返回的该超声波的超声回波。基于超声回波,获得沿该第一扫描角度的第一超声回波信号,根据该第一超声回波信号,得到目标血流区域内目标位置(也可以叫目标点)的第一血流速度,该第一血流速度实际上是该目标位置的向量血流速度在该第一扫描角度上的投影分量(也可以称之为速度分量)。同样的,通过超声探头沿第二扫描角度向目标血流区域发射超声波,可得到该目标位置的第二血流速度,该第二血流速度实际上是该目标位置的向量血流速度在该第二扫描角度上的投影分量(也可以称之为速度分量)。对该第一血流速度和第二血流速度进行角度合成得到实际的速度大小和方向,即向量血流速度。Wherein, taking the vector blood flow velocity obtained by the multi-angle deflection transmission/reception method as an example, the ultrasonic probe is used to transmit ultrasonic waves to the target blood flow area along the first scanning angle, and receive the ultrasonic echo of the ultrasonic wave returned from the target blood flow area . Obtain a first ultrasonic echo signal along the first scanning angle based on the ultrasonic echo, and obtain a first blood flow velocity at a target position (also called a target point) in the target blood flow area according to the first ultrasonic echo signal , the first blood flow velocity is actually a projection component (also referred to as a velocity component) of the vector blood flow velocity at the target position on the first scanning angle. Similarly, the second blood flow velocity at the target position can be obtained by transmitting ultrasonic waves to the target blood flow region through the ultrasonic probe along the second scanning angle, and the second blood flow velocity is actually the vector blood flow velocity of the target position at the target position. The projected component on the second scan angle (also called the velocity component). Angle synthesis is performed on the first blood flow velocity and the second blood flow velocity to obtain the actual magnitude and direction of the velocity, that is, the vector blood flow velocity.

作为一例,还可以基于斑点跟踪的向量血流成像方法得到向量血流速度。其中可以采用绝对差值求和实现斑点跟踪的向量血流速度计算。其中,还可以基于平面波发射和斑点跟踪法,得到精度更高的向量血流速度。As an example, the vector blood flow velocity can also be obtained based on the vector blood flow imaging method of speckle tracking. The vector blood flow velocity calculation of spot tracking can be realized by using the absolute difference summation. Among them, the vector blood flow velocity with higher precision can also be obtained based on plane wave emission and speckle tracking method.

作为一例,还可以基于横向波振荡法的向量血流成像方法得到向量血流速度。其中,通过传统的基于多普勒原理的计算方法得到纵向速度,通过产生横向振荡的超声声场再基于自相关法计算得到横向速度,然后合并横纵向速度得到向量血流速度。As an example, the vector blood flow velocity can also be obtained by the vector blood flow imaging method based on the transverse wave oscillation method. Among them, the longitudinal velocity is obtained through the traditional calculation method based on the Doppler principle, the transverse velocity is calculated based on the autocorrelation method through the ultrasonic sound field that generates transverse oscillations, and then the vector blood flow velocity is obtained by combining the transverse and longitudinal velocities.

上述所说的向量血流速度,其速度大小为血流(如血流中的红细胞)的实际速度大小,或者说更接近血流(如血流中的红细胞)的实际速度大小;其速度方向为血流(如血流中的红细胞)的实际流动方向,或者说更接近血流(如血流中的红细胞)的实际流动方向;向量血流速度的方向可以在成像平面内的0°到360°的区间,其方向可表征血流的实际流动方向。The velocity of the above-mentioned vector blood flow is the actual velocity of the blood flow (such as the red blood cells in the blood flow), or is closer to the actual velocity of the blood flow (such as the red blood cells in the blood flow); its velocity direction is the actual flow direction of the blood flow (such as the red blood cells in the blood flow), or closer to the actual flow direction of the blood flow (such as the red blood cells in the blood flow); the direction of the vector blood flow velocity can be from 0° to In the interval of 360°, its direction can represent the actual flow direction of the blood flow.

基于各区间的两端位置处的向量血流速度,可以生成第一感兴趣位置和第二感兴趣位置之间的压力梯度图,以呈现第一感兴趣位置和第二感兴趣位置之间的血压差的变化趋势,如步骤S140将描述的。Based on the vector blood flow velocity at the two ends of each interval, a pressure gradient map between the first location of interest and the second location of interest can be generated to present the pressure gradient between the first location of interest and the second location of interest The variation trend of the blood pressure difference will be described in step S140.

在步骤S140,基于每个所述区间的两端位置之间的血压差的大小在所述连线的不同区间上显示相应的颜色,以呈现所述第一感兴趣位置和所述第二感兴趣位置之间的血压差的变化趋势。In step S140, based on the magnitude of the blood pressure difference between the positions at both ends of each of the intervals, corresponding colors are displayed on different intervals of the connecting line, so as to present the first interest location and the second sense of interest. Trends in blood pressure differences between locations of interest.

在本申请的实施例中,在计算得到第一感兴趣位置和第二感兴趣位置之间的连线的每个区间的两端位置之间的血压差后,可以在该连线的不同区间上以相应的颜色各区间的两端位置之间的血压差大小,以生成反映第一感兴趣位置和第二感兴趣位置之间的压降变化趋势的压力梯度图,例如如图4所示的。在图4中,以不同的颜色呈现不同区间不同的压降值。此处,应注意,受专利申请文件附图不能为彩色图的限制,图4中呈现的是灰度图,在实际应用中图4中的颜色图谱可以是彩色图谱,以更明显地体现两个感兴趣位置之间的压降趋势。在图4所示的示例中,是在第一感兴趣位置A和第二感兴趣位置B之间的连线的各个区间上以不同的颜色显示第一感兴趣位置A和第二感兴趣位置B之间的压差的变化趋势,这样的显示方式更能使得各区间的压降情况被明显地清晰地对应呈现。进一步的,当连线上某个区间的所述血压差的大小大于预设阈值时,提示某个区间对应的血流发生异常。例如,不同的颜色表征不同的压差大小,绿色表示该区间对应的血压差较小,血流流动比较顺畅,无明显的阻滞或斑块,红色表示该区间对应的血压差较大,该位置处可能存在斑块,医生通过颜色提示可以快速识别血管状态,准确定位异常位置,提高诊断效率。在其他示例中,也可以通过其他的方式来呈现两个感兴趣位置之间的压力梯度图,诸如以绘制反映不同区间不同压降的曲线图等线条形式。In the embodiment of the present application, after calculating the blood pressure difference between the two ends of each interval of the line between the first position of interest and the second position of interest, you can The blood pressure difference between the two ends of each interval is marked with the corresponding color to generate a pressure gradient map reflecting the pressure drop trend between the first position of interest and the second position of interest, for example, as shown in Figure 4 of. In Figure 4, different pressure drop values in different intervals are presented in different colors. Here, it should be noted that due to the restriction that the accompanying drawings of the patent application documents cannot be color images, what is presented in Figure 4 is a grayscale image. In practical applications, the color atlas in Figure 4 can be a color atlas to more clearly reflect the two Pressure drop trends between locations of interest. In the example shown in FIG. 4 , the first location of interest A and the second location of interest are displayed in different colors on each section of the connecting line between the first location of interest A and the second location of interest The change trend of the pressure difference between B, such a display method can make the pressure drop of each interval clearly and correspondingly presented. Further, when the blood pressure difference in a certain section on the line is greater than a preset threshold, it is indicated that the blood flow corresponding to a certain section is abnormal. For example, different colors represent different pressure differences. Green indicates that the blood pressure difference corresponding to this interval is small, the blood flow is relatively smooth, and there is no obvious block or plaque, and red indicates that the blood pressure difference corresponding to this interval is relatively large. There may be plaque at the location, and doctors can quickly identify the status of blood vessels through color prompts, accurately locate abnormal locations, and improve diagnostic efficiency. In other examples, the pressure gradient map between the two locations of interest may also be presented in other ways, such as in the form of lines such as drawing graphs reflecting different pressure drops in different intervals.

在本申请的进一步的实施例中,方法100还可以包括(未示出):响应于对连线上某个区间的两端位置之间的血压差的选定操作,显示相应的血压差值。在该实施例中,压力梯度图可以实现用户交互,通过用户选择,可以进一步呈现两个感兴趣位置之间的连线上任一区间的两端位置之间的血压差值,这有利于用户在了解两个感兴趣位置之间的压降趋势的同时,还能获得任一区间的降压定量数值结果,更有利于辅助医生诊断。In a further embodiment of the present application, the method 100 may further include (not shown): in response to the selected operation on the blood pressure difference between two ends of a certain interval on the line, displaying the corresponding blood pressure difference . In this embodiment, the pressure gradient map can realize user interaction. Through user selection, the blood pressure difference between the two ends of any interval on the line between two locations of interest can be further presented, which is beneficial for the user to While knowing the trend of pressure drop between two locations of interest, it can also obtain quantitative numerical results of blood pressure drop in any interval, which is more conducive to assisting doctors in diagnosis.

总体上,根据本申请实施例的超声血流参数的测量方法100基于向量血流速度计算局部血管压差,能够实现精确的局部压差计算,且无创又快捷;此外,根据本申请实施例的超声血流参数的测量方法基于目标血管超声图像上两个感兴趣位置之间区域的多处向量血流速度生成两个感兴趣位置之间的压力梯度图,能够实现两个感兴趣位置之间的压差变化趋势的直观呈现,通过不同的颜色准确定位异常位置,提示医生进行关注,从而更好地辅助医生诊断。In general, the ultrasonic blood flow parameter measurement method 100 according to the embodiment of the present application calculates the local vascular pressure difference based on the vector blood flow velocity, which can realize accurate calculation of the local pressure difference, and is non-invasive and fast; in addition, according to the embodiment of the present application The measurement method of ultrasonic blood flow parameters generates a pressure gradient map between two positions of interest based on multiple vector blood flow velocities in the area between two positions of interest on the ultrasound image of the target vessel, which can realize Intuitive presentation of the change trend of differential pressure, accurately locate the abnormal position through different colors, and prompt the doctor to pay attention, so as to better assist the doctor in diagnosis.

以上示例性地示出了根据本申请一个实施例的超声血流参数的测量方法。下面结合图5到图10描述根据本申请其他实施例的超声血流参数的测量方法。The above exemplarily shows a method for measuring ultrasonic blood flow parameters according to an embodiment of the present application. The method for measuring ultrasonic blood flow parameters according to other embodiments of the present application will be described below with reference to FIGS. 5 to 10 .

图5示出了根据本申请另一个实施例的超声血流参数的测量方法500的示意性流程图。如图5所示,超声血流参数的测量方法500可以包括如下步骤:Fig. 5 shows a schematic flowchart of a method 500 for measuring ultrasonic blood flow parameters according to another embodiment of the present application. As shown in FIG. 5, a method 500 for measuring ultrasonic blood flow parameters may include the following steps:

在步骤S510,获取目标血管的超声图像上的第一感兴趣位置和第二感兴趣位置。In step S510, a first position of interest and a second position of interest on the ultrasonic image of the target blood vessel are acquired.

在步骤S520,确定所述第一感兴趣位置和所述第二感兴趣位置之间的连线,其中所述连线包括划分的多个区间。In step S520, a connection line between the first location of interest and the second location of interest is determined, wherein the connection line includes a plurality of divided intervals.

在步骤S530,针对每个所述区间,获取所述区间的两端位置处的血流速度,并基于所述血流速度计算所述区间的两端位置之间的血压差。In step S530, for each interval, the blood flow velocity at the two ends of the interval is obtained, and the blood pressure difference between the two ends of the interval is calculated based on the blood flow velocity.

在步骤S540,基于每个所述区间的两端位置之间的血压差的大小在所述连线的不同区间上显示相应的颜色,以呈现所述第一感兴趣位置和所述第二感兴趣位置之间的血压差的变化趋势。In step S540, based on the magnitude of the blood pressure difference between the positions at both ends of each of the intervals, corresponding colors are displayed on different intervals of the connecting line, so as to present the first interest location and the second sense of interest. Trends in blood pressure differences between locations of interest.

在本申请的实施例中,超声血流参数的测量方法500与前文所述的超声血流参数的测量方法100相比,有部分相似,也有部分不同。具体地,步骤S510、S520以及S540分别与步骤S110、S120以及S140相同,只有步骤S530与步骤S130之间有一些差别。为了简洁,不再详细描述此处超声血流参数的测量方法500与前文所述的超声血流参数的测量方法100之间相同的部分,仅描述它们两者的不同部分。In the embodiment of the present application, the method 500 for measuring ultrasonic blood flow parameters is partly similar to and partly different from the aforementioned method 100 for measuring ultrasonic blood flow parameters. Specifically, steps S510, S520, and S540 are the same as steps S110, S120, and S140, respectively, and there are only some differences between steps S530 and S130. For the sake of brevity, the same parts between the method 500 for measuring ultrasonic blood flow parameters here and the method 100 for measuring ultrasonic blood flow parameters described above will not be described in detail, and only the different parts between them will be described.

在本申请的实施例中,超声血流参数的测量方法100在确定第一感兴趣位置和第二感兴趣位置之间的连线及其多个区间后,在步骤S130基于每个区间两端位置处的向量血流速度以及区间长度计算每个区间两端位置之间的血压差,而超声血流参数的测量方法500在确定第一感兴趣位置和第二感兴趣位置之间的连线及其多个区间后,在步骤S530基于每个区间两端位置处的血流速度(血流速度不限于是向量血流速度或基于脉冲多普勒所测得的血流速度,且无需确定区间长度)计算每个区间两端位置之间的血压差。以图4所示示例来描述,第一感兴趣位置A和第二感兴趣位置B之间任一区间的血压差可以通过如下公式(2)来计算:In the embodiment of the present application, after the measurement method 100 of ultrasonic blood flow parameters determines the line between the first position of interest and the second position of interest and its multiple intervals, in step S130 based on the two ends of each interval The vector blood flow velocity at the position and the interval length calculate the blood pressure difference between the positions at both ends of each interval, and the ultrasonic blood flow parameter measurement method 500 determines the connecting line between the first position of interest and the second position of interest After multiple intervals thereof, in step S530, based on the blood flow velocity at both ends of each interval (the blood flow velocity is not limited to the vector blood flow velocity or the blood flow velocity measured based on pulse Doppler, and there is no need to determine interval length) to calculate the blood pressure difference between the positions at both ends of each interval. Taking the example shown in FIG. 4 as an example, the blood pressure difference in any interval between the first location of interest A and the second location of interest B can be calculated by the following formula (2):

Figure BDA0003081340280000101
Figure BDA0003081340280000101

其中,i和j为第一感兴趣位置A和第二感兴趣位置B之间的连线上任意一个区间的两个端点(例如第一感兴趣位置A和第二感兴趣位置B之间的连线上相邻两点的位置),Δpij为该区间两个端点i和j之间的血压差,vi和vj分别为该区间两个端点i和j处各自的血流速度。Wherein, i and j are the two endpoints of any interval on the line between the first position of interest A and the second position of interest B (for example, the distance between the first position of interest A and the second position of interest B Δp ij is the blood pressure difference between the two endpoints i and j of the interval, and v i and v j are the respective blood flow velocities at the two endpoints i and j of the interval.

基于上述公式计算的血压差忽略了血粘度的影响,将血粘度假设为常数。因为,对于血液来讲,血流速度的变化虽然会导致血粘度的变化,但这种改变相对较小,也可忽略不计。这样的计算方式相对于公式(1)中的计算方式精度可能会下降一些,但是更为简便。The blood pressure difference calculated based on the above formula ignores the influence of blood viscosity, and assumes blood viscosity as a constant. Because, for blood, although changes in blood flow velocity will lead to changes in blood viscosity, this change is relatively small and can be ignored. Compared with the calculation method in formula (1), the accuracy of such a calculation method may be reduced, but it is more convenient.

在本申请的实施例中,步骤S530中获取的血流速度可以包括向量血流速度或者基于多点脉冲多普勒所测得的血流速度。其中,所述向量血流速度可以是通过斑点跟踪法、横向波振荡法或者基于多普勒原理的多角度偏转发射和/或接收方法计算得到的,其与前文所述类似,此处不再赘述。最后,基于各区间的两端位置处的血流速度,可以生成第一感兴趣位置和第二感兴趣位置之间的压力梯度图。In an embodiment of the present application, the blood flow velocity acquired in step S530 may include a vector blood flow velocity or a blood flow velocity measured based on multi-point pulse Doppler. Wherein, the vector blood flow velocity can be calculated by speckle tracking method, transverse wave oscillation method or multi-angle deflection transmission and/or reception method based on the Doppler principle, which is similar to that described above and will not be repeated here. repeat. Finally, a pressure gradient map between the first location of interest and the second location of interest may be generated based on the blood flow velocities at the locations at both ends of each interval.

基于上面的描述,根据本申请实施例的超声血流参数的测量方法500基于目标血管超声图像上两个感兴趣位置之间区域的多处血流速度生成两个感兴趣位置之间的压力梯度图,能够实现两个感兴趣位置之间的压差变化趋势的直观呈现,从而更好地辅助医生诊断。Based on the above description, the method 500 for measuring ultrasonic blood flow parameters according to an embodiment of the present application generates a pressure gradient between two positions of interest based on blood flow velocities at multiple places in the region between the two positions of interest on the ultrasound image of the target vessel The graph can realize the intuitive presentation of the pressure difference change trend between two locations of interest, so as to better assist doctors in diagnosis.

图6示出了根据本申请再一个实施例的超声血流参数的测量方法600的示意性流程图。如图6所示,超声血流参数的测量方法600可以包括如下步骤:Fig. 6 shows a schematic flowchart of a method 600 for measuring ultrasonic blood flow parameters according to yet another embodiment of the present application. As shown in FIG. 6, a method 600 for measuring ultrasonic blood flow parameters may include the following steps:

在步骤S610,沿至少两个不同的扫描角度向目标血管发射超声波,接收所述超声波的回波,并基于所述超声波的回波获得至少两组超声回波信号,其中每组超声回波信号源自一个扫描角度发射的超声波。In step S610, ultrasonic waves are transmitted to the target blood vessel along at least two different scanning angles, echoes of the ultrasonic waves are received, and at least two groups of ultrasonic echo signals are obtained based on the echoes of the ultrasonic waves, wherein each group of ultrasonic echo signals Ultrasonic waves emitted from a scanning angle.

在步骤S620,获取所述目标血管的超声图像上的第一感兴趣位置和第二感兴趣位置,以及所述第一感兴趣位置和所述第二感兴趣位置之间的长度。In step S620, a first position of interest and a second position of interest on the ultrasound image of the target blood vessel, and a length between the first position of interest and the second position of interest are acquired.

在步骤S630,基于所述至少两组超声回波信号分别得到所述第一感兴趣位置处的至少两个速度分量和所述第二感兴趣位置的至少两个速度分量,并将每个所述感兴趣位置处的至少两个速度分量合成得到每个所述感兴趣位置处的向量血流速度,其中每个速度分量源自一组超声回波信号。In step S630, at least two velocity components at the first location of interest and at least two velocity components at the second location of interest are respectively obtained based on the at least two groups of ultrasonic echo signals, and each of the At least two velocity components at the positions of interest are synthesized to obtain a vector blood flow velocity at each position of interest, wherein each velocity component is derived from a set of ultrasonic echo signals.

在步骤S640,基于所述第一感兴趣位置处的向量血流速度、所述第二感兴趣位置处的向量血流速度以及所述第一感兴趣位置和所述第二感兴趣位置之间的长度计算所述第一感兴趣位置与所述第二感兴趣位置之间的血压差。In step S640, based on the vector blood flow velocity at the first location of interest, the vector blood flow velocity at the second location of interest, and the distance between the first location of interest and the second location of interest The length of is to calculate the blood pressure difference between the first location of interest and the second location of interest.

在本申请的实施例中,超声血流参数的测量方法600通过多角度偏转发射/接收方法得到目标血管的超声图像上第一感兴趣位置和第二感兴趣位置各自的向量血流速度。下面以沿两个扫描角度为例来描述。通过超声探头沿第一扫描角度向目标血流区域发射超声波,接收从该目标血流区域返回的该超声波的超声回波。基于超声回波,获得沿该第一扫描角度的第一超声回波信号,根据该第一超声回波信号,得到目标血流区域内目标位置(在本申请实施例中包括第一感兴趣位置和第二感兴趣位置)的第一血流速度,该第一血流速度实际上是该目标位置的向量血流速度在该第一扫描角度上的投影分量(也可以称之为速度分量)。同样的,通过超声探头沿第二扫描角度向目标血流区域发射超声波,可得到该目标位置的第二血流速度,该第二血流速度实际上是该目标位置的向量血流速度在该第二扫描角度上的投影分量(也可以称之为速度分量)。对该第一血流速度和第二血流速度进行角度合成得到实际的速度大小和方向,即向量血流速度。通过上述的方式,可分别获得第一感兴趣位置处的向量血流速度和第二感兴趣位置处的向量血流速度。In the embodiment of the present application, the ultrasonic blood flow parameter measurement method 600 obtains the respective vector blood flow velocities of the first position of interest and the second position of interest on the ultrasonic image of the target blood vessel through a multi-angle deflection transmission/reception method. In the following, two scanning angles are taken as an example for description. The ultrasonic probe is used to transmit ultrasonic waves to the target blood flow area along the first scanning angle, and the ultrasonic echoes of the ultrasonic waves returned from the target blood flow area are received. Based on the ultrasonic echo, the first ultrasonic echo signal along the first scanning angle is obtained, and according to the first ultrasonic echo signal, the target position in the target blood flow area (including the first interest position in the embodiment of the present application) is obtained. and the first blood flow velocity of the second position of interest), the first blood flow velocity is actually the projected component of the vector blood flow velocity of the target position on the first scan angle (also called the velocity component) . Similarly, the second blood flow velocity at the target position can be obtained by transmitting ultrasonic waves to the target blood flow region through the ultrasonic probe along the second scanning angle, and the second blood flow velocity is actually the vector blood flow velocity of the target position at the target position. The projected component on the second scan angle (also called the velocity component). Angle synthesis is performed on the first blood flow velocity and the second blood flow velocity to obtain the actual magnitude and direction of the velocity, that is, the vector blood flow velocity. Through the above manner, the vector blood flow velocity at the first position of interest and the vector blood flow velocity at the second position of interest can be obtained respectively.

基于第一感兴趣位置和第二感兴趣位置各自的向量血流速度以及这两个位置之间的长度,可计算第一感兴趣位置与第二感兴趣位置之间的血压差。与前文实施例所述类似的,可以根据第一感兴趣位置和第二感兴趣位置所在的血管的走势自动生成第一感兴趣位置和第二感兴趣位置之间的连线,并基于所述连线确定第一感兴趣位置和第二感兴趣位置之间的长度;或者,根据所述第一感兴趣位置和所述第二感兴趣位置所在的血管的血流流动路径生成所述第一感兴趣位置和所述第二感兴趣位置之间的连线,并基于所述连线确定所述第一感兴趣位置和所述第二感兴趣位置之间的长度;又或者,获取用户在第一感兴趣位置和第二感兴趣位置之间描绘的连线,并基于所述连线确定第一感兴趣位置和第二感兴趣位置之间的长度。以图2所示示例来描述,第一感兴趣位置A和第二感兴趣位置B之间的血压差可以通过如下公式(3)来计算:Based on the respective vector blood flow velocities of the first location of interest and the second location of interest and the length between the two locations, a blood pressure difference between the first location of interest and the second location of interest may be calculated. Similar to the previous embodiments, the connection line between the first position of interest and the second position of interest can be automatically generated according to the trends of the blood vessels where the first position of interest and the second position of interest are located, and based on the A connecting line determines the length between the first position of interest and the second position of interest; or, the first position of interest is generated according to the blood flow path of the vessel where the first position of interest and the second position of interest are located. A connection line between the location of interest and the second location of interest, and based on the connection, determine the length between the first location of interest and the second location of interest; or, obtain the user's A connecting line is drawn between the first location of interest and the second location of interest, and based on the connecting line, the length between the first location of interest and the second location of interest is determined. Taking the example shown in FIG. 2 as an example, the blood pressure difference between the first location of interest A and the second location of interest B can be calculated by the following formula (3):

Figure BDA0003081340280000131
Figure BDA0003081340280000131

其中,ΔpAB为第一感兴趣位置A和第二感兴趣位置B之间的血压差,vA和vB分别为第一感兴趣位置A和第二感兴趣位置B各自的向量血流速度,lAB为第一感兴趣位置与第二感兴趣位置之间的长度,ρ是血液密度,t是时间变量。Among them, Δp AB is the blood pressure difference between the first location of interest A and the second location of interest B, v A and v B are the respective vector blood flow velocities of the first location of interest A and the second location of interest B , l AB is the length between the first position of interest and the second position of interest, ρ is the blood density, and t is the time variable.

因此,根据本申请实施例的超声血流参数的测量方法600基于多普勒原理的多角度偏转发射和/或接收方法计算得到目标血管的超声图像两个感兴趣位置各自的向量血流速度,并基于两个感兴趣位置之间的向量血流速度计算两个感兴趣位置之间的血压差,能够实现精确的局部压差计算,且无创又快捷。Therefore, according to the method 600 for measuring ultrasonic blood flow parameters according to the embodiment of the present application, the multi-angle deflection transmitting and/or receiving method based on the Doppler principle is used to calculate the vector blood flow velocities at two positions of interest in the ultrasonic image of the target blood vessel, And based on the vector blood flow velocity between the two positions of interest, the blood pressure difference between the two positions of interest can be calculated, which can realize accurate calculation of the local pressure difference, and is non-invasive and fast.

在本申请的进一步的实施例中,超声血流参数的测量方法600还可以包括如下步骤(未示出):获取所述目标血管的超声图像上的第三感兴趣位置,以及所述第一感兴趣位置和所述第三感兴趣位置之间的长度;基于所述至少两组超声回波信号得到所述第三感兴趣位置处的向量血流速度;基于所述第一感兴趣位置处的向量血流速度、所述第三感兴趣位置处的向量血流速度以及所述第一感兴趣位置和所述第三感兴趣位置之间的长度计算所述第一感兴趣位置与所述第三感兴趣位置之间的血压差,作为第二血压差;将所述第一感兴趣位置与所述第二感兴趣位置之间的血压差作为第一血压差,计算并输出所述第一血压差与所述第二血压差之间的差值。In a further embodiment of the present application, the method 600 for measuring ultrasonic blood flow parameters may further include the following steps (not shown): acquiring a third position of interest on the ultrasonic image of the target blood vessel, and the first The length between the position of interest and the third position of interest; the vector blood flow velocity at the third position of interest is obtained based on the at least two groups of ultrasonic echo signals; based on the position at the first position of interest The vector blood flow velocity at the third position of interest, the vector blood flow velocity at the third position of interest, and the length between the first position of interest and the third position of interest are used to calculate the relationship between the first position of interest and the The blood pressure difference between the third positions of interest is used as the second blood pressure difference; the blood pressure difference between the first position of interest and the second position of interest is used as the first blood pressure difference, and the first blood pressure difference is calculated and outputted. A difference between a first blood pressure difference and the second blood pressure difference.

在该实施例中,还获得目标血管的超声图像上的第三感兴趣位置,下面结合图7来描述。如图7所示,目标血管的超声图像上包括第一感兴趣位置A、第二感兴趣位置B和第三感兴趣位置C。其中,可通过前文所述的方式计算第一感兴趣位置A与第二感兴趣位置B之间的血压差作为第一血压差(如前文公式(3)所示的),并采用相同的方式计算第一感兴趣位置A与第三感兴趣位置C之间的血压差作为第二血压差,如下面的公式(4)所示的:In this embodiment, a third position of interest on the ultrasound image of the target blood vessel is also obtained, which will be described below with reference to FIG. 7 . As shown in FIG. 7 , the ultrasound image of the target blood vessel includes a first location of interest A, a second location of interest B, and a third location of interest C. Among them, the blood pressure difference between the first location of interest A and the second location of interest B can be calculated as the first blood pressure difference (as shown in the above formula (3)) by the method described above, and the same method is used Calculate the blood pressure difference between the first location of interest A and the third location of interest C as the second blood pressure difference, as shown in the following formula (4):

Figure BDA0003081340280000141
Figure BDA0003081340280000141

其中,ΔpAC为第一感兴趣位置A和第三感兴趣位置C之间的血压差,vA和vC分别为第一感兴趣位置A和第三感兴趣位置C各自的向量血流速度,lAC为第一感兴趣位置与第三感兴趣位置之间的长度,ρ是血液密度,t是时间变量。Among them, Δp AC is the blood pressure difference between the first location of interest A and the third location of interest C, v A and v C are the respective vector blood flow velocities of the first location of interest A and the third location of interest C , l AC is the length between the first position of interest and the third position of interest, ρ is the blood density, and t is the time variable.

在图7所示的示例中,示出了分叉血管示意图,例如颈动脉分叉,其中,第一感兴趣位置A处于颈总动脉中,第二感兴趣位置B处于颈内动脉中,第三感兴趣位置C处于颈外动脉中,因此,AB之间的血压差与AC之间的血压差之间的差值能够为医生提供更多的参考数据,使得医生了解在分叉血管中的压降对比情况。In the example shown in FIG. 7 , a schematic diagram of a bifurcated blood vessel is shown, such as a carotid artery bifurcation, wherein the first location of interest A is in the common carotid artery, the second location of interest B is in the internal carotid artery, and the second location of interest B is in the internal carotid artery. The third location of interest C is in the external carotid artery. Therefore, the difference between the blood pressure difference between AB and AC can provide more reference data for doctors, so that doctors can understand the blood pressure difference in bifurcation vessels. Pressure drop comparison.

图8示出了根据本申请又一个实施例的超声血流参数的测量方法800的示意性流程图。如图8所示,超声血流参数的测量方法800可以包括如下步骤:Fig. 8 shows a schematic flowchart of a method 800 for measuring ultrasonic blood flow parameters according to yet another embodiment of the present application. As shown in FIG. 8, a method 800 for measuring ultrasonic blood flow parameters may include the following steps:

在步骤S810,沿至少两个不同的扫描角度向目标血管发射超声波,接收所述超声波的回波,并基于所述超声波的回波获得至少两组超声回波信号,其中每组超声回波信号源自一个扫描角度发射的超声波。In step S810, ultrasonic waves are transmitted to the target blood vessel along at least two different scanning angles, echoes of the ultrasonic waves are received, and at least two groups of ultrasonic echo signals are obtained based on the echoes of the ultrasonic waves, wherein each group of ultrasonic echo signals Ultrasonic waves emitted from a scanning angle.

在步骤S820,获取所述目标血管的超声图像上的第一感兴趣位置和第二感兴趣位置。In step S820, a first position of interest and a second position of interest on the ultrasound image of the target blood vessel are acquired.

在步骤S830,基于所述至少两组超声回波信号分别得到每个所述感兴趣位置处的至少两个速度分量,并将每个所述感兴趣位置处的至少两个速度分量合成得到每个所述感兴趣位置处的向量血流速度,其中每个速度分量源自一组超声回波信号。In step S830, at least two velocity components at each position of interest are respectively obtained based on the at least two groups of ultrasonic echo signals, and at least two velocity components at each position of interest are synthesized to obtain each vector blood velocity at each of the locations of interest, wherein each velocity component is derived from a set of ultrasound echo signals.

在步骤S840,基于所述第一感兴趣位置处的向量血流速度和所述第二感兴趣位置处的向量血流速度计算所述第一感兴趣位置与所述第二感兴趣位置之间的血压差。In step S840, calculate the distance between the first position of interest and the second position of interest based on the vector blood flow velocity at the first position of interest and the vector blood flow velocity at the second position of interest poor blood pressure.

在本申请的实施例中,超声血流参数的测量方法800与前文所述的超声血流参数的测量方法600相比,有部分相似,也有部分不同。具体地,步骤S810和S830分别与步骤S610和S630,步骤S820与步骤S620有一些差别,步骤S840与步骤S640有一些差别。为了简洁,不再详细描述此处超声血流参数的测量方法800与前文所述的超声血流参数的测量方法600之间相同的部分,仅描述它们两者的不同部分。In the embodiment of the present application, the method 800 for measuring ultrasonic blood flow parameters is partly similar to and partly different from the aforementioned method 600 for measuring ultrasonic blood flow parameters. Specifically, steps S810 and S830 are different from steps S610 and S630, step S820 is different from step S620, and step S840 is different from step S640. For the sake of brevity, the same parts between the method 800 for measuring ultrasonic blood flow parameters and the method 600 for measuring ultrasonic blood flow parameters described above will not be described in detail, and only the different parts between them will be described.

在本申请的实施例中,超声血流参数的测量方法600在步骤S620获取第一感兴趣位置和第二感兴趣位置后,还需获取第一感兴趣位置和第二感兴趣位置之间的长度,在步骤S640基于两个感兴趣位置处各自的向量血流速度以及两个感兴趣位置之间的长度计算两个感兴趣位置之间的血压差,而超声血流参数的测量方法800在步骤S820获取第一感兴趣位置和第二感兴趣位置后,无需获取第一感兴趣位置和第二感兴趣位置之间的长度,在步骤S840基于两个感兴趣位置处各自的向量血流速度计算两个感兴趣位置之间的血压差。以图2示示例来描述,第一感兴趣位置A和第二感兴趣位置B之间的血压差可以通过如下公式(5)来计算:In the embodiment of the present application, after the method 600 for measuring ultrasonic blood flow parameters obtains the first and second positions of interest in step S620, the distance between the first and second positions of interest also needs to be obtained. length, in step S640, the blood pressure difference between the two positions of interest is calculated based on the respective vector blood flow velocities at the two positions of interest and the length between the two positions of interest, and the method 800 for measuring ultrasonic blood flow parameters is After obtaining the first location of interest and the second location of interest in step S820, there is no need to obtain the length between the first location of interest and the second location of interest. In step S840, based on the respective vector blood flow velocities at the two locations of interest Computes the difference in blood pressure between two locations of interest. Using the example shown in Figure 2 to describe, the blood pressure difference between the first location of interest A and the second location of interest B can be calculated by the following formula (5):

Figure BDA0003081340280000151
Figure BDA0003081340280000151

其中,ΔpAB为第一感兴趣位置A和第二感兴趣位置B之间的血压差,vA和vB分别为第一感兴趣位置A和第二感兴趣位置B各自的向量血流速度。Among them, Δp AB is the blood pressure difference between the first location of interest A and the second location of interest B, v A and v B are the respective vector blood flow velocities of the first location of interest A and the second location of interest B .

基于上述公式计算的血压差忽略了血粘度的影响,将血粘度假设为常数。因为,对于血液来讲,血流速度的变化虽然会导致血粘度的变化,但这种改变相对较小,也可忽略不计。这样的计算方式相对于公式(3)中的计算方式精度可能会下降一些,但是更为简便。此外,基于上述公式计算的血压差忽略了AB两点之间的血流速度变化,因此相对于公式(1)中的计算方式可能会有一点误差,但是更为简便。基于公式(5)计算压差时,需要同时测量两个位置的血流速度,传统脉冲多普勒是无法实现的,只有采用多点脉冲多普勒或者向量血流成像技术来实现同时测量不同位置的血流速度。The blood pressure difference calculated based on the above formula ignores the influence of blood viscosity, and assumes blood viscosity as a constant. Because, for blood, although changes in blood flow velocity will lead to changes in blood viscosity, this change is relatively small and can be ignored. Compared with the calculation method in formula (3), the accuracy of this calculation method may be reduced, but it is more convenient. In addition, the blood pressure difference calculated based on the above formula ignores the blood flow velocity change between the two points AB, so there may be a little error compared to the calculation method in formula (1), but it is more convenient. When calculating the pressure difference based on formula (5), it is necessary to measure the blood flow velocity at two positions simultaneously, which cannot be realized by traditional pulse Doppler. Blood flow velocity at the location.

基于上面的描述,根据本申请实施例的超声血流参数的测量方法800基于多普勒原理的多角度偏转发射和/或接收方法计算得到目标血管的超声图像两个感兴趣位置各自的向量血流速度,并基于两个感兴趣位置之间的向量血流速度计算两个感兴趣位置之间的血压差,能够实现精确的局部压差计算,且无创又快捷。Based on the above description, the ultrasonic blood flow parameter measurement method 800 according to the embodiment of the present application is based on the multi-angle deflection transmission and/or reception method of the Doppler principle to calculate the vector blood of the two interested positions of the ultrasonic image of the target blood vessel. Flow velocity, and calculate the blood pressure difference between the two locations of interest based on the vector blood flow velocity between the two locations of interest, can achieve accurate local pressure difference calculation, and non-invasive and fast.

在本申请的进一步的实施例中,超声血流参数的测量方法800还可以包括如下步骤(未示出):获取所述目标血管的超声图像上的第三感兴趣位置;基于所述至少两组超声回波信号得到所述第三感兴趣位置处的向量血流速度;基于所述第一感兴趣位置处的向量血流速度和所述第三感兴趣位置处的向量血流速度计算所述第一感兴趣位置与所述第三感兴趣位置之间的血压差,作为第二血压差;将所述第一感兴趣位置与所述第二感兴趣位置之间的血压差作为第一血压差,计算并输出所述第一血压差与所述第二血压差之间的差值。In a further embodiment of the present application, the method 800 for measuring ultrasonic blood flow parameters may further include the following steps (not shown): acquiring a third position of interest on the ultrasonic image of the target blood vessel; The vector blood flow velocity at the third position of interest is obtained by grouping ultrasonic echo signals; the vector blood flow velocity at the first position of interest and the vector blood flow velocity at the third position of interest are calculated based on The blood pressure difference between the first location of interest and the third location of interest is used as the second blood pressure difference; the blood pressure difference between the first location of interest and the second location of interest is used as the first Blood pressure difference, calculating and outputting the difference between the first blood pressure difference and the second blood pressure difference.

在该实施例中,还获得目标血管的超声图像上的第三感兴趣位置,可以仍结合图7来描述。如图7所示,目标血管的超声图像上包括第一感兴趣位置A、第二感兴趣位置B和第三感兴趣位置C。其中,可通过前文所述的方式计算第一感兴趣位置A与第二感兴趣位置B之间的血压差作为第一血压差(如前文公式(5)所示的),并采用相同的方式计算第一感兴趣位置A与第三感兴趣位置C之间的血压差作为第二血压差,如下面的公式(6)所示的:In this embodiment, a third position of interest on the ultrasound image of the target blood vessel is also obtained, which can still be described in conjunction with FIG. 7 . As shown in FIG. 7 , the ultrasound image of the target blood vessel includes a first location of interest A, a second location of interest B, and a third location of interest C. Among them, the blood pressure difference between the first location of interest A and the second location of interest B can be calculated as the first blood pressure difference (as shown in the above formula (5)) by the method described above, and the same method Calculate the blood pressure difference between the first location of interest A and the third location of interest C as the second blood pressure difference, as shown in the following formula (6):

Figure BDA0003081340280000161
Figure BDA0003081340280000161

其中,ΔpAC为第一感兴趣位置A和第三感兴趣位置C之间的血压差,vA和vC分别为第一感兴趣位置A和第三感兴趣位置C各自的向量血流速度。Among them, Δp AC is the blood pressure difference between the first location of interest A and the third location of interest C, v A and v C are the respective vector blood flow velocities of the first location of interest A and the third location of interest C .

在图7所示的示例中,示出了分叉血管示意图,例如颈动脉分叉,其中,第一感兴趣位置A处于颈总动脉中,第二感兴趣位置B处于颈内动脉中,第三感兴趣位置C处于颈外动脉中,因此,AB之间的血压差与AC之间的血压差之间的差值能够为医生提供更多的参考数据,使得医生了解在分叉血管中的压降对比情况。In the example shown in FIG. 7 , a schematic diagram of a bifurcated blood vessel is shown, such as a carotid artery bifurcation, wherein the first location of interest A is in the common carotid artery, the second location of interest B is in the internal carotid artery, and the second location of interest B is in the internal carotid artery. The third location of interest C is in the external carotid artery. Therefore, the difference between the blood pressure difference between AB and AC can provide more reference data for doctors, so that doctors can understand the blood pressure difference in bifurcation vessels. Pressure drop comparison.

图9示出了根据本申请一个实施例的眼部血管指数的测量方法900的示意性流程图。如图9所示,眼部血管指数的测量方法900可以包括如下步骤:Fig. 9 shows a schematic flowchart of a method 900 for measuring an ocular vascular index according to an embodiment of the present application. As shown in FIG. 9 , the method 900 for measuring the ocular vascular index may include the following steps:

在步骤S910,获取目标血管的超声图像上的第一感兴趣位置与第二感兴趣位置之间的血压差,其中,所述第一感兴趣位置和第二感兴趣位置分别位于颈总动脉内和颈内动脉内。In step S910, the blood pressure difference between the first position of interest and the second position of interest on the ultrasonic image of the target blood vessel is obtained, wherein the first position of interest and the second position of interest are respectively located in the common carotid artery and internal carotid artery.

在步骤S920,获取与所述颈内动脉连通的眼部血管的血流参数,所述血流参数包括收缩期峰值流速和舒张末期流速。In step S920, blood flow parameters of ocular blood vessels connected with the internal carotid artery are acquired, and the blood flow parameters include peak systolic flow velocity and end-diastolic flow velocity.

在步骤S930,计算所述收缩期峰值流速与舒张末期流速之间的速度差值,并计算和输出所述血压差与所述速度差值的比值。In step S930, the velocity difference between the systolic peak flow velocity and the end-diastolic flow velocity is calculated, and the ratio of the blood pressure difference to the velocity difference is calculated and output.

在本申请的实施例中,眼部血管指数的测量方法900结合颈内动脉压差计算眼部血管指数,能够为医生提供眼部疾病,尤其是缺血性眼部疾病的临床研究和相关诊断,稍后详细说明。其中,颈内动脉压差是指颈总动脉内与颈内动脉内之间的压差,因此获取的第一感兴趣位置和第二感兴趣位置分别位于颈总动脉内和颈内动脉内,第一感兴趣位置和第二感兴趣位置之间的血压差的计算可以如前文实施例中所述的。In the embodiment of the present application, the method 900 for measuring ocular vascular index combined with internal carotid artery pressure difference to calculate the ocular vascular index can provide doctors with clinical research and related diagnosis of eye diseases, especially ischemic eye diseases , detailed later. Wherein, the pressure difference of the internal carotid artery refers to the pressure difference between the common carotid artery and the internal carotid artery, so the acquired first position of interest and the second position of interest are respectively located in the common carotid artery and the internal carotid artery, The calculation of the blood pressure difference between the first location of interest and the second location of interest can be as described in the previous embodiments.

在一个实施例中,步骤S910中获取目标血管的超声图像上的第一感兴趣位置与第二感兴趣位置之间的血压差,可以包括:获取所述目标血管的超声图像上的第一感兴趣位置与第二感兴趣位置处各自的向量血流速度,以及所述第一感兴趣位置和第二感兴趣位置之间的长度;基于所述第一感兴趣位置处的向量血流速度、所述第二感兴趣位置处的向量血流速度以及所述第一感兴趣位置和所述第二感兴趣位置之间的长度计算所述第一感兴趣位置与所述第二感兴趣位置之间的血压差,如前文公式(3)所示的。In one embodiment, acquiring the blood pressure difference between the first position of interest and the second position of interest on the ultrasound image of the target blood vessel in step S910 may include: acquiring the first sense of interest on the ultrasound image of the target blood vessel The respective vector blood flow velocities at the position of interest and the second position of interest, and the length between the first position of interest and the second position of interest; based on the vector blood flow velocity at the first position of interest, The vector blood flow velocity at the second location of interest and the length between the first location of interest and the second location of interest calculate the distance between the first location of interest and the second location of interest The blood pressure difference between them is shown in formula (3) above.

在另一个实施例中,步骤S910中获取目标血管的超声图像上的第一感兴趣位置与第二感兴趣位置之间的血压差,可以包括:获取所述目标血管的超声图像上的第一感兴趣位置与第二感兴趣位置处各自的血流速度;基于所述第一感兴趣位置处的血流速度和所述第二感兴趣位置处的血流速度计算所述第一感兴趣位置与所述第二感兴趣位置之间的血压差,如前文公式(5)所示的。In another embodiment, acquiring the blood pressure difference between the first position of interest and the second position of interest on the ultrasonic image of the target blood vessel in step S910 may include: acquiring the first position of interest on the ultrasonic image of the target blood vessel The respective blood flow velocities at the location of interest and the second location of interest; calculating the first location of interest based on the blood flow velocity at the first location of interest and the blood flow velocity at the second location of interest The blood pressure difference with the second position of interest is shown in formula (5) above.

在再一个实施例中,步骤S910中获取目标血管的超声图像上的第一感兴趣位置与第二感兴趣位置之间的血压差,可以包括:获取所述目标血管的超声图像上的第一感兴趣位置与第二感兴趣位置之间的颈内动脉最大狭窄处的血流速度;基于所述颈内动脉最大狭窄处的血流速度计算所述第一感兴趣位置与所述第二感兴趣位置之间的血压差,该实施例中的计算方式可以如公式(7)所示:In yet another embodiment, acquiring the blood pressure difference between the first position of interest and the second position of interest on the ultrasonic image of the target blood vessel in step S910 may include: acquiring the first position of interest on the ultrasonic image of the target blood vessel The blood flow velocity at the maximum stenosis of the internal carotid artery between the position of interest and the second position of interest; the first position of interest and the second sense of interest are calculated based on the blood flow velocity at the maximum stenosis of the internal carotid artery The blood pressure difference between the positions of interest, the calculation method in this embodiment can be as shown in formula (7):

Figure BDA0003081340280000181
Figure BDA0003081340280000181

其中,Δp为第一感兴趣位置和第二感兴趣位置之间的血压差,vmax为第一感兴趣位置和第二感兴趣位置之间的颈内动脉最大狭窄处的血流速度。基于公式(7)计算的血压差忽略了血粘度的影响,将血粘度假设为常数,也忽略了两个感兴趣位置之间的血流速度变化,是基于一定假设测量的压差,假设血管狭窄处的血流速度远大于正常血管的血流速度。这样的计算方式前文所述的计算方式精度可能会下降一些,但是更为简便,因为只需测量最大血流速度即可,通过传统脉冲多普勒即可实现。Wherein, Δp is the blood pressure difference between the first location of interest and the second location of interest, and v max is the blood flow velocity at the maximum stenosis of the internal carotid artery between the first location of interest and the second location of interest. The blood pressure difference calculated based on formula (7) ignores the influence of blood viscosity, assumes blood viscosity as a constant, and also ignores the change of blood flow velocity between two interested locations, and is based on certain assumptions. The blood flow velocity in the stenosis is much higher than that in normal blood vessels. Such a calculation method may have lower accuracy than the calculation method described above, but it is more convenient, because it only needs to measure the maximum blood flow velocity, which can be realized by traditional pulse Doppler.

因此,在本申请的实施例中,基于超声血流成像的测量方法900可以基于通过传统脉冲多普勒方法测得的血流速度、通过多点脉冲多普勒所测得的血流速度或者通过向量血流速度(其中,所述向量血流速度是通过斑点跟踪法、横向波振荡法或者基于多普勒原理的多角度偏转发射和/或接收方法计算得到的)来计算颈内动脉压差。由于眼动脉是颈内动脉的一个分支,当颈动脉窦部有较大压降时,尤其是颈总动脉至颈内动脉段有较大压差的情况下,可能会影响远端眼动脉的供血。因此,眼部血管指数的测量方法900基于颈动脉窦处的压降情况,可计算出一个眼部供血情况相关的参数。下面结合图10来描述。Therefore, in the embodiment of the present application, the measurement method 900 based on ultrasonic blood flow imaging can be based on blood flow velocity measured by traditional pulse Doppler method, blood flow velocity measured by multi-point pulse Doppler or Calculate the internal carotid artery pressure by vector blood flow velocity (wherein, the vector blood flow velocity is calculated by speckle tracking method, transverse wave oscillation method or multi-angle deflection transmission and/or reception method based on Doppler principle) Difference. Since the ophthalmic artery is a branch of the internal carotid artery, when there is a large pressure drop in the carotid sinus, especially when there is a large pressure difference between the common carotid artery and the internal carotid artery, it may affect the distal ophthalmic artery. supply blood. Therefore, the method 900 for measuring the ocular vascular index can calculate a parameter related to the blood supply to the eye based on the pressure drop at the carotid sinus. It will be described below in conjunction with FIG. 10 .

如图10所示,示出了颈动脉分叉血管,第一感兴趣位置A处于颈总动脉,第二感兴趣位置B处于颈内动脉,颈内存在狭窄或斑块,颈内动脉与眼动脉连通。AB连线跨过颈内动脉斑块,或跨过颈内动脉狭窄处,然后得到AB之间的压降值Δp。接着,通过超声的方式(诸如基于脉冲多普勒方法)测量眼部血管的血流流速,可得到眼动脉、视网膜中央动脉、睫状动脉中的至少一项的血流参数,该血流参数包括收缩期峰值流速(PSV)和舒张末期流速(EDV)。可通过如下公式(8)计算新参数:As shown in Figure 10, the bifurcation of the carotid artery is shown, the first position of interest A is in the common carotid artery, the second position of interest B is in the internal carotid artery, there is stenosis or plaque in the carotid, the internal carotid artery and the eye arterial connection. The line AB crosses the internal carotid artery plaque, or across the internal carotid artery stenosis, and then the pressure drop value Δp between AB and AB is obtained. Then, by measuring the blood flow velocity of the eye vessels by means of ultrasound (such as based on the pulse Doppler method), the blood flow parameters of at least one of the ophthalmic artery, the central retinal artery, and the ciliary artery can be obtained. Including peak systolic velocity (PSV) and end-diastolic velocity (EDV). The new parameters can be calculated by the following formula (8):

Figure BDA0003081340280000191
Figure BDA0003081340280000191

其中,Q值越高说明眼部血管存在缺血的可能性越大,和/或,造成缺血的原因与颈动脉狭窄的相关性也越大。Q值越低,说明眼部血管存在缺血的可能性越小,或者说明受到颈动脉狭窄的影响越小。Wherein, the higher the Q value, the greater the possibility of ischemia in the ocular blood vessels, and/or the greater the correlation between the cause of ischemia and carotid artery stenosis. The lower the Q value, the less likely there is ischemia in the ocular blood vessels, or the less affected by carotid artery stenosis.

在本申请的进一步的实施例中,眼部血管指数的测量方法900还可以包括如下步骤(未示出):将所述比值(即上述的Q值)与预设阈值进行比较,并根据比较结果输出提示信息;当所述比值大于预设阈值时,所述提示信息包括:眼部血管存在缺血的可能性大,和/或造成缺血的原因与颈动脉狭窄高度相关;当所述比值小于预设阈值时,所述提示信息包括:眼部血管存在缺血的可能性小,或者,造成缺血的原因与颈动脉狭窄相关性小。In a further embodiment of the present application, the method 900 for measuring the ocular vascular index may also include the following steps (not shown): comparing the ratio (that is, the aforementioned Q value) with a preset threshold, and according to the comparison As a result, prompt information is output; when the ratio is greater than the preset threshold, the prompt information includes: there is a high possibility of ischemia in the eye vessels, and/or the cause of ischemia is highly related to carotid artery stenosis; when the When the ratio is smaller than the preset threshold, the prompt information includes: the possibility of ischemia in the eye vessels is low, or the cause of the ischemia has little correlation with carotid artery stenosis.

因此,根据本申请实施例的眼部血管指数的测量方法900基于颈动脉窦处的压降情况计算一个眼部供血情况相关的参数,能够为医生提供眼部疾病,尤其是缺血性眼部疾病的临床研究和相关诊断。Therefore, the method 900 for measuring ocular vascular index according to the embodiment of the present application calculates a parameter related to ocular blood supply based on the pressure drop at the carotid sinus, which can provide doctors with ocular diseases, especially ischemic ocular Clinical research and associated diagnosis of disease.

以上示例性地示出了根据本申请实施例的超声血流参数和眼部血管指数的测量方法。下面结合图11描述根据本申请另一方面提供的超声血流成像装置。图11示出了根据本申请实施例的超声血流成像装置1100的示意性结构框图。如图11所示,超声血流成像装置1100包括发射电路1120、接收电路1130、超声探头1110、处理器1140和显示器1150,其中:发射电路1120用于控制超声探头1110向目标对象的目标部位发射超声波;接收电路1130用于控制超声探头1110接收所述超声波的回波,并从所述超声波的回波获取超声回波信号;处理器1140用于基于所述超声回波信号进行超声血流成像,还用于执行前文所述的根据本申请实施例的超声血流参数或眼部血管指数的测量方法;显示器1150用于显示处理器1140输出的结果。本领域技术人员可以结合前文关于根据本申请实施例的超声血流参数或眼部血管指数的测量方法的描述理解根据本申请实施例的超声血流成像装置1100的结构及其操作,为了简洁,此处不再赘述超声血流成像装置1100各部件的具体细节操作。The above exemplarily shows the measurement method of the ultrasonic blood flow parameter and the ocular blood vessel index according to the embodiment of the present application. The ultrasonic blood flow imaging device provided according to another aspect of the present application will be described below with reference to FIG. 11 . Fig. 11 shows a schematic structural block diagram of an ultrasonic blood flow imaging device 1100 according to an embodiment of the present application. As shown in Figure 11, the ultrasonic blood flow imaging device 1100 includes a transmitting circuit 1120, a receiving circuit 1130, an ultrasonic probe 1110, a processor 1140 and a display 1150, wherein: the transmitting circuit 1120 is used to control the ultrasonic probe 1110 to transmit Ultrasound: the receiving circuit 1130 is used to control the ultrasonic probe 1110 to receive the echo of the ultrasonic wave, and obtain an ultrasonic echo signal from the echo of the ultrasonic wave; the processor 1140 is used to perform ultrasonic blood flow imaging based on the ultrasonic echo signal , is also used to execute the method for measuring ultrasonic blood flow parameters or ocular vascular index according to the embodiment of the present application described above; the display 1150 is used to display the result output by the processor 1140 . Those skilled in the art can understand the structure and operation of the ultrasonic blood flow imaging device 1100 according to the embodiment of the present application in combination with the foregoing description about the measurement method of the ultrasonic blood flow parameter or the ocular vascular index according to the embodiment of the present application. For the sake of brevity, The specific detailed operations of the components of the ultrasonic blood flow imaging device 1100 will not be repeated here.

基于上面的描述,根据本申请实施例的超声血流参数、眼部血管指数的测量方法和超声血流成像装置基于向量血流速度计算局部血管压差,能够实现精确的局部压差计算,且无创又快捷;此外,根据本申请实施例的超声血流参数的测量方法基于目标血管超声图像上两个感兴趣位置之间区域的多处向量血流速度生成两个感兴趣位置之间的压力梯度图,能够实现两个感兴趣位置之间的压差变化趋势的直观呈现,从而更好地辅助医生诊断;此外,基于眼部血管指数的测量方法基于颈动脉窦处的压降情况计算一个眼部供血情况相关的参数,能够为医生提供眼部疾病,尤其是缺血性眼部疾病的临床研究和相关诊断。Based on the above description, according to the embodiment of the present application, the ultrasonic blood flow parameters, the measurement method of the eye vascular index and the ultrasonic blood flow imaging device calculate the local blood vessel pressure difference based on the vector blood flow velocity, which can realize accurate local pressure difference calculation, and Non-invasive and fast; in addition, the method for measuring ultrasonic blood flow parameters according to the embodiment of the present application generates the pressure between two positions of interest based on multiple vector blood flow velocities in the area between two positions of interest on the ultrasonic image of the target vessel Gradient map, which can realize the intuitive presentation of the trend of pressure difference between two locations of interest, so as to better assist doctors in diagnosis; in addition, the measurement method based on ocular vascular index calculates a pressure drop based on the carotid sinus Parameters related to eye blood supply can provide doctors with clinical research and related diagnosis of eye diseases, especially ischemic eye diseases.

尽管这里已经参考附图描述了示例实施例,应理解上述示例实施例仅仅是示例性的,并且不意图将本申请的范围限制于此。本领域普通技术人员可以在其中进行各种改变和修改,而不偏离本申请的范围和精神。所有这些改变和修改意在被包括在所附权利要求所要求的本申请的范围之内。Although example embodiments have been described herein with reference to the accompanying drawings, it should be understood that the above-described example embodiments are exemplary only, and are not intended to limit the scope of the application thereto. Various changes and modifications can be made therein by those of ordinary skill in the art without departing from the scope and spirit of the application. All such changes and modifications are intended to be included within the scope of this application as claimed in the appended claims.

本领域普通技术人员可以意识到,结合本文中所公开的实施例描述的各示例的单元及算法步骤,能够以电子硬件、或者计算机软件和电子硬件的结合来实现。这些功能究竟以硬件还是软件方式来执行,取决于技术方案的特定应用和设计约束条件。专业技术人员可以对每个特定的应用来使用不同方法来实现所描述的功能,但是这种实现不应认为超出本申请的范围。Those skilled in the art can appreciate that the units and algorithm steps of the examples described in conjunction with the embodiments disclosed herein can be implemented by electronic hardware, or a combination of computer software and electronic hardware. Whether these functions are executed by hardware or software depends on the specific application and design constraints of the technical solution. Those skilled in the art may use different methods to implement the described functions for each specific application, but such implementation should not be regarded as exceeding the scope of the present application.

在本申请所提供的几个实施例中,应该理解到,所揭露的设备和方法,可以通过其它的方式实现。例如,以上所描述的设备实施例仅仅是示意性的,例如,所述单元的划分,仅仅为一种逻辑功能划分,实际实现时可以有另外的划分方式,例如多个单元或组件可以结合或者可以集成到另一个设备,或一些特征可以忽略,或不执行。In the several embodiments provided in this application, it should be understood that the disclosed devices and methods may be implemented in other ways. For example, the device embodiments described above are only illustrative. For example, the division of the units is only a logical function division. In actual implementation, there may be other division methods. For example, multiple units or components can be combined or May be integrated into another device, or some features may be omitted, or not implemented.

在此处所提供的说明书中,说明了大量具体细节。然而,能够理解,本申请的实施例可以在没有这些具体细节的情况下实践。在一些实例中,并未详细示出公知的方法、结构和技术,以便不模糊对本说明书的理解。In the description provided herein, numerous specific details are set forth. However, it is understood that the embodiments of the application may be practiced without these specific details. In some instances, well-known methods, structures and techniques have not been shown in detail in order not to obscure the understanding of this description.

类似地,应当理解,为了精简本申请并帮助理解各个发明方面中的一个或多个,在对本申请的示例性实施例的描述中,本申请的各个特征有时被一起分组到单个实施例、图、或者对其的描述中。然而,并不应将该本申请的方法解释成反映如下意图:即所要求保护的本申请要求比在每个权利要求中所明确记载的特征更多的特征。更确切地说,如相应的权利要求书所反映的那样,其发明点在于可以用少于某个公开的单个实施例的所有特征的特征来解决相应的技术问题。因此,遵循具体实施方式的权利要求书由此明确地并入该具体实施方式,其中每个权利要求本身都作为本申请的单独实施例。Similarly, it should be understood that in the description of the exemplary embodiments of the application, in order to streamline the application and to facilitate understanding of one or more of the various inventive aspects, various features of the application are sometimes grouped together into a single embodiment, figure , or in its description. This method of application, however, is not to be interpreted as reflecting an intention that the claimed application requires more features than are expressly recited in each claim. Rather, as the corresponding claims reflect, the inventive point lies in that the corresponding technical problem may be solved by using less than all features of a single disclosed embodiment. Thus, the claims following this Detailed Description are hereby expressly incorporated into this Detailed Description, with each claim standing on its own as a separate embodiment of this application.

本领域的技术人员可以理解,除了特征之间相互排斥之外,可以采用任何组合对本说明书(包括伴随的权利要求、摘要和附图)中公开的所有特征以及如此公开的任何方法或者设备的所有过程或单元进行组合。除非另外明确陈述,本说明书(包括伴随的权利要求、摘要和附图)中公开的每个特征可以由提供相同、等同或相似目的的替代特征来代替。It will be appreciated by those skilled in the art that all features disclosed in this specification (including accompanying claims, abstract and drawings) and all features of any method or apparatus so disclosed may be used in any combination, except where the features are mutually exclusive. process or unit. Each feature disclosed in this specification (including accompanying claims, abstract and drawings) may be replaced by alternative features serving the same, equivalent or similar purpose, unless expressly stated otherwise.

此外,本领域的技术人员能够理解,尽管在此所述的一些实施例包括其它实施例中所包括的某些特征而不是其它特征,但是不同实施例的特征的组合意味着处于本申请的范围之内并且形成不同的实施例。例如,在权利要求书中,所要求保护的实施例的任意之一都可以以任意的组合方式来使用。In addition, those skilled in the art will appreciate that although some embodiments described herein include some features included in other embodiments but not others, combinations of features from different embodiments are meant to be within the scope of the present application. and form different embodiments. For example, in the claims, any one of the claimed embodiments can be used in any combination.

本申请的各个部件实施例可以以硬件实现,或者以在一个或者多个处理器上运行的软件模块实现,或者以它们的组合实现。本领域的技术人员应当理解,可以在实践中使用微处理器或者数字信号处理器(DSP)来实现根据本申请实施例的物品分析设备中的一些模块的一些或者全部功能。本申请还可以实现为用于执行这里所描述的方法的一部分或者全部的超声血流成像装置程序(例如,计算机程序和计算机程序产品)。这样的实现本申请的程序可以存储在计算机可读介质上,或者可以具有一个或者多个信号的形式。这样的信号可以从因特网网站上下载得到,或者在载体信号上提供,或者以任何其他形式提供。The various component embodiments of the present application may be realized in hardware, or in software modules running on one or more processors, or in a combination thereof. Those skilled in the art should understand that a microprocessor or a digital signal processor (DSP) may be used in practice to implement some or all functions of some modules in the item analysis device according to the embodiment of the present application. The present application can also be implemented as an ultrasound blood flow imaging device program (for example, a computer program and a computer program product) for performing a part or all of the methods described herein. Such a program implementing the present application may be stored on a computer-readable medium, or may be in the form of one or more signals. Such a signal may be downloaded from an Internet site, or provided on a carrier signal, or provided in any other form.

应该注意的是上述实施例对本申请进行说明而不是对本申请进行限制,并且本领域技术人员在不脱离所附权利要求的范围的情况下可设计出替换实施例。在权利要求中,不应将位于括号之间的任何参考符号构造成对权利要求的限制。单词“包含”不排除存在未列在权利要求中的元件或步骤。位于元件之前的单词“一”或“一个”不排除存在多个这样的元件。本申请可以借助于包括有若干不同元件的硬件以及借助于适当编程的计算机来实现。在列举了若干超声血流成像装置的单元权利要求中,这些超声血流成像装置中的若干个可以是通过同一个硬件项来具体体现。单词第一、第二、以及第三等的使用不表示任何顺序。可将这些单词解释为名称。It should be noted that the above-mentioned embodiments illustrate rather than limit the application, and that those skilled in the art will be able to design alternative embodiments without departing from the scope of the appended claims. In the claims, any reference signs placed between parentheses shall not be construed as limiting the claim. The word "comprising" does not exclude the presence of elements or steps not listed in a claim. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements. The application can be implemented by means of hardware comprising several distinct elements, and by means of a suitably programmed computer. In the unit claim listing several ultrasonic blood flow imaging devices, several of these ultrasonic blood flow imaging devices may be embodied by the same hardware item. The use of the words first, second, and third, etc. does not indicate any order. These words can be interpreted as names.

以上所述,仅为本申请的具体实施方式或对具体实施方式的说明,本申请的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本申请揭露的技术范围内,可轻易想到变化或替换,都应涵盖在本申请的保护范围之内。本申请的保护范围应以权利要求的保护范围为准。The above is only the specific implementation of the application or the description of the specific implementation. The scope of protection of the application is not limited thereto. Any person familiar with the technical field can easily Any changes or substitutions that come to mind should be covered within the protection scope of the present application. The protection scope of the present application should be based on the protection scope of the claims.

Claims (19)

1. A method of measuring an ultrasonic blood flow parameter, the method comprising:
acquiring a first interest position and a second interest position on an ultrasonic image of a target blood vessel;
determining a line between the first location of interest and the second location of interest, wherein the line comprises a plurality of divided intervals;
for each interval, acquiring vector blood flow velocities at positions at two ends of the interval and an interval length of the interval, and calculating a blood pressure difference between the positions at the two ends of the interval based on the vector blood flow velocities and the interval length;
displaying corresponding colors on different sections of the connecting line based on the magnitude of the blood pressure difference between the two end positions of each section so as to present the variation trend of the blood pressure difference between the first interest position and the second interest position.
2. A method of measuring an ultrasonic blood flow parameter, the method comprising:
acquiring a connecting line drawn on an ultrasonic image of a target blood vessel by a user, wherein the connecting line comprises a plurality of divided intervals;
for each interval, acquiring vector blood flow velocities at positions at two ends of the interval and an interval length of the interval, and calculating a blood pressure difference between the positions at the two ends of the interval based on the vector blood flow velocities and the interval length;
and displaying corresponding colors on different sections of the connecting line based on the magnitude of the blood pressure difference between the two end positions of each section so as to present the variation trend of the blood pressure difference on the connecting line.
3. The method according to claim 1 or 2, wherein the vector blood flow velocity is calculated by a speckle tracking method, a transverse wave oscillation method, or a multi-angle deflection transmitting and/or receiving method based on the doppler principle.
4. The method of claim 1, wherein determining the connection between the first location of interest and the second location of interest comprises:
and automatically generating a connecting line between the first interesting position and the second interesting position according to the trend of the blood vessel in which the first interesting position and the second interesting position are positioned.
5. The method of claim 1, wherein determining the connection between the first location of interest and the second location of interest comprises:
generating a connecting line between the first and second locations of interest from a blood flow path of a blood vessel in which the first and second locations of interest are located.
6. The method according to claim 1 or 2, characterized in that the method further comprises:
in response to a selected manipulation of the blood pressure difference for an interval on the line, a corresponding blood pressure difference value is displayed.
7. The method according to claim 1 or 2, wherein when the magnitude of the blood pressure difference of a certain interval on the connection line is larger than a preset threshold value, it is indicated that the blood flow corresponding to the certain interval is abnormal.
8. A method of measuring an ultrasonic blood flow parameter, the method comprising:
transmitting ultrasonic waves to a target blood vessel along at least two different scanning angles, receiving echoes of the ultrasonic waves, and obtaining at least two groups of ultrasonic echo signals based on the echoes of the ultrasonic waves, wherein each group of ultrasonic echo signals is derived from the ultrasonic waves transmitted at one scanning angle;
acquiring a first position of interest and a second position of interest on an ultrasound image of the target vessel, and a length between the first position of interest and the second position of interest;
obtaining at least two velocity components at the first interest position and at least two velocity components at the second interest position respectively based on the at least two groups of ultrasonic echo signals, and synthesizing the at least two velocity components at each interest position to obtain a vector blood flow velocity at each interest position, wherein each velocity component is derived from one group of ultrasonic echo signals;
calculating a blood pressure difference between the first location of interest and the second location of interest based on the vector blood flow velocity at the first location of interest, the vector blood flow velocity at the second location of interest, and the length between the first location of interest and the second location of interest.
9. The method of claim 8, wherein the obtaining a length between the first location of interest and the second location of interest comprises:
and automatically generating a connecting line between the first interest position and the second interest position according to the trend of the blood vessel in which the first interest position and the second interest position are positioned, and determining the length between the first interest position and the second interest position based on the connecting line.
10. The method of claim 8, wherein the obtaining a length between the first location of interest and the second location of interest comprises:
generating a connecting line between the first interest position and the second interest position according to the blood flow path of the blood vessel in which the first interest position and the second interest position are located, and determining the length between the first interest position and the second interest position based on the connecting line.
11. The method according to any one of claims 8-10, further comprising:
acquiring a third location of interest on an ultrasound image of the target vessel and a length between the first location of interest and the third location of interest;
obtaining a vector blood flow velocity at the third location of interest based on the at least two sets of ultrasound echo signals;
calculating a blood pressure difference between the first location of interest and the third location of interest as a second blood pressure difference based on the vector blood flow velocity at the first location of interest, the vector blood flow velocity at the third location of interest, and the length between the first location of interest and the third location of interest;
calculating and outputting a difference between the first blood pressure difference and the second blood pressure difference, taking a blood pressure difference between the first interest location and the second interest location as a first blood pressure difference.
12. A method of measuring an ocular vascular index, the method comprising:
acquiring a blood pressure difference between a first interest position and a second interest position on an ultrasonic image of a target blood vessel, wherein the first interest position and the second interest position are respectively positioned in a common carotid artery and an internal carotid artery;
obtaining blood flow parameters of an ocular vessel communicating with the internal carotid artery, the blood flow parameters including a peak systolic flow rate and an end diastolic flow rate;
calculating a velocity difference between the peak systolic flow rate and the end diastolic flow rate, and calculating and outputting a ratio of the blood pressure difference to the velocity difference.
13. The method of claim 12, wherein the obtaining a blood pressure difference between a first location of interest and a second location of interest on an ultrasound image of a target vessel comprises:
acquiring respective vector blood flow velocities at a first and a second location of interest on an ultrasound image of the target vessel, and a length between the first and second location of interest;
calculating a blood pressure difference between the first and second locations of interest based on the vector blood flow velocity at the first location of interest, the vector blood flow velocity at the second location of interest, and the length between the first and second locations of interest.
14. The method of claim 12, wherein the obtaining a blood pressure difference between a first location of interest and a second location of interest on an ultrasound image of a target vessel comprises:
simultaneously obtaining respective blood flow velocities at a first interest position and a second interest position on an ultrasonic image of the target blood vessel based on a multipoint pulse Doppler method;
calculating a blood pressure difference between the first and second locations of interest based on the blood flow velocity at the first and second locations of interest.
15. The method of claim 12, wherein the obtaining a blood pressure difference between a first location of interest and a second location of interest on an ultrasound image of a target vessel comprises:
acquiring a blood flow velocity at a maximum stenosis of an internal carotid artery between a first interest position and a second interest position on an ultrasound image of the target vessel;
calculating a blood pressure difference between the first and second locations of interest based on a blood flow velocity at the maximum narrowing of the internal carotid artery.
16. The method according to any one of claims 12 to 15, further comprising:
comparing the ratio with a preset threshold value, and outputting prompt information according to a comparison result;
when the ratio is greater than a preset threshold, the prompt message includes: the ocular vessels are highly likely to have ischemia, and/or the cause of ischemia is highly correlated with carotid stenosis;
when the ratio is smaller than a preset threshold, the prompt message includes: the ocular vessels are less likely to have ischemia, or the cause of ischemia is less associated with carotid stenosis.
17. The method of any one of claims 12 to 15, wherein the peak systolic flow rate and the end diastolic flow rate are blood flow velocities measured based on pulse doppler.
18. The method of any one of claims 12 to 15, wherein the ocular vessel comprises at least one of an ocular artery, a central retinal artery, a ciliary artery.
19. An ultrasonic blood flow imaging apparatus, comprising a transmitting circuit, a receiving circuit, an ultrasonic probe, a processor and a display, wherein:
the transmitting circuit is used for controlling the ultrasonic probe to transmit ultrasonic waves to a target part of a target object;
the receiving circuit is used for controlling the ultrasonic probe to receive the echo of the ultrasonic wave and acquiring an ultrasonic echo signal from the echo of the ultrasonic wave;
the processor is used for carrying out ultrasonic blood flow imaging based on the ultrasonic echo signal;
the processor is further configured to perform the method of measuring an ultrasound blood flow parameter of any one of claims 1-18;
the display is used for displaying the result output by the processor.
CN202110567200.5A 2021-05-24 2021-05-24 Method and device for measuring ultrasonic blood flow parameters and ocular vascular indexes Pending CN115381489A (en)

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