CN115369644A - Medical and sanitary antibacterial blood coagulation and liquid absorption multifunctional non-woven material - Google Patents
Medical and sanitary antibacterial blood coagulation and liquid absorption multifunctional non-woven material Download PDFInfo
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- CN115369644A CN115369644A CN202210854985.9A CN202210854985A CN115369644A CN 115369644 A CN115369644 A CN 115369644A CN 202210854985 A CN202210854985 A CN 202210854985A CN 115369644 A CN115369644 A CN 115369644A
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- 239000000463 material Substances 0.000 title claims abstract description 83
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 23
- 239000007788 liquid Substances 0.000 title claims abstract description 23
- 230000023555 blood coagulation Effects 0.000 title claims abstract description 16
- 238000010521 absorption reaction Methods 0.000 title claims abstract description 13
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 55
- 239000004626 polylactic acid Substances 0.000 claims abstract description 55
- 229920001661 Chitosan Polymers 0.000 claims abstract description 30
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 239000008367 deionised water Substances 0.000 claims description 21
- 229910021641 deionized water Inorganic materials 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 238000001035 drying Methods 0.000 claims description 20
- 239000012535 impurity Substances 0.000 claims description 20
- 239000004744 fabric Substances 0.000 claims description 16
- 239000000843 powder Substances 0.000 claims description 16
- 238000005406 washing Methods 0.000 claims description 15
- 239000004745 nonwoven fabric Substances 0.000 claims description 14
- 238000000502 dialysis Methods 0.000 claims description 10
- 238000001291 vacuum drying Methods 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 230000036541 health Effects 0.000 claims description 7
- 238000004090 dissolution Methods 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 6
- 230000015271 coagulation Effects 0.000 claims description 5
- 238000005345 coagulation Methods 0.000 claims description 5
- 235000019441 ethanol Nutrition 0.000 claims description 5
- 238000007667 floating Methods 0.000 claims description 5
- 238000009832 plasma treatment Methods 0.000 claims description 5
- 230000001376 precipitating effect Effects 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 5
- 238000002791 soaking Methods 0.000 claims description 5
- 238000009210 therapy by ultrasound Methods 0.000 claims description 5
- PUVAFTRIIUSGLK-UHFFFAOYSA-M trimethyl(oxiran-2-ylmethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CC1CO1 PUVAFTRIIUSGLK-UHFFFAOYSA-M 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims 4
- 238000000034 method Methods 0.000 abstract description 5
- 206010052428 Wound Diseases 0.000 abstract description 4
- 208000027418 Wounds and injury Diseases 0.000 abstract description 4
- 238000005213 imbibition Methods 0.000 abstract description 4
- 230000004048 modification Effects 0.000 abstract description 3
- 238000012986 modification Methods 0.000 abstract description 3
- 239000002028 Biomass Substances 0.000 abstract description 2
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- 230000008569 process Effects 0.000 abstract description 2
- 238000011084 recovery Methods 0.000 abstract description 2
- 206010013786 Dry skin Diseases 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000007598 dipping method Methods 0.000 abstract 1
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- 239000001301 oxygen Substances 0.000 abstract 1
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- 239000004753 textile Substances 0.000 description 7
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- 208000035143 Bacterial infection Diseases 0.000 description 1
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 239000008280 blood Substances 0.000 description 1
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- 231100000956 nontoxicity Toxicity 0.000 description 1
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- 229920000642 polymer Polymers 0.000 description 1
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- 230000000638 stimulation Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M10/00—Physical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. ultrasonic, corona discharge, irradiation, electric currents, or magnetic fields; Physical treatment combined with treatment with chemical compounds or elements
- D06M10/04—Physical treatment combined with treatment with chemical compounds or elements
- D06M10/08—Organic compounds
- D06M10/10—Macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00987—Apparatus or processes for manufacturing non-adhesive dressings or bandages
- A61F13/00991—Apparatus or processes for manufacturing non-adhesive dressings or bandages for treating webs, e.g. for moisturising, coating, impregnating or applying powder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01008—Non-adhesive bandages or dressings characterised by the material
- A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06B—TREATING TEXTILE MATERIALS USING LIQUIDS, GASES OR VAPOURS
- D06B15/00—Removing liquids, gases or vapours from textile materials in association with treatment of the materials by liquids, gases or vapours
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06B—TREATING TEXTILE MATERIALS USING LIQUIDS, GASES OR VAPOURS
- D06B21/00—Successive treatments of textile materials by liquids, gases or vapours
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06B—TREATING TEXTILE MATERIALS USING LIQUIDS, GASES OR VAPOURS
- D06B3/00—Passing of textile materials through liquids, gases or vapours to effect treatment, e.g. washing, dyeing, bleaching, sizing, impregnating
- D06B3/10—Passing of textile materials through liquids, gases or vapours to effect treatment, e.g. washing, dyeing, bleaching, sizing, impregnating of fabrics
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- D06M10/00—Physical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. ultrasonic, corona discharge, irradiation, electric currents, or magnetic fields; Physical treatment combined with treatment with chemical compounds or elements
- D06M10/02—Physical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. ultrasonic, corona discharge, irradiation, electric currents, or magnetic fields; Physical treatment combined with treatment with chemical compounds or elements ultrasonic or sonic; Corona discharge
- D06M10/025—Corona discharge or low temperature plasma
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
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- A61F2013/00463—Plasters use haemostatic
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00727—Plasters means for wound humidity control
- A61F2013/00731—Plasters means for wound humidity control with absorbing pads
- A61F2013/00744—Plasters means for wound humidity control with absorbing pads containing non-woven
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F13/00—Bandages or dressings; Absorbent pads
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Abstract
The invention discloses a biodegradable antibacterial blood coagulation non-woven material for medical treatment and sanitation. Firstly, treating the polylactic acid melt-blown material by using low-temperature oxygen plasma to endow the polylactic acid melt-blown material with hydrophilicity, then quaternizing carboxymethyl chitosan to obtain amphoteric compound quaternizing carboxymethyl chitosan, and finally grafting quaternizing carboxymethyl chitosan on the polylactic acid melt-blown material subjected to hydrophilic modification by means of dipping to prepare the antibacterial blood coagulation imbibition multifunctional non-woven material. The multifunctional non-woven material obtained by the method is simple in process flow, adopts green and environment-friendly biomass materials, has good flexibility and air permeability to improve comfort, has strong liquid absorption capacity to quickly absorb liquid to keep skin dry and comfortable, and can promote blood coagulation and efficient bacteriostasis to facilitate recovery of wounds. Has important practical significance.
Description
Technical Field
The invention relates to a medical and sanitary non-woven material, in particular to an antibacterial blood coagulation liquid absorption multifunctional non-woven material for medical and sanitary use, belonging to the field of novel medical and sanitary textiles.
Background
As a novel professional field of the textile industry, the medical textile is rapidly developed in novel textile products of the textile industry along with the development of science and technology, combines medical science, biology and textile technology, and is medical equipment with high added value, which is prepared by taking natural materials and polymer synthetic materials as raw materials. Among them, the medical dressing is an indispensable position for the protection and cure of the wound surface as a product for external treatment. The ideal medical dressing not only has good isolation effect and bacterial infection prevention, but also needs to be helpful for wound recovery. In order to deal with different wounds, various medical dressings are produced, and natural abrasive cloth, synthetic fiber dressings, foam dressings, hydrogel and the like are common.
Chinese utility model patent CN214655605 discloses a medical dressing with water absorption, which adopts a three-layer structure comprising a fiber non-woven layer, a bonding layer and a medical protection pad. However, the medical dressing adopts the all-viscose fiber non-woven fabric, cannot be biodegraded, and has poor skin-friendly property. In addition, they lack the ability to prevent bacterial growth, promote blood clotting, and promote wound healing.
Along with the improvement of living standard of people and the enhancement of safety and sanitation consciousness of consumers, sanitary products become indispensable in life of people. Common hygiene articles include fecal hygiene articles such as diapers, feminine catamenial hygiene articles, skin and mucous membrane hygiene articles, and other disposable hygiene articles. An ideal sanitary article not only needs good liquid absorption capacity, skin friendliness and no toxicity, but also needs certain antibacterial performance to avoid breeding of bacteria.
Chinese utility model patent CN215689086U discloses a hydrophilic non-woven fabrics for hygienic products, the middle part region of non-woven fabrics sets up to central authorities and inhales the district that oozes, and central authorities inhale the upper and lower both sides in oozing the district and all are equipped with transversely and prevent the drain region, and central authorities inhale the left and right sides in oozing the district and all are equipped with vertically and prevent the drain region. However, the hydrophilic non-woven fabric has no antibacterial activity, is not biodegradable, is easy to breed bacteria, and is not beneficial to environmental protection.
Therefore, a multifunctional non-woven material which has better liquid absorption capacity, antibacterial performance and blood coagulation performance and can be used for medical treatment and health is developed.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides an antibacterial blood coagulation liquid absorption multifunctional non-woven material which can be used for medical treatment and sanitation, and has excellent performances such as better liquid absorption capacity, antibacterial performance, blood coagulation performance and the like.
In order to achieve the aim, the invention provides a multifunctional non-woven material for medical treatment and health, which adopts the following steps:
1) Cutting the polylactic acid melt-blown fabric into samples with the size of 100mm multiplied by 100mm, soaking the samples in absolute ethyl alcohol, sealing and storing the samples in a room temperature environment for 20 to 32 hours, and removing impurities contained in the non-woven fabric. Washing off the absolute ethyl alcohol in the non-woven fabric by using deionized water, and drying in a vacuum drying oven at 50-65 ℃ after complete washing to obtain the impurity-free polylactic acid non-woven material.
2) Taking the non-impurity PLA non-woven material with the size of 100mm multiplied by 100mm obtained in the step 1), and processing the non-impurity PLA non-woven material for 20 to 60 seconds under the condition that the power of the non-impurity PLA non-woven material in a plasma processor is 60 to 100W to obtain the hydrophilic modified PLA non-woven material.
3) Adding 1g carboxymethyl chitosan powder into a beaker filled with 20ml deionized water, fully stirring and dissolving, adding 2g 2, 3-epoxypropyl trimethyl ammonium chloride powder, and sealing the beaker and reacting for 24-48 h at 60 ℃. After the reaction is finished, pouring the solution into a dialysis bag for dialysis for three days, pouring the solution into absolute ethyl alcohol for alcohol precipitation and standing for a certain time, then centrifuging for 6-10 min by using a high-speed centrifuge at 8000-12000 rpm, pouring the centrifugal product into deionized water for dissolving, repeatedly precipitating and centrifuging for three times, finally placing the centrifuged product in a vacuum drying oven at 40 ℃ for hollow drying, and drying to obtain carboxymethyl chitosan quaternary ammonium salt powder;
4) 0.5-1.5 g of quaternized carboxymethyl chitosan is weighed and added into a conical flask, 100mL of deionized water is added, the mixture is stirred for 0.5 hour on a magnetic stirrer to be fully dissolved, and then ultrasonic treatment is carried out for 1min. Cutting 100mm multiplied by 100mm PLA melt-blown cloth in the step 2), putting the PLA melt-blown cloth into a 250mL beaker, pouring the dissolved quaternized carboxymethyl chitosan solution into the beaker, completely immersing the non-woven material into the solution, putting the non-woven material into a shaking table, shaking for 24-48 h at 37 ℃ and 170r/min, finally washing away floating liquid, and drying to obtain the antibacterial coagulation liquid-absorbing multifunctional non-woven material.
The polylactic acid non-woven material is a polylactic acid melt-blown material.
The low-temperature plasma treatment power is 60-100W, the treatment time is 20-60 s, and the concentration of the quaternized carboxymethyl chitosan solution is 0.5-1.5%.
The time for grafting the modified polylactic acid non-woven material by the quaternized carboxymethyl chitosan is 24-48 h.
Compared with the background art, the invention has the following excellent effects:
the multifunctional non-woven material for medical treatment and sanitation has the advantages of simple process flow, good liquid absorption, antibiosis and blood coagulation performances, good air permeability and softness, close to the skin and no stimulation to the skin. The quaternized carboxymethyl chitosan and the polylactic acid are biomass materials, are biodegradable, ecological and environment-friendly, and have important practical significance.
Drawings
Fig. 1 is an FTIR chart of the multifunctional nonwoven material for medical and hygienic prepared in example 1.
FIG. 2 is a graph showing the bacteriostatic rate of E.coli (S bacteria) of the multifunctional nonwoven material for medical treatment and hygiene prepared in example 1.
FIG. 3 is a static contact angle chart of the multifunctional nonwoven material for medical and hygienic prepared in example 3
FIG. 4 is a sample graph of the 1min liquid diffusion performance test of the multifunctional nonwoven material for medical and hygienic prepared in example 1
Detailed Description
The present invention will be further described with reference to the following specific examples.
Example 1:
1) Cutting polylactic acid melt-blown fabric into samples of 100mm multiplied by 100mm, soaking in absolute ethyl alcohol, sealing and storing for 24h at room temperature, and removing impurities contained in the non-woven fabric. And washing off the absolute ethyl alcohol in the non-woven fabric by using deionized water, and drying in a vacuum drying oven at 50 ℃ after complete washing to obtain the impurity-free polylactic acid non-woven material.
2) Taking the non-impurity PLA non-woven material with the thickness of 100mm multiplied by 100mm obtained in the step 1), and processing the non-impurity PLA non-woven material for 40s under the condition that the power of the non-impurity PLA non-woven material in a plasma processor is 80W to obtain the hydrophilic modified PLA non-woven material.
3) 1g carboxymethyl chitosan powder is added into a beaker filled with 20ml deionized water, after full stirring and dissolution, 2g 2, 3-epoxypropyl trimethyl ammonium chloride powder is added, and then the beaker is sealed and placed at 60 ℃ for reaction for 24 hours. After the reaction is finished, pouring the solution into a dialysis bag for dialysis for three days, pouring the solution into absolute ethyl alcohol for alcohol precipitation and standing for a certain time, then centrifuging the solution for 8min at 8000rpm by using a high-speed centrifuge, pouring a centrifugal product into deionized water for dissolution, repeatedly precipitating and centrifuging for three times, finally placing the centrifuged product in a vacuum drying oven at 40 ℃ for hollow drying, and obtaining carboxymethyl chitosan quaternary ammonium salt powder after drying;
4) Weighing 1.5g of quaternized carboxymethyl chitosan, adding into a conical flask, adding 100mL of deionized water, stirring on a magnetic stirrer for 0.5h to fully dissolve, and then carrying out ultrasonic treatment for 1min. Cutting 100mm multiplied by 100mm PLA melt-blown cloth in the step 2), putting the PLA melt-blown cloth into a 250mL beaker, pouring the dissolved quaternized carboxymethyl chitosan solution into the beaker, completely immersing the non-woven material into the solution, putting the non-woven material into a shaking table, shaking for 48h at the temperature of 37 ℃ and the speed of 170r/min, finally washing away the floating liquid, and drying to obtain the antibacterial coagulation imbibition multifunctional non-woven material (a).
Example 2:
1) Cutting the polylactic acid melt-blown fabric into a sample with the size of 100mm multiplied by 100mm, soaking the sample in absolute ethyl alcohol, sealing and storing the sample in a room temperature environment for 28 hours, and removing impurities contained in the non-woven fabric. And washing the anhydrous ethanol in the non-woven fabric by using deionized water, and drying in a vacuum drying oven at 55 ℃ after complete washing to obtain the impurity-free polylactic acid non-woven material.
2) Taking the non-impurity PLA non-woven material with the thickness of 100mm multiplied by 100mm obtained in the step 1), and treating the non-impurity PLA non-woven material for 60s under the condition that the power of the non-impurity PLA non-woven material in a plasma treatment instrument is 60W to obtain the hydrophilic modified PLA non-woven material.
3) 1g carboxymethyl chitosan powder is added into a beaker filled with 20ml deionized water, after full stirring and dissolution, 2g 2, 3-epoxypropyl trimethyl ammonium chloride powder is added, and then the beaker is sealed and placed at 60 ℃ for reaction for 26 hours. After the reaction is finished, pouring the solution into a dialysis bag for dialysis for three days, pouring the solution into absolute ethyl alcohol for alcohol precipitation and standing for a certain time, then centrifuging the solution for 10min at 8000rpm by using a high-speed centrifuge, pouring a centrifugal product into deionized water for dissolution, repeatedly precipitating and centrifuging for three times, finally placing the centrifuged product in a vacuum drying oven at 40 ℃ for hollow drying, and obtaining carboxymethyl chitosan quaternary ammonium salt powder after drying;
4) 0.5g of quaternized carboxymethyl chitosan is weighed into a conical flask, 100mL of deionized water is added, the mixture is stirred on a magnetic stirrer for 0.5h to be fully dissolved, and then ultrasonic treatment is carried out for 1min. Cutting 100mm multiplied by 100mm PLA melt-blown cloth in the step 2), putting the PLA melt-blown cloth into a 250mL beaker, pouring the dissolved quaternized carboxymethyl chitosan solution into the beaker, completely immersing the non-woven material into the solution, putting the non-woven material into a shaking table, shaking for 48h at the temperature of 37 ℃ and the speed of 170r/min, finally washing away the floating liquid, and drying to obtain the antibacterial coagulation imbibition multifunctional non-woven material (b).
Example 3:
1) Cutting polylactic acid melt-blown fabric into samples of 100mm multiplied by 100mm, soaking in absolute ethyl alcohol, sealing and storing for 30h at room temperature, and removing impurities contained in the non-woven fabric. And washing off the absolute ethyl alcohol in the non-woven fabric by using deionized water, and drying in a vacuum drying oven at 60 ℃ after complete washing to obtain the impurity-free polylactic acid non-woven material.
2) Taking the non-impurity PLA non-woven material with the thickness of 100mm multiplied by 100mm obtained in the step 1), and processing the non-impurity PLA non-woven material for 40s under the condition that the power of the non-impurity PLA non-woven material in a plasma processor is 100W to obtain the hydrophilic modified PLA non-woven material.
3) 1g carboxymethyl chitosan powder is added into a beaker filled with 20ml deionized water, after full stirring and dissolution, 2g 2, 3-epoxypropyl trimethyl ammonium chloride powder is added, and then the beaker is sealed and placed at 60 ℃ for reaction for 30 hours. After the reaction is finished, pouring the solution into a dialysis bag for dialysis for three days, pouring the solution into absolute ethyl alcohol for alcohol precipitation and standing for a certain time, then centrifuging for 6min by using a high-speed centrifuge at 12000rpm, pouring a centrifugal product into deionized water for dissolving, repeatedly precipitating and centrifuging for three times, finally placing the centrifuged product in a vacuum drying oven at 40 ℃ for hollow drying, and drying to obtain carboxymethyl chitosan quaternary ammonium salt powder;
4) Weighing 1.0g of quaternized carboxymethyl chitosan, adding into a conical flask, adding 100mL of deionized water, stirring on a magnetic stirrer for 0.5h to fully dissolve, and then carrying out ultrasonic treatment for 1min. Cutting 100mm multiplied by 100mm PLA melt-blown cloth in the step 2), putting the PLA melt-blown cloth into a 250mL beaker, pouring the dissolved quaternized carboxymethyl chitosan solution into the beaker, completely immersing the non-woven material into the solution, putting the non-woven material into a shaking table, shaking for 40h at the temperature of 37 ℃ and the speed of 170r/min, finally washing away the floating liquid, and drying to obtain the antibacterial coagulation imbibition multifunctional non-woven material (c).
As shown in FIG. 1, comparison of IR spectra of the multifunctional nonwoven material for medical and health applications prepared in example 1 revealed that the bulk structure of polylactic acid nonwoven material was not substantially changed by low-temperature plasma modification, as can be seen from the IR spectra of PLA-QCCS (P), 1592cm -1 The peak of C = N stretching vibration appears, and at the same time, 3358cm -1 The strengthening of the O-H and N-H stretching vibration peaks appears on the left and the right, which indicates that the QCCS is successfully grafted to the PLA melt-blown material. As shown in figure 2, the antibacterial rate of the multifunctional non-woven material for medical treatment and hygiene prepared in example 1 to escherichia coli reaches over 99% by adopting the standard of GB/T20944.3-2008 part 3 oscillation method for evaluating antibacterial performance of textiles. As shown in fig. 4, the multifunctional nonwoven material for medical and hygiene prepared in example 1 has a remarkably improved liquid absorption capacity within 1min as compared to the original PLA nonwoven material, and the diffusion areas of deionized water and whole blood are 10 times and 12 times, respectively, the diffusion area on the PLA nonwoven material. The multifunctional non-woven material for medical treatment and hygiene prepared has excellent antibacterial liquid absorption capacity.
Referring to fig. 3, the static contact angle graph of the multifunctional nonwoven material for medical and hygiene prepared in example 3, the contact angle of the PLA nonwoven material after the low-temperature plasma treatment was decreased from 117.9 ° to 50.5 °, and the contact angle after grafting the quaternized carboxymethyl chitosan was 50.9 °. The multifunctional non-woven material prepared by the method for medical treatment and hygiene has good hydrophilicity.
The foregoing lists merely exemplary embodiments of the invention. The present invention is not limited to the above embodiments, and many variations are possible. All modifications which can be derived or suggested by a person skilled in the art from the disclosure of the present invention are to be considered within the scope of the invention.
Claims (5)
1. An antibacterial blood coagulation liquid absorption multifunctional nonwoven material which can be used for medical treatment and sanitation, which is characterized by comprising the following steps:
1) Cutting the polylactic acid melt-blown fabric into samples with the size of 100mm multiplied by 100mm, soaking the samples in absolute ethyl alcohol, sealing and storing the samples in a room temperature environment for 20 to 32 hours, and removing impurities contained in the non-woven fabric. Washing off absolute ethyl alcohol in the non-woven fabric by using deionized water, and drying in a vacuum drying oven at 50-65 ℃ after complete washing to obtain the impurity-free polylactic acid non-woven material;
2) Taking the non-impurity PLA non-woven material with the size of 100mm multiplied by 100mm obtained in the step 1), and treating the non-impurity PLA non-woven material for 20 to 60 seconds under the condition that the power of the non-impurity PLA non-woven material in a plasma treatment instrument is 60 to 100W to obtain the hydrophilic modified PLA non-woven material;
3) 1g of carboxymethyl chitosan powder is added into a beaker filled with 20ml of deionized water, after the carboxymethyl chitosan powder is fully stirred and dissolved, 2g of 2, 3-epoxypropyl trimethyl ammonium chloride powder is added, and then the beaker is sealed and placed at 60 ℃ for reaction for 24-48 h. After the reaction is finished, pouring the solution into a dialysis bag for dialysis for three days, pouring the solution into absolute ethyl alcohol for alcohol precipitation and standing for a certain time, then centrifuging the solution for 6 to 10 minutes by using a high-speed centrifuge at 8000 to 12000rpm, pouring the centrifugal product into deionized water for dissolution, repeatedly precipitating and centrifuging the solution for three times, finally placing the centrifuged product in a vacuum drying oven at 40 ℃ for hollow drying, and obtaining carboxymethyl chitosan quaternary ammonium salt powder after drying;
4) 0.5-1.5 g of quaternized carboxymethyl chitosan is weighed and added into a conical flask, 100mL of deionized water is added, the mixture is stirred for 0.5h on a magnetic stirrer to be fully dissolved, and then ultrasonic treatment is carried out for 1min. Cutting 100mm multiplied by 100mm PLA melt-blown cloth in the step 2), putting the PLA melt-blown cloth into a 250mL beaker, pouring the dissolved quaternized carboxymethyl chitosan solution into the beaker, completely immersing the non-woven material into the solution, putting the non-woven material into a shaking table, shaking for 24-48 h at 37 ℃ and 170r/min, finally washing away floating liquid, and drying to obtain the antibacterial coagulation liquid-absorbing multifunctional non-woven material.
2. The preparation of antibacterial blood coagulation liquid suction multifunctional nonwoven material for medical and health use according to claim 1, characterized in that: the polylactic acid non-woven material is a polylactic acid melt-blown material.
3. The preparation of antibacterial blood coagulation liquid suction multifunctional nonwoven material for medical and health use according to claim 1, characterized in that: the low-temperature plasma treatment power is 60-100W, and the treatment time is 20-60 s.
4. The preparation of antibacterial blood coagulation liquid suction multifunctional nonwoven material for medical and health use according to claim 1, characterized in that: the concentration of the quaternized carboxymethyl chitosan solution is 0.5-1.5%.
5. The preparation of antibacterial blood coagulation liquid suction multifunctional nonwoven material for medical and health use according to claim 1, characterized in that: the time for grafting the modified polylactic acid non-woven material by the quaternized carboxymethyl chitosan is 24-48 h.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109224116A (en) * | 2018-09-01 | 2019-01-18 | 成都市水泷头化工科技有限公司 | A kind of the antibacterial anti hemorrhagic medical dressing and preparation method of high-absorbable |
| CN111996794A (en) * | 2020-08-28 | 2020-11-27 | 南通大学 | Preparation method of antibacterial polylactic acid non-woven material |
| CN112030559A (en) * | 2020-09-16 | 2020-12-04 | 长沙柔织新材料科技有限公司 | Preparation method of antibacterial non-woven fabric medical dressing |
| CN114381928A (en) * | 2022-01-25 | 2022-04-22 | 江阴天而然纺织科技有限公司 | Wool-like fiber fabric and processing technology thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109224116A (en) * | 2018-09-01 | 2019-01-18 | 成都市水泷头化工科技有限公司 | A kind of the antibacterial anti hemorrhagic medical dressing and preparation method of high-absorbable |
| CN111996794A (en) * | 2020-08-28 | 2020-11-27 | 南通大学 | Preparation method of antibacterial polylactic acid non-woven material |
| CN112030559A (en) * | 2020-09-16 | 2020-12-04 | 长沙柔织新材料科技有限公司 | Preparation method of antibacterial non-woven fabric medical dressing |
| CN114381928A (en) * | 2022-01-25 | 2022-04-22 | 江阴天而然纺织科技有限公司 | Wool-like fiber fabric and processing technology thereof |
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