CN115363985A - 一种保湿祛皱眼霜及其制备方法 - Google Patents
一种保湿祛皱眼霜及其制备方法 Download PDFInfo
- Publication number
- CN115363985A CN115363985A CN202211016105.7A CN202211016105A CN115363985A CN 115363985 A CN115363985 A CN 115363985A CN 202211016105 A CN202211016105 A CN 202211016105A CN 115363985 A CN115363985 A CN 115363985A
- Authority
- CN
- China
- Prior art keywords
- parts
- wrinkle
- moisturizing
- eye cream
- removing eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 38
- 239000006071 cream Substances 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 39
- 239000003906 humectant Substances 0.000 claims abstract description 31
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 26
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229930182478 glucoside Natural products 0.000 claims abstract description 26
- 150000008131 glucosides Chemical class 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 21
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 20
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 13
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 13
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 13
- 235000010254 Jasminum officinale Nutrition 0.000 claims abstract description 13
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 13
- 244000269722 Thea sinensis Species 0.000 claims abstract description 13
- 241001506047 Tremella Species 0.000 claims abstract description 13
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 13
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract description 13
- 239000002253 acid Substances 0.000 claims abstract description 13
- 229960001631 carbomer Drugs 0.000 claims abstract description 13
- 235000020710 ginseng extract Nutrition 0.000 claims abstract description 13
- 150000004676 glycans Chemical class 0.000 claims abstract description 13
- 229940101267 panthenol Drugs 0.000 claims abstract description 13
- 239000011619 pantothenol Substances 0.000 claims abstract description 13
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 13
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 13
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 13
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 13
- 239000005017 polysaccharide Substances 0.000 claims abstract description 13
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims abstract description 13
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 13
- 239000011718 vitamin C Substances 0.000 claims abstract description 13
- 241000195480 Fucus Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 27
- QNZANUZIBYJBIN-XSWJXKHESA-N (3s)-3-[[(2s)-2-acetamido-5-amino-5-oxopentanoyl]amino]-4-[[(2s)-1-[[(1s)-1-carboxy-2-(1h-imidazol-5-yl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound NC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 QNZANUZIBYJBIN-XSWJXKHESA-N 0.000 claims description 16
- SCAKQYSGEIHPLV-IUCAKERBSA-N (4S)-4-[(2-aminoacetyl)amino]-5-[(2S)-2-(carboxymethylcarbamoyl)pyrrolidin-1-yl]-5-oxopentanoic acid Chemical compound NCC(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O SCAKQYSGEIHPLV-IUCAKERBSA-N 0.000 claims description 16
- 108010047657 Phe-Val-Ala-Pro-Phe-Pro Proteins 0.000 claims description 16
- 229940086540 acetyl tetrapeptide-9 Drugs 0.000 claims description 16
- GFEYWOGCSROPRT-OBXVVNIGSA-N (2s)-1-[(2s)-2-[[(2s)-1-[(2s)-2-[[(2s)-2-[[(2s)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carboxylic acid Chemical compound C([C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(O)=O)C1=CC=CC=C1 GFEYWOGCSROPRT-OBXVVNIGSA-N 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 14
- 239000002904 solvent Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 241000207840 Jasminum Species 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- FHCLGDLYRUPKAM-UHFFFAOYSA-N 1,2,3-tribromopropane Chemical compound BrCC(Br)CBr FHCLGDLYRUPKAM-UHFFFAOYSA-N 0.000 claims description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 239000008103 glucose Substances 0.000 claims description 10
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 9
- 239000000010 aprotic solvent Substances 0.000 claims description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 7
- 239000003513 alkali Substances 0.000 claims description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 5
- 238000007599 discharging Methods 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000009849 vacuum degassing Methods 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- 239000004909 Moisturizer Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 230000001333 moisturizer Effects 0.000 claims description 3
- FDPIMTJIUBPUKL-UHFFFAOYSA-N dimethylacetone Natural products CCC(=O)CC FDPIMTJIUBPUKL-UHFFFAOYSA-N 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 239000002585 base Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 abstract description 11
- 108010035532 Collagen Proteins 0.000 abstract description 7
- 102000008186 Collagen Human genes 0.000 abstract description 7
- 229920001436 collagen Polymers 0.000 abstract description 7
- 230000003712 anti-aging effect Effects 0.000 abstract description 5
- 230000001153 anti-wrinkle effect Effects 0.000 abstract description 5
- 239000002537 cosmetic Substances 0.000 abstract description 4
- 230000037394 skin elasticity Effects 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 2
- 240000005385 Jasminum sambac Species 0.000 abstract 1
- 230000006872 improvement Effects 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 102000001187 Collagen Type III Human genes 0.000 description 6
- 108010069502 Collagen Type III Proteins 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 229920002674 hyaluronan Polymers 0.000 description 4
- 229960003160 hyaluronic acid Drugs 0.000 description 4
- 206010040914 Skin reaction Diseases 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000005282 brightening Methods 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 230000035483 skin reaction Effects 0.000 description 3
- 231100000430 skin reaction Toxicity 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 2
- 102000016942 Elastin Human genes 0.000 description 2
- 108010014258 Elastin Proteins 0.000 description 2
- 229920002549 elastin Polymers 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 229940118127 fucus vesiculosus extract Drugs 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 241000968420 Dynamena pumila Species 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 108010050808 Procollagen Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- -1 acetyl hexapeptide-11 Chemical compound 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000002508 compound effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000002431 foraging effect Effects 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
本发明提出了一种保湿祛皱眼霜及其制备方法，属于化妆品技术领域。由以下原料按重量份制备而成：肽类2‑4份、三聚葡萄糖苷保湿剂2‑4份、烟酰胺1‑3份、泛醇0.5‑1.5份、1,4‑丁二醇3‑5份、C10‑40异烷酸甘油三酯3‑5份、银耳多糖0.1‑2份、茉莉花提取物0.1‑2份、人参提取物0.1‑2份、墨角藻提取物0.1‑2份、维生素C 1‑2份、茶多酚0.5‑1份、卡波姆1‑2份、丙三醇4‑7份、水50‑60份。本发明制得的保湿祛皱眼霜制备方法简单，成本低廉，具有很好的保湿效果，能明显提高眼部皮肤的胶原蛋白含量，减少皱纹，提高皮肤弹性，具有抗衰、抗皱的效果，具有广阔的应用前景。
Description
技术领域
本发明涉及化妆品技术领域，具体涉及一种保湿祛皱眼霜及其制备方法。
背景技术
眼部周围的皮肤是人体中最薄最脆弱的地方，也是最容易衰老的地方，非常容易长出皱纹，需要特别的呵护，否则容易出现眼袋、皱纹、眼角下垂、黑眼圈等问题，因此越来越多的人开始注意眼部周围皮肤的护理，使用眼霜是十分必要的。市面上针对衰老和肌肤美化常用的即时护理手段主要有以下几种：(1)注射填充物，加强胶原蛋白和弹性蛋白基质，充盈肌肤；(2)注射内毒素，抑制肌肉收缩，即时淡化皱纹；(3)超声刀提拉除皱，即时紧致老化肌肤；(4)涂抹填充，物理遮盖细纹，达到视觉上即时淡纹；(5)补充水分，加强保湿护理，缓解减轻干纹。
现有技术中，专利文献CN112891290A公开了一种具有提亮眼角功效的眼霜，专利文献CN109864909A公开了一种淡纹眼霜，但是上述专利文献中的眼霜都只具有淡纹或提亮功效，不具备复合功效。申请人经过调研和检索后发现目前市面上鲜少出现有关即时提亮和即时淡纹于一体的功效护肤产品，且市面上现有护肤产品作用机理较为单一，如何能从上述护理手段中五个方向出发多维护理皮肤，达到即时美化肌肤的需求已成为现有技术亟需解决的问题。
发明内容
本发明的目的在于提出一种保湿祛皱眼霜及其制备方法，制得的保湿祛皱眼霜制备方法简单，成本低廉，具有很好的保湿效果，能明显提高眼部皮肤的胶原蛋白含量，减少皱纹，提高皮肤弹性，具有抗衰、抗皱的效果，具有广阔的应用前景。
本发明的技术方案是这样实现的：
本发明提供一种保湿祛皱眼霜，由以下原料按重量份制备而成：肽类2-4份、三聚葡萄糖苷保湿剂2-4份、烟酰胺1-3份、泛醇0.5-1.5份、1,4-丁二醇3-5份、C10-40异烷酸甘油三酯3-5份、银耳多糖0.1-2份、茉莉花提取物0.1-2份、人参提取物0.1-2份、墨角藻提取物0.1-2份、维生素C1-2份、茶多酚0.5-1份、卡波姆1-2份、丙三醇4-7份、水50-60份；
所述三聚葡萄糖苷保湿剂具有如式Ⅰ所示结构：
作为本发明的进一步改进，所述三聚葡萄糖苷保湿剂的制备方法如下：将1,2,3-三溴丙烷、葡萄糖、碱加入溶剂中混合均匀，加热反应，得到三聚葡萄糖苷保湿剂。
作为本发明的进一步改进，所述碱为KOH、NaOH、碳酸钠、碳酸钾中的至少一种。
作为本发明的进一步改进，所述溶剂为非质子性溶剂与二氯甲烷的混合物，体积比为3-5:2，所述非质子性溶剂选自二甲亚砜、丙酮、乙腈中的至少一种。
作为本发明的进一步改进，所述加热至温度为80-90℃，时间为3-5h，所述1,2,3-三溴丙烷、葡萄糖、碱的质量比为1:5-10:0.01-0.1。
作为本发明的进一步改进，所述三聚葡萄糖苷保湿剂的制备方法具体如下：将1重量份1,2,3-三溴丙烷、5-10重量份葡萄糖、0.01-0.1重量份碱加入溶剂中混合均匀，加热至80-90℃反应3-5h，过滤，滤液加入等体积的乙醇，过滤，洗涤，干燥，得到三聚葡萄糖苷保湿剂；所述溶剂为非质子性溶剂与二氯甲烷的混合物，体积比为3-5:2。
作为本发明的进一步改进，由以下原料按重量份制备而成：肽类3份、三聚葡萄糖苷保湿剂3份、烟酰胺2份、泛醇1份、1,4-丁二醇4份、C10-40异烷酸甘油三酯4份、银耳多糖1份、茉莉花提取物1份、人参提取物1份、墨角藻提取物1份、维生素C 2份、茶多酚0.7份、卡波姆1.5份、丙三醇5份、水55份。
作为本发明的进一步改进，所述肽类包括乙酰基四肽-9、六肽-11、四肽-4，质量比为3-5:5-7:1-2。
作为本发明的进一步改进，所述肽类包括乙酰基四肽-9、六肽-11、四肽-4，质量比为4:6:2。
本发明进一步保护一种上述保湿祛皱眼霜的制备方法，包括以下步骤：
(1)将三聚葡萄糖苷保湿剂、1,4-丁二醇、泛醇、C10-40异烷酸甘油三酯、烟酰胺、丙三醇和水加入反应釜，加热至50-60℃，300-500r/min搅拌10-15min，保温5-10min；
(2)将银耳多糖、茉莉花提取物、人参提取物、墨角藻提取物、维生素C、茶多酚、乙酰基四肽-9、六肽-11、四肽-4混合均匀，加入步骤(1)中，加入卡波姆，10000-12000r/min均质3-5min，真空脱气，出料，得到保湿祛皱眼霜。
本发明具有如下有益效果：本发明制备了一种三聚葡萄糖苷保湿剂，通过将葡萄糖与1,2,3-三溴丙烷反应制得，制备方法简单，糖苷化后制得的混合物的吸湿、保湿能力显著强于普通的保湿剂，制得的膏霜类化妆品具有更高的白度，滑爽无油腻感。
本发明肽类包括乙酰基四肽-9、六肽-11、四肽-4，乙酰基四肽-9能促进胶原蛋白合成，增加皮肤紧实度，六肽-11能抗衰、抗皱、提高皮肤弹性，四肽-4能减少皱纹，增强胶原蛋白，弹性蛋白和纤连蛋白，并具有强大的抗衰老特性，三者协同作用下，能明显提高眼部皮肤的胶原蛋白含量，减少皱纹，提高皮肤弹性，具有抗衰、抗皱的效果。
本发明制得的保湿祛皱眼霜制备方法简单，成本低廉，具有很好的保湿效果，能明显提高眼部皮肤的胶原蛋白含量，减少皱纹，提高皮肤弹性，具有抗衰、抗皱的效果，具有广阔的应用前景。
附图说明
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动性的前提下，还可以根据这些附图获得其他的附图。
图1为本发明三聚葡萄糖苷保湿剂的合成路线图。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
制备例1
如图1，三聚葡萄糖苷保湿剂的制备方法具体如下：将1重量份1,2,3-三溴丙烷、5重量份葡萄糖、0.01重量份KOH加入50重量份溶剂中混合均匀，加热至80℃反应3h，过滤，滤液加入等体积的乙醇，过滤，去离子水洗涤，70℃干燥2h，得到三聚葡萄糖苷保湿剂；所述溶剂为乙腈与二氯甲烷的混合物，体积比为3:2，ESMS计算值：C27H51O18(M+H)+663.30，实测值：663.3，收率为85％。
制备例2
如图1，三聚葡萄糖苷保湿剂的制备方法具体如下：将1重量份1,2,3-三溴丙烷、10重量份葡萄糖、0.1重量份KOH加入50重量份溶剂中混合均匀，加热至90℃反应5h，过滤，滤液加入等体积的乙醇，过滤，去离子水洗涤，70℃干燥2h，得到三聚葡萄糖苷保湿剂；所述溶剂为丙酮与二氯甲烷的混合物，体积比为5:2，收率为87％。
制备例3
如图1，三聚葡萄糖苷保湿剂的制备方法具体如下：将1重量份1,2,3-三溴丙烷、7重量份葡萄糖、0.05重量份NaOH加入50重量份溶剂中混合均匀，加热至85℃反应4h，过滤，滤液加入等体积的乙醇，过滤，去离子水洗涤，70℃干燥2h，得到三聚葡萄糖苷保湿剂；所述溶剂为二甲亚砜与二氯甲烷的混合物，体积比为4:2，收率为90％。
测试例1保湿率的测定
准确称取制备例1-3制得的三聚葡萄糖苷保湿剂、透明质酸各1g，配成质量分数为25％的溶液，置于恒温45℃，用饱和碳酸钠溶液维持相对湿度为50％±5％的干燥箱内，24h后称重。失水率(％)＝(W0-Wm)/H0×100％，W0、Wm分别为样品失水前后的质量，H0为失水前样品含水量。结果见表1。
表1
| 组别 | 失水率(％) |
| 制备例1 | 12.3 |
| 制备例2 | 12.0 |
| 制备例3 | 11.7 |
| 透明质酸 | 22.4 |
由上表可知，本发明制备例1-3制得的三聚葡萄糖苷保湿剂具有很好的保湿效果，明显强于透明质酸。
实施例1
本实施例提供保湿祛皱眼霜。
原料组成(重量份)：肽类2份、制备例1制得的三聚葡萄糖苷保湿剂2份、烟酰胺1份、泛醇0.5份、1,4-丁二醇3份、C10-40异烷酸甘油三酯3份、银耳多糖0.1份、茉莉花提取物0.1份、人参提取物0.1份、墨角藻提取物0.1份、维生素C1份、茶多酚0.5份、卡波姆1份、丙三醇4份、水50份。
所述肽类包括乙酰基四肽-9、六肽-11、四肽-4，质量比为3:5:1。
制备方法包括以下步骤：
(1)将三聚葡萄糖苷保湿剂、1,4-丁二醇、泛醇、C10-40异烷酸甘油三酯、烟酰胺、丙三醇和水加入反应釜，加热至50℃，300r/min搅拌10min，保温5min；
(2)将银耳多糖、茉莉花提取物、人参提取物、墨角藻提取物、维生素C、茶多酚、乙酰基四肽-9、六肽-11、四肽-4混合均匀，加入步骤(1)中，加入卡波姆，10000r/min均质3min，真空脱气，出料，得到保湿祛皱眼霜。
实施例2
本实施例提供保湿祛皱眼霜。
原料组成(重量份)：肽类4份、制备例2制得的三聚葡萄糖苷保湿剂4份、烟酰胺3份、泛醇1.5份、1,4-丁二醇5份、C10-40异烷酸甘油三酯5份、银耳多糖2份、茉莉花提取物2份、人参提取物2份、墨角藻提取物2份、维生素C2份、茶多酚1份、卡波姆2份、丙三醇7份、水60份。
所述肽类包括乙酰基四肽-9、六肽-11、四肽-4，质量比为5:7:2。
制备方法包括以下步骤：
(1)将三聚葡萄糖苷保湿剂、1,4-丁二醇、泛醇、C10-40异烷酸甘油三酯、烟酰胺、丙三醇和水加入反应釜，加热至60℃，500r/min搅拌15min，保温10min；
(2)将银耳多糖、茉莉花提取物、人参提取物、墨角藻提取物、维生素C、茶多酚、乙酰基四肽-9、六肽-11、四肽-4混合均匀，加入步骤(1)中，加入卡波姆，12000r/min均质5min，真空脱气，出料，得到保湿祛皱眼霜。
实施例3
本实施例提供保湿祛皱眼霜。
原料组成(重量份)：肽类3份、制备例3制得的三聚葡萄糖苷保湿剂3份、烟酰胺2份、泛醇1份、1,4-丁二醇4份、C10-40异烷酸甘油三酯4份、银耳多糖1份、茉莉花提取物1份、人参提取物1份、墨角藻提取物1份、维生素C 2份、茶多酚0.7份、卡波姆1.5份、丙三醇5份、水55份。
所述肽类包括乙酰基四肽-9、六肽-11、四肽-4，质量比为4:6:2。
制备方法包括以下步骤：
(1)将三聚葡萄糖苷保湿剂、1,4-丁二醇、泛醇、C10-40异烷酸甘油三酯、烟酰胺、丙三醇和水加入反应釜，加热至55℃，300-500r/min搅拌12min，保温7min；
(2)将银耳多糖、茉莉花提取物、人参提取物、墨角藻提取物、维生素C、茶多酚、乙酰基四肽-9、六肽-11、四肽-4混合均匀，加入步骤(1)中，加入卡波姆，11000r/min均质4min，真空脱气，出料，得到保湿祛皱眼霜。
实施例4
与实施例3相比，所述肽类包括乙酰基四肽-9、六肽-11，质量比为4:8，其他条件均不改变。
实施例5
与实施例3相比，所述肽类包括乙酰基四肽-9、四肽-4，质量比为4:8，他条件均不改变。
实施例6
与实施例3相比，所述肽类包括乙酰基六肽-11、四肽-4，质量比为10:2，他条件均不改变。
对比例1
与实施例3相比，制备例3制得的三聚葡萄糖苷保湿剂由透明质酸替代，其他条件均不改变。
对比例2
与实施例3相比，未添加制备例3制得的三聚葡萄糖苷保湿剂，其他条件均不改变。
对比例3
与实施例3相比，未添加肽类，其他条件均不改变。
测试例1皮肤斑贴试验
1.受试物：实施例1-6和对比例1-3制得的保湿祛皱眼霜。
2.阴性对照：去离子水
3.受试者：共30人，男0人，女30人，年龄20-45岁，符合受试者志愿入选标准。
4.斑贴方法：选用合格的斑试器，以封闭式斑贴试验方法，将受试物和阴性对照约0.02mL(膏体)滴于斑试器内，外用专用胶带贴敷于受试者背部不同部位，24h后去除受试物，分别去除后48h观察皮肤反应，按《化妆品卫生规范》(2007年版)中皮肤反应分级标准记录其结果。试验结果见表2：
表2
人体皮肤斑贴试验结果显示：30人中0例出现皮肤不良反应；说明本发明的保湿祛皱眼霜使用安全。
测试例2
将在含12％FBS的DMEM培养基中培养的人成纤维细胞播种于96孔板中，细胞附着后，用含有0.2％FBS和250μM抗坏血酸磷酸镁的DMEM培养基进行培养基交换，分别加入0.1mL实施例1-3和对比例1-3制得的保湿祛皱眼霜，混合均匀，培养72h后，收集上清，离心，测定所得上清中的Ⅲ型胶原蛋白的含量。
采用“RIA-gnost PⅢP(PⅢP)测定试剂盒”测定上清液中分泌的Ⅲ型胶原蛋白的末端肽(Procollagen typeⅢ-peptide：简称为PⅢP)的含量。通过Ⅲ型胶原蛋白的合成促进率进而评估这些样品的抗皱效果的强弱。计算公式如下：
促进率＝(W1-W0)/W0*100％
W1:添加测试样品后的Ⅲ型胶原蛋白生成量
W0:未添加测试样品的Ⅲ型胶原蛋白生成量
结果见表3。
表3
| 组别 | 促进率(％) |
| 实施例1 | 225 |
| 实施例2 | 232 |
| 实施例3 | 237 |
| 实施例4 | 198 |
| 实施例5 | 185 |
| 实施例6 | 201 |
| 对比例1 | 207 |
| 对比例2 | 212 |
| 对比例3 | 145 |
由上表可知，本发明实施例1-3制得的保湿祛皱眼霜具有明显的促进Ⅲ型胶原蛋白的效果，增厚细胞外基质，进而实现保湿抗皱效果。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (10)
1.一种保湿祛皱眼霜，其特征在于，由以下原料按重量份制备而成：肽类2-4份、三聚葡萄糖苷保湿剂2-4份、烟酰胺1-3份、泛醇0.5-1.5份、1,4-丁二醇3-5份、C10-40异烷酸甘油三酯3-5份、银耳多糖0.1-2份、茉莉花提取物0.1-2份、人参提取物0.1-2份、墨角藻提取物0.1-2份、维生素C1-2份、茶多酚0.5-1份、卡波姆1-2份、丙三醇4-7份、水50-60份；
所述三聚葡萄糖苷保湿剂具有如式Ⅰ所示结构：
2.根据权利要求1所述保湿祛皱眼霜，其特征在于，所述三聚葡萄糖苷保湿剂的制备方法如下：将1,2,3-三溴丙烷、葡萄糖、碱加入溶剂中混合均匀，加热反应，得到三聚葡萄糖苷保湿剂。
3.根据权利要求2所述保湿祛皱眼霜，其特征在于，所述碱为KOH、NaOH、碳酸钠、碳酸钾中的至少一种。
4.根据权利要求2所述保湿祛皱眼霜，其特征在于，所述溶剂为非质子性溶剂与二氯甲烷的混合物，体积比为3-5:2，所述非质子性溶剂选自二甲亚砜、丙酮、乙腈中的至少一种。
5.根据权利要求2所述保湿祛皱眼霜，其特征在于，所述加热至温度为80-90℃，时间为3-5h，所述1,2,3-三溴丙烷、葡萄糖、碱的质量比为1:5-10:0.01-0.1。
6.根据权利要求2所述保湿祛皱眼霜，其特征在于，所述三聚葡萄糖苷保湿剂的制备方法具体如下：将1重量份1,2,3-三溴丙烷、5-10重量份葡萄糖、0.01-0.1重量份碱加入溶剂中混合均匀，加热至80-90℃反应3-5h，过滤，滤液加入等体积的乙醇，过滤，洗涤，干燥，得到三聚葡萄糖苷保湿剂；所述溶剂为非质子性溶剂与二氯甲烷的混合物，体积比为3-5:2。
7.根据权利要求1所述保湿祛皱眼霜，其特征在于，由以下原料按重量份制备而成：肽类3份、三聚葡萄糖苷保湿剂3份、烟酰胺2份、泛醇1份、1,4-丁二醇4份、C10-40异烷酸甘油三酯4份、银耳多糖1份、茉莉花提取物1份、人参提取物1份、墨角藻提取物1份、维生素C 2份、茶多酚0.7份、卡波姆1.5份、丙三醇5份、水55份。
8.根据权利要求1所述保湿祛皱眼霜，其特征在于，所述肽类包括乙酰基四肽-9、六肽-11、四肽-4，质量比为3-5:5-7:1-2。
9.根据权利要求8所述保湿祛皱眼霜，其特征在于，所述肽类包括乙酰基四肽-9、六肽-11、四肽-4，质量比为4:6:2。
10.一种如权利要求1-7任一项所述保湿祛皱眼霜的制备方法，其特征在于，包括以下步骤：
(1)将三聚葡萄糖苷保湿剂、1,4-丁二醇、泛醇、C10-40异烷酸甘油三酯、烟酰胺、丙三醇和水加入反应釜，加热至50-60℃，300-500r/min搅拌10-15min，保温5-10min；
(2)将银耳多糖、茉莉花提取物、人参提取物、墨角藻提取物、维生素C、茶多酚、乙酰基四肽-9、六肽-11、四肽-4混合均匀，加入步骤(1)中，加入卡波姆，10000-12000r/min均质3-5min，真空脱气，出料，得到保湿祛皱眼霜。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211016105.7A CN115363985A (zh) | 2022-08-24 | 2022-08-24 | 一种保湿祛皱眼霜及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211016105.7A CN115363985A (zh) | 2022-08-24 | 2022-08-24 | 一种保湿祛皱眼霜及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115363985A true CN115363985A (zh) | 2022-11-22 |
Family
ID=84067021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211016105.7A Pending CN115363985A (zh) | 2022-08-24 | 2022-08-24 | 一种保湿祛皱眼霜及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115363985A (zh) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2009118836A (ru) * | 2009-05-20 | 2010-11-27 | Закрытое акционерное общество "Косметический центр "Лакрима" (RU) | Способ ухода за кожей вокруг глаз |
| CN103690447A (zh) * | 2013-12-25 | 2014-04-02 | 丘少荣 | 一种低激刺眼霜 |
| CN104434759A (zh) * | 2014-11-22 | 2015-03-25 | 沈阳源康医疗器械有限公司 | 一种含蛹虫草成分的眼霜及其制备方法 |
| CN107961191A (zh) * | 2017-12-28 | 2018-04-27 | 广州蜜妆生物科技有限公司 | 一种白松露抗衰老紧致眼膜及其制备方法 |
| CN108057016A (zh) * | 2016-11-09 | 2018-05-22 | 宋丛恺 | 一种抗老化眼霜 |
| CN109394653A (zh) * | 2018-12-29 | 2019-03-01 | 杭州菲丝凯化妆品有限公司 | 一种原液及其制备方法 |
| CN112426401A (zh) * | 2020-12-29 | 2021-03-02 | 广州葆雀化妆品有限公司 | 一种紧致柔嫩亮眼眼精华液及制备方法 |
-
2022
- 2022-08-24 CN CN202211016105.7A patent/CN115363985A/zh active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2009118836A (ru) * | 2009-05-20 | 2010-11-27 | Закрытое акционерное общество "Косметический центр "Лакрима" (RU) | Способ ухода за кожей вокруг глаз |
| CN103690447A (zh) * | 2013-12-25 | 2014-04-02 | 丘少荣 | 一种低激刺眼霜 |
| CN104434759A (zh) * | 2014-11-22 | 2015-03-25 | 沈阳源康医疗器械有限公司 | 一种含蛹虫草成分的眼霜及其制备方法 |
| CN108057016A (zh) * | 2016-11-09 | 2018-05-22 | 宋丛恺 | 一种抗老化眼霜 |
| CN107961191A (zh) * | 2017-12-28 | 2018-04-27 | 广州蜜妆生物科技有限公司 | 一种白松露抗衰老紧致眼膜及其制备方法 |
| CN109394653A (zh) * | 2018-12-29 | 2019-03-01 | 杭州菲丝凯化妆品有限公司 | 一种原液及其制备方法 |
| CN112426401A (zh) * | 2020-12-29 | 2021-03-02 | 广州葆雀化妆品有限公司 | 一种紧致柔嫩亮眼眼精华液及制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| 吕树祥: "《合成乙二醇葡萄糖苷的工艺条件对其保湿性能的影响》" * |
| 港雅（广东）生物科技有限公司: "《谜莎迪玻色因蛇毒肽抗皱热溶多效眼霜》" * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109875909A (zh) | 一种多肽组合抗衰功效化妆品 | |
| CN113274305B (zh) | 一种即时紧致去皱美白面膜液及其制备方法和应用 | |
| CN103385820A (zh) | 一种修护眼霜 | |
| CN110585048A (zh) | 一种具有抗糖化和抗氧化的组合物及其应用 | |
| CN106420472A (zh) | 一种多功能抗皱护肤品组合物及其制备方法 | |
| CN115006308A (zh) | 一种逆龄细致抗衰精华液 | |
| CN114504066A (zh) | 一种保湿抗皱胶原蛋白饮料及其制备方法 | |
| CN115363985A (zh) | 一种保湿祛皱眼霜及其制备方法 | |
| CN110917109A (zh) | 一种抗衰老面膜 | |
| CN109846798B (zh) | 一种紧致肌肤的组合物及包含该组合物的化妆品 | |
| CN110960481A (zh) | 一种增加外泌体产量的护肤品组合物的制备方法 | |
| CN114009794B (zh) | 具有延缓皮肤衰老功能的组合物及其应用 | |
| CN110934787B (zh) | 一种抗衰老组合物及其制备方法 | |
| KR102291780B1 (ko) | 천연 유래 물질을 포함하는 피부 노화 예방 및 상처 치유용 기능성 화장료 조성물 및 이의 제조방법 | |
| CN114869817A (zh) | 一种具有美白功效的组合物及其制备方法 | |
| EP3763225A1 (en) | Black rice extract ferments and the preparation methods and applications thereof | |
| CN103735455A (zh) | 一种紫菜水煮藻泥面膜及其制备方法 | |
| CN112957271A (zh) | 一种快速祛皱和抗衰的多肽组合物 | |
| CN110693800A (zh) | 一种纳米植萃面膜及其制备方法 | |
| KR20120030611A (ko) | 피부 개선용 건강 기능성 식품 조성물 | |
| CN110934815A (zh) | 一种含有间充质干细胞培养上清液的抗糖化面膜及其制备方法 | |
| CN117653563B (zh) | 一种高透皮性的重组胶原蛋白肽及其制备工艺和应用 | |
| CN116602910B (zh) | 寡肽组合物及其在制备皮肤修复及抗衰老产品上的应用 | |
| CN115708792B (zh) | 一种双靶点生成透明质酸及降低肌肤胶原蛋白流失的修护抗衰组合物及其制备方法和应用 | |
| CN113876833B (zh) | 白桑葚发酵物及其制备方法与用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20221122 |