CN115363563A - Optimized positioning device suitable for head nuclear magnetic resonance imaging - Google Patents

Optimized positioning device suitable for head nuclear magnetic resonance imaging Download PDF

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CN115363563A
CN115363563A CN202210988220.4A CN202210988220A CN115363563A CN 115363563 A CN115363563 A CN 115363563A CN 202210988220 A CN202210988220 A CN 202210988220A CN 115363563 A CN115363563 A CN 115363563A
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CN115363563B (en
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陈岗
宁伟
徐斌
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Zhejiang University ZJU
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/004Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/70Means for positioning the patient in relation to the detecting, measuring or recording means
    • A61B5/702Posture restraints
    • AHUMAN NECESSITIES
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    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
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    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/341Constructional details, e.g. resonators, specially adapted to MR comprising surface coils
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00Medical imaging apparatus involving image processing or analysis
    • A61B2576/02Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • A61B2576/026Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the brain

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Abstract

The invention discloses an optimized positioning device suitable for head nuclear magnetic resonance imaging, which is characterized in that a surface coil and a surface coil array are fixed in the center of a nuclear magnetic resonance static magnetic field and parallel to the trend of the magnetic field, and a target cortex is adjusted to be positioned in the center of the nuclear magnetic resonance magnetic field according to the head imaging area of a subject and is closer to the coil, so that the optimal imaging signal-to-noise ratio of the head imaging area of the subject can be obtained. Wherein the head fixing device comprises: the device comprises a coil fixing device which can be adjusted in the front-back up-down direction according to the head imaging area of a subject, a semi-cylindrical bottom support which can rotate in any direction of a nuclear magnetic resonance sickbed, a dental support which can be adjusted in angle, a head clamping device which can be adjusted in the front-back up-down direction according to the head size and the position of the subject, and a nuclear magnetic resonance sickbed clamping device. The stereotaxic apparatus achieves long-time, high-resolution, high-signal-to-noise-ratio brain imaging of a subject by nuclear magnetic resonance.

Description

Optimized positioning device suitable for head nuclear magnetic resonance imaging
Technical Field
The invention relates to the fields of biology, neuroscience, medicine and the like, in particular to the field of nuclear magnetic resonance subject imaging. In particular to an optimized positioning device suitable for head nuclear magnetic resonance imaging.
Background
The magnetic resonance imaging technique is widely applied due to its characteristics of higher resolution, non-invasiveness, full-scale imaging and the likeResearch in the fields of biomedicine and neuroscience. The design and development of the radio frequency coil are based on the physical basis of nuclear magnetic resonance signal generation and acquisition, wherein the horizontal direction parallel to a nuclear magnetic resonance sickbed is generally defined as the Z-axis direction, the direction perpendicular to the Z-axis direction and parallel to the horizontal plane of the nuclear magnetic resonance sickbed is defined as the Y-axis direction, and the direction perpendicular to the Z-axis direction and the Y-axis direction is defined as the X-axis direction. As previously described, the current in the radio frequency coil transmits an Electromagnetic (EM) field into the imaged object. The transmitted radio frequency field can be used as B 1 It is expressed in the nuclear magnetic resonance space as:
B 1 =xB 1x +yB 1y +zB 1z
but due to the nuclear magnetic resonance static magnetic field B 0 In the z-axis direction and centered on the z-axis as its most uniform position, according to the physical theory of mri, each mri signal comes from the transverse plane atomic spin flip, and the component in the z-axis does not generate spin flip, so the mri signal actually comes from the spin flip on the x-axis and y-axis to generate the component of the transverse magnetic field, and then the source of the mri signal can be generally expressed by the physical formula:
Figure BDA0003802901090000011
Figure BDA0003802901090000012
the nuclear magnetic resonance does not contribute to the signal in the Z-axis direction. When the brain cortex function activity related research is carried out, compared with a body coil and a body coil array, a surface coil and a surface coil array are used, the brain cortex function activity related research can obtain higher resolution and imaging signal to noise ratio when cortex imaging is carried out, wherein the head imaging position and the stability of the head of a subject play a vital role in the final imaging quality, the traditional nuclear magnetic resonance head positioning instrument cannot carry out angle adjustment on the head in the directions of an x axis and a y axis, the placing position of the coil during the nuclear magnetic resonance imaging can only be limited by the position of a target cortex, so that the surface coil and the surface coil array cannot be in the optimal position for exciting and receiving nuclear magnetic resonance signals, particularly in ultrahigh-field nuclear magnetic resonance, due to the limitation of the uniformity of an exciting coil, the optimal position adjustment on an imaging area cannot be carried out, and the optimal imaging signal to noise ratio of the coil cannot be obtained. Therefore, the invention provides a set of optimized positioning device suitable for head nuclear magnetic resonance imaging, solves the problem that the placement positions of a surface coil and a surface coil array of the traditional nuclear magnetic resonance positioning device can only be limited by the position of a target cortex, adjusts and optimizes the positions according to the physical basis of a nuclear magnetic resonance imaging signal source, and can be suitable for subjects with different brain scanning sizes.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides an optimized fixing device for controllably adjusting the position of a coil and the target brain area position of a subject according to the physical basis of a signal source of nuclear magnetic resonance imaging in order to obtain the optimal signal-to-noise ratio of the nuclear magnetic resonance imaging of the movement of the cortex of the head, solves the problem that the coil placement position of the conventional nuclear magnetic resonance positioning device is limited by the position of the cortex, realizes long-time high-resolution imaging scanning of a nuclear magnetic resonance subject, and provides technical support for researching the problems in the relevant fields of brain function movement, brain disease diagnosis and the like.
The purpose of the invention is realized by the following technical scheme: an optimized positioning device suitable for head magnetic resonance imaging, the optimized positioning device comprising: the device comprises an adjustable coil fixing device, a rotatable semi-cylindrical bottom support, a denture base capable of being angularly adjusted, an adjustable head imaging clamping device and a nuclear magnetic resonance sickbed clamping device;
the nuclear magnetic resonance sickbed clamping device is arranged on a nuclear magnetic resonance sickbed;
the adjustable coil fixture includes: the coil fixing cross rod can slide up and down in the grooves of the coil supporting parts; the coil supporting part is connected with the nuclear magnetic resonance sickbed clamping device; the surface coil is arranged on the coil fixing cross rod, and the positions of the surface coil and the surface coil array are adjusted through the front-back displacement of the whole sickbed and the up-down movement of the coil fixing cross rod;
the rotatable semi-cylindrical bottom support is arranged on a disc which freely rotates in the horizontal direction, the disc is arranged on a bottom plate, and the semi-cylindrical bottom support can rotate clockwise or anticlockwise in the cross section direction of the semi-cylindrical bottom support to adjust the horizontal direction of the head imaging area of the testee;
the angularly adjustable tray includes: the dental tray support component and the tooth clamping strip block; the denture supporting part is arc-shaped and is arranged on the rotatable semi-cylindrical bottom support, the tooth clamping strip block is clamped in an inner groove of the denture supporting part, and the rotation in a plane in the vertical direction of the longitudinal section of the semi-cylindrical bottom support is realized according to the radian of the denture supporting part, so that the position of head imaging is adjusted;
the head formation of image screens device with adjustable includes: the head clamping part comprises four clamping columns arranged on a rotatable semi-cylindrical bottom support, two supporting bars connected with each other in pairs of the clamping columns in the longitudinal section direction of the semi-cylindrical bottom support and a head clamping part connected between the two supporting bars in the horizontal direction; the middle parts of the four clamping columns are provided with clamping grooves which can be adjusted up and down, the two supporting bars are connected in the clamping grooves in a sliding mode, the clamping grooves which can be adjusted front and back are arranged on the two supporting bars, the head clamping part is connected in the clamping grooves in a sliding mode, and the head clamping part fixes the head in the optimal imaging position according to the size and the position of the head imaging area of the testee.
The nuclear magnetic resonance sickbed clamping device comprises two right-angle fixing blocks, two clamping grooves are formed in the right-angle surface of each right-angle fixing block, screws are fastened in the clamping grooves in the horizontal direction and can be installed on the nuclear magnetic resonance sickbed, the screws are fastened in the clamping grooves in the vertical direction and are connected with the coil fixing device, and the coil fixing device is moved up and down.
Furthermore, the angle of the denture base is adjusted by matching with the rotation of the semi-cylindrical bottom base, so that the target brain area is closer to the scanning coil, and the optimal radio frequency excitation efficiency and the imaging signal-to-noise ratio of the head imaging area of the subject are obtained.
Further, according to the size and the position of the head of the subject, the head imaging clamping device is adjusted in the front-back up-down direction; the matching coil fixing device is adjusted in the front-back up-down direction, so that the head imaging area of the subject is located at the optimal position, namely, the surface coil and the surface coil array are fixed at the center of the nuclear magnetic resonance static magnetic field and are parallel to the trend of the magnetic field, the optimal excitation radio frequency pulse and the optimal nuclear magnetic resonance signal of the coil are obtained, and the high-quality nuclear magnetic resonance brain imaging result is obtained.
The invention has the advantages of
Compared with the prior art, the invention has the unique effects that:
1. the coil fixing device can accurately fix the surface coil and the surface coil array at the center of a nuclear magnetic resonance static magnetic field and is parallel to the trend of the magnetic field, so that the coil can obtain high-efficiency radio frequency pulses.
2. The semi-cylindrical bottom support can be adjusted in a multi-angle rotating mode, and is matched with the angle adjustment of the dental support, so that the target cortex of a head imaging area of a subject is adjusted to be positioned at the center of a nuclear magnetic resonance magnetic field and is closer to a coil under the condition that the subject is in a comfortable body position, and therefore the optimal imaging signal-to-noise ratio of the head cortex imaging area of the subject can be obtained.
3. The head clamping device can adjust the position in the front, back, up and down directions according to the size and the position of the head of the subject, can effectively fix the head of the subject, and is convenient for carrying out long-time nuclear magnetic resonance brain imaging scanning.
Description of the drawings:
in order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
FIG. 1 is a block diagram of an optimized positioning device for magnetic resonance imaging of a head;
fig. 2 is a comparison diagram of the positional relationship between the head imaging region and the surface coil. The optimal positioning device is applied to adjust the orientation of the head to carry out imaging scanning under the condition of ensuring that the trend of the surface coil is parallel to the trend of the magnetic field; (b) The imaging target brain area is the occipital lobe, and the head position is adjusted to perform imaging scanning by applying the optimized positioning device under the condition of ensuring that the surface coil is parallel to the trend of the magnetic field.
The components in the figures are referenced with the following numerals: 1. a rotatable semi-cylindrical collet; 2. clamping the column; 3. a supporting strip; 4. a head retaining member; 5. the coil fixes the cross bar; 6. tooth screens strip piece; 7. a tray support member; 8. a coil support member; 9. a right-angle fixing block; 10. a disc; 11. a base plate.
Detailed Description
The following describes embodiments of the present invention in further detail with reference to the accompanying drawings.
As shown in fig. 1, in an embodiment of the present invention, an optimized positioning device for magnetic resonance imaging of a head is provided, the device includes: a rotatable semi-cylindrical collet 1; the head imaging clamping device (comprising four clamping columns 2, two supporting bars 3 and a clamping part 4) is adjustable front and back up and down; a denture base (comprising a denture base supporting part 7 and a denture base clamping block 6 which can adjust the angle in the vertical plane of the longitudinal section of the semi-cylindrical denture base 1); an adjustable coil fixing device (comprising a bottom plate 11, two coil supporting parts 8 and a coil fixing cross rod 5); a right-angle fixed block 9 which is fixed on the magnetic resonance sickbed clamping position and can be adjusted up and down, and a nuclear magnetic resonance sickbed clamping device.
The nuclear magnetic resonance sickbed clamping device is arranged on a nuclear magnetic resonance sickbed;
the main part of semicircle tubular collet 1 is semicircle tubular cylinder, through the screw fixation on the disc 10 on coil fixing device's bottom plate 11, cooperation disc 10 is the free rotation on the horizontal direction, and semicircle tubular collet 1 is clockwise or anticlockwise rotation on its cross section direction, and the horizontal direction of adjustment experimenter head imaging area realizes the rotation adjustment of formation of image position multi-angle.
The head formation of image screens device with adjustable contains: the semi-cylindrical bottom support comprises four clamping columns 2 arranged on a rotatable semi-cylindrical bottom support 1, two supporting bars 3 which are connected with each other in pairs of the clamping columns in the longitudinal section direction of the semi-cylindrical bottom support 1, and a head clamping part 4 which is connected between the two supporting bars 3 in the horizontal direction; the middle parts of the four clamping columns 2 are provided with clamping grooves which can be adjusted up and down, the two support bars 3 are connected in the clamping grooves in a sliding manner, the two support bars 3 are provided with clamping grooves which can be adjusted front and back, and the head clamping part 4 is connected in the clamping grooves in a sliding manner; the supporting bars 3 can be adjusted up and down in X-axis and Z-axis planes; the position blocking part 4 can be adjusted back and forth in the plane of the Y axis and the Z axis according to the size and the position of the head imaging area, and the head blocking part 4 fixes the head at the optimal imaging orientation according to the size and the position of the head imaging area of the subject.
The denture base capable of being angularly adjusted is composed of an arc denture base supporting part 7 fixed on the semi-cylindrical bottom base 1 and a tooth clamping strip block 6, the tooth clamping strip block 6 is clamped in an inner groove of the denture base supporting part 7, and rotation in a plane in the vertical direction of the longitudinal section of the semi-cylindrical bottom base 1 is realized according to the radian of the denture base supporting part 7, namely, rotation in the X-axis and Z-axis planes according to the radian of the denture base supporting part is realized so as to adjust the head imaging area. The angle of the denture base is adjusted by matching with the rotation of the semi-cylindrical bottom base 1, so that the target brain area is closer to the scanning coil, and the optimal radio frequency excitation efficiency and the imaging signal-to-noise ratio of the head imaging area of the testee are obtained. The adjustable head imaging clamping device can ensure high-quality magnetic resonance brain imaging scanning for hours, and can realize the magnetic resonance brain imaging scanning of experimental animals for not less than ten hours for research-type subject experiments.
The coil fixing device includes: two coil supporting parts 8 fixed on the clamping device of the nuclear magnetic resonance sickbed, a bottom plate 11 connected with the bottoms of the coil supporting parts 8, a coil fixing cross rod 5 capable of sliding up and down in a groove of the coil supporting parts 8, and a coil caliper with adjustable tightness and arranged in the middle of the fixing cross rod. The front and back adjustment of the whole device is realized by adjusting the screw fixing positions of the coil supporting part 8 and a right-angle fixing block 9 of the nuclear magnetic resonance sickbed clamping device, the surface coil is arranged on the coil fixing cross rod 5 in cooperation with the adjustment of the coil fixing cross rod 5 in the clamping groove position of the supporting part 8, and the positions of the surface coil and the surface coil array are adjusted by the front and back displacement of the whole sickbed and the up and down movement of the coil fixing cross rod 5; optimal radio frequency coil transmission efficiency can be achieved.
The nuclear magnetic resonance sickbed clamping device is composed of two L-shaped right-angle fixing blocks 9, two clamping grooves capable of being fixed by screws are formed in the right-angle surface of each right-angle fixing block (9), the screws are fastened into the clamping grooves in the horizontal direction and can be installed on the nuclear magnetic resonance sickbed, the screws are fastened into the clamping grooves in the vertical direction and are connected with the coil fixing device, and up-and-down adjustment in X-axis and Y-axis planes and left-and-right adjustment in X-axis and Z-axis planes are achieved.
According to the size and the position of the head of the testee, the head imaging clamping device is adjusted in the front-back and up-down directions; the matching coil fixing device is adjusted in the front-back up-down direction, so that the head imaging area of the subject is positioned at the optimal position, namely, the surface coil and the surface coil array are fixed at the center of the nuclear magnetic resonance static magnetic field and are parallel to the trend of the magnetic field, the optimal excitation radio frequency pulse and the optimal nuclear magnetic resonance signal of the coil are obtained, and the high-quality nuclear magnetic resonance brain imaging result is obtained.
When the imaging region of the subject is located in the prefrontal lobe brain region, as shown in (a) of fig. 2, the imaging target brain region is the prefrontal lobe, and the head orientation is adjusted to perform imaging scanning by applying the optimized positioning device under the condition of ensuring that the surface coil is parallel to the magnetic field trend; when the conventional head stereotaxic apparatus is used, the position of the head cannot be adjusted, when the surface coil is close to the forehead brain area, the coil and the coil array cannot be parallel to the trend of the magnetic field, the obtained imaging quality is poor, and the detail condition of the brain area cannot be judged. After the optimized positioning device is used, the surface coil is preferentially ensured to be parallel to the magnetic field direction by adjusting the coil fixing device, and then the forehead brain area of the subject is enabled to be close to the surface coil to the maximum extent by utilizing the combined action of the rotation adjusting functions of the semi-cylindrical bottom support and the dental support of the device, so that the structural image signal condition of the forehead brain area of the subject is obtained, and the imaging result has high signal-to-noise ratio.
When the imaging region of the subject is located in the occipital lobe brain region, as shown in (b) of fig. 2, the imaging target brain region is the occipital lobe, and the optimal positioning device is applied to adjust the head direction to perform imaging scanning under the condition of ensuring that the surface coil is parallel to the trend of the magnetic field.
In summary, the present invention is a magnetic compatible head stereotaxic apparatus suitable for nuclear magnetic resonance, which optimizes the optimal signal-to-noise ratio during head imaging, and provides technical support for brain function research and brain disease diagnosis, and for obtaining accurate brain images with improved resolution.
The above-described embodiments are intended to illustrate rather than to limit the invention, and any modifications and variations of the present invention are within the spirit of the invention and the scope of the appended claims.

Claims (4)

1. An optimized positioning device suitable for head magnetic resonance imaging, the optimized positioning device comprising: the adjustable coil fixing device, the rotatable semi-cylindrical bottom support (1), the denture base capable of carrying out angle adjustment, the adjustable head imaging clamping device and the nuclear magnetic resonance sickbed clamping device;
the nuclear magnetic resonance sickbed clamping device is arranged on a nuclear magnetic resonance sickbed;
the adjustable coil fixture includes: the coil fixing cross rod (5) can slide up and down in a groove of the coil supporting part (8); the coil supporting part (8) is connected with the nuclear magnetic resonance sickbed clamping device; the surface coil is arranged on the coil fixing cross rod (5), and the positions of the surface coil and the surface coil array are adjusted through the front-back displacement of the whole sickbed and the up-down movement of the coil fixing cross rod (5);
the rotatable semi-cylindrical bottom support (1) is arranged on a disc (10) which freely rotates in the horizontal direction, the disc (10) is arranged on a bottom plate (11), and the semi-cylindrical bottom support (1) can rotate clockwise or anticlockwise in the cross section direction of the semi-cylindrical bottom support to adjust the horizontal direction of a head imaging area of a testee;
the angularly adjustable tray includes: a denture supporting part (7) and a tooth clamping strip block (6); the denture base supporting part (7) is arc-shaped and is arranged on the rotatable semi-cylindrical bottom base (1), and the tooth clamping strip block (6) is clamped in an inner groove of the denture base supporting part (7), so that the position of head imaging is adjusted;
the head formation of image screens device with adjustable includes: four clamping columns (2) arranged on a rotatable semi-cylindrical bottom support (1), two support bars (3) which are connected with each other in pairs of the clamping columns in the longitudinal section direction of the semi-cylindrical bottom support (1), and a head clamping part (4) which is connected between the two support bars (3) in the horizontal direction; the middle parts of the four clamping columns (2) are provided with clamping grooves which can be adjusted up and down, the two supporting bars (3) are connected in the clamping grooves in a sliding mode, the clamping grooves which can be adjusted front and back are formed in the two supporting bars (3), the head clamping part (4) is connected in the clamping grooves in a sliding mode, and the head clamping part (4) fixes the head at the optimal imaging position according to the size and the position of the head imaging area of a testee.
2. The optimized positioning device for head MRI as claimed in claim 1, wherein the MRI bed clamping device comprises two right-angle fixing blocks (9), each right-angle fixing block (9) has two slots on its right-angle surface, the nuclear magnetic resonance bed can be mounted by screwing into the slots in the horizontal direction, and the coil fixing device can be vertically displaced by screwing into the slots in the vertical direction and connected to the coil fixing device.
3. The optimized positioning device for magnetic resonance imaging of head as claimed in claim 1: the method is characterized in that the angle of the denture base is adjusted by matching with the rotation of the semi-cylindrical bottom base (1), so that a target brain area is closer to a scanning coil, and the optimal radio frequency excitation efficiency and the imaging signal-to-noise ratio of a head imaging area of a subject are obtained.
4. The optimized positioning device for magnetic resonance imaging of the head as claimed in claim 1, wherein the head imaging clamping device is adjusted in the front-back up-down direction according to the size and position of the head of the subject; the matching coil fixing device is adjusted in the front-back up-down direction, so that the head imaging area of the subject is located at the optimal position, namely, the surface coil and the surface coil array are fixed at the center of the nuclear magnetic resonance static magnetic field and are parallel to the trend of the magnetic field, the optimal excitation radio frequency pulse and the optimal nuclear magnetic resonance signal of the coil are obtained, and the high-quality nuclear magnetic resonance brain imaging result is obtained.
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CN113080930A (en) * 2021-05-10 2021-07-09 臧守红 Nuclear magnetic resonance diagnosis device for imaging department and use method
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CN115737145B (en) * 2022-11-24 2023-07-25 浙江大学 MR imaging positioning device for brain surgery

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