CN115353478B - Preparation method of indole compound - Google Patents

Preparation method of indole compound Download PDF

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CN115353478B
CN115353478B CN202210984796.3A CN202210984796A CN115353478B CN 115353478 B CN115353478 B CN 115353478B CN 202210984796 A CN202210984796 A CN 202210984796A CN 115353478 B CN115353478 B CN 115353478B
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compound
reaction
mixture
indole
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CN115353478A (en
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贾振华
张婷
吕永恒
张振国
罗德平
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Nanjing Tech University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

The invention discloses a preparation method of an indole compound, and belongs to the technical field of organic chemical synthesis. The invention provides a new synthetic route of indole compounds, introduces rare earth catalyst, has the advantages of novelty, high efficiency, high atom economy, mild reaction condition of 60 ℃, wide substrate application range and the like, does not need to add additional oxidant, only needs oxygen to participate, and can effectively reduce the generation of chemical waste. The operation is simple, only 7.5mol percent of rare earth catalyst and 15mol percent of DDQ additive are needed to be added, and compared with other reactions with stoichiometric additives, the cost is low, and the reaction efficiency is high. Compared with the traditional noble metal catalyst, the rare earth catalyst required in the preparation method has obvious advantages in terms of resource abundance, cost, preparation process, performance and the like. Not only can the production efficiency be improved, but also the resources and energy sources can be saved, the environmental pollution can be reduced, and the requirements of sustainable development are met.

Description

Preparation method of indole compound
Technical Field
The invention relates to the technical field of organic chemical synthesis, in particular to a preparation method for synthesizing an indole compound by using a rare earth catalyst.
Background
Indole is a compound in which pyrrole is connected in parallel with benzene, also known as benzopyrrole. Indole and its homologs and derivatives are widely found in nature, mainly in natural flower oil, coal tar; the essential oil (such as jasmine essential oil) also contains indole. Indole is an imine with weak basicity; the double bond of the heterocycle generally does not undergo an addition reaction; under the action of strong acid, the polymerization and the trimerization can be carried out; under special conditions, the aromatic electrophilic substitution reaction can be carried out. The application research of the method is not decayed, and new application fields are continuously developed.
Thus, their efficient synthetic routes have been a goal of a hot pursuit for the last decades. Representative Fischer indole synthesis and friedel-crafts quinoline synthesis routes used conventionally have been widely used in the fields of alkaloid synthesis and pharmaceutical synthesis. Up to now, under relatively severe conditions, stoichiometric oxidants or reagents (DDQ, iodate, peroxide and metal based oxidants) have traditionally been used for the dehydrogenation of saturated heterocycles to provide heterocyclic compounds. However, few catalytic systems have been reported for these reactions. Therefore, conventional methods with various catalyst bodies have appeared in recent years. From the perspective of aerobic dehydrogenation, various transition metal catalytic systems have been developed, such as Ir, co, fe, cu, ru and Mn. The Stahl group successfully used heterogeneous cobalt oxide catalysts for the aerobic dehydrogenation of N-heterocycles and ruthenium/quinone complexes for similar dehydrogenation-to indole in an efficient manner, these reactions using transition metal catalysis are not always suitable for indole synthesis and therefore the reaction window is relatively narrow. However, the use of stoichiometric oxidants or reagents is undesirable from an environmental and economic standpoint. Although many excellent catalytic systems have been explored under relatively mild conditions, most of these processes are based on the use of noble metals.
To date, few rare earth metal catalyzed indoline synthesis has been reported.
Disclosure of Invention
The invention aims to provide a preparation method for synthesizing indole compounds by rare earth catalysis, in the preparation method, required reaction raw materials (indoline or derivatives thereof) are cheap, easy to obtain, simple and easy to obtain, the range of substrates is wide, the reaction condition is mild, the temperature is 60 ℃, only a small amount of catalyst is used, the cost is low, and the reaction efficiency is high. The rare earth catalyst required in the preparation method has the advantages of being richer, cheaper, smaller in toxicity, high in atom economy and the like, does not need to add an additional oxidant, only needs oxygen to participate, and can effectively reduce the generation of chemical waste. The rare earth catalyzed preparation method for synthesizing indole compounds can improve production efficiency, save resources and energy, reduce environmental pollution and meet the requirement of sustainable development.
In order to solve the technical problems of the invention, the technical proposal is as follows: a process for the preparation of an indole compound, the process comprising the steps of:
in the above formulas (I) and (II), R 1 Is any one of hydrogen, methyl, methoxy, fluorine, chlorine, bromine, hydroxyl, methoxyacyl, amino, cyano, nitro and acetyl;
R 2 is any one of hydrogen, methyl, carboxyl, phenyl, methoxyacyl and ethoxyacyl;
R 3 is any one of hydrogen, methyl, acetyl, t-butoxycarbonyl, p-toluenesulfonyl, phenyl, benzyl and the like;
the preparation method comprises the following specific steps:
(1) Under the oxygen atmosphere, indoline or indoline derivative as shown in formula (I) and praseodymium trichloride heptahydrate PrCl as catalyst 3 ·7H 2 Sequentially adding O and an additive dichloro dicyanobenzoquinone DDQ into a reactor, and then adding an organic solvent 1,4-dioxane to obtain a mixture, wherein the indoline or indoline derivative, praseodymium trichloride heptahydrate (PrCl) 3 ·7H 2 O), dichlorodicyanobenzoquinone (DDQ) and organic solvent 1,4-dioxane in the molar volume ratio: 0.2mmol to 10mmol:0.015mmol to 0.75mmol:0.03mmol to 1.5mmol:1 mL-20 mL;
(2) And (3) reacting the mixture obtained in the step (1) for 1-16 hours under the heating condition to obtain the indole compound formula (II).
Preferably, in the step (1), indoline or indoline derivative, praseodymium trichloride heptahydrate catalyst and additive dichloro dicyanobenzoquinone are added, wherein the molar volume ratio of the solvent is as follows: 0.2mmol:0.015mmol:0.03mmol:1mL; in the step (2), the heating temperature is 60 ℃, and the reaction time is 12 hours.
Preferably, in step (1) the indoline or indoline derivative is any of indoline, 1-methylindoline, 1-acetylindoline, 1-t-butoxycarbonyl-indoline, 1-p-toluenesulfonyl-indoline, 1-phenylindoline, 1-benzylindoline, 2-methylindoline, 2-carboxyindoline, indoline-2-carboxylic acid ethyl ester, 2-phenylindoline, indoline-3-carboxylic acid methyl ester, 4-fluoroindoline, 4-chloroindoline, 5-methylindoline, 5-methoxyindoline, 5-fluoroindoline, 5-bromoindoline, 5-hydroxyindoline, 5-aminoindoline, 5-cyanoindoline, 5-acetylindoline, indoline-5-carboxylic acid methyl ester, 6-nitroindoline, 6-fluoroindoline, azaindoline.
Preferably, the indole compound of formula (II) is any one of the following indole compounds:
preferably, the synthesis method of the formula (II) is any one of the following indole compound synthesis methods.
Preferably, the preparation method of the indole compound,
specific preparation steps such asThe following steps: indoline 10mmol and praseodymium trichloride heptahydrate PrCl as catalyst 3 ·7H 2 0.75mmol of O and 1.5mmol of dichlorodicyanobenzoquinone as an additive were sequentially added to the reactor, then 1,4-dioxane organic solvent was added in place of oxygen protection, the reaction was heated and stirred at 60℃for 12 hours, TLC detection was performed, the mixture was diluted with 2mL of EA after the reaction, filtered with a silica gel column and washed with 10mL of EA, the filtrate was concentrated under reduced pressure, and the residue was purified by preparative thin layer chromatography or flash column chromatography.
The invention overcomes the defects of the prior art and provides a beta-carboline compound and a preparation method thereof, compared with the defects and the defects of the prior art, the invention has the following beneficial effects:
(1) The preparation method has the advantages that the needed reaction raw materials (indoline or derivatives thereof) are cheap and easy to obtain, the indole compounds are obtained by a one-step method, the problem that the existing indole derivative synthesis method is excessively complicated in reaction is solved, compared with the existing indole derivative synthesis method, the method has the mild condition and the temperature of 60 ℃, the operation is simple, only 7.5mol% of rare earth catalyst and 15mol% of DDQ additive are needed to be added, compared with other reactions with stoichiometric additives, the cost is low, the reaction efficiency is high, the atomic economy is high, and the generation of chemical waste can be effectively reduced.
(2) The catalyst required in the preparation method is a rare earth catalyst, the catalyst is economical and easy to obtain, a complex synthesis method is not needed, compared with the existing stoichiometric catalyst or heavy metal catalyst synthesis method, the catalytic amount of the rare earth catalyst is used for synthesizing indole compounds, and the method has the advantages of being richer, cheaper, smaller in toxicity, high in atom economy, free of adding additional oxidant, only needing oxygen to participate, capable of effectively reducing the generation of chemical waste materials and the like.
(3) In the preparation method, compared with the existing synthesis method, the substrate has wider range of synthesis, has good universality and can synthesize indole compounds in gram scale.
(4) In step (2) the heating temperature is 60 ℃ and the reaction time is 12 hours, and comparison of the gas atmosphere shows that oxygen is an essential reactant; in addition, the reaction temperature is reduced, which is unfavorable for the generation of target products. The solvent in the step (1) is 1,4-dioxane, other solvents replace 1,4-dioxane as reaction solvents, and the yield of target products is reduced to different degrees even the catalyst loses catalytic activity. The molar volume ratio of indoline or indoline derivative, rare earth catalyst, additive and solvent is as follows: for optimal reaction conditions, the catalyst dosage is reduced by 0.2mmol, 0.015mmol, and 1mL, and the yield of the target product starts to correspondingly decrease.
(5) Replacement of PrCl with other ion pair catalysts 3 ·7H 2 O is used as a catalyst for the reaction, so that the reaction effect is reduced to different degrees, and even the catalytic effect is lost.
Drawings
Nuclear magnetic hydrogen spectrum of compound 2 of figure 1 1 H NMR 400MHz,CDCl 3 )
FIG. 2 Nuclear magnetic carbon Spectrometry of Compound 2 13 C NMR 100MHz,CDCl 3 )
Detailed Description
The present invention will be further described in detail and fully illustrated in the following examples, which are set forth to facilitate an understanding of the present invention, but are not to be construed as limiting the scope of the present subject matter to the following examples, all techniques being accomplished based on the foregoing disclosure of the present invention.
General description:
abbreviations are used in the examples and have the following meanings:
me is methyl, et is a radical, boc is t-butoxycarbonyl, ph is phenyl, 1,4-Dioxane is 1,4-Dioxane, DCM is dichloromethane, PE is petroleum ether, and EA is ethyl acetate. TLC is thin layer chromatography, NMR is nuclear magnetic resonance, HRMS is high resolution mass spectrometry.
The solvent is purified by standard method and dried before use; all reagents are commercially available or synthesized according to the prior literature methods and purified prior to use.
Example 1:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is placed at 60 ℃ after sealing, and the mixture is heated and vigorously stirred for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 23mg of the objective compound in 98% yield.
1H-indole(1)
TLC:Rf＝0.43(silica gel,PE/EA,20:1),(23mg,98％yield),white solid. 1 H NMR(400MHz,CDCl 3 )δ8.13(s,1H),7.68(dq,J＝7.9,0.9Hz,1H),7.41(dq,J＝8.1,1.0Hz,1H),7.25–7.20(m,2H),7.15(ddd,J＝8.0,7.1,1.1Hz,1H),6.58(ddd,J＝3.1,2.0,1.0Hz,1H). 13 C NMR(101MHz,CDCl 3 )δ135.86,127.93,124.25,122.09,120.84,119.92,111.13,102.71.
Example 2:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is heated and vigorously stirred at 60 ℃ for 12 hours after sealing until complete reaction, TLC detection. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 24mg of the objective compound in 93% yield.
1-methyl-1H-indole(2)
TLC:Rf＝0.45(silica gel,PE/EA,50:1),(24mg,93％yield),colorless oil. 1 H NMR(400MHz,CDCl 3 )δ7.70(dt,J＝7.9,1.1Hz,1H),7.39(d,J＝8.2Hz,1H),7.35–7.24(m,1H),7.23–7.15(m,1H),7.10(d,J＝3.1Hz,1H),6.59–6.53(m,1H),3.83(s,3H). 13 C NMR(101MHz,CDCl 3 )δ136.83,128.94,128.62,121.62,121.01,119.41,109.34,101.02,32.93.
Example 3:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 33mg of the objective compound in 85% yield.
1-phenylindoline(3)
TLC:Rf＝0.46(silica gel,PE/EA,50:1),(33mg,85％yield),white solid. 1 H NMR(401MHz,CDCl 3 )δ7.72(ddt,J＝7.6,1.5,0.9Hz,1H),7.60(dp,J＝8.2,1.0Hz,1H),7.56–7.51(m,4H),7.42–7.35(m,2H),7.26(s,2H),6.71(dt,J＝3.2,0.9Hz,1H). 13 C NMR(101MHz,CDCl 3 )δ139.93,135.93,129.73,129.41,128.08,126.56,124.48,122.46,121.24,120.46,110.62,103.67.
Example 4:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 29mg of the objective compound in 70% yield.
1-phenyl-1H-indole(4)
TLC:Rf＝0.45(silica gel,PE/EA,50:1),(29mg,70％yield),yellow liquid. 1 H NMR(401MHz,CDCl 3 )δ7.69(dq,J＝7.7,1.1Hz,1H),7.35–7.27(m,4H),7.20(ddt,J＝8.2,7.0,1.3Hz,1H),7.14(ddt,J＝8.0,7.1,1.0Hz,4H),6.58(dd,J＝3.1,0.9Hz,1H),5.35(s,2H). 13 C NMR(101MHz,CDCl 3 )δ137.66,136.40,128.88,128.81,128.39,127.71,126.88,121.80,121.09,119.64,109.81,101.78,50.18.
Example 5:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaced oxygen 3 times, 1,4 dioxy was addedSix rings of 1mL, sealed, and heated at 60℃with vigorous stirring for 12 hours until complete reaction, TLC detection. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 12mg of the objective compound in 40% yield.
1-(1H-indol-1-yl)ethan-1-one(5)
TLC:Rf＝0.52(silica gel,PE/EA,10:1),(12mg,40％yield),Yellow solid. 1 H NMR(401MHz,CDCl 3 )δ8.45(d,J＝8.2Hz,1H),7.57(dt,J＝7.7,0.9Hz,1H),7.42(d,J＝3.8Hz,1H),7.36(ddd,J＝8.5,7.2,1.4Hz,1H),7.26(s,1H),6.65(dd,J＝3.8,0.8Hz,1H),2.64(s,3H). 13 C NMR(101MHz,CDCl 3 )δ168.81,135.64,130.51,125.34,125.24,123.78,120.95,116.65,109.29,24.11.
Example 6:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give the objective compound 20mg in 47% yield.
tert-butyl 1H-indole-1-carboxylate(6)
TLC:Rf＝0.43(silica gel,PE/EA,20:1),(20mg,47％yield),white solid. 1 H NMR(400MHz,CDCl 3 )δ8.13(s,1H),7.68(dq,J＝7.9,0.9Hz,1H),7.41(dq,J＝8.1,1.0Hz,1H),7.25–7.20(m,2H),7.15(ddd,J＝8.0,7.1,1.1Hz,1H),6.58(ddd,J＝3.1,2.0,1.0Hz,1H). 13 C NMR(101MHz,CDCl 3 )δ135.86,127.93,124.25,122.09,120.84,119.92,111.13,102.71.
Example 7:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 42mg of the objective compound in 78% yield.
1-tosyl-1H-indole(7)
TLC:Rf＝0.45(silica gel,PE/EA,50:1),(42mg,78％yield),colorless liquid. 1 H NMR(400MHz,CDCl 3 )δ7.99(dd,J＝8.3,0.9Hz,1H),7.80–7.73(m,2H),7.57(d,J＝3.7Hz,1H),7.53(dt,J＝7.8,1.1Hz,1H),7.31(dd,J＝15.6,1.3Hz,1H),7.25–7.14(m,3H),6.65(dd,J＝3.7,0.8Hz,1H),2.33(s,3H). 13 C NMR(101MHz,CDCl 3 )δ142.48,132.85,132.36,128.30,127.42,124.37,123.89,122.10,120.82,118.92,111.09,106.58,19.10.
Example 8:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken and a stirring magnet with proper size is arrangedSequentially and accurately weighing PrCl 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give the objective compound 20mg in 79% yield.
2-methyl-1H-indole(8)
TLC:Rf＝0.62(silica gel,PE/EA,20:1),(20mg,79％yield),white solid. 1 H NMR(401MHz,CDCl 3 )δ7.78(s,1H),7.58–7.52(m,1H),7.26(s,1H),7.19–7.06(m,2H),6.25(dq,J＝2.2,1.0Hz,1H),2.44(d,J＝0.9Hz,3H). 13 C NMR(101MHz,CDCl 3 )δ136.14,135.18,129.16,121.03,119.73,110.33,100.48,13.81.
Example 9:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 22mg of the objective compound in 58% yield.
2-phenyl-1H-indole(9)
TLC:Rf＝0.54(silica gel,PE/EA,10:1),(22mg,58％yield),off-white solid. 1 H NMR(401MHz,DMSO-d 6 )δ11.75–11.36(m,1H),7.91–7.82(m,2H),7.53(dd,J＝7.8,1.1Hz,1H),7.49–7.38(m,3H),7.35–7.26(m,1H),7.10(ddd,J＝8.1,7.0,1.2Hz,1H),7.00(ddd,J＝8.0,7.0,1.1Hz,1H),6.90(dd,J＝2.2,0.9Hz,1H). 13 C NMR(101MHz,DMSO-d 6 )δ138.14,137.66,132.75,129.44,129.16,127.93,125.51,122.11,120.58,119.91,112.38,99.20.
Example 10:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 36mg of the objective compound in 97% yield.
ethyl 1H-indole-2-carboxylate(10)
TLC:Rf＝0.52(silica gel,PE/EA,5:1),(36mg,97％yield),white solid. 1 H NMR(401MHz,CDCl 3 )δ9.09(s,1H),7.70(dq,J＝8.0,1.0Hz,1H),7.44(dq,J＝8.3,1.0Hz,1H),7.33(ddd,J＝8.3,7.0,1.1Hz,1H),7.26(s,1H),7.16(ddd,J＝8.0,6.9,1.0Hz,1H),4.43(q,J＝7.1Hz,2H),1.43(t,J＝7.1Hz,3H). 13 C NMR(101MHz,CDCl 3 )δ162.22,136.94,127.59,125.43,122.70,120.88,111.98,108.74,61.16,14.50.
Example 11:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 25mg of the objective compound in 70% yield.
methyl 1H-indole-3-carboxylate(11)
TLC:Rf＝0.54(silica gel,PE/EA,10:1),(25mg,70％yield),white solid. 1 H NMR(401MHz,DMSO-d 6 )δ11.92(s,1H),8.09(s,1H),8.03–7.97(m,1H),7.51–7.46(m,1H),7.23–7.14(m,2H),3.80(s,3H). 13 C NMR(101MHz,DMSO-d 6 )δ165.33,136.91,133.01,126.18,122.90,121.79,120.94,112.92,106.81,51.17.
Example 12:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 23mg of the objective compound in 85% yield.
4-fluoro-1H-indole(12)
TLC:Rf＝0.45(silica gel,PE/EA,20:1),(23mg,85％yield),off-white solid. 1 H NMR(401MHz,CDCl 3 )δ8.23(s,1H),7.22–7.16(m,2H),7.12(td,J＝7.9,5.0Hz,1H),6.81(ddd,J＝10.4,7.7,0.9Hz,1H),6.66(ddd,J＝3.1,2.1,0.9Hz,1H). 13 C NMR(101MHz,CDCl 3 )δ156.60(d,J＝246.6Hz),138.54(d,J＝11.3Hz),124.13,122.59(d,J＝7.7Hz),117.19(d,J＝22.7Hz),107.19(d,J＝3.8Hz),104.64(d,J＝19.0Hz),98.84. 19 F NMR(376MHz,CDCl 3 )δ-121.96.
Example 13:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give the objective compound 28mg in 92% yield.
4-chloro-1H-indole(13)
TLC:Rf＝0.46(silica gel,PE/EA,10:1),(28mg,92％yield),pale yellow solid. 1 H NMR(401MHz,CDCl 3 )δ8.26(s,1H),7.30(ddd,J＝6.8,2.0,0.9Hz,1H),7.25(dd,J＝5.4,2.2Hz,1H),7.16–7.08(m,2H),6.71–6.65(m,1H). 13 C NMR(101MHz,CDCl 3 )δ136.56,126.89,126.21,124.78,122.70,119.70,109.77,101.47.
Example 14:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 24mg of the objective compound in 93% yield.
5-methyl-1H-indole(14)
TLC:Rf＝0.46(silica gel,PE/EA,20:1),(24mg,93％yield),white solid. 1 H NMR(400MHz,CDCl 3 )δ7.95(s,1H),7.52–7.42(m,1H),7.26(s,1H),7.14(t,J＝2.9Hz,1H),7.05(dd,J＝8.2,1.7Hz,1H),6.49(ddd,J＝3.2,2.0,1.0Hz,1H),2.47(s,3H). 13 C NMR(101MHz,CDCl 3 )δ134.19,129.13,128.22,124.80,123.73,120.47,110.82,102.17,21.59.
Example 15:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 14mg of the objective compound in 50% yield.
5-methoxy-1H-indole(15)
TLC:Rf＝0.45(silica gel,PE/EA,20:1),(14mg,50％yield),white solid. 1 H NMR(401MHz,CDCl 3 )δ7.99(s,1H),7.47(dq,J＝1.7,0.8Hz,1H),7.30(dt,J＝8.3,0.9Hz,1H),7.17(dd,J＝3.2,2.4Hz,1H),7.06(dd,J＝8.3,1.6Hz,1H),6.51(ddd,J＝3.1,2.0,1.0Hz,1H),2.49(s,3H). 13 C NMR(101MHz,CDCl 3 )δ134.21,129.12,128.24,124.37,123.73,120.46,110.79,102.19,21.56.
Example 16:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 11mg of the objective compound in 40% yield.
1H-indol-5-ol(16)
TLC:Rf＝0.52(silica gel,PE/EA,10:1),(11mg,40％yield),white solid. 1 H NMR(401MHz,DMSO-d 6 )δ10.74(s,1H),8.69–8.56(m,1H),7.29–7.11(m,2H),6.90–6.82(m,1H),6.61(dt,J＝8.5,1.8Hz,1H),6.23(ddd,J＝3.0,2.0,0.9Hz,1H). 13 C NMR(101MHz,DMSO-d 6 )δ151.01,130.97,128.89,126.00,112.13,111.80,104.35,100.73.
Example 17:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 23mg of the objective compound in 87% yield.
1H-indol-5-amine(17)
TLC:Rf＝0.52(silica gel,PE/EA,20:1),(23mg,87％yield),brown oil. 1 H NMR(401MHz,DMSO-d 6 )δ10.57(s,1H),7.21–7.01(m,2H),6.69(q,J＝2.4Hz,1H),6.49(ddd,J＝8.5,4.0,1.9Hz,1H),6.13(p,J＝2.4Hz,1H),4.41(s,2H). 13 C NMR(101MHz,DMSO-d 6 )δ141.53,130.29,129.07,125.27,112.37,111.92,103.77,100.17.
Example 18:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 22mg of the objective compound in 80% yield.
5-fluoro-1H-indole(18)
TLC:Rf＝0.45(silica gel,PE/EA,20:1),(22mg,80％yield),off-white solid. 1 H NMR(401MHz,CDCl 3 )δ8.13(s,1H),7.32(d,J＝3.3Hz,1H),7.30(d,J＝5.1Hz,1H),7.26–7.23(m,1H),6.97(td,J＝9.1,2.5Hz,1H),6.54(t,J＝2.6Hz,1H). 13 C NMR(101MHz,CDCl 3 )δ152.19(d,J＝233.9Hz),126.52,122.40(d,J＝10.3Hz),120.17,105.83(d,J＝9.9Hz),104.65(d,J＝26.5Hz),99.67(d,J＝23.5Hz),97.02(d,J＝4.6Hz). 19 F NMR(376MHz,CDCl 3 )δ-124.81.
Example 19:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give 34mg of the objective compound in 86% yield.
5-bromo-1H-indole(19)
TLC:Rf＝0.44(silica gel,PE/EA,20:1),(34mg,86％yield),brown solid. 1 H NMR(400MHz,CDCl 3 )δ8.15(s,1H),7.84–7.70(m,1H),7.28(dd,J＝8.6,1.7Hz,1H),7.25(d,J＝8.6Hz,1H),7.20(t,J＝2.9Hz,1H),6.50(t,J＝2.2Hz,1H). 13 C NMR(101MHz,CDCl 3 )δ134.04,129.34,125.51,124.95,122.20,113.12,111.71,10240. Example 20:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give the objective compound 17mg in 50% yield.
methyl 1H-indole-5-carboxylate(20)
TLC:Rf＝0.54(silica gel,PE/EA,10:1),(17mg,50％yield),white solid. 1 H NMR(401MHz,CDCl 3 )δ8.53(s,1H),8.43(dd,J＝1.6,0.8Hz,1H),7.92(dd,J＝8.6,1.6Hz,1H),7.41(d,J＝8.6Hz,1H),7.27(dd,J＝5.6,3.0Hz,1H),6.65(t,J＝2.2Hz,1H),3.94(s,3H). 13 C NMR(101MHz,CDCl 3 )δ168.44,138.50,127.56,125.67,123.89,123.46,121.97,110.87,104.10,52.00.
Example 21:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). Concentrating the organic solvent under reduced pressure, and passing through siliconPurification by column chromatography gave 24mg of the title compound in 83% yield.
1H-indole-5-carbonitrile(21)
TLC:Rf＝0.48(silica gel,PE/EA,20:1),(24mg,83％yield),white solid. 1 H NMR(401MHz,CDCl 3 )δ8.75(s,1H),7.99(d,J＝1.4Hz,1H),7.53–7.29(m,3H),6.68–6.55(m,1H). 13 C NMR(101MHz,CDCl 3 )δ137.64,127.77,126.65,126.51,124.94,121.03,112.16,103.49,102.78.
Example 22:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give the objective compound 30mg in 93% yield.
1-(1H-indol-5-yl)ethan-1-one(22)
TLC:Rf＝0.42(silica gel,PE/EA,20:1),(30mg,93％yield),white solid. 1 H NMR(400MHz,CDCl 3 )δ8.78(s,1H),8.43–8.28(m,1H),7.88(dd,J＝8.6,1.7Hz,1H),7.42(dd,J＝8.6,0.9Hz,1H),7.26(s,1H),6.67(ddd,J＝3.1,2.0,1.0Hz,1H),2.68(d,J＝2.2Hz,3H). 13 C NMR(101MHz,CDCl 3 )δ198.93,138.65,129.96,127.51,125.97,123.25,122.33,111.18,104.32,26.78.
Example 23:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). The organic solvent was concentrated under reduced pressure and purified by silica gel column chromatography to give the objective compound (32 mg, yield 98%).
6-nitro-1H-indole(23)
TLC:Rf＝0.46(silica gel,PE/EA,5:1),(32mg,98％yield),yellow solid. 1 H NMR(400MHz,DMSO-d 6 )δ11.86(s,1H),8.35(d,J＝2.1Hz,1H),7.88(dd,J＝8.8,2.2Hz,1H),7.79(t,J＝2.8Hz,1H),7.72(d,J＝8.7Hz,1H),6.65(ddd,J＝2.9,1.9,0.9Hz,1H). 13 C NMR(101MHz,DMSO-d 6 )δ142.33,134.80,133.21,132.91,120.78,114.58,108.78,102.87.
Example 24:
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is sealed and then is heated and vigorously stirred at 60 ℃ for 12 hours until complete reaction, and TLC detection is carried out. After the reaction was completed, the mixture was diluted with EA (2 mL). Concentrating the organic solvent under reduced pressure, and passing through silica gel columnChromatography purification gave 21mg of the title compound in 76% yield.
6-fluoro-1H-indole(24)
TLC:Rf＝0.45(silica gel,PE/EA,20:1),(21mg,76％yield),off-white solid. 1 H NMR(400MHz,CDCl 3 )δ8.12(s,1H),7.56(dd,J＝8.7,5.3Hz,1H),7.19(s,1H),7.08(d,J＝9.6Hz,1H),6.98–6.81(m,1H),6.55(s,1H). 13 C NMR(101MHz,CDCl 3 )δ161.20,158.84,135.77(d,J＝12.5Hz),124.98–124.24(m),121.49(d,J＝10.1Hz),108.75(d,J＝24.5Hz),102.79,97.41(d,J＝26.1Hz). 19 F NMR(376MHz,CDCl 3 )δ-121.21.
Example 25:
gram-scale preparation method of compound 1: taking a 100mL round bottom reaction bottle, configuring a stirring magnet with proper size, and accurately weighing Pr (Cl) in sequence 3 ·7H 2 O (280 mg,0.75mmol,0.075 eq), DDQ (340 mg,1.5mmol,0.15 eq) and indoline (1.19 g,10mmol,1.0 eq). Then, the flask was sealed, evacuated and purged with O before injecting 20mL of anhydrous 1,4-dioxane via syringe 2 Backfilling for three times. The resulting pale yellow solution was heated in an oil bath at 60 ℃ and vigorously stirred for 12 hours. After completion of the reaction, the mixture was diluted with EA (20 mL), filtered through a short pad of silica gel, and washed with EA (50 mL). The filtrate was concentrated under reduced pressure, and the residue was purified by flash column chromatography using PE/EA (20:1) eluent to give the desired compound 2 (1.06 g, 90%) as a colorless oil.
Comparative example 1: comparison of ion to catalyst
/>
Replacement of PrCl with other ion pair catalysts 3 ·7H 2 O is used as a catalyst for the reaction, so that the reaction effect is reduced to different degrees, and even the catalytic effect is lost.
Comparative example 2: comparison of reaction solvents
Other solvents replace toluene as a reaction solvent, so that the yield of target products is reduced to different degrees and even the catalyst loses catalytic activity.
Comparative example 3: comparison of reaction temperatures
Other temperatures were used as reaction temperatures, and the yields of the target products were reduced to different extents.
Comparative example 4: comparison of catalyst amount
If other catalytic amounts are used for replacement, the yield of the target product is reduced to different degrees, and resources are saved and proper catalytic amounts are selected.
Comparative example 5: comparison of reaction time
Other times as reaction times, the yields of the target products all decreased to different extents.
Comparative example 6: comparison of reactive additives
/>
Other additives replace DDQ as a reaction additive, and the yield of target products is reduced to different degrees and even the catalyst loses catalytic activity.
Comparative example 7: quantitative screening of reaction additives
The other additive amounts are used as reaction additives, and the yield of the target product is reduced to different degrees.

Claims (1)

1. The preparation method of the indole compound is characterized by comprising any one of the following synthesis methods of the indole compound:
(1)
the preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is placed at 60 ℃ after sealing, and the mixture is heated and vigorously stirred for 12 hours until complete reaction, TLC detection is carried out; after completion of the reaction, the mixture was diluted with ethyl acetate EA 2 mL; concentrating the organic solvent under reduced pressure, purifying by silica gel column chromatography to obtain 23mg of the target compound with a yield of 98%; the indoline compound is as follows:the indole compounds are as follows: />
(2)
The preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is heated and vigorously stirred at 60 ℃ for 12 hours after sealing until complete reaction, TLC detection is carried out; after completion of the reaction, the mixture was diluted with EA 2 mL; concentrating the organic solvent under reduced pressure, purifying by silica gel column chromatography to obtain 24mg of the target compound with 93% yield; the indoline compound is as follows:the indole compounds are as follows: />
(3)
The preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is heated and vigorously stirred at 60 ℃ for 12 hours after sealing until complete reaction, TLC detection is carried out; after completion of the reaction, the mixture was diluted with EA 2 mL; concentrating the organic solvent under reduced pressure, purifying by silica gel column chromatography to obtain 33mg of the target compound, and yield85%; the indoline compound is as follows:the indole compounds are as follows: />
(4)
The preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is heated and vigorously stirred at 60 ℃ for 12 hours after sealing until complete reaction, TLC detection is carried out; after completion of the reaction, the mixture was released with EA 2 mL; concentrating the organic solvent under reduced pressure, purifying by silica gel column chromatography to obtain 36mg of the target compound with 97% yield; the indoline compound is as follows:the indole compounds are as follows: />
(5)
The preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is heated and vigorously stirred at 60 ℃ for 12 hours after sealing until complete reaction, TLC detection is carried out; after completion of the reaction, the mixture was diluted with EA 2 mL; decompressionConcentrating the organic solvent, purifying by silica gel column chromatography to obtain 23mg of the target compound with a yield of 85%; the indoline compound is as follows:the indole compounds are as follows: />
(6)
The preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is heated and vigorously stirred at 60 ℃ for 12 hours after sealing until complete reaction, TLC detection is carried out; after completion of the reaction, the mixture was released with EA 2 mL; concentrating the organic solvent under reduced pressure, purifying by silica gel column chromatography to obtain the target compound 28mg with a yield of 92%; the indoline compound is as follows:the indole compounds are as follows: />
(7)
The preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaced oxygen 3 times, and 1 was added1mL of 4 dioxane, sealing, heating and vigorously stirring at 60 ℃ for 12 hours until complete reaction, and detecting by TLC; after completion of the reaction, the mixture was diluted with EA 2 mL; concentrating the organic solvent under reduced pressure, purifying by silica gel column chromatography to obtain 24mg of the target compound with 93% yield; the indoline compound is as follows:the indole compounds are as follows: />
(8)
The preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is heated and vigorously stirred at 60 ℃ for 12 hours after sealing until complete reaction, TLC detection is carried out; after completion of the reaction, the mixture was diluted with EA 2 mL; concentrating the organic solvent under reduced pressure, purifying by silica gel column chromatography to obtain 23mg of the target compound, and obtaining 87% of the yield; the indoline compound is as follows:the indole compounds are as follows: />
(9)
The preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is heated and vigorously stirred at 60 ℃ for 12 hours after sealing until complete reaction, TLC detection is carried out; after completion of the reaction, the mixture was diluted with EA 2 mL; concentrating the organic solvent under reduced pressure, purifying by silica gel column chromatography to obtain 34mg of the target compound with 86% yield; the indoline compound is as follows:the indole compounds are as follows: />
(10)
The preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, a stirring magnet with proper size is configured, prCl is accurately weighed in sequence 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is heated and vigorously stirred at 60 ℃ for 12 hours after sealing until complete reaction, TLC detection is carried out; after completion of the reaction, the mixture was diluted with EA 2 mL; concentrating the organic solvent under reduced pressure, purifying by silica gel column chromatography to obtain the target compound 30mg with 93% yield; the indoline compound is as follows:the indole compounds are as follows: />
(11)
The preparation method of the indole compound comprises the following steps: 25mL Schlenk tube is taken, stirring magnetic seeds with proper size are configured, and the stirring magnetic seeds are accurately weighed in sequencePrCl 3 ·7H 2 O5.6 mg, DDQ 6.8mg, indoline compound 0.2mmol, the reaction system replaces oxygen 3 times, 1mL of 1,4 dioxane is added, the mixture is heated and vigorously stirred at 60 ℃ for 12 hours after sealing until complete reaction, TLC detection is carried out; after completion of the reaction, the mixture was diluted with EA 2 mL; concentrating the organic solvent under reduced pressure, purifying by silica gel column chromatography to obtain the target compound 32mg with a yield of 98%; the indoline compound is as follows:the indole compounds are as follows: />
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Title
5-氰基-6-硝基吲哚的合成;赵庆平等;化学试剂;第40卷(第6期);601-604 *
Using weak interactions to control C–H mono-nitration of indulines;Bose Anima等;Chem. Commun.;第53卷;11368 -11371 *

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