CN115320963B - Boxing cooling device and method for medicine box production - Google Patents
Boxing cooling device and method for medicine box production Download PDFInfo
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- CN115320963B CN115320963B CN202211210278.2A CN202211210278A CN115320963B CN 115320963 B CN115320963 B CN 115320963B CN 202211210278 A CN202211210278 A CN 202211210278A CN 115320963 B CN115320963 B CN 115320963B
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- air
- negative pressure
- cooling
- cooling device
- air extraction
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- 238000001816 cooling Methods 0.000 title claims abstract description 279
- 239000003814 drug Substances 0.000 title claims abstract description 198
- 238000000034 method Methods 0.000 title claims description 27
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- 238000000605 extraction Methods 0.000 claims abstract description 188
- 238000007789 sealing Methods 0.000 claims abstract description 120
- 238000004806 packaging method and process Methods 0.000 claims abstract description 94
- 238000009423 ventilation Methods 0.000 claims abstract description 64
- 229940079593 drug Drugs 0.000 claims abstract description 23
- 239000000112 cooling gas Substances 0.000 claims description 39
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical group O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 34
- 239000002775 capsule Substances 0.000 claims description 24
- 239000007789 gas Substances 0.000 claims description 24
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 17
- 239000001569 carbon dioxide Substances 0.000 claims description 17
- 238000012360 testing method Methods 0.000 claims description 13
- 238000005086 pumping Methods 0.000 claims description 7
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 229940127557 pharmaceutical product Drugs 0.000 claims description 2
- 238000012858 packaging process Methods 0.000 abstract description 6
- 230000036512 infertility Effects 0.000 abstract 1
- 238000012856 packing Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B63/00—Auxiliary devices, not otherwise provided for, for operating on articles or materials to be packaged
- B65B63/08—Auxiliary devices, not otherwise provided for, for operating on articles or materials to be packaged for heating or cooling articles or materials to facilitate packaging
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
- B65B31/02—Filling, closing, or filling and closing, containers or wrappers in chambers maintained under vacuum or superatmospheric pressure or containing a special atmosphere, e.g. of inert gas
- B65B31/025—Filling, closing, or filling and closing, containers or wrappers in chambers maintained under vacuum or superatmospheric pressure or containing a special atmosphere, e.g. of inert gas specially adapted for rigid or semi-rigid containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B43/00—Forming, feeding, opening or setting-up containers or receptacles in association with packaging
- B65B43/42—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Combustion & Propulsion (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Auxiliary Devices For And Details Of Packaging Control (AREA)
Abstract
The application discloses a boxing and cooling device for producing medicine boxes, which comprises a feeding device, a boxing device, a negative pressure ventilation device, a packaging device, a first air extraction and cooling device, a first plastic packaging device, a second air extraction and cooling device, a second plastic packaging device, a cooling section device and a sealing cover which are sequentially connected through a conveying device; the packaging device, the first air extraction cooling device, the first plastic packaging device, the second air extraction cooling device, the second plastic packaging device and the cooling section device are all positioned in the sealing cover; the negative pressure air interchanger is positioned outside the sealing cover and contacts the sealing cover; the sealing cover is filled with non-air component gas, the negative pressure ventilation device is used for replacing the gas in the medicine box with the non-air component gas, and the negative pressure ventilation device is used for reducing the temperature in the medicine box. The application realizes storage through multi-step cooling in the medicine packaging process, and is particularly suitable for medicines with high requirements on sterility and low temperature.
Description
Technical Field
The application relates to the field of medicines, in particular to the field of boxing and cooling.
Background
The existing cooling method after medicine boxing can be used for cooling through standing or adopting a cooling plate for heat transfer in the boxing process, but the cooling modes have low cooling efficiency generally, are uncontrollable and can easily form liquefied gas inside and outside the packaging box.
Disclosure of Invention
In order to solve the problems in the prior art, the application discloses a boxing and cooling device for producing medicine boxes, which comprises a feeding device, a boxing device, a negative pressure ventilation device, a packaging device, a first air extraction and cooling device, a first plastic packaging device, a second air extraction and cooling device, a second plastic packaging device, a cooling section device and a sealing cover which are sequentially connected through a conveying device; the feeding device is used for placing medicines and medicine boxes into the conveying device; the boxing device is used for placing the medicines on the conveying device into the medicine boxes;
the packaging device, the first air extraction cooling device, the first plastic packaging device, the second air extraction cooling device, the second plastic packaging device and the cooling section device are all positioned in the sealing cover; the negative pressure air interchanger is positioned outside the sealing cover and contacts the sealing cover; the sealing cover is filled with non-air component gas, the negative pressure ventilation device is used for replacing the gas in the medicine box with the non-air component gas, and the negative pressure ventilation device is used for reducing the temperature in the medicine box;
the packaging device is used for packaging the medicines in the medicine boxes; the first air extraction cooling device is used for reducing the internal and external temperatures of the medicine boxes subjected to the packaging device; the first plastic packaging device is used for partially plastic packaging the outer surface of the medicine box subjected to the first air extraction and cooling device; the second air extraction cooling device is used for reducing the internal and external temperatures of the medicine boxes subjected to the first plastic packaging device; the second plastic packaging device is used for completely plastic packaging the outer surface of the medicine box subjected to the second air extraction and cooling device; the cooling section device is used for reducing the peripheral temperature of the medicine box after the second plastic packaging device.
The medicine box cooling section device is used for cooling the medicine boxes, and comprises a cooling section device, a conveying device and a storage device, wherein the conveying device is used for conveying the medicine boxes subjected to the cooling section device to the storage device for storage;
the medicine comprises a capsule, and the capsule is subjected to negative pressure test in advance before the medicine is put into the medicine box, wherein the negative pressure test comprises the following steps of
Testing the pressure bearing of the capsule, namely marking the capsule as a P electrode, wherein the pressure bearing is not broken when the capsule is subjected to single negative pressure pumping;
and testing the pressure bearing of the capsule, namely P0, wherein the pressure bearing is not broken when the capsule continuously pumps negative pressure for 5 times, and the normal pressure is recovered after the negative pressure is pumped to the P pole each time in the process of pumping negative pressure for 5 times.
The negative pressure air interchanger comprises a negative pressure air interchanger base, a negative pressure air interchanger left cabin door, a negative pressure air interchanger left rotation center, a negative pressure air interchanger air inlet, a negative pressure air interchanger right cabin door, a negative pressure air interchanger right rotation center and a negative pressure air interchanger extraction opening;
the medicine box is positioned in the middle of the negative pressure ventilation device base; the negative pressure ventilation device left cabin door is connected with the negative pressure ventilation device through the negative pressure ventilation device left rotation center; the negative pressure ventilation device right cabin door is connected with the negative pressure ventilation device through the negative pressure ventilation device right rotation center; the right cabin door of the negative pressure air interchanger and the left cabin door of the negative pressure air interchanger rotate towards the outside of the negative pressure air interchanger so as to realize opening; the negative pressure air exchanging device air inlet and the negative pressure air exchanging device air extracting opening are all positioned at the top of the negative pressure air exchanging device.
The negative pressure ventilation device further comprises a first temperature sensor, and after the medicine box enters the negative pressure ventilation device, the distance between the first temperature sensor and the side part of the medicine box is smaller than 1cm and is not close to the medicine box;
after the medicine box enters the negative pressure air interchanger, the right cabin door of the negative pressure air interchanger and the left cabin door of the negative pressure air interchanger are both closed, the air inlet of the negative pressure air interchanger is closed, the air exhaust opening of the negative pressure air interchanger is opened to exhaust air to the negative pressure air interchanger until the air pressure in the negative pressure air interchanger is P1, and the P0 & ltP 1 & lt 1.5P0 is satisfied;
after the air pressure in the negative pressure air interchanger reaches P1, opening an air inlet of the negative pressure air interchanger, closing an air extraction opening of the negative pressure air interchanger, introducing cooling gas with the temperature of T1 through the air inlet of the negative pressure air interchanger, and stopping introducing the cooling gas into the negative pressure air interchanger through the air inlet of the negative pressure air interchanger when the temperature of T1 is detected by the first temperature sensor; in the process of introducing cooling gas into the negative pressure air interchanger through the negative pressure air interchanger air inlet, the left cabin door of the negative pressure air interchanger is kept in a closed state;
wherein the temperature in the storage device is T4, and 1.5T4 < T1 < 2T4 is satisfied.
The negative pressure air interchanger right cabin door is connected with the left side of the sealing cover, and the medicine box enters the sealing cover through the negative pressure air interchanger right cabin door; along the conveying direction of the medicine box, two ends of the sealing cover are respectively provided with a sealing cover air extracting opening and a sealing cover air inlet, the sealing cover air extracting opening is close to the right cabin door of the negative pressure air interchanger, and the sealing cover air inlet is close to the cooling section device; the sealing cover air inlet is positioned at the bottom of the sealing cover along the vertical direction, and the sealing cover air extraction opening is positioned at the top of the sealing cover or at the side part close to the top of the sealing cover; introducing the cooling gas into the sealed cover through the sealed cover air inlet, and extracting the cooling gas from the sealed cover through the sealed cover air extracting opening; the air inlet of the sealing cover and the air extraction opening of the sealing cover are all of a one-way air inlet structure; the temperature of the cooling gas at the air inlet of the sealing cover is the same as the temperature in the storage device.
The first air-extracting and cooling device comprises a first air-extracting and cooling device base, a first air-extracting and cooling device left cabin door, a first air-extracting and cooling device left rotation center, a first air-extracting and cooling device air inlet, a first air-extracting and cooling device right cabin door, a first air-extracting and cooling device right rotation center and a first air-extracting and cooling device air extracting opening; when the first air extraction cooling device works, the medicine box is positioned in the middle of the base of the first air extraction cooling device; the first air extraction cooling device left cabin door is connected with and rotates around the first air extraction cooling device left rotation center, the first air extraction cooling device right cabin door is connected with and rotates around the first air extraction cooling device right rotation center, the first air extraction cooling device air inlet is positioned at the top of the first air extraction cooling device and faces the medicine box, and the first air extraction cooling device air extraction opening is positioned at the side part of the first air extraction cooling device base; the air inlet of the first air suction cooling device and the air suction opening of the first air suction cooling device are all of a one-way air inlet structure;
after the medicine box enters the first air extraction and cooling device, the right cabin door of the first air extraction and cooling device and the first air extraction and cooling device are both closed, the air inlet of the first air extraction and cooling device is closed, the air extraction opening of the first air extraction and cooling device is opened to extract air from the first air extraction and cooling device until the air pressure in the first air extraction and cooling device is P2, and P1 & lt P2 is satisfied;
the first air extraction cooling device further comprises a second temperature sensor, and after the medicine box enters the first air extraction cooling device, the distance between the second temperature sensor and the side part of the medicine box is less than 1cm and is not close to the medicine box;
after the air pressure in the first air extraction cooling device reaches P2, opening an air inlet of the first air extraction cooling device, closing an air extraction opening of the first air extraction cooling device, introducing cooling gas with the temperature of T2 through the air inlet of the first air extraction cooling device, and stopping introducing cooling gas to the first air extraction cooling device through the air inlet of the first air extraction cooling device when the temperature of T2 is detected by the second temperature sensor; in the process of introducing cooling gas to the first air extraction cooling device through the air inlet of the first air extraction cooling device, the left cabin door of the first air extraction cooling device is kept in a closed state; t2 < T4 is satisfied.
After the medicine box passes through the first plastic sealing device, except the first side edge of the medicine box, other parts of the medicine box are all plastic sealed by a plastic sealing film, an upper sealing edge and a lower sealing edge are formed outside the first side edge by the plastic sealing film, the upper sealing edge and the lower sealing edge are plastic sealed, and an un-plastic sealing part is reserved between the upper sealing edge and the lower sealing edge;
when the medicine box passes through the second air extraction cooling device, the change process of air pressure and temperature in the second air extraction cooling device is the same as the change process of air pressure and temperature in the first air extraction cooling device.
The second plastic sealing device is used for plastic sealing the non-plastic sealing part between the upper edge sealing and the lower edge sealing.
The cooling section device comprises a cooling section device air inlet, and the cooling section device air inlet is opposite to the medicine box after the medicine box enters the cooling section device; the cooling section device does not comprise a left cabin door, a right cabin door and a rotation center; the temperature of cooling gas sprayed out of the air inlet of the cooling section is the same as that of the T2;
the negative pressure ventilation device air inlet, the first air extraction cooling device air inlet, the second air extraction cooling device air inlet and the cooling section device air inlet are connected with the same air source, and the cooling gas component in the air source is carbon dioxide.
The utility model discloses a boxing cooling method for producing medicine boxes, boxing cooling device for producing medicine boxes, the cooling method comprises the following steps:
step S1, feeding, namely placing the medicines and the medicine boxes into the conveying device through the feeding device;
s2, boxing, namely putting the medicines on the conveying device into the medicine boxes through the boxing device;
step S3, negative pressure ventilation is performed, the gas in the medicine box is replaced by carbon dioxide gas through the negative pressure ventilation device, and meanwhile, the temperature in the medicine box is reduced;
s4, packaging, namely packaging the medicines in the medicine boxes through the packaging device;
s5, first air extraction and cooling, wherein the temperature inside and outside the medicine box subjected to the packaging device is reduced through the first air extraction and cooling device;
s6, performing first plastic packaging, namely, performing plastic packaging on the outer surface part of the medicine box subjected to the first air extraction and cooling device through the first plastic packaging device;
s7, second air extraction and cooling, wherein the second air extraction and cooling device is used for reducing the internal and external temperatures of the medicine boxes subjected to the first plastic package device;
s8, performing second plastic packaging, namely completely plastic packaging the outer surface of the medicine box subjected to the second air extraction cooling device through the second plastic packaging device;
s9, a cooling section, wherein the temperature of the periphery of the medicine box subjected to the second plastic packaging device is reduced through the cooling section device;
step S10, a transportation section is used for transporting the medicine boxes subjected to the cooling section device to the storage device for storage;
and S11, a storage section is used for preserving the medicine boxes subjected to the transportation section at the temperature of T4 according to the medicine property requirements in the medicine boxes.
The method disclosed by the application has the following advantages:
firstly, the temperature of the inside and outside of the medicine box can reach the storage requirement by multi-step cooling and multi-step packaging matched with the packaging process, and the medicine property change caused by rapid cooling in the medicine packaging is reduced, and meanwhile, the generation of liquefied gas in the medicine packaging box is reduced;
secondly, ventilation, air extraction and cooling are adopted, so that cooling efficiency is improved;
and thirdly, carbon dioxide is used as cooling gas, and due to the characteristic of high density of the carbon dioxide, a specific suction port is adopted to reduce air residues in the equipment and the medicine boxes after the carbon dioxide is cooled, so that the cooling of aseptic medicines is facilitated.
Description of the drawings:
in order to more clearly illustrate the technical solution of the embodiments of the present application, the drawings that are needed in the description of the embodiments will be briefly described.
Fig. 1 is a schematic diagram of a method for cooling a box for producing a pharmaceutical pig according to the present application.
Fig. 2 is a schematic view of a box packing cooling device for producing the medicine box.
FIG. 3 is a schematic view of a negative pressure ventilation device according to the present application.
FIG. 4 is a schematic view of a first air extraction cooling device according to the present application.
Fig. 5 is a schematic diagram of the structure of the sealed edge of the pharmaceutical pig after the first packaging stage process of the present application.
FIG. 6 is a schematic view of a cooling section device of the present application.
1-a feeding device; 2-boxing device; 3-a negative pressure ventilation device; 4-packaging means; 5-a first air extraction cooling device; 6-a first plastic packaging device; 7-a second air extraction cooling device; 8-a second plastic packaging device; 9-a cooling section device; 101-sealing the outer frame body of the cover; 102-sealing the cover air inlet; 103, sealing the exhaust opening of the cover; 200-a medicine box; 201-upper edge sealing; 202-lower edge sealing; 31-a negative pressure ventilation device base; 32-a left cabin door of the negative pressure air interchanger; 33-left rotation center of negative pressure air interchanger; 34-negative pressure ventilator air inlet; 35-a right cabin door of the negative pressure air interchanger; 36-right rotation center of negative pressure air interchanger; 37-an extraction opening of the negative pressure air interchanger; 51-a first air extraction cooling device base; 52-a left cabin door of the first air extraction cooling device; 53-the left rotation center of the first air extraction cooling device; 54-a first air extraction cooling device air inlet; 55-a right cabin door of the first air extraction cooling device; 56-the right rotation center of the first air extraction cooling device; 57-an extraction opening of a first extraction cooling device; 91-cooling section device air inlet.
Detailed Description
The following will describe the technical scheme of the embodiment of the application clearly and completely; the application discloses a boxing and cooling device for producing medicine boxes,
as shown in fig. 2, the application discloses a boxing and cooling device for producing a medicine box (200), which comprises a feeding device (1), a boxing device (2), a negative pressure ventilation device (3), a packaging device (4), a first air extraction and cooling device (5), a first plastic packaging device (6), a second air extraction and cooling device (7), a second plastic packaging device (8), a cooling section device (9) and a sealing cover which are sequentially connected through a conveying device; the feeding device (1) is used for placing medicines and medicine boxes (200) into the conveying device; the boxing device (2) is used for placing the medicines on the conveying device into the medicine boxes (200);
the packaging device (4), the first air extraction cooling device (5), the first plastic packaging device (6), the second air extraction cooling device (7), the second plastic packaging device (8) and the cooling section device (9) are all positioned in the sealing cover; the negative pressure air exchanging device (3) is positioned outside the sealing cover and contacts the sealing cover; the sealing cover is filled with non-air component gas, the negative pressure ventilation device (3) is used for replacing the gas in the medicine box (200) with the non-air component gas, and the negative pressure ventilation device (3) is used for reducing the temperature in the medicine box (200);
the packaging means (4) is for packaging the pharmaceutical product within the pharmaceutical pig (200); the first air extraction cooling device (5) is used for reducing the internal and external temperatures of the medicine boxes (200) subjected to the packaging device (4); the first plastic packaging device (6) is used for plastic packaging of the outer surface part of the medicine box (200) subjected to the first air extraction and cooling device (5); the second air extraction cooling device (7) is used for reducing the internal and external temperatures of the medicine box (200) subjected to the first plastic sealing device (6); the second plastic packaging device (8) is used for completely plastic packaging the outer surface of the medicine box (200) subjected to the second air extraction and cooling device (7); the cooling section device (9) is used for reducing the peripheral temperature of the medicine box (200) subjected to the second plastic packaging device (8).
The medicine box cooling device further comprises a transportation device and a storage device, wherein the transportation device is used for transporting the medicine box (200) subjected to the cooling section device (9) into the storage device for storage;
the medicine comprises a capsule, and the capsule is subjected to a negative pressure test in advance before the medicine is put into the medicine box (200), wherein the negative pressure test comprises the following steps of
Testing the pressure bearing of the capsule, namely marking the capsule as a P electrode, wherein the pressure bearing is not broken when the capsule is subjected to single negative pressure pumping;
and testing the pressure bearing of the capsule, namely P0, wherein the pressure bearing is not broken when the capsule continuously pumps negative pressure for 5 times, and the normal pressure is recovered after the negative pressure is pumped to the P pole each time in the process of pumping negative pressure for 5 times. The negative pressure test can provide air pressure reference for the subsequent negative pressure ventilation and air extraction cooling, and prevent the air extraction process in the later stage from damaging the sealing property of the capsule.
The negative pressure air interchanger (3) comprises a negative pressure air interchanger base (31), a negative pressure air interchanger left cabin door (32), a negative pressure air interchanger left rotation center (33), a negative pressure air interchanger air inlet (34), a negative pressure air interchanger right cabin door (35), a negative pressure air interchanger right rotation center (36) and a negative pressure air interchanger air extraction opening (37);
as shown in fig. 3, the medicine box (200) is positioned in the middle of the negative pressure ventilation device base (31); the negative pressure ventilation device left cabin door (32) is connected with the negative pressure ventilation device (3) through the negative pressure ventilation device left rotation center (33); the negative pressure ventilation device right cabin door (35) is connected with the negative pressure ventilation device (3) through the negative pressure ventilation device right rotation center (36); the right cabin door (35) and the left cabin door (32) of the negative pressure air interchanger rotate towards the outside of the negative pressure air interchanger (3) to realize opening; the negative pressure air exchanging device air inlet (34) and the negative pressure air exchanging device air pumping hole (37) are all positioned at the top of the negative pressure air exchanging device (3).
The negative pressure ventilation device (3) further comprises a first temperature sensor (not shown in the figure), and after the medicine box (200) enters the negative pressure ventilation device (3), the distance between the first temperature sensor (not shown in the figure) and the side part of the medicine box (200) is less than 1cm and is not close to the medicine box (200);
after the medicine box (200) enters the negative pressure air interchanger (3), the right cabin door (35) of the negative pressure air interchanger and the left cabin door (32) of the negative pressure air interchanger are both closed, the air inlet (34) of the negative pressure air interchanger is closed, the air suction opening (37) of the negative pressure air interchanger is opened to suck air from the negative pressure air interchanger (3) until the air pressure in the negative pressure air interchanger (3) is P1, and P0 < P1 < 1.5P0 is satisfied; when P1 is smaller than P0, the capsule is at risk of rupture, and when P1 is larger than 1.5P0, excessive air remains in the negative pressure inflator.
After the air pressure in the negative pressure air interchanger (3) reaches P1, opening the negative pressure air interchanger air inlet (34), closing the negative pressure air interchanger air extraction opening (37), and introducing cooling gas with the temperature of T1 through the negative pressure air interchanger air inlet (34), and stopping introducing cooling gas into the negative pressure air interchanger (3) through the negative pressure air interchanger air inlet (34) when the first temperature sensor (not shown) detects the temperature of T1; during the process of introducing cooling gas into the negative pressure air interchanger (3) through the negative pressure air interchanger air inlet (34), the left cabin door (32) of the negative pressure air interchanger is kept in a closed state;
wherein the temperature in the storage device is T4, and 1.5T4 < T1 < 2T4 is satisfied. When T1 is smaller than 1.5T4, the temperature is reduced too quickly to destroy the drug property of the drug and generate liquefied gas inside and outside the drug box (200) or inside and outside the capsule, such as water vapor in the air is liquefied, and in addition, the temperature reduction step is further carried out, so that excessive temperature reduction is not required; when T1 is larger than 2T4, the cooling gas introduced into the negative pressure ventilation device (3) is too small, and at the moment, the air pressure in the negative pressure ventilation device (3) is too small, so that the right cabin door (35) of the negative pressure ventilation device cannot be opened.
The negative pressure ventilation device (3) is preferably carbon dioxide gas as cooling gas, and due to the high density of the carbon dioxide gas, the negative pressure ventilation device air inlet (34) is far away from the medicine box (200) and the first temperature sensor (not shown in the figure), so that most of the space inside the negative pressure ventilation device (3) can be filled before the cooling gas reaches the medicine box (200).
The negative pressure ventilation device right cabin door (35) is connected with the left side of the sealing cover, and the medicine box (200) enters the sealing cover through the negative pressure ventilation device right cabin door (35); along the conveying direction of the medicine box (200), the sealing cover comprises a sealing cover outer frame body (101), two ends of the sealing cover outer frame body (101) are respectively provided with a sealing cover air extraction opening (103) and a sealing cover air inlet (102), the sealing cover air extraction opening (103) is close to a right cabin door (35) of the negative pressure ventilation device, and the sealing cover air inlet (102) is close to the cooling section device (9); the sealing cover air inlet (102) is positioned at the bottom of the sealing cover along the vertical direction, and the sealing cover air extraction opening (103) is positioned at the top of the sealing cover or at the side part close to the top; introducing the cooling gas into the sealed cover through the sealed cover gas inlet (102), and extracting the cooling gas from the sealed cover through the sealed cover extraction opening (103); the sealing cover air inlet (102) and the sealing cover air extraction opening (103) are of a one-way air inlet structure; the cooling gas is at the same temperature at the sealed enclosure inlet (102) as the temperature within the storage device.
The sealing cover air inlet (102) and the sealing cover air extraction opening (103) are arranged in the structure, and because the density of carbon dioxide is high, the sealing cover air inlet (102) is arranged at the bottom of the right side of the sealing cover, and the sealing cover air extraction opening (103) is arranged at the upper part of the left side, so that the carbon dioxide can be conveniently used as cooling gas to fill the whole sealing cover.
As shown in fig. 4, the first air-extracting and cooling device (5) includes a first air-extracting and cooling device base (51), a first air-extracting and cooling device left cabin door (52), a first air-extracting and cooling device left rotation center (53), a first air-extracting and cooling device air inlet (54), a first air-extracting and cooling device right cabin door (55), a first air-extracting and cooling device right rotation center (56), and a first air-extracting and cooling device air extracting opening (57); when the first air extraction cooling device (5) works, the medicine box (200) is positioned in the middle of the first air extraction cooling device base (51); the first air extraction cooling device left cabin door (52) is connected with and rotates around the first air extraction cooling device left rotation center (53), the first air extraction is connected with and rotates around the first air extraction cooling device right rotation center (56), the first air extraction cooling device air inlet (54) is positioned at the top of the first air extraction cooling device (5) and is opposite to the medicine box (200), and the first air extraction cooling device air extraction opening (57) is positioned at the side part of the first air extraction cooling device base (51); the air inlet (54) of the first air suction cooling device and the air suction opening (57) of the first air suction cooling device are all of a one-way air inlet structure;
after the medicine box (200) enters the first air extraction and cooling device (5), the first air extraction and cooling device right cabin door (55) and the first air extraction and cooling device (5) are both closed, the first air extraction and cooling device air inlet (54) is closed, the first air extraction and cooling device air extraction opening (57) is opened to extract air from the first air extraction and cooling device (5) until the air pressure in the first air extraction and cooling device (5) is P2, and P1 & lt P2 is satisfied; because the sealed cowling space intussuseption is filled with low temperature carbon dioxide gas, first air extraction heat sink (5) play the further cooling effect of relative sealed cowling, need not to be less than negative pressure ventilation process can realize, simultaneously because medicine box (200) experience packaging process, the packaging process can produce the heat, and here first air extraction heat sink is convenient for in time discharges the heat that packaging process produced.
The first air extraction cooling device (5) further comprises a second temperature sensor (not shown in the figure), and after the medicine box (200) enters the first air extraction cooling device (5), the distance between the second temperature sensor (not shown in the figure) and the side part of the medicine box (200) is less than 1cm and is not close to the medicine box (200);
after the air pressure in the first air extraction and cooling device (5) reaches P2, opening an air inlet (54) of the first air extraction and cooling device, closing an air extraction opening (57) of the first air extraction and cooling device, introducing cooling gas with the temperature of T2 through the air inlet (54) of the first air extraction and cooling device, and stopping introducing cooling gas into the first air extraction and cooling device (5) through the air inlet (54) of the first air extraction and cooling device when the temperature of T2 is detected by the second temperature sensor (not shown in the figure); in the process of introducing cooling gas into the first air extraction and cooling device (5) through the air inlet (54) of the first air extraction and cooling device, the left cabin door (52) of the first air extraction and cooling device is kept in a closed state; t2 < T4 is satisfied.
As shown in fig. 5, after the medicine box (200) passes through the first plastic sealing device (6), except for the first side edge of the medicine box (200), other parts of the medicine box (200) are all plastic-sealed by plastic sealing films, an upper sealing edge (201) and a lower sealing edge (202) are formed outside the first side edge by the plastic sealing films, the upper sealing edge (201) and the lower sealing edge (202) are plastic-sealed, and an un-plastic sealing part is reserved between the upper sealing edge (201) and the lower sealing edge (202); this plastic envelope structure is convenient for second heat sink (7) of bleeding change the inside and outside gas of medicine box (200) and reduce heat, and the second plastic envelope process only needs plastic envelope non-plastic envelope portion simultaneously, has reduced the heat that the second plastic envelope process produced, because after the second plastic envelope, whole medicine box (200) can be plastic envelope, if the second plastic envelope process produces too much heat, then more difficult in time discharges through the cooling section.
When the medicine box (200) passes through the second air extraction cooling device (7), the change process of air pressure and temperature in the second air extraction cooling device (7) is the same as the change process of air pressure and temperature in the first air extraction cooling device (5).
The second plastic sealing device (8) is used for plastic sealing an un-plastic sealing part between the upper sealing edge (201) and the lower sealing edge (202).
As shown in fig. 6, the cooling section device (9) comprises a cooling section device (9) air inlet, and after the medicine box (200) enters the cooling section device (9), the cooling section device (9) air inlet is opposite to the medicine box (200); the cooling section device (9) does not comprise a left cabin door, a right cabin door and a rotation center; the temperature of cooling gas sprayed out of the air inlet of the cooling section is the same as that of the T2;
the negative pressure ventilation device air inlet (34), the first air extraction cooling device air inlet (54), the second air extraction cooling device (7) air inlet and the cooling section device (9) air inlet are connected with the same air source, and the cooling gas component in the air source is carbon dioxide.
As shown in fig. 1, a box packing cooling method for producing a medicine box (200), wherein the box packing cooling device for producing the medicine box (200) comprises the following steps:
step S1, feeding, namely placing the medicines and the medicine boxes (200) into the conveying device through the feeding device (1);
step S2, boxing, namely putting the medicines on the conveying device into the medicine boxes (200) through the boxing device (2);
step S3, negative pressure ventilation is performed, the gas in the medicine box (200) is replaced by carbon dioxide gas through the negative pressure ventilation device (3), and meanwhile, the temperature in the medicine box (200) is reduced;
step S4, packaging, wherein the medicine is packaged in the medicine box (200) through the packaging device (4);
s5, first air extraction and cooling, wherein the temperature inside and outside the medicine box (200) subjected to the packaging device (4) is reduced through the first air extraction and cooling device (5);
s6, performing first plastic packaging, namely performing plastic packaging on the outer surface part of the medicine box (200) subjected to the first air extraction and cooling device (5) through the first plastic packaging device (6);
s7, second air extraction and cooling, wherein the second air extraction and cooling device (7) is used for reducing the internal and external temperatures of the medicine boxes (200) subjected to the first plastic packaging device (6);
s8, performing second plastic packaging, namely performing complete plastic packaging on the outer surface of the medicine box (200) subjected to the second air extraction cooling device (7) through the second plastic packaging device (8);
step S9, a cooling section, wherein the temperature of the periphery of the medicine box (200) subjected to the second plastic packaging device (8) is reduced through the cooling section device (9);
step S10, a transportation section is used for transporting the medicine boxes (200) subjected to the cooling section device (9) to the storage device for storage;
and S11, a storage section is used for preserving the medicine boxes (200) subjected to the transportation section at the temperature of T4 according to the medicine property requirements in the medicine boxes (200).
The method disclosed by the application has the following advantages:
firstly, the temperature of the inside and outside of the medicine box can reach the storage requirement by multi-step cooling and multi-step packaging matched with the packaging process, and the medicine property change caused by rapid cooling in the medicine packaging is reduced, and meanwhile, the generation of liquefied gas in the medicine packaging box is reduced;
secondly, ventilation, air extraction and cooling are adopted, so that cooling efficiency is improved;
and thirdly, carbon dioxide is used as cooling gas, and due to the characteristic of high density of the carbon dioxide, a specific suction port is adopted to reduce air residues in the equipment and the medicine boxes after the carbon dioxide is cooled, so that the cooling of aseptic medicines is facilitated.
Claims (9)
1. The boxing and cooling device for producing the medicine boxes is characterized by comprising a feeding device, a boxing device, a negative pressure ventilation device, a packaging device, a first air extraction and cooling device, a first plastic packaging device, a second air extraction and cooling device, a second plastic packaging device, a cooling section device and a sealing cover which are sequentially connected through a conveying device; the feeding device is used for placing medicines and medicine boxes into the conveying device; the boxing device is used for placing the medicines on the conveying device into the medicine boxes;
the packaging device, the first air extraction cooling device, the first plastic packaging device, the second air extraction cooling device, the second plastic packaging device and the cooling section device are all positioned in the sealing cover; the negative pressure air interchanger is positioned outside the sealing cover and contacts the sealing cover; the sealing cover is filled with non-air component gas, the negative pressure ventilation device is used for replacing the gas in the medicine box with the non-air component gas, and the negative pressure ventilation device is used for reducing the temperature in the medicine box;
the packaging device is used for packaging the medicines in the medicine boxes; the first air extraction cooling device is used for reducing the internal and external temperatures of the medicine boxes subjected to the packaging device; the first plastic packaging device is used for partially plastic packaging the outer surface of the medicine box subjected to the first air extraction and cooling device; the second air extraction cooling device is used for reducing the internal and external temperatures of the medicine boxes subjected to the first plastic packaging device; the second plastic packaging device is used for completely plastic packaging the outer surface of the medicine box subjected to the second air extraction and cooling device; the cooling section device is used for reducing the peripheral temperature of the medicine box subjected to the second plastic packaging device;
the first air-extracting and cooling device comprises a first air-extracting and cooling device base, a first air-extracting and cooling device left cabin door, a first air-extracting and cooling device left rotation center, a first air-extracting and cooling device air inlet, a first air-extracting and cooling device right cabin door, a first air-extracting and cooling device right rotation center and a first air-extracting and cooling device air extracting opening; when the first air extraction cooling device works, the medicine box is positioned in the middle of the base of the first air extraction cooling device; the first air extraction cooling device left cabin door is connected with and rotates around the first air extraction cooling device left rotation center, the first air extraction cooling device right cabin door is connected with and rotates around the first air extraction cooling device right rotation center, the first air extraction cooling device air inlet is positioned at the top of the first air extraction cooling device and faces the medicine box, and the first air extraction cooling device air extraction opening is positioned at the side part of the first air extraction cooling device base; the air inlet of the first air suction cooling device and the air suction opening of the first air suction cooling device are all of a one-way air inlet structure;
after the medicine box enters the first air extraction and cooling device, the right cabin door of the first air extraction and cooling device and the first air extraction and cooling device are both closed, the air inlet of the first air extraction and cooling device is closed, the air extraction opening of the first air extraction and cooling device is opened to extract air from the first air extraction and cooling device until the air pressure in the first air extraction and cooling device is P2, and P1 & lt P2 is satisfied;
the first air extraction cooling device further comprises a second temperature sensor, and after the medicine box enters the first air extraction cooling device, the distance between the second temperature sensor and the side part of the medicine box is less than 1cm and is not close to the medicine box;
after the air pressure in the first air extraction cooling device reaches P2, opening an air inlet of the first air extraction cooling device, closing an air extraction opening of the first air extraction cooling device, introducing cooling gas with the temperature of T2 through the air inlet of the first air extraction cooling device, and stopping introducing cooling gas to the first air extraction cooling device through the air inlet of the first air extraction cooling device when the temperature of T2 is detected by the second temperature sensor; in the process of introducing cooling gas to the first air extraction cooling device through the air inlet of the first air extraction cooling device, the left cabin door of the first air extraction cooling device is kept in a closed state; t2 < T4 is satisfied.
2. The cartoning cooling device for pharmaceutical pig production of claim 1, further comprising a transport device and a storage device, wherein the transport device is used for transporting the pharmaceutical pig subjected to the cooling section device into the storage device for storage;
the medicine comprises a capsule, and the capsule is subjected to negative pressure test in advance before the medicine is put into the medicine box, wherein the negative pressure test comprises the following steps of
Testing the pressure bearing of the capsule, namely marking the capsule as a P electrode, wherein the pressure bearing is not broken when the capsule is subjected to single negative pressure pumping;
and testing the pressure bearing of the capsule, namely P0, wherein the pressure bearing is not broken when the capsule continuously pumps negative pressure for 5 times, and the normal pressure is recovered after the negative pressure is pumped to the P pole each time in the process of pumping negative pressure for 5 times.
3. The boxing and cooling device for producing medicine boxes according to claim 2, wherein the negative pressure air-changing device comprises a negative pressure air-changing device base, a negative pressure air-changing device left cabin door, a negative pressure air-changing device left rotation center, a negative pressure air-changing device air inlet, a negative pressure air-changing device right cabin door, a negative pressure air-changing device right rotation center and a negative pressure air-changing device air-extracting opening;
the medicine box is positioned in the middle of the negative pressure ventilation device base; the negative pressure ventilation device left cabin door is connected with the negative pressure ventilation device through the negative pressure ventilation device left rotation center; the negative pressure ventilation device right cabin door is connected with the negative pressure ventilation device through the negative pressure ventilation device right rotation center; the right cabin door of the negative pressure air interchanger and the left cabin door of the negative pressure air interchanger rotate towards the outside of the negative pressure air interchanger so as to realize opening; the negative pressure air exchanging device air inlet and the negative pressure air exchanging device air extracting opening are all positioned at the top of the negative pressure air exchanging device.
4. A pharmaceutical pig production cartoning heat sink according to claim 3, wherein the negative pressure ventilation device further comprises a first temperature sensor that is less than 1cm from the side of the pharmaceutical pig and is not close to the pharmaceutical pig after the pharmaceutical pig enters the negative pressure ventilation device;
after the medicine box enters the negative pressure air interchanger, the right cabin door of the negative pressure air interchanger and the left cabin door of the negative pressure air interchanger are both closed, the air inlet of the negative pressure air interchanger is closed, the air exhaust opening of the negative pressure air interchanger is opened to exhaust air to the negative pressure air interchanger until the air pressure in the negative pressure air interchanger is P1, and the P0 & ltP 1 & lt 1.5P0 is satisfied;
after the air pressure in the negative pressure air interchanger reaches P1, opening an air inlet of the negative pressure air interchanger, closing an air extraction opening of the negative pressure air interchanger, introducing cooling gas with the temperature of T1 through the air inlet of the negative pressure air interchanger, and stopping introducing the cooling gas into the negative pressure air interchanger through the air inlet of the negative pressure air interchanger when the temperature of T1 is detected by the first temperature sensor; in the process of introducing cooling gas into the negative pressure air interchanger through the negative pressure air interchanger air inlet, the left cabin door of the negative pressure air interchanger is kept in a closed state;
wherein the temperature in the storage device is T4, and 1.5T4 < T1 < 2T4 is satisfied.
5. The boxing and cooling device for producing medicine boxes according to claim 4, wherein the right cabin door of the negative pressure air interchanger is connected with the left side of the sealing cover, and the medicine boxes enter the sealing cover through the right cabin door of the negative pressure air interchanger; along the conveying direction of the medicine box, two ends of the sealing cover are respectively provided with a sealing cover air extracting opening and a sealing cover air inlet, the sealing cover air extracting opening is close to the right cabin door of the negative pressure air interchanger, and the sealing cover air inlet is close to the cooling section device; the sealing cover air inlet is positioned at the bottom of the sealing cover along the vertical direction, and the sealing cover air extraction opening is positioned at the top of the sealing cover or at the side part close to the top of the sealing cover; introducing the cooling gas into the sealed cover through the sealed cover air inlet, and extracting the cooling gas from the sealed cover through the sealed cover air extracting opening; the air inlet of the sealing cover and the air extraction opening of the sealing cover are all of a one-way air inlet structure; the temperature of the cooling gas at the air inlet of the sealing cover is the same as the temperature in the storage device.
6. The boxing and cooling device for producing medicine boxes according to claim 1, wherein after the medicine boxes pass through the first plastic sealing device, other parts of the medicine boxes are all plastic-sealed by plastic sealing films except for first side edges of the medicine boxes, the plastic sealing films form upper sealing edges and lower sealing edges outside the first side edges, the upper sealing edges and the lower sealing edges are plastic-sealed, and an un-plastic sealing part is reserved between the upper sealing edges and the lower sealing edges;
when the medicine box passes through the second air extraction cooling device, the change process of air pressure and temperature in the second air extraction cooling device is the same as the change process of air pressure and temperature in the first air extraction cooling device.
7. The cooling device for a pharmaceutical pig production box according to claim 6, wherein the second plastic sealing device is used for plastic sealing an un-plastic sealed portion between the upper edge seal and the lower edge seal.
8. A pharmaceutical pig manufacturing case cooling device according to claim 7, wherein the cooling section device comprises a cooling section device air inlet, after the medicine box enters the cooling section device, an air inlet of the cooling section device is opposite to the medicine box; the cooling section device does not comprise a left cabin door, a right cabin door and a rotation center; the temperature of cooling gas sprayed out of the air inlet of the cooling section is the same as that of the T2;
the negative pressure ventilation device air inlet, the first air extraction cooling device air inlet, the second air extraction cooling device air inlet and the cooling section device air inlet are connected with the same air source, and the cooling gas component in the air source is carbon dioxide.
9. A method for cooling a box for producing a pharmaceutical product, comprising the steps of:
step S1, feeding, namely placing the medicines and the medicine boxes into the conveying device through the feeding device;
s2, boxing, namely putting the medicines on the conveying device into the medicine boxes through the boxing device;
step S3, negative pressure ventilation is performed, the gas in the medicine box is replaced by carbon dioxide gas through the negative pressure ventilation device, and meanwhile, the temperature in the medicine box is reduced;
s4, packaging, namely packaging the medicines in the medicine boxes through the packaging device;
s5, first air extraction and cooling, wherein the temperature inside and outside the medicine box subjected to the packaging device is reduced through the first air extraction and cooling device;
s6, performing first plastic packaging, namely, performing plastic packaging on the outer surface part of the medicine box subjected to the first air extraction and cooling device through the first plastic packaging device;
s7, second air extraction and cooling, wherein the second air extraction and cooling device is used for reducing the internal and external temperatures of the medicine boxes subjected to the first plastic package device;
s8, performing second plastic packaging, namely completely plastic packaging the outer surface of the medicine box subjected to the second air extraction cooling device through the second plastic packaging device;
s9, a cooling section, wherein the temperature of the periphery of the medicine box subjected to the second plastic packaging device is reduced through the cooling section device;
step S10, a transportation section is used for transporting the medicine boxes subjected to the cooling section device to the storage device for storage;
and S11, a storage section is used for preserving the medicine boxes subjected to the transportation section at the temperature of T4 according to the medicine property requirements in the medicine boxes.
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| CN202211210278.2A CN115320963B (en) | 2022-09-30 | 2022-09-30 | Boxing cooling device and method for medicine box production |
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| CN202211210278.2A CN115320963B (en) | 2022-09-30 | 2022-09-30 | Boxing cooling device and method for medicine box production |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ITMI981511A1 (en) * | 1998-07-01 | 2000-01-01 | Ennevipi Technology Limited | PROCEDURE AND PLANT FOR THE PREPARATION OF PACKAGING OF FRESH PRE-COOKED FOODS |
| WO2005012103A1 (en) * | 2003-08-05 | 2005-02-10 | Kureha Corporation | Packaging device, measuring and packaging device, and method of manufacturing packaged article |
| JP2013220039A (en) * | 2012-04-13 | 2013-10-28 | Nisshin Seifun Group Inc | Method for producing food package |
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| CN111392138A (en) * | 2020-03-31 | 2020-07-10 | 连云港佑源医药设备制造有限公司 | Sterilization packaging method for plastic packaging food |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI981511A1 (en) * | 1998-07-01 | 2000-01-01 | Ennevipi Technology Limited | PROCEDURE AND PLANT FOR THE PREPARATION OF PACKAGING OF FRESH PRE-COOKED FOODS |
| WO2005012103A1 (en) * | 2003-08-05 | 2005-02-10 | Kureha Corporation | Packaging device, measuring and packaging device, and method of manufacturing packaged article |
| JP2013220039A (en) * | 2012-04-13 | 2013-10-28 | Nisshin Seifun Group Inc | Method for producing food package |
| CN207045834U (en) * | 2017-06-13 | 2018-02-27 | 中山市小榄镇丰兴包装机械厂 | Vacuum packing machine vacuum system |
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